Ales Machara - Related publications

Affiliations: 
2009- Brock University, Saint Catharines, Ontario, Canada 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Thissera B, Sayed AM, Hassan MHA, Abdelwahab SF, Amaeze N, Semler VT, Alenezi FN, Yaseen M, Alhadrami HA, Belbahri L, Rateb ME. Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M Inhibitors from TDPEF34. Biomolecules. 11. PMID 34572579 DOI: 10.3390/biom11091366   
2021 Mishra A, Khan WH, Rathore AS. Synergistic Effects of Natural Compounds Toward Inhibition of SARS-CoV-2 3CL Protease. Journal of Chemical Information and Modeling. PMID 34694807 DOI: 10.1021/acs.jcim.1c00994   
2021 Legru A, Verdirosa F, Hernandez JF, Tassone G, Sannio F, Benvenuti M, Conde PA, Bossis G, Thomas CA, Crowder MW, Dillenberger M, Becker K, Pozzi C, Mangani S, Docquier JD, et al. 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity. European Journal of Medicinal Chemistry. 226: 113873. PMID 34626878 DOI: 10.1016/j.ejmech.2021.113873   
2021 Pokhrel S, Bouback TA, Samad A, Nur SM, Alam R, Abdullah-Al-Mamun M, Nain Z, Imon RR, Talukder MEK, Tareq MMI, Hossen MS, Karpiński TM, Ahammad F, Qadri I, Rahman MS. Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2. International Journal of Biological Macromolecules. PMID 34592225 DOI: 10.1016/j.ijbiomac.2021.09.146   
2021 Mancuso F, De Luca L, Bucolo F, Vrabel M, Angeli A, Capasso C, Supuran CT, Gitto R. 4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae. Chemmedchem. PMID 34592052 DOI: 10.1002/cmdc.202100510   
2021 Kneller DW, Li H, Galanie S, Phillips G, Labbé A, Weiss KL, Zhang Q, Arnould MA, Clyde A, Ma H, Ramanathan A, Jonsson CB, Head MS, Coates L, Louis JM, et al. Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease. Journal of Medicinal Chemistry. PMID 34705466 DOI: 10.1021/acs.jmedchem.1c01475   
2021 Li Y, Ouyang Y, Wu H, Wang P, Huang Y, Li X, Chen H, Sun Y, Hu X, Wang X, Li G, Lu Y, Li C, Lu X, Pang J, et al. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. European Journal of Medicinal Chemistry. 113979. PMID 34802838 DOI: 10.1016/j.ejmech.2021.113979   
2021 Ghosh AK, Shahabi D, Yadav M, Kovela S, Anson BJ, Lendy EK, Bonham C, Sirohi D, Brito-Sierra CA, Hattori SI, Kuhn R, Mitsuya H, Mesecar AD. Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26. PMID 34641337 DOI: 10.3390/molecules26195782   
2021 Rocha K, Magallon J, Reeves C, Phan K, Vu P, Oakley-Havens CL, Kwan S, Ramirez MS, LaVoi T, Donow H, Chapagain P, Santos R, Pinilla C, Giulianotti MA, Tolmasky ME. Inhibition of Aminoglycoside 6'--acetyltransferase Type Ib (AAC(6')-Ib): Structure-Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors. Biomedicines. 9. PMID 34572404 DOI: 10.3390/biomedicines9091218   
2021 Zhang TJ, Tu S, Zhang X, Wang QY, Hu SS, Zhang Y, Zhang ZH, Wang ZR, Meng FH. Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation. Bioorganic Chemistry. 117: 105417. PMID 34673452 DOI: 10.1016/j.bioorg.2021.105417   
2021 Zhang JH, Xie HX, Li Y, Wang KM, Song Z, Zhu KK, Fang L, Zhang J, Jiang CS. Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 128413. PMID 34634473 DOI: 10.1016/j.bmcl.2021.128413   
2021 Dobie C, Montgomery AP, Szabo R, Yu H, Skropeta D. Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors. Rsc Medicinal Chemistry. 12: 1680-1689. PMID 34778769 DOI: 10.1039/d1md00079a   
