David Toczyski - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hundley FV, Toczyski DP. Chemical-genetic CRISPR-Cas9 screens in human cells using a pathway-specific library. Star Protocols. 2: 100685. PMID 34382013 DOI: 10.1016/j.xpro.2021.100685  0.756
2021 Hundley FV, Sanvisens Delgado N, Marin HC, Carr KL, Tian R, Toczyski DP. A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis. Molecular Cell. PMID 33539788 DOI: 10.1016/j.molcel.2021.01.014  0.767
2020 Alme EB, Toczyski DP. Redundant targeting of Isr1 by two CDKs in mitotic cells. Current Genetics. PMID 33063175 DOI: 10.1007/s00294-020-01110-x  0.794
2020 Alme EB, Stevenson E, Krogan NJ, Swaney DL, Toczyski DP. The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. Plos Genetics. 16: e1008840. PMID 32579556 DOI: 10.1371/Journal.Pgen.1008840  0.794
2019 Sanvisens Delgado N, Toczyski DP. Mck1 kinase is a new player in the DNA damage checkpoint pathway. Plos Genetics. 15: e1008372. PMID 31671089 DOI: 10.1371/journal.pgen.1008372  0.343
2018 van Emden TS, Forn M, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer-Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A, Braun S. Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. Embo Reports. PMID 30420521 DOI: 10.15252/Embr.201847181  0.381
2018 Lao JP, Ulrich KM, Johnson JR, Newton BW, Vashisht AA, Wohlschlegel JA, Krogan NJ, Toczyski DP. The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1. G3 (Bethesda, Md.). PMID 30377154 DOI: 10.1534/G3.118.200767  0.479
2016 Mark KG, Loveless TB, Toczyski DP. Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps). Nature Protocols. 11: 291-301. PMID 26766115 DOI: 10.1038/Nprot.2016.008  0.781
2015 Meza-Gutierrez F, Hundley FV, Toczyski DP. Parallel Parkin: Cdc20 Takes a New Partner. Molecular Cell. 60: 3-4. PMID 26431023 DOI: 10.1016/j.molcel.2015.09.015  0.784
2015 Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP. Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 54: 4423-6. PMID 26161950 DOI: 10.1021/Acs.Biochem.5B00504  0.593
2015 Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. Plos Genetics. 11: e1005292. PMID 26091241 DOI: 10.1371/Journal.Pgen.1005292  0.82
2015 Edenberg ER, Mark KG, Toczyski DP. Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae. Plos Genetics. 11: e1005162. PMID 25894965 DOI: 10.1371/Journal.Pgen.1005162  0.828
2015 Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Molecular & Cellular Proteomics : McP. 14: 162-76. PMID 25381059 DOI: 10.1074/Mcp.M114.043141  0.591
2014 Edenberg ER, Downey M, Toczyski D. Polymerase stalling during replication, transcription and translation. Current Biology : Cb. 24: R445-52. PMID 24845677 DOI: 10.1016/J.Cub.2014.03.060  0.783
2014 Edenberg ER, Vashisht AA, Topacio BR, Wohlschlegel JA, Toczyski DP. Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proceedings of the National Academy of Sciences of the United States of America. 111: 5962-7. PMID 24715726 DOI: 10.1073/Pnas.1315325111  0.811
2014 Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski DP. Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. Molecular Cell. 53: 148-61. PMID 24389104 DOI: 10.1016/j.molcel.2013.12.003  0.613
2014 Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski DP. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Molecular and Cellular Biology. 34: 725-38. PMID 24324011 DOI: 10.1128/Mcb.01056-13  0.787
2013 Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Current Biology : Cb. 23: 1638-48. PMID 23973296 DOI: 10.1016/J.Cub.2013.06.050  0.606
2012 Landry BD, Doyle JP, Toczyski DP, Benanti JA. F-box protein specificity for g1 cyclins is dictated by subcellular localization. Plos Genetics. 8: e1002851. PMID 22844257 DOI: 10.1371/journal.pgen.1002851  0.761
2012 Foe IT, Toczyski DP. Ubiquitin ligases: Taming the APC. Nature Chemical Biology. 8: 323-4. PMID 22426190 DOI: 10.1038/Nchembio.923  0.779
2012 Berens TJ, Toczyski DP. Keeping it together in times of stress: checkpoint function at stalled replication forks. Molecular Cell. 45: 585-6. PMID 22405272 DOI: 10.1016/j.molcel.2012.02.011  0.333
2012 Berens TJ, Toczyski DP. Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Molecular Biology of the Cell. 23: 1058-67. PMID 22298423 DOI: 10.1091/mbc.E11-10-0852  0.412
2011 Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Current Biology : Cb. 21: 1870-7. PMID 22079111 DOI: 10.1016/J.Cub.2011.09.051  0.803
2011 Foe I, Toczyski D. Structural biology: a new look for the APC. Nature. 470: 182-3. PMID 21307929 DOI: 10.1038/470182A  0.764
2010 Lopez-Mosqueda J, Vidanes GM, Toczyski DP. Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle (Georgetown, Tex.). 9: 4266-8. PMID 20962588 DOI: 10.4161/Cc.9.21.13637  0.824
