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Pascal Mercier, Ph.D. - Publications

Affiliations: 
2003 University of Alberta, Edmonton, Alberta, Canada 
Area:
structure, dynamics and function of proteins
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li MX, Mercier P, Hartman JJ, Sykes BD. Structural Basis of Activation of Fast Skeletal Muscle. Journal of Medicinal Chemistry. PMID 33703886 DOI: 10.1021/acs.jmedchem.0c01412  0.512
2021 Wang Y, Tadayon R, Santamaria L, Mercier P, Forristal CJ, Shaw GS. Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner. The Biochemical Journal. 478: 197-215. PMID 33449082 DOI: 10.1042/BCJ20200773  0.444
2020 Fu ZL, Mercier P, Eskandari-Sedighi G, Yang J, Westaway D, Sykes BD. Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction. Metabolomics : Official Journal of the Metabolomic Society. 16: 72. PMID 32533504 DOI: 10.1007/S11306-020-01690-2  0.424
2018 Cassiède M, Mercier P, Shipley PR, Dueck M, Kamravaei S, Nair S, Mino J, Pei L, Broadhurst D, Lacy P, Quémerais B. Comparison of computational approaches for identification and quantification of urinary metabolites in 1H NMR spectra Analytical Methods. 10: 2129-2137. DOI: 10.1039/C8Ay00830B  0.325
2016 Aguirre JD, Dunkerley KM, Mercier P, Shaw GS. Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28007983 DOI: 10.1073/Pnas.1613040114  0.512
2016 Aguirre JD, Dunkerley KM, Mercier P, Shaw GS. Solution structure of Serine 65 phosphorylated UBL domain from parkin Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb5Tr5/Pdb  0.356
2015 Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. The Embo Journal. 34: 2506-21. PMID 26254304 DOI: 10.15252/Embj.201592337  0.512
2014 Baryshnikova O, Robertson I, Mercier P, Sykes B. NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Mlf/Pdb  0.551
2014 Spratt DE, Mercier P, Pan Z, Shaw GS. Structure and Mechanism of the E3 Ligase Rbx1 in Complex with the E2 Enzyme CDC34 Charged with Ubiquitin Biophysical Journal. 106: 47a. DOI: 10.1016/J.Bpj.2013.11.342  0.507
2014 Glaves JP, Li MX, Mercier P, Fahlman RP, Sykes BD. High-throughput, multi-platform metabolomics on very small volumes: 1H NMR metabolite identification in an unadulterated tube-in-tube system Metabolomics. DOI: 10.1007/S11306-014-0678-2  0.457
2013 Bai JJ, Safadi SS, Mercier P, Barber KR, Shaw GS. Ataxin-3 is a multivalent ligand for the parkin Ubl domain. Biochemistry. 52: 7369-76. PMID 24063750 DOI: 10.1021/Bi400780V  0.533
2013 Spratt DE, Mercier P, Shaw GS. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. Plos One. 8: e74047. PMID 24058416 DOI: 10.1371/Journal.Pone.0074047  0.494
2013 Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS. A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nature Communications. 4: 1983. PMID 23770917 DOI: 10.1038/Ncomms2983  0.494
2013 Mercier P, Spratt D, Shaw G. Solution Structure of the Catalytic Domain of HHARI Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2M9Y/Pdb  0.503
2012 Julien O, Allen CN, Mercier P, Ramos CH, Blumenschein TM, Sykes BD. Dynamics of a Troponin Chimera Reproduce the Effects of Calcium on the Troponin Complex Biophysical Journal. 102: 230a. DOI: 10.1016/J.Bpj.2011.11.1262  0.729
2011 Julien O, Mercier P, Allen CN, Fisette O, Ramos CH, Lagüe P, Blumenschein TM, Sykes BD. Is there nascent structure in the intrinsically disordered region of troponin I? Proteins. 79: 1240-50. PMID 21322033 DOI: 10.1002/Prot.22959  0.751
2010 Julien O, Mercier P, Allen CN, Fisette O, Ramos CH, Lagüe P, Blumenschein TM, Sykes BD. Dynamics of a Skeletal Troponin C - Troponin I Chimera Probed by Comparison of Experimental and Simulated NMR Relaxation Parameters Biophysical Journal. 98: 652a. DOI: 10.1016/J.Bpj.2009.12.3575  0.756
2009 Julien O, Mercier P, Crane ML, Sykes BD. The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C. Protein Science : a Publication of the Protein Society. 18: 1165-74. PMID 19472326 DOI: 10.1002/Pro.121  0.624
2008 Baryshnikova OK, Robertson IM, Mercier P, Sykes BD. The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I. Biochemistry. 47: 10950-60. PMID 18803402 DOI: 10.1021/Bi801165C  0.587
