Akihiko Nunomura, MD PhD - Publications

Affiliations: 
Neuropsychiatry Yamanashi University, Kōfu-shi, Yamanashi-ken, Japan 
Area:
Neuropathology, Apoptosis/Cell cycle, Molecular and Cell biology, Oxidative Stress
Website:
http://ns.alzforum.org/com/res/detail.asp?id={3518C0F2-44F7-469F-BD13-D1CC6753571C}

146 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nunomura A, Perry G. RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs. Oxidative Medicine and Cellular Longevity. 2020: 2638130. PMID 33312335 DOI: 10.1155/2020/2638130  0.478
2019 Hata K, Nakamoto K, Nunomura A, Sone D, Maikusa N, Ogawa M, Sato N, Matsuda H. Automated Volumetry of Medial Temporal Lobe Subregions in Mild Cognitive Impairment and Alzheimer Disease. Alzheimer Disease and Associated Disorders. PMID 31135455 DOI: 10.1097/WAD.0000000000000318  0.493
2017 Nunomura A, Lee HG, Zhu X, Perry G. Consequences of RNA oxidation on protein synthesis rate and fidelity: implications for the pathophysiology of neuropsychiatric disorders. Biochemical Society Transactions. PMID 28778984 DOI: 10.1042/BST20160433  0.749
2017 Shimada H, Shoji M, Ikeuchi T, Suzuki K, Senda M, Ishii K, Matsuda H, Iwata A, Ihara R, Iwatsubo T, Mutoh K, Nakazawa E, Sekijima Y, Mori E, Ikeda M, ... ... Nunomura A, et al. [DIAN/DIAN-J/DIAN-TU]. Brain and Nerve = Shinkei Kenkyu No Shinpo. 69: 701-709. PMID 28739983 DOI: 10.11477/Mf.1416200811  0.358
2017 Yamazaki C, Tamaoki T, Nunomura A, Tamai K, Yasuda K, Motohashi N. Plasma Amyloid-β and Alzheimer's Disease-Related Changes in Late-Life Depression. Journal of Alzheimer's Disease : Jad. PMID 28453490 DOI: 10.3233/JAD-170111  0.383
2016 Nunomura A, Zhu X, Perry G. Modulation of Parkinson's Disease Associated Protein Rescues Alzheimer's Disease Degeneration. Journal of Alzheimer's Disease : Jad. PMID 27802241 DOI: 10.3233/JAD-160878  0.74
2016 Nunomura A. Idiopathic basal ganglia calcification (Fahr's disease) and dementia. Psychiatry and Clinical Neurosciences. 70: 129-30. PMID 26939914 DOI: 10.1111/pcn.12378  0.472
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  0.835
2013 Nunomura A. [Oxidative stress hypothesis for Alzheimer's disease and its potential therapeutic implications]. Rinshå Shinkeigaku = Clinical Neurology. 53: 1043-5. PMID 24291874 DOI: DN/JST.JSTAGE/clinicalneurol/53.1043  0.513
2013 Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Research. 47: 507-10. PMID 23566300 DOI: 10.3109/10715762.2013.794265  0.812
2013 Nunomura A. [Role of oxidative RNA damage in aging and neurodegenerative disorders]. Brain and Nerve = Shinkei Kenkyå« No Shinpo. 65: 179-94. PMID 23399675  0.332
2013 Santos RX, Correia SC, Zhu X, Smith MA, Moreira PI, Castellani RJ, Nunomura A, Perry G. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxidants & Redox Signaling. 18: 2444-57. PMID 23216311 DOI: 10.1089/Ars.2012.5039  0.841
2012 Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotoxicity Research. 22: 231-48. PMID 22669748 DOI: 10.1007/s12640-012-9331-x  0.826
2012 Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 39: 4. PMID 22384486 DOI: 10.1017/S0317167100012609  0.849
2012 Nunomura A, Tamaoki T, Motohashi N, Nakamura M, McKeel DW, Tabaton M, Lee HG, Smith MA, Perry G, Zhu X. The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. Journal of Neuropathology and Experimental Neurology. 71: 233-41. PMID 22318126 DOI: 10.1097/NEN.0b013e318248e614  0.837
2012 Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI. Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free Radical Research. 46: 565-76. PMID 22149654 DOI: 10.3109/10715762.2011.648188  0.848
2011 Bonda DJ, Castellani RJ, Zhu X, Nunomura A, Lee HG, Perry G, Smith MA. A novel perspective on tau in Alzheimer's disease. Current Alzheimer Research. 8: 639-42. PMID 21605042 DOI: 10.2174/156720511796717131  0.849