2021 Wang X, Duan W, Lin G, Li B, Chen M, Lei F. Synthesis, 3D-QSAR and Molecular Docking Study of Nopol-Based 1,2,4-Triazole-Thioether Compounds as Potential Antifungal Agents. Frontiers in Chemistry. 9: 757584. PMID 34765587 DOI: 10.3389/fchem.2021.757584   
2021 Anantharajan J, Baburajendran N, Lin G, Loh YY, Xu W, Huda Binte Ahmad N, Liu S, Jasson AE, Kuan JWL, Ng EY, Yeo YK, Hung AW, Joy J, Hill J, Ford HL, et al. Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Science : a Publication of the Protein Society. PMID 34761455 DOI: 10.1002/pro.4234   
2021 Weiss M, Loi EM, Sterle M, Balsollier C, Tomašič T, Pieters RJ, Gobec M, Anderluh M. New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth. Frontiers in Chemistry. 9: 666122. PMID 33937202 DOI: 10.3389/fchem.2021.666122   
2021 Quratulain -, Abbas Khan M, Ahmad I, Hamad A, Ashraf M, Hussain S. Synthesis, characterization, SAR, antioxidant, anti-acetylcholinesterase and anti-butyrylcholinesterase activities of cephradine Schiff bases. Pakistan Journal of Pharmaceutical Sciences. 34: 1989-1994. PMID 34836871   
2021 Kshirsagar RR, Gadekar PK, Khedkar VM, Vijayakumar V. Design, Synthesis, and the Effects of ()-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake. Acs Omega. 6: 24118-24127. PMID 34568690 DOI: 10.1021/acsomega.1c03600   
2021 Dar'in D, Kantin G, Chupakhin E, Sharoyko V, Krasavin M. Natural-Like Spirocyclic Δ -Butenolides Obtained from Diazo Homophthalimides. Chemistry (Weinheim An Der Bergstrasse, Germany). 27: 8221-8227. PMID 33848018 DOI: 10.1002/chem.202100880   
2021 Chen T, Li WQ, Liu Z, Jiang W, Liu T, Yang Q, Zhu XL, Yang GF. Discovery of Biphenyl-Sulfonamides as Novel β--Acetyl-d-Hexosaminidase Inhibitors via Structure-Based Virtual Screening. Journal of Agricultural and Food Chemistry. PMID 34587743 DOI: 10.1021/acs.jafc.1c01642   
2021 Duong TH, Nguyen HT, Nguyen CH, Tran NM, Danova A, Tran TM, Vu-Huynh KL, Musa V, Jutakanoke R, Nguyen NH, Sichaem J. Identification of Highly Potent α-Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies. Chemistry & Biodiversity. e2100499. PMID 34761862 DOI: 10.1002/cbdv.202100499   
2021 Campos-Almazán MI, Flores-Ramos M, Hernández-Campos A, Castillo R, Sierra-Campos E, Torgeson K, Peti W, Valdez-Solana M, Oria-Hernández J, Méndez ST, Castillo-Villanueva A, Jiménez-de Jesús H, Avitia-Domínguez C, Téllez-Valencia A. Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors. Bioorganic & Medicinal Chemistry. 48: 116418. PMID 34563877 DOI: 10.1016/j.bmc.2021.116418   
2021 Wang Y, Zhai J, Yang D, Han N, Liu Z, Liu Z, Li S, Yin J. Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Based on Network Pharmacology Prediction. Oxidative Medicine and Cellular Longevity. 2021: 7807046. PMID 34707780 DOI: 10.1155/2021/7807046   
2021 An Y, Liu W, Xie H, Fan H, Han J, Sun B. Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors. European Journal of Medicinal Chemistry. 227: 113950. PMID 34731761 DOI: 10.1016/j.ejmech.2021.113950   
2021 Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher C. Druggable allosteric sites in β-propeller lectins. Angewandte Chemie (International Ed. in English). PMID 34713573 DOI: 10.1002/anie.202109339   
