Charles S. Craik - Publications

Affiliations: 
1985- University of California, San Francisco, San Francisco, CA 
Area:
Molecular Biology, Genetics, Biochemistry
Website:
https://profiles.ucsf.edu/charles.craik

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biological Chemistry. PMID 31256057 DOI: 10.1515/hsz-2019-0103  0.32
2018 Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant S, Helander J, Klefström J, Craik CS, Janetka JW. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. Journal of Medicinal Chemistry. PMID 30571119 DOI: 10.1021/acs.jmedchem.8b01536  0.32
2018 Moroz A, Lee CY, Wang YH, Hsiao JC, Sevillano N, Truillet C, Craik CS, Fong L, Wang CI, Evans MJ. A preclinical assessment of 89Zr-atezolizumab identifies a requirement for carrier added formulations not observed with 89Zr-C4. Bioconjugate Chemistry. PMID 30227708 DOI: 10.1021/acs.bioconjchem.8b00632  0.4
2018 Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Scientific Reports. 8: 10705. PMID 30013126 DOI: 10.1038/s41598-018-29058-6  0.4
2018 Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. Substrate Specificity of Cysteine Proteases Beyond the S Pocket: Mutagenesis and Molecular Dynamics Investigation of Cathepsins L. Frontiers in Molecular Biosciences. 5: 40. PMID 29725596 DOI: 10.3389/fmolb.2018.00040  0.32
2018 Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. Plos Neglected Tropical Diseases. 12: e0006446. PMID 29677188 DOI: 10.1371/journal.pntd.0006446  0.32
2017 Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. Elife. 6. PMID 29182146 DOI: 10.7554/eLife.27364  0.32
2017 Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS. Global substrate specificity profiling of post-translational modifying enzymes. Protein Science : a Publication of the Protein Society. PMID 29168252 DOI: 10.1002/pro.3352  0.32
2017 Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely CM, Sevillano N, Wang YH, Shen YS, Olivas V, Jami K, Moroz A, Jego B, ... ... Craik CS, et al. Imaging PD-L1 expression with immunoPET. Bioconjugate Chemistry. PMID 29125731 DOI: 10.1021/acs.bioconjchem.7b00631  0.4
2017 Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thrombosis and Haemostasis. 117. PMID 28726978 DOI: 10.1160/TH17-02-0081  0.4
2017 Wilkinson DJ, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD. Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo: multiple mechanisms promote cartilage damage in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28464560 DOI: 10.1002/art.40133  0.4
2017 Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider M, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim G, O'Donoghue AJ, Kirkwood KS, Craik CS. Global protease activity profiling provides differential diagnosis of pancreatic cysts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28424202 DOI: 10.1158/1078-0432.CCR-16-2987  0.32
2017 Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved Across Commensal Bacteria. Acs Chemical Biology. PMID 28414448 DOI: 10.1021/acschembio.7b00143  0.32
2017 Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS. Multiplex Substrate Profiling by Mass Spectrometry for Kinases Reveals Quantitative Substrate Motifs. Analytical Chemistry. PMID 28322550 DOI: 10.1021/acs.analchem.6b05002  0.32
2016 Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. Plos Pathogens. 12: e1006051. PMID 27977806 DOI: 10.1371/journal.ppat.1006051  0.32
2016 Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27739665 DOI: 10.1021/acsinfecdis.6b00092  0.32
2016 O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors. Biological Chemistry. PMID 27149201 DOI: 10.1515/hsz-2016-0138  0.32
2016 Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proceedings of the National Academy of Sciences of the United States of America. PMID 27006500 DOI: 10.1073/pnas.1524900113  0.32
2016 Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 530: 233-6. PMID 26863983 DOI: 10.1038/nature16936  0.32
2016 Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. Chemmedchem. PMID 26822284 DOI: 10.1002/cmdc.201500526  1
2015 Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nature Communications. 6: 8448. PMID 26423607 DOI: 10.1038/ncomms9448  1
2015 Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. PMID 26409899 DOI: 10.1016/j.biochi.2015.09.025  0.32
2015 O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 7478-83. PMID 25944934 DOI: 10.1073/pnas.1507082112  1
2015 Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB. Ecotin: Exploring a feasible antithrombotic profile. International Journal of Biological Macromolecules. 78: 296-303. PMID 25881959 DOI: 10.1016/j.ijbiomac.2015.03.071  1
