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Robert M. Brownstone, MD, PhD - Publications

Affiliations: 
1995-2000 Surgery University of Manitoba, Winnipeg, Manitoba, Canada 
 2000-2015 Dalhousie University, Halifax, Nova Scotia, Canada 
 2015- Institute of Neurology University College London, London, United Kingdom 
Area:
Spinal cord, neural circuits for movement
Website:
http://motorcontrol.medicine.dal.ca/
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71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Özyurt MG, Nascimento F, Brownstone RM, Beato M. On the origin of F-wave: involvement of central synaptic mechanisms. Brain : a Journal of Neurology. PMID 37796028 DOI: 10.1093/brain/awad342  0.791
2023 Pocratsky AM, Nascimento F, Özyurt MG, White IJ, Sullivan R, O'Callaghan BJ, Smith CC, Surana S, Beato M, Brownstone RM. Pathophysiology of Dyt1- dystonia in mice is mediated by spinal neural circuit dysfunction. Science Translational Medicine. 15: eadg3904. PMID 37134150 DOI: 10.1126/scitranslmed.adg3904  0.819
2022 Ronzano R, Skarlatou S, Barriga BK, Bannatyne BA, Bhumbra GS, Foster JD, Moore JD, Lancelin C, Pocratsky AM, Özyurt MG, Smith CC, Todd AJ, Maxwell DJ, Murray AJ, Pfaff SL, ... Brownstone RM, et al. Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled. Elife. 11. PMID 36512397 DOI: 10.7554/eLife.81976  0.84
2022 Smith CC, Brownstone RM. Electrical Properties of Adult Mammalian Motoneurons. Advances in Neurobiology. 28: 191-232. PMID 36066827 DOI: 10.1007/978-3-031-07167-6_9  0.38
2022 Thiry L, Lemaire C, Rastqar A, Lemieux M, Peng J, Ferent J, Roussel M, Beaumont E, Fawcett JP, Brownstone RM, Charron F, Bretzner F. Heterozygous mutant mice have a subtle locomotor phenotype. Eneuro. PMID 35115383 DOI: 10.1523/ENEURO.0216-18.2021  0.36
2021 Ronzano R, Lancelin C, Bhumbra GS, Brownstone RM, Beato M. Proximal and distal spinal neurons innervating multiple synergist and antagonist motor pools. Elife. 10. PMID 34727018 DOI: 10.7554/eLife.70858  0.847
2021 Chopek JW, Zhang Y, Brownstone RM. Intrinsic brainstem circuits comprised of Chx10-expressing neurons contribute to reticulospinal output in mice. Journal of Neurophysiology. PMID 34669520 DOI: 10.1152/jn.00322.2021  0.797
2021 Koronfel LM, Kanning KC, Alcos A, Henderson CE, Brownstone RM. Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion. Scientific Reports. 11: 16008. PMID 34362940 DOI: 10.1038/s41598-021-95143-y  0.401
2020 Smith CC, Brownstone RM. Spinal motoneuron firing properties mature from rostral to caudal during post-natal development of the mouse. The Journal of Physiology. PMID 32851667 DOI: 10.1113/Jp280274  0.56
2020 Brownstone RM. Key steps in the evolution of mammalian movement: a prolegomenal essay. Neuroscience. PMID 32446854 DOI: 10.1016/j.neuroscience.2020.05.020  0.453
2019 Chopek JW, Hultborn H, Brownstone RM. Multistable properties of human subthalamic nucleus neurons in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 31712414 DOI: 10.1073/pnas.1912128116  0.79
2018 Jensen MP, Brownstone RM. Mechanisms of Spinal Cord Stimulation for the Treatment of Pain: Still in the Dark after 50 Years. European Journal of Pain (London, England). PMID 30407696 DOI: 10.1002/ejp.1336  0.409
2018 Chopek JW, Nascimento F, Beato M, Brownstone RM, Zhang Y. Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits. Cell Reports. 25: 146-156.e3. PMID 30282024 DOI: 10.1016/J.Celrep.2018.08.095  0.78
2018 Whatley BP, Chopek JW, Hill R, Brownstone RM. Case Studies in Neuroscience: Evidence of motor thalamus reorganization following bilateral forearm amputations. Journal of Neurophysiology. PMID 29847233 DOI: 10.1152/jn.00120.2018  0.805
2018 Brownstone RM, Chopek JW. Reticulospinal Systems for Tuning Motor Commands. Frontiers in Neural Circuits. 12: 30. PMID 29720934 DOI: 10.3389/fncir.2018.00030  0.814
2018 Brownstone RM, Lancelin C. Escape From Homeostasis: Spinal Microcircuits And Progression Of Amyotrophic Lateral Sclerosis. Journal of Neurophysiology. PMID 29384454 DOI: 10.1152/jn.00331.2017  0.814
2017 Magown P, Rafuse VF, Brownstone RM. Microcircuit formation following transplantation of mouse embryonic stem cell-derived neurons into peripheral nerve. Journal of Neurophysiology. jn.00943.2016. PMID 28148646 DOI: 10.1152/Jn.00943.2016  0.413
2016 Bui TV, Stifani N, Akay T, Brownstone RM. Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection. Elife. 5. PMID 27977000 DOI: 10.7554/Elife.21715  0.845
2016 Magown P, Brownstone RM, Rafuse VF. Tumor prevention facilitates delayed transplant of stem cell-derived motoneurons. Annals of Clinical and Translational Neurology. 3: 637-49. PMID 27606345 DOI: 10.1002/Acn3.327  0.335
2016 Bui TV, Stifani N, Akay T, Brownstone RM. Author response: Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection Elife. DOI: 10.7554/Elife.21715.036  0.829
2015 Radic JA, Beauprie I, Chiasson P, Kiss ZH, Brownstone RM. Motor Cortex Stimulation for Neuropathic Pain: A Randomized Cross-over Trial. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 1-9. PMID 26324857 DOI: 10.1017/cjn.2015.292  0.31
2015 Brownstone RM, Bui TV, Stifani N. Spinal circuits for motor learning. Current Opinion in Neurobiology. 33: 166-73. PMID 25978563 DOI: 10.1016/J.Conb.2015.04.007  0.826
2015 Brownstone RM, Stifani N. Unraveling a locomotor network, many neurons at a time. Neuron. 86: 9-11. PMID 25856478 DOI: 10.1016/J.Neuron.2015.03.056  0.781
2015 Bui TV, Brownstone RM. Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study. Journal of Neurophysiology. 113: 2824-39. PMID 25673740 DOI: 10.1152/jn.00866.2014  0.708
2015 Brownstone RM, Bui TV, Stifani N. Spinal circuits for motor learning Current Opinion in Neurobiology. 33. DOI: 10.1016/j.conb.2015.04.007  0.817
2014 Panek I, Bui T, Wright AT, Brownstone RM. Cutaneous afferent regulation of motor function. Acta Neurobiologiae Experimentalis. 74: 158-71. PMID 24993626  0.67
2014 Müller D, Cherukuri P, Henningfeld K, Poh CH, Wittler L, Grote P, Schlüter O, Schmidt J, Laborda J, Bauer SR, Brownstone RM, Marquardt T. Dlk1 promotes a fast motor neuron biophysical signature required for peak force execution. Science (New York, N.Y.). 343: 1264-6. PMID 24626931 DOI: 10.1126/science.1246448  0.665
2013 Bretzner F, Brownstone RM. Lhx3-Chx10 reticulospinal neurons in locomotor circuits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14681-92. PMID 24027269 DOI: 10.1523/Jneurosci.5231-12.2013  0.534
2013 Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, Brownstone RM. Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron. 78: 191-204. PMID 23583114 DOI: 10.1016/J.Neuron.2013.02.007  0.758
2013 Brownstone RM, Magown P. Matchmaking: SK channels, C-boutons and motor units. The Journal of Physiology. 591: 747-8. PMID 23418370 DOI: 10.1113/jphysiol.2012.249573  0.391
2012 Mitra P, Brownstone RM. An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. Journal of Neurophysiology. 107: 728-41. PMID 22031766 DOI: 10.1152/Jn.00558.2011  0.495
2012 Anderson TM, Abbinanti MD, Peck JH, Gilmour M, Brownstone RM, Masino MA. Low-threshold calcium currents contribute to locomotor-like activity in neonatal mice. Journal of Neurophysiology. 107: 103-13. PMID 21994264 DOI: 10.1152/Jn.00583.2011  0.413
2011 Stuart DG, Clarac F, Barbara JG, Brownstone RM, Duchateau J, Enoka RM. Paths of discovery in motoneuron neurobiology. Brain Research. 1409: 1-2. PMID 21864736 DOI: 10.1016/j.brainres.2011.07.035  0.336
2011 Stuart DG, Brownstone RM. The beginning of intracellular recording in spinal neurons: facts, reflections, and speculations. Brain Research. 1409: 62-92. PMID 21782158 DOI: 10.1016/j.brainres.2011.06.007  0.442
2011 Bretzner F, Gilbert F, Baylis F, Brownstone RM. Target populations for first-in-human embryonic stem cell research in spinal cord injury. Cell Stem Cell. 8: 468-75. PMID 21549321 DOI: 10.1016/J.Stem.2011.04.012  0.336
2011 Brownstone RM, Krawitz S, Jordan LM. Reversal of the late phase of spike frequency adaptation in cat spinal motoneurons during fictive locomotion. Journal of Neurophysiology. 105: 1045-50. PMID 21177992 DOI: 10.1152/jn.00411.2010  0.704
2010 Brownstone RM, Bui TV. Spinal interneurons providing input to the final common path during locomotion. Progress in Brain Research. 187: 81-95. PMID 21111202 DOI: 10.1016/B978-0-444-53613-6.00006-X  0.734