2021 Wang Y, Wang J, Wang S, Cao Z, Gu D, Wang Y, Tian J, Yang Y. An efficient method based on an inhibitor-enzyme complex to screen an active compound against lipase from . Food & Function. PMID 34617090 DOI: 10.1039/d1fo01542g   
2021 Sultan A, Ali R, Ishrat R, Ali S. Anti-HIV and anti-HCV small molecule protease inhibitors in-silico repurposing against SARS-CoV-2 M for the treatment of COVID-19. Journal of Biomolecular Structure & Dynamics. 1-15. PMID 34569411 DOI: 10.1080/07391102.2021.1979097   
2021 Azimi F, Azizian H, Najafi M, Khodarahmi G, Saghaei L, Hassanzadeh M, Ghasemi JB, Faramarzi MA, Larijani B, Hassanzadeh F, Mahdavi M. Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor. Scientific Reports. 11: 20776. PMID 34675367 DOI: 10.1038/s41598-021-99899-1   
2021 Low YS, Garcia MD, Lonhienne T, Fraser JA, Schenk G, Guddat LW. Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports. 11: 21055. PMID 34702838 DOI: 10.1038/s41598-021-00349-9   
2021 Wang Z, Zang R, Niu Z, Wang W, Wang X, Tang Y. Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections. Bioorganic & Medicinal Chemistry Letters. 128405. PMID 34624489 DOI: 10.1016/j.bmcl.2021.128405   
2021 Yang L, Zhang D, Li JB, Zhang X, Zhou N, Zhang WY, Lu H. Prenylated xanthones with α-glucosidase and α-amylase inhibitory effects from the pericarp of . Journal of Asian Natural Products Research. 1-10. PMID 34762536 DOI: 10.1080/10286020.2021.1967328   
2021 Mirgany TO, Abdalla AN, Arifuzzaman M, Motiur Rahman AFM, Al-Salem HS. Quinazolin-4(3)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 2055-2067. PMID 34551654 DOI: 10.1080/14756366.2021.1972992   
2021 Fu W, Hu X, Yuan Q, Sun X, Xu Z, Zhang Y, Cheng J, Ye Y, Li Z, Shao X. Azo-incorporating Increases Inhibitory Activity of Succinate Dehydrogenase. Journal of Agricultural and Food Chemistry. PMID 34748325 DOI: 10.1021/acs.jafc.1c05551   
2021 Zhang B, Duan Y, Yang Y, Mao Q, Lin F, Gao J, Dai X, Zhang P, Li Q, Li J, Dai R, Wang S. Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors. European Journal of Medicinal Chemistry. 227: 113928. PMID 34688012 DOI: 10.1016/j.ejmech.2021.113928   
2021 Li Y, Zhang JH, Xie HX, Ge YX, Wang KM, Song ZL, Zhu KK, Zhang J, Jiang CS. Discovery of new 2-phenyl-1H-benzo[d]imidazole core-based potent α-glucosidase inhibitors: Synthesis, kinetic study, molecular docking, and in vivo anti-hyperglycemic evaluation. Bioorganic Chemistry. 117: 105423. PMID 34717239 DOI: 10.1016/j.bioorg.2021.105423   
2021 Jain S, Talley DC, Baljinnyam B, Choe J, Hanson Q, Zhu W, Xu M, Chen CZ, Zheng W, Hu X, Shen M, Rai G, Hall MD, Simeonov A, Zakharov AV. Hybrid Approach Reveals Novel Inhibitors of Multiple SARS-CoV-2 Variants. Acs Pharmacology & Translational Science. 4: 1675-1688. PMID 34608449 DOI: 10.1021/acsptsci.1c00176   
2021 Zhang JS, Hu Y, Song KS, Wu F, Zhu K, Xu DF, Zhang H. Diterpenoid glucosides with cystathionine γ-lyase inhibitory activity from Tinospora sinensis. Bioorganic Chemistry. 116: 105400. PMID 34627118 DOI: 10.1016/j.bioorg.2021.105400   
2021 Zhang L, Feng XZ, Xiao ZQ, Fan GR, Chen SX, Liao SL, Luo H, Wang ZD. Design, Synthesis, Antibacterial, Antifungal and Anticancer Evaluations of Novel -Pinene Quaternary Ammonium Salts. International Journal of Molecular Sciences. 22. PMID 34681957 DOI: 10.3390/ijms222011299   