2015 Kim JM, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter Nature. 517: 396-400. PMID 25363761 DOI: 10.1038/nature13872  1
2015 Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor. The Biochemical Journal. 465: 163-73. PMID 25279554 DOI: 10.1042/BJ20140809  1
2015 O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. Correction: Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome (Proceedings of the National Academy of Sciences United State of America (2015) 112, (7478-7483) DOI: 10.1073/pnas.1507082112) Proceedings of the National Academy of Sciences of the United States of America. 112: E3152. DOI: 10.1073/pnas.1509071112  1
2014 Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P. Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. The Journal of Biological Chemistry. 289: 34267-83. PMID 25326387 DOI: 10.1074/jbc.M114.598201  1
2014 Gable JE, Acker TM, Craik CS. Current and Potential Treatments for Ubiquitous but Neglected Herpesvirus Infections. Chemical Reviews. PMID 25275644 DOI: 10.1021/cr500255e  1
2014 Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. Acs Nano. 8: 9199-208. PMID 25166742 DOI: 10.1021/nn502959q  1
2014 Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 53: 4648-60. PMID 24977643 DOI: 10.1021/bi5003234  1
2014 Tajon C, Jun YW, Craik CS. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology. Methods in Enzymology. 544: 271-97. PMID 24974294 DOI: 10.1016/B978-0-12-417158-9.00011-X  1
2014 Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. The Journal of Biological Chemistry. 289: 12791-804. PMID 24644284 DOI: 10.1074/jbc.M113.498576  1
2014 LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF. Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. Theranostics. 4: 267-79. PMID 24505235 DOI: 10.7150/thno.7323  1
2014 Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discovery. 4: 200-15. PMID 24362263 DOI: 10.1158/2159-8290.CD-13-0235  1
2013 Du X, Chen NL, Wong A, Craik CS, Brömme D. Elastin degradation by cathepsin V requires two exosites. The Journal of Biological Chemistry. 288: 34871-81. PMID 24121514 DOI: 10.1074/jbc.M113.510008  1
2013 O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. Plos One. 8: e75141. PMID 24073241 DOI: 10.1371/journal.pone.0075141  1
2013 Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica Plos Neglected Tropical Diseases. 7. PMID 23875031 DOI: 10.1371/journal.pntd.0002269  1
2013 Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 288: 12489-99. PMID 23504313 DOI: 10.1074/jbc.M113.456541  1
2013 Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. The Journal of Biological Chemistry. 288: 10588-98. PMID 23447538 DOI: 10.1074/jbc.M112.449033  1
2013 LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Research. 73: 2070-81. PMID 23400595 DOI: 10.1158/0008-5472.CAN-12-3526  1
2013 LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proceedings of the National Academy of Sciences of the United States of America. 110: 93-8. PMID 23248318 DOI: 10.1073/pnas.1218694110  1
2013 Shahian T, Craik CS. Kaposi's Sarcoma Virus Assemblin (Herpesvirus 8-type Assemblin) Handbook of Proteolytic Enzymes. 3: 3545-3550. DOI: 10.1016/B978-0-12-382219-2.00784-5  1
2013 Page MJ, Craik CS. Brachyurins Handbook of Proteolytic Enzymes. 3: 3049-3052. DOI: 10.1016/B978-0-12-382219-2.00669-4  1
2013 Baird TT, Craik CS. Trypsin Handbook of Proteolytic Enzymes. 3: 2594-2600. DOI: 10.1016/B978-0-12-382219-2.00575-5  1
2012 Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 51: 10087-98. PMID 23181936 DOI: 10.1021/bi301305k  1
2012 O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. Global identification of peptidase specificity by multiplex substrate profiling. Nature Methods. 9: 1095-100. PMID 23023596 DOI: 10.1038/nmeth.2182  1
2012 Craik CS, Shahian T. A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor. Methods in Molecular Biology (Clifton, N.J.). 928: 119-31. PMID 22956137 DOI: 10.1007/978-1-62703-008-3_9  1
2012 Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L97-106. PMID 22582115 DOI: 10.1152/ajplung.00303.2011  1
2012 Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). The Journal of Biological Chemistry. 287: 21152-63. PMID 22539347 DOI: 10.1074/jbc.M112.347922  1
2012 Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. Plos Neglected Tropical Diseases. 6: e1589. PMID 22509414 DOI: 10.1371/journal.pntd.0001589  1
2012 Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, ... ... Craik CS, et al. Fabs enable single particle cryoEM studies of small proteins. Structure (London, England : 1993). 20: 582-92. PMID 22483106 DOI: 10.1016/j.str.2012.02.017  1
2012 Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM. Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference. Biochimie. 94: 1119-27. PMID 22285967 DOI: 10.1016/j.biochi.2012.01.011  1
2012 Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, ... ... Craik CS, et al. Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 481: 371-5. PMID 22190037 DOI: 10.1038/nature10693  1
2012 Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, ... ... Craik CS, et al. Global landscape of HIV-human protein complexes. Nature. 481: 365-70. PMID 22190034 DOI: 10.1038/nature10719  1
2012 Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS. A reverse binding motif that contributes to specific protease inhibition by antibodies. Journal of Molecular Biology. 415: 699-715. PMID 22154938 DOI: 10.1016/j.jmb.2011.11.036  1
2012 Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS. Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis. The Prostate. 72: 846-55. PMID 21919028 DOI: 10.1002/pros.21486  1
2011 Kim J, Stroud RM, Craik CS. Rapid identification of recombinant Fabs that bind to membrane proteins Methods. 55: 303-309. PMID 21958987 DOI: 10.1016/j.ymeth.2011.09.012  1
2011 Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Research. 92: 187-94. PMID 21820471 DOI: 10.1016/j.antiviral.2011.07.016  1
2011 Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. International Journal For Parasitology. 41: 1253-62. PMID 21819989 DOI: 10.1016/j.ijpara.2011.06.006  1
2011 Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ. GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data. Bmc Bioinformatics. 12: 298. PMID 21777475 DOI: 10.1186/1471-2105-12-298  1
2011 Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. Enzyme inhibition by allosteric capture of an inactive conformation. Journal of Molecular Biology. 411: 999-1016. PMID 21723875 DOI: 10.1016/j.jmb.2011.06.032  1
2011 de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N. Human and mouse granzyme M display divergent and species-specific substrate specificities. The Biochemical Journal. 437: 431-42. PMID 21564021 DOI: 10.1042/BJ20110210  1
2011 Craik CS, Page MJ, Madison EL. Proteases as therapeutics. The Biochemical Journal. 435: 1-16. PMID 21406063 DOI: 10.1042/BJ20100965  1
2011 Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS. Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. Chemistry & Biology. 18: 48-57. PMID 21276938 DOI: 10.1016/j.chembiol.2010.11.007  1
2011 Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. The Journal of Biological Chemistry. 286: 429-40. PMID 20961853 DOI: 10.1074/jbc.M110.138313  1
2010 Farady CJ, Craik CS. Mechanisms of macromolecular protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 11: 2341-6. PMID 21053238 DOI: 10.1002/cbic.201000442  1
2010 Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. Plos Neglected Tropical Diseases. 4: e849. PMID 20967286 DOI: 10.1371/journal.pntd.0000849  1
2010 Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. Journal of Immunology (Baltimore, Md. : 1950). 185: 5360-8. PMID 20889553 DOI: 10.4049/jimmunol.1002292  1
2010 Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasites & Vectors. 3: 63. PMID 20663211 DOI: 10.1186/1756-3305-3-63  1
2010 Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Prediction of protease substrates using sequence and structure features. Bioinformatics (Oxford, England). 26: 1714-22. PMID 20505003 DOI: 10.1093/bioinformatics/btq267  1
2010 Duriseti S, Goetz DH, Hostetter DR, LeBeau AM, Wei Y, Craik CS. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. The Journal of Biological Chemistry. 285: 26878-88. PMID 20501655 DOI: 10.1074/jbc.M109.077677  1
2010 He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, ... ... Craik CS, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID 20378535 DOI: 10.1074/jbc.M109.086181  1
2010 Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host & Microbe. 7: 210-20. PMID 20227664 DOI: 10.1016/j.chom.2010.02.006  1
2010 Stoop AA, Joshi RV, Eggers CT, Craik CS. Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation. Biological Chemistry. 391: 425-33. PMID 20180651 DOI: 10.1515/BC.2010.047  1
2010 LeBeau AM, Kostova M, Craik CS, Denmeade SR. Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer. Biological Chemistry. 391: 333-43. PMID 20180648 DOI: 10.1515/BC.2010.044  1
2010 Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental Cell. 18: 25-38. PMID 20152175 DOI: 10.1016/j.devcel.2009.11.014  1
2010 Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Tumor detection by imaging proteolytic activity. Cancer Research. 70: 1505-12. PMID 20145119 DOI: 10.1158/0008-5472.CAN-09-1640  1
