David J. Vocadlo, Ph.D. - Publications

Chemistry Simon Fraser University, Burnaby, British Columbia, Canada 
 2002 University of British Columbia, Vancouver, Vancouver, BC, Canada 
enzyme mechanisms, protein structure/function relationships, enzyme inhibitor design/synthesis and protein engineering

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Deen MC, Proceviat C, Shan X, Wu L, Shen DL, Davies GJ, Vocadlo DJ. Selective fluorogenic β-glucocerebrosidase substrates for convenient analysis of enzyme activity in cell and tissue homogenates. Acs Chemical Biology. PMID 32109051 DOI: 10.1021/acschembio.9b01044  0.68
2020 Vocadlo DJ, Alteen MG, Gros C, Meek R, Cardoso DA, Busmann J, Sangouard G, Deen MC, Tan HY, Shen DL, Russell CC, Davies GJ, Robinson PJ, McCluskey A. A direct fluorescent activity assay for glycosyltransferases enables convenient high-throughput screening: Application to O-GlcNAc Transferase. Angewandte Chemie (International Ed. in English). PMID 32092778 DOI: 10.1002/anie.202000621  0.68
2019 King DT, Males A, Davies GJ, Vocadlo DJ. Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes. Current Opinion in Chemical Biology. 53: 131-144. PMID 31654859 DOI: 10.1016/j.cbpa.2019.09.001  0.68
2019 Mangat CS, Vadlamani G, Holicek V, Chu M, Larmour V, Vocadlo DJ, Mulvey MR, Mark BL. Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam. Antimicrobial Agents and Chemotherapy. PMID 30782990 DOI: 10.1128/AAC.02112-18  0.68
2018 Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA. A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa. Chemical Communications (Cambridge, England). PMID 30178799 DOI: 10.1039/c8cc05281f  0.68
2017 Bouquet J, King DT, Vadlamani G, Benzie GR, Iorga B, Ide D, Adachi I, Kato A, Vocadlo DJ, Mark BL, Blériot Y, Désiré J. Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics. Organic & Biomolecular Chemistry. PMID 28513749 DOI: 10.1039/c7ob00838d  0.68
2017 Vadlamani G, Stubbs KA, Désiré J, Blériot Y, Vocadlo DJ, Mark BL. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Protein Science : a Publication of the Protein Society. PMID 28370529 DOI: 10.1002/pro.3166  0.68
2017 Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ. Structural and functional insight into human O-GlcNAcase. Nature Chemical Biology. PMID 28346405 DOI: 10.1038/nchembio.2358  0.68
2016 Cekic N, Heinonen JE, Stubbs KA, Roth C, He Y, Bennet AJ, McEachern EJ, Davies GJ, Vocadlo DJ. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcase. Chemical Science. 7: 3742-3750. PMID 29997861 DOI: 10.1039/c6sc00370b  0.68
2016 Perley-Robertson GE, Yadav AK, Winogrodzki JL, Stubbs KA, Mark BL, Vocadlo DJ. A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance. Acs Chemical Biology. PMID 27442597 DOI: 10.1021/acschembio.6b00552  0.68
2016 Noach I, Pluvinage B, Laurie C, Abe KT, Alteen MG, Vocadlo DJ, Boraston AB. The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from Clostridium perfringens. Journal of Molecular Biology. PMID 27038508 DOI: 10.1016/j.jmb.2016.03.020  1
2016 Hattie M, Cekic N, Debowski AW, Vocadlo DJ, Stubbs KA. Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-d-glucosaminidases. Organic & Biomolecular Chemistry. PMID 26924385 DOI: 10.1039/c6ob00297h  1
2015 Bergeron-Brlek M, Goodwin-Tindall J, Cekic N, Roth C, Zandberg WF, Shan X, Varghese V, Chan S, Davies GJ, Vocadlo DJ, Britton R. A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors. Angewandte Chemie (International Ed. in English). PMID 26545827 DOI: 10.1002/anie.201507985  1
2015 Gregg KJ, Suits MD, Deng L, Vocadlo DJ, Boraston AB. Structural analysis of a family 101 glycoside hydrolase in complex with carbohydrates reveals insights into its mechanism. The Journal of Biological Chemistry. PMID 26304114 DOI: 10.1074/jbc.M115.680470  1