2021 Chen YJ, Ma KY, Du SS, Zhang ZJ, Wu TL, Sun Y, Liu YQ, Yin XD, Zhou R, Yan YF, Wang RX, He YH, Chu QR, Tang C. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids. Journal of Agricultural and Food Chemistry. PMID 34623798 DOI: 10.1021/acs.jafc.1c05677   
2021 Kim W, Lee SM, Jeong PH, Jung JH, Kim YC. Synthesis and Structure-activity Relationship Studies of 1,5-Isomers of Triazole-pyrrolopyrimidine as Selective Janus Kinase 1 (JAK1) Inhibitors. Bioorganic & Medicinal Chemistry Letters. 128451. PMID 34774741 DOI: 10.1016/j.bmcl.2021.128451   
2021 Cheng X, Ma L. Enzymatic synthesis of fluorinated compounds. Applied Microbiology and Biotechnology. PMID 34625820 DOI: 10.1007/s00253-021-11608-0   
2021 Zhao B, Hu L, Song Y, Patil K, Ramani S, Atmar RL, Estes MK, Prasad BVV. Norovirus Protease Structure and Antivirals Development. Viruses. 13. PMID 34696498 DOI: 10.3390/v13102069   
2021 Ma QG, Tang Y, Sang ZP, Dong JH, Wei RR. Structurally diverse biflavonoids from the fruits of Citrus medica L. var. sarcodactylis Swingle and their hypolipidemic and immunosuppressive activities. Bioorganic Chemistry. 117: 105450. PMID 34710667 DOI: 10.1016/j.bioorg.2021.105450   
2021 Qiao Y, Qin Y, Liu L, Chen X, Li Y, Li Q. An Investigation into the Interaction between Double Hydroxide-Based Antioxidant Benzophenone Derivatives and Cyclooxygenase 2. Molecules (Basel, Switzerland). 26. PMID 34771031 DOI: 10.3390/molecules26216622   
2021 Dissanayake AA, Mills GL, Bonito G, Rennick B, Nair MG. Chemical Composition and Anti-Inflammatory and Antioxidant Activities of Extracts from Cultivated Morel Mushrooms, Species of Genus Morchella (Ascomycota). International Journal of Medicinal Mushrooms. 23: 73-83. PMID 34591400 DOI: 10.1615/IntJMedMushrooms.2021039297   
2021 Sangster JJ, Marshall JR, Turner NJ, Mangas-Sanchez J. New trends and future opportunities in the enzymatic formation of C-C, C-N, and C-O bonds. Chembiochem : a European Journal of Chemical Biology. PMID 34726813 DOI: 10.1002/cbic.202100464   
2021 Nadeem MS, Khan JA, Rashid U. Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. International Journal of Biological Macromolecules. PMID 34687762 DOI: 10.1016/j.ijbiomac.2021.10.102   
2021 Hong Y, Liao X, Chen Z. Screening and characterization of potential α-glucosidase inhibitors from Cercis chinensis Bunge fruits using ultrafiltration coupled with HPLC-ESI-MS/MS. Food Chemistry. 372: 131316. PMID 34653778 DOI: 10.1016/j.foodchem.2021.131316   
2021 Valenzuela-Chavira I, Corona-Martinez DO, Garcia-Orozco KD, Beltran-Torres M, Sanchez-Lopez F, Arvizu-Flores AA, Sugich-Miranda R, Lopez-Zavala AA, Robles-Zepeda RE, Islas-Osuna MA, Ochoa-Leyva A, Toney MD, Serrano-Posada H, Sotelo-Mundo RR. A Novel Glutathione -Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS Shrimp Pathogen. Toxins. 13. PMID 34564668 DOI: 10.3390/toxins13090664   
2021 Česnek M, Šafránek M, Dračínský M, Tloušťová E, Mertlíková-Kaiserová H, Hayes MP, Watts VJ, Janeba Z. Halogen Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases. Chemmedchem. PMID 34636150 DOI: 10.1002/cmdc.202100568   
2021 Moons SJ, Rossing E, Heming JJA, Janssen MACH, van Scherpenzeel M, Lefeber DJ, de Jonge MI, Langereis JD, Boltje TJ. Structure-Activity Relationship of Fluorinated Sialic Acid Inhibitors for Bacterial Sialylation. Bioconjugate Chemistry. 32: 1047-1051. PMID 34043338 DOI: 10.1021/acs.bioconjchem.1c00194