| Year |
Citation |
Score |
| 2017 |
Lin Y, Satani N, Hammoudi N, Pisaneschi F, Leonard P, Maxwell D, Peng Z, Link T, Gilbert LIR, Bosajou A, Sun D, Marszalek J, Sun Y, McMurray JS, Mandal PK, ... ... Bornmann W, et al. Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A39 |
0.392 |
|
| 2016 |
Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BA, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nature Chemical Biology. PMID 27723749 DOI: 10.1038/Nchembio.2195 |
0.337 |
|
| 2016 |
Velez J, Pan R, Lee JT, Enciso L, Suarez M, Duque JE, Jaramillo D, Lopez C, Morales L, Bornmann W, Konopleva M, Krystal G, Andreeff M, Samudio I. Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget. PMID 27283492 DOI: 10.18632/Oncotarget.9843 |
0.304 |
|
| 2016 |
Li LS, Reddy S, Lin ZH, Liu S, Park H, Chun SG, Bornmann WG, Thibodeaux J, Yan J, Chakrabarti G, Xie XJ, Sumer BD, Boothman DA, Yordy JS. NQO1-mediated tumor-selective lethality and radiosensitization for head and neck cancer. Molecular Cancer Therapeutics. PMID 27196777 DOI: 10.1158/1535-7163.Mct-15-0765 |
0.313 |
|
| 2016 |
Lin Y, Satani N, Hammoudi N, Pisaneschi F, Leonard P, Maxwell D, Peng Z, Link T, Lee G, Sun D, Marszalek J, Sun Y, McMurray J, Mandal P, Di Francesco M, ... Bornmann W, et al. POMHEX, a cell-permeable enolase inhibitor for collateral lethality targeting of ENO1-deleted glioblastoma European Journal of Cancer. 69: S124. DOI: 10.1016/S0959-8049(16)32968-9 |
0.306 |
|
| 2014 |
Caruso JA, Campana R, Wei C, Su CH, Hanks AM, Bornmann WG, Keyomarsi K. Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells. Cell Cycle (Georgetown, Tex.). 13: 2587-99. PMID 25486199 DOI: 10.4161/15384101.2015.942210 |
0.306 |
|
| 2014 |
Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff M. Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Molecular Cancer Therapeutics. 13: 1848-59. PMID 24739393 DOI: 10.1158/1535-7163.Mct-13-0576 |
0.348 |
|
| 2014 |
Cao L, Li LS, Spruell C, Xiao L, Chakrabarti G, Bey EA, Reinicke KE, Srougi MC, Moore Z, Dong Y, Vo P, Kabbani W, Yang CR, Wang X, Fattah F, ... ... Bornmann WG, et al. Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers. Antioxidants & Redox Signaling. 21: 237-50. PMID 24512128 DOI: 10.1089/Ars.2013.5462 |
0.305 |
|
| 2014 |
Peng Z, Maxwell DS, Sun D, Bhanu Prasad BA, Schuber PT, Pal A, Ying Y, Han D, Gao L, Wang S, Levitzki A, Kapuria V, Talpaz M, Young M, Showalter HD, ... ... Bornmann WG, et al. Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I). Bioorganic & Medicinal Chemistry. 22: 1450-8. PMID 24457091 DOI: 10.1016/J.Bmc.2013.12.048 |
0.373 |
|
| 2014 |
Pal A, Sung B, Bhanu Prasad BA, Schuber PT, Prasad S, Aggarwal BB, Bornmann WG. Curcumin glucuronides: Assessing the proliferative activity against human cell lines Bioorganic and Medicinal Chemistry. 22: 435-439. PMID 24280069 DOI: 10.1016/J.Bmc.2013.11.006 |
0.346 |
|
| 2014 |
Peng Z, Maxwell DS, Sun D, Bhanu Prasad BA, Pal A, Wang S, Balatoni J, Ghosh P, Lim ST, Volgin A, Shavrin A, Alauddin MM, Gelovani JG, Bornmann WG. Imatinib analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at a kinase level. Bioorganic & Medicinal Chemistry. 22: 623-32. PMID 24280068 DOI: 10.1016/J.Bmc.2013.10.040 |
0.341 |
|
| 2014 |
Wu CF, Liu S, Lee YC, Wang R, Sun S, Yin F, Bornmann WG, Yu-Lee LY, Gallick GE, Zhang W, Lin SH, Kuang J. RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 33: 2385-94. PMID 23708659 DOI: 10.1038/Onc.2013.182 |
0.307 |
|
| 2014 |
Huang X, Moore Z, Luo X, Chakrabarti G, Ilcheva M, Brekken R, Burma S, Gao J, Deberardinis R, Bornmann W, Hergenrother P, Boothman DA. Abstract 787: DNA repair and metabolism inhibitors are tumor-selective when combined with NQO1 bioactivatable drugs for therapy against pancreatic and nonsmall cell lung cancers Cancer Research. 74: 787-787. DOI: 10.1158/1538-7445.Am2014-787 |
0.321 |
|
| 2014 |
Zuo M, Maxwell D, Prasad BAB, Peng Z, Bornmann W, Javle MM. Abstract 5361: Development of targeted inhibitors against RecQ1 helicase Cancer Research. 74: 5361-5361. DOI: 10.1158/1538-7445.Am2014-5361 |
0.398 |
|
| 2014 |
Bornmann WG, Peng Z, Maxwell D, Sun D, Bhanu BA, Talpaz M, Donato N, Levitzki A. Abstract 2698: Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I) Cancer Research. 74: 2698-2698. DOI: 10.1158/1538-7445.Am2014-2698 |
0.373 |
|
| 2014 |
Chiao PJ, Zhuang Z, Xia Q, Schuber PT, Sun D, Peng Z, Maxwell DS, Bornmann WG. Abstract 1727: Development of novel TAK1 inhibitors for pancreatic cancer Cancer Research. 74: 1727-1727. DOI: 10.1158/1538-7445.Am2014-1727 |
0.373 |
|
| 2013 |
Pal A, Peng Z, Schuber PT, Bhanu Prasad BA, Bornmann WG. Asymmetric Synthesis of the C1-C6 Portion of the Psymberin Using an Evans Chiral Auxiliary. Tetrahedron Letters. 54: 5555-5567. PMID 25110364 DOI: 10.1016/J.Tetlet.2013.05.153 |
0.304 |
|
| 2013 |
Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, Bornmann WG, Eshleman AJ, Janowsky A, Simon ER, Reith ME, Alper K. Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation. Plos One. 8: e77262. PMID 24204784 DOI: 10.1371/Journal.Pone.0077262 |
0.539 |
|
| 2013 |
Vanderslice P, Biediger RJ, Woodside DG, Brown WS, Khounlo S, Warier ND, Gundlach CW, Caivano AR, Bornmann WG, Maxwell DS, McIntyre BW, Willerson JT, Dixon RA. Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion. The Journal of Biological Chemistry. 288: 19414-28. PMID 23703610 DOI: 10.1074/Jbc.M113.479634 |
0.322 |
|
| 2013 |
Arumugam T, Ramachandran V, Sun D, Peng Z, Pal A, Maxwell DS, Bornmann WG, Logsdon CD. Designing and developing S100P inhibitor 5-methyl cromolyn for pancreatic cancer therapy. Molecular Cancer Therapeutics. 12: 654-62. PMID 23303403 DOI: 10.1158/1535-7163.Mct-12-0771 |
0.309 |
|
| 2013 |
Angelo LS, Maxwell DS, Wu JY, Sun D, Hawke DH, McCutcheon IE, Slopis JM, Peng Z, Bornmann WG, Kurzrock R. Binding partners for curcumin in human schwannoma cells: biologic implications. Bioorganic & Medicinal Chemistry. 21: 932-9. PMID 23294827 DOI: 10.1016/J.Bmc.2012.12.008 |
0.32 |
|
| 2013 |
Maxwell DS, Sun D, Peng Z, Qi W, McConkey D, Abbruzzese JL, Bornmann WG. Abstract B101: Design and optimization of a new series of HSP70 inhibitors for use in the treatment of pancreatic cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B101 |
0.367 |
|
| 2012 |
Konopleva M, Milella M, Ruvolo P, Watts JC, Ricciardi MR, Korchin B, McQueen T, Bornmann W, Tsao T, Bergamo P, Mak DH, Chen W, McCubrey J, Tafuri A, Andreeff M. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex Leukemia. 26: 778-787. PMID 22064351 DOI: 10.1038/Leu.2011.287 |
0.36 |
|
| 2012 |
Zhou Y, Tozzi F, Xia L, Fan F, Lu J, Maxwell D, Gao G, Bornmann W, Weihua Z, Ellis LM. Abstract B64: Development of a novel strategy to overcome drug resistance by targeting ATP citrate lyase and de novo lipogenesis in colorectal cancer cells Clinical Cancer Research. 18: B64-B64. DOI: 10.1158/1078-0432.Mechres-B64 |
0.334 |
|
| 2011 |
Peng Z, Pal A, Han D, Wang S, Maxwell D, Levitzki A, Talpaz M, Donato NJ, Bornmann W. Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma. Bioorganic & Medicinal Chemistry. 19: 7194-204. PMID 22036213 DOI: 10.1016/J.Bmc.2011.09.057 |
0.379 |
|
| 2011 |
Kapuria V, Levitzki A, Bornmann WG, Maxwell D, Priebe W, Sorenson RJ, Showalter HD, Talpaz M, Donato NJ. A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination Cellular Signalling. 23: 2076-2085. PMID 21855629 DOI: 10.1016/J.Cellsig.2011.08.002 |
0.33 |
|
| 2011 |
Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, Rosner GL, Yu Y, Ahmed AA, Bast RC. Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. Cancer. 117: 4424-38. PMID 21491416 DOI: 10.1002/Cncr.26073 |