2011 Zhu X, Castellani RJ, Lee H, Petersen RB, Nunomura A, Tabaton M, Perry G. The concept of redox balance in Alzheimer's disease: Mark Anthony Smith 1965–2010 Redox Report. 16: 47-48. DOI: 10.1179/174329211X13020951739893  0.851
2011 Castellani RJ, Zhu X, Nunomura A, Perry G. In Memoriam: Mark A. Smith, PhD: Neuroscientist and Visionary Neuropathology. 31: 458-459. DOI: 10.1111/j.1440-1789.2011.01240.x  0.558
2011 Collins GH, Mondragón-Rodríguez S, Nunomura A, Zhu X, Moreira PI, Smith MA. Oxidative Stress and Balance in Neurodegenerative Diseases Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders: Second Edition. 10-12. DOI: 10.1002/9781444341256.ch3  0.86
2010 Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Casadesus G, Smith MA, Lee HG, Perry G. Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease. International Journal of Biomedical Science : Ijbs. 6: 225-227. PMID 21765811  0.864
2010 Lee HP, Zhu X, Casadesus G, Castellani RJ, Nunomura A, Smith MA, Lee HG, Perry G. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics. 10: 1201-8. PMID 20586698 DOI: 10.1586/ern.10.74  0.856
2010 Bonda DJ, Wang X, Perry G, Nunomura A, Tabaton M, Zhu X, Smith MA. Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology. 59: 290-4. PMID 20394761 DOI: 10.1016/J.Neuropharm.2010.04.005  0.878
2010 Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Akutsu H, Hayashi T. Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid. Free Radical Research. 44: 734-41. PMID 20370566 DOI: 10.3109/10715761003745954  0.676
2010 Smith MA, Zhu X, Tabaton M, Liu G, McKeel DW, Cohen ML, Wang X, Siedlak SL, Dwyer BE, Hayashi T, Nakamura M, Nunomura A, Perry G. Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. Journal of Alzheimer's Disease : Jad. 19: 363-72. PMID 20061651 DOI: 10.3233/Jad-2010-1239  0.829
2010 Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H, Shimohama S, Lee HG, Zhu X, Smith MA, Perry G. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiology of Disease. 37: 731-7. PMID 20034567 DOI: 10.1016/J.Nbd.2009.12.012  0.85
2010 Moreira PI, Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods in Molecular Biology (Clifton, N.J.). 610: 419-34. PMID 20013193 DOI: 10.1007/978-1-60327-029-8_25  0.824
2010 Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA. Mitochondria: a therapeutic target in neurodegeneration. Biochimica Et Biophysica Acta. 1802: 212-20. PMID 19853657 DOI: 10.1016/J.Bbadis.2009.10.007  0.834
2009 Friedlich AL, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA. Treatment advances in Alzheimer's disease based on the oxidative stress model. F1000 Medicine Reports. 1. PMID 20948726 DOI: 10.3410/M1-54  0.873
2009 Perry G, Moreira PI, Siedlak SL, Nunomura A, Zhu X, Smith MA. Natural oxidant balance in Parkinson disease. Archives of Neurology. 66: 1445. PMID 20008647 DOI: 10.1001/Archneurol.2009.261  0.842
2009 Castellani RJ, Lee HG, Siedlak SL, Nunomura A, Hayashi T, Nakamura M, Zhu X, Perry G, Smith MA. Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta. Journal of Alzheimer's Disease : Jad. 18: 447-52. PMID 19584435 DOI: 10.3233/Jad-2009-1151  0.848
2009 Nunomura A, Hofer T, Moreira PI, Castellani RJ, Smith MA, Perry G. RNA oxidation in Alzheimer disease and related neurodegenerative disorders. Acta Neuropathologica. 118: 151-66. PMID 19271225 DOI: 10.1007/s00401-009-0508-1  0.821
2009 Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American Journal of Pathology. 174: 891-7. PMID 19164506 DOI: 10.2353/Ajpath.2009.080583  0.816
2009 Friedlich AL, Smith MA, Zhu X, Takeda A, Nunomura A, Moreira PI, Perry G. Oxidative Stress in Parkinson`s Disease The Open Pathology Journal. 3: 38-42. DOI: 10.2174/1874375700903010038  0.853
2009 Nunomura A, Takeda A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, Perry G. Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease Current Hypotheses and Research Milestones in Alzheimer's Disease. 103-113. DOI: 10.1007/978-0-387-87995-6_9  0.826
