Daniel K. Nomura, Ph.D. - Publications

2011- Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology University of California, Berkeley, Berkeley, CA 
Chemical Biology

122 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ibars M, Maier MT, Yulyaningsih E, Perez L, Cheang R, Vilhelmsson A, Louie SM, Wegner SA, Yuan X, Eltzschig HK, Hopf FW, Nomura DK, Koliwad SK, Xu AW. Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking. American Journal of Physiology. Endocrinology and Metabolism. PMID 32045262 DOI: 10.1152/ajpendo.00218.2019  1
2019 Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD. Erratum for Ahyong et al., "A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics". Msphere. 4. PMID 31776245 DOI: 10.1128/mSphere.00848-19  0.52
2019 Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD. A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics. Msphere. 4. PMID 31722991 DOI: 10.1128/mSphere.00536-19  0.52
2019 Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. PMID 31634900 DOI: 10.1038/s41586-019-1705-2  1
2019 Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nature Cell Biology. PMID 31548609 DOI: 10.1038/s41556-019-0391-5  1
2019 Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK. Covalent targeting of the vacuolar H-ATPase activates autophagy via mTORC1 inhibition. Nature Chemical Biology. PMID 31285595 DOI: 10.1038/s41589-019-0308-4  1
2019 Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, ... ... Nomura DK, et al. Harnessing the anti-cancer natural product nimbolide for targeted protein degradation. Nature Chemical Biology. PMID 31209351 DOI: 10.1038/s41589-019-0304-8  1
2019 Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ, Nomura DK. Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells. Cell Chemical Biology. PMID 31080076 DOI: 10.1016/j.chembiol.2019.03.016  1
2019 Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. Acs Chemical Biology. PMID 31059647 DOI: 10.1021/acschembio.8b01083  1
2019 Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, ... Nomura DK, et al. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature. PMID 30842661 DOI: 10.1038/s41586-019-1005-x  1
2019 Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, ... ... Nomura DK, et al. Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Science Translational Medicine. 11. PMID 30728288 DOI: 10.1126/scitranslmed.aau5758  0.84
2019 Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nature Communications. 10: 163. PMID 30635563 DOI: 10.1038/s41467-018-08046-4  1
2019 Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. Journal of Cell Science. 132. PMID 30578317 DOI: 10.1242/jcs.223453  1
2018 Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ. Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Cell Chemical Biology. PMID 30686757 DOI: 10.1016/j.chembiol.2018.11.016  0.84
2018 Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, ... ... Nomura DK, et al. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells. European Journal of Medicinal Chemistry. 163: 722-735. PMID 30576903 DOI: 10.1016/j.ejmech.2018.11.050  1
2018 Zhou M, Ford B, Lee D, Tindula G, Huen K, Tran V, Bradman A, Gunier R, Eskenazi B, Nomura DK, Holland N. Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women. Frontiers in Public Health. 6: 298. PMID 30406068 DOI: 10.3389/fpubh.2018.00298  1
2018 Fernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM. Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 30401738 DOI: 10.1073/pnas.1807958115  1
2018 Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, et al. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nature Chemical Biology. 14: 1021-1031. PMID 30327559 DOI: 10.1038/s41589-018-0132-2  1
2018 Nomura DK, Maimone TJ. Target Identification of Bioactive Covalently Acting Natural Products. Current Topics in Microbiology and Immunology. PMID 30105423 DOI: 10.1007/82_2018_121  1
2018 Tam AB, Roberts LS, Chandra V, Rivera IG, Nomura DK, Forbes DJ, Niwa M. The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms. Developmental Cell. 46: 327-343.e7. PMID 30086303 DOI: 10.1016/j.devcel.2018.04.023  1
