Mark R. Kelley - Publications

Affiliations: 
Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Molecular Biology, Biochemistry

180 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gampala S, Moon HR, Wireman R, Peil J, Kiran S, Mitchell DK, Brewster K, Mang H, Masters A, Bach C, Smith-Kinnamen W, Doud EH, Rai R, Mosley AL, Quinney SK, ... ... Kelley MR, et al. New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types. Pharmacological Research. 107092. PMID 38311014 DOI: 10.1016/j.phrs.2024.107092  0.307
2023 Mijit M, Boner M, Cordova RA, Gampala S, Kpenu E, Klunk AJ, Zhang C, Kelley MR, Staschke KA, Fishel ML. Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment. Frontiers in Medicine. 10: 1146115. PMID 37181357 DOI: 10.3389/fmed.2023.1146115  0.322
2023 Mijit M, Liu S, Sishtla K, Hartman GD, Wan J, Corson TW, Kelley MR. Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells. International Journal of Molecular Sciences. 24. PMID 36674619 DOI: 10.3390/ijms24021101  0.385
2022 Behrouzi A, Kelley MR, Fehrenbacher JC. Oxidative DNA Damage: A Role in Altering Neuronal Function. Journal of Cellular Signaling. 3: 160-166. PMID 36204460 DOI: 10.33696/signaling.3.079  0.374
2022 Mijit M, Wireman R, Armstrong L, Gampala S, Hassan Z, Schneeweis C, Schneider G, Zhang C, Fishel ML, Kelley MR. RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells. Frontiers in Oncology. 12: 826617. PMID 35402225 DOI: 10.3389/fonc.2022.826617  0.375
2022 Behrouzi A, Xia H, Thompson EL, Kelley MR, Fehrenbacher JC. Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons. International Journal of Molecular Sciences. 23. PMID 35163831 DOI: 10.3390/ijms23031909  0.393
2021 Gampala S, Shah F, Lu X, Moon HR, Babb O, Ganesh NU, Sandusky G, Hulsey E, Armstrong L, Mosely AL, Han B, Ivan M, Yeh JJ, Kelley MR, Zhang C, et al. Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target. Journal of Experimental & Clinical Cancer Research : Cr. 40: 251. PMID 34376225 DOI: 10.1186/s13046-021-02046-x  0.343
2020 Caston RA, Gampala S, Armstrong L, Messmann RA, Fishel ML, Kelley MR. The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease. Drug Discovery Today. PMID 33148489 DOI: 10.1016/j.drudis.2020.10.015  0.368
2020 Sahakian L, Filippone RT, Stavely R, Robinson AM, Yan XS, Abalo R, Eri R, Bornstein JC, Kelley MR, Nurgali K. Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis. Inflammatory Bowel Diseases. PMID 32618996 DOI: 10.1093/Ibd/Izaa161  0.313
2019 Codrich M, Comelli M, Malfatti MC, Mio C, Ayyildiz D, Zhang C, Kelley MR, Terrosu G, Pucillo CEM, Tell G. Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway. Dna Repair. 82: 102675. PMID 31450087 DOI: 10.1016/J.Dnarep.2019.102675  0.426
2019 Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ. Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer. Molecular Cancer Therapeutics. PMID 31413178 DOI: 10.1158/1535-7163.Mct-18-1166  0.446
2019 Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan MH, Kelley MR, Tell G, Pucillo CEM. Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination. The Journal of Biological Chemistry. PMID 30705092 DOI: 10.1074/Jbc.Ra118.006601  0.468
2019 Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of macrocyclic inhibitors of Apurinic/apyrimidinic endonuclease 1. Journal of Medicinal Chemistry. PMID 30653918 DOI: 10.1021/Acs.Jmedchem.8B01529  0.518
2019 Chu L, Anderson AKL, Landers MA, Wang Y, Kelley MR, Messmann RA. CTC enumeration and characterization as a pharmacodynamic marker in the phase I clinical study of APX3330, an APE1/Ref-1 inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E14531  0.381
2019 Shahda S, Lakhani NJ, O'Neil B, Rasco DW, Wan J, Mosley AL, Liu H, Kelley MR, Messmann RA. A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors. Journal of Clinical Oncology. 37: 3097-3097. DOI: 10.1200/Jco.2019.37.15_Suppl.3097  0.346
