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Timothy A. Springer - Publications

Affiliations: 
Biological Chemistry & Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
Area:
Immunology
Website:
http://www.fas.harvard.edu/~biophys/Timothy_Springer.htm

280 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jiang Y, Fu H, Springer TA, Wong WP. Electrostatic Steering Enables Flow-Activated von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging. Journal of Molecular Biology. PMID 30797858 DOI: 10.1016/j.jmb.2019.02.014  0.52
2019 Dong X, Leksa NC, Chhabra ES, Arndt JW, Lu Q, Knockenhauer KE, Peters RT, Springer TA. The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. Blood. PMID 30642920 DOI: 10.1182/blood-2018-10-876300  0.6
2018 Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes DL, Shimaoka M, Springer TA, Dustin ML, Thrasher AJ, Burns SO. Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Wellcome Open Research. 3: 84. PMID 30483599 DOI: 10.12688/wellcomeopenres.14493.2  0.6
2018 Feng J, Dong X, Pinello J, Zhang J, Lu C, Iacob RE, Engen JR, Snell WJ, Springer TA. Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife. 7. PMID 30281023 DOI: 10.7554/eLife.39772  0.68
2018 Qin Y, Garrison BS, Ma W, Wang R, Jiang A, Li J, Mistry M, Bronson RT, Santoro D, Franco C, Robinton DA, Stevens B, Rossi DJ, Lu C, Springer TA. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell. PMID 29909984 DOI: 10.1016/j.cell.2018.05.027  0.68
2018 Sen M, Koksal AC, Yuki K, Wang J, Springer TA. Ligand and cation-induced structural alterations of the leukocyte integrin LFA-1. The Journal of Biological Chemistry. PMID 29507098 DOI: 10.1074/jbc.RA117.000710  1
2018 Dong X, Zhao B, Lin FY, Lu C, Rogers BN, Springer TA. High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378937 DOI: 10.1073/pnas.1718662115  0.68
2018 Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA. Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation. The Embo Journal. PMID 29343545 DOI: 10.15252/embj.201797931  0.6
2017 Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA. Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. Nature Communications. 8: 2047. PMID 29229906 DOI: 10.1038/s41467-017-01848-y  0.36
2017 Li J, Springer TA. Energy landscape differences among integrins establish the framework for understanding activation. The Journal of Cell Biology. PMID 29122968 DOI: 10.1083/jcb.201701169  0.64
2017 Zhao B, Xu S, Dong X, Lu C, Springer TA. Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1. The Journal of Biological Chemistry. PMID 29109152 DOI: 10.1074/jbc.M117.809657  0.68
2017 Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM. Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions. Proceedings of the National Academy of Sciences of the United States of America. 114: 10648-10653. PMID 29073038 DOI: 10.1073/pnas.1701136114  0.36
2017 Fu H, Jiang Y, Yang D, Scheiflinger F, Wong WP, Springer TA. Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. Nature Communications. 8: 324. PMID 28831047 DOI: 10.1038/s41467-017-00230-2  0.52
2017 Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI. Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Nature Communications. 8: 15408. PMID 28534487 DOI: 10.1038/ncomms15408  0.6
2017 Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA. Atypical interactions of integrin αVβ8 with pro-TGF-β1. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484027 DOI: 10.1073/pnas.1705129114  0.68
2017 Li J, Springer TA. Integrin extension enables ultrasensitive regulation by cytoskeletal force. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416675 DOI: 10.1073/pnas.1704171114  0.64
2017 Xu S, Wang J, Wang JH, Springer TA. Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2. Proceedings of the National Academy of Sciences of the United States of America. PMID 28292891 DOI: 10.1073/pnas.1620881114  0.6
2017 Gansner JM, Leung AD, Superdock M, Blair MC, Ammerman MB, Durand EM, Barut B, Handin RI, Stachura DL, Lu C, Springer TA, Zon LI. Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood. PMID 28126924 DOI: 10.1182/blood-2016-12-759993  0.68
2017 Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Conformational equilibria and intrinsic affinities define integrin activation. The Embo Journal. PMID 28122868 DOI: 10.15252/embj.201695803  0.68
2017 Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA. Force interacts with macromolecular structure in activation of TGF-β. Nature. PMID 28117447 DOI: 10.1038/nature21035  0.68
2016 Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Relating conformation to function in integrin α5β1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27317747 DOI: 10.1073/pnas.1605074113  0.68
2016 Springer TA, Sen M. Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops. Proceedings of the National Academy of Sciences of the United States of America. PMID 26936951 DOI: 10.1073/pnas.1601379113  1
2015 Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA. β-subunit Binding is Sufficient for Ligands to open the Integrin αIIbβ3 Headpiece. The Journal of Biological Chemistry. PMID 26631735 DOI: 10.1074/jbc.M115.705624  1
2015 Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE, Gresele P. Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in Glanzmann variants. Haematologica. PMID 26452979 DOI: 10.3324/haematol.2015.130849  1
2015 Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K. Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13. Journal of Thrombosis and Haemostasis : Jth. 13: 2063-75. PMID 26391536 DOI: 10.1111/jth.13149  1
2015 Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA. Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3. Blood. 126: 2138-45. PMID 26282540 DOI: 10.1182/blood-2015-04-639351  1
2015 Yakovenko O, Tchesnokova V, Sokurenko EV, Thomas WE. Inactive conformation enhances binding function in physiological conditions. Proceedings of the National Academy of Sciences of the United States of America. 112: 9884-9. PMID 26216967 DOI: 10.1073/pnas.1503160112  1
2015 Kim J, Hudson NE, Springer TA. Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases. Proceedings of the National Academy of Sciences of the United States of America. 112: 4648-53. PMID 25810255 DOI: 10.1073/pnas.1501689112  1
2015 Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X. Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology. 10: 465-71. PMID 25775150 DOI: 10.1038/nnano.2015.28  0.64
2015 Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA. Structure of bone morphogenetic protein 9 procomplex. Proceedings of the National Academy of Sciences of the United States of America. 112: 3710-5. PMID 25751889 DOI: 10.1073/pnas.1501303112  1
2014 Xia W, Springer TA. Metal ion and ligand binding of integrin α5β1. Proceedings of the National Academy of Sciences of the United States of America. 111: 17863-8. PMID 25475857 DOI: 10.1073/pnas.1420645111  1
