Luiz Pedro S. de Carvalho, Ph.D. - Publications

Affiliations: 
2001-2006 Biochemistry The Francis Crick Institute 
Area:
Enzymology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS. D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition. Nature Chemical Biology. PMID 32203411 DOI: 10.1038/S41589-020-0498-9  1
2019 Evangelopoulos D, Prosser GA, Rodgers A, Dagg BM, Khatri B, Ho MM, Gutierrez MG, Cortes T, de Carvalho LPS. Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes. Nature Communications. 10: 4177. PMID 31519879 DOI: 10.1038/s41467-019-12074-z  1
2019 Serafini A, Tan L, Horswell S, Howell S, Greenwood DJ, Hunt DM, Phan MD, Schembri M, Monteleone M, Montague CR, Britton W, Garza-Garcia A, Snijders AP, VanderVen B, Gutierrez MG, ... ... de Carvalho LPS, et al. Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology. PMID 31389636 DOI: 10.1111/Mmi.14362  1
2019 Wang H, Fedorov AA, Fedorov EV, Hunt DM, Rodgers A, Douglas HL, Garza-Garcia A, Bonanno JB, Almo SC, de Carvalho LPS. An essential bifunctional enzyme in for itaconate dissimilation and leucine catabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 31320588 DOI: 10.1073/pnas.1906606116  1
2019 Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, ... ... de Carvalho LPS, et al. An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Molecular Cell. PMID 30792174 DOI: 10.1016/J.Molcel.2019.01.028  1
2019 Agapova A, Serafini A, Petridis M, Hunt DM, Garza-Garcia A, Sohaskey CD, de Carvalho LPS. Flexible nitrogen utilisation by the metabolic generalist pathogen . Elife. 8. PMID 30702426 DOI: 10.7554/eLife.41129  1
2018 Craggs PD, Mouilleron S, Rejzek M, Chiara C, Young RJ, Field RA, Argyrou A, de Carvalho LPS. On the catalytic mechanism of acetyl transfer catalysed by Mycobacterium tuberculosis GlmU. Biochemistry. PMID 29684272 DOI: 10.1021/acs.biochem.8b00121  1
2017 Fernandes GFDS, De Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, Da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, ... ... de Carvalho LPS, et al. Design, Synthesis and Characterization of N-oxide-containing Heterocycles with In vivo Sterilizing Antitubercular Activity. Journal of Medicinal Chemistry. PMID 28968083 DOI: 10.1021/acs.jmedchem.7b01332  1
2017 Ley SC, de Carvalho LPS. Protein CoAlation: a redox-linked post-translational modification. The Biochemical Journal. 474: 2897-2899. PMID 28798160 DOI: 10.1042/BCJ20170168  0.12
2017 Pacholarz KJ, Burnley RJ, Jowitt TA, Ordsmith V, Pisco JP, Porrini M, Larrouy-Maumus G, Garlish RA, Taylor RJ, de Carvalho LP, Barran PE. Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase. Structure (London, England : 1993). PMID 28392260 DOI: 10.1016/j.str.2017.03.005  1
2016 Prosser GA, Rodenburg A, Khoury H, de Chiara C, Howell S, Snijders AP, de Carvalho LP. Glutamate racemase is the primary target of β-chloro-D-alanine in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 27480853 DOI: 10.1128/AAC.01249-16  1
2016 Larrouy-Maumus G, Marino LB, Madduri AV, Ragan TJ, Hunt DM, Bassano L, Gutierrez MG, Moody DB, Pavan FR, de Carvalho LP. Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 352-360. PMID 27231718 DOI: 10.1021/acsinfecdis.5b00148  1
2016 Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. Journal of Medicinal Chemistry. 59: 3272-302. PMID 27002486 DOI: 10.1021/Acs.Jmedchem.6B00007  1
2015 Prosser GA, de Carvalho LP. Correction to Reinterpreting the Mechanism of Inhibition of Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase by d-Cycloserine. Biochemistry. 54: 8386. PMID 26539621 DOI: 10.1021/bi401445y  1