2018 Counihan JL, Wiggenhorn AL, Anderson KE, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target. Acs Chemical Biology. PMID 30004670 DOI: 10.1021/acschembio.8b00381  1
2018 Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, ... ... Nomura DK, et al. Ablation of PM20D1 reveals -acyl amino acid control of metabolism and nociception. Proceedings of the National Academy of Sciences of the United States of America. PMID 29967167 DOI: 10.1073/pnas.1803389115  1
2018 Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, ... Nomura DK, et al. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nature Cell Biology. PMID 29941929 DOI: 10.1038/s41556-018-0122-3  1
2018 Counihan JL, Grossman EA, Nomura DK. Cancer Metabolism: Current Understanding and Therapies. Chemical Reviews. PMID 29939018 DOI: 10.1021/acs.chemrev.7b00775  1
2018 Maier MT, Vilhelmsson A, Louie SM, Vagena E, Nomura DK, Koliwad SK, Xu AW. Regulation of hepatic lipid accumulation and distribution by Agouti-related protein in male mice. Endocrinology. PMID 29750244 DOI: 10.1210/en.2018-00040  1
2018 Lin H, Long JZ, Roche AM, Svensson KJ, Dou F, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CM, Louie S, Nomura DK, Spiegelman BM, Griffin PR, et al. Discovery of Hydrolysis-resistant Isoindoline N-Acyl Amino Acid Analogs that Stimulate Mitochondrial Respiration. Journal of Medicinal Chemistry. PMID 29533650 DOI: 10.1021/acs.jmedchem.8b00029  1
2018 Prasse C, Ford B, Nomura DK, Sedlak DL. Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463747 DOI: 10.1073/pnas.1715821115  1
2018 Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R. Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus. Nature. PMID 29320479 DOI: 10.1038/nature25188  1
2018 Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N. Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange. Journal of Chemical Information and Modeling. PMID 29320178 DOI: 10.1021/acs.jcim.7b00399  1
2017 Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA. A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes. Developmental Cell. PMID 29275994 DOI: 10.1016/j.devcel.2017.11.020  1
2017 De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE. Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Reports. 21: 2031-2038. PMID 29166595 DOI: 10.1016/j.celrep.2017.10.088  1
2017 Lue HW, Podolak J, Kolahi K, Cheng L, Rao S, Garg D, Xue CH, Rantala JK, Tyner JW, Thornburg KL, Martinez-Acevedo A, Liu JJ, Amling CL, Truillet C, Louie SM, ... ... Nomura DK, et al. Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade. Genes & Development. PMID 29138276 DOI: 10.1101/gad.305292.117  1
2017 Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK. Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products. Cell Chemical Biology. PMID 28919038 DOI: 10.1016/j.chembiol.2017.08.013  1
2017 Anderson KE, To M, Olzmann JA, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor that Impairs Breast Cancer Pathogenicity. Acs Chemical Biology. PMID 28892616 DOI: 10.1021/acschembio.7b00711  0.84
2017 Chomvong K, Benjamin DI, Nomura DK, Cate JHD. Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae. Mbio. 8. PMID 28790206 DOI: 10.1128/mBio.00855-17  1
2017 Chen TC, Benjamin DI, Kuo T, Lee RA, Li ML, Mar DJ, Costello DE, Nomura DK, Wang JC. The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. Science Signaling. 10. PMID 28743803 DOI: 10.1126/scisignal.aai7905  1
2017 Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Developmental Cell. 42: 9-21.e5. PMID 28697336 DOI: 10.1016/j.devcel.2017.06.003  1
2017 Ward CC, Kleinman JI, Nomura DK. NHS-Esters as Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots. Acs Chemical Biology. PMID 28445029 DOI: 10.1021/acschembio.7b00125  0.84
2017 Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/science.aag1417  1
2017 Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. PMID 28314591 DOI: 10.1016/j.immuni.2017.02.018  1
2017 Roberts LS, Yan P, Bateman LA, Nomura DK. Mapping Novel Metabolic Nodes Targeted by Anti-Cancer Drugs that Impair Triple-Negative Breast Cancer Pathogenicity. Acs Chemical Biology. PMID 28248089 DOI: 10.1021/acschembio.6b01159  1