2008 Julien O, Mercier P, Spyracopoulos L, Corrie JE, Sykes BD. NMR studies of the dynamics of a bifunctional rhodamine probe attached to troponin C. Journal of the American Chemical Society. 130: 2602-9. PMID 18251471 DOI: 10.1021/Ja0772694  0.543
2008 Wang X, Mercier P, Letourneau P, Sykes B. Solution structure of F104W cardiac troponin C Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15385  0.506
2007 Mercier P, Lewis MJ, Hau DD, Saltibus LF, Xiao W, Spyracopoulos L. Structure, interactions, and dynamics of the RING domain from human TRAF6. Protein Science : a Publication of the Protein Society. 16: 602-14. PMID 17327397 DOI: 10.1110/Ps.062358007  0.439
2007 Wang X, Mercier P, Letourneau P, Sykes B. Backbone and side chain chemical shift assignments of the F153-to-5-flurotryptophan mutant of human cardiac troponin C Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15400  0.487
2007 Mercier P, Lewis M, Hau D, Saltibus L, Xiao W, Spyracopoulos L. 1H, 13C, 15N chemical shift assignments for the human E2 ubiquitin conjugating enzyme Ubc13 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15092  0.316
2007 Mercier P, Lewis M, Hau D, Saltibus L, Xiao W, Spyracopoulos L. Solution structure of the RING domain from human TRAF6. Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15014  0.349
2006 Weljie AM, Newton J, Mercier P, Carlson E, Slupsky CM. Targeted profiling: quantitative analysis of 1H NMR metabolomics data. Analytical Chemistry. 78: 4430-42. PMID 16808451 DOI: 10.1021/Ac060209G  0.308
2005 Wang X, Mercier P, Letourneau PJ, Sykes BD. Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies. Protein Science : a Publication of the Protein Society. 14: 2447-60. PMID 16131667 DOI: 10.1110/Ps.051595805  0.524
2004 Lindhout DA, Litowski JR, Mercier P, Hodges RS, Sykes BD. NMR solution structure of a highly stable de novo heterodimeric coiled-coil. Biopolymers. 75: 367-75. PMID 15457434 DOI: 10.1002/Bip.20150  0.529
2004 Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC. Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives. Biochemistry. 43: 3385-95. PMID 15035610 DOI: 10.1021/Bi0359527  0.32
2003 Ferguson RE, Sun YB, Mercier P, Brack AS, Sykes BD, Corrie JE, Trentham DR, Irving M. In situ orientations of protein domains: troponin C in skeletal muscle fibers. Molecular Cell. 11: 865-74. PMID 12718873 DOI: 10.1016/S1097-2765(03)00096-0  0.572
2003 Kawulka K, Sprules T, McKay RT, Mercier P, Diaper CM, Zuber P, Vederas JC. Structure of subtilosin A, an antimicrobial peptide from Bacillus subtilis with unusual posttranslational modifications linking cysteine sulfurs to alpha-carbons of phenylalanine and threonine. Journal of the American Chemical Society. 125: 4726-7. PMID 12696888 DOI: 10.1021/Ja029654T  0.353
2003 Mercier P, Ferguson RE, Irving M, Corrie JE, Trentham DR, Sykes BD. NMR structure of a bifunctional rhodamine labeled N-domain of troponin C complexed with the regulatory "switch" peptide from troponin I: implications for in situ fluorescence studies in muscle fibers. Biochemistry. 42: 4333-48. PMID 12693929 DOI: 10.1021/Bi027041N  0.581
2003 Mercier P, Ferguson R, Irving M, Corrie J, Trentham D, Sykes B. The NMR Structure of a Bifunctional Rhodamine Labeled N-domain of Troponin C inComplex with the Regulatory 'Switch' Peptide from Troponin I Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5738  0.555
2001 Mercier P, Spyracopoulos L, Sykes BD. Structure, dynamics, and thermodynamics of the structural domain of troponin C in complex with the regulatory peptide 1-40 of troponin I. Biochemistry. 40: 10063-77. PMID 11513585 DOI: 10.1021/Bi010748+  0.618
2001 Mercier P, Spyracopoulos L, Sykes BD. Complex of the C-Domain of Troponin C with Residues 1-40 of Troponin I Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5071  0.55
2000 Mercier P, Li MX, Sykes BD. Role of the structural domain of troponin C in muscle regulation: NMR studies of Ca2+ binding and subsequent interactions with regions 1-40 and 96-115 of troponin I. Biochemistry. 39: 2902-11. PMID 10715110 DOI: 10.1021/Bi992579N  0.568
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