Chrystal M. Paulos, Ph.D. - Publications

2004 Purdue University, West Lafayette, IN, United States 
ligand-targeted imaging and therapeutic agents for the diagnosis and treatment of important human diseases

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Horvat NK, Karpovsky I, Phillips M, Wyatt MM, Hall MA, Herting CJ, Hammons J, Mahdi Z, Moffitt RA, Paulos CM, Lesinski GB. Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy. Journal For Immunotherapy of Cancer. 12. PMID 38191243 DOI: 10.1136/jitc-2023-008086  0.337
2023 Rangel Rivera GO, Dwyer CJ, Knochelmann HM, Smith AS, Aksoy BA, Cole AC, Wyatt MM, Kumaresan S, Thaxton JE, Lesinski GB, Paulos CM. Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity. Cancer Research. PMID 37801615 DOI: 10.1158/0008-5472.CAN-23-0801  0.383
2023 Bennion KB, Tariq M, Wyatt MM, Duneton C, Baecher KM, Paulos CM, Kudchadkar RR, Lowe MC, Ford ML. FcγRIIB expressed on CD8 T cells limits responsiveness to PD-1 checkpoint inhibition in cancer. Science Translational Medicine. 15: eadd1868. PMID 37611081 DOI: 10.1126/scitranslmed.add1868  0.392
2023 Zhang H, Passang T, Ravindranathan S, Bommireddy R, Jajja MR, Yang L, Selvaraj P, Paulos CM, Waller EK. The magic of small-molecule drugs during expansion in adoptive cell therapy. Frontiers in Immunology. 14: 1154566. PMID 37153607 DOI: 10.3389/fimmu.2023.1154566  0.359
2023 Wyatt MM, Huff LW, Nelson MH, Neal LR, Medvec AR, Rangel Rivera GO, Smith AS, Rivera Reyes AM, Knochelmann HM, Riley JL, Lesinski GB, Paulos CM. Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 37081789 DOI: 10.1016/j.ymthe.2023.04.010  0.341
2023 Rangel Rivera GO, Dwyer CJ, Knochelmann HM, Smith AS, Aksoy A, Cole AC, Wyatt MM, Thaxton JE, Lesinski GB, Paulos CM. The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner. Biorxiv : the Preprint Server For Biology. PMID 36945574 DOI: 10.1101/2023.03.08.531589  0.366
2023 Ware MB, Phillips M, McQuinn C, Zaidi MY, Knochelmann HM, Greene E, Robinson BS, Herting CJ, Mace TA, Chen Z, Zhang C, Farren MR, Ruggieri AN, Bowers JS, Shakya R, ... ... Paulos CM, et al. Dual IL-6 and CTLA-4 blockade regresses pancreatic tumors in a T cell and CXCR3-dependent manner. Jci Insight. PMID 36881480 DOI: 10.1172/jci.insight.155006  0.396
2023 Camargo CP, Muhuri AK, Alapan Y, Sestito LF, Khosla M, Manspeaker MP, Smith AS, Paulos CM, Thomas SN. A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8 T cells with enhanced tumor homing to improve cell therapy. Cell Reports. 42: 112175. PMID 36848287 DOI: 10.1016/j.celrep.2023.112175  0.397
2022 Riesenberg BP, Hunt EG, Tennant MD, Hurst KE, Andrews AM, Leddy LR, Neskey DM, Hill EG, Rangel Rivera GO, Paulos CM, Gao P, Thaxton JE. Stress-mediated attenuation of translation undermines T-cell activity in cancer. Cancer Research. PMID 36126165 DOI: 10.1158/0008-5472.CAN-22-1744  0.378
2022 Smith AS, Knochelmann HM, Wyatt MM, Rangel Rivera GO, Rivera-Reyes AM, Dwyer CJ, Ware MB, Cole AC, Neskey DM, Rubinstein MP, Liu B, Thaxton JE, Bartee E, Paulos CM. B cells imprint adoptively transferred CD8 T cells with enhanced tumor immunity. Journal For Immunotherapy of Cancer. 10. PMID 35017148 DOI: 10.1136/jitc-2021-003078  0.419
2021 Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, ... ... Paulos CM, et al. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell Reports. Medicine. 2: 100411. PMID 34755131 DOI: 10.1016/j.xcrm.2021.100411  0.337