2014 Dong X, Hudson NE, Lu C, Springer TA. Structural determinants of integrin β-subunit specificity for latent TGF-β. Nature Structural & Molecular Biology. 21: 1091-6. PMID 25383667 DOI: 10.1038/nsmb.2905  1
2014 Springer TA. von Willebrand factor, Jedi knight of the bloodstream. Blood. 124: 1412-25. PMID 24928861 DOI: 10.1182/blood-2014-05-378638  1
2014 Song G, Springer TA. Structures of the Toxoplasma gliding motility adhesin. Proceedings of the National Academy of Sciences of the United States of America. 111: 4862-7. PMID 24639528 DOI: 10.1073/pnas.1403059111  1
2014 Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorganic & Medicinal Chemistry. 22: 2353-65. PMID 24593905 DOI: 10.1016/j.bmc.2014.01.050  1
2014 Zhou YF, Springer TA. Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. Blood. 123: 1785-93. PMID 24394662 DOI: 10.1182/blood-2013-11-523639  1
2014 Blenner MA, Dong X, Springer TA. Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib. The Journal of Biological Chemistry. 289: 5565-79. PMID 24391089 DOI: 10.1074/jbc.M113.511220  1
2013 Sen M, Yuki K, Springer TA. An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2. The Journal of Cell Biology. 203: 629-42. PMID 24385486 DOI: 10.1083/jcb.201308083  1
2013 Yu Y, Schürpf T, Springer TA. How natalizumab binds and antagonizes α4 integrins. The Journal of Biological Chemistry. 288: 32314-25. PMID 24047894 DOI: 10.1074/jbc.M113.501668  1
2013 Zhu J, Zhu J, Springer TA. Complete integrin headpiece opening in eight steps. The Journal of Cell Biology. 201: 1053-68. PMID 23798730 DOI: 10.1083/jcb.201212037  1
2013 Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. The Journal of Cell Biology. 201: 449-65. PMID 23629967 DOI: 10.1083/jcb.201209077  1
2013 Xu AJ, Springer TA. Mechanisms by which von Willebrand disease mutations destabilize the A2 domain. The Journal of Biological Chemistry. 288: 6317-24. PMID 23322777 DOI: 10.1074/jbc.M112.422618  1
2013 Yu Y, Zhu J, Huang PS, Wang JH, Pullen N, Springer TA. Domain 1 of mucosal addressin cell adhesion molecule has an I1-set fold and a flexible integrin-binding loop. The Journal of Biological Chemistry. 288: 6284-94. PMID 23297416 DOI: 10.1074/jbc.M112.413153  1
2012 Song G, Koksal AC, Lu C, Springer TA. Shape change in the receptor for gliding motility in Plasmodium sporozoites. Proceedings of the National Academy of Sciences of the United States of America. 109: 21420-5. PMID 23236185 DOI: 10.1073/pnas.1218581109  1
2012 Dong X, Mi LZ, Zhu J, Wang W, Hu P, Luo BH, Springer TA. α(V)β(3) integrin crystal structures and their functional implications. Biochemistry. 51: 8814-28. PMID 23106217 DOI: 10.1021/bi300734n  1
2012 Lu C, Mi LZ, Schürpf T, Walz T, Springer TA. Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor. The Journal of Biological Chemistry. 287: 38244-53. PMID 22988250 DOI: 10.1074/jbc.M112.414391  1
2012 Kang S, Kim CU, Gu X, Owens RM, van Rijn SJ, Boonyaleepun V, Mao Y, Springer TA, Jin MM. Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1. Plos One. 7: e44124. PMID 22956999 DOI: 10.1371/journal.pone.0044124  1
2012 Schürpf T, Chen Q, Liu JH, Wang R, Springer TA, Wang JH. The RGD finger of Del-1 is a unique structural feature critical for integrin binding. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3412-20. PMID 22601780 DOI: 10.1096/fj.11-202036  1
2012 Doud MB, Koksal AC, Mi LZ, Song G, Lu C, Springer TA. Unexpected fold in the circumsporozoite protein target of malaria vaccines. Proceedings of the National Academy of Sciences of the United States of America. 109: 7817-22. PMID 22547819 DOI: 10.1073/pnas.1205737109  1
2012 Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA. Sequence and structure relationships within von Willebrand factor. Blood. 120: 449-58. PMID 22490677 DOI: 10.1182/blood-2012-01-405134  1
2012 Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 3686-99. PMID 22442443 DOI: 10.4049/jimmunol.1102594  1
2012 Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, et al. Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Science Translational Medicine. 4: 125ra32. PMID 22422993 DOI: 10.1126/scitranslmed.3003576  1
2012 Chen X, Yu Y, Mi LZ, Walz T, Springer TA. Molecular basis for complement recognition by integrin αXβ2. Proceedings of the National Academy of Sciences of the United States of America. 109: 4586-91. PMID 22393018 DOI: 10.1073/pnas.1202051109  1
2012 Xu AJ, Springer TA. Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding. Proceedings of the National Academy of Sciences of the United States of America. 109: 3742-7. PMID 22357761 DOI: 10.1073/pnas.1121261109  1
2012 Wang R, Zhu J, Dong X, Shi M, Lu C, Springer TA. GARP regulates the bioavailability and activation of TGFβ. Molecular Biology of the Cell. 23: 1129-39. PMID 22278742 DOI: 10.1091/mbc.E11-12-1018  1
2012 Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA. Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. The Journal of Cell Biology. 196: 131-46. PMID 22232704 DOI: 10.1083/jcb.201110023  1
2012 Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. Current Opinion in Cell Biology. 24: 107-15. PMID 22129583 DOI: 10.1016/j.ceb.2011.10.004  1
2011 Weitz-Schmidt G, Schürpf T, Springer TA. The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins. The Journal of Biological Chemistry. 286: 42115-22. PMID 21965670 DOI: 10.1074/jbc.M111.282830  1
2011 Schürpf T, Springer TA. Regulation of integrin affinity on cell surfaces. The Embo Journal. 30: 4712-27. PMID 21946563 DOI: 10.1038/emboj.2011.333  1
2011 Zhou YF, Eng ET, Nishida N, Lu C, Walz T, Springer TA. A pH-regulated dimeric bouquet in the structure of von Willebrand factor. The Embo Journal. 30: 4098-111. PMID 21857647 DOI: 10.1038/emboj.2011.297  1
2011 Eng ET, Smagghe BJ, Walz T, Springer TA. Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy. The Journal of Biological Chemistry. 286: 35218-26. PMID 21832081 DOI: 10.1074/jbc.M111.275107  1
2011 Mi LZ, Lu C, Li Z, Nishida N, Walz T, Springer TA. Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor. Nature Structural & Molecular Biology. 18: 984-9. PMID 21822280 DOI: 10.1038/nsmb.2092  1
2011 Springer TA. Biology and physics of von Willebrand factor concatamers. Journal of Thrombosis and Haemostasis : Jth. 9: 130-43. PMID 21781248 DOI: 10.1111/j.1538-7836.2011.04320.x  1
2011 Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. Latent TGF-β structure and activation. Nature. 474: 343-9. PMID 21677751 DOI: 10.1038/nature10152  1
2011 Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. Journal of Immunology (Baltimore, Md. : 1950). 186: 5034-8. PMID 21505215  1
2011 Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. Journal of Immunology (Baltimore, Md. : 1950). 186: 5024-33. PMID 21505214  1
2011 Zhou M, Dong X, Baldauf C, Chen H, Zhou Y, Springer TA, Luo X, Zhong C, Gräter F, Ding J. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13. Blood. 117: 4623-31. PMID 21385852 DOI: 10.1182/blood-2010-11-321596  1
2011 Wang W, Zhu J, Springer TA, Luo BH. Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling. The Journal of Biological Chemistry. 286: 1860-7. PMID 21081497 DOI: 10.1074/jbc.M110.193797  1