2017 Bateman LA, Ku WM, Heslin MJ, Contreras CM, Skibola CF, Nomura DK. ASS1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity. Acs Chemical Biology. PMID 28229591 DOI: 10.1021/acschembio.6b01158  1
2017 Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A. MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. Embo Reports. PMID 28219903 DOI: 10.15252/embr.201643068  1
2017 Roberts AM, Miyamoto DK, Huffman TR, Bateman LA, Ives AN, Heslin MJ, Akopian D, Contreras CM, Rape M, Skibola CF, Nomura DK. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 as a Novel Pancreatic Cancer Target. Acs Chemical Biology. PMID 28186401 DOI: 10.1021/acschembio.7b00020  1
2017 Ford B, Bateman LA, Gutierrez-Palominos L, Park R, Nomura DK. Mapping Proteome-wide Targets of Glyphosate in Mice. Cell Chemical Biology. PMID 28132892 DOI: 10.1016/j.chembiol.2016.12.013  1
2017 Ruby MA, Massart J, Hunerdosse DM, Schönke M, Correia JC, Louie SM, Ruas JL, Näslund E, Nomura DK, Zierath JR. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Reports. 18: 636-646. PMID 28099843 DOI: 10.1016/j.celrep.2016.12.070  1
2017 Counihan JL, Duckering M, Dalvie E, Ku WM, Bateman LA, Fisher KJ, Nomura DK. Chemoproteomic profiling of acetanilide herbicides reveals their role in inhibiting fatty acid oxidation. Acs Chemical Biology. PMID 28094496 DOI: 10.1021/acschembio.6b01001  1
2016 To M, Peterson CW, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA. Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation. Molecular Biology of the Cell. PMID 27881664 DOI: 10.1091/mbc.E16-07-0483  1
2016 Kim HE, Grant AR, Simic MS, Kohnz RA, Nomura DK, Durieux J, Riera CE, Sanchez M, Kapernick E, Wolff S, Dillin A. Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. Cell. 166: 1539-1552.e16. PMID 27610574 DOI: 10.1016/j.cell.2016.08.027  1
2016 Roberts AM, Ward CC, Nomura DK. Activity-based protein profiling for mapping and pharmacologically interrogating proteome-wide ligandable hotspots. Current Opinion in Biotechnology. 43: 25-33. PMID 27568596 DOI: 10.1016/j.copbio.2016.08.003  1
2016 Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK. Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity. Acs Chemical Biology. PMID 27380425 DOI: 10.1021/acschembio.6b00433  1
2016 Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. PMID 27374330 DOI: 10.1016/j.cell.2016.05.071  1
2016 Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate JH. Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose. Plos One. 11: e0158111. PMID 27336308 DOI: 10.1371/journal.pone.0158111  1
2016 Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK. GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity. Cell Chemical Biology. PMID 27185638 DOI: 10.1016/j.chembiol.2016.03.017  1
2016 Nomura DK, Casida JE. Lipases and Their Inhibitors in Health and Disease. Chemico-Biological Interactions. PMID 27067293 DOI: 10.1016/j.cbi.2016.04.004  1
2016 Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola CF. The potential relevance of the endocannabinoid, 2-arachidonoylglycerol, in diffuse large B-cell lymphoma. Oncoscience. 3: 31-41. PMID 26973858  1
2016 Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nature Medicine. PMID 26950360 DOI: 10.1038/nm.4055  1
2016 Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, ... ... Nomura DK, et al. Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism. Cell Metabolism. PMID 26924217 DOI: 10.1016/j.cmet.2016.01.019  1
2016 Zhang J, Medina-Cleghorn D, Bernal-Mizrachi L, Bracci PM, Hubbard A, Conde L, Riby J, Nomura DK, Skibola CF. The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma Oncoscience. 3: 31-41. DOI: 10.18632/oncoscience.289  1
2015 Saghatelian A, Nomura DK, Weerapena E. Editorial overview: Omics: The maturation of chemical biology. Current Opinion in Chemical Biology. PMID 26739665 DOI: 10.1016/j.cbpa.2015.12.005  1
2015 Counihan JL, Ford B, Nomura DK. Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms. Current Opinion in Chemical Biology. 30: 68-76. PMID 26647369 DOI: 10.1016/j.cbpa.2015.11.007  1
