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William P. Malachowski - Publications

Affiliations: 
2000- Chemistry Bryn Mawr College, Bryn Mawr, PA, United States 
Area:
synthetic organic chemistry, medicinal chemistry
Website:
http://www.brynmawr.edu/chemistry/malachowski/
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sexton M, Malachowski WP, Yap GPA, Rachii D, Feldman G, Krasley AT, Chen Z, Tran MA, Wiley K, Matei A, Petersen S, Tien ST. Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Phenanthridinone Derivatives with an All-Carbon Quaternary Stereocenter. The Journal of Organic Chemistry. PMID 34985891 DOI: 10.1021/acs.joc.1c02523  0.32
2019 Sexton ME, Okazaki A, Yu Z, van Venrooy A, Schmink JR, Malachowski WP. Palladium-catalyzed mono-γ-arylation of 7-methoxy-4-methylcoumarin Tetrahedron Letters. 60: 151057. DOI: 10.1016/J.Tetlet.2019.151057  0.334
2018 Winters M, DuHadaway JB, Pham KN, Lewis-Ballester A, Badir S, Wai J, Sheikh E, Yeh SR, Prendergast GC, Muller AJ, Malachowski WP. Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase. European Journal of Medicinal Chemistry. 162: 455-464. PMID 30469041 DOI: 10.1016/J.Ejmech.2018.11.010  0.621
2018 Krasley AT, Malachowski WP, Terz HM, Tran Tien S. Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters. Organic Letters. PMID 29561159 DOI: 10.1021/Acs.Orglett.8B00196  0.4
2017 Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ. Discovery of IDO1 Inhibitors: From Bench to Bedside. Cancer Research. 77: 6795-6811. PMID 29247038 DOI: 10.1158/0008-5472.Can-17-2285  0.403
2015 Malachowski WP, Winters M, DuHadaway JB, Lewis-Ballester A, Badir S, Wai J, Rahman M, Sheikh E, LaLonde JM, Yeh SR, Prendergast GC, Muller AJ. O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. European Journal of Medicinal Chemistry. 108: 564-576. PMID 26717206 DOI: 10.1016/J.Ejmech.2015.12.028  0.628
2015 Burke SJ, Malachowski WP, Mehta SK, Appenteng R. The enantioselective construction of tetracyclic diterpene skeletons with Friedel-Crafts alkylation and palladium-catalyzed cycloalkenylation reactions. Organic & Biomolecular Chemistry. 13: 2726-44. PMID 25598198 DOI: 10.1039/C4Ob02489C  0.575
2015 Krasley AT, Malachowski WP. The first report of Lewis acid reagents in the intramolecular Rauhut-Currier reaction Tetrahedron Letters. 56: 6073-6076. DOI: 10.1016/J.Tetlet.2015.09.069  0.327
2014 Ross TM, Burke S, Malachowski WP. Enantioselective synthesis of decalin structures with all-carbon quaternary centers via one-pot sequential Cope/Rauhut-Currier reaction. Tetrahedron Letters. 55: 4616-4618. PMID 25125710 DOI: 10.1016/J.Tetlet.2014.06.085  0.562
2010 Qiao Y, Kumar S, Malachowski WP. Enantioselective synthesis of bicarbocyclic structures with an all-carbon quaternary stereocenter through sequential cross metathesis and intramolecular Rauhut-Currier reaction Tetrahedron Letters. 51: 2636-2638. DOI: 10.1016/J.Tetlet.2010.03.026  0.352
2010 MALACHOWSKI WP, COWARD JK. ChemInform Abstract: The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogues of Glutamyl-. gamma.-glutamate. Cheminform. 26: no-no. DOI: 10.1002/chin.199525214  0.548
2008 Kumar S, Jaller D, Patel B, LaLonde JM, DuHadaway JB, Malachowski WP, Prendergast GC, Muller AJ. Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase Journal of Medicinal Chemistry. 51: 4968-4977. PMID 18665584 DOI: 10.1021/Jm800512Z  0.472
