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Ruslan Medzhitov, Ph.D - Publications

Affiliations: 
Immunobiology Yale University School of Medicine, New Haven, CT 
Area:
Immunology
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Year Citation  Score
2024 Meizlish ML, Kimura Y, Pope SD, Matta R, Kim C, Philip NH, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances. 10: eadk6906. PMID 38478620 DOI: 10.1126/sciadv.adk6906  0.711
2023 Hoagland DA, Rodríguez-Morales P, Mann AO, Yu S, Lai A, Vazquez AB, Pope SD, Lim J, Li S, Zhang X, Li MO, Medzhitov R, Franklin RA. Macrophages control pathological interferon responses during viral respiratory infection. Biorxiv : the Preprint Server For Biology. PMID 38168230 DOI: 10.1101/2023.12.16.572019  0.798
2023 Adler M, Chavan AR, Medzhitov R. Tissue Biology: In Search of a New Paradigm. Annual Review of Cell and Developmental Biology. PMID 37607470 DOI: 10.1146/annurev-cellbio-120420-113830  0.734
2023 Kopp EB, Agaronyan K, Licona-Limón I, Nish SA, Medzhitov R. Modes of type 2 immune response initiation. Immunity. 56: 687-694. PMID 37044059 DOI: 10.1016/j.immuni.2023.03.015  0.32
2022 Zhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Microenvironmental sensing by fibroblasts controls macrophage population size. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205360119. PMID 35930670 DOI: 10.1073/pnas.2205360119  0.796
2022 Agaronyan K, Sharma L, Vaidyanathan B, Glenn K, Yu S, Annicelli C, Wiggen TD, Penningroth MR, Hunter RC, Dela Cruz CS, Medzhitov R. Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. Immunity. 55: 895-911.e10. PMID 35483356 DOI: 10.1016/j.immuni.2022.04.001  0.331
2021 Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis BS, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, ... ... Medzhitov R, et al. γδ T cells regulate the intestinal response to nutrient sensing. Science (New York, N.Y.). 371. PMID 33737460 DOI: 10.1126/science.aba8310  0.721
2021 Meizlish ML, Franklin RA, Zhou X, Medzhitov R. Tissue Homeostasis and Inflammation. Annual Review of Immunology. PMID 33651964 DOI: 10.1146/annurev-immunol-061020-053734  0.736
2020 Kim DJ, Khoury-Hanold W, Jain PC, Klein J, Kong Y, Pope SD, Ge W, Medzhitov R, Iwasaki A. RUNX binding sites are enriched in herpesvirus genomes and RUNX1 overexpression leads to HSV-1 suppression. Journal of Virology. PMID 32878886 DOI: 10.1128/Jvi.00943-20  0.703
2020 Franklin RA, Medzhitov R. Untangling iNKT Cell Function in Adipose Tissue Homeostasis. Cell Metabolism. 32: 148-149. PMID 32755605 DOI: 10.1016/J.Cmet.2020.07.003  0.731
2020 Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, ... ... Medzhitov R, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature. PMID 32717743 DOI: 10.1038/S41586-020-2588-Y  0.371
2020 Rumpret M, Drylewicz J, Ackermans LJE, Borghans JAM, Medzhitov R, Meyaard L. Functional categories of immune inhibitory receptors. Nature Reviews. Immunology. PMID 32612208 DOI: 10.1038/S41577-020-0352-Z  0.4
2020 Hong JY, Lim J, Carvalho F, Cho JY, Vaidyanathan B, Yu S, Annicelli C, Ip WKE, Medzhitov R. Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids. Cell. 180: 847-861.e15. PMID 32142678 DOI: 10.1016/J.Cell.2020.02.018  0.314
2020 Adler M, Mayo A, Zhou X, Franklin RA, Meizlish ML, Medzhitov R, Kallenberger SM, Alon U. Principles of Cell Circuits for Tissue Repair and Fibrosis. Iscience. 23: 100841. PMID 32058955 DOI: 10.1016/J.Isci.2020.100841  0.744
2019 Demaria O, Cornen S, Daëron M, Morel Y, Medzhitov R, Vivier E. Publisher Correction: Harnessing innate immunity in cancer therapy. Nature. PMID 31745371 DOI: 10.1038/S41586-019-1758-2  0.317
2019 Demaria O, Cornen S, Daëron M, Morel Y, Medzhitov R, Vivier E. Harnessing innate immunity in cancer therapy. Nature. 574: 45-56. PMID 31578484 DOI: 10.1038/S41586-019-1593-5  0.429
2019 Luan H, Wang A, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, Ring A, Young L, Medzhitov R. GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. PMID 31402172 DOI: 10.1016/J.Cell.2019.07.033  0.366
2019 Wang A, Medzhitov R. Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia. Nature Immunology. 20: 666-667. PMID 31110313 DOI: 10.1038/S41590-019-0374-5  0.363
2019 Wang A, Medzhitov R. Counting Calories: The Cost of Inflammation. Cell. 177: 223-224. PMID 30951664 DOI: 10.1016/J.Cell.2019.03.022  0.382
2019 Allen NC, Philip NH, Hui L, Zhou X, Franklin RA, Kong Y, Medzhitov R. Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response. Science Signaling. 12. PMID 30837303 DOI: 10.1126/Scisignal.Aau1851  0.762
2019 Wang A, Pope SD, Weinstein JS, Yu S, Zhang C, Booth CJ, Medzhitov R. Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674681 DOI: 10.1073/Pnas.1820704116  0.732
2019 Hong JY, Vaidyanathan B, Cho JY, Medzhitov R. Abstract B162: Developmental programming of long-term immunity of CD8 T-cells by perinatal glucocorticoids Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B162  0.396
2018 Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medzhitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 30291189 DOI: 10.1073/Pnas.1806376115  0.325
2018 Pope SD, Medzhitov R. Emerging Principles of Gene Expression Programs and Their Regulation. Molecular Cell. 71: 389-397. PMID 30075140 DOI: 10.1016/J.Molcel.2018.07.017  0.721
2018 Adler M, Mayo A, Zhou X, Franklin RA, Jacox JB, Medzhitov R, Alon U. Endocytosis as a stabilizing mechanism for tissue homeostasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29429964 DOI: 10.1073/Pnas.1714377115  0.758
2018 Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Circuit Design Features of a Stable Two-Cell System. Cell. PMID 29398113 DOI: 10.1016/J.Cell.2018.01.015  0.747
2017 Dai X, Medzhitov R. Inflammation: Memory beyond immunity. Nature. PMID 29045392 DOI: 10.1038/Nature24154  0.302
2017 Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, ... ... Medzhitov R, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine. PMID 28692063 DOI: 10.1038/Nm.4361  0.475
2017 Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science (New York, N.Y.). 356: 513-519. PMID 28473584 DOI: 10.1126/Science.Aal3535  0.319