2021 Chandrasekaran S, Funk CR, Kleber T, Paulos CM, Shanmugam M, Waller EK. Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ. Frontiers in Immunology. 12: 718621. PMID 34512641 DOI: 10.3389/fimmu.2021.718621  0.355
2021 Aicher TD, Van Huis CA, Hurd AR, Skalitzky DJ, Taylor CB, Beleh OM, Glick G, Toogood PL, Yang B, Zheng T, Huo C, Gao J, Qiao C, Tian X, Zhang J, ... ... Paulos CM, et al. Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer. Journal of Medicinal Chemistry. PMID 34499493 DOI: 10.1021/acs.jmedchem.1c00731  0.397
2021 Knochelmann HM, Rivera-Reyes AM, Wyatt MM, Smith AS, Chamness R, Dwyer CJ, Bobian M, Rangel Rivera GO, Horton JD, Lilly M, Romeo MJ, Timmers CD, Rubinstein MP, Neskey DM, Paulos CM. Modeling tumor-infiltrating lymphocyte expansion from established solid malignancies. Oncoimmunology. 10: 1959101. PMID 34408920 DOI: 10.1080/2162402X.2021.1959101  0.373
2021 Rangel Rivera GO, Knochelmann HM, Dwyer CJ, Smith AS, Wyatt MM, Rivera-Reyes AM, Thaxton JE, Paulos CM. Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy. Frontiers in Immunology. 12: 645242. PMID 33815400 DOI: 10.3389/fimmu.2021.645242  0.39
2021 Szopa IM, Granica M, Bujak JK, Łabędź A, Błaszczyk M, Paulos CM, Majchrzak-Kuligowska K. Effective Activation and Expansion of Canine Lymphocytes Using a Novel Nano-Sized Magnetic Beads Approach. Frontiers in Immunology. 12: 604066. PMID 33679741 DOI: 10.3389/fimmu.2021.604066  0.354
2020 Nelson MH, Knochelmann HM, Bailey SR, Huff LW, Bowers JS, Majchrzak-Kuligowska K, Wyatt MM, Rubinstein MP, Mehrotra S, Nishimura MI, Armeson KE, Giresi PG, Zilliox MJ, Broxmeyer HE, Paulos CM. Identification of human CD4 T cell populations with distinct antitumor activity. Science Advances. 6. PMID 32937437 DOI: 10.1126/Sciadv.Aba7443  0.486
2020 Ascierto PA, Bifulco C, Galon J, Garbe C, Khleif SN, McQuade J, Odunsi K, Okada H, Paulos CM, Quezada SA, Tawbi HA, Timmerman J, Trinchieri G, Butterfield LH, Puzanov I. The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019. Journal For Immunotherapy of Cancer. 8. PMID 32843491 DOI: 10.1136/Jitc-2020-000921  0.419
2020 Knochelmann HM, Dwyer CJ, Smith AS, Bowers JS, Wyatt MM, Nelson MH, Rangel Rivera GO, Horton JD, Krieg C, Armeson K, Lesinski GB, Rubinstein MP, Li Z, Paulos CM. IL-6 fuels durable memory for Th17 cell-mediated responses to tumors. Cancer Research. PMID 32561531 DOI: 10.1158/0008-5472.Can-19-3685  0.466
2020 Ansa-Addo EA, Huang HC, Riesenberg B, Iamsawat S, Borucki D, Nelson MH, Nam JH, Chung D, Paulos CM, Liu B, Yu XZ, Philpott C, Howe PH, Li Z. RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity. Science Advances. 6: eaaz3865. PMID 32523987 DOI: 10.1126/Sciadv.Aaz3865  0.461
2020 Dwyer CJ, Arhontoulis DC, Rivera GOR, Knochelmann HM, Smith AS, Wyatt MM, Rubinstein MP, Atkinson C, Thaxton JE, Neskey DM, Paulos CM. Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8 T cells. European Journal of Immunology. PMID 32383488 DOI: 10.1002/Eji.201948455  0.494
2020 Horton J, Knochelmann H, Armeson K, Bobian M, Paulos C, Kaczmar J, Neskey D. Abstract A17: Neutrophil-to-lymphocyte ratio predicts response to neoadjuvant presurgical PD-1 inhibition in oral cancer Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Aacrahns19-A17  0.322