2015 Medina-Cleghorn D, Bateman LA, Ford B, Heslin A, Fisher KJ, Dalvie ED, Nomura DK. Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms. Chemistry & Biology. 22: 1394-405. PMID 26496688 DOI: 10.1016/j.chembiol.2015.09.008  1
2015 Piano V, Benjamin DI, Valente S, Nenci S, Marrocco B, Mai A, Aliverti A, Nomura DK, Mattevi A. Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents. Acs Chemical Biology. 10: 2589-97. PMID 26322624 DOI: 10.1021/acschembio.5b00466  1
2015 Queiroz A, Medina-Cleghorn D, Marjanovic O, Nomura DK, Riley LW. Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strains. Pathogens and Disease. 73: ftv066. PMID 26319139 DOI: 10.1093/femspd/ftv066  1
2015 Sanchez-Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura DK, Cravatt BF, Conti B. Monoacylglycerol Lipase Regulates Fever Response. Plos One. 10: e0134437. PMID 26287872 DOI: 10.1371/journal.pone.0134437  1
2015 Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK. Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer. Acs Chemical Biology. 10: 1624-30. PMID 25945974 DOI: 10.1021/acschembio.5b00053  1
2015 Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK. Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells. Acs Chemical Biology. 10: 1616-23. PMID 25871544 DOI: 10.1021/acschembio.5b00240  1
2015 Rashidian J, Le Scolan E, Ji X, Zhu Q, Mulvihill MM, Nomura D, Luo K. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Science Signaling. 8: ra14. PMID 25670202 DOI: 10.1126/scisignal.2005735  1
2015 Anderson CM, Kazantzis M, Wang J, Venkatraman S, Goncalves RL, Quinlan CL, Ng R, Jastroch M, Benjamin DI, Nie B, Herber C, Van AA, Park MJ, Yun D, Chan K, ... ... Nomura DK, et al. Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake. Cell Reports. 10: 505-15. PMID 25620701 DOI: 10.1016/j.celrep.2014.12.048  1
2015 Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, ... Nomura DK, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/cb500893q  1
2014 Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Reports. 9: 2124-38. PMID 25497089 DOI: 10.1016/j.celrep.2014.11.018  1
2014 Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RA, Kleschevnikov AM. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. Plos One. 9: e114521. PMID 25474204 DOI: 10.1371/journal.pone.0114521  1
2014 Hunerdosse DM, Morris PJ, Miyamoto DK, Fisher KJ, Bateman LA, Ghazaleh JR, Zhong S, Nomura DK. Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target. Acs Chemical Biology. 9: 2905-13. PMID 25343321 DOI: 10.1021/cb500717g  1
2014 Medina-Cleghorn D, Nomura DK. Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms. Chemistry & Biology. 21: 1171-84. PMID 25237861 DOI: 10.1016/j.chembiol.2014.07.007  1
2014 Mulvihill MM, Benjamin DI, Ji X, Le Scolan E, Louie SM, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Chemistry & Biology. 21: 831-40. PMID 24954006 DOI: 10.1016/j.chembiol.2014.05.008  1
2014 Latimer LN, Lee ME, Medina-Cleghorn D, Kohnz RA, Nomura DK, Dueber JE. Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae. Metabolic Engineering. 25: 20-9. PMID 24930894 DOI: 10.1016/j.ymben.2014.06.002  1
2014 Mulvihill MM, Nomura DK. Metabolomic strategies to map functions of metabolic pathways. American Journal of Physiology. Endocrinology and Metabolism. 307: E237-44. PMID 24918200 DOI: 10.1152/ajpendo.00228.2014  1
2014 Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK. Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness. Acs Chemical Biology. 9: 1340-50. PMID 24738946 DOI: 10.1021/cb5001907  1
2014 Kohnz RA, Nomura DK. Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. Chemical Society Reviews. 43: 6859-69. PMID 24676249 DOI: 10.1039/c4cs00047a  1
2014 Morris PJ, Medina-Cleghorn D, Heslin A, King SM, Orr J, Mulvihill MM, Krauss RM, Nomura DK. Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia. Acs Chemical Biology. 9: 1097-103. PMID 24597639 DOI: 10.1021/cb500014r  1
2014 Hunerdosse D, Nomura DK. Activity-based proteomic and metabolomic approaches for understanding metabolism. Current Opinion in Biotechnology. 28: 116-26. PMID 24594637 DOI: 10.1016/j.copbio.2014.02.001  1
