Douglas S. Clark - Publications

Chemistry University of California, Berkeley, Berkeley, CA 
Biochemical engineering and biocatalysis

183 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Muckom R, Bao X, Tran E, Chen E, Murugappan A, Dordick JS, Clark DS, Schaffer DV. High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates. Science Advances. 6: eaaz1457. PMID 32821815 DOI: 10.1126/Sciadv.Aaz1457  1
2020 Whitehead TA, Banta S, Bentley WE, Betenbaugh MJ, Chan C, Clark DS, Hoesli CA, Jewett MC, Junker B, Koffas M, Kshirsagar R, Lewis A, Li CT, Maranas C, Terry Papoutsakis E, et al. The Importance and Future of Biochemical Engineering. Biotechnology and Bioengineering. PMID 32343367 DOI: 10.1002/Bit.27364  1
2018 Nierode GJ, Gopal S, Kwon P, Clark DS, Schaffer DV, Dordick JS. High-throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture. Biotechnology and Bioengineering. PMID 30229860 DOI: 10.1002/Bit.26839  1
2018 Muckom R, McFarland S, Yang C, Perea B, Gentes M, Murugappan A, Tran E, Dordick JS, Clark DS, Schaffer DV. High-Throughput Combinatorial Screening Reveals Interactions Between Signaling Molecules that Regulate Adult Neural Stem Cell Fate. Biotechnology and Bioengineering. PMID 30102775 DOI: 10.1002/Bit.26815  1
2017 Wu VW, Dana CM, Iavarone AT, Clark DS, Glass NL. Identification of Glutaminyl Cyclase Genes Involved in Pyroglutamate Modification of Fungal Lignocellulolytic Enzymes. Mbio. 8. PMID 28096492 DOI: 10.1128/Mbio.02231-16  0.92
2016 Nierode GJ, Perea BC, McFarland SK, Pascoal JF, Clark DS, Schaffer DV, Dordick JS. High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform. Stem Cell Reports. 7: 970-982. PMID 28157485 DOI: 10.1016/J.Stemcr.2016.10.001  1
2016 Glover DJ, Giger L, Kim SS, Naik RR, Clark DS. Geometrical assembly of ultrastable protein templates for nanomaterials. Nature Communications. 7: 11771. PMID 27249579 DOI: 10.1038/Ncomms11771  1
2016 Baer ZC, Bormann S, Sreekumar S, Grippo A, Toste FD, Blanch HW, Clark DS. Co-production of acetone and ethanol with molar ratio control enables production of improved gasoline or jet fuel blends. Biotechnology and Bioengineering. PMID 26987294 DOI: 10.1002/Bit.25978  1
2016 Wolski PW, Dana CM, Clark DS, Blanch HW. Engineering ionic liquid-tolerant cellulases for biofuels production. Protein Engineering, Design & Selection : Peds. PMID 26819239 DOI: 10.1093/Protein/Gzv066  1
2015 Carrico ZM, Strobel KL, Atreya ME, Clark DS, Francis MB. Simultaneous selection and counter-selection for the directed evolution of proteases in E. coli using a cytoplasmic anchoring strategy. Biotechnology and Bioengineering. PMID 26666461 DOI: 10.1002/Bit.25904  1
2015 Strobel KL, Pfeiffer KA, Blanch HW, Clark DS. Engineering Cel7A Carbohydrate Binding Module and Linker for Reduced Lignin Inhibition. Biotechnology and Bioengineering. PMID 26616493 DOI: 10.1002/Bit.25889  1
2015 Atreya ME, Strobel KL, Clark DS. Alleviating product inhibition in cellulase enzyme Cel7A. Biotechnology and Bioengineering. PMID 26302366 DOI: 10.1002/Bit.25809  1
2015 Strobel KL, Pfeiffer KA, Blanch HW, Clark DS. Structural insights into the affinity of Cel7A carbohydrate-binding module for lignin. The Journal of Biological Chemistry. 290: 22818-26. PMID 26209638 DOI: 10.1074/Jbc.M115.673467  1
2015 Pfeiffer KA, Sorek H, Roche CM, Strobel KL, Blanch HW, Clark DS. Evaluating endoglucanase Cel7B-lignin interaction mechanisms and kinetics using quartz crystal microgravimetry. Biotechnology and Bioengineering. 112: 2256-66. PMID 25994114 DOI: 10.1002/Bit.25657  1
2015 Chokhawala HA, Roche CM, Kim TW, Atreya ME, Vegesna N, Dana CM, Blanch HW, Clark DS. Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures. Bmc Biotechnology. 15: 11. PMID 25879765 DOI: 10.1186/S12896-015-0118-Z  1
2015 Sreekumar S, Baer ZC, Pazhamalai A, Gunbas G, Grippo A, Blanch HW, Clark DS, Toste FD. Production of an acetone-butanol-ethanol mixture from Clostridium acetobutylicum and its conversion to high-value biofuels. Nature Protocols. 10: 528-37. PMID 25719271 DOI: 10.1038/Nprot.2015.029  1
2015 Glover DJ, Clark DS. Oligomeric assembly is required for chaperone activity of the filamentous γ-prefoldin Febs Journal. DOI: 10.1111/febs.13341  1
2015 Shin C, Baer ZC, Chen XC, Ozcam AE, Clark DS, Balsara NP. Block copolymer pervaporation membrane for in situ product removal during acetone-butanol-ethanol fermentation Journal of Membrane Science. 484: 57-63. DOI: 10.1016/J.Memsci.2015.03.005  1
2014 Bormann S, Baer ZC, Sreekumar S, Kuchenreuther JM, Dean Toste F, Blanch HW, Clark DS. Engineering Clostridium acetobutylicum for production of kerosene and diesel blendstock precursors. Metabolic Engineering. 25: 124-30. PMID 25046159 DOI: 10.1016/J.Ymben.2014.07.003  1
2014 Sreekumar S, Baer ZC, Gross E, Padmanaban S, Goulas K, Gunbas G, Alayoglu S, Blanch HW, Clark DS, Toste FD. Chemocatalytic upgrading of tailored fermentation products toward biodiesel. Chemsuschem. 7: 2445-8. PMID 25044817 DOI: 10.1002/Cssc.201402244  1
2014 Kwon SJ, Lee DW, Shah DA, Ku B, Jeon SY, Solanki K, Ryan JD, Clark DS, Dordick JS, Lee MY. High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening. Nature Communications. 5: 3739. PMID 24799042 DOI: 10.1038/Ncomms4739  1
2014 Piao H, Froula J, Du C, Kim TW, Hawley ER, Bauer S, Wang Z, Ivanova N, Clark DS, Klenk HP, Hess M. Identification of novel biomass-degrading enzymes from genomic dark matter: Populating genomic sequence space with functional annotation. Biotechnology and Bioengineering. 111: 1550-65. PMID 24728961 DOI: 10.1002/Bit.25250  1