2020 Knochelmann HM, Arhontoulis D, Rivera-Reyes A, Wyatt M, Neskey D, Paulos C. CD26 in checkpoint blockade-induced tumor immunity International Journal of Radiation Oncology Biology Physics. 106: 1132. DOI: 10.1016/J.Ijrobp.2019.11.361  0.38
2019 Bowers JS, Bailey SR, Rubinstein MP, Paulos CM, Camp ER. Genomics meets immunity in pancreatic cancer: Current research and future directions for pancreatic adenocarcinoma immunotherapy. Oncology Reviews. 13: 430. PMID 31456872 DOI: 10.4081/Oncol.2019.430  0.409
2019 Chakraborty P, Vaena SG, Thyagarajan K, Chatterjee S, Al-Khami A, Selvam SP, Nguyen H, Kang I, Wyatt MW, Baliga U, Hedley Z, Ngang RN, Guo B, Beeson GC, Husain S, ... Paulos CM, et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Reports. 28: 1879-1893.e7. PMID 31412253 DOI: 10.1016/J.Celrep.2019.07.044  0.483
2019 Horton JD, Knochelmann HM, Day TA, Paulos CM, Neskey DM. Immune Evasion by Head and Neck Cancer: Foundations for Combination Therapy. Trends in Cancer. 5: 208-232. PMID 30961829 DOI: 10.1016/J.Trecan.2019.02.007  0.344
2019 Dwyer CJ, Knochelmann HM, Smith AS, Wyatt MM, Rangel Rivera GO, Arhontoulis DC, Bartee E, Li Z, Rubinstein MP, Paulos CM. Fueling Cancer Immunotherapy With Common Gamma Chain Cytokines. Frontiers in Immunology. 10: 263. PMID 30842774 DOI: 10.3389/Fimmu.2019.00263  0.514
2019 Knochelmann H, Horton JD, Meek M, Krieg C, Timmers CD, Romeo M, Wrangle JM, Rubinstein MP, Young MRI, Neskey D, Paulos C. Immune signatures associated with response to neoadjuvant PD-1 blockade in oral cavity cancer. Journal of Clinical Oncology. 37: 6055-6055. DOI: 10.1200/Jco.2019.37.15_Suppl.6055  0.418
2019 Ware MB, McQuinn C, Mace TA, Bowers J, Shakya R, Farris B, Young G, Carson WE, Paulos CM, El-Rayes B, Lesinski GB. Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B59  0.5
2018 Knochelmann HM, Smith AS, Dwyer CJ, Wyatt MM, Mehrotra S, Paulos CM. CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies. Frontiers in Immunology. 9: 1740. PMID 30140266 DOI: 10.3389/Fimmu.2018.01740  0.48
2018 Eby JM, Smith AR, Riley TP, Cosgrove C, Ankney CM, Henning SW, Paulos CM, Garrett-Mayer E, Luiten RM, Nishimura MI, Baker BM, Le Poole IC. Molecular properties of gp100-reactive T cell receptors drive the cytokine profile and antitumor efficacy of transgenic host T cells. Pigment Cell & Melanoma Research. PMID 30009548 DOI: 10.1111/Pcmr.12724  0.51
2018 Ascierto PA, Brugarolas J, Buonaguro L, Butterfield LH, Carbone D, Daniele B, Ferris R, Fox BA, Galon J, Gridelli C, Kaufman HL, Klebanoff CA, Melero I, Nathan P, Paulos CM, et al. Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy). Journal For Immunotherapy of Cancer. 6: 69. PMID 29996914 DOI: 10.1186/S40425-018-0377-Z  0.38
2018 Hu X, Majchrzak K, Liu X, Wyatt MM, Spooner C, Moisan J, Zou W, Carter LL, Paulos CM. In vitro priming of adoptively transferred T cells with a RORγ agonist confers durable memory and stemness in vivo. Cancer Research. PMID 29769201 DOI: 10.1158/0008-5472.Can-17-3973  0.531
2018 Johnson CB, May BR, Riesenberg BP, Suriano S, Mehrotra S, Garret-Mayer E, Salem ML, Jeng EK, Wong HC, Paulos CM, Wrangle J, Cole DJ, Rubinstein MP. Enhanced lymphodepletion is insufficient to replace exogenous IL-2 or IL-15 therapy in augmenting the efficacy of adoptively transferred effector CD8+ T cells. Cancer Research. PMID 29636345 DOI: 10.1158/0008-5472.Can-17-2153  0.444