2014 Poole DP, Lee M, Tso P, Bunnett NW, Yo SJ, Lieu T, Shiu A, Wang JC, Nomura DK, Aponte GW. Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. American Journal of Physiology. Gastrointestinal and Liver Physiology. 306: G686-98. PMID 24578341 DOI: 10.1152/ajpgi.00433.2013  1
2014 Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nature Chemical Biology. 10: 113-21. PMID 24362705 DOI: 10.1038/nchembio.1429  1
2014 Medina-Cleghorn D, Heslin A, Morris PJ, Mulvihill MM, Nomura DK. Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides. Acs Chemical Biology. 9: 423-32. PMID 24205821 DOI: 10.1021/cb400796c  1
2013 Benjamin DI, Cozzo A, Ji X, Roberts LS, Louie SM, Mulvihill MM, Luo K, Nomura DK. Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity. Proceedings of the National Academy of Sciences of the United States of America. 110: 14912-7. PMID 23980144 DOI: 10.1073/pnas.1310894110  1
2013 Nomura DK, Cravatt BF. Lipid metabolism in cancer. Biochimica Et Biophysica Acta. 1831: 1497-8. PMID 23921253 DOI: 10.1016/j.bbalip.2013.08.001  1
2013 Louie SM, Roberts LS, Mulvihill MM, Luo K, Nomura DK. Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids. Biochimica Et Biophysica Acta. 1831: 1566-72. PMID 23872477 DOI: 10.1016/j.bbalip.2013.07.008  1
2013 Louie SM, Roberts LS, Nomura DK. Mechanisms linking obesity and cancer. Biochimica Et Biophysica Acta. 1831: 1499-508. PMID 23470257 DOI: 10.1016/j.bbalip.2013.02.008  1
2013 Medina-Cleghorn D, Nomura DK. Chemical approaches to study metabolic networks. PflüGers Archiv : European Journal of Physiology. 465: 427-40. PMID 23296751 DOI: 10.1007/s00424-012-1201-0  1
2013 Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdélyi K, Hao E, Holovac E, Haskó G, Cravatt BF, Nomura DK, Pacher P. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology. 144: 808-817.e15. PMID 23295443 DOI: 10.1053/j.gastro.2012.12.028  1
2013 Mulvihill MM, Nomura DK. Therapeutic potential of monoacylglycerol lipase inhibitors. Life Sciences. 92: 492-7. PMID 23142242 DOI: 10.1016/j.lfs.2012.10.025  1
2012 Morrison BE, Marcondes MC, Nomura DK, Sanchez-Alavez M, Sanchez-Gonzalez A, Saar I, Kim KS, Bartfai T, Maher P, Sugama S, Conti B. Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 189: 5498-502. PMID 23169588 DOI: 10.4049/jimmunol.1102150  1
2012 Benjamin DI, Cravatt BF, Nomura DK. Global profiling strategies for mapping dysregulated metabolic pathways in cancer. Cell Metabolism. 16: 565-77. PMID 23063552 DOI: 10.1016/j.cmet.2012.09.013  1
2012 Piro JR, Benjamin DI, Duerr JM, Pi Y, Gonzales C, Wood KM, Schwartz JW, Nomura DK, Samad TA. A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease. Cell Reports. 1: 617-23. PMID 22813736 DOI: 10.1016/j.celrep.2012.05.001  1
2011 Ruby MA, Nomura DK, Hudak CS, Barber A, Casida JE, Krauss RM. Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes. Plos One. 6: e26415. PMID 22073164 DOI: 10.1371/journal.pone.0026415  1
2011 Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (New York, N.Y.). 334: 809-13. PMID 22021672 DOI: 10.1126/science.1209200  1
2011 Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chemistry & Biology. 18: 846-56. PMID 21802006 DOI: 10.1016/j.chembiol.2011.05.009  1
2011 Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. The Journal of Pharmacology and Experimental Therapeutics. 339: 173-85. PMID 21719468 DOI: 10.1124/jpet.111.181370  1
2011 Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH. Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. The Journal of Pharmacology and Experimental Therapeutics. 338: 795-802. PMID 21659471 DOI: 10.1124/jpet.110.175778  1
2011 Chang JW, Nomura DK, Cravatt BF. A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chemistry & Biology. 18: 476-84. PMID 21513884 DOI: 10.1016/j.chembiol.2011.02.008  1
2011 Ahn K, Smith SE, Liimatta MB, Beidler D, Sadagopan N, Dudley DT, Young T, Wren P, Zhang Y, Swaney S, Van Becelaere K, Blankman JL, Nomura DK, Bhattachar SN, Stiff C, et al. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. 338: 114-24. PMID 21505060 DOI: 10.1124/jpet.111.180257  1