0.311 |
|
| 2011 |
Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Research. 71: 3658-68. PMID 21444672 DOI: 10.1158/0008-5472.Can-10-3647 |
0.301 |
|
| 2011 |
Sun H, Kapuria V, Peterson LF, Fang D, Bornmann WG, Bartholomeusz G, Talpaz M, Donato NJ. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis Blood. 117: 3151-3162. PMID 21248063 DOI: 10.1182/Blood-2010-03-276477 |
0.35 |
|
| 2011 |
Nawrocki ST, Espitia CM, Kelly KR, Bornmann WG, Carew JS. Small Molecule Inhibition of SIRT Activity: A Novel Therapeutic Approach for Acute Myeloid Leukemia Blood. 118: 84-84. DOI: 10.1182/Blood.V118.21.84.84 |
0.35 |
|
| 2011 |
Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. Abstract LB-400: STAT3 mediates resistance to MEK inhibitor through microRNA miR-17 Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-400 |
0.308 |
|
| 2011 |
Lan PV, Tamayo AT, Li C, Sun D, Pal A, Peng Z, Maxwell D, Ford RJ, Bornmann WG. Abstract A129: Development of turmerax therapeutic compounds in aggressive, refractory B cell non-Hodgkin's lymphoma. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A129 |
0.329 |
|
| 2011 |
Kupferman ME, Lee J, Sun D, Peng Z, Maxwell DS, Bornmann WG. Abstract A122: Therapeutic modulation of Trkb in head and neck squamous cell carcinoma. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A122 |
0.39 |
|
| 2010 |
Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, Peng Z, Herbst RS, Papadimitrakopoulou V, Minna JD, Peyton M, Roth JA. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. Plos One. 5: e14124. PMID 21124782 DOI: 10.1371/Journal.Pone.0014124 |
0.335 |
|
| 2010 |
Kapuria V, Peterson LF, Fang D, Bornmann WG, Talpaz M, Donato NJ. Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis Cancer Research. 70: 9265-9276. PMID 21045142 DOI: 10.1158/0008-5472.Can-10-1530 |
0.373 |
|
| 2010 |
Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN, Hung MC. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation Oncogene. 29: 5619-5629. PMID 20676141 DOI: 10.1038/Onc.2010.295 |
0.33 |
|
| 2010 |
Pham LV, Tamayo AT, Li C, Bornmann W, Priebe W, Ford RJ. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Molecular Cancer Therapeutics. 9: 2026-36. PMID 20606045 DOI: 10.1158/1535-7163.Mct-10-0238 |
0.361 |
|
| 2010 |
Swimm AI, Bornmann W, Jiang M, Imperiale MJ, Lukacher AE, Kalman D. Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. Journal of Virology. 84: 4243-51. PMID 20181697 DOI: 10.1128/Jvi.00129-10 |
0.307 |
|
| 2010 |
Wu J, Meng F, Ying Y, Peng Z, Daniels L, Bornmann WG, Quintás-Cardama A, Roulston D, Talpaz M, Peterson LF, Donato NJ. ON012380, a putative BCR-ABL kinase inhibitor with a unique mechanism of action in imatinib-resistant cells Leukemia. 24: 869-872. PMID 20111070 DOI: 10.1038/Leu.2009.300 |
0.314 |
|
| 2010 |
Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction Journal of Clinical Investigation. 120: 142-156. PMID 20038799 DOI: 10.1172/Jci38942 |
0.319 |
|
| 2010 |
Vivas-Mejia P, Benito JM, Fernandez A, Han HD, Mangala L, Rodriguez-Aguayo C, Chavez-Reyes A, Lin YG, Carey MS, Nick AM, Stone RL, Kim HS, Claret FX, Bornmann W, Hennessy BT, et al. c-Jun-NH2-kinase-1 inhibition leads to antitumor activity in ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 184-94. PMID 20028751 DOI: 10.1158/1078-0432.Ccr-09-1180 |
0.347 |
|
| 2010 |
Xie X, Bartholomeusz C, Maxwell D, Peng Z, Kazansky A, Bornmann W, Ueno N. Abstract P6-15-20: Development of PEA-15-Based Therapy in Breast Cancer in a Preclinical Study Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-P6-15-20 |
0.31 |
|
| 2009 |
Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D. Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Molecular Cancer Therapeutics. 8: 1157-68. PMID 19417153 DOI: 10.1158/1535-7163.Mct-08-1008 |
0.361 |
|
| 2009 |
Faderl S, Pal A, Bornmann W, Albitar M, Maxwell D, Van Q, Peng Z, Harris D, Liu Z, Hazan-Halevy I, Kantarjian HM, Estrov Z. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Research. 69: 3910-7. PMID 19383925 DOI: 10.1158/0008-5472.Can-08-0034 |
0.373 |
|
| 2009 |
Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J, Williams R, Lemos R, Oh J, Volgin A, Soghomonyan S, Nishii R, Alauddin M, Mukhopadhay U, Peng Z, Bornmann W, et al. The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Molecular Cancer Therapeutics. 8: 947-58. PMID 19372568 DOI: 10.1158/1535-7163.Mct-08-0981 |
0.312 |
|
| 2009 |
Andreeff M, Fiegl M, Konopleva M, Korchin B, Kaluarachchi K, Bornmann WG, Guthrie PH, Harmancey R, Taegtmeyer H, Samudio IJ. Pharmacological Inhibition of Fatty Acid Oxidation as a Novel Therapeutic Concept for Acute Myeloid Leukemia. Blood. 114: 3779-3779. DOI: 10.1182/Blood.V114.22.3779.3779 |
0.329 |
|
| 2009 |
Donato NJ, Sun H, Kapuria V, Peterson LF, Bartholomeusz G, Bornmann WG, Talpaz M. WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells. Blood. 114: 3303-3303. DOI: 10.1182/Blood.V114.22.3303.3303 |
0.365 |
|
| 2009 |
Kapuria V, Peterson LF, Bornmann W, Talpaz M, Donato NJ. Inhibition of Cytokine Signaling through Activation of Jak2 Ubiquitination by WP1130. Blood. 114: 2907-2907. DOI: 10.1182/Blood.V114.22.2907.2907 |
0.36 |
|
| 2009 |
Faderl S, Bueso-Ramos C, Liu Z, Pal A, Bornmann W, Harris D, Hazan-Halevy I, Kantarjian HM, Estrov Z. APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model. Blood. 114: 1045-1045. DOI: 10.1182/Blood.V114.22.1045.1045 |
0.308 |
|
| 2008 |
Ghosh P, Pal A, Shavrin A, Bornmann W, Gelovani JG, Alauddin MM. Synthesis of N3-substituted thymidine analogues for measurement of cellular kinase activity Medicinal Chemistry. 4: 503-512. PMID 18782048 DOI: 10.2174/157340608785700252 |
0.352 |
|
| 2008 |
Wu J, Meng F, Kong LY, Peng Z, Ying Y, Bornmann WG, Darnay BG, Lamothe B, Sun H, Talpaz M, Donato NJ. Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase Journal of the National Cancer Institute. 100: 926-939. PMID 18577747 DOI: 10.1093/Jnci/Djn188 |
0.308 |
|
| 2008 |
Wagner MW, Long SL, Morales JC, Galindo CL, Garner HR, Bornmann WG, Boothman DA. Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses Journal of Biological Chemistry. 283: 21382-21393. PMID 18480061 DOI: 10.1074/Jbc.M709953200 |
0.323 |
|
| 2008 |
Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z, Bornmann W, Kantarjian H, Viallet J, Samudio I, Andreeff M. Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (Obatoclax) Cancer Research. 68: 3413-3420. PMID 18451169 DOI: 10.1158/0008-5472.Can-07-1919 |
0.323 |
|
| 2008 |
Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/J.Str.2007.12.016 |
0.308 |
|
| 2008 |
Yamaguchi H, Ding Y, Lee JF, Zhang M, Pal A, Bornmann W, Yan DH, Hung MC. Interferon-inducible protein IFIXα inhibits cell invasion by upregulating the metastasis suppressor maspin Molecular Carcinogenesis. 47: 739-743. PMID 18247378 DOI: 10.1002/Mc.20423 |
0.329 |
|
| 2008 |
Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, Talpaz M, Donato NJ. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells Blood. 111: 3821-3829. PMID 18235045 DOI: 10.1182/Blood-2007-08-109330 |
0.332 |
|
| 2008 |
Zhang W, Konopleva M, Ruvolo VR, McQueen T, Evans RL, Bornmann WG, McCubrey J, Cortes J, Andreeff M. Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway Leukemia. 22: 808-818. PMID 18200035 DOI: 10.1038/Sj.Leu.2405098 |
0.34 |
|
| 2008 |
Peterson LF, Sun H, Bornmann W, Peng Z, Maxwell D, Donato N, Talpaz M. Degrasyn (a novel tyrophostin) Impacts BCR-ABL Protein Level and Is Cytotoxic to Chronic Myeloid Leukemia Early Progenitors Blood. 112: 3212-3212. DOI: 10.1182/Blood.V112.11.3212.3212 |