2015 Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ. O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains. Nature Chemical Biology. 11: 319-25. PMID 25774941 DOI: 10.1038/nchembio.1774  1
2015 Kolappan S, Shen DL, Mosi R, Sun J, McEachern EJ, Vocadlo DJ, Craig L. Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallographica. Section D, Biological Crystallography. 71: 185-95. PMID 25664730 DOI: 10.1107/S1399004714024791  1
2015 Sodi VL, Khaku S, Krutilina R, Schwab LP, Vocadlo DJ, Seagroves TN, Reginato MJ. mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer. Molecular Cancer Research : McR. 13: 923-33. PMID 25636967 DOI: 10.1158/1541-7786.MCR-14-0536  1
2015 Yadav AK, Shen DL, Shan X, He X, Kermode AR, Vocadlo DJ. Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity. Journal of the American Chemical Society. 137: 1181-9. PMID 25562638 DOI: 10.1021/ja5106738  1
2015 Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ, Mark BL. The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide. The Journal of Biological Chemistry. 290: 2630-43. PMID 25480792 DOI: 10.1074/jbc.M114.618199  1
2014 Chakladar S, Wang Y, Clark T, Cheng L, Ko S, Vocadlo DJ, Bennet AJ. A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation. Nature Communications. 5: 5590. PMID 25475952 DOI: 10.1038/ncomms6590  1
2014 Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ. Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Molecular Neurodegeneration. 9: 42. PMID 25344697 DOI: 10.1186/1750-1326-9-42  1
2014 Zhu Y, Shan X, Yuzwa SA, Vocadlo DJ. The emerging link between O-GlcNAc and Alzheimer disease. The Journal of Biological Chemistry. 289: 34472-81. PMID 25336656 DOI: 10.1074/jbc.R114.601351  1
2014 Ferrer CM, Lynch TP, Sodi VL, Falcone JN, Schwab LP, Peacock DL, Vocadlo DJ, Seagroves TN, Reginato MJ. O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Molecular Cell. 54: 820-31. PMID 24857547 DOI: 10.1016/j.molcel.2014.04.026  1
2014 Yuzwa SA, Vocadlo DJ. O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond. Chemical Society Reviews. 43: 6839-58. PMID 24759912 DOI: 10.1039/c4cs00038b  1
2014 Yuzwa SA, Cheung AH, Okon M, McIntosh LP, Vocadlo DJ. O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers. Journal of Molecular Biology. 426: 1736-52. PMID 24444746 DOI: 10.1016/j.jmb.2014.01.004  1
2014 Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M, Mark BL. Conformational itinerary of Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle. The Journal of Biological Chemistry. 289: 4504-14. PMID 24362022 DOI: 10.1074/jbc.M113.521633  1
2014 Wang S, Shen DL, Lafont D, Vercoutter-Edouart AS, Mortuaire M, Shi Y, Maniti O, Girard-Egrot A, Lefebvre T, Pinto BM, Vocadlo D, Vidal S. Design of glycosyltransferase inhibitors targeting human O-GlcNAc transferase (OGT) Medchemcomm. 5: 1172-1178. DOI: 10.1039/c4md00063c  1
2013 Huang X, Vocadlo DJ. Reports from the award symposia hosted by the American Chemical Society, Division of Carbohydrate Chemistry at the 245th American Chemical Society National Meeting. Acs Chemical Biology. 8: 1361-5. PMID 24491206 DOI: 10.1021/cb400398f  1
2013 Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Blériot Y. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams. Chemical Communications (Cambridge, England). 49: 10983-5. PMID 24136176 DOI: 10.1039/c3cc46646a  1
2013 Pluvinage B, Stubbs KA, Hattie M, Vocadlo DJ, Boraston AB. Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH. Organic & Biomolecular Chemistry. 11: 7907-15. PMID 24132305 DOI: 10.1039/c3ob41579a  1