2015 Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis. Nature Communications. 6: 7912. PMID 26258286 DOI: 10.1038/Ncomms8912  1
2015 Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, ... ... de Carvalho LP, et al. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG. Chemistry & Biology. 22: 917-27. PMID 26097035 DOI: 10.1016/j.chembiol.2015.05.016  0.01
2015 Young DB, Comas I, de Carvalho LP. Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis. Frontiers in Molecular Biosciences. 2: 6. PMID 25988174 DOI: 10.3389/Fmolb.2015.00006  0.01
2015 Nandakumar M, Prosser GA, de Carvalho LP, Rhee K. Metabolomics of Mycobacterium tuberculosis. Methods in Molecular Biology (Clifton, N.J.). 1285: 105-15. PMID 25779312 DOI: 10.1007/978-1-4939-2450-9_6  1
2015 Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, et al. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.05.016  1
2014 Prosser GA, Larrouy-Maumus G, de Carvalho LP. Metabolomic strategies for the identification of new enzyme functions and metabolic pathways. Embo Reports. 15: 657-69. PMID 24829223 DOI: 10.15252/embr.201338283  1
2014 Larrouy-Maumus G, Kelly G, de Carvalho LP. Chemical mechanism of glycerol 3-phosphate phosphatase: pH-dependent changes in the rate-limiting step. Biochemistry. 53: 143-51. PMID 24359335 DOI: 10.1021/bi400856y  1
2013 Prosser GA, de Carvalho LP. Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 4: 1233-1237. PMID 24478820 DOI: 10.1021/ml400349n  1
2013 Gouzy A, Larrouy-Maumus G, Wu TD, Peixoto A, Levillain F, Lugo-Villarino G, Guerquin-Kern JL, Gerquin-Kern JL, de Carvalho LP, Poquet Y, Neyrolles O. Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Nature Chemical Biology. 9: 674-6. PMID 24077180 DOI: 10.1038/Nchembio.1355  1
2013 Prosser GA, de Carvalho LP. Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine. Biochemistry. 52: 7145-9. PMID 24033232 DOI: 10.1021/bi400839f  1
2013 Larrouy-Maumus G, Biswas T, Hunt DM, Kelly G, Tsodikov OV, de Carvalho LP. Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 11320-5. PMID 23801751 DOI: 10.1073/pnas.1221597110  1
2013 Mao C, Shukla M, Larrouy-Maumus G, Dix FL, Kelley LA, Sternberg MJ, Sobral BW, de Carvalho LP. Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition. Tuberculosis (Edinburgh, Scotland). 93: 40-6. PMID 23287603 DOI: 10.1016/j.tube.2012.11.008  1
2013 Prosser GA, de Carvalho LP. Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine. The Febs Journal. 280: 1150-66. PMID 23286234 DOI: 10.1111/febs.12108  1
2012 Pedreño S, Pisco JP, Larrouy-Maumus G, Kelly G, de Carvalho LP. Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase. Biochemistry. 51: 8027-38. PMID 22989207 DOI: 10.1021/bi300808b  1
2011 de Carvalho LP, Darby CM, Rhee KY, Nathan C. Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. Acs Medicinal Chemistry Letters. 2: 849-854. PMID 22096616 DOI: 10.1021/Ml200157F  1
2011 Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, Walker PA, Kelly G, Haire LF, Yap MW, de Carvalho LP, Stoye JP, Crow YJ, Taylor IA, Webb M. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature. 480: 379-82. PMID 22056990 DOI: 10.1038/nature10623  1
2011 Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in Microbiology. 19: 307-14. PMID 21561773 DOI: 10.1016/J.Tim.2011.03.008  0.24
2011 de Carvalho LP, Ling Y, Shen C, Warren JD, Rhee KY. On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics. 509: 90-9. PMID 21303655 DOI: 10.1016/j.abb.2011.01.023  1
2010 de Carvalho LP, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY. Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & Biology. 17: 1122-31. PMID 21035735 DOI: 10.1016/J.Chembiol.2010.08.009  1
