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William T. Dauer - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
neurology
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li J, Levin DS, Kim AJ, Pappas SS, Dauer WT. TorsinA restoration in a mouse model identifies a critical therapeutic window for DYT1 dystonia. The Journal of Clinical Investigation. PMID 33529159 DOI: 10.1172/JCI139606  0.349
2020 Li J, Liang CC, Pappas SS, Dauer WT. TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 9. PMID 32202496 DOI: 10.7554/Elife.54285  0.461
2019 Shin JY, Hernandez-Ono A, Fedotova T, Östlund C, Lee MJ, Gibeley SB, Liang CC, Dauer WT, Ginsberg HN, Worman HJ. Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis. The Journal of Clinical Investigation. 130. PMID 31408437 DOI: 10.1172/Jci129769  0.315
2019 Bohnen NI, Kanel P, Zhou Z, Koeppe RA, Frey KA, Dauer WT, Albin RL, Müller MLTM. Cholinergic system changes of falls and freezing of gait in Parkinson disease. Annals of Neurology. PMID 30720884 DOI: 10.1002/Ana.25430  0.33
2018 Albin RL, Surmeier DJ, Tubert C, Sarter M, Müller MLTM, Bohnen NI, Dauer WT. Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30398673 DOI: 10.1002/mds.27540  0.366
2018 Pappas SS, Li J, LeWitt TM, Kim JK, Monani UR, Dauer WT. A cell autonomous torsinA requirement for cholinergic neuron survival and motor control. Elife. 7. PMID 30117805 DOI: 10.7554/Elife.36691  0.409
2018 Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway. Scientific Reports. 8: 3455. PMID 29472595 DOI: 10.1038/S41598-018-21931-8  0.369
2018 Weisheit CE, Pappas SS, Dauer WT. Inherited dystonias: clinical features and molecular pathways. Handbook of Clinical Neurology. 147: 241-254. PMID 29325615 DOI: 10.1016/B978-0-444-63233-3.00016-6  0.45
2018 Pappas SS, Li J, LeWitt TM, Kim J, Monani UR, Dauer WT. Author response: A cell autonomous torsinA requirement for cholinergic neuron survival and motor control Elife. DOI: 10.7554/Elife.36691.024  0.311
2017 Pappas SS, Liang CC, Kim S, Rivera CO, Dauer WT. TorsinA dysfunction causes persistent neuronal nuclear pore defects. Human Molecular Genetics. PMID 29186574 DOI: 10.1093/Hmg/Ddx405  0.452
2017 Yellajoshyula D, Liang CC, Pappas SS, Penati S, Yang A, Mecano R, Kumaran R, Jou S, Cookson MR, Dauer WT. The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage. Developmental Cell. 42: 52-67.e4. PMID 28697333 DOI: 10.1016/J.Devcel.2017.06.009  0.375
2017 DeSimone JC, Pappas SS, Febo M, Burciu RG, Shukla P, Colon-Perez LM, Dauer WT, Vaillancourt DE. Forebrain knock-out of torsinA reduces striatal free-water and impairs whole-brain functional connectivity in a symptomatic mouse model of DYT1 dystonia. Neurobiology of Disease. PMID 28673740 DOI: 10.1016/J.Nbd.2017.06.015  0.438
2016 Shin JY, Méndez-López I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ. Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Human Molecular Genetics. PMID 27798115 DOI: 10.1093/Hmg/Ddw368  0.32
2016 Shakkottai VG, Batla A, Bhatia K, Dauer WT, Dresel C, Niethammer M, Eidelberg D, Raike RS, Smith Y, Jinnah HA, Hess EJ, Meunier S, Hallett M, Fremont R, Khodakhah K, et al. Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia. Cerebellum (London, England). PMID 27734238 DOI: 10.1007/S12311-016-0825-6  0.411
2016 Tanabe LM, Liang CC, Dauer WT. Neuronal Nuclear Membrane Budding Occurs during a Developmental Window Modulated by Torsin Paralogs. Cell Reports. 16: 3322-33. PMID 27653693 DOI: 10.1016/J.Celrep.2016.08.044  0.737
2016 Kett LR, Dauer WT. Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27619535 DOI: 10.1002/mds.26797  0.419
2016 Dinov ID, Heavner B, Tang M, Glusman G, Chard K, Darcy M, Madduri R, Pa J, Spino C, Kesselman C, Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J, ... ... Dauer W, et al. Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations. Plos One. 11: e0157077. PMID 27494614 DOI: 10.1371/Journal.Pone.0157077  0.318
2015 Jankovic J, Bressman S, Dauer W, Kang UJ. Clinical and scientific perspectives on movement disorders: Stanley Fahn's contributions. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 1862-9. PMID 26477883 DOI: 10.1002/Mds.26445  0.322
