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Edward J. Merino, Ph.D. - Publications

Affiliations: 
2005 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural and Chemical Biology of the Transcriptome
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhu H, Mishra R, Yuan L, Abdul Salam SF, Liu J, Gray G, Sterling AD, Wunderlich M, Landero-Figueroa J, Garrett JT, Merino EJ. Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. Chemmedchem. PMID 31696673 DOI: 10.1002/Cmdc.201900481  0.426
2019 Nassar N, Hegde SN, Gasilina A, Wunderlich M, Premnauth G, Merino E, Lin Y, Ahmadian R, Zheng Y, Mizukawa B, Privette Vinnedge L, Cancelas JA. The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph+(BCR-ABL1) B-ALL Blood. 134: 4647-4647. DOI: 10.1182/Blood-2019-130250  0.322
2018 Liu J, Zhu H, Premnauth G, Earnest KG, Hahn P, Gray G, Queenan JA, Prevette LE, AbdulSalam SF, Kadekaro AL, Merino EJ. UV cell stress induces oxidative cyclization of a protective reagent for DNA damage reduction in skin explants. Free Radical Biology & Medicine. PMID 30605714 DOI: 10.1016/J.Freeradbiomed.2018.12.037  0.456
2018 Yuan L, Mishra R, Patel H, Abdulsalam S, Greis KD, Kadekaro AL, Merino EJ, Garrett JT. Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma. Journal of Cancer. 9: 4665-4676. PMID 30588251 DOI: 10.7150/Jca.27295  0.365
2018 Gong J, Solivio MJ, Merino EJ, Landero Figueroa JA. Application of Molecular Mass Spectrometry for The Structural Characterization of a DNA-Protein Cross-Links Journal of the Mexican Chemical Society. 62. DOI: 10.29356/Jmcs.V62I2.405  0.766
2017 AbdulSalam SF, Gurjar PN, Zhu H, Johnson ES, Liu J, Kadekaro AL, Landero-Figueroa J, Merino EJ. Self-cyclizing Antioxidants to Prevent DNA Damage Caused by Hydroxyl Radical. Chembiochem : a European Journal of Chemical Biology. PMID 28810083 DOI: 10.1002/Cbic.201700341  0.431
2017 Horwath M, Bell-Horwath T, Lescano V, Krishnan K, Merino E, Deepe GS. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem : a European Journal of Chemical Biology. PMID 28783875 DOI: 10.1002/Cbic.201700105  0.728
2017 Kadekaro A, Ernest K, Thowfeik F, Vadukoot A, Zhou L, Yang K, Zhang Y, Merino E. 834 Exploiting oxidative stress to target melanoma Journal of Investigative Dermatology. 137: S143. DOI: 10.1016/J.Jid.2017.02.859  0.744
2016 Cushion MT, Collins MS, Sesterhenn T, Porollo A, Vadukoot AK, Merino EJ. Functional Characterization of Pneumocystis carinii Inositol Transporter 1. Mbio. 7. PMID 27965450 DOI: 10.1128/Mbio.01851-16  0.725
2016 AbdulSalam SF, Thowfeik FS, Merino EJ. Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability. Biochemistry. PMID 27582430 DOI: 10.1021/Acs.Biochem.6B00703  0.456
2015 Thowfeik FS, Abdul Salam SF, Wunderlich M, Wyder M, Greis KD, Kadekaro AL, Mulloy JC, Merino EJ. A ROS-activatable agent elicits homologous recombination DNA repair and synergizes with pathway compounds. Chembiochem : a European Journal of Chemical Biology. PMID 26419938 DOI: 10.1002/Cbic.201500304  0.449
2015 Borland KM, AbdulSalam SF, Solivio MJ, Burke MP, Wolfkiel PR, Lawson SM, Stockman CA, Andersen JM, Smith S, Tolstolutskaya JN, Gurjar PN, Bercz AP, Merino EJ, Litosh VA. Base-modified thymidines capable of terminating DNA synthesis are novel bioactive compounds with activity in cancer cells. Bioorganic & Medicinal Chemistry. 23: 1869-81. PMID 25778768 DOI: 10.1016/J.Bmc.2015.01.057  0.783
2015 Gong J, Solivio MJ, Merino EJ, Caruso JA, Landero-Figueroa JA. Developing ICP-MS/MS for the detection and determination of synthetic DNA-protein crosslink models via phosphorus and sulfur detection. Analytical and Bioanalytical Chemistry. 407: 2433-7. PMID 25651903 DOI: 10.1007/S00216-015-8504-X  0.777
2014 Vadukoot AK, AbdulSalam SF, Wunderlich M, Pullen ED, Landero-Figueroa J, Mulloy JC, Merino EJ. Design of a hydrogen peroxide-activatable agent that specifically targets cancer cells. Bioorganic & Medicinal Chemistry. 22: 6885-92. PMID 25464887 DOI: 10.1016/J.Bmc.2014.10.029  0.783
2014 Amato E, Bankemper T, Kidney R, Do T, Onate A, Thowfeik FS, Merino EJ, Paula S, Ma L. Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors. Bioorganic & Medicinal Chemistry. 22: 126-34. PMID 24345481 DOI: 10.1016/J.Bmc.2013.11.045  0.332
2014 Hufziger KT, Thowfeik FS, Charboneau DJ, Nieto I, Dougherty WG, Kassel WS, Dudley TJ, Merino EJ, Papish ET, Paul JJ. Ruthenium dihydroxybipyridine complexes are tumor activated prodrugs due to low pH and blue light induced ligand release. Journal of Inorganic Biochemistry. 130: 103-11. PMID 24184694 DOI: 10.1016/J.Jinorgbio.2013.10.008  0.302