2014 Roche CM, Glass NL, Blanch HW, Clark DS. Engineering the filamentous fungus Neurospora crassa for lipid production from lignocellulosic biomass. Biotechnology and Bioengineering. 111: 1097-107. PMID 24700367 DOI: 10.1002/Bit.25211  1
2014 Dana CM, Dotson-Fagerstrom A, Roche CM, Kal SM, Chokhawala HA, Blanch HW, Clark DS. The importance of pyroglutamate in cellulase Cel7A. Biotechnology and Bioengineering. 111: 842-7. PMID 24375151 DOI: 10.1002/Bit.25178  1
2014 Pavlovich MJ, Clark DS, Graves DB. Quantification of air plasma chemistry for surface disinfection Plasma Sources Science and Technology. 23. DOI: 10.1088/0963-0252/23/6/065036  1
2014 Glover D, Giger L, Reese H, Clark DS. Engineering the self-assembly of ultrastable protein filaments into 2D and 3D multifunctional nanostructures Nanoscale Science and Engineering Forum 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 44.  1
2013 Roche CM, Blanch HW, Clark DS, Glass NL. Physiological role of Acyl coenzyme A synthetase homologs in lipid metabolism in Neurospora crassa. Eukaryotic Cell. 12: 1244-57. PMID 23873861 DOI: 10.1128/Ec.00079-13  1
2013 Fox JM, Jess P, Jambusaria RB, Moo GM, Liphardt J, Clark DS, Blanch HW. A single-molecule analysis reveals morphological targets for cellulase synergy. Nature Chemical Biology. 9: 356-61. PMID 23563526 DOI: 10.1038/Nchembio.1227  1
2013 Glover DJ, Giger L, Kim JR, Clark DS. Engineering protein filaments with enhanced thermostability for nanomaterials. Biotechnology Journal. 8: 228-36. PMID 22965482 DOI: 10.1002/Biot.201200009  1
2013 Schneider E, Clark DS. Cytochrome P450 (CYP) enzymes and the development of CYP biosensors. Biosensors & Bioelectronics. 39: 1-13. PMID 22809523 DOI: 10.1016/J.Bios.2012.05.043  1
2013 Pavlovich MJ, Chang HW, Sakiyama Y, Clark DS, Graves DB. Ozone correlates with antibacterial effects from indirect air dielectric barrier discharge treatment of water Journal of Physics D: Applied Physics. 46. DOI: 10.1088/0022-3727/46/14/145202  1
2013 Wilson DC, Aragonez RJ, Archuleta TN, Atkinson DP, Barrios MA, Batha SH, Bower DE, Bradley DK, Buckles RA, Clark DD, Clark DS, Clark DJ, Cradick JR, Danly CR, Day RD, et al. Comparing neutron and X-ray images from NIF implosions Epj Web of Conferences. 59. DOI: 10.1051/epjconf/20135904002  0.44
2013 Pavlovich MJ, Sakiyama Y, Clark DS, Graves DB. Antimicrobial synergy between ambient-gas plasma and UVA treatment of aqueous solution Plasma Processes and Polymers. 10: 1051-1060. DOI: 10.1002/Ppap.201300065  1
2013 Pavlovich MJ, Chen Z, Sakiyama Y, Clark DS, Graves DB. Effect of discharge parameters and surface characteristics on ambient-gas plasma disinfection Plasma Processes and Polymers. 10: 69-76. DOI: 10.1002/Ppap.201200073  1
2012 Anbarasan P, Baer ZC, Sreekumar S, Gross E, Binder JB, Blanch HW, Clark DS, Toste FD. Integration of chemical catalysis with extractive fermentation to produce fuels. Nature. 491: 235-9. PMID 23135469 DOI: 10.1038/Nature11594  1
2012 Shill K, Miller K, Clark DS, Blanch HW. A model for optimizing the enzymatic hydrolysis of ionic liquid-pretreated lignocellulose. Bioresource Technology. 126: 290-7. PMID 23079416 DOI: 10.1016/J.Biortech.2012.08.062  1
2012 Meli L, Jordan ET, Clark DS, Linhardt RJ, Dordick JS. Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems. Biomaterials. 33: 9087-96. PMID 22998815 DOI: 10.1016/J.Biomaterials.2012.08.065  1
2012 Huffer S, Roche CM, Blanch HW, Clark DS. Escherichia coli for biofuel production: bridging the gap from promise to practice. Trends in Biotechnology. 30: 538-45. PMID 22921756 DOI: 10.1016/J.Tibtech.2012.07.002  1
2012 Clark DS, Blanch HW, Wang DI, Demain AL, Wandrey C, Hu WS, Schultz JS, Shuler ML, Hoare M, Lightfoot EN, Humphrey AE, Dordick JS, Asenjo JA. Elmer L. Gaden, Jr. Tribute. Biotechnology and Bioengineering. 109: 2417-21. PMID 22910882 DOI: 10.1002/Bit.24610  1
2012 Dana CM, Saija P, Kal SM, Bryan MB, Blanch HW, Clark DS. Biased clique shuffling reveals stabilizing mutations in cellulase Cel7A. Biotechnology and Bioengineering. 109: 2710-9. PMID 22887329 DOI: 10.1002/Bit.24708  1
2012 Carrico ZM, Farkas ME, Zhou Y, Hsiao SC, Marks JD, Chokhawala H, Clark DS, Francis MB. N-Terminal labeling of filamentous phage to create cancer marker imaging agents. Acs Nano. 6: 6675-80. PMID 22830952 DOI: 10.1021/Nn301134Z  1
2012 Liszka MJ, Clark ME, Schneider E, Clark DS. Nature versus nurture: developing enzymes that function under extreme conditions. Annual Review of Chemical and Biomolecular Engineering. 3: 77-102. PMID 22468597 DOI: 10.1146/Annurev-Chembioeng-061010-114239  1
2012 Fox JM, Levine SE, Blanch HW, Clark DS. An evaluation of cellulose saccharification and fermentation with an engineered Saccharomyces cerevisiae capable of cellobiose and xylose utilization. Biotechnology Journal. 7: 361-73. PMID 22228702 DOI: 10.1002/Biot.201100209  1
2012 Fox JM, Levine SE, Clark DS, Blanch HW. Initial- and processive-cut products reveal cellobiohydrolase rate limitations and the role of companion enzymes. Biochemistry. 51: 442-52. PMID 22103405 DOI: 10.1021/Bi2011543  1
2012 Xin Q, Pfeiffer K, Prausnitz JM, Clark DS, Blanch HW. Extraction of lignins from aqueous-ionic liquid mixtures by organic solvents. Biotechnology and Bioengineering. 109: 346-52. PMID 22095406 DOI: 10.1002/Bit.24337  1