2010 Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. Acs Nano. 4: 978-84. PMID 20121209 DOI: 10.1021/nn900757p  1
2010 Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC. Engineering ecotin for identifying proteins with a trypsin fold. Applied Biochemistry and Biotechnology. 160: 2355-65. PMID 19728173 DOI: 10.1007/s12010-009-8711-z  1
2010 Doǧan MYS, Revyakin A, Park S, Pertsinidis A, Brown C, Chu S, Craik CS, Majumdar A. A new platform for profiling active proteases with single-molecule sensitivity Proceedings of the Asme 1st Global Congress On Nanoengineering For Medicine and Biology 2010, Nemb2010. 77-78.  1
2009 Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proceedings of the National Academy of Sciences of the United States of America. 106: 17735-40. PMID 19805121 DOI: 10.1073/pnas.0907367106  1
2009 Mckerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. Two approaches to discovering and developing new drugs for Chagas disease Memorias Do Instituto Oswaldo Cruz. 104: 263-269. PMID 19753483  1
2009 Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nature Chemical Biology. 5: 640-6. PMID 19633659 DOI: 10.1038/nchembio.192  1
2009 Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703. PMID 19620707 DOI: 10.1074/jbc.M109.014340  1
2009 Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology (Reading, England). 155: 3673-82. PMID 19556294 DOI: 10.1099/mic.0.030940-0  1
2009 Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 3: e449. PMID 19488406 DOI: 10.1371/journal.pntd.0000449  1
2009 Farady CJ, Sellers BD, Jacobson MP, Craik CS. Improving the species cross-reactivity of an antibody using computational design. Bioorganic & Medicinal Chemistry Letters. 19: 3744-7. PMID 19477127 DOI: 10.1016/j.bmcl.2009.05.005  1
2009 Schneider EL, Craik CS. Positional scanning synthetic combinatorial libraries for substrate profiling. Methods in Molecular Biology (Clifton, N.J.). 539: 59-78. PMID 19377970 DOI: 10.1007/978-1-60327-003-8_4  1
2009 Lee GM, Craik CS. Trapping moving targets with small molecules. Science (New York, N.Y.). 324: 213-5. PMID 19359579 DOI: 10.1126/science.1169378  1
2009 Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. Plos One. 4: e5156. PMID 19357776 DOI: 10.1371/journal.pone.0005156  1
2009 Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. The Journal of Biological Chemistry. 284: 13792-803. PMID 19297327 DOI: 10.1074/jbc.M900508200  1
2009 Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM. Substrate specificity of transthyretin: identification of natural substrates in the nervous system. The Biochemical Journal. 419: 467-74. PMID 19138167 DOI: 10.1042/BJ20082090  1
2009 Dolecková K, Kasný M, Mikes L, Cartwright J, Jedelský P, Schneider EL, Dvorák J, Mountford AP, Craik CS, Horák P. The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. International Journal For Parasitology. 39: 201-11. PMID 18708063 DOI: 10.1016/j.ijpara.2008.06.010  1
2009 Lim MD, Craik CS. Using specificity to strategically target proteases. Bioorganic & Medicinal Chemistry. 17: 1094-100. PMID 18434168 DOI: 10.1016/j.bmc.2008.03.068  1
2008 Raorane DA, Lim MD, Chen FF, Craik CS, Majumdar A. Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. Nano Letters. 8: 2968-74. PMID 18720973 DOI: 10.1021/nl8019455  1
2008 O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. The Journal of Biological Chemistry. 283: 28934-43. PMID 18701454 DOI: 10.1074/jbc.M805824200  1
2008 O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. The Journal of Biological Chemistry. 283: 29186-95. PMID 18687686 DOI: 10.1074/jbc.M802366200  1
2008 Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. Biological Chemistry. 389: 623-32. PMID 18627343 DOI: 10.1515/BC.2008.075  1
2008 Lucas JJ, Hayes GR, Kalsi HK, Gilbert RO, Choe Y, Craik CS, Singh BN. Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis. Archives of Biochemistry and Biophysics. 477: 239-43. PMID 18554499 DOI: 10.1016/j.abb.2008.05.018  1
2008 Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. Journal of Molecular Biology. 380: 351-60. PMID 18514224 DOI: 10.1016/j.jmb.2008.05.009  1
2008 DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. The Journal of Biological Chemistry. 283: 18024-31. PMID 18445589 DOI: 10.1074/jbc.M802133200  1
2008 Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908. PMID 18160404 DOI: 10.1074/jbc.M708521200  1
2008 Darragh MR, Bhatt AS, Craik CS. MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Frontiers in Bioscience : a Journal and Virtual Library. 13: 528-39. PMID 17981566 DOI: 10.2741/2698  1