2018 Knochelmann HM, Dwyer CJ, Bailey SR, Amaya SM, Elston DM, Mazza-McCrann JM, Paulos CM. When worlds collide: Th17 and Treg cells in cancer and autoimmunity. Cellular & Molecular Immunology. PMID 29563615 DOI: 10.1038/S41423-018-0004-4  0.416
2018 Wrangle JM, Patterson A, Johnson CB, Neitzke DJ, Mehrotra S, Denlinger CE, Paulos CM, Li Z, Cole DJ, Rubinstein MP. IL-2 and Beyond in Cancer Immunotherapy. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 38: 45-68. PMID 29443657 DOI: 10.1089/Jir.2017.0101  0.416
2018 Scheffel MJ, Scurti G, Wyatt MM, Garrett-Mayer E, Paulos CM, Nishimura MI, Voelkel-Johnson C. N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner. Cancer Immunology, Immunotherapy : Cii. PMID 29396710 DOI: 10.1007/S00262-018-2120-5  0.504
2018 Riley JM, Cross AW, Paulos CM, Rubinstein MP, Wrangle J, Camp ER. The clinical implications of immunogenomics in colorectal cancer: A path for precision medicine. Cancer. PMID 29315503 DOI: 10.1002/Cncr.31214  0.336
2017 Bailey SR, Nelson MH, Majchrzak K, Bowers JS, Wyatt MM, Smith AS, Neal LR, Shirai K, Carpenito C, June CH, Zilliox MJ, Paulos CM. Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence. Nature Communications. 8: 1961. PMID 29213079 DOI: 10.1038/S41467-017-01867-9  0.525
2017 Scheffel MJ, Helke K, Lu P, Bowers JS, Ogretmen B, Garrett-Mayer E, Paulos CM, Voelkel-Johnson C. Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Scientific Reports. 7: 15552. PMID 29138469 DOI: 10.1038/S41598-017-15791-X  0.416
2017 Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, ... ... Paulos CM, et al. CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metabolism. PMID 29129787 DOI: 10.1016/J.Cmet.2017.10.006  0.51
2017 Bowers JS, Majchrzak K, Nelson MH, Aksoy BA, Wyatt MM, Smith AS, Bailey SR, Neal LR, Hammerbacher JE, Paulos CM. PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8(+) T Cells. Frontiers in Immunology. 8: 1221. PMID 29033940 DOI: 10.3389/Fimmu.2017.01221  0.515
2017 Wrangle J, Paulos CM, Smith TW, Nishimura MI, Rubinstein MP. Inducible Enhancement of T Cell Function and Anti-tumor Activity after Adoptive Transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28830671 DOI: 10.1016/J.Ymthe.2017.08.002  0.479
2017 Neal LR, Bailey SR, Wyatt MM, Bowers JS, Majchrzak K, Nelson MH, Haupt C, Paulos CM, Varela JC. The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies. Journal of Immunology Research and Therapy. 2: 68-79. PMID 28825053  0.389
2017 Rachidi S, Metelli A, Riesenberg B, Wu BX, Nelson MH, Wallace C, Paulos CM, Rubinstein MP, Garrett-Mayer E, Hennig M, Bearden DW, Yang Y, Liu B, Li Z. Platelets subvert T cell immunity against cancer via GARP-TGFβ axis. Science Immunology. 2. PMID 28763790 DOI: 10.1126/Sciimmunol.Aai7911  0.457
2017 Malik BT, Byrne KT, Vella JL, Zhang P, Shabaneh TB, Steinberg SM, Molodtsov AK, Bowers JS, Angeles CV, Paulos CM, Huang YH, Turk MJ. Resident memory T cells in the skin mediate durable immunity to melanoma. Science Immunology. 2. PMID 28738020 DOI: 10.1126/Sciimmunol.Aam6346  0.663
2017 Thaxton JE, Wallace C, Riesenberg B, Zhang Y, Paulos C, Beeson C, Liu B, Li Z. Modulation of Endoplasmic Reticulum Stress Controls CD4(+) T Cell Activation and Anti-tumor Function. Cancer Immunology Research. PMID 28642246 DOI: 10.1158/2326-6066.Cir-17-0081  0.436
