Blair Leavitt - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Estevez-Fraga C, Altmann A, Parker CS, Scahill RI, Costa B, Chen Z, Manzoni C, Zarkali A, Durr A, Roos RAC, Landwehrmeyer B, Leavitt BR, Rees G, Tabrizi SJ, McColgan P. Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration. Brain : a Journal of Neurology. PMID 37587097 DOI: 10.1093/brain/awad275  0.306
2021 Galvan A, Petkau TL, Hill AM, Korecki AJ, Lu G, Choi D, Rahman K, Simpson E, Leavitt BR, Smith Y. Intracerebroventricular Administration of AAV9-PHP.B SYN1-EmGFP Induces Widespread Transgene Expression in the Mouse and Monkey CNS. Human Gene Therapy. PMID 33860682 DOI: 10.1089/hum.2020.301  0.351
2017 Petkau TL, Kosior N, de Asis K, Connolly C, Leavitt BR. Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation. Journal of Neuroinflammation. 14: 225. PMID 29149899 DOI: 10.1186/s12974-017-1000-9  0.362
2017 Petkau TL, Blanco J, Leavitt BR. Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice. Neurobiology of Disease. 106: 14-22. PMID 28647554 DOI: 10.1016/j.nbd.2017.06.012  0.403
2016 Wagner L, Björkqvist M, Hult Lundh S, Wolf R, Börgel A, Schlenzig D, Ludwig HH, Rahfeld JU, Leavitt B, Demuth HU, Petersén Å, von Hörsten S. Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment. Journal of Neurochemistry. PMID 27016395 DOI: 10.1111/Jnc.13624  0.302
2014 Petkau T, Russell-Schulz B, Sturrock A, Hutchinson J, Coleman A, Decolongon J, Hayden, Tabrizi S, Mackay A, Leavitt B. E32 A 36 Month Longitudinal Magnetic Resonance Spectroscopy Study In Pre-manifest And Early Huntington Disease Subjects From The Track-hd Study Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.135  0.316
2014 Gregory S, Scahill R, Durr A, Leavitt B, Roos R, Johnson H, Langbehn, Rees G, Tabrizi S. Structural Connectivity In Huntington'S Disease Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309032.118  0.311
2013 Petkau TL, Zhu S, Lu G, Fernando S, Cynader M, Leavitt BR. Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice. Neurobiology of Aging. 34: 2548-50. PMID 23702345 DOI: 10.1016/J.Neurobiolaging.2013.04.019  0.336
2012 Crawford H, Hobbs N, Cole J, Rees E, Owen G, Langbehn, Frost C, Landwehrmeyer B, Reilmann R, Craufurd D, Stout J, Durr A, Leavitt B, Roos R, Tabrizi S, et al. Corpus Callosal Atrophy In Huntington'S Disease Journal of Neurology, Neurosurgery, and Psychiatry. 83. DOI: 10.1136/Jnnp-2012-303524.83  0.303
2010 Petkau TL, Neal SJ, Orban PC, MacDonald JL, Hill AM, Lu G, Feldman HH, Mackenzie IR, Leavitt BR. Progranulin expression in the developing and adult murine brain. The Journal of Comparative Neurology. 518: 3931-47. PMID 20737593 DOI: 10.1002/cne.22430  0.582
2009 Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2414-27. PMID 19244517 DOI: 10.1523/Jneurosci.5687-08.2009  0.31
2009 Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2193-204. PMID 19228972 DOI: 10.1523/Jneurosci.5473-08.2009  0.334
2007 Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular degeneration in Huntington disease. Neurobiology of Disease. 26: 512-20. PMID 17433700 DOI: 10.1016/J.Nbd.2007.01.006  0.324
2006 Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, ... ... Leavitt BR, et al. Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proceedings of the National Academy of Sciences of the United States of America. 103: 9595-600. PMID 16769894 DOI: 10.1073/Pnas.0510197103  0.323
2006 Leavitt BR, van Raamsdonk JM, Shehadeh J, Fernandes H, Murphy Z, Graham RK, Wellington CL, Raymond LA, Hayden MR. Wild-type huntingtin protects neurons from excitotoxicity. Journal of Neurochemistry. 96: 1121-9. PMID 16417581 DOI: 10.1111/J.1471-4159.2005.03605.X  0.355
