Wayne W. Poon, Ph.D. - Publications

Affiliations: 
2001 University of California, Los Angeles, Los Angeles, CA 
Area:
Biochemistry, Chemical Biology, Proteomics and Bioinformatics, Systems Biology and Biological Regulation, Metabolism, Aging and Development

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Reyes-Ortiz AM, Abud EM, Burns MS, Wu J, Hernandez SJ, McClure N, Wang KQ, Schulz CJ, Miramontes R, Lau A, Michael N, Miyoshi E, Van Vactor D, Reidling JC, Blurton-Jones M, ... ... Poon WW, et al. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. Iscience. 26: 105732. PMID 36590162 DOI: 10.1016/j.isci.2022.105732  0.608
2022 Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, ... ... Poon WW, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 185: 2213-2233.e25. PMID 35750033 DOI: 10.1016/j.cell.2022.05.017  0.508
2022 You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. Journal of Extracellular Vesicles. 11: e12183. PMID 35029059 DOI: 10.1002/jev2.12183  0.662
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Poon W, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.318
2019 Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R, Glabe C, Gylys KH. Apolipoprotein E/Aβ Complex Accumulates in AD Cortical Synapses via apoE Receptors and Is Enhanced by APOE4. The American Journal of Pathology. PMID 31108099 DOI: 10.1016/J.Ajpath.2019.04.010  0.42
2018 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Poon WW, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757  0.457
2018 Rajic AJ, Pressman PS, Poon WW. P1-491: Comparative Analysis Of Clinicopathological Threshold Modeling Using Quantitative Nft Loads, Vascular Disease, And Age-Related Gliosis Against Braak Tangle Stage In Pure Alzheimer Disease Autopsy Cases Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.501  0.32
2017 Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathologica Communications. 5: 93. PMID 29195510 DOI: 10.1186/S40478-017-0499-4  0.572
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Poon WW, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.354
2017 Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, ... ... Poon WW, et al. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 94: 278-293.e9. PMID 28426964 DOI: 10.1016/J.Neuron.2017.03.042  0.682
2017 Gonzalez B, Abud EM, Abud AM, Poon WW, Gylys KH. Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease. Neurologic Clinics. 35: 175-190. PMID 28410655 DOI: 10.1016/J.Ncl.2017.01.001  0.323
2017 Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 8: 235-248. PMID 28199828 DOI: 10.1016/J.Stemcr.2016.12.019  0.666
2016 Chen W, Abud EA, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buée L, Poon WW, Blurton-Jones M. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathologica Communications. 4: 63. PMID 27339073 DOI: 10.1186/S40478-016-0336-1  0.685
2016 Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884167 DOI: 10.1073/Pnas.1525466113  0.751
2016 Zhang L, Trushin S, Christensen TA, Bachmeier BV, Gateno B, Schroeder A, Yao J, Itoh K, Sesaki H, Poon WW, Gylys KH, Patterson ER, Parisi JE, Diaz Brinton R, Salisbury JL, et al. Altered brain energetics induces mitochondrial fission arrest in Alzheimer's Disease. Scientific Reports. 6: 18725. PMID 26729583 DOI: 10.1038/Srep18725  0.358
2016 Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. The American Journal of Pathology. 186: 185-98. PMID 26718979 DOI: 10.1016/J.Ajpath.2015.09.018  0.441
2016 Marsh SE, Karimzadeh A, Abud EM, Lakatos A, Yeung ST, Davtyan H, Fote G, Lau L, Weinger JG, Lane TE, Poon WW, Inlay MA, Blurton-Jones M. P1-158: The Adaptive Immune System Critically Regulates Alzheimer’s Disease Pathogenesis by Modulating Microglial Function Alzheimer's & Dementia. 12: P463-P464. DOI: 10.1016/J.Jalz.2016.06.906  0.707