2010 Pan Y, Zhang K, Qi J, Yue J, Springer TA, Chen J. Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7. Proceedings of the National Academy of Sciences of the United States of America. 107: 21388-93. PMID 21098296 DOI: 10.1073/pnas.1015487107  1
2010 Lu C, Mi LZ, Grey MJ, Zhu J, Graef E, Yokoyama S, Springer TA. Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. Molecular and Cellular Biology. 30: 5432-43. PMID 20837704 DOI: 10.1128/MCB.00742-10  1
2010 Kim J, Zhang CZ, Zhang X, Springer TA. A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature. 466: 992-5. PMID 20725043 DOI: 10.1038/nature09295  1
2010 Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA. Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood. 116: 5050-9. PMID 20679525 DOI: 10.1182/blood-2010-04-281154  1
2010 Chen X, Xie C, Nishida N, Li Z, Walz T, Springer TA. Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proceedings of the National Academy of Sciences of the United States of America. 107: 14727-32. PMID 20679211 DOI: 10.1073/pnas.1008663107  1
2010 Smagghe BJ, Huang PS, Ban YE, Baker D, Springer TA. Modulation of integrin activation by an entropic spring in the {beta}-knee. The Journal of Biological Chemistry. 285: 32954-66. PMID 20670939 DOI: 10.1074/jbc.M110.145177  1
2010 Owens RM, Gu X, Shin M, Springer TA, Jin MM. Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. The Journal of Biological Chemistry. 285: 15906-15. PMID 20304924 DOI: 10.1074/jbc.M110.104349  1
2010 Xie C, Zhu J, Chen X, Mi L, Nishida N, Springer TA. Structure of an integrin with an alphaI domain, complement receptor type 4. The Embo Journal. 29: 666-79. PMID 20033057 DOI: 10.1038/emboj.2009.367  1
2009 Zhang H, Liu JH, Yang W, Springer T, Shimaoka M, Wang JH. Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proceedings of the National Academy of Sciences of the United States of America. 106: 18345-50. PMID 19805116 DOI: 10.1073/pnas.0909301106  1
2009 Zhang X, Halvorsen K, Zhang CZ, Wong WP, Springer TA. Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science (New York, N.Y.). 324: 1330-4. PMID 19498171 DOI: 10.1126/science.1170905  1
2009 Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA. Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proceedings of the National Academy of Sciences of the United States of America. 106: 9226-31. PMID 19470641 DOI: 10.1073/pnas.0903679106  1
2009 Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA. The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. Molecular Cell. 34: 234-49. PMID 19394300 DOI: 10.1016/j.molcel.2009.02.022  1
2009 Vanhoorelbeke K, De Meyer SF, Pareyn I, Melchior C, Plançon S, Margue C, Pradier O, Fondu P, Kieffer N, Springer TA, Deckmyn H. The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation. The Journal of Biological Chemistry. 284: 14914-20. PMID 19329429 DOI: 10.1074/jbc.M809167200  1
2009 Waldron TT, Springer TA. Transmission of allostery through the lectin domain in selectin-mediated cell adhesion. Proceedings of the National Academy of Sciences of the United States of America. 106: 85-90. PMID 19118202 DOI: 10.1073/pnas.0810620105  1
2009 Springer TA. Structural basis for selectin mechanochemistry. Proceedings of the National Academy of Sciences of the United States of America. 106: 91-6. PMID 19118197 DOI: 10.1073/pnas.0810784105  1
2009 Luo BH, Karanicolas J, Harmacek LD, Baker D, Springer TA. Rationally designed integrin beta3 mutants stabilized in the high affinity conformation. The Journal of Biological Chemistry. 284: 3917-24. PMID 19019827 DOI: 10.1074/jbc.M806312200  1
2009 Zhang CZ, Seog J, Dill J, Smith SB, Zhang FX, Cecconi C, Marqusee S, Bustamante C, Springer TA. What can we learn from mechanical unfolding of a single protein domain by optical tweezers Aiche Annual Meeting, Conference Proceedings 1
2009 Schönemann E, Springer TA, Otten M, Becker M. Where is GIOVE-A exactly? Gps World. 20: 42-50+41.  0.36
2008 Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Molecular Cell. 32: 849-61. PMID 19111664 DOI: 10.1016/j.molcel.2008.11.018  1
2008 Mi LZ, Grey MJ, Nishida N, Walz T, Lu C, Springer TA. Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs. Biochemistry. 47: 10314-23. PMID 18771282 DOI: 10.1021/bi801006s  1
2008 Springer TA, Zhu J, Xiao T. Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 182: 791-800. PMID 18710925 DOI: 10.1083/jcb.200801146  1
2008 Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, Springer TA, Wang JH. An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Molecular Cell. 31: 432-7. PMID 18691975 DOI: 10.1016/j.molcel.2008.06.022  1
2008 Carman CV, Springer TA. Trans-cellular migration: cell-cell contacts get intimate. Current Opinion in Cell Biology. 20: 533-40. PMID 18595683 DOI: 10.1016/j.ceb.2008.05.007  1
2008 Morin NA, Oakes PW, Hyun YM, Lee D, Chin YE, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. The Journal of Experimental Medicine. 205: 195-205. PMID 18195072 DOI: 10.1084/jem.20071543  1
2008 Morin NA, Oakes PW, Hyun YM, Lee D, Chin YE, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration (Journal of Experimental Medicine (2008) 205, 1 (195-205)) Journal of Experimental Medicine. 205: 993. DOI: 10.1084/jem.20071543032708c  1
2008 Milstein C, Galfre G, Secher DS, Springer T. Monoclonal Antibodies and Cell Surface Antigens Human Genetics: Possibilities and Realities. 251-281. DOI: 10.1002/9780470720486.ch11  1
2007 Chen X, Kim TD, Carman CV, Mi LZ, Song G, Springer TA. Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. Proceedings of the National Academy of Sciences of the United States of America. 104: 15358-63. PMID 17881562 DOI: 10.1073/pnas.0707406104  1
2007 Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proceedings of the National Academy of Sciences of the United States of America. 104: 14753-8. PMID 17785425 DOI: 10.1073/pnas.0705201104  1
2007 Vorup-Jensen T, Waldron TT, Astrof N, Shimaoka M, Springer TA. The connection between metal ion affinity and ligand affinity in integrin I domains. Biochimica Et Biophysica Acta. 1774: 1148-55. PMID 17702677 DOI: 10.1016/j.bbapap.2007.06.014  1
2007 Vorup-Jensen T, Chi L, Gjelstrup LC, Jensen UB, Jewett CA, Xie C, Shimaoka M, Linhardt RJ, Springer TA. Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin. The Journal of Biological Chemistry. 282: 30869-77. PMID 17699512 DOI: 10.1074/jbc.M706114200  1
2007 Zhu J, Carman CV, Kim M, Shimaoka M, Springer TA, Luo BH. Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. Blood. 110: 2475-83. PMID 17615290 DOI: 10.1182/blood-2007-03-080077  1
2007 Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 26: 784-97. PMID 17570692 DOI: 10.1016/j.immuni.2007.04.015  1
2007 Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA. Tests of the extension and deadbolt models of integrin activation. The Journal of Biological Chemistry. 282: 11914-20. PMID 17301049 DOI: 10.1074/jbc.M700249200  1