2017 Majchrzak K, Nelson MH, Bowers JS, Bailey SR, Wyatt MM, Wrangle JM, Rubinstein MP, Varela JC, Li Z, Himes RA, Chan SSL, Paulos CM. β-catenin and PI3Kδ inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. Jci Insight. 2. PMID 28422756 DOI: 10.1172/Jci.Insight.90547  0.444
2017 Mehrotra S, Britten CD, Chin S, Garrett-Mayer E, Cloud CA, Li M, Scurti G, Salem ML, Nelson MH, Thomas MB, Paulos CM, Salazar AM, Nishimura MI, Rubinstein MP, Li Z, et al. Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer. Journal of Hematology & Oncology. 10: 82. PMID 28388966 DOI: 10.1186/S13045-017-0459-2  0.386
2017 Bowers JS, Nelson MH, Majchrzak K, Bailey SR, Rohrer B, Kaiser AD, Atkinson C, Gattinoni L, Paulos CM. Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion. Jci Insight. 2: e90772. PMID 28289713 DOI: 10.1172/Jci.Insight.90772  0.489
2017 Neitzke DJ, Bowers JS, Andrijauskaite K, O'Connell NS, Garrett-Mayer E, Wrangle J, Li Z, Paulos CM, Cole DJ, Rubinstein MP. Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Cancer Immunology, Immunotherapy : Cii. PMID 28280853 DOI: 10.1007/S00262-017-1965-3  0.39
2016 Hu X, Liu X, Moisan J, Wang Y, Lesch CA, Spooner C, Morgan RW, Zawidzka EM, Mertz D, Bousley D, Majchrzak K, Kryczek I, Taylor C, Van Huis C, Skalitzky D, ... ... Paulos CM, et al. Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity. Oncoimmunology. 5: e1254854. PMID 28123897 DOI: 10.1080/2162402X.2016.1254854  0.524
2016 Johnson CB, Wrangle J, Mehrotra S, Li Z, Paulos CM, Cole DJ, Surh CD, Rubinstein MP. Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy. Oncoimmunology. 5: e1122865. PMID 27467935 DOI: 10.1080/2162402X.2015.1122865  0.351
2016 Banerjee A, Thyagarajan K, Chatterjee S, Chakraborty P, Kesarwani P, Soloshchenko M, Hommrani MA, Andrijauskaite K, Moxley K, Janakiraman H, Scheffel MJ, Helke K, Armeson K, Palanisamy V, Rubinstein MP, ... ... Paulos CM, et al. Lack of p53 Augments Anti-Tumor Functions In Cytolytic T Cells. Cancer Research. PMID 27466285 DOI: 10.1158/0008-5472.Can-15-1798  0.485
2016 Varghese B, Paulos C, Low PS. Optimization of Folate-Targeted Immunotherapy for the Treatment of Experimental Arthritis. Inflammation. PMID 27206918 DOI: 10.1007/S10753-016-0366-7  0.532
2016 Nelson MH, Bowers JS, Bailey SR, Diven MA, Fugle CW, Kaiser AD, Wrzesinski C, Liu B, Restifo NP, Paulos CM. Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. Journal For Immunotherapy of Cancer. 4: 6. PMID 26885368 DOI: 10.1186/S40425-016-0110-8  0.494
2016 Majchrzak K, Nelson MH, Bailey SR, Bowers JS, Yu XZ, Rubinstein MP, Himes RA, Paulos CM. Exploiting IL-17-producing CD4(+) and CD8(+) T cells to improve cancer immunotherapy in the clinic. Cancer Immunology, Immunotherapy : Cii. PMID 26825102 DOI: 10.1007/S00262-016-1797-6  0.455
2016 Mehrotra S, Britten CD, Chin SH, Salem ML, Cloud C, Nelson MH, Paulos C, Garrett-Mayer E, Rubinstein MP, Li Z, Cole DJ. A feasibility and safety study of vaccination with Poly-ICLC and peptide-pulsed dendritic cells in patients with advanced pancreatic adenocarcinoma. Journal of Clinical Oncology. 34: e14579-e14579. DOI: 10.1200/Jco.2016.34.15_Suppl.E14579  0.357