2015 Day RJ, Mason MJ, Thomas C, Poon WW, Rohn TT. Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain. Plos One. 10: e0132637. PMID 26161867 DOI: 10.1371/Journal.Pone.0132637  0.365
2015 Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, ... ... Poon WW, et al. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. Jama Neurology. 72: 414-22. PMID 25706306 DOI: 10.1001/Jamaneurol.2014.4040  0.509
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Poon WW, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.566
2015 Ager RR, Davis JL, Agazaryan A, Benavente F, Poon WW, LaFerla FM, Blurton-Jones M. Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. 25: 813-26. PMID 25530343 DOI: 10.1002/Hipo.22405  0.692
2015 Sokolow S, Henkins KM, Bilousova T, Gonzalez B, Vinters HV, Miller CA, Cornwell L, Poon WW, Gylys KH. Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease. Journal of Neurochemistry. 133: 368-79. PMID 25393609 DOI: 10.1111/Jnc.12991  0.4
2015 Gylys KH, Bilousova T, Teng E, Vinters HV, Miller CA, Poon WW, Apostolova LG, Frautschy SA, John V, Bredesen DE, Cole GM. O2-06-03: Release of c-terminal truncated and intact tau from Alzheimer's disease cortical synapses Alzheimer's & Dementia. 11: P186-P187. DOI: 10.1016/J.Jalz.2015.07.161  0.334
2014 Bridges LR, Andoh J, Lawrence AJ, Khoong CH, Poon WW, Esiri MM, Markus HS, Hainsworth AH. Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. Journal of Neuropathology and Experimental Neurology. 73: 1026-33. PMID 25289893 DOI: 10.1097/Nen.0000000000000124  0.317
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Poon WW, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.505
2014 Pensalfini A, Albay R, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiology of Disease. 71: 53-61. PMID 25092575 DOI: 10.1016/J.Nbd.2014.07.011  0.418
2014 Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, et al. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathologica. 127: 825-43. PMID 24770881 DOI: 10.1007/S00401-014-1282-2  0.302
2013 Rohn TT, Day RJ, Catlin LW, Brown RJ, Rajic AJ, Poon WW. Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain. Plos One. 8: e80180. PMID 24312462 DOI: 10.1371/Journal.Pone.0080180  0.356
2013 Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW. β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1. The Journal of Biological Chemistry. 288: 16937-48. PMID 23599427 DOI: 10.1074/Jbc.M113.463711  0.729
2013 Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. The Journal of Biological Chemistry. 288: 5914-26. PMID 23293020 DOI: 10.1074/Jbc.M112.442103  0.42
2012 Kim HJ, Park JW, Byun JH, Poon WW, Cotman CW, Fowlkes CC, Jeon NL. Quantitative analysis of axonal transport by using compartmentalized and surface micropatterned culture of neurons. Acs Chemical Neuroscience. 3: 433-8. PMID 24358503 DOI: 10.1021/Cn3000026  0.471
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Poon WW, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.559
2012 Henkins KM, Sokolow S, Miller CA, Vinters HV, Poon WW, Cornwell LB, Saing T, Gylys KH. Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain Pathology (Zurich, Switzerland). 22: 826-33. PMID 22486774 DOI: 10.1111/J.1750-3639.2012.00598.X  0.429
2012 Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathologica. 123: 39-52. PMID 22020632 DOI: 10.1007/S00401-011-0892-1  0.411
2012 Sokolow S, Luu SH, Nandy K, Miller CA, Vinters HV, Poon WW, Gylys KH. Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiology of Disease. 45: 381-7. PMID 21914482 DOI: 10.1016/J.Nbd.2011.08.027  0.412
2012 Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, Cole GM, Gylys KH. AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiology of Aging. 33: 1545-55. PMID 21741125 DOI: 10.1016/J.Neurobiolaging.2011.05.011  0.404
2012 Poon W, Carlos A, Aguilar B, Cotman C. P2-079: Neutrophin-trafficking deficits are mediated by impaired ubiquitin recycling in Alzheimer's disease Alzheimer's & Dementia. 8: P291-P291. DOI: 10.1016/J.Jalz.2012.05.783  0.525