2012 Padmanabhan S, Zaia E, Wu K, Blanch HW, Clark DS, Bell AT, Prausnitz JM. Delignification of Miscanthus by Extraction Separation Science and Technology. 47: 370-376. DOI: 10.1080/01496395.2011.629639  1
2011 Bruns N, Clark DS. Self-Reporting Materials: Protein- Mediated Visual Indication of Damage in a Bulk Polymer. Chimia. 65: 245-249. PMID 28982404 DOI: 10.2533/Chimia.2011.245  1
2011 Kim TW, Chokhawala HA, Hess M, Dana CM, Baer Z, Sczyrba A, Rubin EM, Blanch HW, Clark DS. High-throughput in vitro glycoside hydrolase (HIGH) screening for enzyme discovery. Angewandte Chemie (International Ed. in English). 50: 11215-8. PMID 21922616 DOI: 10.1002/Anie.201104685  1
2011 Huffer S, Clark ME, Ning JC, Blanch HW, Clark DS. Role of alcohols in growth, lipid composition, and membrane fluidity of yeasts, bacteria, and archaea. Applied and Environmental Microbiology. 77: 6400-8. PMID 21784917 DOI: 10.1128/Aem.00694-11  1
2011 Traylor MJ, Ryan JD, Arnon ES, Dordick JS, Clark DS. Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometry. Journal of the American Chemical Society. 133: 14476-9. PMID 21766815 DOI: 10.1021/Ja203172C  1
2011 Graham JE, Clark ME, Nadler DC, Huffer S, Chokhawala HA, Rowland SE, Blanch HW, Clark DS, Robb FT. Identification and characterization of a multidomain hyperthermophilic cellulase from an archaeal enrichment. Nature Communications. 2: 375. PMID 21730956 DOI: 10.1038/Ncomms1373  1
2011 Levine SE, Fox JM, Clark DS, Blanch HW. A mechanistic model for rational design of optimal cellulase mixtures. Biotechnology and Bioengineering. 108: 2561-70. PMID 21702033 DOI: 10.1002/Bit.23249  1
2011 Bruns N, Clark DS. Self-reporting materials: protein-mediated visual indication of damage in a bulk polymer. Chimia. 65: 245-9. PMID 21678771 DOI: 10.2533/chimia.2011.245  1
2011 Trinh CT, Li J, Blanch HW, Clark DS. Redesigning Escherichia coli metabolism for anaerobic production of isobutanol. Applied and Environmental Microbiology. 77: 4894-904. PMID 21642415 DOI: 10.1128/Aem.00382-11  1
2011 Hess M, Sczyrba A, Egan R, Kim TW, Chokhawala H, Schroth G, Luo S, Clark DS, Chen F, Zhang T, Mackie RI, Pennacchio LA, Tringe SG, Visel A, Woyke T, et al. Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (New York, N.Y.). 331: 463-7. PMID 21273488 DOI: 10.1126/Science.1200387  1
2011 Shill K, Padmanabhan S, Xin Q, Prausnitz JM, Clark DS, Blanch HW. Ionic liquid pretreatment of cellulosic biomass: enzymatic hydrolysis and ionic liquid recycle. Biotechnology and Bioengineering. 108: 511-20. PMID 21246505 DOI: 10.1002/bit.23014  1
2011 Traylor MJ, Chai J, Clark DS. Simultaneous measurement of CYP1A2 activity, regioselectivity, and coupling: Implications for environmental sensitivity of enzyme-substrate binding. Archives of Biochemistry and Biophysics. 505: 186-93. PMID 20933493 DOI: 10.1016/J.Abb.2010.10.002  1
2011 Traylor MJ, Pavlovich MJ, Karim S, Hait P, Sakiyama Y, Clark DS, Graves DB. Long-term antibacterial efficacy of air plasma-activated water Journal of Physics D: Applied Physics. 44. DOI: 10.1088/0022-3727/44/47/472001  1
2011 Wolski PW, Clark DS, Blanch HW. Green fluorescent protein as a screen for enzymatic activity in ionic liquid-aqueous systems for in situ hydrolysis of lignocellulose Green Chemistry. 13: 3107-3110. DOI: 10.1039/C1Gc15691H  1
2010 Holder PG, Finley DT, Stephanopoulos N, Walton R, Clark DS, Francis MB. Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir : the Acs Journal of Surfaces and Colloids. 26: 17383-8. PMID 20964388 DOI: 10.1021/La1039305  1
2010 Clark DS. Protein melts: A new phase for protein chemistry. Nature Chemistry. 2: 607-8. PMID 20651715 DOI: 10.1038/Nchem.746  1
2010 Kim TW, Chokhawala HA, Nadler DC, Nadler D, Blanch HW, Clark DS. Binding modules alter the activity of chimeric cellulases: Effects of biomass pretreatment and enzyme source. Biotechnology and Bioengineering. 107: 601-11. PMID 20623472 DOI: 10.1002/Bit.22856  1
2010 Trinh CT, Huffer S, Clark ME, Blanch HW, Clark DS. Elucidating mechanisms of solvent toxicity in ethanologenic Escherichia coli. Biotechnology and Bioengineering. 106: 721-30. PMID 20564611 DOI: 10.1002/Bit.22743  1
2010 Levine SE, Fox JM, Blanch HW, Clark DS. A mechanistic model of the enzymatic hydrolysis of cellulose. Biotechnology and Bioengineering. 107: 37-51. PMID 20506540 DOI: 10.1002/Bit.22789  1
2010 Lee MY, Dordick JS, Clark DS. Metabolic enzyme microarray coupled with miniaturized cell-culture array technology for high-throughput toxicity screening. Methods in Molecular Biology (Clifton, N.J.). 632: 221-37. PMID 20217581 DOI: 10.1007/978-1-60761-663-4_14  1
2010 Akbar U, Shin DS, Schneider E, Dordick JS, Clark DS. Two-Step Enzymatic Modification of Solid-Supported Bergenin in Aqueous and Organic Media. Tetrahedron Letters. 51: 1220. PMID 20174610 DOI: 10.1016/J.Tetlet.2009.12.119  1
2010 Fernandes TG, Kwon SJ, Bale SS, Lee MY, Diogo MM, Clark DS, Cabral JM, Dordick JS. Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnology and Bioengineering. 106: 106-18. PMID 20069558 DOI: 10.1002/Bit.22661  1
2009 Whitehead TA, Bergeron LM, Clark DS. Tying up the loose ends: circular permutation decreases the proteolytic susceptibility of recombinant proteins. Protein Engineering, Design & Selection : Peds. 22: 607-13. PMID 19622546 DOI: 10.1093/Protein/Gzp034  1