2016 Hu X, Liu X, Moisan J, Paulos C, Wang Y, Spooner C, Lesch C, Morgan R, Mertz D, Bousley D, Taylor C, Huis CV, Skalitzky D, Aicher T, Toogood P, et al. Abstract 565: RORγ agonists regulate immune checkpoint receptors to enhance anti-tumor immunity Cancer Research. 76: 565-565. DOI: 10.1158/1538-7445.Am2016-565  0.47
2015 Su EW, Moore CJ, Suriano S, Johnson CB, Songalia N, Patterson A, Neitzke DJ, Andrijauskaite K, Garrett-Mayer E, Mehrotra S, Paulos CM, Doedens AL, Goldrath AW, Li Z, Cole DJ, et al. IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy. Science Translational Medicine. 7: 311ra170. PMID 26511507 DOI: 10.1126/Scitranslmed.Aac8155  0.333
2015 Andrijauskaite K, Suriano S, Cloud CA, Li M, Kesarwani P, Stefanik LS, Moxley KM, Salem ML, Garrett-Mayer E, Paulos CM, Mehrotra S, Kochenderfer JN, Cole DJ, Rubinstein MP. IL-12 conditioning improves retrovirally mediated transduction efficiency of CD8+ T cells. Cancer Gene Therapy. 22: 360-7. PMID 26182912 DOI: 10.1038/Cgt.2015.28  0.43
2015 Nelson MH, Diven MA, Huff LW, Paulos CM. Harnessing the Microbiome to Enhance Cancer Immunotherapy. Journal of Immunology Research. 2015: 368736. PMID 26101781 DOI: 10.1155/2015/368736  0.483
2015 Bowers JS, Nelson MH, Kundimi S, Bailey SR, Huff LW, Schwartz KM, Cole DJ, Rubinstein MP, Paulos CM. Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2546-57. PMID 25904754 DOI: 10.1158/1078-0432.Ccr-14-2294  0.498
2015 Rubinstein MP, Su EW, Suriano S, Cloud CA, Andrijauskaite K, Kesarwani P, Schwartz KM, Williams KM, Johnson CB, Li M, Scurti GM, Salem ML, Paulos CM, Garrett-Mayer E, Mehrotra S, et al. Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells. Cancer Immunology, Immunotherapy : Cii. 64: 539-49. PMID 25676709 DOI: 10.1007/S00262-015-1655-Y  0.494
2015 Frigault MJ, Lee J, Basil MC, Carpenito C, Motohashi S, Scholler J, Kawalekar OU, Guedan S, McGettigan SE, Posey AD, Ang S, Cooper LJ, Platt JM, Johnson FB, Paulos CM, et al. Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells. Cancer Immunology Research. 3: 356-67. PMID 25600436 DOI: 10.1158/2326-6066.Cir-14-0186  0.488
2015 Nelson MH, Kundimi S, Bowers JS, Rogers CE, Huff LW, Schwartz KM, Thyagarajan K, Little EC, Mehrotra S, Cole DJ, Rubinstein MP, Paulos CM. The inducible costimulator augments Tc17 cell responses to self and tumor tissue. Journal of Immunology (Baltimore, Md. : 1950). 194: 1737-47. PMID 25576595 DOI: 10.4049/Jimmunol.1401082  0.458
2015 Nelson MH, Paulos CM. Novel immunotherapies for hematologic malignancies. Immunological Reviews. 263: 90-105. PMID 25510273 DOI: 10.1111/Imr.12245  0.487
2015 Hu X, Moisan J, Majchrzak K, Lesch C, Wang Y, Sanchez B, Liu X, Morgan R, Mertz D, Bousley D, van Huis C, Skalitzky D, Taylor C, Aicher T, Toogood P, ... ... Paulos C, et al. RORgamma agonists enhance survival and memory of type 17 T cells and improve anti-tumor activity Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P23  0.466
2014 Chatterjee S, Thyagarajan K, Kesarwani P, Song JH, Soloshchenko M, Fu J, Bailey SR, Vasu C, Kraft AS, Paulos CM, Yu XZ, Mehrotra S. Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors. Cancer Research. 74: 6048-59. PMID 25205101 DOI: 10.1158/0008-5472.Can-14-1450  0.479
2014 Varghese B, Vlashi E, Xia W, Ayala Lopez W, Paulos CM, Reddy J, Xu LC, Low PS. Folate receptor-β in activated macrophages: ligand binding and receptor recycling kinetics. Molecular Pharmaceutics. 11: 3609-16. PMID 25166491 DOI: 10.1021/Mp500348E  0.684