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Poon WW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.557
2011 Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW. β-Amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of Aging. 32: 821-33. PMID 19540623 DOI: 10.1016/J.Neurobiolaging.2009.05.012  0.726
2011 Poon W, Aguilar B, Feinberg L, Seow J, Tu T, Cedeno A, Carlos A, Cotman C. P4-194: Neural stem cells rescue deficits in Alzheimer's transgenic mice Alzheimer's & Dementia. 7: S771-S772. DOI: 10.1016/J.Jalz.2011.05.2217  0.738
2010 Gylys KH, Arold SP, Henkins KM, Poon W, Miller CA, Vinters HV, Cole GM. O4-02-01: Apoliprotein-E is increased in Alzheimer's disease synapses and associates with amyloid beta Alzheimer's & Dementia. 6: S152-S152. DOI: 10.1016/J.Jalz.2010.05.473  0.351
2010 Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Muller F, Loring JF, Poon WW, Green K, LaFerla FM. O1-04-01: Using neural stem cells to promote plasticity and improve cognition in transgenic AD mice Alzheimer's & Dementia. 6: S76-S76. DOI: 10.1016/J.Jalz.2010.05.225  0.657
2010 Poon WW, Carlos AJ, Cotman CW, Rohn TT. P2-212: Overexpression of Bcl-2 in APP transgenic mice reduces amyloid pathology Alzheimer's & Dementia. 6: S376-S376. DOI: 10.1016/J.Jalz.2010.05.1261  0.522
2009 Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 13594-9. PMID 19633196 DOI: 10.1073/Pnas.0901402106  0.688
2008 Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. Journal of Neuroinflammation. 5: 13. PMID 18400101 DOI: 10.1186/1742-2094-5-13  0.761
2005 Marbois B, Gin P, Faull KF, Poon WW, Lee PT, Strahan J, Shepherd JN, Clarke CF. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. The Journal of Biological Chemistry. 280: 20231-8. PMID 15792955 DOI: 10.1074/Jbc.M501315200  0.722
2005 Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. Journal of Neuropathology and Experimental Neurology. 64: 104-12. PMID 15751224 DOI: 10.1093/Jnen/64.2.104  0.708
2005 Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging. 26: 749-63. PMID 15708450 DOI: 10.1016/J.Neurobiolaging.2004.06.015  0.622
2004 Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. Caspase-mediated degeneration in Alzheimer's disease. The American Journal of Pathology. 165: 353-5. PMID 15277211 DOI: 10.1016/S0002-9440(10)63302-0  0.679
2004 Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. The Journal of Clinical Investigation. 114: 121-30. PMID 15232619 DOI: 10.1172/Jci20640  0.719
2000 Poon WW, Davis DE, Ha HT, Jonassen T, Rather PN, Clarke CF. Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. Journal of Bacteriology. 182: 5139-46. PMID 10960098 DOI: 10.1128/Jb.182.18.5139-5146.2000  0.729
1999 Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF. Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. The Journal of Biological Chemistry. 274: 21665-72. PMID 10419476 DOI: 10.1074/Jbc.274.31.21665  0.548
1997 Poon WW, Do TQ, Marbois BN, Clarke CF. Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants. Molecular Aspects of Medicine. 18: S121-7. PMID 9266513 DOI: 10.1016/S0098-2997(97)00004-6  0.732
1996 Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF. Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis. Biochemistry. 35: 9797-806. PMID 8703953 DOI: 10.1021/Bi9602932  0.546
1996 Shepherd JA, Poon WW, Myles DC, Clarke CF. The biosynthesis of ubiquinone: Synthesis and enzymatic modification of biosynthetic precursors Tetrahedron Letters. 37: 2395-2398. DOI: 10.1016/0040-4039(96)00324-3  0.546
1995 Poon WW, Marbois BN, Faull KF, Clarke CF. 3-Hexaprenyl-4-hydroxybenzoic acid forms a predominant intermediate pool in ubiquinone biosynthesis in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 320: 305-14. PMID 7625838 DOI: 10.1016/0003-9861(95)90014-4  0.541
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