Susan L. Mercer, Ph.D. - Related publications

2008 Pharmaceutical Sciences University of Maryland School of Medicine, Baltimore, MD, United States 
Opioid synthesis
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Zhang M, Xu B, Li N, Zhang R, Zhang Q, Shi X, Xu K, Xiao J, Chen D, Niu J, Shi Y, Fang Q. Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of Medicinal Chemistry. PMID 34465090 DOI: 10.1021/acs.jmedchem.1c00694   
2021 Dodu JC, Moncayo RK, Damaj MI, Schlosburg JE, Akbarali HI, O'Brien LD, Kendall DA, Lu D, Lichtman AH. The CB Receptor Positive Allosteric Modulator, ZCZ011, Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 34625464 DOI: 10.1124/jpet.121.000723   
2021 Fan BW, Liu YL, Zhu GX, Wu B, Zhang MM, Deng Q, Wang JL, Chen JX, Han RW, Wei J. The active fragments of ghrelin cross the blood-brain barrier and enter the brain to produce antinociceptive effects after systemic administration. Canadian Journal of Physiology and Pharmacology. 1-12. PMID 34492212 DOI: 10.1139/cjpp-2020-0668   
2021 Degrandmaison J, Grisé O, Parent JL, Gendron L. Differential barcoding of opioid receptors trafficking. Journal of Neuroscience Research. PMID 34559903 DOI: 10.1002/jnr.24949   
2021 Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273   
2021 Aldrich JV, McLaughlin JP. Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. Handbook of Experimental Pharmacology. PMID 34463847 DOI: 10.1007/164_2021_519   
2021 Zamarripa CA, Pareek T, Schrock HM, Prisinzano TE, Blough BE, Sufka KJ, Freeman KB. The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats. Psychopharmacology. PMID 34430992 DOI: 10.1007/s00213-021-05965-x   
2021 Stahl EL, Bohn LM. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists. Biochemistry. PMID 34468132 DOI: 10.1021/acs.biochem.1c00466   
2021 Li T, Wang L, Zhang L, Li B, Wang D, Zhang L, Wang T, Fu F. Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system. European Journal of Pharmacology. 174443. PMID 34464604 DOI: 10.1016/j.ejphar.2021.174443   
2021 Duke AN, Tiruveedhula VVNPB, Sharmin D, Knutson DE, Cook JM, Platt DM, Rowlett JK. Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABA receptor subtypes. Drug and Alcohol Dependence. 228: 108985. PMID 34500240 DOI: 10.1016/j.drugalcdep.2021.108985   
2021 Gifford C, McGahan B, Miracle S, Minnema A, Murphy C, Vazquez D, Weaver T, Farhadi H. Perioperative Subcutaneous Methylnaltrexone Does Not Enhance Gastrointestinal Recovery after Posterior Short-Segment Spinal Arthrodesis Surgery: A Randomized Controlled Trial. The Spine Journal : Official Journal of the North American Spine Society. PMID 34419626 DOI: 10.1016/j.spinee.2021.08.004   
2021 Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2   
2021 Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. Rsc Chemical Biology. 2: 77-93. PMID 34458776 DOI: 10.1039/d0cb00165a   
2021 Bailey AMJ, Li HO, Burns K, Cheng W, Collister D, Westby EP, Purdy KS, Walsh M, Tennankore KK. Targeting the Opioid Pathway for the Treatment of Chronic Kidney Disease Associated Pruritus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The British Journal of Dermatology. PMID 34582571 DOI: 10.1111/bjd.20769   
2021 Hossain R, Al-Khafaji K, Khan RA, Sarkar C, Islam MS, Dey D, Jain D, Faria F, Akbor R, Atolani O, Oliveira SMR, Siyadatpanah A, Pereira ML, Islam MT. Quercetin and/or Ascorbic Acid Modulatory Effect on Phenobarbital-Induced Sleeping Mice Possibly through GABA and GABA Receptor Interaction Pathway. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451819 DOI: 10.3390/ph14080721   