2013 Stubbs KA, Bacik JP, Perley-Robertson GE, Whitworth GE, Gloster TM, Vocadlo DJ, Mark BL. The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams. Chembiochem : a European Journal of Chemical Biology. 14: 1973-81. PMID 24009110 DOI: 10.1002/cbic.201300395  1
2013 Cecioni S, Vocadlo DJ. Tools for probing and perturbing O-GlcNAc in cells and in vivo. Current Opinion in Chemical Biology. 17: 719-28. PMID 23906602 DOI: 10.1016/j.cbpa.2013.06.030  1
2013 He X, Pierce O, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Qian Y, Brooks D, Kermode AR. Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds. Plant Biotechnology Journal. 11: 1034-43. PMID 23898885 DOI: 10.1111/pbi.12096  1
2013 Deng L, Tsybina P, Gregg KJ, Mosi R, Zandberg WF, Boraston AB, Vocadlo DJ. Synthesis of 4-methylumbelliferyl α-d-mannopyranosyl-(1→6)-β-d-mannopyranoside and development of a coupled fluorescent assay for GH125 exo-α-1,6-mannosidases. Bioorganic & Medicinal Chemistry. 21: 4839-45. PMID 23816041 DOI: 10.1016/j.bmc.2013.05.062  1
2013 Ma Z, Vocadlo DJ, Vosseller K. Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. The Journal of Biological Chemistry. 288: 15121-30. PMID 23592772 DOI: 10.1074/jbc.M113.470047  1
2012 Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL. Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chemistry & Biology. 19: 1471-82. PMID 23177201 DOI: 10.1016/j.chembiol.2012.09.016  1
2012 Vocadlo DJ, Withers SG. How to make a difference: mechanisms of protein and nucleic acid modifying enzymes. Current Opinion in Chemical Biology. 16: 461-4. PMID 23168221 DOI: 10.1016/j.cbpa.2012.10.033  1
2012 Vocadlo DJ. O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation. Current Opinion in Chemical Biology. 16: 488-97. PMID 23146438 DOI: 10.1016/j.cbpa.2012.10.021  1
2012 He X, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Gloster TM, Vocadlo DJ, Clarke LA, Qian Y, Kermode AR. Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease. Nature Communications. 3: 1062. PMID 22990858 DOI: 10.1038/ncomms2070  1
2012 Gloster TM, Vocadlo DJ. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. Nature Chemical Biology. 8: 683-94. PMID 22810773 DOI: 10.1038/nchembio.1029  1
2012 Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine. The Journal of Biological Chemistry. 287: 28898-916. PMID 22692203 DOI: 10.1074/jbc.M112.363499  1
2012 Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ. Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase. The Journal of Biological Chemistry. 287: 28882-97. PMID 22692202 DOI: 10.1074/jbc.M112.363721  1
2012 Yu Y, Zhang L, Li X, Run X, Liang Z, Li Y, Liu Y, Lee MH, Grundke-Iqbal I, Iqbal K, Vocadlo DJ, Liu F, Gong CX. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. Plos One. 7: e35277. PMID 22536363 DOI: 10.1371/journal.pone.0035277  1
2012 Shan X, Vocadlo DJ, Krieger C. Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis. Neuroscience Letters. 516: 296-301. PMID 22521585 DOI: 10.1016/j.neulet.2012.04.018  1
2012 Hehemann JH, Smyth L, Yadav A, Vocadlo DJ, Boraston AB. Analysis of keystone enzyme in Agar hydrolysis provides insight into the degradation (of a polysaccharide from) red seaweeds. The Journal of Biological Chemistry. 287: 13985-95. PMID 22393053 DOI: 10.1074/jbc.M112.345645  1
2012 Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature Chemical Biology. 8: 393-9. PMID 22366723 DOI: 10.1038/nchembio.797  1
2012 Shen DL, Gloster TM, Yuzwa SA, Vocadlo DJ. Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates. The Journal of Biological Chemistry. 287: 15395-408. PMID 22311971 DOI: 10.1074/jbc.M111.310664  1