2007 Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annual Review of Immunology. 25: 619-47. PMID 17201681 DOI: 10.1146/annurev.immunol.25.022106.141618  1
2006 Nishida N, Walz T, Springer TA. Structural transitions of complement component C3 and its activation products. Proceedings of the National Academy of Sciences of the United States of America. 103: 19737-42. PMID 17172439 DOI: 10.1073/pnas.0609791104  1
2006 Astrof NS, Salas A, Shimaoka M, Chen J, Springer TA. Importance of force linkage in mechanochemistry of adhesion receptors. Biochemistry. 45: 15020-8. PMID 17154539 DOI: 10.1021/bi061566o  1
2006 Springer TA. Complement and the multifaceted functions of VWA and integrin I domains. Structure (London, England : 1993). 14: 1611-6. PMID 17098186 DOI: 10.1016/j.str.2006.10.001  1
2006 Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity. 25: 583-94. PMID 17045822 DOI: 10.1016/j.immuni.2006.07.016  1
2006 Swers JS, Widom A, Phan U, Springer TA, Wittrup KD. A high affinity human antibody antagonist of P-selectin mediated rolling. Biochemical and Biophysical Research Communications. 350: 508-13. PMID 17027652 DOI: 10.1016/j.bbrc.2006.08.197  1
2006 Yang W, Carman CV, Kim M, Salas A, Shimaoka M, Springer TA. A small molecule agonist of an integrin, alphaLbeta2. The Journal of Biological Chemistry. 281: 37904-12. PMID 17023419 DOI: 10.1074/jbc.M606888200  1
2006 Shimaoka M, Kim M, Cohen EH, Yang W, Astrof N, Peer D, Salas A, Ferrand A, Springer TA. AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 13991-6. PMID 16963559 DOI: 10.1073/pnas.0605716103  1
2006 Chen J, Yang W, Kim M, Carman CV, Springer TA. Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. Proceedings of the National Academy of Sciences of the United States of America. 103: 13062-7. PMID 16920795 DOI: 10.1073/pnas.0605666103  1
2006 Luo BH, Springer TA. Integrin structures and conformational signaling. Current Opinion in Cell Biology. 18: 579-86. PMID 16904883 DOI: 10.1016/j.ceb.2006.08.005  1
2006 Huang L, Shimaoka M, Rondon IJ, Roy I, Chang Q, Po M, Dransfield DT, Ladner RC, Edge AS, Salas A, Wood CR, Springer TA, Cohen EH. Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1. Journal of Leukocyte Biology. 80: 905-14. PMID 16888085 DOI: 10.1189/jlb.1105649  1
2006 Phan UT, Waldron TT, Springer TA. Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nature Immunology. 7: 883-9. PMID 16845394 DOI: 10.1038/ni1366  1
2006 Jin M, Song G, Carman CV, Kim YS, Astrof NS, Shimaoka M, Wittrup DK, Springer TA. Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proceedings of the National Academy of Sciences of the United States of America. 103: 5758-63. PMID 16595626 DOI: 10.1073/pnas.0601164103  1
2006 Salas A, Shimaoka M, Phan U, Kim M, Springer TA. Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state. The Journal of Biological Chemistry. 281: 10876-82. PMID 16505487 DOI: 10.1074/jbc.M512472200  1
2006 Song G, Lazar GA, Kortemme T, Shimaoka M, Desjarlais JR, Baker D, Springer TA. Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion. The Journal of Biological Chemistry. 281: 5042-9. PMID 16354667 DOI: 10.1074/jbc.M510454200  1
2005 Zhang F, Marcus WD, Goyal NH, Selvaraj P, Springer TA, Zhu C. Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain. The Journal of Biological Chemistry. 280: 42207-18. PMID 16234238 DOI: 10.1074/jbc.M510407200  1
2005 Luo BH, Carman CV, Takagi J, Springer TA. Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proceedings of the National Academy of Sciences of the United States of America. 102: 3679-84. PMID 15738420 DOI: 10.1073/pnas.0409440102  1
2005 Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, Springer TA, Wang JH. An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proceedings of the National Academy of Sciences of the United States of America. 102: 3366-71. PMID 15728350 DOI: 10.1073/pnas.0500200102  1
2005 Vorup-Jensen T, Carman CV, Shimaoka M, Schuck P, Svitel J, Springer TA. Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2. Proceedings of the National Academy of Sciences of the United States of America. 102: 1614-9. PMID 15665082 DOI: 10.1073/pnas.0409057102  1
2005 Jiménez D, Roda-Navarro P, Springer TA, Casasnovas JM. Contribution of N-linked glycans to the conformation and function of intercellular adhesion molecules (ICAMs). The Journal of Biological Chemistry. 280: 5854-61. PMID 15545280 DOI: 10.1074/jbc.M412104200  1
2004 Kim M, Carman CV, Yang W, Salas A, Springer TA. The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2. The Journal of Cell Biology. 167: 1241-53. PMID 15611342 DOI: 10.1083/jcb.200404160  1
2004 Jin M, Andricioaei I, Springer TA. Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure (London, England : 1993). 12: 2137-47. PMID 15576028 DOI: 10.1016/j.str.2004.10.005  1
2004 Shimaoka M, Springer TA. Therapeutic antagonists and the conformational regulation of the beta2 integrins. Current Topics in Medicinal Chemistry. 4: 1485-95. PMID 15544539 DOI: 10.2174/1568026043387575  1
2004 Carman CV, Springer TA. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. The Journal of Cell Biology. 167: 377-88. PMID 15504916 DOI: 10.1083/jcb.200404129  1
2004 Springer TA, Wang JH. The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Advances in Protein Chemistry. 68: 29-63. PMID 15500858 DOI: 10.1016/S0065-3233(04)68002-8  1
2004 Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA. The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 15422-7. PMID 15494438 DOI: 10.1073/pnas.0406680101  1
2004 Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Developmental Cell. 7: 585-95. PMID 15469846 DOI: 10.1016/j.devcel.2004.07.021  1
2004 Chen J, Takagi J, Xie C, Xiao T, Luo BH, Springer TA. The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7. The Journal of Biological Chemistry. 279: 55556-61. PMID 15448154 DOI: 10.1074/jbc.M407773200  1
2004 Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature. 432: 59-67. PMID 15378069 DOI: 10.1038/nature02976  1
2004 Lu C, Shimaoka M, Salas A, Springer TA. The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1. Journal of Immunology (Baltimore, Md. : 1950). 173: 3972-8. PMID 15356146  1
2004 Artoni A, Li J, Mitchell B, Ruan J, Takagi J, Springer TA, French DL, Coller BS. Integrin beta3 regions controlling binding of murine mAb 7E3: implications for the mechanism of integrin alphaIIbbeta3 activation. Proceedings of the National Academy of Sciences of the United States of America. 101: 13114-20. PMID 15277669 DOI: 10.1073/pnas.0404201101  1
2004 Luo BH, Springer TA, Takagi J. A specific interface between integrin transmembrane helices and affinity for ligand. Plos Biology. 2: e153. PMID 15208712 DOI: 10.1371/journal.pbio.0020153  1
2004 Luo BH, Strokovich K, Walz T, Springer TA, Takagi J. Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain. The Journal of Biological Chemistry. 279: 27466-71. PMID 15123676 DOI: 10.1074/jbc.M404354200  1