0.372 |
|
| 2008 |
Konopleva M, Tsao T, Ling X, Kojima K, Watt J, Mak DH, Verhaegen M, Bornmann W, Soengas M, Andreeff M. Activation of p53 Signaling Is Synergistically Enhanced by Bcl-2 Inhibition through Induction of Noxa and Bak/Bax Heterodimers Resulting in Apoptosis of AML Stem Cells Blood. 112: 2940-2940. DOI: 10.1182/Blood.V112.11.2940.2940 |
0.306 |
|
| 2007 |
Fernández A, Sanguino A, Peng Z, Ozturk E, Chen J, Crespo A, Wulf S, Shavrin A, Qin C, Ma J, Trent J, Lin Y, Han HD, Mangala LS, Bankson JA, ... Bornmann W, et al. An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. The Journal of Clinical Investigation. 117: 4044-54. PMID 18060038 DOI: 10.1172/Jci32373 |
0.347 |
|
| 2007 |
Halder J, Lin YG, Merritt WM, Spannuth WA, Nick AM, Honda T, Kamat AA, Han LY, Tae JK, Lu C, Tari AM, Bornmann W, Fernandez A, Lopez-Berestein G, Sood AK. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma Cancer Research. 67: 10976-10983. PMID 18006843 DOI: 10.1158/0008-5472.Can-07-2667 |
0.362 |
|
| 2007 |
Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone Proceedings of the National Academy of Sciences of the United States of America. 104: 11832-11837. PMID 17609380 DOI: 10.1073/Pnas.0702176104 |
0.316 |
|
| 2007 |
Fernández A, Sanguino A, Peng Z, Crespo A, Ozturk E, Zhang X, Wang S, Bornmann W, Lopez-Berestein G. Rational drug redesign to overcome drug resistance in cancer therapy: Imatinib moving target Cancer Research. 67: 4028-4033. PMID 17483313 DOI: 10.1158/0008-5472.Can-07-0345 |
0.306 |
|
| 2007 |
Bartholomeusz G, Talpaz M, Bornmann W, Kong LY, Donato NJ. Degrasyn activates proteasomal-dependent degradation of c-Myc Cancer Research. 67: 3912-3918. PMID 17440106 DOI: 10.1158/0008-5472.Can-06-4464 |
0.302 |
|
| 2007 |
Faderl S, Bornmann W, Maxwell D, Peng Z, Van Q, Liu Z, Verstovsek S, Ferrajoli A, Kantarjian HM, Estrov Z. Molecular targeting in acute myeloid leukemia (AML) therapy: APcK110 is a new inhibitor of c-Kit activity in AML blasts Journal of Clinical Oncology. 25: 7019-7019. DOI: 10.1200/Jco.2007.25.18_Suppl.7019 |
0.373 |
|
| 2007 |
Kapuria V, Bartholomeusz G, Kong L, Bornmann W, Peng Z, Pal A, Maxwell D, Talpaz M, Donato N. A Novel Small-Molecule Approach To Inhibit Jak2 Tyrosine Kinase Signaling. Blood. 110: 1556-1556. DOI: 10.1182/Blood.V110.11.1556.1556 |
0.352 |
|
| 2007 |
Donato N, Kapuria V, Sun H, Maxwell D, Bartholomeusz G, Bornmann W, Peng Z, Pal A, Talpaz M. Degrasyn-Induced Trafficking of BCR-ABL as a Novel Mechanism of Kinase Inactivation. Blood. 110: 1003-1003. DOI: 10.1182/Blood.V110.11.1003.1003 |
0.357 |
|
| 2006 |
Kojima K, Konopleva M, Samudio IJ, Schober WD, Bornmann WG, Andreeff M. Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML Cell Cycle. 5: 2778-2786. PMID 17172851 DOI: 10.4161/Cc.5.23.3520 |
0.304 |
|
| 2006 |
Pedranzini L, Dechow T, Berishaj M, Comenzo R, Zhou P, Azare J, Bornmann W, Bromberg J. Pyridone 6, a Pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells Cancer Research. 66: 9714-9721. PMID 17018630 DOI: 10.1158/0008-5472.Can-05-4280 |
0.342 |
|
| 2006 |
Pal A, Glekas A, Doubrovin M, Balatoni J, Beresten T, Maxwell D, Soghomonyan S, Shavrin A, Ageyeva L, Finn R, Larson SM, Bornmann W, Gelovani JG. Molecular Imaging of EGFR kinase activity in tumors with 124 I-Labeled small molecular tracer and positron emission tomography Molecular Imaging and Biology. 8: 262-277. PMID 16897320 DOI: 10.1007/S11307-006-0049-0 |
0.327 |
|
| 2006 |
Azam M, Nardi V, Shakespeare WC, Metcalf CA, Bohacek RS, Wang Y, Sundaramoorthi R, Sliz P, Veach DR, Bornmann WG, Clarkson B, Dalgarno DC, Sawyer TK, Daley GQ. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 103: 9244-9. PMID 16754879 DOI: 10.1073/Pnas.0600001103 |
0.338 |
|
| 2006 |
Sankaranarayanapillai M, Tong WP, Maxwell DS, Pal A, Pang J, Bornmann WG, Gelovani JG, Ronen SM. Detection of histone deacetylase inhibition by noninvasive magnetic resonance spectroscopy. Molecular Cancer Therapeutics. 5: 1325-34. PMID 16731766 DOI: 10.1158/1535-7163.Mct-05-0494 |
0.307 |
|
| 2006 |
Wendel HG, De Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition Proceedings of the National Academy of Sciences of the United States of America. 103: 7444-7449. PMID 16651519 DOI: 10.1073/Pnas.0602402103 |
0.345 |
|
| 2006 |
Nawrocki ST, Carew JS, Pino MS, Highshaw RA, Andtbacka RHI, Dunner K, Pal A, Bornmann WG, Chiao PJ, Huang P, Xiong H, Abbruzzese JL, McConkey DJ. Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells Cancer Research. 66: 3773-3781. PMID 16585204 DOI: 10.1158/0008-5472.Can-05-2961 |
0.344 |
|
| 2006 |
O'Brian CA, Chu F, Bornmann WG, Maxwell DS. Protein kinase Calpha and epsilon small-molecule targeted therapeutics: a new roadmap to two Holy Grails in drug discovery? Expert Review of Anticancer Therapy. 6: 175-86. PMID 16445370 DOI: 10.1586/14737140.6.2.175 |
0.317 |
|
| 2006 |
Donato NJ, Wu J, Bornmann W, Talpaz M. Activity of ABL Kinase Inhibitors in Two Distinct Models of Imatinib Resistance. Blood. 108: 4819-4819. DOI: 10.1182/Blood.V108.11.4819.4819 |
0.343 |
|
| 2006 |
Kapuria V, Bartholomeusz G, Bornmann W, Kong LY, Talpaz M, Donato NJ. Inhibition of JAK2/STAT Signaling by Degrasyn through a Novel Mechanism. Blood. 108: 3423-3423. DOI: 10.1182/Blood.V108.11.3423.3423 |
0.35 |
|
| 2006 |
Maxwell DS, Pal A, Peng Z, Shavrin A, Faderl S, Harris D, Van Q, Liu Z, Verstovsek S, Manshouri T, Ferrajoli A, Kantarjian HM, Estrov Z, Bornmann WG. Structure-Based Drug Design of c-Kit Inhibitors for Use in the Treatment of Acute Myeloid Leukemia. Blood. 108: 1906-1906. DOI: 10.1182/Blood.V108.11.1906.1906 |
0.374 |
|
| 2006 |
Faderl S, Bornmann W, Maxwell D, Pal A, Peng Z, Shavrin A, Harris D, Van Q, Zhiming L, Verstovsek S, Manshouri T, Ferrajoli A, Kantarjian HM, Estrov Z. APCK110, a Novel and Potent Inhibitor of c-Kit, Blocks Phosphorylation of AKT and STAT3, Induces Apoptosis, and Inhibits Proliferation of Acute Myeloid Leukemia (AML) Cells. Blood. 108: 153-153. DOI: 10.1182/Blood.V108.11.153.153 |
0.37 |
|
| 2005 |
Reeves PM, Bommarius B, Lebeis S, McNulty S, Christensen J, Swimm A, Chahroudi A, Chavan R, Feinberg MB, Veach D, Bornmann W, Sherman M, Kalman D. Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nature Medicine. 11: 731-9. PMID 15980865 DOI: 10.1038/Nm1265 |
0.306 |
|
| 2004 |
Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. The Journal of Clinical Investigation. 114: 1107-16. PMID 15489958 DOI: 10.1172/Jci22269 |
0.329 |
|
| 2004 |
Tipping AJ, Baluch S, Barnes DJ, Veach DR, Clarkson BM, Bornmann WG, Mahon FX, Goldman JM, Melo JV. Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate Leukemia. 18: 1352-1356. PMID 15201856 DOI: 10.1038/Sj.Leu.2403416 |
0.349 |
|
| 2003 |
Kuehne ME, Bornmann WG, Markó I, Qin Y, LeBoulluec KL, Frasier DA, Xu F, Mulamba T, Ensinger CL, Borman LS, Huot AE, Exon C, Bizzarro FT, Cheung JB, Bane SL. Syntheses and biological evaluation of vinblastine congeners Organic and Biomolecular Chemistry. 1: 2120-2136. PMID 12945903 DOI: 10.1039/B209990J |
0.645 |
|
| 2001 |
Stachel SJ, Chul Bom Lee, Spassova M, Chappell MD, Bornmann WG, Danishefsky SJ, Chou TC, Guan Y. On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: Total synthesis and comparative in vivo evaluations of the 15-Aza epothilones Journal of Organic Chemistry. 66: 4369-4378. PMID 11397179 DOI: 10.1021/Jo010275C |
0.305 |
|
| 1998 |