2016 Luan HH, Medzhitov R. Food Fight: Role of Itaconate and Other Metabolites in Antimicrobial Defense. Cell Metabolism. 24: 379-87. PMID 27626199 DOI: 10.1016/J.Cmet.2016.08.013  0.389
2016 Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 166: 1512-1525.e12. PMID 27610573 DOI: 10.1016/J.Cell.2016.07.026  0.335
2016 Pope SD, Medzhitov R. GENE EXPRESSION. Unwinding inducible gene expression. Science (New York, N.Y.). 352: 1058-9. PMID 27230367 DOI: 10.1126/Science.Aag0365  0.72
2016 Okabe Y, Medzhitov R. Wormhole Travel for Macrophages. Cell. 165: 518-519. PMID 27104973 DOI: 10.1016/J.Cell.2016.04.005  0.318
2016 Vivier E, Medzhitov R. Editorial overview: Innate immunity. Current Opinion in Immunology. 38: v-vii. PMID 26739338 DOI: 10.1016/J.Coi.2015.12.005  0.402
2016 Franklin RA, Pope SD, Medzhitov R. Abstract A127: The role of macrophages in tissue homeostasis Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A127  0.753
2015 Okabe Y, Medzhitov R. Tissue biology perspective on macrophages. Nature Immunology. 17: 9-17. PMID 26681457 DOI: 10.1038/Ni.3320  0.381
2015 Ip WK, Medzhitov R. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nature Communications. 6: 6931. PMID 25959047 DOI: 10.1038/Ncomms7931  0.418
2015 Florsheim E, Yu S, Bragatto I, Faustino L, Gomes E, Ramos RN, Barbuto JA, Medzhitov R, Russo M. Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin. Journal of Immunology (Baltimore, Md. : 1950). 194: 4621-30. PMID 25876764 DOI: 10.4049/Jimmunol.1402493  0.348
2015 Iwasaki A, Medzhitov R. Control of adaptive immunity by the innate immune system. Nature Immunology. 16: 343-53. PMID 25789684 DOI: 10.1038/Ni.3123  0.461
2015 Rakoff-Nahoum S, Kong Y, Kleinstein SH, Subramanian S, Ahern PP, Gordon JI, Medzhitov R. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proceedings of the National Academy of Sciences of the United States of America. 112: 1929-36. PMID 25691701 DOI: 10.1073/Pnas.1424886112  0.374
2015 Su T, Bondar T, Zhou X, Zhang C, He H, Medzhitov R. Two-signal requirement for growth-promoting function of Yap in hepatocytes. Elife. 4. PMID 25667983 DOI: 10.7554/Elife.02948  0.452
2014 Rosenstein RK, Bezbradica JS, Yu S, Medzhitov R. Signaling pathways activated by a protease allergen in basophils. Proceedings of the National Academy of Sciences of the United States of America. 111: E4963-71. PMID 25369937 DOI: 10.1073/Pnas.1418959111  0.392
2014 Rivas FV, Chervonsky AV, Medzhitov R. ART and immunology. Trends in Immunology. 35: 451. PMID 25261059 DOI: 10.1016/J.It.2014.09.002  0.429
2014 Okabe Y, Medzhitov R. How the immune system spots tumors. Elife. 3: e04476. PMID 25250710 DOI: 10.7554/Elife.04476  0.371
2014 Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 513: 559-63. PMID 25043024 DOI: 10.1038/Nature13490  0.373
2014 Nish SA, Schenten D, Wunderlich FT, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R. T cell-intrinsic role of IL-6 signaling in primary and memory responses. Elife. 3: e01949. PMID 24842874 DOI: 10.7554/Elife.01949  0.785
2014 Okabe Y, Medzhitov R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell. 157: 832-44. PMID 24792964 DOI: 10.1016/J.Cell.2014.04.016  0.372
2014 Chovatiya R, Medzhitov R. Stress, inflammation, and defense of homeostasis. Molecular Cell. 54: 281-8. PMID 24766892 DOI: 10.1016/J.Molcel.2014.03.030  0.357
2014 Bezbradica JS, Rosenstein RK, DeMarco RA, Brodsky I, Medzhitov R. A role for the ITAM signaling module in specifying cytokine-receptor functions. Nature Immunology. 15: 333-42. PMID 24608040 DOI: 10.1038/Ni.2845  0.652
2014 Schenten D, Nish SA, Yu S, Yan X, Lee HK, Brodsky I, Pasman L, Yordy B, Wunderlich FT, Brüning JC, Zhao H, Medzhitov R. Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells. Immunity. 40: 78-90. PMID 24439266 DOI: 10.1016/J.Immuni.2013.10.023  0.678
2014 Chang PV, Hao L, Offermanns S, Medzhitov R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proceedings of the National Academy of Sciences of the United States of America. 111: 2247-52. PMID 24390544 DOI: 10.1073/Pnas.1322269111  0.458
2014 Su T, Bondar T, Zhou X, Zhang C, He H, Medzhitov R. Author response: Two-signal requirement for growth-promoting function of Yap in hepatocytes Elife. DOI: 10.7554/Elife.02948.033  0.435
2014 Nish SA, Schenten D, Thomas Wunderlich F, Pope SD, Gao Y, Hoshi N, Yu S, Yan X, Lee HK, Pasman L, Brodsky I, Yordy B, Zhao H, Brüning J, Medzhitov R. Author response Elife. 2014. DOI: 10.7554/Elife.01949.025  0.764
2013 Medzhitov R. Septic shock: on the importance of being tolerant. Immunity. 39: 799-800. PMID 24238335 DOI: 10.1016/J.Immuni.2013.10.012  0.305
2013 Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity. 39: 976-85. PMID 24210353 DOI: 10.1016/J.Immuni.2013.10.006  0.441
2013 Gao Y, Nish SA, Jiang R, Hou L, Licona-Limón P, Weinstein JS, Zhao H, Medzhitov R. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity. 39: 722-32. PMID 24076050 DOI: 10.1016/J.Immuni.2013.08.028  0.391
2013 Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M. The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. The Journal of Experimental Medicine. 210: 1369-87. PMID 23752229 DOI: 10.1084/Jem.20122394  0.34
2013 Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (New York, N.Y.). 340: 1230-4. PMID 23618765 DOI: 10.1126/Science.1233632  0.337
2013 Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ. Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity. 38: 528-40. PMID 23499488 DOI: 10.1016/J.Immuni.2012.11.017  0.411
2013 Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R. Role of caspase-1 in regulation of triglyceride metabolism Proceedings of the National Academy of Sciences of the United States of America. 110: 4810-4815. PMID 23487794 DOI: 10.1073/Pnas.1301996110  0.312
2013 Palm NW, Medzhitov R. Role of the inflammasome in defense against venoms. Proceedings of the National Academy of Sciences of the United States of America. 110: 1809-14. PMID 23297192 DOI: 10.1073/Pnas.1221476110  0.423
2012 Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nature Communications. 3: 1120. PMID 23047678 DOI: 10.1038/Ncomms2113  0.419