2019 Kelley MR, Shahda S, Lakhani NJ, O'Neil B, Chu L, Anderson AK, Wan J, Mosley AL, Liu H, Messmann RA. Abstract PR01: A phase I study targeting the APE1/Ref-1 DNA repair-redox signaling protein with the APX3330 inhibitor Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Pr01  0.46
2018 Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell. 23: 833-849.e5. PMID 30526882 DOI: 10.1016/J.Stem.2018.10.013  0.329
2018 Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML. Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival. Scientific Reports. 8: 13759. PMID 30214007 DOI: 10.1038/S41598-018-32034-9  0.371
2018 Sardar Pasha SPB, Sishtla K, Sulaiman RS, Park B, Shetty T, Shah F, Fishel ML, Wikel JH, Kelley MR, Corson TW. Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization. The Journal of Pharmacology and Experimental Therapeutics. PMID 30076264 DOI: 10.1124/Jpet.118.248088  0.398
2018 McIlwain DW, Fishel ML, Boos A, Kelley MR, Jerde TJ. APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. Oncotarget. 9: 10962-10977. PMID 29541389 DOI: 10.18632/Oncotarget.23493  0.38
2018 Kelley MR, Messmann RA, Fehrenbacher J. Novel first-in-class small molecule targeting APE1/Ref-1 to prevent and treat chemotherapy-induced peripheral neuropathy (CIPN). Journal of Clinical Oncology. 36: 229-229. DOI: 10.1200/Jco.2018.36.34_Suppl.229  0.523
2018 Cai Z, Kotzin J, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali R, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R. Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis Blood. 132: 1288-1288. DOI: 10.1182/Blood-2018-99-116703  0.337
2018 Shah FL, Atallah N, Grimard M, Guo C, Zhang C, Fehrenbacher J, Kelley MR, Fishel M. Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach Cancer Research. 78: 4802-4802. DOI: 10.1158/1538-7445.Am2018-4802  0.482
2017 Fehrenbacher JC, Guo C, Kelley MR, Vasko MR. DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1. Neuroscience. PMID 28965839 DOI: 10.1016/J.Neuroscience.2017.09.039  0.432
2017 Shah F, Goossens E, Atallah NM, Grimard M, Kelley MR, Fishel ML. APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma: Characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing. Molecular Oncology. PMID 28922540 DOI: 10.1002/1878-0261.12138  0.411
2017 Shah F, Logsdon D, Messmann RA, Fehrenbacher JC, Fishel ML, Kelley MR. Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. Npj Precision Oncology. 1. PMID 28825044 DOI: 10.1038/s41698-017-0023-0  0.337
2017 Ding J, Fishel ML, Reed AM, McAdams E, Czader M, Cardoso AA, Kelley MR. Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia. Molecular Cancer Therapeutics. PMID 28446640 DOI: 10.1158/1535-7163.Mct-17-0099  0.364
2017 Kelley MR, Fehrenbacher JC. Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage. Neural Regeneration Research. 12: 72-74. PMID 28250749 DOI: 10.4103/1673-5374.198986  0.455
2016 Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR. Identification of new chemical entities targeting APE1 for the prevention of chemotherapy-induced peripheral neuropathy (CIPN). The Journal of Pharmacology and Experimental Therapeutics. PMID 27608656 DOI: 10.1124/Jpet.116.235283  0.453
2016 Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML. Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models. Molecular Cancer Therapeutics. PMID 27535970 DOI: 10.1158/1535-7163.Mct-16-0253  0.462
2016 Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR. Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons. Dna Repair. 41: 32-41. PMID 27078577 DOI: 10.1016/J.Dnarep.2016.03.009  0.473
2016 McElyea KC, Jacobsen MH, Schmidt M, Cheng H, Kelley MR, