Brad J. Geddes - Publications

Affiliations: 
Elixir Pharmaceuticals, Cambridge, MA, United States 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, ... Geddes BJ, et al. Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity (Journal of Pharmacology and Experimental Therapeutics (2011) 339, (115-124)) Journal of Pharmacology and Experimental Therapeutics. 340: 810.  0.537
2011 Longo KA, Govek EK, Nolan A, McDonagh T, Charoenthongtrakul S, Giuliana DJ, Morgan K, Hixon J, Zhou C, Kelder B, Kopchick JJ, Saunders JO, Navia MA, Curtis R, DiStefano PS, ... Geddes BJ, et al. Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. The Journal of Pharmacology and Experimental Therapeutics. 339: 115-24. PMID 21775475 DOI: 10.1124/Jpet.111.183764  0.577
2011 Qi Y, Longo KA, Giuliana DJ, Gagne S, McDonagh T, Govek E, Nolan A, Zou C, Morgan K, Hixon J, Saunders JO, Distefano PS, Geddes BJ. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. Bmc Physiology. 11: 1. PMID 21211044 DOI: 10.1186/1472-6793-11-1  0.554
2010 Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Distefano PS, Geddes BJ. The 24-hour respiratory quotient predicts energy intake and changes in body mass. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 298: R747-54. PMID 20018821 DOI: 10.1152/Ajpregu.00476.2009  0.524
2010 Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ. Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency. Growth Hormone & Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society. 20: 73-9. PMID 19747867 DOI: 10.1016/J.Ghir.2009.08.002  0.527
2009 Charoenthongtrakul S, Giuliana D, Longo KA, Govek EK, Nolan A, Gagne S, Morgan K, Hixon J, Flynn N, Murphy BJ, Hernández AS, Li J, Tino JA, Gordon DA, DiStefano PS, ... Geddes BJ, et al. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 329: 1178-86. PMID 19252061 DOI: 10.1124/Jpet.108.150193  0.516
2008 Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, Qi Y, DiStefano PS, Geddes BJ. Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regulatory Peptides. 150: 55-61. PMID 18453014 DOI: 10.1016/J.Regpep.2008.03.011  0.566
2007 DiStefano PS, Curtis R, Geddes BJ. Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan. Current Alzheimer Research. 4: 153-7. PMID 17430240 DOI: 10.2174/156720507780362038  0.537
2002 Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. The Journal of Biological Chemistry. 277: 29874-80. PMID 12019269 DOI: 10.1074/Jbc.M203915200  0.565
2002 Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. The Journal of Biological Chemistry. 277: 13952-8. PMID 11821383 DOI: 10.1074/Jbc.M107811200  0.546
2002 Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, Mak S, Lora JM, Briskin M, Jurman M, Cao J, DiStefano PS, Bertin J. PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. The Journal of Biological Chemistry. 277: 11570-5. PMID 11786556 DOI: 10.1074/Jbc.M112208200  0.55
2001 Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochemical and Biophysical Research Communications. 284: 77-82. PMID 11374873 DOI: 10.1006/bbrc.2001.4928  0.529
1999 Geddes BJ, Harding TC, Lightman SL, Uney JB. Assessing viral gene therapy in neuroendocrine models. Frontiers in Neuroendocrinology. 20: 296-316. PMID 10569280 DOI: 10.1006/Frne.1999.0184  0.619
1999 Uney J, Harding T, Geddes B. Targeting the Hypothalamus: Curing Salt Loss In Brattleboro Rats Biochemical Society Transactions. 27: A139-A139. DOI: 10.1042/Bst027A139  0.531
1999 Warburton EC, Geddes B, Harding T, Uney JB. Chapter 3.2.3 Regulatable adenoviral technology in behavioural neuroscience Techniques in the Behavioral and Neural Sciences. 13: 415-424. DOI: 10.1016/S0921-0709(99)80035-2  0.598
1998 Beaucamp N, Harding TC, Geddes BJ, Williams J, Uney JB. Overexpression of hsp70i facilitates reactivation of intracellular proteins in neurones and protects them from denaturing stress. Febs Letters. 441: 215-9. PMID 9883887 DOI: 10.1016/S0014-5793(98)01553-1  0.577
1998 Harding TC, Geddes BJ, Murphy D, Knight D, Uney JB. Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system. Nature Biotechnology. 16: 553-5. PMID 9624686 DOI: 10.1038/Nbt0698-553  0.611
1997 Geddes BJ, Harding TC, Lightman SL, Uney JB. Long-term gene therapy in the CNS: reversal of hypothalamic diabetes insipidus in the Brattleboro rat by using an adenovirus expressing arginine vasopressin. Nature Medicine. 3: 1402-4. PMID 9396613 DOI: 10.1038/Nm1297-1402  0.615
1997 Harding TC, Geddes BJ, Noel JD, Murphy D, Uney JB. Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors. Journal of Neurochemistry. 69: 2620-3. PMID 9375698 DOI: 10.1046/J.1471-4159.1997.69062620.X  0.615
1996 Geddes BJ, Harding TC, Hughes DS, Byrnes AP, Lightman SL, Conde G, Uney JB. Persistent transgene expression in the hypothalamus following stereotaxic delivery of a recombinant adenovirus: suppression of the immune response with cyclosporin. Endocrinology. 137: 5166-9. PMID 8895393 DOI: 10.1210/Endo.137.11.8895393  0.603
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