2009 Sukumaran SM, Potsaid B, Lee MY, Clark DS, Dordick JS. Development of a fluorescence-based, ultra high-throughput screening platform for nanoliter-scale cytochrome p450 microarrays. Journal of Biomolecular Screening. 14: 668-78. PMID 19525490 DOI: 10.1177/1087057109336592  1
2009 Slocik JM, Kim SN, Whitehead TA, Clark DS, Naik RR. Biotemplated metal nanowires using hyperthermophilic protein filaments. Small (Weinheim An Der Bergstrasse, Germany). 5: 2038-42. PMID 19517487 DOI: 10.1002/Smll.200900499  1
2009 Bruns N, Pustelny K, Bergeron LM, Whitehead TA, Clark DS. Mechanical nanosensor based on FRET within a thermosome: damage-reporting polymeric materials. Angewandte Chemie (International Ed. in English). 48: 5666-9. PMID 19402088 DOI: 10.1002/Anie.200900554  1
2009 Fernandes TG, Diogo MM, Clark DS, Dordick JS, Cabral JM. High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends in Biotechnology. 27: 342-9. PMID 19398140 DOI: 10.1016/J.Tibtech.2009.02.009  1
2009 Hudson EP, Eppler RK, Beaudoin JM, Dordick JS, Reimer JA, Clark DS. Active-site motions and polarity enhance catalytic turnover of hydrated subtilisin dissolved in organic solvents. Journal of the American Chemical Society. 131: 4294-300. PMID 19317505 DOI: 10.1021/Ja806996Q  1
2009 Whitehead TA, Je E, Clark DS. Rational shape engineering of the filamentous protein gamma prefoldin through incremental gene truncation. Biopolymers. 91: 496-503. PMID 19189379 DOI: 10.1002/Bip.21157  1
2009 Bergeron LM, Gomez L, Whitehead TA, Clark DS. Self-renaturing enzymes: design of an enzyme-chaperone chimera as a new approach to enzyme stabilization. Biotechnology and Bioengineering. 102: 1316-22. PMID 19170240 DOI: 10.1002/Bit.22254  1
2009 Bergeron LM, Shis DL, Gomez L, Clark DS. Small molecule inhibition of a Group II chaperonin: pinpointing a loop region within the equatorial domain as necessary for protein refolding. Archives of Biochemistry and Biophysics. 481: 45-51. PMID 18976628 DOI: 10.1016/J.Abb.2008.10.016  1
2009 Bergeron LM, Tokatlian T, Gomez L, Clark DS. Redirecting the inactivation pathway of penicillin amidase and increasing amoxicillin production via a thermophilic molecular chaperone. Biotechnology and Bioengineering. 102: 417-24. PMID 18846552 DOI: 10.1002/Bit.22142  1
2009 Kumar RA, Papaïconomou N, Lee JM, Salminen J, Clark DS, Prausnitz JM. In vitro cytotoxicities of ionic liquids: effect of cation rings, functional groups, and anions. Environmental Toxicology. 24: 388-95. PMID 18825729 DOI: 10.1002/Tox.20443  1
2008 Brooks SJ, Coulombel L, Ahuja D, Clark DS, Dordick JS. Expanding the Scope of Biocatalysis: Oxidative Biotransformations on Solid-Supported Substrates. Advanced Synthesis & Catalysis. 350: 1517-1525. PMID 21881621 DOI: 10.1002/Adsc.200800188  1
2008 Eppler RK, Hudson EP, Chase SD, Dordick JS, Reimer JA, Clark DS. Biocatalyst activity in nonaqueous environments correlates with centisecond-range protein motions. Proceedings of the National Academy of Sciences of the United States of America. 105: 15672-7. PMID 18840689 DOI: 10.1073/Pnas.0804566105  1
2008 Ryan JD, Fish RH, Clark DS. Engineering cytochrome P450 enzymes for improved activity towards biomimetic 1,4-NADH cofactors. Chembiochem : a European Journal of Chemical Biology. 9: 2579-82. PMID 18816544 DOI: 10.1002/Cbic.200800246  1
2008 Fernandes TG, Kwon SJ, Lee MY, Clark DS, Cabral JM, Dordick JS. On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins. Analytical Chemistry. 80: 6633-9. PMID 18656951 DOI: 10.1021/Ac800848J  1
2008 Whitehead TA, Meadows AL, Clark DS. Controlling the self-assembly of a filamentous hyperthermophilic chaperone by an engineered capping protein. Small (Weinheim An Der Bergstrasse, Germany). 4: 956-60. PMID 18576281 DOI: 10.1002/Smll.200700848  1
2008 Bergeron LM, Lee C, Clark DS. Identification of a critical chaperoning region on an archaeal recombinant thermosome. Biochemical and Biophysical Research Communications. 369: 707-11. PMID 18313393 DOI: 10.1016/J.Bbrc.2008.02.103  1
2008 Meadows AL, Kong B, Berdichevsky M, Roy S, Rosiva R, Blanch HW, Clark DS. Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cells. Biotechnology Progress. 24: 334-41. PMID 18307352 DOI: 10.1021/Bp070301D  1
2008 Lee MY, Kumar RA, Sukumaran SM, Hogg MG, Clark DS, Dordick JS. Three-dimensional cellular microarray for high-throughput toxicology assays. Proceedings of the National Academy of Sciences of the United States of America. 105: 59-63. PMID 18160535 DOI: 10.1073/Pnas.0708756105  1
2008 Bergeron LM, Lee C, Tokatlian T, Höllrigl V, Clark DS. Chaperone function in organic co-solvents: experimental characterization and modeling of a hyperthermophilic chaperone subunit from Methanocaldococcus jannaschii. Biochimica Et Biophysica Acta. 1784: 368-78. PMID 18154740 DOI: 10.1016/J.Bbapap.2007.11.011  1
2008 Ryan JD, Clark DS. P450cam biocatalysis in surfactant-stabilized two-phase emulsions. Biotechnology and Bioengineering. 99: 1311-9. PMID 18098319 DOI: 10.1002/Bit.21772  1
2008 Córdova J, Ryan JD, Boonyaratanakornkit BB, Clark DS. Esterase activity of bovine serum albumin up to 160 °C: A new benchmark for biocatalysis Enzyme and Microbial Technology. 42: 278-283. DOI: 10.1016/J.Enzmictec.2007.10.007  1
2008 Asuri P, Lee MY, Ramasubramanian AK, Hogg M, Eker B, Butt S, Ryan J, Sukumaran S, Clark DS, Dordick JS. Microarray biochips for high-throughput drug screening Aiche Annual Meeting, Conference Proceedings 1
2008 Sukumaran S, Lee MY, Potsaid B, Clark DS, Dordick JS. Screening tools for the high-throughput analysis of CYP450-mediated drug metabolism and CYP450 inhibition Aiche Annual Meeting, Conference Proceedings 1
2007 Logan TC, Clark DS, Stachowiak TB, Svec F, Fréchet JM. Photopatterning enzymes on polymer monoliths in microfluidic devices for steady-state kinetic analysis and spatially separated multi-enzyme reactions. Analytical Chemistry. 79: 6592-8. PMID 17658765 DOI: 10.1021/Ac070705K  1
2007 Meadows AL, Roy S, Clark DS, Blanch HW. Optimal design of metabolic flux analysis experiments for anchorage-dependent mammalian cells using a cellular automaton model. Biotechnology and Bioengineering. 98: 221-9. PMID 17657779 DOI: 10.1002/Bit.21414  1
2007 Whitehead TA, Boonyaratanakornkit BB, Höllrigl V, Clark DS. A filamentous molecular chaperone of the prefoldin family from the deep-sea hyperthermophile Methanocaldococcus jannaschii. Protein Science : a Publication of the Protein Society. 16: 626-34. PMID 17384227 DOI: 10.1110/Ps.062599907  1
2007 Boonyaratanakornkit BB, Miao LY, Clark DS. Transcriptional responses of the deep-sea hyperthermophile Methanocaldococcus jannaschii under shifting extremes of temperature and pressure. Extremophiles : Life Under Extreme Conditions. 11: 495-503. PMID 17332989 DOI: 10.1007/s00792-007-0063-4  1
2007 Akbar U, Aschenbrenner CD, Harper MR, Johnson HR, Dordick JS, Clark DS. Direct solubilization of enzyme aggregates with enhanced activity in nonaqueous media. Biotechnology and Bioengineering. 96: 1030-9. PMID 17171716 DOI: 10.1002/Bit.21291  1
2007 Johnson HR, Hooker JM, Francis MB, Clark DS. Solubilization and stabilization of bacteriophage MS2 in organic solvents Biotechnology and Bioengineering. 97: 224-234. PMID 17099911 DOI: 10.1002/Bit.21245  1
2006 Boonyaratanakornkit B, Córdova J, Park CB, Clark DS. Pressure affects transcription profiles of Methanocaldococcus jannaschii despite the absence of barophilic growth under gas-transfer limitation. Environmental Microbiology. 8: 2031-5. PMID 17014501 DOI: 10.1111/J.1462-2920.2006.01083.X  1
2006 Forbes NS, Meadows AL, Clark DS, Blanch HW. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metabolic Engineering. 8: 639-52. PMID 16904360 DOI: 10.1016/J.Ymben.2006.06.005  1
2006 Eppler RK, Komor RS, Huynh J, Dordick JS, Reimer JA, Clark DS. Water dynamics and salt-activation of enzymes in organic media: mechanistic implications revealed by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 103: 5706-10. PMID 16585507 DOI: 10.1073/Pnas.0601113103  1
2006 Kumar RA, Clark DS. High-throughput screening of biocatalytic activity: applications in drug discovery. Current Opinion in Chemical Biology. 10: 162-8. PMID 16520085 DOI: 10.1016/J.Cbpa.2006.02.033  1
2006 Park JB, Clark DS. Deactivation mechanisms of chloroperoxidase during biotransformations. Biotechnology and Bioengineering. 93: 1190-5. PMID 16425305 DOI: 10.1002/Bit.20825  1
2006 Park JB, Clark DS. New reaction system for hydrocarbon oxidation by chloroperoxidase. Biotechnology and Bioengineering. 94: 189-92. PMID 16276530 DOI: 10.1002/Bit.20769  1
2006 Robb FT, Shukla HD, Clark DS. 10 Heat Shock Proteins in Hyperthermophiles Methods in Microbiology. 35: 233-252. DOI: 10.1016/S0580-9517(08)70013-8  1
2006 Park CB, Boonyaratanakornkit BB, Clark DS. 5 Toward the Large Scale Cultivation of Hyperthermophiles at High-Temperature and High-Pressure Methods in Microbiology. 35: 109-126. DOI: 10.1016/S0580-9517(08)70008-4  1
2006 Lee MY, Clark DS, Dordick JS. Human P450 Microarrays for In Vitro Toxicity Analysis: Toward Complete Automation of Human Toxicology Screening Jala - Journal of the Association For Laboratory Automation. 11: 374-380. DOI: 10.1016/J.Jala.2006.08.003  1
2005 Hudson EP, Eppler RK, Clark DS. Biocatalysis in semi-aqueous and nearly anhydrous conditions. Current Opinion in Biotechnology. 16: 637-43. PMID 16256329 DOI: 10.1016/J.Copbio.2005.10.004  1
2005 Boonyaratanakornkit BB, Simpson AJ, Whitehead TA, Fraser CM, El-Sayed NM, Clark DS. Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non-lethal cold shock. Environmental Microbiology. 7: 789-97. PMID 15892698 DOI: 10.1111/J.1462-2920.2005.00751.X  1
2005 Lee MY, Park CB, Dordick JS, Clark DS. Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. Proceedings of the National Academy of Sciences of the United States of America. 102: 983-7. PMID 15657119 DOI: 10.1073/Pnas.0406755102  1
2004 Renninger N, Knopp R, Nitsche H, Clark DS, Keasling JD. Uranyl precipitation by Pseudomonas aeruginosa via controlled polyphosphate metabolism Applied and Environmental Microbiology. 70: 7404-7412. PMID 15574942 DOI: 10.1128/Aem.70.12.7404-7412.2004  1
2004 Gerber R, Ryan JD, Clark DS. Cell-based screen of HMG-CoA reductase inhibitors and expression regulators using LC-MS. Analytical Biochemistry. 329: 28-34. PMID 15136164 DOI: 10.1016/J.Ab.2004.03.023  1
2004 Lindsay JP, Clark DS, Dordick JS. Combinatorial formulation of biocatalyst preparations for increased activity in organic solvents: salt activation of penicillin amidase. Biotechnology and Bioengineering. 85: 553-60. PMID 14760696 DOI: 10.1002/Bit.20002  1
2003 Altreuter DH, Dordick JS, Clark DS. Solid-phase peptide synthesis by ion-paired alpha-chymotrypsin in nonaqueous media. Biotechnology and Bioengineering. 81: 809-17. PMID 12557314 DOI: 10.1002/Bit.10536  1
2002 Clark DS, Bailey JE. Structure-function relationships in immobilized chymotrypsin catalysis. Biotechnology and Bioengineering. 79: 539-49. PMID 12209825 DOI: 10.1002/bit.10438  1
