Megan L. McCain, Ph.D. - Publications

Affiliations: 
2012 Engineering and Applied Sciences Harvard University, Cambridge, MA, United States 
Area:
cardiac cell biology and tissue engineering, traumatic brain injury, and biological applications of micro- and nanotechnologies

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Petersen AP, Cho N, Lyra-Leite DM, Santoso JW, Gupta D, Ariyasinghe NR, McCain ML. Regulation of calcium dynamics and propagation velocity by tissue microstructure in engineered strands of cardiac tissue. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 32118279 DOI: 10.1093/intbio/zyaa003  1
2019 Yip JK, Harrison M, Villafuerte J, Fernandez GE, Petersen AP, Lien CL, McCain ML. Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab On a Chip. PMID 31872200 DOI: 10.1039/c9lc01044k  1
2019 Lyra-Leite DM, Andres AM, Cho N, Petersen AP, Ariyasinghe NR, Sarah Kim S, Gottlieb RA, McCain ML. Matrix-Guided Control of Mitochondrial Function in Cardiac Myocytes. Acta Biomaterialia. PMID 31401347 DOI: 10.1016/j.actbio.2019.08.007  1
2018 Petersen AP, Lyra-Leite DM, Ariyasinghe NR, Cho N, Goodwin CM, Kim JY, McCain ML. Microenvironmental Modulation of Calcium Wave Propagation Velocity in Engineered Cardiac Tissues. Cellular and Molecular Bioengineering. 11: 337-352. PMID 31719889 DOI: 10.1007/s12195-018-0522-2  1
2018 Ariyasinghe NR, Lyra-Leite DM, McCain ML. Engineering Cardiac Microphysiological Systems to Model Pathological Extracellular Matrix Remodeling. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29906229 DOI: 10.1152/ajpheart.00110.2018  1
2018 Cho N, Razipour SE, McCain ML. TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts. Experimental Biology and Medicine (Maywood, N.J.). 1535370218761628. PMID 29504479 DOI: 10.1177/1535370218761628  1
2017 Suh GC, Bettadapur A, Santoso JW, McCain ML. Fabrication of Micromolded Gelatin Hydrogels for Long-Term Culture of Aligned Skeletal Myotubes. Methods in Molecular Biology (Clifton, N.J.). 1668: 147-163. PMID 28842908 DOI: 10.1007/978-1-4939-7283-8_11  1
2017 Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML. Mitochondrial Function in Engineered Cardiac Tissues is Co-Regulated by Extracellular Matrix Elasticity and Tissue Alignment. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00290.2017. PMID 28733449 DOI: 10.1152/ajpheart.00290.2017  1
2017 Ariyasinghe NR, Reck CH, Viscio AA, Petersen AP, Lyra-Leite DM, Cho N, McCain ML. Engineering micromyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28726917 DOI: 10.1039/c7ib00081b  1
2017 Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Experimental Biology and Medicine (Maywood, N.J.). 1535370217701006. PMID 28343439 DOI: 10.1177/1535370217701006  1
2016 Bettadapur A, Suh GC, Geisse NA, Wang ER, Hua C, Huber HA, Viscio AA, Kim JY, Strickland JB, McCain ML. Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels. Scientific Reports. 6: 28855. PMID 27350122 DOI: 10.1038/srep28855  1
2016 Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK. Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. The Journal of Cell Biology. PMID 26858266 DOI: 10.1083/jcb.201508026  1
2016 Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK. Angiotensin II Induced Cardiac Dysfunction on a Chip. Plos One. 11: e0146415. PMID 26808388 DOI: 10.1371/journal.pone.0146415  1
2015 Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Experimental Biology and Medicine (Maywood, N.J.). PMID 25908635 DOI: 10.1177/1535370215583799  1
2015 Knight MB, Grosberg A, McCain ML. In vitro tools for quantifying structure-function relationships in cardiac myocyte cells and tissues Cardiac Cytoarchitecture: How to Maintain a Working Heart. 15-39. DOI: 10.1007/978-3-319-15263-9_2  1
2014 Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab On a Chip. 14: 3925-36. PMID 25093641 DOI: 10.1039/c4lc00688g  1
2014 Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20: 616-23. PMID 24813252 DOI: 10.1038/nm.3545  1
2014 McCain ML, Desplantez T, Kléber AG. Engineering cardiac cell junctions in vitro to study the intercalated disc. Cell Communication & Adhesion. 21: 181-91. PMID 24754499 DOI: 10.3109/15419061.2014.905931  1
2014 McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials. 35: 5462-71. PMID 24731714 DOI: 10.1016/j.biomaterials.2014.03.052  1
2014 McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1525-39. PMID 24682394 DOI: 10.1152/ajpheart.00799.2013  1
2013 Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. Advanced Functional Materials. 23: 3738-3746. PMID 26213529 DOI: 10.1002/adfm.201203319  1
2013 Agarwal A, Goss JA, Cho A, McCain ML, Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab On a Chip. 13: 3599-608. PMID 23807141 DOI: 10.1039/c3lc50350j  1
2013 McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proceedings of the National Academy of Sciences of the United States of America. 110: 9770-5. PMID 23716679 DOI: 10.1073/pnas.1304913110  1
2012 Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology. 30: 792-7. PMID 22820316 DOI: 10.1038/nbt.2269  1
2012 McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proceedings of the National Academy of Sciences of the United States of America. 109: 9881-6. PMID 22675119 DOI: 10.1073/pnas.1203007109  1
2012 Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. Journal of Pharmacological and Toxicological Methods. 65: 126-35. PMID 22521339 DOI: 10.1016/j.vascn.2012.04.001  1
2012 Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circulation Research. 110: 1445-53. PMID 22518032 DOI: 10.1161/CIRCRESAHA.111.259705  1
2012 Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovascular Research. 94: 58-65. PMID 22287588 DOI: 10.1093/cvr/cvs025  1
2012 McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. American Journal of Physiology. Heart and Circulatory Physiology. 302: H443-50. PMID 22081700 DOI: 10.1152/ajpheart.01218.2010  1
2012 Coan KE, Swann MJ, Ottl J. Binding moa by DPI Assay and Drug Development Technologies. 10: 405-406. DOI: 10.1089/adt.2012.1005.lr  1
2011 Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab On a Chip. 11: 4165-73. PMID 22072288 DOI: 10.1039/c1lc20557a  1
2011 McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. PflüGers Archiv : European Journal of Physiology. 462: 89-104. PMID 21499986 DOI: 10.1007/s00424-011-0951-4  1
2008 Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anatomical Record (Hoboken, N.J. : 2007). 291: 204-15. PMID 18085635 DOI: 10.1002/ar.20631  1
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