2009 Marlatt MW, Moreira PI, Lee Hg, Casadesus G, Castellani RJ, Takeda A, Nunomura A, Zhu X, Perry G, Smith MA. Therapeutic opportunities in Alzheimer disease: Current concepts Frontiers in Medicinal Chemistry. 4: 767-788.  0.843
2008 Castellani RJ, Nunomura A, Rolston RK, Moreira PI, Takeda A, Perry G, Smith MA. Sublethal RNA oxidation as a mechanism for neurodegenerative disease. International Journal of Molecular Sciences. 9: 789-806. PMID 19325784 DOI: 10.3390/Ijms9050789  0.846
2008 Su B, Wang X, Nunomura A, Moreira PI, Lee HG, Perry G, Smith MA, Zhu X. Oxidative stress signaling in Alzheimer's disease. Current Alzheimer Research. 5: 525-32. PMID 19075578 DOI: 10.2174/156720508786898451  0.867
2008 Aliev G, Obrenovich ME, Reddy VP, Shenk JC, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Antioxidant therapy in Alzheimer's disease: theory and practice. Mini Reviews in Medicinal Chemistry. 8: 1395-406. PMID 18991755 DOI: 10.2174/138955708786369582  0.841
2008 Castellani RJ, Nunomura A, Lee HG, Perry G, Smith MA. Phosphorylated tau: toxic, protective, or none of the above. Journal of Alzheimer's Disease : Jad. 14: 377-83. PMID 18688087 DOI: 10.3233/JAD-2008-14404  0.841
2008 Moreira PI, Santos MS, Oliveira CR, Shenk JC, Nunomura A, Smith MA, Zhu X, Perry G. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. Cns & Neurological Disorders Drug Targets. 7: 3-10. PMID 18289026 DOI: 10.2174/187152708783885156  0.891
2008 Moreira PI, Nunomura A, Nakamura M, Takeda A, Shenk JC, Aliev G, Smith MA, Perry G. Nucleic acid oxidation in Alzheimer disease. Free Radical Biology & Medicine. 44: 1493-505. PMID 18258207 DOI: 10.1016/J.Freeradbiomed.2008.01.002  0.865
2007 Nunomura A, Moreira PI, Lee HG, Zhu X, Castellani RJ, Smith MA, Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. Cns & Neurological Disorders Drug Targets. 6: 411-23. PMID 18220780 DOI: 10.2174/187152707783399201  0.866
2007 Nunomura A, Moreira PI, Takeda A, Smith MA, Perry G. Oxidative RNA damage and neurodegeneration. Current Medicinal Chemistry. 14: 2968-75. PMID 18220733 DOI: 10.2174/092986707782794078  0.819
2007 Imaizumi K, Hara H, Ito Y, Takuma K, Nunomura A. Current studies on neuronal death and neurodegenerative diseases. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 130: 477-82. PMID 18079598 DOI: JST.JSTAGE/fpj/130.477  0.303
2007 Hayashi T, Shishido N, Nakayama K, Nunomura A, Smith MA, Perry G, Nakamura M. Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide. Free Radical Biology & Medicine. 43: 1552-9. PMID 17964426 DOI: 10.1016/j.freeradbiomed.2007.08.013  0.672
2007 Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Hayashi Y, Nakayama K, Hayashi T. Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron. Biochemistry. 46: 12737-43. PMID 17929832 DOI: 10.1021/bi701079z  0.718
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy. 3: 614-5. PMID 17786024 DOI: 10.4161/Auto.4872  0.871
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 66: 525-32. PMID 17549012 DOI: 10.1016/J.Jns.2009.02.162  0.847
2007 Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X. Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 11: 143-52. PMID 17522439 DOI: 10.3233/Jad-2007-11202  0.882
2007 Casadesus G, Moreira PI, Nunomura A, Siedlak SL, Bligh-Glover W, Balraj E, Petot G, Smith MA, Perry G. Indices of metabolic dysfunction and oxidative stress. Neurochemical Research. 32: 717-22. PMID 17342408 DOI: 10.1007/S11064-007-9296-Y  0.864
2007 Zhu X, Smith MA, Honda K, Aliev G, Moreira PI, Nunomura A, Casadesus G, Harris PL, Siedlak SL, Perry G. Vascular oxidative stress in Alzheimer disease. Journal of the Neurological Sciences. 257: 240-6. PMID 17337008 DOI: 10.1016/J.Jns.2007.01.039  0.866