2011 Mark BL, Vocadlo DJ, Oliver A. Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway. Future Microbiology. 6: 1415-27. PMID 22122439 DOI: 10.2217/fmb.11.128  1
2011 Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB. Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis. Structure (London, England : 1993). 19: 1603-14. PMID 22078560 DOI: 10.1016/j.str.2011.08.011  1
2011 Lee SS, Greig IR, Vocadlo DJ, McCarter JD, Patrick BO, Withers SG. Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides. Journal of the American Chemical Society. 133: 15826-9. PMID 21910446 DOI: 10.1021/ja204829r  1
2011 Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, Hehemann JH, Higgins MA, Deng L, Ogunniyi AD, Stroeher UH, El Warry N, Burke RD, Czjzek M, Paton JC, Vocadlo DJ, Boraston AB. The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure (London, England : 1993). 19: 640-51. PMID 21565699 DOI: 10.1016/j.str.2011.03.001  1
2011 Gregg KJ, Zandberg WF, Hehemann JH, Whitworth GE, Deng L, Vocadlo DJ, Boraston AB. Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans. The Journal of Biological Chemistry. 286: 15586-96. PMID 21388958 DOI: 10.1074/jbc.M111.223172  1
2011 Zamorano L, Reeve TM, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A. AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains. Antimicrobial Agents and Chemotherapy. 55: 1990-6. PMID 21357303 DOI: 10.1128/AAC.01688-10  1
2011 Bacik JP, Whitworth GE, Stubbs KA, Yadav AK, Martin DR, Bailey-Elkin BA, Vocadlo DJ, Mark BL. Molecular basis of 1,6-anhydro bond cleavage and phosphoryl transfer by Pseudomonas aeruginosa 1,6-anhydro-N-acetylmuramic acid kinase. The Journal of Biological Chemistry. 286: 12283-91. PMID 21288904 DOI: 10.1074/jbc.M110.198317  1
2011 Mayer A, Gloster TM, Chou WK, Vocadlo DJ, Tanner ME. 6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate. Bioorganic & Medicinal Chemistry Letters. 21: 1199-201. PMID 21273069 DOI: 10.1016/j.bmcl.2010.12.090  1
2011 Gloster TM, Zandberg WF, Heinonen JE, Shen DL, Deng L, Vocadlo DJ. Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells. Nature Chemical Biology. 7: 174-81. PMID 21258330 DOI: 10.1038/nchembio.520  1
2011 Yuzwa SA, Yadav AK, Skorobogatko Y, Clark T, Vosseller K, Vocadlo DJ. Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody. Amino Acids. 40: 857-68. PMID 20706749 DOI: 10.1007/s00726-010-0705-1  1
2010 Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ. Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chemistry & Biology. 17: 949-58. PMID 20851344 DOI: 10.1016/j.chembiol.2010.07.005  1
2010 Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ. Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chemistry & Biology. 17: 937-48. PMID 20851343 DOI: 10.1016/j.chembiol.2010.07.006  1
2010 Balcewich MD, Reeve TM, Orlikow EA, Donald LJ, Vocadlo DJ, Mark BL. Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase. Journal of Molecular Biology. 400: 998-1010. PMID 20594961 DOI: 10.1016/j.jmb.2010.05.040  1
2010 Zamorano L, Reeve TM, Deng L, Juan C, Moyá B, Cabot G, Vocadlo DJ, Mark BL, Oliver A. NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 54: 3557-63. PMID 20566764 DOI: 10.1128/AAC.00385-10  1
2010 Parsons TB, Patel MK, Boraston AB, Vocadlo DJ, Fairbanks AJ. Streptococcus pneumoniae endohexosaminidase D; feasibility of using N-glycan oxazoline donors for synthetic glycosylation of a GlcNAc-asparagine acceptor. Organic & Biomolecular Chemistry. 8: 1861-9. PMID 20449490 DOI: 10.1039/b926078a  1
2010 Gloster TM, Vocadlo DJ. Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes. Current Signal Transduction Therapy. 5: 74-91. PMID 20396401 DOI: 10.2174/157436210790226537  1