2002 Rich JO, Mozhaev VV, Dordick JS, Clark DS, Khmelnitsky YL. Molecular imprinting of enzymes with water-insoluble ligands for nonaqueous biocatalysis. Journal of the American Chemical Society. 124: 5254-5. PMID 11996551 DOI: 10.1021/Ja012219Z  1
2002 Boonyaratanakornkit BB, Park CB, Clark DS. Pressure effects on intra- and intermolecular interactions within proteins. Biochimica Et Biophysica Acta. 1595: 235-49. PMID 11983399 DOI: 10.1016/S0167-4838(01)00347-8  1
2002 Park CB, Clark DS. Rupture of the cell envelope by decompression of the deep-sea methanogen Methanococcus jannaschii. Applied and Environmental Microbiology. 68: 1458-63. PMID 11872502 DOI: 10.1128/Aem.68.3.1458-1463.2002  1
2002 Park CB, Clark DS. Sol-gel encapsulated enzyme arrays for high-throughput screening of biocatalytic activity. Biotechnology and Bioengineering. 78: 229-35. PMID 11870613 DOI: 10.1002/Bit.10238  1
2002 Altreuter DH, Dordick JS, Clark DS. Nonaqueous biocatalytic synthesis of new cytotoxic doxorubicin derivatives: exploiting unexpected differences in the regioselectivity of salt-activated and solubilized subtilisin. Journal of the American Chemical Society. 124: 1871-6. PMID 11866597 DOI: 10.1021/Ja015977Y  1
2002 Lindsay JP, Clark DS, Dordick JS. Penicillin amidase is activated for use in nonaqueous media by lyophilizing in the presence of potassium chloride Enzyme and Microbial Technology. 31: 193-197. DOI: 10.1016/S0141-0229(02)00132-1  1
2002 Altreuter DH, Dordick JS, Clark DS. Optimization of ion-paired lipase for non-aqueous media: Acylation of doxorubicin based on surface models of fatty acid esterification Enzyme and Microbial Technology. 31: 10-19. DOI: 10.1016/S0141-0229(02)00092-3  1
2001 Renninger N, McMahon KD, Knopp R, Nitsche H, Clark DS, Keasling JD. Uranyl precipitation by biomass from an enhanced biological phosphorus removal reactor. Biodegradation. 12: 401-10. PMID 12051646 DOI: 10.1023/A:1015018104682  1
2001 Ru MT, Wu KC, Lindsay JP, Dordick JS, Reimer JA, Clark DS. Towards more active biocatalysts in organic media: increasing the activity of salt-activated enzymes. Biotechnology and Bioengineering. 75: 187-96. PMID 11536141 DOI: 10.1002/Bit.1178  1
2001 Sun MM, Caillot R, Mak G, Robb FT, Clark DS. Mechanism of pressure-induced thermostabilization of proteins: studies of glutamate dehydrogenases from the hyperthermophile Thermococcus litoralis. Protein Science : a Publication of the Protein Society. 10: 1750-7. PMID 11514665 DOI: 10.1110/Ps.4001  1
2001 Forbes NS, Clark DS, Blanch HW. Using isotopomer path tracing to quantify metabolic fluxes in pathway models containing reversible reactions. Biotechnology and Bioengineering. 74: 196-211. PMID 11400093 DOI: 10.1002/Bit.1109  1
2001 Sun MM, Clark DS. Pressure effects on activity and stability of hyperthermophilic enzymes. Methods in Enzymology. 334: 316-27. PMID 11398475 DOI: 10.1016/S0076-6879(01)34479-8  0.84
2001 Beadell JS, Clark DS. Probing stability-activity relationships in the thermophilic proteasome from Thermoplasma acidophilum by random mutagenesis. Extremophiles : Life Under Extreme Conditions. 5: 3-10. PMID 11302500 DOI: 10.1007/S007920000171  1
2001 Kim YD, Dordick JS, Clark DS. Siloxane-based biocatalytic films and paints for use as reactive coatings Biotechnology and Bioengineering. 72: 475-482. PMID 11180067 DOI: 10.1002/1097-0290(20010220)72:4<475::Aid-Bit1009>3.0.Co;2-F  1
2000 Bang SW, Clark DS, Keasling JD. Engineering hydrogen sulfide production and cadmium removal by expression of the thiosulfate reductase gene (phsABC) from Salmonella enterica serovar typhimurium in Escherichia coli Applied and Environmental Microbiology. 66: 3939-3944. PMID 10966412 DOI: 10.1128/Aem.66.9.3939-3944.2000  1
2000 Liu XC, Clark DS, Dordick JS. Chemoenzymatic construction of a four-component Ugi combinatorial library Biotechnology and Bioengineering. 69: 457-460. PMID 10862684 DOI: 10.1002/1097-0290(20000820)69:4<457::Aid-Bit12>3.0.Co;2-L  1
2000 Kim J, Clark DS, Dordick JS. Intrinsic effects of solvent polarity on enzymic activation energies Biotechnology and Bioengineering. 67: 112-116. PMID 10581442 DOI: 10.1002/(Sici)1097-0290(20000105)67:1<112::Aid-Bit13>3.0.Co;2-E  1
2000 Bang SW, Clark DS, Keasling JD. Cadmium, lead, and zinc removal by expression of the thiosulfate reductase gene from Salmonella typhimurium in Escherichia coli Biotechnology Letters. 22: 1331-1335. DOI: 10.1023/A:1005611331948  1
2000 Ru MT, Hirokane SY, Lo AS, Dordick JS, Reimer JA, Clark DS. On the salt-induced activation of lyophilized enzymes in organic solvents: Effect of salt kosmotropicity on enzyme activity Journal of the American Chemical Society. 122: 1565-1571. DOI: 10.1021/Ja9935198  1
1999 Sun MM, Tolliday N, Vetriani C, Robb FT, Clark DS. Pressure-induced thermostabilization of glutamate dehydrogenase from the hyperthermophile Pyrococcus furiosus. Protein Science : a Publication of the Protein Society. 8: 1056-63. PMID 10338016 DOI: 10.1110/Ps.8.5.1056  1
1999 Altreuter DH, Clark DS. Combinatorial biocatalysis: taking the lead from nature. Current Opinion in Biotechnology. 10: 130-6. PMID 10209140 DOI: 10.1016/S0958-1669(99)80022-6  1
1999 Ru MT, Dordick JS, Reimer JA, Clark DS. Optimizing the salt-induced activation of enzymes in organic solvents: effects of lyophilization time and water content. Biotechnology and Bioengineering. 63: 233-41. PMID 10099600 DOI: 10.1002/(Sici)1097-0290(19990420)63:2<233::Aid-Bit12>3.0.Co;2-S  1