2013 Chitta KR, Landero-Figueroa JA, Kodali P, Caruso JA, Merino EJ. Identification of selenium-containing proteins in HEK 293 kidney cells using multiple chromatographies, LC-ICPMS and nano-LC-ESIMS. Talanta. 114: 25-31. PMID 23953436 DOI: 10.1016/J.Talanta.2013.03.003  0.309
2013 Bell-Horwath TR, Vadukoot AK, Thowfeik FS, Li G, Wunderlich M, Mulloy JC, Merino EJ. Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia. Bioorganic & Medicinal Chemistry Letters. 23: 2951-4. PMID 23578690 DOI: 10.1016/J.Bmcl.2013.03.048  0.707
2013 Chitta KR, Landero Figueroa JA, Caruso JA, Merino EJ. Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygen species and phosphorylated proteins. Metallomics : Integrated Biometal Science. 5: 673-85. PMID 23503360 DOI: 10.1039/C3Mt20213E  0.352
2012 Jones AR, Bell-Horwath TR, Li G, Rollmann SM, Merino EJ. Novel oxidatively activated agents modify DNA and are enhanced by ercc1 silencing. Chemical Research in Toxicology. 25: 2542-52. PMID 23051149 DOI: 10.1021/Tx300337J  0.779
2012 Solivio MJ, Nemera DB, Sallans L, Merino EJ. Biologically relevant oxidants cause bound proteins to readily oxidatively cross-link at Guanine. Chemical Research in Toxicology. 25: 326-36. PMID 22216745 DOI: 10.1021/Tx200376E  0.785
2011 Li G, Bell T, Merino EJ. Oxidatively activated DNA-modifying agents for selective cytotoxicity. Chemmedchem. 6: 869-75. PMID 21374823 DOI: 10.1002/Cmdc.201100014  0.482
2010 Alp O, Merino EJ, Caruso JA. Arsenic-induced protein phosphorylation changes in HeLa cells. Analytical and Bioanalytical Chemistry. 398: 2099-107. PMID 20803194 DOI: 10.1007/S00216-010-4128-3  0.311
2010 Solivio MJ, Joy TJ, Sallans L, Merino EJ. Copper generated reactive oxygen leads to formation of lysine-DNA adducts. Journal of Inorganic Biochemistry. PMID 20684846 DOI: 10.1016/J.Jinorgbio.2010.05.006  0.794
2010 Solivio MJ, Joy TJ, Sallans L, Merino EJ. Copper generated reactive oxygen leads to formation of lysine-DNA adducts. Journal of Inorganic Biochemistry. 104: 1000-5. PMID 20684045  0.798
2009 Merino EJ, Davis ML, Barton JK. Common mitochondrial DNA mutations generated through DNA-mediated charge transport. Biochemistry. 48: 660-6. PMID 19128037 DOI: 10.1021/Bi801570J  0.403
2008 Merino EJ, Boal AK, Barton JK. Biological contexts for DNA charge transport chemistry. Current Opinion in Chemical Biology. 12: 229-37. PMID 18314014 DOI: 10.1016/J.Cbpa.2008.01.046  0.389
2008 Merino EJ, Barton JK. DNA oxidation by charge transport in mitochondria. Biochemistry. 47: 1511-7. PMID 18189417 DOI: 10.1021/Bi701775S  0.436
2007 Augustyn KE, Merino EJ, Barton JK. A role for DNA-mediated charge transport in regulating p53: Oxidation of the DNA-bound protein from a distance. Proceedings of the National Academy of Sciences of the United States of America. 104: 18907-12. PMID 18025460 DOI: 10.1073/Pnas.0709326104  0.436
2007 Merino EJ, Barton JK. Oxidation by DNA charge transport damages conserved sequence block II, a regulatory element in mitochondrial DNA. Biochemistry. 46: 2805-11. PMID 17302436 DOI: 10.1021/Bi062024+  0.428
2006 Wilkinson KA, Merino EJ, Weeks KM. Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution. Nature Protocols. 1: 1610-6. PMID 17406453 DOI: 10.1038/Nprot.2006.249  0.567
2005 Merino EJ, Weeks KM. Facile conversion of aptamers into sensors using a 2'-ribose-linked fluorophore. Journal of the American Chemical Society. 127: 12766-7. PMID 16159247 DOI: 10.1021/Ja053189T  0.552
2005 Wilkinson KA, Merino EJ, Weeks KM. RNA SHAPE chemistry reveals nonhierarchical interactions dominate equilibrium structural transitions in tRNA(Asp) transcripts. Journal of the American Chemical Society. 127: 4659-67. PMID 15796531 DOI: 10.1021/Ja0436749  0.563
2005 Merino EJ, Wilkinson KA, Coughlan JL, Weeks KM. RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE). Journal of the American Chemical Society. 127: 4223-31. PMID 15783204 DOI: 10.1021/Ja043822V  0.571
2004 John DM, Merino EJ, Weeks KM. Mechanics of DNA flexibility visualized by selective 2'-amine acylation at nucleotide bulges. Journal of Molecular Biology. 337: 611-9. PMID 15019781 DOI: 10.1016/J.Jmb.2004.01.029  0.623
2003 Merino EJ, Weeks KM. Fluorogenic resolution of ligand binding by a nucleic acid aptamer. Journal of the American Chemical Society. 125: 12370-1. PMID 14531655 DOI: 10.1021/Ja035299A  0.547
2002 Chamberlin SI, Merino EJ, Weeks KM. Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups. Proceedings of the National Academy of Sciences of the United States of America. 99: 14688-93. PMID 12403820 DOI: 10.1073/Pnas.212527799  0.712
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