2004 Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH. Structural basis for dimerization of ICAM-1 on the cell surface. Molecular Cell. 14: 269-76. PMID 15099525 DOI: 10.1016/S1097-2765(04)00204-7  1
2004 Salas A, Shimaoka M, Kogan AN, Harwood C, von Andrian UH, Springer TA. Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction. Immunity. 20: 393-406. PMID 15084269 DOI: 10.1016/S1074-7613(04)00082-2  1
2004 Culi J, Springer TA, Mann RS. Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. The Embo Journal. 23: 1372-80. PMID 15014448 DOI: 10.1038/sj.emboj.7600132  1
2004 Yang W, Shimaoka M, Chen J, Springer TA. Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions. Proceedings of the National Academy of Sciences of the United States of America. 101: 2333-8. PMID 14983010 DOI: 10.1073/pnas.0307291101  1
2004 Yang W, Shimaoka M, Salas A, Takagi J, Springer TA. Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proceedings of the National Academy of Sciences of the United States of America. 101: 2906-11. PMID 14978279 DOI: 10.1073/pnas.0307340101  1
2004 Luo BH, Takagi J, Springer TA. Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. The Journal of Biological Chemistry. 279: 10215-21. PMID 14681220 DOI: 10.1074/jbc.M312732200  1
2003 Carman CV, Jun CD, Salas A, Springer TA. Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. Journal of Immunology (Baltimore, Md. : 1950). 171: 6135-44. PMID 14634129  1
2003 Chen J, Salas A, Springer TA. Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nature Structural Biology. 10: 995-1001. PMID 14608374 DOI: 10.1038/nsb1011  1
2003 Carman CV, Springer TA. Integrin avidity regulation: are changes in affinity and conformation underemphasized? Current Opinion in Cell Biology. 15: 547-56. PMID 14519389 DOI: 10.1016/j.ceb.2003.08.003  1
2003 Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science (New York, N.Y.). 301: 1720-5. PMID 14500982 DOI: 10.1126/science.1084174  1
2003 Shimaoka M, Salas A, Yang W, Weitz-Schmidt G, Springer TA. Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other. Immunity. 19: 391-402. PMID 14499114 DOI: 10.1016/S1074-7613(03)00238-3  1
2003 Takagi J, Strokovich K, Springer TA, Walz T. Structure of integrin alpha5beta1 in complex with fibronectin. The Embo Journal. 22: 4607-15. PMID 12970173 DOI: 10.1093/emboj/cdg445  1
2003 Shimaoka M, Springer TA. Therapeutic antagonists and conformational regulation of integrin function. Nature Reviews. Drug Discovery. 2: 703-16. PMID 12951577 DOI: 10.1038/nrd1174  1
2003 Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface. Nature. 424: 969-74. PMID 12931195 DOI: 10.1038/nature01873  1
2003 Tohyama Y, Katagiri K, Pardi R, Lu C, Springer TA, Kinashi T. The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration. Molecular Biology of the Cell. 14: 2570-82. PMID 12808052 DOI: 10.1091/mbc.E02-09-0615  1
2003 Luo BH, Springer TA, Takagi J. Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand. Proceedings of the National Academy of Sciences of the United States of America. 100: 2403-8. PMID 12604783 DOI: 10.1073/pnas.0438060100  1
2003 Luo BH, Springer TA, Takagi J. High affinity ligand binding by integrins does not involve head separation. The Journal of Biological Chemistry. 278: 17185-9. PMID 12600996 DOI: 10.1074/jbc.M301516200  1
2003 Vorup-Jensen T, Ostermeier C, Shimaoka M, Hommel U, Springer TA. Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proceedings of the National Academy of Sciences of the United States of America. 100: 1873-8. PMID 12554829 DOI: 10.1073/pnas.0237387100  1
2003 Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell. 112: 99-111. PMID 12526797 DOI: 10.1016/S0092-8674(02)01257-6  1
2002 Springer TA. Predicted and experimental structures of integrins and beta-propellers. Current Opinion in Structural Biology. 12: 802-13. PMID 12504686 DOI: 10.1016/S0959-440X(02)00384-6  1
2002 Shimaoka M, Lu C, Salas A, Xiao T, Takagi J, Springer TA. Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proceedings of the National Academy of Sciences of the United States of America. 99: 16737-41. PMID 12466503 DOI: 10.1073/pnas.252633099  1
2002 Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA. Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins. Structure (London, England : 1993). 10: 1453-64. PMID 12377130 DOI: 10.1016/S0969-2126(02)00840-7  1
2002 Springer TA, Chen S, Alon R. Measurement of selectin tether bond lifetimes. Biophysical Journal. 83: 2318-20; author repl. PMID 12371417 DOI: 10.1016/S0006-3495(02)73991-X  1
2002 Takagi J, Springer TA. Integrin activation and structural rearrangement. Immunological Reviews. 186: 141-63. PMID 12234369 DOI: 10.1034/j.1600-065X.2002.18613.x  1
2002 Takagi J, Petre BM, Walz T, Springer TA. Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell. 110: 599-11. PMID 12230977 DOI: 10.1016/S0092-8674(02)00935-2  1
2002 Hirose J, Kawashima H, Swope Willis M, Springer TA, Hasegawa H, Yoshie O, Miyasaka M. Chondroitin sulfate B exerts its inhibitory effect on secondary lymphoid tissue chemokine (SLC) by binding to the C-terminus of SLC. Biochimica Et Biophysica Acta. 1571: 219-24. PMID 12090936 DOI: 10.1016/S0304-4165(02)00232-5  1
2002 Springer TA. César Milstein, the father of modern immunology. Nature Immunology. 3: 501-3. PMID 12032559 DOI: 10.1038/ni0602-501  1
2002 Springer TA. Immunology. Retrospective: César Milstein (1927-2002). Science (New York, N.Y.). 296: 1253. PMID 12016298 DOI: 10.1126/science.1073325  1
2002 Shimaoka M, Takagi J, Springer TA. Conformational regulation of integrin structure and function. Annual Review of Biophysics and Biomolecular Structure. 31: 485-516. PMID 11988479 DOI: 10.1146/annurev.biophys.31.101101.140922  1
2002 Takagi J, DeBottis DP, Erickson HP, Springer TA. The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. Biochemistry. 41: 4339-47. PMID 11914080 DOI: 10.1021/bi016047u  1
2002 Beglova N, Blacklow SC, Takagi J, Springer TA. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nature Structural Biology. 9: 282-7. PMID 11896403 DOI: 10.1038/nsb779  1
2002 Ueno T, Hara K, Willis MS, Malin MA, Höpken UE, Gray DH, Matsushima K, Lipp M, Springer TA, Boyd RL, Yoshie O, Takahama Y. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity. 16: 205-18. PMID 11869682 DOI: 10.1016/S1074-7613(02)00267-4  1
2002 Ma Q, Shimaoka M, Lu C, Jing H, Carman CV, Springer TA. Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. The Journal of Biological Chemistry. 277: 10638-41. PMID 11792712 DOI: 10.1074/jbc.M112417200  1
2002 Chang DD, Hoang BQ, Liu J, Springer TA. Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin. The Journal of Biological Chemistry. 277: 8140-5. PMID 11741908 DOI: 10.1074/jbc.M109031200  1
2002 Bock H, Hugentobler U, Springer TA, Beutler G. Efficient precise orbit determination of LEO satellites using GPS Advances in Space Research. 30: 295-300. DOI: 10.1016/S0273-1177(02)00298-3  0.36
2002 Springer TA, Shimaoka M, Lu C, Xiao T, Carman C, Salas A, Wang JH, Liu JH, Yang Y, Blacklow S, Beglova N, Takagi J. Conformational activation of 2 integrins, their I domains, and regulation by small molecule antagonists Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 730-731.  1
2001 Springer TA. Immunoaffinity chromatography. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 8.2. PMID 18432857 DOI: 10.1002/0471142735.im0802s18  1
2001 Springer TA. Immunoaffinity chromatography. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 9.5. PMID 18429214 DOI: 10.1002/0471140864.ps0905s03  1
2001 Springer TA. Immunoaffinity chromatography. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 5.11. PMID 18428494 DOI: 10.1002/0471142301.ns0511s05  1
2001 Springer TA. Immunoaffinity chromatography. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 10.11A. PMID 18265050 DOI: 10.1002/0471142727.mb1011as36  1
2001 de Château M, Chen S, Salas A, Springer TA. Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction. Biochemistry. 40: 13972-9. PMID 11705388 DOI: 10.1021/bi011582f  1
2001 Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proceedings of the National Academy of Sciences of the United States of America. 98: 11175-80. PMID 11572973 DOI: 10.1073/pnas.201420198  1
2001 Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, Springer TA, Fan X, Shen H, Lieberman J, von Andrian UH. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. The Journal of Clinical Investigation. 108: 871-8. PMID 11560956 DOI: 10.1172/JCI13296  1
2001 Kamata T, Tieu KK, Irie A, Springer TA, Takada Y. Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model. The Journal of Biological Chemistry. 276: 44275-83. PMID 11557768 DOI: 10.1074/jbc.M107021200  1
2001 Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. Journal of Immunology (Baltimore, Md. : 1950). 167: 366-74. PMID 11418672  1
2001 Jun CD, Shimaoka M, Carman CV, Takagi J, Springer TA. Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion. Proceedings of the National Academy of Sciences of the United States of America. 98: 6830-5. PMID 11391003 DOI: 10.1073/pnas.121186998  1
2001 Jun CD, Carman CV, Redick SD, Shimaoka M, Erickson HP, Springer TA. Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). The Journal of Biological Chemistry. 276: 29019-27. PMID 11390397 DOI: 10.1074/jbc.M103394200  1
2001 Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nature Structural Biology. 8: 499-504. PMID 11373616 DOI: 10.1038/88556  1
2001 Shimaoka M, Lu C, Palframan RT, von Andrian UH, McCormack A, Takagi J, Springer TA. Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 98: 6009-14. PMID 11353828 DOI: 10.1073/pnas.101130498  1
2001 Takagi J, Erickson HP, Springer TA. C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. Nature Structural Biology. 8: 412-6. PMID 11323715 DOI: 10.1038/87569  1
2001 Fedyk ER, Jones D, Critchley HO, Phipps RP, Blieden TM, Springer TA. Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. Journal of Immunology (Baltimore, Md. : 1950). 166: 5749-54. PMID 11313418  1
2001 Lu C, Ferzly M, Takagi J, Springer TA. Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation. Journal of Immunology (Baltimore, Md. : 1950). 166: 5629-37. PMID 11313403  1
2001 Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. The Journal of Biological Chemistry. 276: 14642-8. PMID 11279101 DOI: 10.1074/jbc.M100600200  1
2001 Lu C, Shimaoka M, Zang Q, Takagi J, Springer TA. Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains. Proceedings of the National Academy of Sciences of the United States of America. 98: 2393-8. PMID 11226250 DOI: 10.1073/pnas.041618598  1
2001 Lu C, Shimaoka M, Ferzly M, Oxvig C, Takagi J, Springer TA. An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond. Proceedings of the National Academy of Sciences of the United States of America. 98: 2387-92. PMID 11226249 DOI: 10.1073/pnas.041606398  1
2001 Chen S, Springer TA. Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model. Proceedings of the National Academy of Sciences of the United States of America. 98: 950-5. PMID 11158576 DOI: 10.1073/pnas.98.3.950  1
2001 Hioe CE, Chien PC, Lu C, Springer TA, Wang XH, Bandres J, Tuen M. LFA-1 expression on target cells promotes human immunodeficiency virus type 1 infection and transmission. Journal of Virology. 75: 1077-82. PMID 11134324 DOI: 10.1128/JVI.75.2.1077-1082.2001  1
2001 Zang Q, Springer TA. Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2). The Journal of Biological Chemistry. 276: 6922-9. PMID 11096074 DOI: 10.1074/jbc.M005868200  1
2001 Springer TA, Hugentobler U. IGS ultra rapid products for (Near-) real-time applications Physics and Chemistry of the Earth, Part a: Solid Earth and Geodesy. 26: 623-628. DOI: 10.1016/S1464-1895(01)00111-9  0.36
2001 Weber R, Springer TA. The international GLONASS experiment: Products, progress and prospects Journal of Geodesy. 75: 559-568. DOI: 10.1007/s001900100199  0.36
2000 Springer TA, Jing H, Takagi J. A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand. Cell. 102: 275-7. PMID 10975518  1
2000 Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Computational design of an integrin I domain stabilized in the open high affinity conformation. Nature Structural Biology. 7: 674-8. PMID 10932253 DOI: 10.1038/77978  1
2000 Zang Q, Lu C, Huang C, Takagi J, Springer TA. The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3. The Journal of Biological Chemistry. 275: 22202-12. PMID 10781608 DOI: 10.1074/jbc.M002883200  1
2000 Huang C, Zang Q, Takagi J, Springer TA. Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain. The Journal of Biological Chemistry. 275: 21514-24. PMID 10779511 DOI: 10.1074/jbc.M002286200  1
2000 Yalamanchili P, Lu C, Oxvig C, Springer TA. Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1. The Journal of Biological Chemistry. 275: 21877-82. PMID 10764808 DOI: 10.1074/jbc.M908868199  1
1999 Green N, Rosebrook J, Cochran N, Tan K, Wang JH, Springer TA, Briskin MJ. Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains. Cell Adhesion and Communication. 7: 167-81. PMID 10626902  0.6
1999 Bork P, Doerks T, Springer TA, Snel B. Domains in plexins: links to integrins and transcription factors. Trends in Biochemical Sciences. 24: 261-3. PMID 10390613 DOI: 10.1016/S0968-0004(99)01416-4  1
1999 Casasnovas JM, Pieroni C, Springer TA. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Proceedings of the National Academy of Sciences of the United States of America. 96: 3017-22. PMID 10077629  0.36
1999 Oxvig C, Lu C, Springer TA. Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. Proceedings of the National Academy of Sciences of the United States of America. 96: 2215-20. PMID 10051621  0.68
1999 Gerwin N, Gonzalo JA, Lloyd C, Coyle AJ, Reiss Y, Banu N, Wang B, Xu H, Avraham H, Engelhardt B, Springer TA, Gutierrez-Ramos JC. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 10: 9-19. PMID 10023766 DOI: 10.1016/S1074-7613(00)80002-3  1
1999 Chen S, Springer TA. An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear. The Journal of Cell Biology. 144: 185-200. PMID 9885254  0.44