2007 Liu Q, Xie F, Rolston R, Moreira PI, Nunomura A, Zhu X, Smith MA, Perry G. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Reviews in Medicinal Chemistry. 7: 171-80. PMID 17305591 DOI: 10.2174/138955707779802552  0.874
2007 Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA. Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses. The Journal of Pharmacology and Experimental Therapeutics. 321: 823-9. PMID 17229880 DOI: 10.1124/jpet.106.114009  0.841
2007 Perry G, Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Smith MA. Mitochondrial autophagocytosis in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 66: 434. DOI: 10.1097/01.Jnen.0000268871.37441.1B  0.844
2007 Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Erratum: Autophagocytosis of mitochondria is prominent in Alzheimer disease (Journal of Neuropathology and Experimental Neurology (2007) 66, (525-532)) Journal of Neuropathology and Experimental Neurology. 66. DOI: 10.1097/01.Jnen.0000263876.99435.Cb  0.857
2007 Perry G, Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Smith MA. Mitochondrial Autophagocytosis in Alzheimer Disease The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a73-c  0.78
2007 Nunomura A, Perry G, Smith MA. Prospects for antioxidant therapy in mild cognitive impairment and alzheimer's disease Oxidative Stress and Neurodegenerative Disorders. 451-466. DOI: 10.1016/B978-044452809-4/50161-7  0.709
2007 Moreira PI, Nunomura A, Honda K, Aliev G, Casadesus G, Zhu X, Smith MA, Perry G. The key role of oxidative stress in alzheimer's disease Oxidative Stress and Neurodegenerative Disorders. 267-281. DOI: 10.1016/B978-044452809-4/50153-8  0.872
2007 Moreira PI, Smith MA, Zhu X, Nunomura A, Perry G. The potential application of antioxidant agents in Alzheimer disease therapeutics Pharmacological Mechanisms in Alzheimer's Therapeutics. 194-211. DOI: 10.1007/978-0-387-71522-3_12  0.791
2007 Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Alzheimer's disease: Pathology vs etiology International Journal of Neuroprotection and Neuroregeneration. 4: 36-40.  0.674
2007 Lee HG, Nunomura A, Perry G, Smith MA. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 402-403.  0.368
2006 Nunomura A, Honda K, Takeda A, Hirai K, Zhu X, Smith MA, Perry G. Oxidative damage to RNA in neurodegenerative diseases. Journal of Biomedicine & Biotechnology. 2006: 82323. PMID 17047315 DOI: 10.1155/Jbb/2006/82323  0.849
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! The American Journal of Pathology. 169: 738-9. PMID 16936250 DOI: 10.2353/ajpath.2006.060633  0.812
2006 Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA. Involvement of oxidative stress in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 631-41. PMID 16825950 DOI: 10.1097/01.jnen.0000228136.58062.bf  0.876
2006 Lee HG, Perry G, Zhu X, Nunomura A, Smith MA. Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression". Free Radical Biology & Medicine. 41: 188-9. PMID 16814097 DOI: 10.1016/j.freeradbiomed.2006.03.014  0.842
2006 Moreira PI, Zhu X, Nunomura A, Smith MA, Perry G. Therapeutic options in Alzheimer's disease. Expert Review of Neurotherapeutics. 6: 897-910. PMID 16784412 DOI: 10.1586/14737175.6.6.897  0.836
2006 Castellani RJ, Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathologica. 111: 503-9. PMID 16718346 DOI: 10.1007/s00401-006-0071-y  0.871
2006 Nunomura A, Castellani RJ, Lee HG, Moreira PI, Zhu X, Perry G, Smith MA. Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream. Science of Aging Knowledge Environment : Sage Ke. 2006: pe10. PMID 16672726 DOI: 10.1126/sageke.2006.8.pe10  0.87
2006 Lee HG, Zhu X, Nunomura A, Perry G, Smith MA. Amyloid beta: the alternate hypothesis. Current Alzheimer Research. 3: 75-80. PMID 16472207 DOI: 10.2174/156720506775697124  0.854
2006 Moreira PI, Honda K, Zhu X, Nunomura A, Casadesus G, Smith MA, Perry G. Brain and brawn: parallels in oxidative strength. Neurology. 66: S97-101. PMID 16432155 DOI: 10.1212/01.wnl.0000192307.15103.83  0.868
