Mei-Chu Lo, Ph.D. - Publications

Affiliations: 
2000 Princeton University, Princeton, NJ 
Area:
Chemical biology, enzymology, antibiotics, glycosyltransferases, inhibitors

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Rew Y, Sun D, Yan X, Beck HP, Canon J, Chen A, Duquette J, Eksterowicz J, Fox BM, Fu J, Gonzalez AZ, Houze J, Huang X, Jiang M, Jin L, ... ... Lo MC, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. Journal of Medicinal Chemistry. 57: 10499-511. PMID 25384157 DOI: 10.1021/jm501550p  0.76
2014 Yu M, Wang Y, Zhu J, Bartberger MD, Canon J, Chen A, Chow D, Eksterowicz J, Fox B, Fu J, Gribble M, Huang X, Li Z, Liu JJ, Lo MC, et al. Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction. Acs Medicinal Chemistry Letters. 5: 894-9. PMID 25147610 DOI: 10.1021/ml500142b  0.76
2014 Wang Y, Zhu J, Liu JJ, Chen X, Mihalic J, Deignan J, Yu M, Sun D, Kayser F, McGee LR, Lo MC, Chen A, Zhou J, Ye Q, Huang X, et al. Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters. 24: 3782-5. PMID 25042256 DOI: 10.1016/j.bmcl.2014.06.073  0.76
2014 Li Z, Wang X, Eksterowicz J, Gribble MW, Alba GQ, Ayres M, Carlson TJ, Chen A, Chen X, Cho R, Connors RV, DeGraffenreid M, Deignan JT, Duquette J, Fan P, ... ... Lo MC, et al. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. Journal of Medicinal Chemistry. 57: 3430-49. PMID 24641103 DOI: 10.1021/jm500118j  0.76
2014 Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, ... Lo MC, et al. Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. Journal of Medicinal Chemistry. 57: 2963-88. PMID 24601644 DOI: 10.1021/jm401911v  0.76
2014 Gonzalez AZ, Eksterowicz J, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Duquette J, Fox BM, Fu J, Huang X, Houze JB, Jin L, Li Y, Li Z, ... ... Lo MC, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. Journal of Medicinal Chemistry. 57: 2472-88. PMID 24548297 DOI: 10.1021/jm401767k  0.76
2014 Keegan K, Li C, Li Z, Ma J, Ragains M, Coberly S, Hollenback D, Eksterowicz J, Liang L, Weidner M, Huard J, Wang X, Alba G, Orf J, Lo MC, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Molecular Cancer Therapeutics. 13: 880-9. PMID 24526162 DOI: 10.1158/1535-7163.MCT-13-0858  0.76
2014 Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, Canon J, Chen A, Chen X, Chow D, Deignan J, Duquette J, Eksterowicz J, Fisher B, Fox BM, ... ... Lo MC, et al. Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development. Journal of Medicinal Chemistry. 57: 1454-72. PMID 24456472 DOI: 10.1021/jm401753e  0.76
2013 Gonzalez-Lopez de Turiso F, Sun D, Rew Y, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Correll TL, Huang X, Julian LD, Kayser F, Lo MC, Long AM, McMinn D, et al. Rational design and binding mode duality of MDM2-p53 inhibitors. Journal of Medicinal Chemistry. 56: 4053-70. PMID 23597064 DOI: 10.1021/jm400293z  0.76
2012 Rew Y, Sun D, Gonzalez-Lopez De Turiso F, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Deignan J, Fox BM, Gustin D, Huang X, Jiang M, Jiao X, Jin L, ... ... Lo MC, et al. Structure-based design of novel inhibitors of the MDM2-p53 interaction. Journal of Medicinal Chemistry. 55: 4936-54. PMID 22524527 DOI: 10.1021/jm300354j  0.76
2012 Lo MC, Ngo R, Dai K, Li C, Liang L, Lee J, Emkey R, Eksterowicz J, Ventura M, Young SW, Xiao SH. Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors. Analytical Biochemistry. 421: 368-77. PMID 22056947 DOI: 10.1016/j.ab.2011.10.014  0.76
2010 Nowak P, Cole DC, Aulabaugh A, Bard J, Chopra R, Cowling R, Fan KY, Hu B, Jacobsen S, Jani M, Jin G, Lo MC, Malamas MS, Manas ES, Narasimhan R, et al. Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 632-5. PMID 19959359 DOI: 10.1016/j.bmcl.2009.11.052  0.76
2008 Lo MC, Wang M, Kim KW, Busby J, Yamane H, Zondlo J, Yuan C, Young SW, Xiao SH. A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase. Analytical Biochemistry. 376: 122-30. PMID 18294446 DOI: 10.1016/j.ab.2008.01.033  0.76
2004 Lo MC, Aulabaugh A, Krishnamurthy G, Kaplan J, Zask A, Smith RP, Ellestad G. Probing the interaction of HTI-286 with tubulin using a stilbene analogue. Journal of the American Chemical Society. 126: 9898-9. PMID 15303845 DOI: 10.1021/ja048619e  0.76
2004 Lo MC, Aulabaugh A, Jin G, Cowling R, Bard J, Malamas M, Ellestad G. Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Analytical Biochemistry. 332: 153-9. PMID 15301960 DOI: 10.1016/j.ab.2004.04.031  0.76
2003 Krishnamurthy G, Cheng W, Lo MC, Aulabaugh A, Razinkov V, Ding W, Loganzo F, Zask A, Ellestad G. Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules. Biochemistry. 42: 13484-95. PMID 14621994 DOI: 10.1021/bi035530x  0.76
2002 Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R. Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase. The Journal of Biological Chemistry. 277: 3698-707. PMID 11704676 DOI: 10.1074/jbc.M109670200  0.76
2001 Lo MC, Helm JS, Sarngadharan G, Pelczer I, Walker S. A new structure for the substrate-binding antibiotic ramoplanin. Journal of the American Chemical Society. 123: 8640-1. PMID 11525690 DOI: 10.1021/ja011080p  0.76
2001 Ye XY, Lo MC, Brunner L, Walker D, Kahne D, Walker S. Better substrates for bacterial transglycosylases. Journal of the American Chemical Society. 123: 3155-6. PMID 11457035 DOI: 10.1021/ja010028q  0.76
2000 Lo MC, Men H, Branstrom A, Helm J, Yao N, Goldman R, Walker S. A new mechanism of action proposed for ramoplanin [10] Journal of the American Chemical Society. 122: 3540-3541. DOI: 10.1021/ja000182x  0.76
1999 Ha S, Chang E, Lo MC, Men H, Park P, Ge M, Walker S. The kinetic characterization of Escherichia coli MurG using synthetic substrate analogues Journal of the American Chemical Society. 121: X. DOI: 10.1021/ja991556t  0.76
1999 Ha S, Chang E, Lo MC, Men H, Park P, Ge M, Walker S. The kinetic characterization of Escherichia coli MurG using synthetic substrate analogues Journal of the American Chemical Society. 121: X.  0.76
1998 Lo MC, Ha S, Pelczer I, Pal S, Walker S. The solution structure of the DNA-binding domain of Skn-1. Proceedings of the National Academy of Sciences of the United States of America. 95: 8455-60. PMID 9671699 DOI: 10.1073/pnas.95.15.8455  0.76
1997 Pal S, Lo MC, Schmidt D, Pelczer I, Thurber S, Walker S. Skn-1: evidence for a bipartite recognition helix in DNA binding. Proceedings of the National Academy of Sciences of the United States of America. 94: 5556-61. PMID 9159111 DOI: 10.1073/pnas.94.11.5556  0.76
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