1998 Nagashima M, Shin'oka T, Nollert G, Shum-Tim D, Hickey PR, Roth SJ, Kirchhoff A, Springer TA, Burke PR, Mayer JE. Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia. Circulation. 98: II391-7; discussion . PMID 9852932  1
1998 Alon R, Chen S, Fuhlbrigge R, Puri KD, Springer TA. The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 95: 11631-6. PMID 9751717  0.44
1998 Wang J, Springer TA. Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses. Immunological Reviews. 163: 197-215. PMID 9700512  0.48
1998 Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 9448-53. PMID 9689100 DOI: 10.1073/pnas.95.16.9448  1
1998 Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH. The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. Structure (London, England : 1993). 6: 793-801. PMID 9655832  0.6
1998 Casasnovas JM, Bickford JK, Springer TA. The domain structure of ICAM-1 and the kinetics of binding to rhinovirus. Journal of Virology. 72: 6244-6. PMID 9621098  1
1998 Lu C, Oxvig C, Springer TA. The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains. The Journal of Biological Chemistry. 273: 15138-47. PMID 9614126  0.68
1998 Puri KD, Chen S, Springer TA. Modifying the mechanical property and shear threshold of L-selectin adhesion independently of equilibrium properties. Nature. 392: 930-3. PMID 9582074 DOI: 10.1038/31954  0.44
1998 Petruzzelli L, Maduzia L, Springer TA. Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation. Journal of Immunology (Baltimore, Md. : 1950). 160: 4208-16. PMID 9574521  1
1998 Wang CY, Naka Y, Liao H, Oz MC, Springer TA, Gutierrez-Ramos JC, Pinsky DJ. Cardiac graft intercellular adhesion molecule-1 (ICAM-1) and interleukin-1 expression mediate primary isograft failure and induction of ICAM-1 in organs remote from the site of transplantation. Circulation Research. 82: 762-72. PMID 9562435  1
1998 Oxvig C, Springer TA. Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface. Proceedings of the National Academy of Sciences of the United States of America. 95: 4870-5. PMID 9560195  0.36
1998 Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA. A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proceedings of the National Academy of Sciences of the United States of America. 95: 4134-9. PMID 9539702  0.6
1998 Roth SJ, Diacovo TG, Brenner MB, Rosat JP, Buccola J, Morita CT, Springer TA. Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines. European Journal of Immunology. 28: 104-13. PMID 9485190 DOI: 10.1002/(SICI)1521-4141(199801)28:01<104::AID-IMMU104>3.0.CO;2-F  0.36
1997 Weber C, Lu CF, Casasnovas JM, Springer TA. Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells. Journal of Immunology (Baltimore, Md. : 1950). 159: 3968-75. PMID 9378985  0.36
1997 Kitayama J, Fuhlbrigge RC, Puri KD, Springer TA. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. Journal of Immunology (Baltimore, Md. : 1950). 159: 3929-39. PMID 9378981  0.4
1997 Alon R, Chen S, Puri KD, Finger EB, Springer TA. The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling. The Journal of Cell Biology. 138: 1169-80. PMID 9281593  0.44
1997 Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature. 387: 312-5. PMID 9153399 DOI: 10.1038/387312a0  0.6
1997 Chen S, Alon R, Fuhlbrigge RC, Springer TA. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Proceedings of the National Academy of Sciences of the United States of America. 94: 3172-7. PMID 9096365  0.44
1997 Huang C, Springer TA. Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit. Proceedings of the National Academy of Sciences of the United States of America. 94: 3162-7. PMID 9096363  0.52
1997 Huang C, Lu C, Springer TA. Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit. Proceedings of the National Academy of Sciences of the United States of America. 94: 3156-61. PMID 9096362  0.68
1997 Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 94: 1925-30. PMID 9050881 DOI: 10.1073/pnas.94.5.1925  1
1997 Kitayama J, Carr MW, Roth SJ, Buccola J, Springer TA. Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils. Journal of Immunology (Baltimore, Md. : 1950). 158: 2340-9. PMID 9036983  0.36
1997 Puri KD, Finger EB, Springer TA. The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength. Journal of Immunology (Baltimore, Md. : 1950). 158: 405-13. PMID 8977216  0.4
1996 Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) The Journal of Experimental Medicine. 184: 1101-9. PMID 9064327  0.36
1996 Fuhlbrigge RC, Alon R, Puri KD, Lowe JB, Springer TA. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. The Journal of Cell Biology. 135: 837-48. PMID 8909555  0.4
1996 Parkos CA, Colgan SP, Diamond MS, Nusrat A, Liang TW, Springer TA, Madara JL. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils. Molecular Medicine (Cambridge, Mass.). 2: 489-505. PMID 8827719  1
1996 Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 88: 146-57. PMID 8704169  0.36
1996 Wong DA, Davis EM, LeBeau M, Springer TA. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. Gene. 171: 291-4. PMID 8666289 DOI: 10.1016/0378-1119(95)00869-1  1
1996 Diacovo TG, Puri KD, Warnock RA, Springer TA, von Andrian UH. Platelet-mediated lymphocyte delivery to high endothelial venules. Science (New York, N.Y.). 273: 252-5. PMID 8662511  0.4
1996 Diacovo TG, Roth SJ, Morita CT, Rosat JP, Brenner MB, Springer TA. Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin. The Journal of Experimental Medicine. 183: 1193-203. PMID 8642261  0.36
1996 Dustin ML, Ferguson LM, Chan PY, Springer TA, Golan DE. Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area. The Journal of Cell Biology. 132: 465-74. PMID 8636222  1
1996 Puri KD, Springer TA. A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow. The Journal of Biological Chemistry. 271: 5404-13. PMID 8621395  0.4
1996 Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. The Journal of Clinical Investigation. 97: 1056-63. PMID 8613529 DOI: 10.1172/JCI118498  1
1996 Connolly ES, Winfree CJ, Springer TA, Naka Y, Liao H, Yan SD, Stern DM, Solomon RA, Gutierrez-Ramos JC, Pinsky DJ. Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. The Journal of Clinical Investigation. 97: 209-16. PMID 8550836 DOI: 10.1172/JCI118392  1
1996 Finger EB, Puri KD, Alon R, Lawrence MB, von Andrian UH, Springer TA. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature. 379: 266-9. PMID 8538793 DOI: 10.1038/379266a0  0.4
1995 Roth SJ, Carr MW, Springer TA. C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes. European Journal of Immunology. 25: 3482-8. PMID 8566041 DOI: 10.1002/eji.1830251241  0.36
1995 Gonzalo JA, Martinez C, Springer TA, Gutierrez-Ramos JC. ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. International Immunology. 7: 1691-8. PMID 8562515  1
1995 Roth SJ, Carr MW, Rose SS, Springer TA. Characterization of transendothelial chemotaxis of T lymphocytes. Journal of Immunological Methods. 188: 97-116. PMID 8551044  1