2006 Moreira PI, Zhu X, Lee H, Nunomura A, Smith MA, Perry G. Therapeutic potential of oxidative stress reduction in Alzheimer's disease Future Neurology. 1: 1-4. DOI: 10.2217/14796708.1.1.1  0.811
2006 Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Zhu X, Smith MA, Perry G. O4-02-08: Mitochondrial autophagocytosis in Alzheimer disease Alzheimer's & Dementia. 2: S79-S79. DOI: 10.1016/J.Jalz.2006.05.307  0.824
2006 Nunomura A, Chiba S, Yamaguchi H, Smith MA, Perry G. P3-369: Intraneuronal amyloid-β42 may silence oxidative stress in Alzheimer's disease Alzheimer's & Dementia. 2: S484-S484. DOI: 10.1016/j.jalz.2006.05.1639  0.791
2005 Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Current Alzheimer Research. 2: 403-8. PMID 16248845 DOI: 10.2174/156720505774330537  0.871
2005 Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into the oxidant mechanisms in Alzheimer's disease. Current Neurovascular Research. 2: 179-84. PMID 16181112 DOI: 10.2174/1567202053586758  0.884
2005 Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, et al. Redox metals and oxidative abnormalities in human prion diseases. Acta Neuropathologica. 110: 232-8. PMID 16096758 DOI: 10.1007/S00401-005-1034-4  0.865
2005 Moreira PI, Smith MA, Zhu X, Nunomura A, Castellani RJ, Perry G. Oxidative stress and neurodegeneration. Annals of the New York Academy of Sciences. 1043: 545-52. PMID 16037277 DOI: 10.1196/annals.1333.062  0.872
2005 Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA. Tau phosphorylation in Alzheimer's disease: pathogen or protector? Trends in Molecular Medicine. 11: 164-9. PMID 15823754 DOI: 10.1016/J.Molmed.2005.02.008  0.866
2005 Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, et al. Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. The Journal of Biological Chemistry. 280: 20978-86. PMID 15767256 DOI: 10.1074/Jbc.M500526200  0.818
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005  0.832
2005 Smith MA, Nunomura A, Lee HG, Zhu X, Moreira PI, Avila J, Perry G. Chronological primacy of oxidative stress in Alzheimer disease. Neurobiology of Aging. 26: 579-80. PMID 15708430 DOI: 10.1016/j.neurobiolaging.2004.09.021  0.874
2005 Liu Q, Lee HG, Honda K, Siedlak SL, Harris PL, Cash AD, Zhu X, Avila J, Nunomura A, Takeda A, Smith MA, Perry G. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 211-5. PMID 15615639 DOI: 10.1016/J.Bbadis.2004.06.021  0.873
2004 Liu Q, Xie F, Siedlak SL, Nunomura A, Honda K, Moreira PI, Zhua X, Smith MA, Perry G. Neurofilament proteins in neurodegenerative diseases. Cellular and Molecular Life Sciences : Cmls. 61: 3057-75. PMID 15583867 DOI: 10.1007/S00018-004-4268-8  0.832
2004 Nunomura A, Chiba S, Lippa CF, Cras P, Kalaria RN, Takeda A, Honda K, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease. Neurobiology of Disease. 17: 108-13. PMID 15350971 DOI: 10.1016/J.Nbd.2004.06.003  0.848
2004 Castellani RJ, Honda K, Zhu X, Cash AD, Nunomura A, Perry G, Smith MA. Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease. Ageing Research Reviews. 3: 319-26. PMID 15231239 DOI: 10.1016/j.arr.2004.01.002  0.845
2004 Honda K, Smith MA, Nunomura A, Harris PL, Siedlak SL, Perry G. P4-250 Redox-active iron oxidizes ribosomal RNa in neurons vulnerable to Alzheimer's disease Neurobiology of Aging. 25: S546. DOI: 10.1016/S0197-4580(04)81808-6  0.846
2004 Nunomura A. S4-02-04 Oxidative stress in Alzheimer's disease: the earliest event and an attractive therapeutic target Neurobiology of Aging. 25: S69. DOI: 10.1016/S0197-4580(04)80234-3  0.549
2003 Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA. Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxidants & Redox Signaling. 5: 571-6. PMID 14580312 DOI: 10.1089/152308603770310220  0.871