2015 Weisheit CE, Dauer WT. A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation. Human Molecular Genetics. 24: 6459-72. PMID 26370418 DOI: 10.1093/hmg/ddv355  0.429
2015 Goodchild RE, Buchwalter AL, Naismith TV, Holbrook K, Billion K, Dauer WT, Liang CC, Dear ML, Hanson PI. Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum. Journal of Cell Science. PMID 26092934 DOI: 10.1242/Jcs.167452  0.313
2015 Pappas SS, Darr K, Holley SM, Cepeda C, Mabrouk OS, Wong JM, LeWitt TM, Paudel R, Houlden H, Kennedy RT, Levine MS, Dauer WT. Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons. Elife. 4. PMID 26052670 DOI: 10.7554/Elife.08352  0.427
2015 Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5724-42. PMID 25855184 DOI: 10.1523/Jneurosci.0632-14.2015  0.457
2015 VanGompel MJ, Nguyen KC, Hall DH, Dauer WT, Rose LS. A novel function for the Caenorhabditis elegans torsin OOC-5 in nucleoporin localization and nuclear import. Molecular Biology of the Cell. 26: 1752-63. PMID 25739455 DOI: 10.1091/Mbc.E14-07-1239  0.428
2015 Dauer W. Inherited isolated dystonia: clinical genetics and gene function. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 807-16. PMID 25155315 DOI: 10.1007/s13311-014-0297-7  0.346
2015 Dauer W. Inherited isolated dystonia: clinical genetics and gene function. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 807-16. PMID 25155315 DOI: 10.1007/s13311-014-0297-7  0.346
2015 Pappas SS, Darr K, Holley SM, Cepeda C, Mabrouk OS, Wong JT, LeWitt TM, Paudel R, Houlden H, Kennedy RT, Levine MS, Dauer WT. Author response: Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons Elife. DOI: 10.7554/Elife.08352.023  0.372
2014 Bohnen NI, Müller MLTM, Dauer WT, Albin RL. Parkinson's Disease: What role do pedunculopontine nucleus cholinergic neurons play? Future Neurology. 9: 5-8. PMID 28845134 DOI: 10.2217/fnl.13.61  0.372
2014 Dauer WT. Neurogenetic disease: genes, mechanisms, and future promise. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 697-8. PMID 25261113 DOI: 10.1007/s13311-014-0303-0  0.407
2014 Worman HJ, Dauer WT. The nuclear envelope: an intriguing focal point for neurogenetic disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 764-72. PMID 25119890 DOI: 10.1007/S13311-014-0296-8  0.404
2014 Maric M, Haugo AC, Dauer W, Johnson D, Roller RJ. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins. Virology. 460: 128-37. PMID 25010278 DOI: 10.1016/J.Virol.2014.05.010  0.305
2014 Pappas SS, Leventhal DK, Albin RL, Dauer WT. Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits. Current Topics in Developmental Biology. 109: 97-169. PMID 24947237 DOI: 10.1016/B978-0-12-397920-9.00001-9  0.41
2014 Liang CC, Tanabe LM, Jou S, Chi F, Dauer WT. TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration. The Journal of Clinical Investigation. 124: 3080-92. PMID 24937429 DOI: 10.1172/Jci72830  0.754
2014 Shin JY, Le Dour C, Sera F, Iwata S, Homma S, Joseph LC, Morrow JP, Dauer WT, Worman HJ. Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice. Nucleus (Austin, Tex.). 5: 260-459. PMID 24859316 DOI: 10.4161/Nucl.29227  0.359
2014 Mehanna R, Bohnen N, Sarter M, Muller M, Dauer W, Albin R, Arbor A. Gait speed in Parkinson disease correlates with cholinergic degenerationAuthor Response Neurology. 82: 1568-1569. PMID 24778286 DOI: 10.1212/01.Wnl.0000446971.02565.F1  0.328
2014 Albin RL, Dauer WT. Magic shotgun for Parkinson's disease? Brain : a Journal of Neurology. 137: 1274-5. PMID 24771397 DOI: 10.1093/brain/awu076  0.355
2014 Dauer WT, Guo M. Multiplying messages LRRK beneath Parkinson disease. Cell. 157: 291-3. PMID 24725399 DOI: 10.1016/j.cell.2014.03.043  0.359
2014 Shin JY, Dauer WT, Worman HJ. Lamina-associated polypeptide 1: protein interactions and tissue-selective functions. Seminars in Cell & Developmental Biology. 29: 164-8. PMID 24508913 DOI: 10.1016/J.Semcdb.2014.01.010  0.422
2013 Santos M, Rebelo S, Van Kleeff PJ, Kim CE, Dauer WT, Fardilha M, da Cruz E Silva OA, da Cruz E Silva EF. The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. Plos One. 8: e76788. PMID 24116158 DOI: 10.1371/Journal.Pone.0076788  0.57