2021 Gerak LR, France CP. Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys. Drug and Alcohol Dependence. 227: 108991. PMID 34482043 DOI: 10.1016/j.drugalcdep.2021.108991   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -mechanisms of action and adverse drug effects (part i). Postgraduate Medicine. PMID 34551662 DOI: 10.1080/00325481.2021.1982297   
2021 Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413   
2021 Cappoli N, Aceto P, Tabolacci E, Mezzogori D, Sollazzi L, Navarra P, Dello Russo C. Effects of remifentanil on human C20 microglial pro-inflammatory activation. European Review For Medical and Pharmacological Sciences. 25: 5268-5274. PMID 34486703 DOI: 10.26355/eurrev_202108_26547   
2021 Brockett AT, Deng C, Shuster M, Perera S, DiMaggio D, Cheng M, Murkli S, Briken V, Roesch MR, Isaacs L. In Vitro and In Vivo Sequestration of Methamphetamine by a Sulfated Acyclic CB[n]-Type Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34613641 DOI: 10.1002/chem.202102919   
2021 Zhao Y, Joshi AA, Aldrich JV, Murray TF. Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 143: 112173. PMID 34536757 DOI: 10.1016/j.biopha.2021.112173   
2021 Elvir-Lazo OL, White PF, Cruz Eng H, Yumul F, Chua R, Yumul R. Impact of chronic medications in the perioperative period -anesthetic implications (part ii). Postgraduate Medicine. PMID 34551658 DOI: 10.1080/00325481.2021.1982298   
2021 Sun J, Liu HY, Zhang YH, Fang ZY, Lv PC. Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorganic Chemistry. 116: 105342. PMID 34536928 DOI: 10.1016/j.bioorg.2021.105342   
2021 Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033   
2021 Neumann WL, Sandoval KE, Mobayen S, Minaeian M, Kukielski SG, Srabony KN, Frare R, Slater O, Farr SA, Niehoff ML, Hospital A, Kontoyianni M, Crider AM, Witt KA. Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment. Rsc Medicinal Chemistry. 12: 1352-1365. PMID 34458738 DOI: 10.1039/d1md00044f   
2021 Misery L, Brenaut E, Pierre O, Le Garrec R, Gouin O, Lebonvallet N, Abasq-Thomas C, Talagas M, Le Gall-Ianotto C, Besner-Morin C, Fluhr JW, Leven C. CHRONIC ITCH: EMERGING TREATMENTS FOLLOWING NEW RESEARCH CONCEPTS. British Journal of Pharmacology. PMID 34463358 DOI: 10.1111/bph.15672   
2021 Leo LM, Abood ME. CB1 Cannabinoid Receptor Signaling and Biased Signaling. Molecules (Basel, Switzerland). 26. PMID 34500853 DOI: 10.3390/molecules26175413   
2021 Malyshev AV, Sukhanova IA, Zlobin AS, Gedzun VR, Pavshintsev VV, Vasileva EV, Zalevsky AO, Doronin II, Mitkin NA, Golovin AV, Lovat ML, Kovalev GI, Zolotarev YA, Kuchumov AR, Babkin GA, et al. Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties. Frontiers in Neuroscience. 15: 705590. PMID 34421525 DOI: 10.3389/fnins.2021.705590   
2021 Waters K. Pharmacologic Similarities and Differences Among Hallucinogens. Journal of Clinical Pharmacology. 61: S100-S113. PMID 34396556 DOI: 10.1002/jcph.1917   
2021 Berthier A, Staels B, Lefebvre P. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. Star Protocols. 2: 100658. PMID 34286290 DOI: 10.1016/j.xpro.2021.100658   
2021 Duan W, Sun Y, Wu M, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T, Nie H, Cheng J. Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. European Journal of Medicinal Chemistry. 226: 113878. PMID 34634742 DOI: 10.1016/j.ejmech.2021.113878   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141   