2010 He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ. Visualizing the reaction coordinate of an O-GlcNAc hydrolase. Journal of the American Chemical Society. 132: 1807-9. PMID 20067256 DOI: 10.1021/ja9086769  1
2010 Whitworth GE, Zandberg WF, Clark T, Vocadlo DJ. Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation. Glycobiology. 20: 287-99. PMID 19907056 DOI: 10.1093/glycob/cwp173  1
2010 Macauley MS, Vocadlo DJ. Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochimica Et Biophysica Acta. 1800: 107-21. PMID 19664691 DOI: 10.1016/j.bbagen.2009.07.028  1
2009 Yuzwa SA, Vocadlo DJ. O-GlcNAc modification and the tauopathies: insights from chemical biology. Current Alzheimer Research. 6: 451-4. PMID 19874270 DOI: 10.2174/156720509789207967  1
2009 Greig IR, Macauley MS, Williams IH, Vocadlo DJ. Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships. Journal of the American Chemical Society. 131: 13415-22. PMID 19715310 DOI: 10.1021/ja904506u  1
2009 Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM. Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proceedings of the National Academy of Sciences of the United States of America. 106: 13427-32. PMID 19666537 DOI: 10.1073/pnas.0904638106  1
2009 Higgins MA, Whitworth GE, El Warry N, Randriantsoa M, Samain E, Burke RD, Vocadlo DJ, Boraston AB. Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases. The Journal of Biological Chemistry. 284: 26161-73. PMID 19608744 DOI: 10.1074/jbc.M109.024067  1
2009 Balcewich MD, Stubbs KA, He Y, James TW, Davies GJ, Vocadlo DJ, Mark BL. Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Science : a Publication of the Protein Society. 18: 1541-51. PMID 19499593 DOI: 10.1002/pro.137  1
2009 Macauley MS, Vocadlo DJ. Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase. Carbohydrate Research. 344: 1079-84. PMID 19423084 DOI: 10.1016/j.carres.2009.04.017  1
2009 Shan X, Vocadlo D, Krieger C. Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS. Neuroscience Letters. 458: 70-4. PMID 19379791 DOI: 10.1016/j.neulet.2009.04.031  1
2009 Marcelo F, He Y, Yuzwa SA, Nieto L, Jiménez-Barbero J, Sollogoub M, Vocadlo DJ, Davies GD, Blériot Y. Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion. Journal of the American Chemical Society. 131: 5390-2. PMID 19331390 DOI: 10.1021/ja809776r  1
2009 Asgarali A, Stubbs KA, Oliver A, Vocadlo DJ, Mark BL. Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 53: 2274-82. PMID 19273679 DOI: 10.1128/AAC.01617-08  1
2009 Abbott DW, Macauley MS, Vocadlo DJ, Boraston AB. Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. The Journal of Biological Chemistry. 284: 11676-89. PMID 19181667 DOI: 10.1074/jbc.M809663200  1
2009 Stubbs KA, Macauley MS, Vocadlo DJ. A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angewandte Chemie (International Ed. in English). 48: 1300-3. PMID 19130519 DOI: 10.1002/anie.200804583  1
2009 Francisco H, Kollins K, Varghis N, Vocadlo D, Vosseller K, Gallo G. O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program. Developmental Neurobiology. 69: 162-73. PMID 19086029 DOI: 10.1002/dneu.20695  1
2009 Tallent MK, Varghis N, Skorobogatko Y, Hernandez-Cuebas L, Whelan K, Vocadlo DJ, Vosseller K. In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. The Journal of Biological Chemistry. 284: 174-81. PMID 19004831 DOI: 10.1074/jbc.M807431200  1
2009 Stubbs KA, Vocadlo DJ. Affinity-based proteomics probes; Tools for studying carbohydrate- processing enzymes Australian Journal of Chemistry. 62: 521-527. DOI: 10.1071/CH09140  1