2014 Bailey SR, Nelson MH, Himes RA, Li Z, Mehrotra S, Paulos CM. Th17 cells in cancer: the ultimate identity crisis. Frontiers in Immunology. 5: 276. PMID 24987392 DOI: 10.3389/Fimmu.2014.00276  0.507
2012 Rubinstein MP, Cloud CA, Garrett TE, Moore CJ, Schwartz KM, Johnson CB, Craig DH, Salem ML, Paulos CM, Cole DJ. Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. Journal of the American College of Surgeons. 214: 700-7; discussion 70. PMID 22360982 DOI: 10.1016/J.Jamcollsurg.2011.12.034  0.52
2011 Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, et al. A human memory T cell subset with stem cell-like properties. Nature Medicine. 17: 1290-7. PMID 21926977 DOI: 10.1038/Nm.2446  0.439
2011 Zhang Q, Wang H, Kantekure K, Paterson JC, Liu X, Schaffer A, Paulos C, Milone MC, Odum N, Turner S, Marafioti T, Wasik MA. Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS. Blood. 118: 3062-71. PMID 21765024 DOI: 10.1182/Blood-2011-01-332916  0.377
2010 Paulos CM, Carpenito C, Plesa G, Suhoski MM, Varela-Rohena A, Golovina TN, Carroll RG, Riley JL, June CH. The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells. Science Translational Medicine. 2: 55ra78. PMID 20980695 DOI: 10.1126/Scitranslmed.3000448  0.508
2010 Zhao Y, Moon E, Carpenito C, Paulos CM, Liu X, Brennan AL, Chew A, Carroll RG, Scholler J, Levine BL, Albelda SM, June CH. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Research. 70: 9053-61. PMID 20926399 DOI: 10.1158/0008-5472.Can-10-2880  0.479
2010 Paulos CM, June CH. Putting the brakes on BTLA in T cell-mediated cancer immunotherapy. The Journal of Clinical Investigation. 120: 76-80. PMID 20038807 DOI: 10.1172/Jci41811  0.487
2010 Wrzesinski C, Paulos CM, Kaiser A, Muranski P, Palmer DC, Gattinoni L, Yu Z, Rosenberg SA, Restifo NP. Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 1-7. PMID 19952961 DOI: 10.1097/Cji.0B013E3181B88Ffc  0.503
2009 Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nature Medicine. 15: 808-13. PMID 19525962 DOI: 10.1038/Nm.1982  0.399
2009 Hinrichs CS, Kaiser A, Paulos CM, Cassard L, Sanchez-Perez L, Heemskerk B, Wrzesinski C, Borman ZA, Muranski P, Restifo NP. Type 17 CD8+ T cells display enhanced antitumor immunity. Blood. 114: 596-9. PMID 19471017 DOI: 10.1182/Blood-2009-02-203935  0.501
2008 Paulos CM, Suhoski MM, Plesa G, Jiang T, Basu S, Golovina TN, Jiang S, Aqui NA, Powell DJ, Levine BL, Carroll RG, Riley JL, June CH. Adoptive immunotherapy: good habits instilled at youth have long-term benefits. Immunologic Research. 42: 182-96. PMID 18949448 DOI: 10.1007/S12026-008-8070-9  0.446
2008 Boni A, Muranski P, Cassard L, Wrzesinski C, Paulos CM, Palmer DC, Gattinoni L, Hinrichs CS, Chan CC, Rosenberg SA, Restifo NP. Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. Blood. 112: 4746-54. PMID 18799724 DOI: 10.1182/Blood-2008-07-169797  0.459
2008 Palmer DC, Chan CC, Gattinoni L, Wrzesinski C, Paulos CM, Hinrichs CS, Powell DJ, Klebanoff CA, Finkelstein SE, Fariss RN, Yu Z, Nussenblatt RB, Rosenberg SA, Restifo NP. Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 105: 8061-6. PMID 18523011 DOI: 10.1073/Pnas.0710929105  0.471
2008 Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 112: 362-73. PMID 18354038 DOI: 10.1182/Blood-2007-11-120998  0.511