2012 Okin D, Medzhitov R. Evolution of inflammatory diseases. Current Biology : Cb. 22: R733-40. PMID 22975004 DOI: 10.1016/J.Cub.2012.07.029  0.304
2012 Palm NW, Rosenstein RK, Medzhitov R. Allergic host defences. Nature. 484: 465-72. PMID 22538607 DOI: 10.1038/Nature11047  0.417
2012 Medzhitov R, Schneider DS, Soares MP. Disease tolerance as a defense strategy. Science (New York, N.Y.). 335: 936-41. PMID 22363001 DOI: 10.1126/Science.1214935  0.326
2012 Bezbradica JS, Medzhitov R. Role of ITAM signaling module in signal integration. Current Opinion in Immunology. 24: 58-66. PMID 22240121 DOI: 10.1016/J.Coi.2011.12.010  0.349
2011 Kotas ME, Lee HY, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R. Impact of CD1d deficiency on metabolism. Plos One. 6: e25478. PMID 21980475 DOI: 10.1371/Journal.Pone.0025478  0.351
2011 Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, GabryÅ¡ová L, Howes A, O'Garra A. Highlights of 10 years of immunology in Nature Reviews Immunology. Nature Reviews. Immunology. 11: 693-702. PMID 21941295 DOI: 10.1038/Nri3063  0.387
2011 Iwasaki A, Medzhitov R. A new shield for a cytokine storm. Cell. 146: 861-2. PMID 21925310 DOI: 10.1016/J.Cell.2011.08.027  0.358
2011 Nish S, Medzhitov R. Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity. 34: 629-36. PMID 21616433 DOI: 10.1016/J.Immuni.2011.05.009  0.363
2011 Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. Journal of Immunology (Baltimore, Md. : 1950). 186: 6990-8. PMID 21593379 DOI: 10.4049/Jimmunol.1100396  0.396
2011 Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. Journal of Immunology (Baltimore, Md. : 1950). 186: 7080-8. PMID 21572023 DOI: 10.4049/Jimmunol.1003687  0.444
2011 Schenten D, Medzhitov R. The control of adaptive immune responses by the innate immune system. Advances in Immunology. 109: 87-124. PMID 21569913 DOI: 10.1016/B978-0-12-387664-5.00003-0  0.451
2011 Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB. A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. Plos Pathogens. 7: e1002026. PMID 21533069 DOI: 10.1371/Journal.Ppat.1002026  0.665
2011 Abraham C, Medzhitov R. Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology. 140: 1729-37. PMID 21530739 DOI: 10.1053/J.Gastro.2011.02.012  0.449
2011 Brodsky IE, Medzhitov R. Pyroptosis: macrophage suicide exposes hidden invaders. Current Biology : Cb. 21: R72-5. PMID 21256438 DOI: 10.1016/J.Cub.2010.12.008  0.659
2010 Medzhitov R. Innate immunity: quo vadis? Nature Immunology. 11: 551-3. PMID 20562835 DOI: 10.1038/Ni0710-551  0.397
2010 Brodsky IE, Palm NW, Sadanand S, Ryndak MB, Sutterwala FS, Flavell RA, Bliska JB, Medzhitov R. A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host & Microbe. 7: 376-87. PMID 20478539 DOI: 10.1016/J.Chom.2010.04.009  0.658
2010 Bondar T, Medzhitov R. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell. 6: 309-22. PMID 20362536 DOI: 10.1016/J.Stem.2010.03.002  0.344
2010 Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell. 140: 771-6. PMID 20303867 DOI: 10.1016/J.Cell.2010.03.006  0.389
2010 Bortoluci KR, Medzhitov R. Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cellular and Molecular Life Sciences : Cmls. 67: 1643-51. PMID 20229126 DOI: 10.1007/S00018-010-0335-5  0.443
2010 Jamieson AM, Yu S, Annicelli CH, Medzhitov R. Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host & Microbe. 7: 103-14. PMID 20159617 DOI: 10.1016/J.Chom.2010.01.010  0.411
2010 Sokol CL, Medzhitov R. Role of basophils in the initiation of Th2 responses. Current Opinion in Immunology. 22: 73-7. PMID 20144855 DOI: 10.1016/J.Coi.2010.01.012  0.434
2010 Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science (New York, N.Y.). 327: 291-5. PMID 20075244 DOI: 10.1126/Science.1183021  0.469
2010 Sokol CL, Medzhitov R. Emerging functions of basophils in protective and allergic immune responses Mucosal Immunology. 3: 129-137. PMID 20072123 DOI: 10.1038/mi.2009.137  0.347
2009 Kopp EB, Medzhitov R. Infection and inflammation in somatic maintenance, growth and longevity. Evolutionary Applications. 2: 132-41. PMID 25567853 DOI: 10.1111/J.1752-4571.2008.00062.X  0.308
2009 Medzhitov R, Horng T. Transcriptional control of the inflammatory response. Nature Reviews. Immunology. 9: 692-703. PMID 19859064 DOI: 10.1038/Nri2634  0.389
2009 Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metabolism. 10: 249-59. PMID 19808018 DOI: 10.1016/J.Cmet.2009.08.013  0.305
2009 Medzhitov R. Damage control in host-pathogen interactions. Proceedings of the National Academy of Sciences of the United States of America. 106: 15525-6. PMID 19805209 DOI: 10.1073/Pnas.0908451106  0.346
2009 Sansonetti PJ, Medzhitov R. Learning tolerance while fighting ignorance. Cell. 138: 416-20. PMID 19665961 DOI: 10.1016/J.Cell.2009.07.024  0.357
2009 Hargreaves DC, Horng T, Medzhitov R. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 138: 129-45. PMID 19596240 DOI: 10.1016/J.Cell.2009.05.047  0.708
2009 Medzhitov R. Approaching the asymptote: 20 years later. Immunity. 30: 766-75. PMID 19538928 DOI: 10.1016/J.Immuni.2009.06.004  0.406
2009 Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nature Immunology. 10: 713-20. PMID 19465907 DOI: 10.1038/Ni.1738  0.392
2009 Brodsky IE, Medzhitov R. Targeting of immune signalling networks by bacterial pathogens. Nature Cell Biology. 11: 521-6. PMID 19404331 DOI: 10.1038/Ncb0509-521  0.693
2009 Bezbradica JS, Medzhitov R. Integration of cytokine and heterologous receptor signaling pathways. Nature Immunology. 10: 333-9. PMID 19295629 DOI: 10.1038/Ni.1713  0.453
2009 Palm NW, Medzhitov R. Immunostimulatory activity of haptenated proteins. Proceedings of the National Academy of Sciences of the United States of America. 106: 4782-7. PMID 19255434 DOI: 10.1073/Pnas.0809403105  0.454
2009 Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunological Reviews. 227: 221-33. PMID 19120487 DOI: 10.1111/J.1600-065X.2008.00731.X  0.453
2009 Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nature Reviews. Cancer. 9: 57-63. PMID 19052556 DOI: 10.1038/Nrc2541  0.407
2009 Foster SL, Medzhitov R. Gene-specific control of the TLR-induced inflammatory response. Clinical Immunology (Orlando, Fla.). 130: 7-15. PMID 18964303 DOI: 10.1016/J.Clim.2008.08.015  0.427
2008 Rakoff-Nahoum S, Medzhitov R. Innate immune recognition of the indigenous microbial flora Mucosal Immunology. 1: S10-S14. PMID 19079220 DOI: 10.1038/Mi.2008.49  0.403
2008 Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 134: 587-98. PMID 18724932 DOI: 10.1016/J.Cell.2008.06.032  0.357
2008 Medzhitov R. Origin and physiological roles of inflammation. Nature. 454: 428-35. PMID 18650913 DOI: 10.1038/Nature07201  0.378
2008 Rakoff-Nahoum S, Medzhitov R. Role of toll-like receptors in tissue repair and tumorigenesis Biochemistry (Moscow). 73: 555-561. PMID 18605980 DOI: 10.1134/S0006297908050088  0.46
2008 Brodsky IE, Medzhitov R. Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. Plos Pathogens. 4: e1000067. PMID 18483548 DOI: 10.1371/Journal.Ppat.1000067  0.657
2008 Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunology. 9: 310-8. PMID 18300366 DOI: 10.1038/Ni1558  0.615
2008 Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nature Immunology. 9: 361-8. PMID 18297073 DOI: 10.1038/Ni1569  0.415
2008 Unni AM, Bondar T, Medzhitov R. Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proceedings of the National Academy of Sciences of the United States of America. 105: 1686-91. PMID 18223157 DOI: 10.1073/Pnas.0701675105  0.321
2007 Medzhitov R. TLR-mediated innate immune recognition. Seminars in Immunology. 19: 1-2. PMID 22228983 DOI: 10.1016/J.Smim.2007.02.001  0.421
2007 Stetson DB, Medzhitov R. T helper 17 cells get the NOD. Immunity. 27: 546-8. PMID 17967409 DOI: 10.1016/J.Immuni.2007.10.005  0.374
2007 Horng T, Bezbradica JS, Medzhitov R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nature Immunology. 8: 1345-52. PMID 17952078 DOI: 10.1038/Ni1524  0.358
2007 Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 449: 819-26. PMID 17943118 DOI: 10.1038/Nature06246  0.447
2007 Palm NW, Medzhitov R. Not so fast: adaptive suppression of innate immunity. Nature Medicine. 13: 1142-4. PMID 17917657 DOI: 10.1038/Nm1007-1142B  0.449
2007 Brodsky I, Medzhitov R. Two modes of ligand recognition by TLRs. Cell. 130: 979-81. PMID 17889640 DOI: 10.1016/J.Cell.2007.09.009  0.634
2007 Rakoff-Nahoum S, Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (New York, N.Y.). 317: 124-7. PMID 17615359 DOI: 10.1126/Science.1140488  0.352
2007 Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 447: 972-8. PMID 17538624 DOI: 10.1038/Nature05836  0.763
2007 Palm NW, Medzhitov R. Antifungal defense turns 17. Nature Immunology. 8: 549-51. PMID 17514204 DOI: 10.1038/Ni0607-549  0.43
2007 van Duin D, Allore HG, Mohanty S, Ginter S, Newman FK, Belshe RB, Medzhitov R, Shaw AC. Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. The Journal of Infectious Diseases. 195: 1590-7. PMID 17471428 DOI: 10.1086/516788  0.304
2007 van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC. Age-associated defect in human TLR-1/2 function. Journal of Immunology (Baltimore, Md. : 1950). 178: 970-5. PMID 17202359 DOI: 10.4049/Jimmunol.178.2.970  0.349
2007 Rakoff-Nahoum S, Medzhitov R. Prostaglandin-secreting cells: a portable first aid kit for tissue repair. The Journal of Clinical Investigation. 117: 83-6. PMID 17200710 DOI: 10.1172/Jci30865  0.328
2007 Kabelitz D, Medzhitov R. Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Current Opinion in Immunology. 19: 1-3. PMID 17157490 DOI: 10.1016/J.Coi.2006.11.018  0.414
2006 Liu B, Yang Y, Dai J, Medzhitov R, Freudenberg MA, Zhang PL, Li Z. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950). 177: 6880-8. PMID 17082602 DOI: 10.4049/Jimmunol.177.10.6880  0.431
2006 Blander JM, Medzhitov R. On regulation of phagosome maturation and antigen presentation. Nature Immunology. 7: 1029-35. PMID 16985500 DOI: 10.1038/Ni1006-1029  0.345
2006 Stetson DB, Medzhitov R. Type I interferons in host defense. Immunity. 25: 373-81. PMID 16979569 DOI: 10.1016/J.Immuni.2006.08.007  0.429
2006 Rakoff-Nahoum S, Medzhitov R. Role of the innate immune system and host-commensal mutualism Current Topics in Microbiology and Immunology. 308: 1-18. PMID 16922084 DOI: 10.1007/3-540-30657-9_1  0.376
2006 Stetson DB, Medzhitov R. Antiviral defense: interferons and beyond. The Journal of Experimental Medicine. 203: 1837-41. PMID 16880263 DOI: 10.1084/Jem.20061377  0.342
2006 Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity. 25: 319-29. PMID 16879997 DOI: 10.1016/J.Immuni.2006.06.010  0.446
2006 Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 125: 943-55. PMID 16751103 DOI: 10.1016/J.Cell.2006.03.047  0.425
2006 Czopik AK, Bynoe MS, Palm N, Raine CS, Medzhitov R. Semaphorin 7A is a negative regulator of T cell responses. Immunity. 24: 591-600. PMID 16713976 DOI: 10.1016/J.Immuni.2006.03.013  0.795
2006 Blander JM, Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature. 440: 808-12. PMID 16489357 DOI: 10.1038/Nature04596  0.404
2006 Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity. 24: 93-103. PMID 16413926 DOI: 10.1016/J.Immuni.2005.12.003  0.397
2006 Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nature Immunology. 7: 49-56. PMID 16341217 DOI: 10.1038/Ni1280  0.582
2006 Van Duin D, Medzhitov R, Shaw AC. Triggering TLR signaling in vaccination Trends in Immunology. 27: 49-55. PMID 16310411 DOI: 10.1016/J.It.2005.11.005  0.417
2006 Rakoff-Nahoum S, Medzhitov R. Role of Toll-like Receptors in Commensal Dependent Colitis Inflammatory Bowel Diseases. 12: S3. DOI: 10.1097/00054725-200604002-00010  0.322
2006 Pasare C, Medzhitov R. Immunology: Toll-like receptors and antibody responses (reply) Nature. 441: E4. DOI: 10.1038/Nature04876  0.375
2005 Hargreaves DC, Medzhitov R. Innate sensors of microbial infection Journal of Clinical Immunology. 25: 503-510. PMID 16380814 DOI: 10.1007/S10875-005-8065-4  0.722
2005 Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors Nature. 438: 364-368. PMID 16292312 DOI: 10.1038/Nature04267  0.46
2005 Soderberg KA, Payne GW, Sato A, Medzhitov R, Segal SS, Iwasaki A. Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proceedings of the National Academy of Sciences of the United States of America. 102: 16315-20. PMID 16260739 DOI: 10.1073/Pnas.0506190102  0.37