2009 Davies GJ, Withers SG, Vocadlo DJ. The chitopentaose complex of a mutant en egg-white lysozyme displays no distortion of the -1 sugar away from a 4C1 chair conformation Australian Journal of Chemistry. 62: 528-532. DOI: 10.1071/CH09038  1
2008 Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ. Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. The Journal of Biological Chemistry. 283: 34687-95. PMID 18842583 DOI: 10.1074/jbc.M804525200  1
2008 Scaffidi A, Stubbs KA, Vocadlo DJ, Stick RV. The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc. Carbohydrate Research. 343: 2744-53. PMID 18804755 DOI: 10.1016/j.carres.2008.08.012  1
2008 Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature Chemical Biology. 4: 483-90. PMID 18587388 DOI: 10.1038/nchembio.96  1
2008 Vocadlo DJ, Davies GJ. Mechanistic insights into glycosidase chemistry. Current Opinion in Chemical Biology. 12: 539-55. PMID 18558099 DOI: 10.1016/j.cbpa.2008.05.010  1
2008 Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nature Structural & Molecular Biology. 15: 764-5. PMID 18536723 DOI: 10.1038/nsmb.1443  1
2008 Ficko-Blean E, Stubbs KA, Nemirovsky O, Vocadlo DJ, Boraston AB. Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB. Proceedings of the National Academy of Sciences of the United States of America. 105: 6560-5. PMID 18443291 DOI: 10.1073/pnas.0711491105  1
2008 Stubbs KA, Scaffidi A, Debowski AW, Mark BL, Stick RV, Vocadlo DJ. Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ. Journal of the American Chemical Society. 130: 327-35. PMID 18067297 DOI: 10.1021/ja0763605  1
2008 Vocadlo DJ, Withers SG. Glycosidase-catalysed oligosaccharide synthesis Carbohydrates in Chemistry and Biology. 2: 723-844. DOI: 10.1002/9783527618255.ch29  1
2007 Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo DJ, Stick RV. A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases. Organic & Biomolecular Chemistry. 5: 3013-9. PMID 17728868 DOI: 10.1039/b709681j  1
2007 Stubbs KA, Balcewich M, Mark BL, Vocadlo DJ. Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. The Journal of Biological Chemistry. 282: 21382-91. PMID 17439950 DOI: 10.1074/jbc.M700084200  1
2007 Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. Journal of the American Chemical Society. 129: 635-44. PMID 17227027 DOI: 10.1021/ja065697o  1
2006 Stubbs KA, Vocadlo DJ. Functional proteomic profiling of glycan-processing enzymes. Methods in Enzymology. 415: 253-68. PMID 17116479 DOI: 10.1016/S0076-6879(06)15016-8  1
2006 Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A. Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor. Chemical Communications (Cambridge, England). 4372-4. PMID 17057847 DOI: 10.1039/b612154c  1
2006 Sheldon WL, Macauley MS, Taylor EJ, Robinson CE, Charnock SJ, Davies GJ, Vocadlo DJ, Black GW. Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. The Biochemical Journal. 399: 241-7. PMID 16822234 DOI: 10.1042/BJ20060307  1
2006 Mayer C, Vocadlo DJ, Mah M, Rupitz K, Stoll D, Warren RA, Withers SG. Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi. The Febs Journal. 273: 2929-41. PMID 16762038 DOI: 10.1111/j.1742-4658.2006.05308.x  1
2006 Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nature Structural & Molecular Biology. 13: 365-71. PMID 16565725 DOI: 10.1038/nsmb1079  1
2006 CetinbaÅŸ N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ. Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry. 45: 3835-44. PMID 16533067 DOI: 10.1021/bi052370b  1
2006 Stubbs KA, Zhang N, Vocadlo DJ. A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase. Organic & Biomolecular Chemistry. 4: 839-45. PMID 16493467 DOI: 10.1039/b516273d  1