2007 Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS. Substrate modulation of enzyme activity in the herpesvirus protease family. Journal of Molecular Biology. 373: 913-23. PMID 17870089 DOI: 10.1016/j.jmb.2007.07.073  1
2007 Hostetter DR, Loeb CR, Chu F, Craik CS. Hip is a pro-survival substrate of granzyme B. The Journal of Biological Chemistry. 282: 27865-74. PMID 17620340 DOI: 10.1074/jbc.M704312200  1
2007 Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 46: 8744-52. PMID 17605471 DOI: 10.1021/bi0621415  1
2007 Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). Journal of Molecular Biology. 369: 1041-51. PMID 17475279 DOI: 10.1016/j.jmb.2007.03.078  1
2007 Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 5771-6. PMID 17389401 DOI: 10.1073/pnas.0606514104  1
2007 Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal For Parasitology. 37: 713-24. PMID 17336985 DOI: 10.1016/j.ijpara.2006.12.020  1
2006 Chu F, Mahrus S, Craik CS, Burlingame AL. Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces. Journal of the American Chemical Society. 128: 10362-3. PMID 16895390 DOI: 10.1021/ja0614159  1
2006 Park K, Kuechle MK, Choe Y, Craik CS, Lawrence OT, Presland RB. Expression and characterization of constitutively active human caspase-14. Biochemical and Biophysical Research Communications. 347: 941-8. PMID 16854378 DOI: 10.1016/j.bbrc.2006.06.156  1
2006 Loeb CR, Harris JL, Craik CS. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis. The Journal of Biological Chemistry. 281: 28326-35. PMID 16798735 DOI: 10.1074/jbc.M604544200  1
2006 Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. The Embo Journal. 25: 2686-97. PMID 16763560 DOI: 10.1038/sj.emboj.7601173  1
2006 Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. The Journal of Biological Chemistry. 281: 25678-88. PMID 16740631 DOI: 10.1074/jbc.M602372200  1
2006 Baird TT, Wright WD, Craik CS. Conversion of trypsin to a functional threonine protease. Protein Science : a Publication of the Protein Society. 15: 1229-38. PMID 16672242 DOI: 10.1110/ps.062179006  1
2006 Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease. Biochemistry. 45: 3572-9. PMID 16533039 DOI: 10.1021/bi0523658  1
2006 Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. The Journal of Biological Chemistry. 281: 12824-32. PMID 16520377 DOI: 10.1074/jbc.M513331200  1
2005 Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. Induced structure of a helical switch as a mechanism to regulate enzymatic activity. Nature Structural & Molecular Biology. 12: 1019-20. PMID 16244665 DOI: 10.1038/nsmb1006  1
2005 Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM. Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene. 24: 5333-43. PMID 16007225 DOI: 10.1038/sj.onc.1208582  1
2005 Mahrus S, Craik CS. Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Chemistry & Biology. 12: 567-77. PMID 15911377 DOI: 10.1016/j.chembiol.2005.03.006  1
2005 Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. The Biochemical Journal. 390: 125-36. PMID 15839837 DOI: 10.1042/BJ20041955  1
2005 Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorganic & Medicinal Chemistry. 13: 2141-56. PMID 15727867 DOI: 10.1016/j.bmc.2004.12.053  1
2005 Marnett AB, Craik CS. Papa's got a brand new tag: advances in identification of proteases and their substrates. Trends in Biotechnology. 23: 59-64. PMID 15661339 DOI: 10.1016/j.tibtech.2004.12.010  1
2005 Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. The Prostate. 62: 1-13. PMID 15389820 DOI: 10.1002/pros.20101  1
2004 Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dötsch V. Optimization of 13C direct detection NMR methods. Journal of Biomolecular Nmr. 30: 175-9. PMID 15557804 DOI: 10.1023/B:JNMR.0000048855.35771.11  1
2004 Mahrus S, Kisiel W, Craik CS. Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B Journal of Biological Chemistry. 279: 54275-54282. PMID 15494398 DOI: 10.1074/jbc.M411482200  1
2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/jbc.M405842200  1
2004 Serber Z, Straub W, Corsini L, Nomura AM, Shimba N, Craik CS, Ortiz de Montellano P, Dötsch V. Methyl groups as probes for proteins and complexes in in-cell NMR experiments. Journal of the American Chemical Society. 126: 7119-25. PMID 15174883 DOI: 10.1021/ja049977k  1
2004 Shimba N, Nomura AM, Marnett AB, Craik CS. Herpesvirus protease inhibition by dimer disruption. Journal of Virology. 78: 6657-65. PMID 15163756 DOI: 10.1128/JVI.78.12.6657-6665.2004  1
2004 Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. The Journal of Biological Chemistry. 279: 30751-9. PMID 15123647 DOI: 10.1074/jbc.M400949200  1