Chou TC, Depew KM, Zheng YH, Safer ML, Chan D, Helfrich B, Zatorska D, Zatorski A, Bornmann W, Danishefsky SJ. Reversal of anticancer multidrug resistance by the ardeemins. Proceedings of the National Academy of Sciences of the United States of America. 95: 8369-74. PMID 9653193 DOI: 10.1073/Pnas.95.14.8369 |
0.313 |
|
| 1997 |
Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proceedings of the National Academy of Sciences of the United States of America. 94: 6099-103. PMID 9177176 DOI: 10.1073/Pnas.94.12.6099 |
0.338 |
|
| 1993 |
Borman LS, Bornmann WG, Kuehne ME. Modulation of drug cytotoxicity in wild-type and multidrug-resistant tumor cells by stereoisomeric series of C-20′-vinblastine congeners that lack antimicrotubule activity Cancer Chemotherapy and Pharmacology. 31: 343-349. PMID 8431967 DOI: 10.1007/Bf00686146 |
0.589 |
|
| 1992 |
Deecher DC, Teitler M, Soderlund DM, Bornmann WG, Kuehne ME, Glick SD. Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies Brain Research. 571: 242-247. PMID 1377086 DOI: 10.1016/0006-8993(92)90661-R |
0.532 |
|
| 1992 |
Bornmann WG, Kuehne ME. A common intermediate providing syntheses of ψ-tabersonine, coronaridine, iboxyphylline, ibophyllidine, vinamidine, and vinblastine Journal of Organic Chemistry. 57: 1752-1760. DOI: 10.1021/Jo00032A029 |
0.577 |
|
| 1991 |
Kuehne ME, Matson PA, Bornmann WG. Enantioselective syntheses of vinblastine, leurosidine, vincovaline, and 20′-epi-vincovaline Journal of Organic Chemistry. 56: 513-528. DOI: 10.1021/Jo00002A008 |
0.587 |
|
| 1989 |
Kuehne ME, Bornmann WG. Syntheses of 20′-deoxyvinblastine, 20′-deoxyleurosidine, 20′-deoxyvincovaline, 20′-epi-20′-deoxyvincovaline, and 20′-deoxyvincristine and its 20′-epimer through racemic and enantioselectively generated intermediates. New syntheses of D/E-cis- and -trans-ψ-vincadifformines and D/E-cis- and -trans-20-epi-ψ-vincadifformines Journal of Organic Chemistry. 54: 3407-3420. DOI: 10.1021/Jo00275A029 |
0.552 |
|
| 1989 |
Spitzer T, Kuehne ME, Bornmann W, Anklin C. Heteronuclear correlation via spin-locked zero- and multiple-quantum coherences Journal of Magnetic Resonance (1969). 84: 654-657. DOI: 10.1016/0022-2364(89)90134-0 |
0.495 |
|
| 1989 |
KUEHNE ME, BORNMANN WG, PARSONS WH, SPITZER TD, BLOUNT JF, ZUBIETA J. ChemInform Abstract: Total Syntheses of (.+-.)-Cephalotaxine (Ia) and (.+-.)-8-Oxocephalotaxine (Ib). Cheminform. 20. DOI: 10.1002/chin.198901265 |
0.531 |
|
| 1988 |
Kuehne ME, Bornmann WG, Parsons WH, Spitzer TD, Blount JF, Zubieta J. Total syntheses of (.+-.)-cephalotaxine and (.+-.)-8-oxocephalotaxine The Journal of Organic Chemistry. 53: 3439-3450. DOI: 10.1021/Jo00250A008 |
0.571 |
|
| 1988 |
Kuehne ME, Bornmann WG, Parsons WH, Spitzer TD, Blount JF, Zubieta J. Total syntheses of (±)-cephalotaxine and (±)-8-oxocephalotaxine Journal of Organic Chemistry. 53: 3439-3450. |
0.463 |
|
| 1987 |
Kuehne ME, Podhorez DE, Mulamba T, Bornmann WG. Biomimetic alkaloid syntheses. 15. Enantioselective syntheses with epichlorohydrin: total syntheses of (+)-, (-)- and (.+-.)-vindoline and a synthesis of (-)-vindorosine Journal of Organic Chemistry. 52: 347-353. DOI: 10.1021/Jo00379A006 |
0.595 |
|
| 1987 |
Kuehne ME, Zebovitz TC, Bornmann WG, Marko I. Three routes to the critical C16'-C14' parf relative stereochemistry of vinblastine. Syntheses of 20'-desethyl-20'-deoxyvinblastine, and 20'-desethyl-20'-deoxyvincovaline Journal of Organic Chemistry. 52: 4340-4349. DOI: 10.1021/Jo00228A035 |
0.541 |
|
| 1987 |
KUEHNE ME, PODHOREZ DE, MULAMBA T, BORNMANN WG. ChemInform Abstract: Biomimetic Alkaloid Syntheses. Part 15. Enantioselective Syntheses with Epichlorohydrin: Total Syntheses of (+)-, (-)-, and (.+-.)-Vindoline (I) and a Synthesis of (-)-Vindorosine (II). Cheminform. 18. DOI: 10.1002/chin.198735339 |
0.545 |
|
| 1987 |
Kuehne ME, Zebovitz TC, Bornmann WG, Marko I. Three routes to the critical C16′-C14′ parf relative stereochemistry of vinblastine. Syntheses of 20′-desethyl-20′-deoxyvinblastine and 20′-desethyl-20′-deoxyvincovaline Journal of Organic Chemistry. 52: 4340-4349. |
0.53 |
|
| 1987 |
Kuehne ME, Podhorez DE, Mulamba T, Bornmann WG. Biomimetic alkaloid syntheses. 15. Enantioselective syntheses with epichlorohydrin: Total syntheses of (+)-, (-)-, and (±)-vindoline and a synthesis of (-)-vindorosine Journal of Organic Chemistry. 52: 347-353. |
0.533 |
|
| 1986 |
Kuehne ME, Bornmann WG, Earley WG, Marko I. Studies in biomimetic alkaloid syntheses. 14. Controlled, selective syntheses of catharanthine and tabersonine, and related desethyl compounds, through generation of 15-oxosecodine intermediates Journal of Organic Chemistry. 51: 2913-2927. DOI: 10.1021/Jo00365A012 |
0.586 |
|
| 1986 |
Kuehne ME, Bornmann WG, Earley WG, Marko I. Studies in biomimetic alkaloid syntheses. 14. Controlled, selective syntheses of catharanthine and tabersonine, and related desethyl compounds, through generation of 15-oxosecodine intermediates Journal of Organic Chemistry. 51: 2913-2927. |
0.547 |
|
| 1985 |
Kuehne ME, Bohnert JC, Bornmann WG, Kirkemo CL, Kuehne SE, Seaton PJ, Zebovitz TC. Biomimetic syntheses of indole alkaloids. 11. Syntheses of .beta.-carboline and indoloazepine intermediates Journal of Organic Chemistry. 50: 919-924. DOI: 10.1021/Jo00207A001 |
0.57 |
|
| 1985 |
Kuehne ME, Bohnert JC, Bornmann WG, Kirkemo CL, Kuehne SE, Seaton PJ, Zebovitz TC. BIOMIMETIC SYNTHESES OF INDOLE ALKALOIDS. 11. SYNTHESES OF β-CARBOLINE AND INDOLOAZEPINE INTERMEDIATES Cheminform. 16. DOI: 10.1002/Chin.198535326 |
0.567 |
|
| 1985 |
Kuehne ME, Bohnert JC, Bornmann WG, Kirkemo CL, Kuehne SE, Seaton PJ, Zebovitz TC. Biomimetic syntheses of indole alkaloids. 11. Syntheses of β-carboline and indoloazepine intermediates Journal of Organic Chemistry. 50: 919-924. |
0.526 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1993 |
Shen W, Coburn CA, Bornmann WG, Danishefsky SJ. Concise total syntheses of dl-camptothecin and related anticancer drugs Journal of Organic Chemistry. 58: 611-617. DOI: 10.1021/Jo00055A012 |
0.3 |
|
| 2009 |
Robertson F, Woodward W, Bornmann W, Player A, Ye Z, Cristofanilli M. The pan-HDAC Inhibitor Suberoylanilide Hydroxamic Acid Targets Self Renewal of Breast Cancer Stem Cells. Cancer Research. 69: 3141-3141. DOI: 10.1158/0008-5472.Sabcs-09-3141 |
0.298 |
|
| 2013 |
Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, et al. Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers Molecular Cancer Therapeutics. 12: 2110-2120. PMID 23883585 DOI: 10.1158/1535-7163.Mct-12-0962 |
0.298 |
|
| 2007 |
Berishaj M, Gao SP, Ahmed S, Leslie K, Al-Ahmadie H, Gerald WL, Bornmann W, Bromberg JF. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer Breast Cancer Research. 9. PMID 17531096 DOI: 10.1186/Bcr1680 |
0.297 |
|
| 2011 |
Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA. Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy Clinical Cancer Research. 17: 275-285. PMID 21224367 DOI: 10.1158/1078-0432.Ccr-10-1983 |
0.296 |
|
| 2013 |
Sun D, Bhanu Prasad BA, Schuber PT, Peng Z, Maxwell DS, Martin DV, Guo L, Han D, Kurihara H, Yang DJ, Gelovani JG, Powis G, Bornmann WG. Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [(131)I] analogue as useful PET tracers for PI3-kinase. Bioorganic & Medicinal Chemistry. 21: 5182-7. PMID 23859776 DOI: 10.1016/J.Bmc.2013.06.036 |
0.296 |
|
| 1992 |
Queneau Y, Krol WJ, Bornmann WG, Danishefsky SJ. A ready synthesis of intermediates containing the A-ring substructure of taxol : a Diels-Alder route to the B-seco taxane series Journal of Organic Chemistry. 57: 4043-4047. DOI: 10.1021/Jo00040A064 |
0.296 |
|
| 2008 |