2021 Krautmann M, Walters R, Cole P, Tena J, Bergeron LM, Messamore J, Mwangi D, Rai S, Dominowski P, Saad K, Zhu Y, Guillot M, Chouinard L. Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs. Veterinary Journal (London, England : 1997). 276: 105733. PMID 34391918 DOI: 10.1016/j.tvjl.2021.105733   
2021 Brown JD, Rivera Rivera KJ, Hernandez LYC, Doenges MR, Auchey I, Pham T, Goodin AJ. Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions. Journal of Clinical Pharmacology. 61: S37-S52. PMID 34396558 DOI: 10.1002/jcph.1871   
2021 Matsumoto R, Takahashi D, Watanabe M, Nakatani S, Takamura Y, Kurosaki Y, Kakuta H, Hase K. A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice. Frontiers in Pharmacology. 12: 715752. PMID 34475823 DOI: 10.3389/fphar.2021.715752   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005   
2021 Antonoudiou P, Colmers PLW, Walton NL, Weiss GL, Smith AC, Nguyen DP, Lewis M, Quirk MC, Barros L, Melon LC, Maguire JL. Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala. Biological Psychiatry. PMID 34561029 DOI: 10.1016/j.biopsych.2021.07.017   
2021 Pankiewicz P, Szybiński M, Kisielewska K, Gołębiowski F, Krzemiński P, Rutkowska-Włodarczyk I, Moszczyński-Pętkowski R, Gurba-Bryśkiewicz L, Delis M, Mulewski K, Smuga D, Dominowski J, Janusz A, Górka M, Abramski K, et al. Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451801 DOI: 10.3390/ph14080704   
2021 Ding G, Li D, Sun Y, Chen K, Song D. -Opioid Receptor Agonist Ameliorates Postoperative Neurocognitive Disorder by Activating the Ca/CaMKII/CREB Pathway. Journal of Healthcare Engineering. 2021: 3401654. PMID 34608407 DOI: 10.1155/2021/3401654   
2021 Cao AM, Quast RB, Fatemi F, Rondard P, Pin JP, Margeat E. Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state. Nature Communications. 12: 5426. PMID 34521824 DOI: 10.1038/s41467-021-25620-5   
2021 Galiazzo G, De Silva M, Giancola F, Rinnovati R, Peli A, Chiocchetti R. Cellular distribution of cannabinoid-related receptors TRPV1, PPAR-gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia. Equine Veterinary Journal. PMID 34418142 DOI: 10.1111/evj.13499   
2021 León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, et al. Activity of ("Kratom") Alkaloids at Serotonin Receptors. Journal of Medicinal Chemistry. PMID 34467758 DOI: 10.1021/acs.jmedchem.1c00726   
2021 LoRusso P, Hamilton E, Ma C, Vidula N, Bagley RG, Troy S, Annett M, Yu Z, Conlan MG, Weise A. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer. Clinical Breast Cancer. PMID 34565686 DOI: 10.1016/j.clbc.2021.08.003   
2021 Han J, Andreu V, Langreck C, Pekarskaya EA, Grinnell SG, Allain F, Magalong V, Pintar J, Kieffer BL, Harris AZ, Javitch JA, Hen R, Nautiyal KM. Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34593976 DOI: 10.1038/s41386-021-01192-2   
2021 Mazeh AC, Angus JA, Wright CE. Pharmacological characterisation of the CB receptor antagonist activity of cannabidiol in the rat vas deferens bioassay. European Journal of Pharmacology. 174433. PMID 34416240 DOI: 10.1016/j.ejphar.2021.174433   
2021 Li Z, Ren Q, Zhou Z, Cai Z, Wang B, Han J, Zhang L. Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome. European Journal of Medicinal Chemistry. 225: 113807. PMID 34455359 DOI: 10.1016/j.ejmech.2021.113807