2004 Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 101: 6870-5. PMID 15118083 DOI: 10.1073/pnas.0401613101  1
2004 Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. The Biochemical Journal. 379: 107-18. PMID 14705961 DOI: 10.1042/BJ20031790  1
2004 Byoung-Kuk NA, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax Biochemical Journal. 378: 529-538. PMID 14629194 DOI: 10.1042/BJ20031487  1
2003 Stoop AA, Craik CS. Engineering of a macromolecular scaffold to develop specific protease inhibitors Nature Biotechnology. 21: 1063-1068. PMID 12923547 DOI: 10.1038/nbt860  1
2003 Shimba N, Serber Z, Ledwidge R, Miller SM, Craik CS, Dötsch V. Quantitative identification of the protonation state of histidines in vitro and in vivo Biochemistry. 42: 9227-9234. PMID 12885258 DOI: 10.1021/bi0344679  1
2003 Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nature Structural Biology. 10: 527-34. PMID 12819769 DOI: 10.1038/nsb944  1
2003 Raymond WW, Ruggles SW, Craik CS, Caughey GH. Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. The Journal of Biological Chemistry. 278: 34517-24. PMID 12815038 DOI: 10.1074/jbc.M304087200  1
2003 Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells Biological Chemistry. 384: 257-266. PMID 12675519 DOI: 10.1515/BC.2003.029  1
2003 Mackewicz CE, Craik CS, Levy JA. The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 100: 3433-8. PMID 12624186 DOI: 10.1073/pnas.0630379100  1
2003 Shimba N, Stern AS, Craik CS, Hoch JC, Dötsch V. Elimination of 13Cα splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction Journal of the American Chemical Society. 125: 2382-2383. PMID 12603112 DOI: 10.1021/ja027973e  1
2003 Sun J, Pons J, Craik CS. Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies. Biochemistry. 42: 892-900. PMID 12549907 DOI: 10.1021/bi026878f  1
2003 Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. The Biochemical Journal. 371: 525-32. PMID 12529175 DOI: 10.1042/BJ20021643  1
2002 Barrios AM, Craik CS. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters. 12: 3619-23. PMID 12443789 DOI: 10.1016/S0960-894X(02)00786-2  1
2002 Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites Biochemical Journal. 368: 273-281. PMID 12169096 DOI: 10.1042/BJ20020753  1
2002 Wang X, Choe Y, Craik CS, Ellman JA. Design and synthesis of novel inhibitors of gelatinase B. Bioorganic & Medicinal Chemistry Letters. 12: 2201-4. PMID 12127537 DOI: 10.1016/S0960-894X(02)00365-7  1
2002 Lecaille F, Choe Y, Brandt W, Li Z, Craik CS, Brömme D. Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity Biochemistry. 41: 8447-8454. PMID 12081494 DOI: 10.1021/bi025638x  1
2002 Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. The Journal of Biological Chemistry. 277: 24618-24. PMID 11986325 DOI: 10.1074/jbc.M202364200  1
2002 Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries Molecular and Biochemical Parasitology. 121: 99-105. PMID 11985866 DOI: 10.1016/S0166-6851(02)00026-9  1
2002 Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. The Journal of Biological Chemistry. 277: 26623-31. PMID 11959867 DOI: 10.1074/jbc.M203076200  1
2002 Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM. Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry. 41: 4582-94. PMID 11926820 DOI: 10.1021/bi011781z  1
2002 Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5. PMID 11856036 DOI: 10.1021/jo016140o  1
2002 Wang B, Brown KC, Lodder M, Craik CS, Hecht SM. Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction. Biochemistry. 41: 2805-13. PMID 11851428 DOI: 10.1021/bi011762p  1
2002 Pray TR, Reiling KK, Demirjian BG, Craik CS. Conformational change coupling the dimerization and activation of KSHV protease Biochemistry. 41: 1474-1482. PMID 11814340 DOI: 10.1021/bi011753g  1
2002 Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. Journal of Virology. 76: 1359-68. PMID 11773410  1
2002 Chu F, Baker P, Mahrus S, Craik CS, Rosser M, Nicchitta CV, Burlingame AL. Probing protein-protein interactions with chemical cross-linking and differential nano-LC-MS Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 289-290.  1
2001 Person MD, Brown KC, Mahrus S, Craik CS, Burlingame AL. Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer Protein Science. 10: 1549-1562. PMID 11468352 DOI: 10.1110/ps.46601  1
2001 Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. Definition of the extended substrate specificity determinants for beta-tryptases I and II. The Journal of Biological Chemistry. 276: 34941-7. PMID 11438529 DOI: 10.1074/jbc.M102997200  1
2001 Eggers CT, Wang SX, Fletterick RJ, Craik CS. The role of ecotin dimerization in protease inhibition. Journal of Molecular Biology. 308: 975-91. PMID 11352586 DOI: 10.1006/jmbi.2001.4754  1
