Bruno D. Chapsal, Ph.D. - Publications

Affiliations: 
2005 Stony Brook University, Stony Brook, NY, United States 

9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Ghosh AK, Chapsal BD. Design of the anti-HIV protease inhibitor darunavir Introduction to Biological and Small Molecule Drug Research and Development. 355-384. DOI: 10.1016/B978-0-12-397176-0.00013-3  0.64
2012 Ghosh AK, Chapsal BD, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2308-11. PMID 22364812 DOI: 10.1016/J.Bmcl.2012.01.061  0.64
2011 Ghosh AK, Chapsal BD, Parham GL, Steffey M, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H. Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. Journal of Medicinal Chemistry. 54: 5890-901. PMID 21800876 DOI: 10.1021/Jm200649P  0.64
2011 Ide K, Aoki M, Amano M, Koh Y, Yedidi RS, Das D, Leschenko S, Chapsal B, Ghosh AK, Mitsuya H. Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants. Antimicrobial Agents and Chemotherapy. 55: 1717-27. PMID 21282450 DOI: 10.1128/Aac.01540-10  0.64
2011 Ghosh AK, Chapsal BD, Baldridge A, Steffey MP, Walters DE, Koh Y, Amano M, Mitsuya H. Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation. Journal of Medicinal Chemistry. 54: 622-34. PMID 21194227 DOI: 10.1021/Jm1012787  0.64
2008 Ghosh AK, Chapsal BD, Baldridge A, Ide K, Koh Y, Mitsuya H. Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors. Organic Letters. 10: 5135-8. PMID 18928291 DOI: 10.1021/Ol8020308  0.64
2008 Ghosh AK, Chapsal BD, Weber IT, Mitsuya H. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Accounts of Chemical Research. 41: 78-86. PMID 17722874 DOI: 10.1021/Ar7001232  0.64
2006 Chapsal BD, Ojima I. Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation. Organic Letters. 8: 1395-8. PMID 16562900 DOI: 10.1021/Ol060181V  0.64
2006 Chapsal BD, Hua Z, Ojima I. Catalytic asymmetric transformations with fine-tunable biphenol-based monodentate ligands Tetrahedron Asymmetry. 17: 642-657. DOI: 10.1016/J.Tetasy.2005.12.035  0.64
Show low-probability matches.