2013 Shin JY, Méndez-López I, Wang Y, Hays AP, Tanji K, Lefkowitch JH, Schulze PC, Worman HJ, Dauer WT. Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Developmental Cell. 26: 591-603. PMID 24055652 DOI: 10.1016/J.Devcel.2013.08.012  0.354
2013 Ledoux MS, Dauer WT, Warner TT. Emerging common molecular pathways for primary dystonia. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 968-81. PMID 23893453 DOI: 10.1002/mds.25547  0.404
2013 Orenstein SJ, Kuo SH, Tasset I, Arias E, Koga H, Fernandez-Carasa I, Cortes E, Honig LS, Dauer W, Consiglio A, Raya A, Sulzer D, Cuervo AM. Interplay of LRRK2 with chaperone-mediated autophagy. Nature Neuroscience. 16: 394-406. PMID 23455607 DOI: 10.1038/Nn.3350  0.464
2012 Albin RL, Dauer WT. Parkinson syndrome. Heterogeneity of etiology; heterogeneity of pathogenesis? Neurology. 79: 202-3. PMID 22722622 DOI: 10.1212/WNL.0b013e31825dd3d0  0.392
2012 Kett LR, Dauer WT. Leucine-rich repeat kinase 2 for beginners: six key questions. Cold Spring Harbor Perspectives in Medicine. 2: a009407. PMID 22393539 DOI: 10.1101/cshperspect.a009407  0.345
2012 Tanabe LM, Martin C, Dauer WT. Genetic background modulates the phenotype of a mouse model of DYT1 dystonia. Plos One. 7: e32245. PMID 22393392 DOI: 10.1371/Journal.Pone.0032245  0.739
2012 Kett LR, Boassa D, Ho CC, Rideout HJ, Hu J, Terada M, Ellisman M, Dauer WT. LRRK2 Parkinson disease mutations enhance its microtubule association. Human Molecular Genetics. 21: 890-9. PMID 22080837 DOI: 10.1093/Hmg/Ddr526  0.625
2011 Droggiti A, Ho CC, Stefanis L, Dauer WT, Rideout HJ. Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death. Journal of Neurochemistry. 119: 630-43. PMID 21883213 DOI: 10.1111/j.1471-4159.2011.07444.x  0.588
2011 UluÄŸ AM, Vo A, Argyelan M, Tanabe L, Schiffer WK, Dewey S, Dauer WT, Eidelberg D. Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 6638-43. PMID 21464304 DOI: 10.1073/Pnas.1016445108  0.761
2011 Martin JN, Wolken N, Brown T, Dauer WT, Ehrlich ME, Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy. 18: 666-73. PMID 21368900 DOI: 10.1038/Gt.2011.10  0.394
2010 Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT. A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 9861-6. PMID 20457914 DOI: 10.1073/Pnas.0912877107  0.649
2010 Dauer W, Ho CCY. The biology and pathology of the familial Parkinson's disease protein LRRK2 Movement Disorders. 25: S40-S43. PMID 20187256 DOI: 10.1002/mds.22717  0.388
2009 Jorgensen ND, Peng Y, Ho CC, Rideout HJ, Petrey D, Liu P, Dauer WT. The WD40 domain is required for LRRK2 neurotoxicity. Plos One. 4: e8463. PMID 20041156 DOI: 10.1371/Journal.Pone.0008463  0.603
2009 Dauer WT, Worman HJ. The nuclear envelope as a signaling node in development and disease. Developmental Cell. 17: 626-38. PMID 19922868 DOI: 10.1016/J.Devcel.2009.10.016  0.371
2009 Tanabe LM, Kim CE, Alagem N, Dauer WT. Primary dystonia: molecules and mechanisms. Nature Reviews. Neurology. 5: 598-609. PMID 19826400 DOI: 10.1038/Nrneurol.2009.160  0.74
2009 Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1011-6. PMID 19176810 DOI: 10.1523/JNEUROSCI.5175-08.2009  0.605
2008 Akman HO, Dorado B, López LC, García-Cazorla A, Vilà MR, Tanabe LM, Dauer WT, Bonilla E, Tanji K, Hirano M. Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. Human Molecular Genetics. 17: 2433-40. PMID 18467430 DOI: 10.1093/Hmg/Ddn143  0.728
2007 Cookson MR, Dauer W, Dawson T, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11865-8. PMID 17978026 DOI: 10.1523/Jneurosci.3695-07.2007  0.324
2005 Goodchild RE, Kim CE, Dauer WT. Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron. 48: 923-32. PMID 16364897 DOI: 10.1016/J.Neuron.2005.11.010  0.627
2004 Goodchild RE, Dauer WT. Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation. Proceedings of the National Academy of Sciences of the United States of America. 101: 847-52. PMID 14711988 DOI: 10.1073/pnas.0304375101  0.378
1988 Bissette G, Dauer WT, Kilts CD, O'Connor L, Nemeroff CB. The effect of the stereoisomers of butaclamol on neurotensin content in discrete regions of the rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 1: 329-35. PMID 2472151  0.311
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