2001 Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation Nature Cell Biology. 3: 267-275. PMID 11231576 DOI: 10.1038/35060059  1
2001 Nealon K, Newcomb WW, Pray TR, Craik CS, Brown JC, Kedes DH. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Journal of Virology. 75: 2866-78. PMID 11222712 DOI: 10.1128/JVI.75.6.2866-2878.2001  1
2000 Reiling KK, Pray TR, Craik CS, Stroud RM. Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry. 39: 12796-803. PMID 11041844 DOI: 10.1021/bi001019h  1
2000 Waugh SM, Harris JL, Fletterick R, Craik CS. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity Nature Structural Biology. 7: 762-765. PMID 10966646 DOI: 10.1038/78992  1
2000 Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proceedings of the National Academy of Sciences of the United States of America. 97: 7754-9. PMID 10869434 DOI: 10.1073/pnas.140132697  1
2000 Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Journal of Molecular Biology. 299: 993-1003. PMID 10843853 DOI: 10.1006/jmbi.2000.3812  1
2000 Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. The Journal of Biological Chemistry. 275: 26333-42. PMID 10831593 DOI: 10.1074/jbc.M002941200  1
2000 Todd S, Anderson CG, Jolly DJ, Craik CS. HIV protease as a target for retrovirus vector-mediated gene therapy Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1477: 168-188. PMID 10708857 DOI: 10.1016/S0167-4838(99)00272-1  1
2000 Rozzelle JE, Dauber DS, Todd S, Kelley R, Craik CS. Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers Journal of Biological Chemistry. 275: 7080-7086. PMID 10702274 DOI: 10.1074/jbc.275.10.7080  1
2000 Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18: 187-93. PMID 10657126 DOI: 10.1038/72642  1
2000 Todd S, Laboissière MCA, Craik CS. Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants Analytical Biochemistry. 277: 247-253. PMID 10625514 DOI: 10.1006/abio.1999.4388  1
2000 Wang B, Lodder M, Zhou J, Baird TT, Brown KC, Craik CS, Hecht SM. Chemically mediated site-specific cleavage of proteins [9] Journal of the American Chemical Society. 122: 7402-7403. DOI: 10.1021/ja0002262  1
2000 Baird T, Wang B, Lodder M, Hecht SM, Craik CS. Generation of active trypsin by chemical cleavage Tetrahedron. 56: 9477-9485.  1
1999 Takeuchi T, Shuman MA, Craik CS. Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue Proceedings of the National Academy of Sciences of the United States of America. 96: 11054-11061. PMID 10500122 DOI: 10.1073/pnas.96.20.11054  1
1999 Pray TR, Nomura AM, Pennington MW, Craik CS. Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease Journal of Molecular Biology. 289: 197-203. PMID 10366498 DOI: 10.1006/jmbi.1999.2791  1
1998 Harris JL, Peterson EP, Hudig D, Thornberry NA, Craik CS. Definition and redesign of the extended substrate specificity of granzyme B Journal of Biological Chemistry. 273: 27364-27373. PMID 9765264 DOI: 10.1074/jbc.273.42.27364  1
1998 Harris JL, Craik CS. Engineering enzyme specificity Current Opinion in Chemical Biology. 2: 127-132. PMID 9667915  1
1998 Yang SQ, Craik CS. Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator Journal of Molecular Biology. 279: 1001-1011. PMID 9642077 DOI: 10.1006/jmbi.1998.1749  1
1998 Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. Journal of Molecular Biology. 279: 945-57. PMID 9642073 DOI: 10.1006/jmbi.1998.1748  1
1998 Dauber DS, McPhee F, Ünal A, Craik CS. Optimization of a macromolecular inhibitor of HIV-1 protease Advances in Experimental Medicine and Biology. 436: 65-70. PMID 9561201  1
1998 Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Ünal A. Engineering catalytically defective forms of HIV protease to modulate its activity Advances in Experimental Medicine and Biology. 436: 31-39. PMID 9561196  1
1998 Brown KC, Yu Z, Burlingame AL, Craik CS. Determining protein - Protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein Biochemistry. 37: 4397-4406. PMID 9521759 DOI: 10.1021/bi9728046  1
1998 Rose RB, Craik CS, Stroud RM. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry. 37: 2607-21. PMID 9485411 DOI: 10.1021/bi9716074  1
1997 Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR. Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor. Bioorganic & Medicinal Chemistry. 5: 2019-27. PMID 9416419 DOI: 10.1016/S0968-0896(97)00131-4  1
1997 Babé LM, Craik CS. Viral proteases: Evolution of diverse structural motifs to optimize function Cell. 91: 427-430. PMID 9390549  1
1997 Perona JJ, Craik CS. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold Journal of Biological Chemistry. 272: 29987-29990. PMID 9374470 DOI: 10.1074/jbc.272.48.29987  1