2010 Wilson JM, Blagovechtchenski E, Brownstone RM. Genetically defined inhibitory neurons in the mouse spinal cord dorsal horn: a possible source of rhythmic inhibition of motoneurons during fictive locomotion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1137-48. PMID 20089922 DOI: 10.1523/JNEUROSCI.1401-09.2010  0.572
2009 Zagoraiou L, Akay T, Martin JF, Brownstone RM, Jessell TM, Miles GB. A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron. 64: 645-62. PMID 20005822 DOI: 10.1016/J.Neuron.2009.10.017  0.839
2009 Dai Y, Carlin KP, Li Z, McMahon DG, Brownstone RM, Jordan LM. Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice. Journal of Neurophysiology. 102: 3365-83. PMID 19793882 DOI: 10.1152/jn.00265.2009  0.662
2009 Carlin KP, Bui TV, Dai Y, Brownstone RM. Staircase currents in motoneurons: insight into the spatial arrangement of calcium channels in the dendritic tree. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5343-53. PMID 19386931 DOI: 10.1523/JNEUROSCI.5458-08.2009  0.698
2008 Yohn DC, Miles GB, Rafuse VF, Brownstone RM. Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12409-18. PMID 19020033 DOI: 10.1523/Jneurosci.1761-08.2008  0.783
2008 Mukhida K, Hong M, Miles GB, Phillips T, Baghbaderani BA, McLeod M, Kobayashi N, Sen A, Behie LA, Brownstone RM, Mendez I. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats. Brain : a Journal of Neurology. 131: 2106-26. PMID 18669492 DOI: 10.1093/Brain/Awn149  0.767
2008 Brownstone RM, Wilson JM. Strategies for delineating spinal locomotor rhythm-generating networks and the possible role of Hb9 interneurones in rhythmogenesis. Brain Research Reviews. 57: 64-76. PMID 17905441 DOI: 10.1016/j.brainresrev.2007.06.025  0.492
2007 Al-Mosawie A, Wilson JM, Brownstone RM. Heterogeneity of V2-derived interneurons in the adult mouse spinal cord. The European Journal of Neuroscience. 26: 3003-15. PMID 18028108 DOI: 10.1111/j.1460-9568.2007.05907.x  0.511
2007 Wilson JM, Cowan AI, Brownstone RM. Heterogeneous electrotonic coupling and synchronization of rhythmic bursting activity in mouse Hb9 interneurons. Journal of Neurophysiology. 98: 2370-81. PMID 17715199 DOI: 10.1152/jn.00338.2007  0.535
2007 Hebb MO, Chiasson P, Lang AE, Brownstone RM, Mendez I. Sustained relief of dystonia following cessation of deep brain stimulation. Movement Disorders : Official Journal of the Movement Disorder Society. 22: 1958-62. PMID 17674409 DOI: 10.1002/Mds.21616  0.334
2007 Brownstone RM. Take Your PIC: motoneuronal persistent inward currents may be somatic as well as dendritic. focus on "facilitation of somatic calcium channels can evoke prolonged tail currents in rat hypoglossal motoneurons". Journal of Neurophysiology. 98: 579-80. PMID 17522171 DOI: 10.1152/jn.00388.2007  0.343
2007 Wilson JM, Dombeck DA, Díaz-Ríos M, Harris-Warrick RM, Brownstone RM. Two-photon calcium imaging of network activity in XFP-expressing neurons in the mouse. Journal of Neurophysiology. 97: 3118-25. PMID 17303810 DOI: 10.1152/Jn.01207.2006  0.496
2007 Miles GB, Hartley R, Todd AJ, Brownstone RM. Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion. Proceedings of the National Academy of Sciences of the United States of America. 104: 2448-53. PMID 17287343 DOI: 10.1073/Pnas.0611134104  0.85
2006 Carlin KP, Brownstone RM. Rapid pH and PO2 changes in the tissue recording chamber during stoppage of a gas-equilibrated perfusate: effects on calcium currents in ventral horn neurons. The European Journal of Neuroscience. 24: 1353-8. PMID 16965545 DOI: 10.1111/j.1460-9568.2006.05018.x  0.313
2006 Brownstone RM. Beginning at the end: repetitive firing properties in the final common pathway. Progress in Neurobiology. 78: 156-72. PMID 16725251 DOI: 10.1016/j.pneurobio.2006.04.002  0.48
2006 Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF. Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3256-68. PMID 16554476 DOI: 10.1523/Jneurosci.5537-05.2006  0.794