2005 Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nature Medicine. 11: 1173-9. PMID 16244651 DOI: 10.1038/Nm1315  0.351
2005 Zhang X, Shan P, Qureshi S, Homer R, Medzhitov R, Noble PW, Lee PJ. Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury Journal of Immunology. 175: 4834-4838. PMID 16210584 DOI: 10.4049/Jimmunol.175.8.4834  0.346
2005 Pasare C, Medzhitov R. Toll-like receptors: Linking innate and adaptive immunity Advances in Experimental Medicine and Biology. 560: 11-18. PMID 15932016 DOI: 10.1016/J.Micinf.2004.08.018  0.486
2005 Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Microbes and Infection. 6: 1382-7. PMID 15596124 DOI: 10.1016/j.micinf.2004.08.018  0.368
2005 Pasare C, Medzhitov R. Erratum: Toll-dependent control mechanisms of CD4 T cell activation (Immunity (2004) 21 (733-741) DOI: 10.1016/j.immuni.2005.03.001) Immunity. 22: 397-398. DOI: 10.1016/J.Immuni.2005.03.001  0.368
2005 Rakoff-Nahoum S, Medzhitov R. Role of toll-like receptor-commensal interactions in intestinal inflammation International Congress Series. 1285: 3-9. DOI: 10.1016/j.ics.2005.07.098  0.312
2004 Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation Immunity. 21: 733-741. PMID 15539158 DOI: 10.1016/J.Immuni.2004.10.006  0.439
2004 Munier AI, Medzhitov R, Janeway CA, Doucet D, Capovilla M, Lagueux M. graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochemistry and Molecular Biology. 34: 1025-35. PMID 15475297 DOI: 10.1016/J.Ibmb.2003.09.009  0.476
2004 Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology. 5: 987-95. PMID 15454922 DOI: 10.1038/Ni1112  0.493
2004 Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis Cell. 118: 229-241. PMID 15260992 DOI: 10.1016/J.Cell.2004.07.002  0.412
2004 Blander JM, Medzhitov R. Regulation of phagosome maturation by signals from toll-like receptors. Science (New York, N.Y.). 304: 1014-8. PMID 15143282 DOI: 10.1126/Science.1096158  0.435
2004 Barton GM, Medzhitov R. Toll signaling: RIPping off the TNF pathway. Nature Immunology. 5: 472-4. PMID 15116112 DOI: 10.1038/Ni0504-472  0.579
2004 Pasare C, Medzhitov R. Toll-like receptors and acquired immunity Seminars in Immunology. 16: 23-26. PMID 14751760 DOI: 10.1016/J.Smim.2003.10.006  0.47
2003 Pasare C, Medzhitov R. Toll-like receptors: Balancing host resistance with immune tolerance Current Opinion in Immunology. 15: 677-682. PMID 14630202 DOI: 10.1016/J.Coi.2003.09.002  0.479
2003 Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. The Journal of Experimental Medicine. 198: 513-20. PMID 12900525 DOI: 10.1084/Jem.20030162  0.356
2003 Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors Current Opinion in Immunology. 15: 396-401. PMID 12900270 DOI: 10.1016/S0952-7915(03)00080-3  0.46
2003 Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science (New York, N.Y.). 300: 1524-5. PMID 12791976 DOI: 10.1126/Science.1085536  0.656
2003 Barton GM, Medzhitov R. Linking Toll-like receptors to IFN-alpha/beta expression. Nature Immunology. 4: 432-3. PMID 12719735 DOI: 10.1038/Ni0503-432  0.559
2003 Qureshi ST, Medzhitov R. Toll-like receptors and their role in experimental models of microbial infection Genes and Immunity. 4: 87-94. PMID 12618855 DOI: 10.1038/Sj.Gene.6363937  0.445
2003 Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science. 299: 1033-1036. PMID 12532024 DOI: 10.1126/Science.1078231  0.456
2003 Medzhitov R, Biron CA. Editorial overviewInnate immunity Current Opinion in Immunology. 15. DOI: 10.1016/S0952-7915(02)00019-5  0.391
2002 Barton GM, Medzhitov R. Toll-like receptors and their ligands Current Topics in Microbiology and Immunology. 270: 81-92. PMID 12467245 DOI: 10.1007/978-3-642-59430-4_5  0.627
2002 Kopp E, Medzhitov R. Skin antibiotics get in the loop Nature Medicine. 8: 1359-1360. PMID 12457178 DOI: 10.1038/Nm1202-1359  0.371
2002 Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 420: 329-33. PMID 12447442 DOI: 10.1038/Nature01180  0.636
2002 Barton GM, Medzhitov R. Retroviral delivery of small interfering RNA into primary cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 14943-5. PMID 12417750 DOI: 10.1073/Pnas.242594499  0.538
2002 Kobayashi K, Hernandez LD, Galán JE, Janeway CA, Medzhitov R, Flavell RA. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110: 191-202. PMID 12150927 DOI: 10.1016/S0092-8674(02)00827-9  0.509
2002 Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine. 8: 878-84. PMID 12091878 DOI: 10.1038/Nm732  0.387
2002 Scanga CA, Aliberti J, Jankovic D, Tilloy F, Bennouna S, Denkers EY, Medzhitov R, Sher A. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 5997-6001. PMID 12055206 DOI: 10.4049/Jimmunol.168.12.5997  0.372
2002 Fan J, Kapus A, Marsden PA, Li YH, Oreopoulos G, Marshall JC, Frantz S, Kelly RA, Medzhitov R, Rotstein OD. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 168: 5252-9. PMID 11994482 DOI: 10.4049/Jimmunol.168.10.5252  0.345
2002 Barton GM, Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Current Opinion in Immunology. 14: 380-3. PMID 11973138 DOI: 10.1016/S0952-7915(02)00343-6  0.647
2002 Medzhitov R, Janeway CA. Decoding the patterns of self and nonself by the innate immune system. Science (New York, N.Y.). 296: 298-300. PMID 11951031 DOI: 10.1126/Science.1068883  0.563
2002 Kobayashi K, Inohara N, Hernandez LD, Galán JE, Núñez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 416: 194-9. PMID 11894098 DOI: 10.1038/416194A  0.634
2002 Bendelac A, Medzhitov R. Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity Journal of Experimental Medicine. 195: f19-f23. PMID 11877490 DOI: 10.1084/Jem.20020073  0.429
2002 Janeway CA, Medzhitov R. Innate immune recognition. Annual Review of Immunology. 20: 197-216. PMID 11861602 DOI: 10.1146/Annurev.Immunol.20.083001.084359  0.622
2001 Mushegian A, Medzhitov R. Evolutionary perspective on innate immune recognition Journal of Cell Biology. 155: 705-710. PMID 11724812 DOI: 10.1083/Jcb.200107040  0.408
2001 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 413: 732-8. PMID 11607032 DOI: 10.1038/35099560  0.425