2010 Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski DP. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 467: 479-83. PMID 20865002 DOI: 10.1038/Nature09377  0.411
2010 Downey M, Edenberg ER, Toczyski DP. Repair scaffolding reaches new heights at blocked replication forks. Molecular Cell. 39: 162-4. PMID 20670884 DOI: 10.1016/J.Molcel.2010.07.007  0.793
2010 Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP. CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. Plos Biology. 8: e1000286. PMID 20126259 DOI: 10.1371/Journal.Pbio.1000286  0.832
2009 Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Molecular Cell. 33: 581-90. PMID 19285942 DOI: 10.1016/j.molcel.2009.01.032  0.726
2008 Benanti JA, Toczyski DP. Cdc20, an activator at last. Molecular Cell. 32: 460-1. PMID 19026776 DOI: 10.1016/j.molcel.2008.11.006  0.722
2008 Bonilla CY, Melo JA, Toczyski DP. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Molecular Cell. 30: 267-76. PMID 18471973 DOI: 10.1016/J.Molcel.2008.03.023  0.812
2007 Benanti JA, Cheung SK, Brady MC, Toczyski DP. A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nature Cell Biology. 9: 1184-91. PMID 17828247 DOI: 10.1038/ncb1639  0.749
2007 Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA. Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. Plos Genetics. 3: e105. PMID 17590086 DOI: 10.1371/Journal.Pgen.0030105  0.773
2007 Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, ... ... Toczyski DP, et al. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 446: 806-10. PMID 17314980 DOI: 10.1038/Nature05649  0.531
2006 Thornton BR, Toczyski DP. Precise destruction: an emerging picture of the APC. Genes & Development. 20: 3069-78. PMID 17114580 DOI: 10.1101/gad.1478306  0.581
2006 Miller KM, Maas NL, Toczyski DP. Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle (Georgetown, Tex.). 5: 2561-5. PMID 17106263  0.562
2006 Maas NL, Miller KM, DeFazio LG, Toczyski DP. Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Molecular Cell. 23: 109-19. PMID 16818235 DOI: 10.1016/j.molcel.2006.06.006  0.543
2006 Toczyski DP. Methods for studying adaptation to the DNA damage checkpoint in yeast. Methods in Enzymology. 409: 150-65. PMID 16793400 DOI: 10.1016/S0076-6879(05)09009-9  0.305
2006 Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. An architectural map of the anaphase-promoting complex. Genes & Development. 20: 449-60. PMID 16481473 DOI: 10.1101/gad.1396906  0.535
2005 Vidanes GM, Bonilla CY, Toczyski DP. Complicated tails: histone modifications and the DNA damage response. Cell. 121: 973-6. PMID 15989948 DOI: 10.1016/J.Cell.2005.06.013  0.791
2005 Garber PM, Vidanes GM, Toczyski DP. Damage in transition. Trends in Biochemical Sciences. 30: 63-6. PMID 15691649 DOI: 10.1016/J.Tibs.2004.12.004  0.82
2004 Kaye JA, Melo JA, Cheung SK, Vaze MB, Haber JE, Toczyski DP. DNA breaks promote genomic instability by impeding proper chromosome segregation Current Biology. 14: 2096-2106. PMID 15589151 DOI: 10.1016/J.Cub.2004.10.051  0.686
2004 Thornton BR, Chen KC, Cross FR, Tyson JJ, Toczyski DP. Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle (Georgetown, Tex.). 3: 629-33. PMID 15034296  0.51
2003 Thornton BR, Toczyski DP. Securin and B-cyclin/CDK are the only essential targets of the APC. Nature Cell Biology. 5: 1090-4. PMID 14634663 DOI: 10.1038/ncb1066  0.592
2002 Melo J, Toczyski D. A unified view of the DNA-damage checkpoint. Current Opinion in Cell Biology. 14: 237-45. PMID 11891124 DOI: 10.1016/S0955-0674(02)00312-5  0.745
2001 Melo JA, Cohen J, Toczyski DP. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes & Development. 15: 2809-21. PMID 11691833 DOI: 10.1101/Gad.903501  0.747
2001 Galgoczy DJ, Toczyski DP. Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Molecular and Cellular Biology. 21: 1710-8. PMID 11238908 DOI: 10.1128/Mcb.21.5.1710-1718.2001  0.371
1997 Toczyski DP, Galgoczy DJ, Hartwell LH. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 90: 1097-106. PMID 9323137 DOI: 10.1016/S0092-8674(00)80375-X  0.663
1997 Paulovich AG, Toczyski DP, Hartwell LH. When checkpoints fail. Cell. 88: 315-21. PMID 9039258 DOI: 10.1016/S0092-8674(00)81870-X  0.49
1994 Toczyski DP, Matera AG, Ward DC, Steitz JA. The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 91: 3463-7. PMID 8159770 DOI: 10.1073/Pnas.91.8.3463  0.618
1993 Toczyski DP, Steitz JA. The cellular RNA-binding protein EAP recognizes a conserved stem-loop in the Epstein-Barr virus small RNA EBER 1. Molecular and Cellular Biology. 13: 703-10. PMID 8380232 DOI: 10.1128/Mcb.13.1.703  0.445
1991 Toczyski DP, Steitz JA. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). The Embo Journal. 10: 459-66. PMID 1846807 DOI: 10.1002/J.1460-2075.1991.Tb07968.X  0.45
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