2003 Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA. A metabolic basis for Alzheimer disease. Neurochemical Research. 28: 1549-52. PMID 14570400 DOI: 10.1023/A:1025678510480  0.836
2003 Tateyama M, Takeda A, Onodera Y, Matsuzaki M, Hasegawa T, Nunomura A, Hirai K, Perry G, Smith MA, Itoyama Y. Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles. Acta Neuropathologica. 105: 581-5. PMID 12734664 DOI: 10.1007/S00401-003-0685-2  0.755
2003 Cash AD, Aliev G, Siedlak SL, Nunomura A, Fujioka H, Zhu X, Raina AK, Vinters HV, Tabaton M, Johnson AB, Paula-Barbosa M, Avíla J, Jones PK, Castellani RJ, Smith MA, et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. The American Journal of Pathology. 162: 1623-7. PMID 12707046 DOI: 10.1016/S0002-9440(10)64296-4  0.831
2003 Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA. Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 16: 77-81. PMID 12572666 DOI: 10.1023/A:1020731021276  0.85
2003 Perry G, Ávila J, Casadesus G, Nunomura A, Tabaton M, Cash A, Aliev G, Wataya T, Shimohama S, Drew K, Atwoo C, Smith M. La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer Revista Chilena De Neuro-PsiquiatríA. 41. DOI: 10.4067/S0717-92272003041200006  0.776
2003 Perry G, Ávila J, Casadesus G, Nunomura A, Tabaton M, Cash A, Aliev G, Wataya T, Shimohama S, Drew K, Atwood C, Smith M. The role of oxidative stress in the pathogenesis of Alzheimer's disease | La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer Revista Chilena De Neuro-Psiquiatria. 41: 47-52.  0.858
2002 Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J, Castellani RJ, Smith MA. Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 133: 507-13. PMID 12458179 DOI: 10.1016/S1532-0456(02)00119-9  0.861
2002 Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA. Reactive oxygen: its sources and significance in Alzheimer disease. Journal of Neural Transmission. Supplementum. 69-75. PMID 12456052 DOI: 10.1007/978-3-7091-6139-5_7  0.851
2002 Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9. PMID 12446204 DOI: 10.1016/S0891-5849(02)01113-9  0.88
2002 Nunomura A, Chiba S, Kosaka K, Takeda A, Castellani RJ, Smith MA, Perry G. Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies. Neuroreport. 13: 2035-9. PMID 12438921 DOI: 10.1097/00001756-200211150-00009  0.829
2002 Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA. Role of mitochondrial dysfunction in Alzheimer's disease. Journal of Neuroscience Research. 70: 357-60. PMID 12391597 DOI: 10.1002/Jnr.10389  0.848
2002 Rottkamp CA, Atwood CS, Joseph JA, Nunomura A, Perry G, Smith MA. The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease. Peptides. 23: 1333-41. PMID 12128090 DOI: 10.1016/S0196-9781(02)00069-4  0.724
2002 Kikuchi A, Takeda A, Onodera H, Kimpara T, Hisanaga K, Sato N, Nunomura A, Castellani RJ, Perry G, Smith MA, Itoyama Y. Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy. Neurobiology of Disease. 9: 244-8. PMID 11895375 DOI: 10.1006/Nbdi.2002.0466  0.805
2002 Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International. 40: 527-31. PMID 11850109 DOI: 10.1016/S0197-0186(01)00123-1  0.848
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  0.775
2002 Aliev G, Smith MA, Seyidov D, Neal ML, Lamb BT, Nunomura A, Gasimov EK, Vinters HV, Perry G, LaManna JC, Friedland RP. The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). 12: 21-35. PMID 11770899 DOI: 10.1111/J.1750-3639.2002.Tb00419.X  0.826
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/Jbc.M110913200  0.805
2001 Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mechanisms of Ageing and Development. 123: 39-46. PMID 11640950 DOI: 10.1016/S0047-6374(01)00342-6  0.819
2001 Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 60: 759-67. PMID 11487050 DOI: 10.1093/Jnen/60.8.759  0.875
2001 Raina AK, Hochman A, Zhu X, Rottkamp CA, Nunomura A, Siedlak SL, Boux H, Castellani RJ, Perry G, Smith MA. Abortive apoptosis in Alzheimer's disease. Acta Neuropathologica. 101: 305-10. PMID 11355301 DOI: 10.1007/S004010100378  0.82
