Kimberly M. Lovell, Ph.D. - Related publications

Scripps Research Institute Florida 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Gopalakrishnan L, Chatterjee O, Ravishankar N, Suresh S, Raju R, Mahadevan A, Prasad TSK. Opioid receptors signaling network. Journal of Cell Communication and Signaling. PMID 34724150 DOI: 10.1007/s12079-021-00653-z   
2021 Mehr-Un-Nisa, Munawar MA, Rankin D, Hruby VJ, Porreca F, Lee YS. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509. PMID 34798381 DOI: 10.1016/j.bmc.2021.116509   
2021 Sharma KK, Cassell RJ, Meqbil YJ, Su H, Blaine AT, Cummins BR, Mores KL, Johnson DK, van Rijn RM, Altman RA. Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands. Rsc Medicinal Chemistry. 12: 1958-1967. PMID 34825191 DOI: 10.1039/d1md00025j   
2021 Yang Y, Wang Y, Zuo A, Li C, Wang W, Jiang W, Zhang X, Che X, Zhang Y, Wu W, Cen X, Wang H, Tian J. Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias. European Journal of Medicinal Chemistry. 113986. PMID 34802839 DOI: 10.1016/j.ejmech.2021.113986   
2021 Saini A, Patel R, Gaba S, Singh G, Gupta GD, Monga V. Adenosine receptor antagonists: Recent advances and therapeutic perspective. European Journal of Medicinal Chemistry. 227: 113907. PMID 34695776 DOI: 10.1016/j.ejmech.2021.113907   
2021 Liu S, Kang WJ, Abrimian A, Xu J, Cartegni L, Majumdar S, Hesketh P, Bekker A, Pan YX. Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, : Insight into Complex Mu Opioid Actions. Biomolecules. 11. PMID 34680158 DOI: 10.3390/biom11101525   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 34797051 DOI: 10.1021/acs.jmedchem.1c01327   
2021 Dodu JC, Moncayo RK, Damaj MI, Schlosburg JE, Akbarali HI, O'Brien LD, Kendall DA, Lu D, Lichtman AH. The CB Receptor Positive Allosteric Modulator, ZCZ011, Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 34625464 DOI: 10.1124/jpet.121.000723   
2021 Maciuszek M, Ortega-Gomez A, Maas SL, Garrido-Mesa J, Ferraro B, Perretti M, Merritt A, Nicolaes GAF, Soehnlein O, Chapman TM. Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists. European Journal of Medicinal Chemistry. 226: 113805. PMID 34536667 DOI: 10.1016/j.ejmech.2021.113805   
2021 Gao J, Yuan X, Zheng X, Zhao X, Wang T, Liang Q, Xiao C, Wang J, Li Q, Zhao X. Two-point immobilization of a conformation-specific beta-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomaterials Science. PMID 34704989 DOI: 10.1039/d1bm01222c   
2021 García M, Llorente V, Garriga L, Christmann U, Rodríguez-Escrich S, Virgili M, Fernández B, Bordas M, Ayet E, Burgueño J, Pujol M, Dordal A, Portillo-Salido E, Gris G, Vela JM, et al. Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ Receptor Antagonists for the Treatment of Pain. Journal of Medicinal Chemistry. 64: 10139-10154. PMID 34236190 DOI: 10.1021/acs.jmedchem.1c00417   
2021 Romantini N, Alam S, Dobitz S, Spillmann M, De Foresta M, Schibli R, Schertler GFX, Wennemers H, Deupi X, Behe M, Berger P. Exploring the signaling space of a GPCR using bivalent ligands with a rigid oligoproline backbone. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34810259 DOI: 10.1073/pnas.2108776118   
2021 Kai H, Horiguchi T, Kameyma T, Onodera N, Itoh N, Fujii Y, Ichihashi Y, Hirai K, Shintani T, Nakamura K, Minami K, Kasai E, Yoneda S, Murakami Y, Ogawa H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 52: 128384. PMID 34587541 DOI: 10.1016/j.bmcl.2021.128384   
2021 Faúndez-Parraguez M, Alarcón-Miranda C, Cho YH, Pessoa-Mahana H, Gallardo-Garrido C, Chung H, Faúndez M, Pessoa-Mahana D. New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists. International Journal of Molecular Sciences. 22. PMID 34681877 DOI: 10.3390/ijms222011212   