2006 Stubbs KA, Macauley MS, Vocadlo DJ. A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides. Carbohydrate Research. 341: 1764-9. PMID 16472788 DOI: 10.1016/j.carres.2005.12.009  1
2006 Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Molecular Cell. 21: 109-22. PMID 16387658 DOI: 10.1016/j.molcel.2005.10.034  1
2005 Macauley MS, Stubbs KA, Vocadlo DJ. O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. Journal of the American Chemical Society. 127: 17202-3. PMID 16332065 DOI: 10.1021/ja0567687  1
2005 Vocadlo DJ, Withers SG. Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases. Biochemistry. 44: 12809-18. PMID 16171396 DOI: 10.1021/bi051121k  1
2005 Macauley MS, Whitworth GE, Debowski AW, Chin D, Vocadlo DJ. O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. The Journal of Biological Chemistry. 280: 25313-22. PMID 15795231 DOI: 10.1074/jbc.M413819200  1
2005 Vocadlo DJ, Withers SG. The chemical synthesis of 2-deoxy-2-fluorodisaccharide probes of the hen egg white lysozyme mechanism. Carbohydrate Research. 340: 379-88. PMID 15680592 DOI: 10.1016/j.carres.2004.12.015  1
2004 Vocadlo DJ, Bertozzi CR. A strategy for functional proteomic analysis of glycosidase activity from cell lysates. Angewandte Chemie (International Ed. in English). 43: 5338-42. PMID 15468183 DOI: 10.1002/anie.200454235  1
2004 Yang JK, Yoon HJ, Ahn HJ, Lee BI, Pedelacq JD, Liong EC, Berendzen J, Laivenieks M, Vieille C, Zeikus GJ, Vocadlo DJ, Withers SG, Suh SW. Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase. Journal of Molecular Biology. 335: 155-65. PMID 14659747 DOI: 10.1016/j.jmb.2003.10.026  1
2003 Vocadlo DJ, Hang HC, Kim EJ, Hanover JA, Bertozzi CR. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 9116-21. PMID 12874386 DOI: 10.1073/pnas.1632821100  1
2002 Williams SJ, Mark BL, Vocadlo DJ, James MN, Withers SG. Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. The Journal of Biological Chemistry. 277: 40055-65. PMID 12171933 DOI: 10.1074/jbc.M206481200  1
2002 Vocadlo DJ, Wicki J, Rupitz K, Withers SG. A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant. Biochemistry. 41: 9736-46. PMID 12146939  1
2002 Vocadlo DJ, Wicki J, Rupitz K, Withers SG. Mechanism of Thermoanaerobacterium saccharolyticum beta-xylosidase: kinetic studies. Biochemistry. 41: 9727-35. PMID 12146938  1
2001 Mark BL, Vocadlo DJ, Zhao D, Knapp S, Withers SG, James MN. Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. The Journal of Biological Chemistry. 276: 42131-7. PMID 11522797 DOI: 10.1074/jbc.M107154200  1
2001 Vocadlo DJ, Davies GJ, Laine R, Withers SG. Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate. Nature. 412: 835-8. PMID 11518970 DOI: 10.1038/35090602  1
2001 Hou Y, Vocadlo DJ, Leung A, Withers SG, Mahuran D. Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B. Biochemistry. 40: 2201-9. PMID 11329289  1
2001 Mark BL, Vocadlo DJ, Knapp S, Triggs-Raine BL, Withers SG, James MN. Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. The Journal of Biological Chemistry. 276: 10330-7. PMID 11124970 DOI: 10.1074/jbc.M011067200  1
2000 Vocadlo DJ, Withers SG. Identification of active site residues in glycosidases by use of tandem mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 146: 203-22. PMID 10948504 DOI: 10.1385/1-59259-045-4:203  1
2000 Vocadlo DJ, Mayer C, He S, Withers SG. Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluoride. Biochemistry. 39: 117-26. PMID 10625486  1
1998 Vocadlo DJ, MacKenzie LF, He S, Zeikus GJ, Withers SG. Identification of glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum beta-xylosidase using electrospray MS. The Biochemical Journal. 335: 449-55. PMID 9761746  1
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