1999 Kraus JJ, Munir IZ, McEldoon JP, Clark DS, Dordick JS. Oxidation of polycyclic aromatic hydrocarbons catalyzed by soybean peroxidase Applied Biochemistry and Biotechnology - Part a Enzyme Engineering and Biotechnology. 80: 221-230. DOI: 10.1385/Abab:80:3:221  1
1998 Bedell BA, Mozhaev VV, Clark DS, Dordick JS. Testing for diffusion limitations in salt-activated enzyme catalysts operating in organic solvents Biotechnology and Bioengineering. 58: 654-657. PMID 10099304 DOI: 10.1002/(Sici)1097-0290(19980620)58:6<654::Aid-Bit12>3.0.Co;2-7  1
1998 Lee CS, Ru MT, Haake M, Dordick JS, Reimer JA, Clark DS. Multinuclear NMR study of enzyme hydration in an organic solvent. Biotechnology and Bioengineering. 57: 686-93. PMID 10099248 DOI: 10.1002/(Sici)1097-0290(19980320)57:6<686::Aid-Bit6>3.0.Co;2-H  1
1998 Mancuso A, Sharfstein ST, Fernandez EJ, Clark DS, Blanch HW. Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: an in vivo 13C nuclear magnetic resonance study. Biotechnology and Bioengineering. 57: 172-86. PMID 10099192 DOI: 10.1002/(Sici)1097-0290(19980120)57:2<172::Aid-Bit6>3.0.Co;2-K  1
1998 Kowalski JM, Kelly RM, Konisky J, Clark DS, Wittrup KD. Purification and functional characterization of a chaperone from Methanococcus jannaschii Systematic and Applied Microbiology. 21: 173-178. PMID 9704106 DOI: 10.1016/S0723-2020(98)80021-0  1
1998 Michels PC, Khmelnitsky YL, Dordick JS, Clark DS. Combinatorial biocatalysis: A natural approach to drug discovery Trends in Biotechnology. 16: 210-215. PMID 9621460 DOI: 10.1016/S0167-7799(98)01190-1  1
1997 Wang CL, Michels PC, Dawson SC, Kitisakkul S, Baross JA, Keasling JD, Clark DS. Cadmium removal by a new strain of Pseudomonas aeruginosa in aerobic culture. Applied and Environmental Microbiology. 63: 4075-8. PMID 9327571 DOI: 10.1128/Aem.63.10.4075-4078.1997  1
1997 Michels PC, Dordick JS, Clark DS. Dipole formation and solvent electrostriction in subtilisin catalysis Journal of the American Chemical Society. 119: 9331-9335. DOI: 10.1021/Ja9713892  1
1997 Wangikar PP, Michels PC, Clark DS, Dordick JS. Structure and function of subtilisin BPN' solubilized in organic solvents Journal of the American Chemical Society. 119: 70-76. DOI: 10.1021/Ja962620Z  1
1996 Wangikar PP, Carmichael D, Clark DS, Dordick JS. Active-site titration of serine proteases in organic solvents. Biotechnology and Bioengineering. 50: 329-35. PMID 18626960 DOI: 10.1002/(Sici)1097-0290(19960505)50:3<329::Aid-Bit11>3.0.Co;2-I  1
1996 Clark DS, Sun MM, Giarto L, Michels PC, Matschiner A, Robb FT. Stabilization of Thermophilic Enzymes by Pressure Progress in Biotechnology. 13: 195-202. DOI: 10.1016/S0921-0423(06)80035-3  1
1995 Fernandez MM, Margot AO, Falender CA, Blanch HW, Clark DS. Enzymatic synthesis of peptides containing unnatural amino acids. Enzyme and Microbial Technology. 17: 964-71. PMID 8541021 DOI: 10.1016/0141-0229(94)00119-7  1
1995 Guinn RM, Margot AO, Taylor JR, Schumacher M, Clark DS, Blanch HW. Synthesis and characterization of polyamides containing unnatural amino acids. Biopolymers. 35: 503-12. PMID 7766820 DOI: 10.1002/Bip.360350509  1
1995 Falender CA, Blanch HW, Clark DS. Enzymatic oligomerization of the tetrapeptide ester allylglycine-phenylalanine-phenylalanine-allylglycine ethyl ester Biocatalysis and Biotransformation. 13: 131-139. DOI: 10.3109/10242429509015218  1
1994 Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnology and Bioengineering. 44: 563-85. PMID 18618793 DOI: 10.1002/Bit.260440504  1
1994 Hiller GW, Clark DS, Blanch HW. Transient responses of hybridoma cells in continuous culture to step changes in amino acid and vitamin concentrations. Biotechnology and Bioengineering. 44: 303-21. PMID 18618747 DOI: 10.1002/Bit.260440308  1
1994 Sharfstein ST, Tucker SN, Mancuso A, Blanch HW, Clark DS. Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism. Biotechnology and Bioengineering. 43: 1059-74. PMID 18615517 DOI: 10.1002/Bit.260431109  1
1993 Hiller GW, Clark DS, Blanch HW. Cell retention-chemostat studies of hybridoma cells-analysis of hybridoma growth and metabolism in continuous suspension culture in serum-free medium. Biotechnology and Bioengineering. 42: 185-95. PMID 18612979 DOI: 10.1002/Bit.260420206  1
1993 Sears PS, Clark DS. Comparison of soluble and immobilized trypsin kinetics: Implications for peptide synthesis. Biotechnology and Bioengineering. 42: 118-24. PMID 18609655 DOI: 10.1002/Bit.260420116  1
1993 Spitznagel TM, Jacobs JW, Clark DS. Random and site-specific immobilization of catalytic antibodies Enzyme and Microbial Technology. 15: 916-921. PMID 7764251 DOI: 10.1016/0141-0229(93)90166-Y  1
1993 Skerker PS, Jacobs JW, Clark DS, Schultz PG. Probing a catalytic antibody active site using spin-labelled haptens Bioorganic and Medicinal Chemistry Letters. 3: 285-288. DOI: 10.1016/S0960-894X(01)80894-5  1
1992 Sharfstein ST, Gaillard B, Blanch HW, Clark DS. Functional differentiation and primary metabolism of mouse mammary epithelial cells in extended-batch and hollow-fiber culture. Biotechnology and Bioengineering. 40: 672-80. PMID 18601166 DOI: 10.1002/Bit.260400605  1
1991 Hiller GW, Aeschlimann AD, Clark DS, Blanch HW. A kinetic analysis of hybridoma growth and metabolism in continuous suspension culture on serum-free medium. Biotechnology and Bioengineering. 38: 733-41. PMID 18600799 DOI: 10.1002/Bit.260380707  1