Zhang D, Pal A, Bornmann WG, Yamasaki F, Esteva FJ, Hortobagyi GN, Bartholomeusz C, Ueno NT. Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cells Molecular Cancer Therapeutics. 7: 1846-1850. PMID 18644997 DOI: 10.1158/1535-7163.Mct-08-0168 |
0.294 |
|
| 2003 |
Tanis KQ, Veach D, Duewel HS, Bornmann WG, Koleske AJ. Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Molecular and Cellular Biology. 23: 3884-96. PMID 12748290 DOI: 10.1128/Mcb.23.11.3884-3896.2003 |
0.294 |
|
| 2007 |
Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. The Journal of Clinical Investigation. 117: 3846-56. PMID 18060032 DOI: 10.1172/Jci31871 |
0.292 |
|
| 1994 |
Snyder L, Shen W, Bornmann WG, Danishefsky SJ. Synthesis of 18-Noranhydrocamptothecin Analogs Which Retain Topoisomerase I Inhibitory Function Journal of Organic Chemistry. 59: 7033-7037. DOI: 10.1021/Jo00102A030 |
0.292 |
|
| 2005 |
Wolff NC, Veach DR, Tong WP, Bornmann WG, Clarkson B, Ilaria RL. PD166326, a novel tyrosine kinase inhibitor, has greater antileukemic activity than imatinib mesylate in a murine model of chronic myeloid leukemia Blood. 105: 3995-4003. PMID 15657179 DOI: 10.1182/Blood-2004-09-3534 |
0.291 |
|
| 2010 |
Doubrovin M, Kochetkova T, Santos E, Veach DR, Smith-Jones P, Pillarsetty N, Balatoni J, Bornmann W, Gelovani J, Larson SM. (124)I-iodopyridopyrimidinone for PET of Abl kinase-expressing tumors in vivo. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 121-9. PMID 20048131 DOI: 10.2967/Jnumed.109.066126 |
0.289 |
|
| 2002 |
Nagar B, Bornmann WG, Pellicena P, Schindler T, Veach DR, Miller WT, Clarkson B, Kuriyan J. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Research. 62: 4236-43. PMID 12154025 DOI: 10.2210/Pdb1Iep/Pdb |
0.288 |
|
| 2014 |
Peng Z, Maxwell D, Sun D, Ying Y, Schuber PT, Bhanu Prasad BA, Gelovani J, Yung WK, Bornmann WG. Design and Synthesis of an Inositol Phosphate Analog Based on Computational Docking Studies. Tetrahedron. 70: 984-990. PMID 25110363 DOI: 10.1016/J.Tet.2013.11.092 |
0.288 |
|
| 2010 |
Blanco E, Bey EA, Khemtong C, Yang SG, Setti-Guthi J, Chen H, Kessinger CW, Carnevale KA, Bornmann WG, Boothman DA, Gao J. β-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy Cancer Research. 70: 3896-3904. PMID 20460521 DOI: 10.1158/0008-5472.Can-09-3995 |
0.287 |
|
| 2005 |
Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA. Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 3055-64. PMID 15837761 DOI: 10.1158/1078-0432.Ccr-04-2185 |
0.286 |
|
| 2012 |
García M, Cooper A, Shi W, Bornmann W, Carrion R, Kalman D, Nabel GJ. Productive replication of Ebola virus is regulated by the c-Abl1 tyrosine kinase. Science Translational Medicine. 4: 123ra24. PMID 22378924 DOI: 10.1126/Scitranslmed.3003500 |
0.285 |
|
| 2011 |
Reeves PM, Smith SK, Olson VA, Thorne SH, Bornmann W, Damon IK, Kalman D. Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases. Journal of Virology. 85: 21-31. PMID 20962097 DOI: 10.1128/Jvi.01814-10 |
0.284 |
|
| 2010 |
Robertson FM, Woodward WA, Pickei R, Ye Z, Bornmann W, Pal A, Peng Z, Hall CS, Cristofanilli M. Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids. Cancer. 116: 2760-7. PMID 20503408 DOI: 10.1002/Cncr.25176 |
0.28 |
|
| 2007 |
Mukhopadhyay U, Pal A, Gelovani JG, Bornmann W, Alauddin MM. Radiosynthesis of 2′-deoxy-2′-[18F]-fluoro-5-methyl-1-β-l-arabinofuranosyluracil ([18F]-l-FMAU) for PET Applied Radiation and Isotopes. 65: 941-946. PMID 17517516 DOI: 10.1016/J.Apradiso.2007.04.003 |
0.278 |
|
| 2005 |
Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Andreeff M. A Novel Mechanism of Action of Methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate (CDDO-Me): Direct Permeabilization of the Inner Mitochondrial Membrane To Inhibit Electron Transport and Induce Apoptosis. Blood. 106: 4462-4462. DOI: 10.1182/Blood.V106.11.4462.4462 |
0.274 |
|
| 2003 |
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100 |
0.272 |
|
| 2009 |
Dong Y, Chin SF, Blanco E, Bey EA, Kabbani W, Xie XJ, Bornmann WG, Boothman DA, Gao J. Intratumoral delivery of β-lapachone via polymer implants for prostate cancer therapy Clinical Cancer Research. 15: 131-139. PMID 19118040 DOI: 10.1158/1078-0432.Ccr-08-1691 |
0.271 |
|
| 2009 |
Lopez G, Liu J, Ren W, Wei W, Wang S, Lahat G, Zhu QS, Bornmann WG, McConkey DJ, Pollock RE, Lev DC. Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma Clinical Cancer Research. 15: 3472-3483. PMID 19417021 DOI: 10.1158/1078-0432.Ccr-08-2714 |
0.271 |
|
| 2006 |
Doubrovin M, Beresten T, Veach D, Namavari M, Balatoni J, Bornmann W, Guelovani J, Larson S. Detection of BCR-ABL expression in human CML model using radiolabeled analogue of ABL-protein kinase inhibitor and positron-emission tomography (PET) Biology of Blood and Marrow Transplantation. 12: 17. DOI: 10.1016/J.Bbmt.2005.11.056 |
0.271 |
|
| 2005 |
Reeves PM, Bommarius B, Lebeis S, McNulty S, Christensen J, Swimm A, Chahroudi A, Chavan R, Feinberg MB, Veach D, Bornmann W, Sherman M, Kalman D. Erratum: Corrigendum: Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases Nature Medicine. 11: 1361-1361. DOI: 10.1038/Nm1205-1361B |
0.271 |
|
| 2006 |
Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M. A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: Direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis Molecular Pharmacology. 69: 1182-1193. PMID 16410408 DOI: 10.1124/Mol.105.018051 |
0.27 |
|
| 2008 |
Sankaranarayanapillai M, Tong WP, Yuan Q, Bankson JA, Dafni H, Bornmann WG, Soghomonyan S, Pal A, Ramirez MS, Webb D, Kaluarachchi K, Gelovani JG, Ronen SM. Monitoring histone deacetylase inhibition in vivo: Noninvasive magnetic resonance spectroscopy method Molecular Imaging. 7: 92-100. PMID 18706291 DOI: 10.2310/7290.2008.0011 |
0.27 |
|
| 1992 |
Magee TV, Bornmann WG, Isaacs RCA, Danishefsky SJ. A straightforward route to functionalized intermediates containing the CD substructure of taxol. Journal of Organic Chemistry. 57: 3274-3276. DOI: 10.1021/Jo00038A008 |
0.267 |
|
| 1993 |
Queneau Y, Krol WJ, Bornmann WG, Danishefsky SJ. A ready synthesis of intermediates containing the A-ring substructure of taxol: a Diels-Alder route to the B-seco taxane series. [Erratum to document cited in CA117(3):26833h] The Journal of Organic Chemistry. 58: 798-798. DOI: 10.1021/Jo00055A048 |
0.265 |
|
| 2005 |
von Bubnoff N, Veach DR, van der Kuip H, Aulitzky WE, Sänger J, Seipel P, Bornmann WG, Peschel C, Clarkson B, Duyster J. A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor. Blood. 105: 1652-9. PMID 15459011 DOI: 10.1182/Blood-2004-06-2445 |
0.262 |
|
| 2012 |
Myers AL, Zhang YP, Kramer MA, Bornmann WG, Kaseb A, Yang P, Tran HT. A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone. Letters in Organic Chemistry. 9: 762-766. PMID 24883052 DOI: 10.2174/157017812803901890 |
0.261 |
|
| 2006 |
Apisarnthanarax S, Alauddin MM, Mourtada F, Ariga H, Raju U, Mawlawi O, Han D, Bornmann WG, Ajani JA, Milas L, Gelovani JG, Chao KSC. Early detection of chemoradioresponse in esophageal carcinoma by 3′-deoxy-3′-3H-fluorothymidine using preclinical tumor models Clinical Cancer Research. 12: 4590-4597. PMID 16899606 DOI: 10.1158/1078-0432.Ccr-05-2720 |
0.259 |
|
| 2013 |
Maxwell DS, Sun D, Peng Z, Martin DV, Bhanu Prasad BA, Bornmann WG. Synthesis of a Macrocycle Based on Linked Amino Acid Mimetics (LAAM). Tetrahedron Letters. 54: 5799-5801. PMID 25110365 DOI: 10.1016/J.Tetlet.2013.08.041 |
0.259 |
|
| 2004 |
