Erin K. O'Shea - Publications

Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
signal transduction, transcriptional regulation

90 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates. Elife. 7. PMID 29745899 DOI: 10.7554/eLife.36620  0.72
2017 Puszynska AM, O'Shea EK. ppGpp Controls Global Gene Expression in Light and in Darkness in S. elongatus. Cell Reports. 21: 3155-3165. PMID 29241543 DOI: 10.1016/j.celrep.2017.11.067  0.6
2017 Piechura JR, Amarnath K, O'Shea EK. Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria. Elife. 6. PMID 29239721 DOI: 10.7554/eLife.32032  0.6
2017 He BZ, Zhou X, O'Shea EK. Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway. Elife. 6. PMID 28485712 DOI: 10.7554/eLife.25157  1
2017 Puszynska AM, O'Shea EK. Switching of metabolic programs in response to light availability is an essential function of the cyanobacterial circadian output pathway. Elife. 6. PMID 28430105 DOI: 10.7554/eLife.23210  0.6
2016 Zhou X, Blocker AW, Airoldi EM, O'Shea EK. A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution. Elife. 5. PMID 27623011 DOI: 10.7554/eLife.16970  1
2016 Hansen AS, O'Shea EK. Encoding four gene expression programs in the activation dynamics of a single transcription factor. Current Biology : Cb. 26: R269-71. PMID 27046808 DOI: 10.1016/j.cub.2016.02.058  1
2015 Hansen AS, O'Shea EK. cis Determinants of Promoter Threshold and Activation Timescale. Cell Reports. 12: 1226-33. PMID 26279577 DOI: 10.1016/j.celrep.2015.07.035  1
2014 Subramaniam AR, Zid BM, O'Shea EK. An integrated approach reveals regulatory controls on bacterial translation elongation. Cell. 159: 1200-11. PMID 25416955 DOI: 10.1016/j.cell.2014.10.043  1
2014 Zid BM, O'Shea EK. Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast. Nature. 514: 117-21. PMID 25119046 DOI: 10.1038/nature13578  1
2014 Mukherji S, O'Shea EK. Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance. Elife. 3: e02678. PMID 24916159 DOI: 10.7554/eLife.02678.001  1
2013 Subramaniam AR, Deloughery A, Bradshaw N, Chen Y, O'Shea E, Losick R, Chai Y. A serine sensor for multicellularity in a bacterium Elife. 2013. PMID 24347549 DOI: 10.7554/eLife.01501  1
2013 Markson JS, Piechura JR, Puszynska AM, O'Shea EK. Circadian control of global gene expression by the cyanobacterial master regulator RpaA. Cell. 155: 1396-408. PMID 24315105 DOI: 10.1016/j.cell.2013.11.005  1
2013 Hansen AS, O'Shea EK. Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression. Molecular Systems Biology. 9: 704. PMID 24189399 DOI: 10.1038/msb.2013.56  1
2013 Teng SW, Mukherji S, Moffitt JR, de Buyl S, O'Shea EK. Robust circadian oscillations in growing cyanobacteria require transcriptional feedback. Science (New York, N.Y.). 340: 737-40. PMID 23661759 DOI: 10.1126/science.1230996  1
2013 Gutu A, O'Shea EK. Two antagonistic clock-regulated histidine kinases time the activation of circadian gene expression. Molecular Cell. 50: 288-94. PMID 23541768 DOI: 10.1016/j.molcel.2013.02.022  1
2013 Hao N, Budnik BA, Gunawardena J, O'Shea EK. Tunable signal processing through modular control of transcription factor translocation. Science (New York, N.Y.). 339: 460-4. PMID 23349292 DOI: 10.1126/science.1227299  1
2013 Vijayan V, O'Shea EK. Sequence determinants of circadian gene expression phase in cyanobacteria. Journal of Bacteriology. 195: 665-71. PMID 23204469 DOI: 10.1128/JB.02012-12  1
2012 Carter-O'Connell I, Peel MT, Wykoff DD, O'Shea EK. Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe. Bmc Genomics. 13: 697. PMID 23231582 DOI: 10.1186/1471-2164-13-697  1
2012 Cook KE, O'Shea EK. Hog1 controls global reallocation of RNA Pol II upon osmotic shock in Saccharomyces cerevisiae. G3 (Bethesda, Md.). 2: 1129-36. PMID 22973550 DOI: 10.1534/g3.112.003251  1
2012 Jain IH, Vijayan V, O'Shea EK. Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. 109: 13638-43. PMID 22869746 DOI: 10.1073/pnas.1211144109  1
2012 Grimes CL, Ariyananda Lde Z, Melnyk JE, O'Shea EK. The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment. Journal of the American Chemical Society. 134: 13535-7. PMID 22857257 DOI: 10.1021/ja303883c  1