1991 Fernandez MM, Clark DS, Blanch HW. Papain kinetics in the presence of a water-miscible organic solvent. Biotechnology and Bioengineering. 37: 967-72. PMID 18597322 DOI: 10.1002/Bit.260371011  1
1991 Michiels AG, Wang AY, Clark DS, Blanch HW. Inhibition of dextransucrase by alpha-D-glucose derivatives. Applied Biochemistry and Biotechnology. 31: 237-46. PMID 1840171 DOI: 10.1007/Bf02921750  1
1991 Miller DA, Clark DS, Blanch HW, Prausnitz JM. Fatty acid aggregation in supercritical carbon dioxide The Journal of Supercritical Fluids. 4: 124-126. DOI: 10.1016/0896-8446(91)90040-D  1
1991 Guinn RM, Blanch HW, Clark DS. Effect of a water-miscible organic solvent on the kinetic and structural properties of trypsin Enzyme and Microbial Technology. 13: 320-326. DOI: 10.1016/0141-0229(91)90151-Y  1
1990 Fernandez EJ, Mancuso A, Murphy MK, Blanch HW, Clark DS. Nuclear magnetic resonance methods for observing the intracellular environment of mammalian cells. Annals of the New York Academy of Sciences. 589: 458-75. PMID 2357030 DOI: 10.1111/J.1749-6632.1990.Tb24264.X  1
1990 Mancuso A, Fernandez EJ, Blanch HW, Clark DS. A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors. Bio/Technology (Nature Publishing Company). 8: 1282-5. PMID 1366962 DOI: 10.1038/Nbt0210-178E  1
1989 Murphy MK, Fernandez EJ, Clark DS. A comparison of three radiofrequency coils for NMR studies of conductive samples Magnetic Resonance in Medicine. 12: 382-389. PMID 2628686 DOI: 10.1002/Mrm.1910120311  1
1988 Randolph TW, Clark DS, Blanch HW, Prausnitz JM. Enzymatic oxidation of cholesterol aggregates in supercritical carbon dioxide. Science (New York, N.Y.). 239: 387-90. PMID 17836870 DOI: 10.1126/Science.239.4838.387  1
1988 Clark DS, Skerker PS, Randolph TW, Blanch HW, Prausnitz JM. Conformational analyses of enzymes and substrates in processing environments. Annals of the New York Academy of Sciences. 542: 16-29. PMID 2852476 DOI: 10.1111/J.1749-6632.1988.Tb25804.X  1
1988 Randolph TW, Clark DS, Blanch HW, Prausnitz JM. Cholesterol aggregation and interaction with cholesterol oxidase in supercritical carbon dioxide. Proceedings of the National Academy of Sciences of the United States of America. 85: 2979-83. PMID 2834725 DOI: 10.1073/Pnas.85.9.2979  1
1988 Miller JF, Almond EL, Shah NN, Ludlow JM, Zollweg JA, Streett WB, Zinder SH, Clark DS. High‐pressure—temperature bioreactor for studying pressure—temperature relationships in bacterial growth and productivity Biotechnology and Bioengineering. 31: 407-413. DOI: 10.1002/Bit.260310503  1
1987 Bailey JE, Clark DS. Electron paramagnetic resonance studies of immobilized chymotrypsin. Methods in Enzymology. 135: 502-512. PMID 3600306 DOI: 10.1016/0076-6879(87)35106-7  1
1987 Skerker PS, Miller RR, Millhauser GL, Clark DS. Structural and functional responses of enzymes to immobilization: new insights from EPR spectroscopy. Annals of the New York Academy of Sciences. 501: 80-4. PMID 3037981 DOI: 10.1111/j.1749-6632.1987.tb45688.x  1
1987 Clark DS, Skerker PS, Fernandez EJ, Jagoda RB. SPECTROSCOPIC STUDIES OF STRUCTURE-FUNCTION RELATIONSHIPS IN FREE AND IMMOBILIZED ALCOHOL DEHYDROGENASE Annals of the New York Academy of Sciences. 506: 117-128. PMID 2829683  1
1987 Fernandez EJ, Clark DS. N.m.r. spectroscopy: A non-invasive tool for studying intracellular processes Enzyme and Microbial Technology. 9: 259-271. DOI: 10.1016/0141-0229(87)90001-9  1
1986 Marg GA, Millhauser GL, Skerker PS, Clark DS. Application of EPR methods in studies of immobilized enzyme systems. Annals of the New York Academy of Sciences. 469: 253-8. PMID 3014977 DOI: 10.1111/J.1749-6632.1986.Tb26502.X  1
1985 Clark DS, Bailey JE, Do DD. A mathematical model for restricted diffusion effects on macromolecule impregnation in porous supports. Biotechnology and Bioengineering. 27: 208-13. PMID 18553658 DOI: 10.1002/Bit.260270217  1
1984 Clark DS, Bailey JE. Deactivation kinetics of immobilized alpha-chymotrypsin subpopulations. Biotechnology and Bioengineering. 26: 1090-7. PMID 18553531 DOI: 10.1002/Bit.260260912  1
1984 Dennis KE, Clark DS, Bailey JE, Cho YK, Park YH. Immobilization of enzymes in porous supports: Effects of support-enzyme solution contacting. Biotechnology and Bioengineering. 26: 892-900. PMID 18553474 DOI: 10.1002/Bit.260260812  1
1984 Clark DS, Bailey JE. Characterization of heterogeneous immobilized enzyme subpopulations using EPR spectroscopy. Biotechnology and Bioengineering. 26: 231-8. PMID 18551731 DOI: 10.1002/Bit.260260306  1
1984 Clark DS, Bailey JE. Deactivation of alpha-chymotrypsin and alpha-chymotrypsin-CNBr-Sepharose 4B conjugates in aliphatic alcohols. Biochimica Et Biophysica Acta. 788: 181-8. PMID 6743665 DOI: 10.1016/0167-4838(84)90260-7  1
1984 Clark DS, Bailey JE. Kinetic and EPR spectroscopy studies of immobilized chymotrypsin deactivation. Annals of the New York Academy of Sciences. 434: 31-8. PMID 6098211 DOI: 10.1111/J.1749-6632.1984.Tb29796.X  1
1983 Clark DS, Bailey JE. Structure-function relationships in immobilized chymotrypsin catalysis. Biotechnology and Bioengineering. 25: 1027-47. PMID 18548717 DOI: 10.1002/Bit.260250412  1
1982 Do DD, Clark DS, Bailey JE. Modeling enzyme immobilization in porous solid supports. Biotechnology and Bioengineering. 24: 1527-46. PMID 18546454 DOI: 10.1002/Bit.260240707  1
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