1997 Ünal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) Journal of Virology. 71: 7030-7038. PMID 9261433  1
1997 Gillmor SA, Craik CS, Fletterick RJ. Structural determinants of specificity in the cysteine protease cruzain. Protein Science : a Publication of the Protein Society. 6: 1603-11. PMID 9260273 DOI: 10.1002/pro.5560060801  1
1997 Babe LM, Unal A, Craik CS. Obstruction of HIV-1 particle release by interferon-α occurs before viral protease processing and is independent of envelope glycoprotein Journal of Interferon and Cytokine Research. 17: 287-293. PMID 9181467  1
1997 Tsu CA, Perona JJ, Fletterick RJ, Craik CS. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 36: 5393-401. PMID 9154921 DOI: 10.1021/bi961753u  1
1997 Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 36: 5381-92. PMID 9154920 DOI: 10.1021/bi9617522  1
1997 Ewoldt GR, Smyth MJ, Darcy PK, Harris JL, Craik CS, Horowitz B, Woodard SL, Powers JC, Hudig D. P-4 and RNKP-7, New Granzyme-Like Serine Proteases Expressed in Activated Rat Lymphocytes Journal of Immunology. 158: 4574-4583. PMID 9144469  1
1997 Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Øie S. Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1-protease inhibitory activity Pharmaceutical Research. 14: 176-180. PMID 9090705 DOI: 10.1023/A:1012044526054  1
1997 Rutenher EE, Rose RH, Craik CS, Sirnud RM. Mechanism of hydrolysis of HIV-1 and SIV protease deduced from three-dimensional structures of genuine substrate and product complexes Faseb Journal. 11: A1033.  1
1997 Dauber DS, Craik CS. Optimization of a dominant negative inhibitor of HIV-1 protease Faseb Journal. 11: A1323.  1
1997 Craik CS, Dauber D, De Ortiz Montellano P, Rozzelle J, Unal A. Engineering catalytically defective HIV protease heterodimers as potential antivirals Faseb Journal. 11: A855.  1
1997 Laboissere MCA, Yang Q, Craik CS. Macromolecular inhibition of urokinase-type plasminogen activator Faseb Journal. 11: A1397.  1
1997 Craik CS, Cunha G, Elfman F, Shuman M, Takeuchi T, Yang O. Macromolecular inhibition of serine proteases associated with epithelial cancer Faseb Journal. 11: A1282.  1
1997 Rozzelle JE, Craik CS. Dominant-negative inhibitors of HIV-1 protease: Purification and biophysical characterization Faseb Journal. 11: A1401.  1
1996 McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. The Biochemical Journal. 320: 681-6. PMID 8973584  1
1996 Gudmundsdóttir E, Spilliaert R, Yang Q, Craik CS, Bjarnason JB, Gudmundsdóttir A. Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 113: 795-801. PMID 8925447 DOI: 10.1016/0305-0491(95)02109-4  1
1996 Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC, Craik CS, Stroud RM. A new class of HIV-1 protease inhibitor: The crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere Bioorganic and Medicinal Chemistry. 4: 1545-1558. PMID 8894111 DOI: 10.1016/0968-0896(96)00147-2  1
1996 Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, et al. Structure-based design of parasitic protease inhibitors. Bioorganic & Medicinal Chemistry. 4: 1421-7. PMID 8894100 DOI: 10.1016/0968-0896(96)00136-8  1
1996 Junker U, Escaich S, Plavec I, Baker J, McPhee F, Rosé JR, Craik CS, Böhnlein E. Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor- resistant HIV-1 strains in human T-cell lines Journal of Virology. 70: 7765-7772. PMID 8892897  1
1996 McPhee F, Good AC, Kuntz ID, Craik CS. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. Proceedings of the National Academy of Sciences of the United States of America. 93: 11477-81. PMID 8876160 DOI: 10.1073/pnas.93.21.11477  1
1996 Rose RB, Craik CS, Douglas NL, Stroud RM. Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry. 35: 12933-44. PMID 8841139 DOI: 10.1021/bi9612733  1
1996 Wang CI, Yang Q, Craik CS. Phage display of proteases and macromolecular inhibitors Methods in Enzymology. 267: 52-68. PMID 8743309 DOI: 10.1016/S0076-6879(96)67005-0  1
1996 Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 35: 5999-6009. PMID 8634241 DOI: 10.1021/bi9530200  1
1996 Willett WS, Brinen LS, Fletterick RJ, Craik CS. Delocalizing trypsin specificity with metal activation. Biochemistry. 35: 5992-8. PMID 8634240 DOI: 10.1021/bi9530191  1
1996 Tsu CA, Craik CS. Substrate recognition by recombinant serine collagenase 1 from Uca pugilator. The Journal of Biological Chemistry. 271: 11563-70. PMID 8626718 DOI: 10.1074/jbc.271.19.11563  1
1996 Ewoldt GR, Smyth MJ, Darcytf PK, Harris JL, Craik CS, Hudig D. Cloning and modeling of new granzymes Faseb Journal. 10: A1038.  1
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