2021 Zamora JC, Smith HR, Jennings EM, Chavera TS, Kotipalli V, Jay A, Husbands SM, Disney A, Berg KA, Clarke WP. Long-term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox. Pharmacology Research & Perspectives. 9: e00887. PMID 34713624 DOI: 10.1002/prp2.887   
2021 Kong Q, Tian S, Ma C, Wang G, Zhang M. Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation. Neuroscience. PMID 34774714 DOI: 10.1016/j.neuroscience.2021.11.007   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Shinde AK, Badange RK, Reballi V, Achanta PK, Bojja K, Manchineella S, Rao Muddana N, Subramanian R, Choudary Palacharla R, Benade V, Jayarajan P, Thentu JB, Lingavarapu BB, Yarra S, Kagita N, et al. 1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H Receptor Inverse Agonist with Efficacy in Animal Models of Cognition. Chemmedchem. PMID 34761873 DOI: 10.1002/cmdc.202100583   
2021 Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro G. Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation. Acs Pharmacology & Translational Science. 4: 1483-1498. PMID 34661070 DOI: 10.1021/acsptsci.1c00019   
2021 Zhang F, Chen X, Chen J, Xu Y, Li S, Guo Y, Pu X. Probing Allosteric Regulation Mechanism of W7.35 on Agonist-Induced Activity for μOR by Mutation Simulation. Journal of Chemical Information and Modeling. PMID 34779608 DOI: 10.1021/acs.jcim.1c00650   
2021 Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190   
2021 Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. European Journal of Medicinal Chemistry. 226: 113878. PMID 34634742 DOI: 10.1016/j.ejmech.2021.113878   
2021 Avram S, Stan MS, Udrea AM, Buiu C, Boboc AA, Mernea M. 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds. Pharmaceutics. 13. PMID 34575524 DOI: 10.3390/pharmaceutics13091449   
2021 Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, et al. Structure, function and pharmacology of human itch GPCRs. Nature. PMID 34789874 DOI: 10.1038/s41586-021-04126-6   
2021 Luyao H, Luesch H, Uy M. GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge sp. Extends Its Therapeutic Potential for Noncommunicable Diseases. Molecules (Basel, Switzerland). 26. PMID 34577088 DOI: 10.3390/molecules26185618   
2021 Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. Similarities and differences upon binding of naturally occurring Δ-tetrahydrocannabinol-derivatives to cannabinoid CB and CB receptors. Pharmacological Research. 174: 105970. PMID 34758399 DOI: 10.1016/j.phrs.2021.105970   
2021 Brockett AT, Deng C, Shuster M, Perera S, DiMaggio D, Cheng M, Murkli S, Briken V, Roesch MR, Isaacs L. In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34613641 DOI: 10.1002/chem.202102919   
2021 Zarkin A, Jahan R, Uprety R, Zhang Y, McElhinny C, Snyder R, Gay E, Jewula G, Bool H, Clark SD, Runyon S. Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. Pharmaceuticals (Basel, Switzerland). 14. PMID 34681248 DOI: 10.3390/ph14101024   
2021 Pham N, Miller MD, Marty M. Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes. Chemical Research in Toxicology. 34: 2319-2330. PMID 34705446 DOI: 10.1021/acs.chemrestox.1c00205   
2021 Wu LX, Dong YP, Zhu QM, Zhang B, Ai BL, Yan T, Zhang GH, Sun L. Effects of dezocine on morphine tolerance and opioid receptor expression in a rat model of bone cancer pain. Bmc Cancer. 21: 1128. PMID 34670518 DOI: 10.1186/s12885-021-08850-0   
2021 Nozohouri S, Zhang Y, Albekairi TH, Vaidya B, Abbruscato TJ. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34663677 DOI: 10.1124/jpet.121.000831   
2021 DiCello JJ, Carbone SE, Saito A, Pham V, Szymaszkiewicz A, Gondin AB, Alvi S, Marique K, Shenoy P, Veldhuis NA, Fichna J, Canals M, Christopoulos A, Valant C, Poole DP. Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gut motility disorders. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 34755545 DOI: 10.1152/ajpgi.00297.2021   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC. Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. Acs Medicinal Chemistry Letters. 12: 1773-1782. PMID 34795867 DOI: 10.1021/acsmedchemlett.1c00388   