Deckert PM, Bornmann WG, Ritter G, Williams C, Franke J, Keilholz U, Thiel E, Old LJ, Bertino JR, Welt S. Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine. International Journal of Oncology. 24: 1289-1295. PMID 15067353 DOI: 10.3892/Ijo.24.5.1289 |
0.257 |
|
| 2006 |
Pal A, Glekas A, Doubrovin M, Balatoni J, Namavari M, Beresten T, Maxwell D, Soghomonyan S, Shavrin A, Ageyeva L, Finn R, Larson SM, Bornmann W, Gelovani JG. Erratum: Molecular Imaging of EGFR Kinase Activity in Tumors with 124I-Labeled Small Molecular Tracer and Positron Emission Tomography (Mol Imaging Biol (2006) vol. 8 (5) (262-277) 10.1007/s11307-006-0049-0)) Molecular Imaging and Biology. 8. DOI: 10.1007/S11307-006-0067-Y |
0.255 |
|
| 1999 |
Byrd CA, Bornmann W, Erdjument-Bromage H, Tempst P, Pavletich N, Rosen N, Nathan CF, Ding A. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 96: 5645-50. PMID 10318938 DOI: 10.1073/Pnas.96.10.5645 |
0.254 |
|
| 2011 |
Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, et al. Synthesis and ex vivo autoradiographic evaluation of ethyl-β-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[18F]fluoro-β-D-glucopyranoside--a novel radioligand for lactose-binding protein: implications for early detection of pancreatic carcinomas with PET. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 13: 536-46. PMID 20593279 DOI: 10.1007/S11307-010-0334-9 |
0.252 |
|
| 2005 |
Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Boothman DA, Song CW. Susceptibility of cancer cells to β-lapachone is enhanced by ionizing radiation International Journal of Radiation Oncology Biology Physics. 61: 212-219. PMID 15629614 DOI: 10.1016/J.Ijrobp.2004.09.018 |
0.252 |
|
| 2000 |
Sabbatini PJ, Kudryashov V, Ragupathi G, Danishefsky SJ, Livingston PO, Bornmann W, Spassova M, Zatorski A, Spriggs D, Aghajanian C, Soignet S, Peyton M, O'Flaherty C, Curtin J, Lloyd KO. Immunization of ovarian cancer patients with a synthetic Lewis(y)-protein conjugate vaccine: a phase 1 trial. International Journal of Cancer. 87: 79-85. PMID 10861456 DOI: 10.1002/1097-0215(20000701)87:1<79::Aid-Ijc12>3.0.Co;2-L |
0.249 |
|
| 2008 |
Fernandez A, Sanguino A, Peng Z, Crespo A, Ozturk E, Zhang X, Wang S, Bornmann W, Lopez-Berestein G. Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target Aacr Education Book. 2008: 589-599. DOI: 10.1158/Aacr.Edb-Can-07-0345 |
0.249 |
|
| 2009 |
Najjar AM, Nishii R, Maxwell DS, Volgin A, Mukhopadhyay U, Bornmann WG, Tong W, Alauddin M, Gelovani JG. Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 50: 409-16. PMID 19223410 DOI: 10.2967/Jnumed.108.058735 |
0.248 |
|
| 2001 |
Li XK, Motwani M, Tong W, Bornmann W, Schwartz GK. Huanglian, A chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells. Molecular Pharmacology. 58: 1287-93. PMID 11093765 DOI: 10.1124/mol.58.6.1287 |
0.241 |
|
| 2005 |
Spees WM, Gade TPF, Yang G, Tong WP, Bornmann WG, Gorlick R, Koutcher JA. An 19F magnetic resonance-based in vivo assay of solid tumor methotrexate resistance: Proof of principle Clinical Cancer Research. 11: 1454-1461. PMID 15746046 DOI: 10.1158/1078-0432.Ccr-04-1439 |
0.239 |
|
| 2005 |
Spassova MK, Bornmann WG, Ragupathi G, Sukenick G, Livingston PO, Danishefsky SJ. Synthesis of selected LeY and KH-1 analogues: a medicinal chemistry approach to vaccine optimization. The Journal of Organic Chemistry. 70: 3383-95. PMID 15844973 DOI: 10.1021/Jo048016L |
0.234 |
|
| 1999 |
Ragupathi G, Slovin SF, Adluri S, Sames D, Kim IJ, Kim HM, Spassova M, Bornmann WG, Lloyd KO, Scher HI, Livingston PO, Danishefsky SJ. A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle. Angewandte Chemie (International Ed. in English). 38: 563-566. PMID 29711780 DOI: 10.1002/(Sici)1521-3773(19990215)38:4<563::Aid-Anie563>3.0.Co;2-3 |
0.233 |
|
| 2005 |
Veach DR, Namavari M, Beresten T, Balatoni J, Minchenko M, Djaballah H, Finn RD, Clarkson B, Gelovani JG, Bornmann WG, Larson SM. Synthesis and in vitro examination of [124I]-, [ 125I]- and [131I]-2-(4-iodophenylamino) pyrido[2,3-d]pyrimidin-7-one radiolabeled Abl kinase inhibitors Nuclear Medicine and Biology. 32: 313-321. PMID 15878500 DOI: 10.1016/J.Nucmedbio.2005.01.008 |
0.226 |
|
| 2009 |
Flores LG, Bertolini S, Yeh HH, Young D, Mukhopadhyay U, Pal A, Ying Y, Volgin A, Shavrin A, Soghomonyan S, Tong W, Bornmann W, Alauddin MM, Logsdon C, Gelovani JG. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT. Plos One. 4: e7977. PMID 19956730 DOI: 10.1371/Journal.Pone.0007977 |
0.224 |
|
| 2010 |
McNulty S, Bornmann W, Schriewer J, Werner C, Smith SK, Olson VA, Damon IK, Buller RM, Heuser J, Kalman D. Multiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesis. Plos One. 5: e10884. PMID 20526370 DOI: 10.1371/Journal.Pone.0010884 |
0.219 |
|
| 2002 |
Wisniewski D, Lambek CL, Liu C, Strife A, Veach DR, Nagar B, Young MA, Schindler T, Bornmann WG, Bertino JR, Kuriyan J, Clarkson B. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases Cancer Research. 62: 4244-4255. PMID 12154026 |
0.214 |
|
| 2000 |
Miyamoto S, Huang TT, Wuerzberger-Davis S, Bornmann WG, Pink JJ, Tagliarino C, Kinsella TJ, Boothman DA. Cellular and molecular responses to topoisomerase I poisons: Exploiting synergy for improved radiotherapy Annals of the New York Academy of Sciences. 922: 274-292. PMID 11193903 DOI: 10.1111/J.1749-6632.2000.Tb07045.X |
0.204 |
|
| 2004 |
Cherukuri A, Carter RH, Brooks S, Bornmann W, Finn R, Dowd CS, Pierce SK. B cell signaling is regulated by induced palmitoylation of CD81. The Journal of Biological Chemistry. 279: 31973-82. PMID 15161911 DOI: 10.1074/Jbc.M404410200 |
0.203 |
|
| 2003 |
von Bubnoff N, Veach DR, Miller WT, Li W, Sänger J, Peschel C, Bornmann WG, Clarkson B, Duyster J. Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors. Cancer Research. 63: 6395-404. PMID 14559829 |
0.197 |
|
| 1999 |
Ragupathi G, Slovin SF, Adluri S, Sames D, Kim IJ, Kim HM, Spassova M, Bornmann WG, Lloyd KO, Scher HI, Livingston PO, Danishefsky SJ. Ein totalsynthetischer Globo-H-Kohlenhydrat-Impfstoff verursacht eine gezielte humorale Immunantwort bei Prostatakrebs-Patienten: der Beweis des Prinzips Angewandte Chemie. 111: 590-594. DOI: 10.1002/(Sici)1521-3757(19990215)111:4<590::Aid-Ange590>3.0.Co;2-A |
0.194 |
|
| 2020 |
Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, ... ... Bornmann W, et al. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nature Metabolism. PMID 33230295 DOI: 10.1038/s42255-020-00313-3 |
0.185 |
|
| 1994 |
Bornmann WG. Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound Biochemistry®. 33: 12665-12675. PMID 7918493 DOI: 10.1021/Bi00208A018 |
0.182 |
|
| 2000 |
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science (New York, N.Y.). 289: 1938-42. PMID 10988075 DOI: 10.1126/Science.289.5486.1938 |
0.181 |
|
| 2005 |
Ough M, Lewis A, Bey EA, Gao J, Ritchie JM, Bornmann W, Boothman DA, Oberley LW, Cullen JJ. Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biology & Therapy. 4: 95-102. PMID 15662131 DOI: 10.4161/Cbt.4.1.1382 |
0.179 |
|
| 2003 |
Spees WM, Yang G, Veach D, Rubio MB, Koutcher JA, Bornmann W. A fluorine-labeled methotrexate as a probe for monitoring tumor antifolate pharmacokinetics: synthesis, in vitro cytotoxicity, and pilot in vivo 19F magnetic resonance spectra. Molecular Cancer Therapeutics. 2: 933-9. PMID 14578458 |
0.179 |
|
| 2004 |
Deng X, Hofmann ER, Villanueva A, Hobert O, Capodieci P, Veach DR, Yin X, Campodonico L, Glekas A, Cordon-Cardo C, Clarkson B, Bornmann WG, Fuks Z, Hengartner MO, Kolesnick R. Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation. Nature Genetics. 36: 906-12. PMID 15273685 DOI: 10.1038/Ng1396 |
0.179 |
|
| 2003 |
Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA. A new human peptide deformylase inhibitable by actinonin. Biochemical and Biophysical Research Communications. 312: 309-15. PMID 14637138 DOI: 10.1016/J.Bbrc.2003.10.123 |
0.178 |
|
| 1998 |
Wuerzberger SM, Pink JJ, Planchon SM, Byers KL, Bornmann WG, Boothman DA. Induction of apoptosis in MCF-7: WS8 breast cancer cells by β-Lapachone Cancer Research. 58: 1876-1885. PMID 9581828 |
0.172 |
|
| 2003 |
Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK. Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies. Molecular Cancer Therapeutics. 2: 1171-81. PMID 14617791 |
0.16 |
|
| 1992 |
Queneau Y, Krol WJ, Bornmann WG, Danishefsky SJ. A ready synthesis of intermediates containing the A-ring substructure of taxol: A Diels-Alder route to the B-seco taxane series Journal of Organic Chemistry. 57: 4043-4047. |
0.16 |
|
| 2011 |
Faderl S, Bueso-Ramos C, Liu Z, Pal A, Bornmann W, Ciurea DV, Harris D, Hazan-Halevy I, Kantarjian HM, Estrov Z. Kit inhibitor APcK110 extends survival in an AML xenograft mouse model Investigational New Drugs. 29: 1094-1097. PMID 20517635 DOI: 10.1007/s10637-010-9459-6 |
0.159 |
|
| 2004 |
Swimm A, Bommarius B, Li Y, Cheng D, Reeves P, Sherman M, Veach D, Bornmann W, Kalman D. Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals. Molecular Biology of the Cell. 15: 3520-9. PMID 15155808 DOI: 10.1091/Mbc.E04-02-0093 |
0.158 |
|
| 2015 |
Napier RJ, Norris BA, Swimm A, Giver CR, Harris WA, Laval J, Napier BA, Patel G, Crump R, Peng Z, Bornmann W, Pulendran B, Buller RM, Weiss DS, Tirouvanziam R, et al. Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity. Plos Pathogens. 11: e1004770. PMID 25822986 DOI: 10.1371/Journal.Ppat.1004770 |
0.158 |
|
| 1995 |
Prochaska HJ, Bornmann WG, Baron P, Polsky B. Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz Molecular Pharmacology. 48: 15-20. PMID 7542738 |
0.157 |
|
| 1999 |
Planchon SM, Wuerzberger-Davis SM, Pink JJ, Robertson KA, Bornmann WG, Boothman DA. Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells. Oncology Reports. 6: 485-492. PMID 10203579 DOI: 10.3892/Or.6.3.485 |
0.156 |
|
| 1994 |
Snyder L, Shen W, Bornmann WG, Danishefsky SJ. Synthesis of 18-noranhydrocamptothecin analogs which retain topoisomerase I inhibitory function Journal of Organic Chemistry. 59: 7033-7037. |
0.155 |
|
| 2001 |
Hofmann RM, Cotton GJ, Chang EJ, Vidal E, Veach D, Bornmann W, Muir TW. Fluorescent monitoring of kinase activity in real time: development of a robust fluorescence-based assay for Abl tyrosine kinase activity. Bioorganic & Medicinal Chemistry Letters. 11: 3091-4. PMID 11720849 DOI: 10.1016/S0960-894X(01)00650-3 |
0.152 |
|
| 2002 |
Mayer-Kuckuk P, Banerjee D, Malhotra S, Doubrovin M, Iwamoto M, Akhurst T, Balatoni J, Bornmann W, Finn R, Larson S, Fong Y, Gelovani Tjuvajev J, Blasberg R, Bertino JR. Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Proceedings of the National Academy of Sciences of the United States of America. 99: 3400-5. PMID 11891321 DOI: 10.1073/Pnas.062036899 |
0.151 |
|
| 2001 |
Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA. β-Lapachone-induced apoptosis in human prostate cancer cells: Involvement of NQO1/xip3 Experimental Cell Research. 267: 95-106. PMID 11412042 DOI: 10.1006/Excr.2001.5234 |
0.151 |
|
| 2003 |
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell. 112: 859-871. PMID 12654251 DOI: 10.1016/S0092-8674(03)00194-6 |
0.151 |
|
| 1998 |
Aschele C, Baldo C, Sobrero AF, Debernardis D, Bornmann WG, Bertino JR. Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro Clinical Cancer Research. 4: 1323-1330. PMID 9607593 |
0.145 |
|
| 2011 |
Napier RJ, Rafi W, Cheruvu M, Powell KR, Zaunbrecher MA, Bornmann W, Salgame P, Shinnick TM, Kalman D. Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis. Cell Host & Microbe. 10: 475-85. PMID 22100163 DOI: 10.1016/J.Chom.2011.09.010 |
0.145 |
|
| 2003 |
Koehne G, Doubrovin M, Doubrovina E, Zanzonico P, Gallardo HF, Ivanova A, Balatoni J, Teruya-Feldstein J, Heller G, May C, Ponomarev V, Ruan S, Finn R, Blasberg RG, Bornmann W, et al. Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes Nature Biotechnology. 21: 405-413. PMID 12652311 DOI: 10.1038/Nbt805 |
0.139 |
|
| 1995 |
Chavan SJ, Bornmann WG, Flexner C, Prochaska HJ. Inactivation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Oltipraz: Evidence for the Formation of a Stable Adduct Archives of Biochemistry and Biophysics. 324: 143-152. PMID 7503549 DOI: 10.1006/abbi.1995.9916 |
0.137 |
|
| 1996 |
Danishefsky SJ, Masters JJ, Young WB, Link JT, Snyder LB, Magee TV, Jung DK, Isaacs RCA, Bornmann WG, Alaimo CA, Coburn CA, Di Grandi MJ. Total synthesis of baccatin III and taxol Journal of the American Chemical Society. 118: 2843-2859. |
0.137 |
|
| 1984 |
Mundy BP, Bornmann WG. A simple synthesis of the multipurpose pheromone of Mus musculus Journal of Organic Chemistry. 49: 5264-5265. |
0.133 |
|
| 2004 |
Capiaux GM, Budak-Alpdogan T, Alpdogan O, Bornmann W, Takebe N, Banerjee D, Maley F, Bertino JR. Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene Cancer Gene Therapy. 11: 767-773. PMID 15359285 DOI: 10.1038/Sj.Cgt.7700683 |
0.132 |
|
| 2009 |
Edler MC, Yang G, Katherine Jung M, Bai R, Bornmann WG, Hamel E. Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity Archives of Biochemistry and Biophysics. 487: 98-104. PMID 19497297 DOI: 10.1016/j.abb.2009.05.014 |
0.132 |
|
| 1994 |
Joseph CK, Wright SD, Bornmann WG, Randolph JT, Kumar ER, Bittman R, Liu J, Kolesnick RN. Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells Journal of Biological Chemistry. 269: 17606-17610. PMID 8021269 |
0.131 |
|
| 2007 |
Bommarius B, Maxwell D, Swimm A, Leung S, Corbett A, Bornmann W, Kalman D. Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation. Molecular Microbiology. 63: 1748-68. PMID 17367393 DOI: 10.1111/J.1365-2958.2007.05626.X |
0.13 |
|
| 1993 |
Masters JJ, Jung DK, Bornmann WG, Danishefsky SJ, de Gala S. A concise synthesis of a highly functionalized C-aryl taxol analog by an intramolecular Heck olefination reaction Tetrahedron Letters. 34: 7253-7256. DOI: 10.1016/S0040-4039(00)79301-4 |
0.129 |
|
| 2014 |
Caruso JA, Campana R, Wei C, Su CH, Hanks AM, Bornmann WG, Keyomarsi K. Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells Cell Cycle. 13: 2587-2599. DOI: 10.4161/15384101.2015.942210 |
0.129 |
|
| 2020 |
Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, ... ... Bornmann W, et al. Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nature Metabolism. PMID 33340032 DOI: 10.1038/s42255-020-00335-x |
0.128 |
|
| 1978 |
Mundy BP, Bornmann WG. A novel entry into 3-acetylcyclohexanone via a cope rearrangement Tetrahedron Letters. 19: 957-960. DOI: 10.1016/S0040-4039(01)85424-1 |
0.124 |
|
| 1998 |
Parish CA, Dong JG, Bornmann WG, Chang J, Nakanishi K, Berova N. Circular dichroism studies of bisindole Vinca alkaloids Tetrahedron. 54: 15739-15758. DOI: 10.1016/S0040-4020(98)00988-0 |
0.124 |
|
| 2008 |
Nishii R, Volgin AY, Mawlawi O, Mukhopadhyay U, Pal A, Bornmann W, Gelovani JG, Alauddin MM. Evaluation of 2′-deoxy-2′-[18F]fluoro-5-methyl-1- β-l-arabinofuranosyluracil ([18F]-l-FMAU) as a PET imaging agent for cellular proliferation: Comparison with [18F]-d-FMAU and [ 18F]FLT European Journal of Nuclear Medicine and Molecular Imaging. 35: 990-998. PMID 18057932 DOI: 10.1007/s00259-007-0649-1 |
0.122 |
|
| 2013 |
Pal A, Peng Z, Schuber PT, Bhanu Prasad BA, Bornmann WG. Asymmetric synthesis of the C1-C6 portion of the psymberin using an Evans chiral auxiliary Tetrahedron Letters. 54: 5555-5557. DOI: 10.1016/j.tetlet.2013.05.153 |