2010 Zhao H, de Carvalho LP, Nathan C, Ouerfelli O. A protecting group-free synthesis of deazathiamine: a step toward inhibitor design. Bioorganic & Medicinal Chemistry Letters. 20: 6472-4. PMID 20943392 DOI: 10.1016/J.Bmcl.2010.09.053  1
2010 de Carvalho LP, Zhao H, Dickinson CE, Arango NM, Lima CD, Fischer SM, Ouerfelli O, Nathan C, Rhee KY. Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase. Chemistry & Biology. 17: 323-32. PMID 20416504 DOI: 10.1016/J.Chembiol.2010.03.009  1
2009 Lin G, Li D, de Carvalho LP, Deng H, Tao H, Vogt G, Wu K, Schneider J, Chidawanyika T, Warren JD, Li H, Nathan C. Inhibitors selective for mycobacterial versus human proteasomes. Nature. 461: 621-6. PMID 19759536 DOI: 10.1038/Nature08357  1
2009 de Carvalho LP, Lin G, Jiang X, Nathan C. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Journal of Medicinal Chemistry. 52: 5789-92. PMID 19736929 DOI: 10.1021/Jm9010719  1
2009 De Carvalho LPS, Frantom PA, Argyrou A, Blanchard JS. Kinetic evidence for interdomain communication in the allosteric regulation of α-isopropylmalate synthase from Mycobacterium tuberculosis Biochemistry. 48: 1996-2004. PMID 19166329 DOI: 10.1021/Bi801707T  1
2009 Lee WL, Gold B, Darby C, Brot N, Jiang X, de Carvalho LP, Wellner D, St John G, Jacobs WR, Nathan C. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular Microbiology. 71: 583-93. PMID 19040639 DOI: 10.1111/J.1365-2958.2008.06548.X  1
2008 Nathan C, Gold B, Lin G, Stegman M, de Carvalho LP, Vandal O, Venugopal A, Bryk R. A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 88: S25-33. PMID 18762150 DOI: 10.1016/S1472-9792(08)70034-9  1
2006 Yu M, De Carvalho LPS, Sun G, Blanchard JS. Activity-based substrate profiling for Gcn5-related N-acetyltransferases: The use of chloroacetyl-coenzyme A to identify protein substrates Journal of the American Chemical Society. 128: 15356-15357. PMID 17131985 DOI: 10.1021/Ja066298W  1
2006 Silva RG, De Carvalho LPS, Blanchard JS, Santos DS, Basso LA. Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein (ACP) reductase: Kinetic and chemical mechanisms Biochemistry. 45: 13064-13073. PMID 17059223 DOI: 10.1021/Bi0611210  1
2006 De Carvalho LPS, Blanchard JS. Kinetic and chemical mechanism of α-isopropylmalate synthase from Mycobacterium tuberculosis Biochemistry. 45: 8988-8999. PMID 16846242 DOI: 10.1021/Bi0606602  1
2006 de Carvalho LPS, Blanchard JS. Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis α-isopropylmalate synthase Archives of Biochemistry and Biophysics. 451: 141-148. PMID 16684501 DOI: 10.1016/J.Abb.2006.03.030  1
2005 De Carvalho LPS, Argyrou A, Blanchard JS. Slow-onset feedback inhibition: Inhibition of Mycobacterium tuberculosis α-isopropylmalate synthase by L-leucine Journal of the American Chemical Society. 127: 10004-10005. PMID 16011356 DOI: 10.1021/Ja052513H  1
2005 Vetting MW, De Carvalho LPS, Roderick SL, Blanchard JS. A novel dimeric structure of the RimL Nα-acetyltransferase from Salmonella typhimurium Journal of Biological Chemistry. 280: 22108-22114. PMID 15817456 DOI: 10.1074/Jbc.M502401200  1
2004 Poletto SS, da Fonseca IO, de Carvalho LP, Basso LA, Santos DS. Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes. Protein Expression and Purification. 34: 118-25. PMID 14766307 DOI: 10.1016/j.pep.2003.10.009  1
2003 de Azevedo WF, Canduri F, dos Santos DM, Silva RG, de Oliveira JS, de Carvalho LP, Basso LA, Mendes MA, Palma MS, Santos DS. Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution. Biochemical and Biophysical Research Communications. 308: 545-52. PMID 12914785  1
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