2021 Raj S, Lu L, Unsworth LD. Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells. Journal of Visualized Experiments : Jove. PMID 34806705 DOI: 10.3791/62448   
2021 Kulkarni SA, Krishnan SBB, Chandrasekhar B, Banerjee K, Sohn H, Madhavan T. Characterization of Phytochemicals in L. and Their Action Against Spike Glycoprotein Receptor-Binding Domain. Frontiers in Chemistry. 9: 735768. PMID 34650958 DOI: 10.3389/fchem.2021.735768   
2021 Wolf P, Mohr A, Gavins G, Behr V, Mörl K, Seitz O, Beck-Sickinger AG. Orthogonal Peptide-Templated Labeling Elucidates Lateral ET R/ET R Proximity and Reveals Altered Downstream Signaling. Chembiochem : a European Journal of Chemical Biology. PMID 34699123 DOI: 10.1002/cbic.202100340   
2021 Li W, Ding Z, Zhao Y, Jiang M, Zhang S, Zhao H, Lei K, Xu R, Zhao Y, Wang D, Chao M, Yin Y, Yang C, Wang L, Yan M. Novel Natural Inhibitors Targeting Enhancer of Zeste Homolog 2: A Comprehensive Structural Biology Research. Frontiers in Oncology. 11: 741403. PMID 34737956 DOI: 10.3389/fonc.2021.741403   
2021 Paredes-Ruiz KJ, Chavira-Ramos K, Orozco-Morales M, Karasu C, Tinkov AA, Aschner M, Santamaría A, Colín-González AL. On the Biomedical Properties of Endocannabinoid Degradation and Reuptake Inhibitors: Pre-clinical and Clinical Evidence. Neurotoxicity Research. PMID 34741755 DOI: 10.1007/s12640-021-00424-z   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Moustafa SR. The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio. Diabetology & Metabolic Syndrome. 13: 61. PMID 34099024 DOI: 10.1186/s13098-021-00677-w   
2021 Bender AM, Carter TR, Spock M, Rodriguez AL, Dickerson JW, Rook JM, Chang S, Qi A, Presley CC, Engers DW, Harp JM, Bridges TM, Niswender CM, Conn PJ, Lindsley CW. Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M Muscarinic Acetylcholine Receptor. Bioorganic & Medicinal Chemistry Letters. 128479. PMID 34838649 DOI: 10.1016/j.bmcl.2021.128479   
2021 Asai D, Inoue N, Sugiyama M, Fujita T, Matsuyama Y, Liu X, Matsushima A, Nose T, Costa T, Shimohigashi Y. Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation. Bioorganic & Medicinal Chemistry. 51: 116498. PMID 34794000 DOI: 10.1016/j.bmc.2021.116498   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Vázquez-Valadez VH, Hernández-Serda A, Jiménez-Cabiedes MF, Aguirre-Vidal P, González-Tapia I, Carreño-Vargas L, Alarcón-López YA, Espejel-Fuentes A, Martínez-Soriano P, Lugo Álvarez M, Velázquez-Sánchez AM, Markarian NM, Angeles E, Abrahamyan L. Evaluation of Inhibitory Activity In Silico of In-House Thiomorpholine Compounds between the ACE2 Receptor and S1 Subunit of SARS-CoV-2 Spike. Pathogens (Basel, Switzerland). 10. PMID 34578240 DOI: 10.3390/pathogens10091208   
2021 Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, et al. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland). 26. PMID 34576998 DOI: 10.3390/molecules26185527   
2021 Romero-Martínez BS, Montaño LM, Solís-Chagoyán H, Sommer B, Ramírez-Salinas GL, Pérez-Figueroa GE, Flores-Soto E. Possible Beneficial Actions of Caffeine in SARS-CoV-2. International Journal of Molecular Sciences. 22. PMID 34067243 DOI: 10.3390/ijms22115460   
2021 Nagarajan SK, Babu S, Devaraju P, Sohn H, Madhavan T. Structure and dynamics of the Somatostatin receptor 3 (SSTR3)-ligand binding in presence of lipids examined using computational structural biology methods. Proteins. PMID 34661304 DOI: 10.1002/prot.26267   
2021 Xu Q, Hu M, Li J, Ma X, Chu Z, Zhu Q, Zhang Y, Zhu P, Huang Y, He G. Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents. European Journal of Medicinal Chemistry. 227: 113876. PMID 34710748 DOI: 10.1016/j.ejmech.2021.113876