0.12 |
|
| 1993 |
Shen W, Coburn CA, Bornmann WG, Danishefsky SJ. Concise total syntheses of dl-camptothecin and related anticancer drugs Journal of Organic Chemistry. 58: 611-617. |
0.118 |
|
| 1999 |
Depew KM, Marsden SP, Zatorska D, Zatorski A, Bornmann WG, Danishefsky SJ. Total synthesis of 5-N-acetylardeemin and amauromine: Practical routes to potential MDR reversal agents Journal of the American Chemical Society. 121: 11953-11963. DOI: 10.1021/ja991558d |
0.111 |
|
| 2001 |
Doubrovin M, Ponomarev V, Beresten T, Balatoni J, Bornmann W, Finn R, Humm J, Larson S, Sadelain M, Blasberg R, Tjuvajev JG. Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo Proceedings of the National Academy of Sciences of the United States of America. 98: 9300-9305. PMID 11481488 DOI: 10.1073/Pnas.161091198 |
0.106 |
|
| 2012 |
Nawrocki S, Kelly K, Espitia C, Bachier C, Bornmann W, Carew J. 529 Targeting SIRT1 Activity: a Novel Strategy for Acute Myeloid Leukemia Therapy European Journal of Cancer. 48: 163. DOI: 10.1016/S0959-8049(12)72326-2 |
0.105 |
|
| 2002 |
Hackman T, Doubrovin M, Balatoni J, Beresten T, Ponomarev V, Beattie B, Finn R, Bornmann W, Blasberg R, Tjuvajev JG. Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET. Molecular Imaging. 1: 36-42. PMID 12920859 DOI: 10.1162/153535002753395699 |
0.099 |
|
| 2004 |
Yuan RR, Wong P, McDevitt MR, Doubrovina E, Leiner I, Bornmann W, O'reilly R, Pamer EG, Scheinberg DA. Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers. Blood. 104: 2397-402. PMID 15217835 DOI: 10.1182/Blood-2004-01-0324 |
0.099 |
|
| 2004 |
Ponomarev V, Doubrovin M, Serganova I, Vider J, Shavrin A, Beresten T, Ivanova A, Ageyeva L, Tourkova V, Balatoni J, Bornmann W, Blasberg R, Gelovani Tjuvajev J. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. European Journal of Nuclear Medicine and Molecular Imaging. 31: 740-51. PMID 15014901 DOI: 10.1007/S00259-003-1441-5 |
0.095 |
|
| 2001 |
Liang X, Nazarian A, Erdjument-Bromage H, Bornmann W, Tempst P, Resh MD. Heterogeneous Fatty Acylation of Src Family Kinases with Polyunsaturated Fatty Acids Regulates Raft Localization and Signal Transduction Journal of Biological Chemistry. 276: 30987-30994. PMID 11423543 DOI: 10.1074/jbc.M104018200 |
0.094 |
|
| 1979 |
Lipkowitz KB, Scarpone S, Mundy BP, Bornmann WG. Formation and synthetic utility of dihydro- and dihydrothiapyrans Journal of Organic Chemistry. 44: 486-494. |
0.092 |
|
| 2001 |
Gilewski T, Ragupathi G, Bhuta S, Williams LJ, Musselli C, Zhang XF, Bornmann WG, Spassova M, Bencsath KP, Panageas KS, Chin J, Hudis CA, Norton L, Houghton AN, Livingston PO, et al. Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial. Proceedings of the National Academy of Sciences of the United States of America. 98: 3270-5. PMID 11248068 DOI: 10.1073/Pnas.051626298 |
0.091 |
|
| 2003 |
Ragupathi G, Koide F, Sathyan N, Kagan E, Spassova M, Bornmann W, Gregor P, Reis CA, Clausen H, Danishefsky SJ, Livingston PO. A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers. Cancer Immunology, Immunotherapy : Cii. 52: 608-16. PMID 12811527 DOI: 10.1007/s00262-003-0399-2 |
0.091 |
|
| 2002 |
Tjuvajev JG, Doubrovin M, Akhurst T, Cai S, Balatoni J, Alauddin MM, Finn R, Bornmann W, Thaler H, Conti PS, Blasberg RG. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression Journal of Nuclear Medicine. 43: 1072-1083. PMID 12163634 |
0.09 |
|
| 2003 |
Moresco EM, Scheetz AJ, Bornmann WG, Koleske AJ, Fitzsimonds RM. Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity. Journal of Neurophysiology. 89: 1678-87. PMID 12626632 DOI: 10.1152/jn.0892.2002 |
0.088 |
|
| 1999 |
Slovin SF, Ragupathi G, Adluri S, Ungers G, Terry K, Kim S, Spassova M, Bornmann WG, Fazzari M, Dantis L, Olkiewicz K, Lloyd KO, Livingston PO, Danishefsky SJ, Scher HI. Carbohydrate vaccines in cancer: Immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man Proceedings of the National Academy of Sciences of the United States of America. 96: 5710-5715. PMID 10318949 DOI: 10.1073/Pnas.96.10.5710 |
0.08 |
|
| 2002 |
Hackman T, Doubrovin M, Balatoni J, Beresten T, Ponomarev V, Beattie B, Finn R, Bornmann W, Blasberg R, Tjuvajev JG. Imaging Expression of Cytosine Deaminase-Herpes Virus Thymidine Kinase Fusion Gene (CD/TK) Expression with [
124
I]FIAU and PET Molecular Imaging. 1: 153535002002000. DOI: 10.1162/15353500200200003 |
0.077 |
|
| 2004 |
Larson SM, Morris M, Gunther I, Beattie B, Humm JL, Akhurst TA, Finn RD, Erdi Y, Pentlow K, Dyke J, Squire O, Bornmann W, McCarthy T, Welch M, Scher H. Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 45: 366-73. PMID 15001675 |
0.076 |
|
| 2003 |
Nasongkla N, Wiedmann AF, Bruening A, Beman M, Ray D, Bornmann WG, Boothman DA, Gao J. Enhancement of Solubility and Bioavailability of β-Lapachone Using Cyclodextrin Inclusion Complexes Pharmaceutical Research. 20: 1626-1633. PMID 14620518 DOI: 10.1023/A:1026143519395 |
0.075 |
|
| 1997 |
Kothari PJ, Finn RD, Bornmann WG, Agus DB, Vera JC, Larson SM. Chemical Consequences Resulting from Multi-millicurie Preparation of 6-[18F]-Fluoro-6-deoxy-L-ascorbic Acid Radiochimica Acta. 77: 87-90. |
0.074 |
|
| 2002 |
Ragupathi G, Cappello S, Yi SS, Canter D, Spassova M, Bornmann WG, Danishefsky SJ, Livingston PO. Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines Vaccine. 20: 1030-1038. PMID 11803062 DOI: 10.1016/S0264-410X(01)00451-0 |
0.071 |
|
| 1999 |
Ragupathi G, Slovin SF, Adluri S, Sames D, Kim IJ, Kim HM, Spassova M, Bornmann WG, Lloyd KO, Scher HI, Livingston PO, Danishefsky SJ. A fully synthetic globo H carbohydrate vaccine induces a focused humoral response in prostate cancer patients: A proof of principle Angewandte Chemie - International Edition. 38: 563-566. |
0.063 |
|
| 1996 |
Dong JG, Bornmann W, Nakanishi K, Berova N. Structural studies of vinblastine alkaloids by exciton coupled circular dichroism. Phytochemistry. 40: 1821-4. PMID 8590642 DOI: 10.1016/0031-9422(95)00627-J |
0.063 |
|
| 2000 |
Wang ZG, Williams LJ, Zhang XF, Zatorski A, Kudryashov V, Ragupathi G, Spassova M, Bornmann W, Slovin SF, Scher HI, Livingston PO, Lloyd KO, Danishefsky SJ. Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens. Proceedings of the National Academy of Sciences of the United States of America. 97: 2719-24. PMID 10716997 DOI: 10.1073/Pnas.97.6.2719 |
0.058 |
|
| 2012 |
Myers AL, Zhang YP, Kramer MA, Bornmann WG, Kaseb A, Yang P, Tran HT. A practical synthesis and X-ray crystallographic analysis of dithymoquinone, a photodimer of thymoquinone Letters in Organic Chemistry. 9: 762-766. |
0.058 |
|
| 1992 |
Magee TV, Bornmann WG, Isaacs RCA, Danishefsky SJ. A straightforward route to functionalized intermediates containing the CD substructure of taxol Journal of Organic Chemistry. 57: 3274-3276. |
0.05 |
|
| 1978 |
Mundy BP, Bornmann WG. The apparatus and procedure for cope rearrangement of the pyrrolidino enamine of 2-acetyl-6-methyl-3,4-dehydro[2h]pyran Synthetic Communications. 8: 227-230. DOI: 10.1080/00397917808065613 |
0.049 |
|
| 1999 |
Kothari PJ, Bornmann WG, Finn RD, Balatoni JA, Larson SM. Preparation of no-carrier-added 131I-labelled-3'-iodoaminopterin and 3'-iodomethotrexate Journal of Labelled Compounds and Radiopharmaceuticals. 42: S771-S773. |
0.037 |
|
| 2000 |
Sanchez-Carbayo M, Bornmann W, Cordon-Cardo C. DNA Microchips: Technical and Practical Considerations Current Organic Chemistry. 4: 945-971. DOI: 10.2174/1385272003375987 |
0.01 |
|
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