2011 Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/pnas.1015248108  1
2011 Nomura DK, Casida JE. Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain. Journal of Agricultural and Food Chemistry. 59: 2808-15. PMID 21341672 DOI: 10.1021/jf101747r  1
2011 Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu TR, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR. Design, synthesis, and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences of the United States of America. 108: 6715-20. PMID 21245351 DOI: 10.1073/pnas.1015258108  1
2010 Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology. 17: 831-40. PMID 20797612 DOI: 10.1016/j.chembiol.2010.06.009  1
2010 Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nature Neuroscience. 13: 1113-9. PMID 20729846 DOI: 10.1038/nn.2616  1
2010 Nomura DK, Dix MM, Cravatt BF. Activity-based protein profiling for biochemical pathway discovery in cancer. Nature Reviews. Cancer. 10: 630-8. PMID 20703252 DOI: 10.1038/nrc2901  1
2010 Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 140: 49-61. PMID 20079333 DOI: 10.1016/j.cell.2009.11.027  1
2009 Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 20270-5. PMID 19918051 DOI: 10.1073/pnas.0909411106  1
2009 Long JZ, Nomura DK, Cravatt BF. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chemistry & Biology. 16: 744-53. PMID 19635411 DOI: 10.1016/j.chembiol.2009.05.009  1
2008 Ruby MA, Nomura DK, Hudak CS, Mangravite LM, Chiu S, Casida JE, Krauss RM. Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 105: 14561-6. PMID 18794527 DOI: 10.1073/pnas.0807232105  1
2008 Nomura DK, Hudak CS, Ward AM, Burston JJ, Issa RS, Fisher KJ, Abood ME, Wiley JL, Lichtman AH, Casida JE. Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorganic & Medicinal Chemistry Letters. 18: 5875-8. PMID 18752948 DOI: 10.1016/j.bmcl.2008.08.007  1
2008 Casida JE, Nomura DK, Vose SC, Fujioka K. Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chemico-Biological Interactions. 175: 355-64. PMID 18495101 DOI: 10.1016/j.cbi.2008.04.008  1
2008 Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology. 4: 373-8. PMID 18438404 DOI: 10.1038/nchembio.86  1
2008 Nomura DK, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. Toxicology and Applied Pharmacology. 228: 42-8. PMID 18164358 DOI: 10.1016/j.taap.2007.11.021  1
2006 Nomura DK, Durkin KA, Chiang KP, Quistad GB, Cravatt BF, Casida JE. Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions. Chemical Research in Toxicology. 19: 1142-50. PMID 16978018 DOI: 10.1021/tx060117m  1
2006 Quistad GB, Liang SN, Fisher KJ, Nomura DK, Casida JE. Each lipase has a unique sensitivity profile for organophosphorus inhibitors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 91: 166-72. PMID 16449251 DOI: 10.1093/toxsci/kfj124  1
2005 Nomura DK, Leung D, Chiang KP, Quistad GB, Cravatt BF, Casida JE. A brain detoxifying enzyme for organophosphorus nerve poisons. Proceedings of the National Academy of Sciences of the United States of America. 102: 6195-200. PMID 15840715 DOI: 10.1073/pnas.0501915102  1
2003 Segall Y, Quistad GB, Nomura DK, Casida JE. Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 3301-3. PMID 12951114 DOI: 10.1016/S0960-894X(03)00721-2  1
2003 Segall Y, Quistad GB, Sparks SE, Nomura DK, Casida JE. Toxicological and structural features of organophosphorus and organosulfur cannabinoid CB1 receptor ligands. Toxicological Sciences : An Official Journal of the Society of Toxicology. 76: 131-7. PMID 12944586 DOI: 10.1093/toxsci/kfg216  1
2002 Quistad GB, Nomura DK, Sparks SE, Segall Y, Casida JE. Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides. Toxicology Letters. 135: 89-93. PMID 12243867 DOI: 10.1016/S0378-4274(02)00251-5  1
2002 Quistad GB, Sparks SE, Segall Y, Nomura DK, Casida JE. Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications. Toxicology and Applied Pharmacology. 179: 57-63. PMID 11884237 DOI: 10.1006/taap.2001.9342  1
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