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, et al. Mitochondrial abnormalities in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3017-23. PMID 11312286  0.872
2001 Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, et al. Mitochondrial Abnormalities in Alzheimer's Disease The Journal of Neuroscience. 21: 3017-3023. DOI: 10.1523/Jneurosci.21-09-03017.2001  0.873
2000 Nunomura A, Chiba S. Avoidance of Apoptosis in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 2: 59-60. PMID 12214111 DOI: 10.3233/Jad-2000-2107  0.493
2000 Smith MA, Nunomura A, Zhu X, Takeda A, Perry G. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxidants & Redox Signaling. 2: 413-20. PMID 11229355 DOI: 10.1089/15230860050192198  0.784
2000 Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome. Journal of Neuropathology and Experimental Neurology. 59: 1011-7. PMID 11089579 DOI: 10.1093/Jnen/59.11.1011  0.829
2000 Rottkamp CA, Nunomura A, Hirai K, Sayre LM, Perry G, Smith MA. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mechanisms of Ageing and Development. 116: 169-79. PMID 10996017 DOI: 10.1016/S0047-6374(00)00124-X  0.811
2000 Takeda A, Smith MA, Avilá J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry. 75: 1234-41. PMID 10936206 DOI: 10.1046/J.1471-4159.2000.0751234.X  0.839
2000 Smith MA, Rottkamp CA, Nunomura A, Raina AK, Perry G. Oxidative stress in Alzheimer's disease. Biochimica Et Biophysica Acta. 1502: 139-44. PMID 10899439 DOI: 10.1016/S0925-4439(00)00040-5  0.868
2000 Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S. Activation of NADPH oxidase in Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 273: 5-9. PMID 10873554 DOI: 10.1006/Bbrc.2000.2897  0.764
2000 Rottkamp CA, Nunomura A, Raina AK, Sayre LM, Perry G, Smith MA. Oxidative stress, antioxidants, and Alzheimer disease. Alzheimer Disease and Associated Disorders. 14: S62-6. PMID 10850732 DOI: 10.1097/00002093-200000001-00010  0.849
2000 Raina AK, Perry G, Nunomura A, Sayre LM, Smith MA. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 38: 93-7. PMID 10834395 DOI: 10.1515/Cclm.2000.015  0.772
2000 Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA. Oxidative damage in Alzheimer's disease: the metabolic dimension. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 18: 417-21. PMID 10817925 DOI: 10.1016/S0736-5748(00)00006-X  0.851
2000 Cuajungco MP, Goldstein LE, Nunomura A, Smith MA, Lim JT, Atwood CS, Huang X, Farrag YW, Perry G, Bush AI. Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. The Journal of Biological Chemistry. 275: 19439-42. PMID 10801774 DOI: 10.1074/jbc.C000165200  0.608
2000 Perry G, Raina AK, Nunomura A, Wataya T, Sayre LM, Smith MA. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radical Biology & Medicine. 28: 831-4. PMID 10754280 DOI: 10.1016/S0891-5849(00)00158-1  0.875
2000 Perry G, Nunomura A, Raina AK, Smith MA. Amyloid-beta junkies. Lancet. 355: 757. PMID 10703837 DOI: 10.1016/S0140-6736(05)72173-5  0.726
2000 Perry G, Hirai K, Aliev G, Nunomura A, Siedlak SL, Smith MA. Mitochondrial abnormalities in Alzheimer disease Neurobiology of Aging. 21: 213. DOI: 10.1016/S0197-4580(00)83289-3  0.76
2000 Perry G, Kaminski MA, Nunomura A, Raina AK, Smith MA. What oxidative stress tells us about therapeutic targets for Alzheimer's disease Current Opinion in Central and Peripheral Nervous System Investigational Drugs. 2: 423-426.  0.669
1999 Nunomura A, Perry G, Hirai K, Aliev G, Takeda A, Chiba S, Smith MA. Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome. Annals of the New York Academy of Sciences. 893: 362-4. PMID 10672267 DOI: 10.1111/J.1749-6632.1999.Tb07855.X  0.844
1999 Smith MA, Nunomura A, Takeda A, Perry G. Asking the right questions. Science (New York, N.Y.). 285: 665. PMID 10454920 DOI: 10.1126/Science.285.5428.663E  0.599