2001 Horng T, Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway Proceedings of the National Academy of Sciences of the United States of America. 98: 12654-12658. PMID 11606776 DOI: 10.1073/Pnas.231471798  0.406
2001 Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nature Immunology. 2: 947-50. PMID 11547333 DOI: 10.1038/Ni712  0.653
2001 Horng T, Barton GM, Medzhitov R. TIRAP: An adapter molecule in the Toll signaling pathway Nature Immunology. 2: 835-841. PMID 11526399 DOI: 10.1038/Ni0901-835  0.616
2001 Li M, Carpio DF, Zheng Y, Bruzzo P, Singh V, Ouaaz F, Medzhitov RM, Beg AA. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 7128-35. PMID 11390458 DOI: 10.4049/Jimmunol.166.12.7128  0.318
2001 Medzhitov R. CpG DNA: Security code for host defense Nature Immunology. 2: 15-16. PMID 11135571 DOI: 10.1038/83121  0.349
2001 Medzhitov R. Toll-like receptors in innate immune recognition Biochemical Society Transactions. 29: A102-A102. DOI: 10.1042/Bst029A102  0.41
2001 Medzhitov R. Toll-like receptors and innate immunity Nature Reviews Immunology. 1: 135-145. DOI: 10.1038/35100529  0.47
2000 Medzhitov R, Janeway C. Fly immunity: great expectations Genome Biology. 1: REVIEWS106. PMID 11104525 DOI: 10.1186/Gb-2000-1-1-Reviews106  0.544
2000 Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature. 408: 111-5. PMID 11081518 DOI: 10.1038/35040600  0.364
2000 Medzhitov R, Janeway C. The Toll receptor family and microbial recognition. Trends in Microbiology. 8: 452-6. PMID 11044679 DOI: 10.1016/S0966-842X(00)01845-X  0.58
2000 Janeway C, Medzhitov R. Viral interference with IL-1 and toll signaling. Proceedings of the National Academy of Sciences of the United States of America. 97: 10682-3. PMID 11005852 DOI: 10.1073/Pnas.97.20.10682  0.551
2000 Schnare M, Holt AC, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Current Biology : Cb. 10: 1139-42. PMID 10996797 DOI: 10.1016/S0960-9822(00)00700-4  0.392
2000 Medzhitov R, Janeway C. Innate immunity. The New England Journal of Medicine. 343: 338-44. PMID 10922424 DOI: 10.1056/NEJM200008033430506  0.517
2000 Medzhitov R, Janeway CA. How does the immune system distinguish self from nonself? Seminars in Immunology. 12: 185-8; discussion 25. PMID 10910738 DOI: 10.1006/Smim.2000.0230  0.525
2000 Gatti E, Velleca MA, Biedermann BC, Ma W, Unternaehrer J, Ebersold MW, Medzhitov R, Pober JS, Mellman I. Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors. Journal of Immunology (Baltimore, Md. : 1950). 164: 3600-7. PMID 10725716 DOI: 10.4049/Jimmunol.164.7.3600  0.38
2000 Medzhitov R, Janeway C. Innate immune recognition: mechanisms and pathways. Immunological Reviews. 173: 89-97. PMID 10719670 DOI: 10.1034/J.1600-065X.2000.917309.X  0.61
1999 Medzhitov R, Janeway CA. Innate immune induction of the adaptive immune response. Cold Spring Harbor Symposia On Quantitative Biology. 64: 429-35. PMID 11232318  0.53
1999 Janeway CA, Medzhitov R. Lipoproteins take their toll on the host. Current Biology : Cb. 9: R879-82. PMID 10607553 DOI: 10.1016/S0960-9822(00)80073-1  0.557
1999 Janeway CA, Annicelli C, Appicelli J, Barlow A, Baron J, Carrithers M, Chen C, Chervonsky A, Cohen B, Dittel B, Evans T, Granata J, Hardardottir F, He X, Kaye J, ... ... Medzhitov R, et al. The role of self-recognition in receptor repertoire development Immunologic Research. 19: 107-118. PMID 10493166  0.508
1999 Blander JM, Visintin I, Janeway CA, Medzhitov R. Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites. Journal of Immunology (Baltimore, Md. : 1950). 163: 3746-52. PMID 10490970  0.468
1999 Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development. 13: 2059-71. PMID 10465784 DOI: 10.1101/Gad.13.16.2059  0.549
1999 Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. The Journal of Clinical Investigation. 104: 271-80. PMID 10430608 DOI: 10.1172/Jci6709  0.38
1999 Kopp EB, Medzhitov R. The Toll-receptor family and control of innate immunity Current Opinion in Immunology. 11: 13-18. PMID 10047546 DOI: 10.1016/S0952-7915(99)80003-X  0.445
1998 Medzhitov R, Janeway CA. Innate immune recognition and control of adaptive immune responses. Seminars in Immunology. 10: 351-3. PMID 9799709 DOI: 10.1006/Smim.1998.0136  0.605
1998 Janeway CA, Medzhitov R. Introduction: the role of innate immunity in the adaptive immune response Seminars in Immunology. 10: 349-50. PMID 9799708 DOI: 10.1006/Smim.1998.0142  0.586
1998 Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Molecular Cell. 2: 253-8. PMID 9734363 DOI: 10.1016/S1097-2765(00)80136-7  0.572
1998 Chervonsky AV, Medzhitov RM, Denzin LK, Barlow AK, Rudensky AY, Janeway CA. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 95: 10094-9. PMID 9707606 DOI: 10.1073/Pnas.95.17.10094  0.573
1998 Medzhitov R, Janeway CA. An ancient system of host defense. Current Opinion in Immunology. 10: 12-5. PMID 9523104 DOI: 10.1016/S0952-7915(98)80024-1  0.532
1998 Medzhitov R, Janeway CA. Self-defense: the fruit fly style. Proceedings of the National Academy of Sciences of the United States of America. 95: 429-30. PMID 9435208 DOI: 10.1073/Pnas.95.2.429  0.628
1997 Hong SC, Sant'Angelo DB, Dittel BN, Medzhitov R, Yoon ST, Waterbury PG, Janeway CA. The orientation of a T cell receptor to its MHC class II:peptide ligands. Journal of Immunology (Baltimore, Md. : 1950). 159: 4395-402. PMID 9379037  0.399
1997 Medzhitov R, Janeway CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 91: 295-8. PMID 9363937 DOI: 10.1016/S0092-8674(00)80412-2  0.596
1997 Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388: 394-7. PMID 9237759 DOI: 10.1038/41131  0.602
1997 Medzhitov R, Janeway CA. Innate immunity: impact on the adaptive immune response. Current Opinion in Immunology. 9: 4-9. PMID 9039775 DOI: 10.1016/S0952-7915(97)80152-5  0.592
1997 Medzhitov R, Janeway CA. Reply to Silverstein and Rose "On the mystique of the immunological self" Immunological Reviews. 159: 208-210. DOI: 10.1111/J.1600-065X.1997.Tb01018.X  0.433
1996 Medzhitov R, Janeway CA. On the semantics of immune recognition. Research in Immunology. 147: 208-14. PMID 8844897 DOI: 10.1016/0923-2494(96)87222-1  0.489