2005 Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. Journal of Neurochemistry. 95: 210-20. PMID 16181425 DOI: 10.1111/J.1471-4159.2005.03357.X  0.347
2005 Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease. Journal of Neurochemistry. 95: 553-62. PMID 16135087 DOI: 10.1111/J.1471-4159.2005.03411.X  0.321
2005 Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proceedings of the National Academy of Sciences of the United States of America. 102: 11402-7. PMID 16076956 DOI: 10.1073/Pnas.0503634102  0.404
2005 Devon RS, Schwab C, Topp JD, Orban PC, Yang YZ, Pape TD, Helm JR, Davidson TL, Rogers DA, Gros-Louis F, Rouleau G, Horazdovsky BF, Leavitt BR, Hayden MR. Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood. Neurobiology of Disease. 18: 243-57. PMID 15686953 DOI: 10.1016/J.Nbd.2004.10.002  0.322
2004 Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/Sj.Cdd.4401358  0.33
2003 Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, Cataudella T, Leavitt BR, Hayden MR, Timmusk T, Rigamonti D, Cattaneo E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genetics. 35: 76-83. PMID 12881722 DOI: 10.1038/Ng1219  0.332
2003 Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Human Molecular Genetics. 12: 1555-67. PMID 12812983 DOI: 10.1093/Hmg/Ddg169  0.309
2003 Wellington CL, Ellerby LM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Huntington proteolysis in Huntington disease Clinical Neuroscience Research. 3: 129-139. DOI: 10.1016/S1566-2772(03)00055-0  0.308
2002 Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron. 33: 849-60. PMID 11906693 DOI: 10.1016/S0896-6273(02)00615-3  0.326
2001 Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science (New York, N.Y.). 293: 493-8. PMID 11408619 DOI: 10.1126/Science.1059581  0.369
2001 Clarke G, Collins RA, Leavitt BR, Andrews DF, Hayden MR, Lumsden CJ, McInnes RR. addendum: A one-hit model of cell death in inherited neuronal degenerations Nature. 409: 542-542. DOI: 10.1038/35054107  0.328
2000 Wellington CL, Leavitt BR, Hayden MR. Huntington disease: new insights on the role of huntingtin cleavage. Journal of Neural Transmission. Supplementum. 1-17. PMID 11128600 DOI: 10.1007/978-3-7091-6284-2_1  0.343
2000 Shin JJ, Fricker-Gates RA, Perez FA, Leavitt BR, Zurakowski D, Macklis JD. Transplanted neuroblasts differentiate appropriately into projection neurons with correct neurotransmitter and receptor phenotype in neocortex undergoing targeted projection neuron degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7404-16. PMID 11007899 DOI: 10.1523/Jneurosci.20-19-07404.2000  0.771
2000 Clarke G, Collins RA, Leavitt BR, Andrews DF, Hayden MR, Lumsden CJ, McInnes RR. A one-hit model of cell death in inherited neuronal degenerations. Nature. 406: 195-9. PMID 10910361 DOI: 10.1038/35018098  0.315
2000 Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 405: 951-5. PMID 10879536 DOI: 10.1038/35016083  0.769
1999 Catapano LA, Sheen VL, Leavitt BR, Macklis JD. Differentiation of transplanted neural precursors varies regionally in adults striatum. Neuroreport. 10: 3971-7. PMID 10716243 DOI: 10.1097/00001756-199912160-00045  0.711
1999 Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, et al. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron. 23: 181-92. PMID 10402204 DOI: 10.1016/S0896-6273(00)80764-3  0.311
1999 Leavitt BR, Hernit-Grant CS, Macklis JD. Mature astrocytes transform into transitional radial glia within adult mouse neocortex that supports directed migration of transplanted immature neurons. Experimental Neurology. 157: 43-57. PMID 10222107 DOI: 10.1006/exnr.1999.6982  0.617
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