2008 Kumar S, Malachowski WP, DuHadaway JB, LaLonde JM, Carroll PJ, Jaller D, Metz R, Prendergast GC, Muller AJ. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. Journal of Medicinal Chemistry. 51: 1706-18. PMID 18318466 DOI: 10.1021/Jm7014155  0.439
2008 Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 27: 2851-7. PMID 18026137 DOI: 10.1038/Sj.Onc.1210939  0.404
2007 Malachowski WP, Paul T, Phounsavath S. The enantioselective synthesis of (-)-lycoramine with the Birch-Cope sequence. The Journal of Organic Chemistry. 72: 6792-6. PMID 17676911 DOI: 10.1021/Jo070976V  0.391
2007 Paul T, Malachowski WP, Lee J. Exploration of the enantioselective Birch-Cope sequence for the synthesis of carbocyclic quaternary stereocenters. The Journal of Organic Chemistry. 72: 930-7. PMID 17253813 DOI: 10.1021/Jo0621423  0.385
2006 Paul T, Malachowski WP, Lee J. The enantioselective Birch-Cope sequence for the synthesis of carbocyclic quaternary stereocenters. Application to the synthesis of (+)-mesembrine. Organic Letters. 8: 4007-10. PMID 16928060 DOI: 10.1021/Ol0615228  0.384
2006 Gaspari P, Banerjee T, Malachowski WP, Muller AJ, Prendergast GC, DuHadaway J, Bennett S, Donovan AM. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. Journal of Medicinal Chemistry. 49: 684-92. PMID 16420054 DOI: 10.1021/Jm0508888  0.462
2005 Muller AJ, Malachowski WP, Prendergast GC. Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors. Expert Opinion On Therapeutic Targets. 9: 831-49. PMID 16083346 DOI: 10.1517/14728222.9.4.831  0.423
2005 Malachowski WP, Metz R, Prendergast GC, Muller AJ. A new cancer immunosuppression target: Indoleamine 2,3-dioxygenase (IDO). A review of the IDO mechanism, inhibition and therapeutic applications Drugs of the Future. 30: 897-909. DOI: 10.1358/Dof.2005.030.09.918200  0.394
2005 Broadrup RL, Wang B, Malachowski WP. A general strategy for the synthesis of azapeptidomimetic lactams Tetrahedron. 61: 10277-10284. DOI: 10.1016/J.Tet.2005.08.029  0.389
2004 Malachowski WP, Banerji M. Sequential Birch reduction-allylation and Cope rearrangement of o-anisic acid derivatives Tetrahedron Letters. 45: 8183-8185. DOI: 10.1016/J.Tetlet.2004.09.025  0.36
2002 Malachowski WP, Tie C, Wang K, Broadrup RL. The synthesis of azapeptidomimetic beta-lactam molecules as potential protease inhibitors. The Journal of Organic Chemistry. 67: 8962-9. PMID 12467415 DOI: 10.1021/Jo026280D  0.344
1997 Schultz AG, Malachowski WP, Pan Y. Asymmetric total synthesis of (+)-apovincamine and a formal synthesis of (+)-vincamine. Demonstration of a practical 'asymmetric linkage' between aromatic carboxylic acids and chiral acyclic substrates Journal of Organic Chemistry. 62: 1223-1229. DOI: 10.1021/Jo961603P  0.553
1994 Malachowski WP, Coward JK. The Chemistry of Phosphapeptides: Investigations on the Synthesis of Phosphonamidate, Phosphonate, and Phosphinate Analogs of Glutamyl-.gamma.-glutamate Journal of Organic Chemistry. 59: 7625-7634. DOI: 10.1021/Jo00104A017  0.576
1994 Malachowski WP, Coward JK. The chemistry of phosphapeptides: Formation of functionalized phosphonochloridates under mild conditions and their reaction with alcohols and amines Journal of Organic Chemistry. 59: 7616-7624. DOI: 10.1021/Jo00104A016  0.514
1994 Malachowski WP, Coward JK. The chemistry of phosphapeptides: Investigations on the synthesis of phosphonamidate, phosphonate, and phosphinate analogues of glutamyl-γ-glutamate Journal of Organic Chemistry. 59: 7625-7634.  0.552
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