1996 Janeway CA, Goodnow CC, Medzhitov R. Danger - pathogen on the premises! Immunological tolerance. Current Biology : Cb. 6: 519-22. PMID 8805259 DOI: 10.1016/S0960-9822(02)00531-6  0.554
1996 Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong SC, Janeway CA. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity. 4: 367-76. PMID 8612131 DOI: 10.1016/S1074-7613(00)80250-2  0.493
Low-probability matches (unlikely to be authored by this person)
2015 Kotas ME, Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell. 160: 816-27. PMID 25723161 DOI: 10.1016/J.Cell.2015.02.010  0.3
2013 Bondar T, Medzhitov R. The origins of tumor-promoting inflammation. Cancer Cell. 24: 143-4. PMID 23948294 DOI: 10.1016/J.Ccr.2013.07.016  0.297
2008 Medzhitov R, Littman D. HIV immunology needs a new direction. Nature. 455: 591. PMID 18833256 DOI: 10.1038/455591A  0.288
2009 Bezbradica JS, Medzhitov R. Erratum: Corrigendum: Integration of cytokine and heterologous receptor signaling pathways Nature Immunology. 10: 665-665. DOI: 10.1038/Ni0609-665A  0.28
2004 MEDZHITOV R. Toll-like receptors and control of mammalian immunity*1 Journal of Allergy and Clinical Immunology. 113: S52. DOI: 10.1016/j.jaci.2003.12.150  0.279
2019 Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science (New York, N.Y.). 363. PMID 30630899 DOI: 10.1126/Science.Aar3932  0.278
2012 Colegio OR, Medzhitov R. TLR signaling and tumour-associated macrophages Tumour-Associated Macrophages. 2147483647: 119-133. DOI: 10.1007/978-1-4614-0662-4_9  0.277
2016 Okin D, Medzhitov R. The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia. Cell. PMID 26997483 DOI: 10.1016/J.Cell.2016.02.023  0.274
2003 Jude BA, Pobezinskaya Y, Bishop J, Parke S, Medzhitov RM, Chervonsky AV, Golovkina TV. Subversion of the innate immune system by a retrovirus. Nature Immunology. 4: 573-8. PMID 12730691 DOI: 10.1038/Ni926  0.27
2012 Hoshi N, Medzhitov R. Germs gone wild. Nature Medicine. 18: 654-6. PMID 22561817 DOI: 10.1038/Nm.2767  0.269
2022 Lim J, Lin EV, Hong JY, Vaidyanathan B, Erickson SA, Annicelli C, Medzhitov R. Induction of natural IgE by glucocorticoids. The Journal of Experimental Medicine. 219. PMID 36098746 DOI: 10.1084/jem.20220903  0.268
2010 Nish S, Schenten D, Hoshi N, Medzhitov R. E12 Role of innate immune signaling pathways in the development of colitis Journal of Crohn's and Colitis Supplements. 4: 9-10. DOI: 10.1016/S1873-9954(10)70016-1  0.268
2006 Qureshi ST, Zhang X, Aberg E, Bousette N, Giaid A, Shan P, Medzhitov RM, Lee PJ. Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 176: 4950-8. PMID 16585591  0.263
2007 Finlay BB, Medzhitov R. Host-microbe interactions: fulfilling a niche. Cell Host & Microbe. 1: 3-4. PMID 18005674 DOI: 10.1016/J.Chom.2007.02.004  0.262
2013 Medzhitov R. Pattern recognition theory and the launch of modern innate immunity. Journal of Immunology (Baltimore, Md. : 1950). 191: 4473-4. PMID 24141853 DOI: 10.4049/Jimmunol.1302427  0.261
2020 Kim DJ, Venkataraman A, Jain PC, Wiesler EP, DeBlasio M, Klein J, Tu SS, Lee S, Medzhitov R, Iwasaki A. Vitamin B12 and folic acid alleviate symptoms of nutritional deficiency by antagonizing aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571957 DOI: 10.1073/Pnas.2006949117  0.256
2020 Ye JJ, Bian X, Lim J, Medzhitov R. Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids. Proceedings of the National Academy of Sciences of the United States of America. PMID 32632018 DOI: 10.1073/Pnas.1922270117  0.255
2023 Florsheim EB, Bachtel ND, Cullen J, Lima BGC, Godazgar M, Carvalho F, Chatain CP, Zimmer MR, Zhang C, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature. PMID 37437602 DOI: 10.1038/s41586-023-06362-4  0.254
2023 Florsheim EB, Bachtel ND, Cullen J, Lima BGC, Godazgar M, Zhang C, Carvalho F, Gautier G, Launay P, Wang A, Dietrich MO, Medzhitov R. Immune sensing of food allergens promotes aversive behaviour. Biorxiv : the Preprint Server For Biology. PMID 36712030 DOI: 10.1101/2023.01.19.524823  0.246
2014 Uzhachenko R, Ivanov SV, Yarbrough WG, Shanker A, Medzhitov R, Ivanova AV. Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxidants & Redox Signaling. 20: 1533-47. PMID 24328503 DOI: 10.1089/Ars.2013.5437  0.243
2015 Medzhitov R. Bringing Warburg to lymphocytes. Nature Reviews. Immunology. 15: 598. PMID 26403193 DOI: 10.1038/Nri3918  0.243
2023 Hong JY, Medzhitov R. On developmental programming of the immune system. Trends in Immunology. 44: 877-889. PMID 37852863 DOI: 10.1016/j.it.2023.09.004  0.239
2021 Huen SC, Wang A, Feola K, Desrouleaux R, Luan HH, Hogg R, Zhang C, Zhang QJ, Liu ZP, Medzhitov R. Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation. The Journal of Experimental Medicine. 218. PMID 34406362 DOI: 10.1084/jem.20202151  0.239
2023 Adler M, Moriel N, Goeva A, Avraham-Davidi I, Mages S, Adams TS, Kaminski N, Macosko EZ, Regev A, Medzhitov R, Nitzan M. Emergence of division of labor in tissues through cell interactions and spatial cues. Cell Reports. 42: 112412. PMID 37086403 DOI: 10.1016/j.celrep.2023.112412  0.237
2015 Jacox JB, Medzhitov R. Abstract 2367A: CSF1-dependent macrophage-stromal fibroblast interactions determine tumor stability Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-2367A  0.235
2002 Kopp E, Medzhitov R. A plague on host defense Journal of Experimental Medicine. 196: 1009-1012. PMID 12391011 DOI: 10.1084/Jem.20021311  0.23
2012 Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling. Journal of Immunology (Baltimore, Md. : 1950). 189: 3150-8. PMID 22896629 DOI: 10.4049/Jimmunol.1201140  0.229
2023 Klein J, Wood J, Jaycox J, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, ... ... Medzhitov R, et al. Distinguishing features of Long COVID identified through immune profiling. Nature. PMID 37748514 DOI: 10.1038/s41586-023-06651-y  0.223
2008 Foster SL, Hargreaves DC, Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications (Nature (2007) 447, (972-978)) Nature. 451: 102. DOI: 10.1038/nature06541  0.219
2007 Blander JM, Medzhitov R. Blander and Medzhitov reply [2] Nature Immunology. 8: 217-218. DOI: 10.1038/Ni0307-217B  0.218
2021 Medzhitov R. The spectrum of inflammatory responses. Science (New York, N.Y.). 374: 1070-1075. PMID 34822279 DOI: 10.1126/science.abi5200  0.216