2008 Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP. IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood. 111: 5326-33. PMID 18276844 DOI: 10.1182/Blood-2007-09-113050  0.422
2008 Abad JD, Wrzensinski C, Overwijk W, De Witte MA, Jorritsma A, Hsu C, Gattinoni L, Cohen CJ, Paulos CM, Palmer DC, Haanen JB, Schumacher TN, Rosenberg SA, Restifo NP, Morgan RA. T-cell receptor gene therapy of established tumors in a murine melanoma model. Journal of Immunotherapy (Hagerstown, Md. : 1997). 31: 1-6. PMID 18157006 DOI: 10.1097/Cji.0B013E31815C193F  0.472
2007 Paulos CM, Kaiser A, Wrzesinski C, Hinrichs CS, Cassard L, Boni A, Muranski P, Sanchez-Perez L, Palmer DC, Yu Z, Antony PA, Gattinoni L, Rosenberg SA, Restifo NP. Toll-like receptors in tumor immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 5280-9. PMID 17875756 DOI: 10.1158/1078-0432.Ccr-07-1378  0.513
2007 Paulos CM, Wrzesinski C, Kaiser A, Hinrichs CS, Chieppa M, Cassard L, Palmer DC, Boni A, Muranski P, Yu Z, Gattinoni L, Antony PA, Rosenberg SA, Restifo NP. Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling. The Journal of Clinical Investigation. 117: 2197-204. PMID 17657310 DOI: 10.1172/Jci32205  0.465
2007 Wrzesinski C, Paulos CM, Gattinoni L, Palmer DC, Kaiser A, Yu Z, Rosenberg SA, Restifo NP. Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells. The Journal of Clinical Investigation. 117: 492-501. PMID 17273561 DOI: 10.1172/Jci30414  0.503
2007 Paulos CM, Wrzesinski C, Kaiser A, Hinrichs CS, Chieppa M, Cassard L, Palmer DC, Boni A, Muranski P, Yu Z, Gattinoni L, Antony PA, Rosenberg SA, Restifo NP. Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling Journal of Clinical Investigation. 117: 3140-3140. DOI: 10.1172/Jci32205C1  0.434
2006 Paulos CM, Varghese B, Widmer WR, Breur GJ, Vlashi E, Low PS. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Research & Therapy. 8: R77. PMID 16646988 DOI: 10.1186/Ar1944  0.702
2006 Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, Sato N, Kaiser A, Hinrichs CS, Heinrichs C, Klebanoff CA, Tagaya Y, Restifo NP. Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. Journal of Immunology (Baltimore, Md. : 1950). 176: 5255-66. PMID 16621991 DOI: 10.4049/jimmunol.176.9.5255  0.365
2006 Boni A, Muranski P, Wrzesinski C, Kaiser A, Paulos C, Palmer D, Gattinoni L, Restifo NP. Partly MHC Matched Allogeneic Tumor Specific T Cells Mediate Tumor Regression without Inducing GVHD in Immunosuppressed Host. Blood. 108: 5210-5210. DOI: 10.1182/Blood.V108.11.5210.5210  0.479
2005 Wrzesinski C, Gattinoni L, Palmer DC, Paulos CM, Yu Z, Rosenberg SA, Restifo NP. Hematopoietic Stem Cell Transplant With Lymphodepletion Augments T Cell-based Adoptive Immunotherapy Journal of Immunotherapy. 28: 619. DOI: 10.1097/01.Cji.0000190968.11149.79  0.368
2004 Paulos CM, Reddy JA, Leamon CP, Turk MJ, Low PS. Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery. Molecular Pharmacology. 66: 1406-14. PMID 15371560 DOI: 10.1124/Mol.104.003723  0.694
2004 Paulos CM, Turk MJ, Breur GJ, Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Advanced Drug Delivery Reviews. 56: 1205-17. PMID 15094216 DOI: 10.1016/J.Addr.2004.01.012  0.669
2002 Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, Low PS. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis and Rheumatism. 46: 1947-55. PMID 12124880 DOI: 10.1002/Art.10405  0.64
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