1999 Perry G, Roder H, Nunomura A, Takeda A, Friedlich AL, Zhu X, Raina AK, Holbrook N, Siedlak SL, Harris PL, Smith MA. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport. 10: 2411-5. PMID 10439473 DOI: 10.1097/00001756-199908020-00035  0.856
1999 Gerst JL, Siedlak SL, Nunomura A, Castellani R, Perry G, Smith MA. Role of oxidative stress in frontotemporal dementia. Dementia and Geriatric Cognitive Disorders. 10: 85-7. PMID 10436348 DOI: 10.1159/000051220  0.831
1999 Castellani RJ, Smith MA, Nunomura A, Harris PL, Perry G. Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin? Free Radical Biology & Medicine. 26: 1508-12. PMID 10401616 DOI: 10.1016/S0891-5849(99)00016-7  0.796
1999 Raina AK, Takeda A, Nunomura A, Perry G, Smith MA. Genetic evidence for oxidative stress in Alzheimer's disease. Neuroreport. 10: 1355-7. PMID 10363952 DOI: 10.1097/00001756-199904260-00036  0.834
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1959-64. PMID 10066249  0.816
1999 Nunomura A, Perry G, Pappolla MA, Wade R, Hirai K, Chiba S, Smith MA. RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease The Journal of Neuroscience. 19: 1959-1964. DOI: 10.1523/JNEUROSCI.19-06-01959.1999  0.804
1999 Russell RL, Smith MA, Raina AK, Nunomura A, Perry G. ALZHEIMER DISEASE IS MARKED BY A MAJOR SHIFT IN REDOX BALANCE Journal of Neuropathology and Experimental Neurology. 58: 512. DOI: 10.1097/00005072-199905000-00022  0.813
1999 Nunomura A, Perry G, Smith MA. OXIDATION OF NUCLEIC ACIDS IN NEURONS PRECEDES AMYLOID $BT DEPOSITION IN DOWN SYNDROME Journal of Neuropathology and Experimental Neurology. 58: 511. DOI: 10.1097/00005072-199905000-00019  0.607
1999 Aliev G, Smith MA, Vinters H, Johnson AB, Nunomura A, Perry G. MITOCHONDRIA ABNORMALITIES MARK VULNERABLE NEURONS IN ALZHEIMER DISEASE Journal of Neuropathology and Experimental Neurology. 58: 511. DOI: 10.1097/00005072-199905000-00018  0.677
1999 NUNOMURA A, PERRY G, ZHANG J, MONTINE TJ, TAKEDA A, CHIBA S, SMITH MA. RNA Oxidation in Alzheimer and Parkinson Diseases Journal of Anti-Aging Medicine. 2: 227-230. DOI: 10.1089/Rej.1.1999.2.227  0.76
1999 Smith MA, Hirai K, Nunomura A, Perry G. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease Drug Development Research. 46: 26-33. DOI: 10.1002/(SICI)1098-2299(199901)46:1<26::AID-DDR5>3.0.CO;2-8  0.799
1999 Nunomura A, Perry G, Zhang J, Montine TJ, Takeda A, Chiba S, Smith MA. RNA oxidation in Alzheimer and Parkinson diseases Journal of Anti-Aging Medicine. 2: 227-230.  0.458
1999 Smith MA, Hirai K, Nunomura A, Perry G. Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease Drug Development Research. 46: 26-33.  0.646
1998 Perry G, Nunomura A, Lucassen P, Lassmann H, Smith MA. Apoptosis and Alzheimer's disease. Science (New York, N.Y.). 282: 1268-9. PMID 9867630 DOI: 10.1126/Science.282.5392.1265H  0.598
1998 Velasco ME, Smith MA, Siedlak SL, Nunomura A, Perry G. Striation is the characteristic neuritic abnormality in Alzheimer disease. Brain Research. 813: 329-33. PMID 9838181 DOI: 10.1016/S0006-8993(98)01034-8  0.742
1998 Perry G, Nunomura A, Smith MA. A suicide note from Alzheimer disease neurons? Nature Medicine. 4: 897-8. PMID 9701239 DOI: 10.1038/nm0898-897  0.761
1998 Perry G, Wataya T, Nunomura A, Szweda L, Sayre LM, Smith MA. NEUROFILAMENT HEAVY SUBUNIT (NFH) IS A SPECIFIC TARGET OF OXIDATIVE DAMAGE IN THE AXON Journal of Neuropathology and Experimental Neurology. 57: 492. DOI: 10.1097/00005072-199805000-00101  0.743
1996 Nunomura A, Chiba S, Eto M, Saito M, Makino I, Miyagishi T. Apolipoprotein E polymorphism and susceptibility to early- and late-onset sporadic Alzheimer's disease in Hokkaido, the northern part of Japan. Neuroscience Letters. 206: 17-20. PMID 8848271 DOI: 10.1016/0304-3940(96)12415-0  0.388
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