2012 Hao N, O'Shea EK. Signal-dependent dynamics of transcription factor translocation controls gene expression. Nature Structural & Molecular Biology. 19: 31-9. PMID 22179789 DOI: 10.1038/nsmb.2192  1
2011 Zhou X, O'Shea EK. Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4. Molecular Cell. 42: 826-36. PMID 21700227 DOI: 10.1016/j.molcel.2011.05.025  1
2011 Vijayan V, Jain IH, O'Shea EK. A high resolution map of a cyanobacterial transcriptome. Genome Biology. 12: R47. PMID 21612627 DOI: 10.1186/gb-2011-12-5-r47  1
2010 Grimes CL, Podolsky DK, O'Shea EK. Synthesis of biologically active biotinylated muramyl dipeptides. Bioorganic & Medicinal Chemistry Letters. 20: 6061-3. PMID 20822907 DOI: 10.1016/j.bmcl.2010.08.056  1
2009 Vijayan V, Zuzow R, O'Shea EK. Oscillations in supercoiling drive circadian gene expression in cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. 106: 22564-8. PMID 20018699 DOI: 10.1073/pnas.0912673106  1
2009 Markson JS, O'Shea EK. The molecular clockwork of a protein-based circadian oscillator. Febs Letters. 583: 3938-47. PMID 19913541 DOI: 10.1016/j.febslet.2009.11.021  1
2009 Kim HD, Shay T, O'Shea EK, Regev A. Transcriptional regulatory circuits: predicting numbers from alphabets. Science (New York, N.Y.). 325: 429-32. PMID 19628860 DOI: 10.1126/science.1171347  1
2008 Capaldi AP, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, O'Shea EK. Structure and function of a transcriptional network activated by the MAPK Hog1. Nature Genetics. 40: 1300-6. PMID 18931682 DOI: 10.1038/ng.235  1
2008 Kim HD, O'Shea EK. A quantitative model of transcription factor-activated gene expression. Nature Structural & Molecular Biology. 15: 1192-8. PMID 18849996 DOI: 10.1038/nsmb.1500  1
2008 Lam FH, Steger DJ, O'Shea EK. Chromatin decouples promoter threshold from dynamic range. Nature. 453: 246-50. PMID 18418379 DOI: 10.1038/nature06867  1
2008 Lee YS, Huang K, Quiocho FA, O'Shea EK. Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate. Nature Chemical Biology. 4: 25-32. PMID 18059263 DOI: 10.1038/nchembio.2007.52  1
2007 Huang K, Ferrin-O'Connell I, Zhang W, Leonard GA, O'Shea EK, Quiocho FA. Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway. Molecular Cell. 28: 614-23. PMID 18042456 DOI: 10.1016/j.molcel.2007.09.013  0.68
2007 Rust MJ, Markson JS, Lane WS, Fisher DS, O'Shea EK. Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (New York, N.Y.). 318: 809-12. PMID 17916691 DOI: 10.1126/science.1148596  0.4
2007 Wykoff DD, Rizvi AH, Raser JM, Margolin B, O'Shea EK. Positive feedback regulates switching of phosphate transporters in S. cerevisiae. Molecular Cell. 27: 1005-13. PMID 17889672 DOI: 10.1016/j.molcel.2007.07.022  0.44
2007 Maheshri N, O'Shea EK. Living with noisy genes: how cells function reliably with inherent variability in gene expression. Annual Review of Biophysics and Biomolecular Structure. 36: 413-34. PMID 17477840 DOI: 10.1146/annurev.biophys.36.040306.132705  1
2007 Lee YS, Mulugu S, York JD, O'Shea EK. Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. Science (New York, N.Y.). 316: 109-12. PMID 17412959 DOI: 10.1126/science.1139080  1
2006 Belle A, Tanay A, Bitincka L, Shamir R, O'Shea EK. Quantification of protein half-lives in the budding yeast proteome. Proceedings of the National Academy of Sciences of the United States of America. 103: 13004-9. PMID 16916930 DOI: 10.1073/pnas.0605420103  1
2006 Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, Pilpel Y, Barkai N. Noise in protein expression scales with natural protein abundance. Nature Genetics. 38: 636-43. PMID 16715097 DOI: 10.1038/ng1807  1
2006 Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, Punna T, Peregrín-Alvarez JM, Shales M, Zhang X, Davey M, et al. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 440: 637-43. PMID 16554755 DOI: 10.1038/nature04670  1
2005 Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK. Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains. Comparative and Functional Genomics. 6: 2-16. PMID 18629296 DOI: 10.1002/cfg.449  1
2005 Dephoure N, Howson RW, Blethrow JD, Shokat KM, O'Shea EK. Combining chemical genetics and proteomics to identify protein kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 102: 17940-5. PMID 16330754 DOI: 10.1073/pnas.0509080102  0.4