1995 Casasnovas JM, Springer TA. Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance. The Journal of Biological Chemistry. 270: 13216-24. PMID 7768920  0.36
1995 de Fougerolles AR, Diamond MS, Springer TA. Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95. European Journal of Immunology. 25: 1008-12. PMID 7737271 DOI: 10.1002/eji.1830250422  1
1995 Huang C, Springer TA. A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1). The Journal of Biological Chemistry. 270: 19008-16. PMID 7642561  0.52
1995 Petruzzelli L, Maduzia L, Springer TA. Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18. Journal of Immunology (Baltimore, Md. : 1950). 155: 854-66. PMID 7608563  1
1995 Puri KD, Finger EB, Gaudernack G, Springer TA. Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. The Journal of Cell Biology. 131: 261-70. PMID 7559783  0.4
1995 Diamond MS, Alon R, Parkos CA, Quinn MT, Springer TA. Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1). The Journal of Cell Biology. 130: 1473-82. PMID 7559767 DOI: 10.1083/jcb.130.6.1473  1
1995 Sugie K, Nakamura K, Teshigawara K, Diamond MS, Springer TA, Nakamura Y, Leonard WJ, Uchida A, Yodoi J. Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1. International Immunology. 7: 763-9. PMID 7547703 DOI: 10.1093/intimm/7.5.763  1
1995 Kinashi T, Escobedo JA, Williams LT, Takatsu K, Springer TA. Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways. Blood. 86: 2086-90. PMID 7545020  1
1995 Lawrence MB, Berg EL, Butcher EC, Springer TA. Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow. European Journal of Immunology. 25: 1025-31. PMID 7537667 DOI: 10.1002/eji.1830250425  1
1994 Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proceedings of the National Academy of Sciences of the United States of America. 91: 3652-6. PMID 8170963  1
1994 Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA. CD antigens 1993. Blood. 83: 879-80. PMID 8111060  1
1994 Diacovo TG, deFougerolles AR, Bainton DF, Springer TA. A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2. The Journal of Clinical Investigation. 94: 1243-51. PMID 8083366 DOI: 10.1172/JCI117442  0.36
1994 Diamond MS, Springer TA. The dynamic regulation of integrin adhesiveness. Current Biology : Cb. 4: 506-17. PMID 7922371 DOI: 10.1016/S0960-9822(00)00111-1  1
1994 Casasnovas JM, Springer TA. Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released. Journal of Virology. 68: 5882-9. PMID 7914550  0.36
1994 Xu H, Gonzalo JA, St Pierre Y, Williams IR, Kupper TS, Cotran RS, Springer TA, Gutierrez-Ramos JC. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. The Journal of Experimental Medicine. 180: 95-109. PMID 7911822 DOI: 10.1084/jem.180.1.95  1
1994 Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA. CD antigens 1993. Immunology Today. 15: 98-9. PMID 7909665 DOI: 10.1016/0167-5699(94)90149-X  1
1994 Bilsland CA, Springer TA. Cloning and expression of the chicken CD18 cDNA. Journal of Leukocyte Biology. 55: 501-6. PMID 7908319  0.44
1994 Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA. CD antigens 1993. Journal of Immunology (Baltimore, Md. : 1950). 152: 1-2. PMID 7902854  1
1994 Kinashi T, Springer TA. Adhesion molecules in hematopoietic cells. Blood Cells. 20: 25-44. PMID 7527678  1
1994 Borregaard N, Kjeldsen L, Sengeløv H, Diamond MS, Springer TA, Anderson HC, Kishimoto TK, Bainton DF. Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators. Journal of Leukocyte Biology. 56: 80-7. PMID 7517990  1
1994 Bilsland CA, Diamond MS, Springer TA. The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. Journal of Immunology (Baltimore, Md. : 1950). 152: 4582-9. PMID 7512600  1
1994 Vonderheide RH, Tedder TF, Springer TA, Staunton DE. Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. The Journal of Cell Biology. 125: 215-22. PMID 7511143  1
1993 Hondalus MK, Diamond MS, Rosenthal LA, Springer TA, Mosser DM. The intracellular bacterium Rhodococcus equi requires Mac-1 to bind to mammalian cells. Infection and Immunity. 61: 2919-29. PMID 8514396  1
1993 Sengeløv H, Kjeldsen L, Diamond MS, Springer TA, Borregaard N. Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils. The Journal of Clinical Investigation. 92: 1467-76. PMID 8376598 DOI: 10.1172/JCI116724  1
1984 Hemler ME, Sanchez-Madrid F, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, Strominger JL. Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. Journal of Immunology (Baltimore, Md. : 1950). 132: 3011-8. PMID 6327814  0.92
1983 Burakoff SJ, Clayberger C, Hemler M, Krensky AM, Reiss CS, Robbins E, Sanchez-Madrid F, Springer TA, Strominger JL, Ware CF. Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Diagnostic Immunology. 1: 116-9. PMID 6238749  0.96
1983 Ware CF, Sanchez-Madrid F, Krensky AM, Burakoff SJ, Strominger JL, Springer TA. Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity. Journal of Immunology (Baltimore, Md. : 1950). 131: 1182-8. PMID 6193178  0.96
1982 Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proceedings of the National Academy of Sciences of the United States of America. 79: 7489-93. PMID 6984191  0.96
1977 Springer TA, Robb RJ, Terhorst C, Strominger JL. Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens. The Journal of Biological Chemistry. 252: 4694-700. PMID 873911  0.96
1977 Springer TA, Kaufman JF, Siddoway LA, Mann DL, Strominger JL. Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association. The Journal of Biological Chemistry. 252: 6201-7. PMID 302259  0.96
1977 Springer TA, Kaufman JF, Terhorst C, Strominger JL. Purification and structural characterisation of human HLA-linked B-cell antigens. Nature. 268: 213-8. PMID 301990  0.96
1977 Springer TA, Strominger JL. Detergent-soluble products of the HLA region. Transplantation Proceedings. 9: 21-8. PMID 300928  0.96
1977 Springer TA, Kaufman JF, Siddoway LA, Giphart M, Mann DL, Terhorst C, Strominger JL. Chemical and immunological characterization of HL-A linked B-lymphocyte alloantigens. Cold Spring Harbor Symposia On Quantitative Biology. 41: 387-96. PMID 70316  0.96
1977 Springer TA, Mann DL, DeFranco AL, Strominger JL. Detergent solubilization, purification, and separation of specificities of HLA antigens from a cultured human lymphoblastoid line, RPMI 4265. The Journal of Biological Chemistry. 252: 4682-93. PMID 68955  1
1976 Springer TA, Strominger JL. Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region. Proceedings of the National Academy of Sciences of the United States of America. 73: 2481-5. PMID 781677  0.96
1974 Springer TA, Strominger JL, Mann D. Partial purification of detergent-soluble HL-A antigen and its cleavage by papain. Proceedings of the National Academy of Sciences of the United States of America. 71: 1539-43. PMID 4208551  0.96
1974 Strominger JL, Cresswell P, Grey H, Humphreys RE, Mann D, McCuneJ, Parham P, Robb R, Sanderson AR, Springer TA, Terhorst C, Turner MJ. The immunoglobulin-like structure of human histocompatibility antigens. Transplantation Reviews. 21: 126-43. PMID 4139785  1
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