2022 Klein J, Wood J, Jaycox J, Lu P, Dhodapkar RM, Gehlhausen JR, Tabachnikova A, Tabacof L, Malik AA, Kamath K, Greene K, Monteiro VS, Peña-Hernandez M, Mao T, Bhattacharjee B, ... ... Medzhitov R, et al. Distinguishing features of Long COVID identified through immune profiling. Medrxiv : the Preprint Server For Health Sciences. PMID 35982667 DOI: 10.1101/2022.08.09.22278592  0.216
2016 Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, ... ... Medzhitov R, et al. Training the next generation of biomedical investigators in glycosciences. The Journal of Clinical Investigation. 126: 405-408. PMID 26829621 DOI: 10.1172/Jci85905  0.211
2012 Palm N, Medzhitov R. Learn to love those allergies New Scientist. 216: 30-31. DOI: 10.1016/S0262-4079(12)63126-1  0.205
2023 Wang S, Li K, Pickholz E, Dobie R, Matchett KP, Henderson NC, Carrico C, Driver I, Borch Jensen M, Chen L, Petitjean M, Bhattacharya D, Fiel MI, Liu X, Kisseleva T, ... ... Medzhitov R, et al. An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis. Science Translational Medicine. 15: eadd3949. PMID 36599008 DOI: 10.1126/scitranslmed.add3949  0.179
2003 Medzhitov R. Charles A. Janeway, Jr. 1943-2003 Nature Immunology. 4: 502-502. DOI: 10.1038/Ni0603-502  0.17
2013 Chovatiya R, Medzhitov R. Honor thy Go(na)ds. Immunology and Cell Biology. 91: 597-8. PMID 24060964 DOI: 10.1038/Icb.2013.50  0.16
2016 Medzhitov R, Belkaid Y, Davis MM, Glimcher L, O'Neill LAJ, Sallusto F. Immunology Gets out of the Box Cell. 165: 763-764. DOI: 10.1016/j.cell.2016.04.053  0.143
2015 Burrows MP, Volchkov P, Kobayashi KS, Chervonsky AV, Medzhitov R. Microbiota regulates type 1 diabetes through Toll-like receptors Proceedings of the National Academy of Sciences of the United States of America. 112: 9973-9977. DOI: 10.1073/pnas.1508740112  0.142
2017 Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV. Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging. PMID 28351997 DOI: 10.18632/aging.101213  0.121
2024 I Kutyavin V, Korn LL, Medzhitov R. Nutrient-derived signals regulate eosinophil adaptation to the small intestine. Proceedings of the National Academy of Sciences of the United States of America. 121: e2316446121. PMID 38271336 DOI: 10.1073/pnas.2316446121  0.12
2017 Medzhitov R. Ruslan Medzhitov Current Biology. 27: R577-R578. DOI: 10.1016/j.cub.2017.04.062  0.12
2019 Ye J, Medzhitov R. Control strategies in systemic metabolism. Nature Metabolism. 1: 947-957. PMID 32694839 DOI: 10.1038/s42255-019-0118-8  0.11
2012 Gordon JI, Dewey KG, Mills DA, Medzhitov RM. The human gut microbiota and undernutrition. Science Translational Medicine. 4: 137ps12. PMID 22674549 DOI: 10.1126/Scitranslmed.3004347  0.107
2022 Mitson-Salazar A, Medzhitov R. Environmental sensing mechanisms in intestinal homeostasis. The Journal of Allergy and Clinical Immunology. PMID 35820536 DOI: 10.1016/j.jaci.2022.06.019  0.097
2021 Florsheim EB, Sullivan ZA, Khoury-Hanold W, Medzhitov R. Food allergy as a biological food quality control system. Cell. PMID 33450204 DOI: 10.1016/j.cell.2020.12.007  0.078
2011 Medzhitov R. Innovating immunology: an interview with Ruslan Medzhitov. Disease Models & Mechanisms. 4: 430-2. PMID 21708899 DOI: 10.1242/dmm.008151  0.071
2019 Ye J, Medzhitov R. Control strategies in systemic metabolism Nature Metabolism. 1: 947-957. DOI: 10.1038/s42255-019-0118-8  0.063
2022 Adler M, Medzhitov R. Emergence of dynamic properties in network hypermotifs. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204967119. PMID 35914142 DOI: 10.1073/pnas.2204967119  0.041
2021 Bloom JD, Chan YA, Baric RS, Bjorkman PJ, Cobey S, Deverman BE, Fisman DN, Gupta R, Iwasaki A, Lipsitch M, Medzhitov R, Neher RA, Nielsen R, Patterson N, Stearns T, et al. Investigate the origins of COVID-19. Science (New York, N.Y.). 372: 694. PMID 33986172 DOI: 10.1126/science.abj0016  0.024
2013 Medzhitov R. Ruslan Medzhitov: Meet the winner of the Else Kröner-Fresenius Award in 2013. European Journal of Immunology. 43: 2792-4. PMID 24258908 DOI: 10.1002/eji.201370115  0.02
2011 Medzhitov RD, Panasenko PV, Knyazev KI, Kondrat'yev AV. The horizontally polarized X-band omnidirectional slot antenna Crimico 2011 - 2011 21st International Crimean Conference: Microwave and Telecommunication Technology, Conference Proceedings. 535-536.  0.019
2011 Semenin SN, Medzhitov RD, Panasenko PV, Knyazev KI, Evstifeev SF. Ka-band circular wavegude-dielectric antenna Crimico 2011 - 2011 21st International Crimean Conference: Microwave and Telecommunication Technology, Conference Proceedings. 569-570.  0.017
2014 Semenin SN, Medzhitov RD, Kolmakova NG. X-band microstrip antenna with 45% bandwidth Crimico 2014 - 2014 24th International Crimean Conference Microwave and Telecommunication Technology, Conference Proceedings. 489-490. DOI: 10.1109/CRMICO.2014.6959493  0.017
2001 Pal'shin NA, Vanyan LL, Medzhitov RD, Shapiro GI, Evdoshenko MA, Utada H, Shimizu H, Tanaka Y. Use of the Nakhodka-Naoetsu submarine cable for studying the temporal variability of the integral water transport in the sea of Japan Oceanology. 41: 447-453.  0.017
2011 Medzhitov RD, Panasenko PV, Knyazev KI, Evstifeev SF. Printed antennae of millimeter range with circular and linear polarization Crimico 2011 - 2011 21st International Crimean Conference: Microwave and Telecommunication Technology, Conference Proceedings. 571-572.  0.016
2011 Semenin SN, Panasenko PV, Medzhitov RD, Knyazev KI, Evstifeev SF. Omnidirectional printed patch collinear antenna arrays of vertical polarization Crimico 2011 - 2011 21st International Crimean Conference: Microwave and Telecommunication Technology, Conference Proceedings. 539-540.  0.016
2013 Medzhitov R. The Else Kröner-Fresenius Award announced European Journal of Immunology. 43: 1685-1685. DOI: 10.1002/eji.201370075  0.012
2011 Medzhitov RD, Panasenko PV, Knyazev KI, Kondratiev AV. X-band printed antenna array with vertical polarization Crimico 2011 - 2011 21st International Crimean Conference: Microwave and Telecommunication Technology, Conference Proceedings. 537-538.  0.011
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