2005 Raser JM, O'Shea EK. Noise in gene expression: origins, consequences, and control. Science (New York, N.Y.). 309: 2010-3. PMID 16179466 DOI: 10.1126/science.1105891  1
2005 Huang S, O'Shea EK. A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation. Genetics. 169: 1859-71. PMID 15695358 DOI: 10.1534/genetics.104.038695  1
2005 Wykoff DD, O'Shea EK. Identification of sumoylated proteins by systematic immunoprecipitation of the budding yeast proteome. Molecular & Cellular Proteomics : McP. 4: 73-83. PMID 15596868 DOI: 10.1074/mcp.M400166-MCP200  1
2004 Weissman JS, O'Shea EK. 2004 Irving Sigal Young Investigator Award. Protein Science : a Publication of the Protein Society. 13: 3333-5. PMID 15557272 DOI: 10.1110/ps.041134604  1
2004 Marion RM, Regev A, Segal E, Barash Y, Koller D, Friedman N, O'Shea EK. Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proceedings of the National Academy of Sciences of the United States of America. 101: 14315-22. PMID 15353587 DOI: 10.1073/pnas.0405353101  1
2004 Raser JM, O'Shea EK. Control of stochasticity in eukaryotic gene expression. Science (New York, N.Y.). 304: 1811-4. PMID 15166317 DOI: 10.1126/science.1098641  1
2004 Steger DJ, O'Shea EK. Genetic analysis of chromatin remodeling using budding yeast as a model. Methods in Enzymology. 377: 55-60. PMID 14979017 DOI: 10.1016/S0076-6879(03)77002-5  1
2004 Byrne M, Miller N, Springer M, O'Shea EK. A distal, high-affinity binding site on the cyclin-CDK substrate Pho4 is important for its phosphorylation and regulation. Journal of Molecular Biology. 335: 57-70. PMID 14659740 DOI: 10.1016/j.jmb.2003.10.035  1
2003 Springer M, Wykoff DD, Miller N, O'Shea EK. Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. Plos Biology. 1: E28. PMID 14624238 DOI: 10.1371/journal.pbio.0000028  1
2003 Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS. Global analysis of protein expression in yeast. Nature. 425: 737-41. PMID 14562106 DOI: 10.1038/nature02046  1
2003 Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK. Global analysis of protein localization in budding yeast. Nature. 425: 686-91. PMID 14562095 DOI: 10.1038/nature02026  0.92
2003 Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK. Regulation of chromatin remodeling by inositol polyphosphates. Science (New York, N.Y.). 299: 114-6. PMID 12434012 DOI: 10.1126/science.1078062  1
2002 O'Rourke SM, Herskowitz I, O'Shea EK. Yeast go the whole HOG for the hyperosmotic response. Trends in Genetics : Tig. 18: 405-12. PMID 12142009 DOI: 10.1016/S0168-9525(02)02723-3  1
2002 Herskowitz I, O'Shea E. The 2001 Thomas Hunt Morgan Medal. Yasuji Oshima. Genetics. 160: 367-8. PMID 11894818  1
2002 Carroll AS, O'Shea EK. Pho85 and signaling environmental conditions. Trends in Biochemical Sciences. 27: 87-93. PMID 11852246 DOI: 10.1016/S0968-0004(01)02040-0  1
2002 Bourne HR, O'Shea EK. Cell regulation Current Opinion in Cell Biology. 14: 137-139. DOI: 10.1016/S0955-0674(02)00320-4  1
2001 Wykoff DD, O'Shea EK. Phosphate transport and sensing in Saccharomyces cerevisiae. Genetics. 159: 1491-9. PMID 11779791  1
2001 Komeili A, O'Shea EK. New perspectives on nuclear transport. Annual Review of Genetics. 35: 341-64. PMID 11700287 DOI: 10.1146/annurev.genet.35.102401.090720  1
2001 Carroll AS, Bishop AC, DeRisi JL, Shokat KM, O'Shea EK. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proceedings of the National Academy of Sciences of the United States of America. 98: 12578-83. PMID 11675494 DOI: 10.1073/pnas.211195798  0.52
2001 Huang S, Jeffery DA, Anthony MD, O'Shea EK. Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain. Molecular and Cellular Biology. 21: 6695-705. PMID 11533256 DOI: 10.1128/MCB.21.19.6695-6705.2001  1
2001 Jeffery DA, Springer M, King DS, O'Shea EK. Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference. Journal of Molecular Biology. 306: 997-1010. PMID 11237614 DOI: 10.1006/jmbi.2000.4417  1
2001 Lenburg ME, O'Shea EK. Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics. 157: 39-51. PMID 11139490  1
2000 Komeili A, Wedaman KP, O'Shea EK, Powers T. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. The Journal of Cell Biology. 151: 863-78. PMID 11076970 DOI: 10.1083/jcb.151.4.863  1