2005 Wilson JM, Hartley R, Maxwell DJ, Todd AJ, Lieberam I, Kaltschmidt JA, Yoshida Y, Jessell TM, Brownstone RM. Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5710-9. PMID 15958737 DOI: 10.1523/Jneurosci.0274-05.2005  0.481
2005 Miles GB, Dai Y, Brownstone RM. Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones. The Journal of Physiology. 566: 519-32. PMID 15878947 DOI: 10.1113/Jphysiol.2005.086033  0.804
2004 Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, Brownstone RM. Functional properties of motoneurons derived from mouse embryonic stem cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7848-58. PMID 15356197 DOI: 10.1523/Jneurosci.1972-04.2004  0.778
2004 Wilson JM, Rempel J, Brownstone RM. Postnatal development of cholinergic synapses on mouse spinal motoneurons. The Journal of Comparative Neurology. 474: 13-23. PMID 15156576 DOI: 10.1002/cne.20089  0.442
2003 Heckman CJ, Lee RH, Brownstone RM. Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior. Trends in Neurosciences. 26: 688-95. PMID 14624854 DOI: 10.1016/J.Tins.2003.10.002  0.476
2003 MacDonald SC, Fleetwood IG, Hochman S, Dodd JG, Cheng GK, Jordan LM, Brownstone RM. Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve. Journal of Neurosurgery. 98: 1094-103. PMID 12744371 DOI: 10.3171/Jns.2003.98.5.1094  0.798
2003 Noga BR, Kriellaars DJ, Brownstone RM, Jordan LM. Mechanism for activation of locomotor centers in the spinal cord by stimulation of the mesencephalic locomotor region. Journal of Neurophysiology. 90: 1464-78. PMID 12634275 DOI: 10.1152/Jn.00034.2003  0.813
2000 Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM. Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. The European Journal of Neuroscience. 12: 1635-46. PMID 10792441 DOI: 10.1046/j.1460-9568.2000.00055.x  0.727
2000 Carlin KP, Jiang Z, Brownstone RM. Characterization of calcium currents in functionally mature mouse spinal motoneurons. The European Journal of Neuroscience. 12: 1624-34. PMID 10792440 DOI: 10.1046/j.1460-9568.2000.00050.x  0.471
2000 Jones KE, Carlin KP, Rempel J, Jordan LM, Brownstone RM. Simulation techniques for localising and identifying the kinetics of calcium channels in dendritic neurones Neurocomputing. 32: 173-180. DOI: 10.1016/S0925-2312(00)00160-0  0.689
1999 Jiang Z, Rempel J, Li J, Sawchuk MA, Carlin KP, Brownstone RM. Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord. The European Journal of Neuroscience. 11: 3481-7. PMID 10564356 DOI: 10.1046/j.1460-9568.1999.00765.x  0.45
1999 Jiang Z, Carlin KP, Brownstone RM. An in vitro functionally mature mouse spinal cord preparation for the study of spinal motor networks. Brain Research. 816: 493-9. PMID 9878874 DOI: 10.1016/S0006-8993(98)01199-8  0.525
1998 Hultborn H, Conway BA, Gossard JP, Brownstone R, Fedirchuk B, Schomburg ED, Enríquez-Denton M, Perreault MC. How do we approach the locomotor network in the mammalian spinal cord? Annals of the New York Academy of Sciences. 860: 70-82. PMID 9928302 DOI: 10.1111/J.1749-6632.1998.Tb09039.X  0.821
1994 Gossard JP, Brownstone RM, Barajon I, Hultborn H. Transmission in a locomotor-related group Ib pathway from hindlimb extensor muscles in the cat. Experimental Brain Research. 98: 213-28. PMID 8050508 DOI: 10.1007/BF00228410  0.803
1994 Kriellaars DJ, Brownstone RM, Noga BR, Jordan LM. Mechanical entrainment of fictive locomotion in the decerebrate cat. Journal of Neurophysiology. 71: 2074-86. PMID 7931503 DOI: 10.1152/Jn.1994.71.6.2074  0.783
1994 Brownstone RM, Gossard JP, Hultborn H. Voltage-dependent excitation of motoneurones from spinal locomotor centres in the cat. Experimental Brain Research. 102: 34-44. PMID 7895797 DOI: 10.1007/BF00232436  0.799
1992 Brownstone RM, Jordan LM, Kriellaars DJ, Noga BR, Shefchyk SJ. On the regulation of repetitive firing in lumbar motoneurones during fictive locomotion in the cat. Experimental Brain Research. 90: 441-55. PMID 1426105 DOI: 10.1007/Bf00230927  0.805
1992 Jordan LM, Brownstone RM, Noga BR. Control of functional systems in the brainstem and spinal cord. Current Opinion in Neurobiology. 2: 794-801. PMID 1362109 DOI: 10.1016/0959-4388(92)90136-9  0.782
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