Year |
Citation |
Score |
2012 |
Callihan P, Zitomer NC, Stoeling MV, Kennedy PC, Lynch KR, Riley RT, Hooks SB. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology. 62: 988-96. PMID 22016110 DOI: 10.1016/J.Neuropharm.2011.10.005 |
0.693 |
|
2011 |
East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A |
0.548 |
|
2011 |
Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817 |
0.632 |
|
2011 |
Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552 |
0.712 |
|
2010 |
Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H |
0.657 |
|
2009 |
Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015 |
0.727 |
|
2007 |
Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172 |
0.706 |
|
Show low-probability matches. |