2000 Komeili A, O'Shea EK. Nuclear transport and transcription. Current Opinion in Cell Biology. 12: 355-60. PMID 10801461 DOI: 10.1016/S0955-0674(00)00100-9  1
2000 O'Shea EK, Herskowitz I. The ins and outs of cell-polarity decisions. Nature Cell Biology. 2: E39-41. PMID 10707093 DOI: 10.1038/35004065  1
2000 Lau WT, Howson RW, Malkus P, Schekman R, O'Shea EK. Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p. Proceedings of the National Academy of Sciences of the United States of America. 97: 1107-12. PMID 10655492 DOI: 10.1073/pnas.97.3.1107  0.56
1999 Kaffman A, O'Shea EK. Regulation of nuclear localization: a key to a door. Annual Review of Cell and Developmental Biology. 15: 291-339. PMID 10611964 DOI: 10.1146/annurev.cellbio.15.1.291  1
1999 Komeili A, O'Shea EK. Roles of phosphorylation sites in regulating activity of the transcription factor Pho4. Science (New York, N.Y.). 284: 977-80. PMID 10320381 DOI: 10.1126/science.284.5416.977  1
1999 Haswell ES, O'Shea EK. An in vitro system recapitulates chromatin remodeling at the PHO5 promoter. Molecular and Cellular Biology. 19: 2817-27. PMID 10082547  1
1998 Haswell ES, O'Shea EK. Specificity of ATP-dependent chromatin remodeling at the yeast PHO5 promoter. Cold Spring Harbor Symposia On Quantitative Biology. 63: 563-7. PMID 10384321  1
1998 Kaffman A, Rank NM, O'Neill EM, Huang LS, O'Shea EK. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature. 396: 482-6. PMID 9853758 DOI: 10.1038/24898  1
1998 Lau WW, Schneider KR, O'Shea EK. A genetic study of signaling processes for repression of PHO5 transcription in Saccharomyces cerevisiae. Genetics. 150: 1349-59. PMID 9832515  0.56
1998 Kaffman A, Rank NM, O'Shea EK. Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Genes & Development. 12: 2673-83. PMID 9732266  1
1996 Lenburg ME, O'Shea EK. Signaling phosphate starvation. Trends in Biochemical Sciences. 21: 383-7. PMID 8918192 DOI: 10.1016/0968-0004(96)10048-7  1
1996 O'Neill EM, Kaffman A, Jolly ER, O'Shea EK. Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science (New York, N.Y.). 271: 209-12. PMID 8539622  1
1995 O'Neill EM, O'Shea EK. Transcriptional regulation. Cyclins in initiation. Nature. 374: 121-2. PMID 7877679 DOI: 10.1038/374121a0  1
1994 Kaffman A, Herskowitz I, Tjian R, O'Shea EK. Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science (New York, N.Y.). 263: 1153-6. PMID 8108735  1
1994 Schneider KR, Smith RL, O'Shea EK. Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the CDK inhibitor PHO81. Science (New York, N.Y.). 266: 122-6. PMID 7939631  1
1993 O'Shea EK, Lumb KJ, Kim PS. Peptide 'Velcro': design of a heterodimeric coiled coil. Current Biology : Cb. 3: 658-67. PMID 15335856 DOI: 10.1016/0960-9822(93)90063-T  1
1992 O'Shea EK, Rutkowski R, Kim PS. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell. 68: 699-708. PMID 1739975  1
1991 Rasmussen R, Benvegnu D, O'Shea EK, Kim PS, Alber T. X-ray scattering indicates that the leucine zipper is a coiled coil. Proceedings of the National Academy of Sciences of the United States of America. 88: 561-4. PMID 1988953  1
1991 O'Shea EK, Klemm JD, Kim PS, Alber T. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science (New York, N.Y.). 254: 539-44. PMID 1948029  1
1990 Oas TG, McIntosh LP, O'Shea EK, Dahlquist FW, Kim PS. Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy. Biochemistry. 29: 2891-4. PMID 2337572  1
1990 Hu JC, O'Shea EK, Kim PS, Sauer RT. Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions. Science (New York, N.Y.). 250: 1400-3. PMID 2147779  1
1989 O'Shea EK, Rutkowski R, Kim PS. Evidence that the leucine zipper is a coiled coil. Science (New York, N.Y.). 243: 538-42. PMID 2911757  1
1989 Weiss MA, Nguyen DT, Khait I, Inouye K, Frank BH, Beckage M, O'Shea E, Shoelson SE, Karplus M, Neuringer LJ. Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics. Biochemistry. 28: 9855-73. PMID 2692717  1
1989 O'Shea EK, Rutkowski R, Stafford WF, Kim PS. Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science (New York, N.Y.). 245: 646-8. PMID 2503872  1
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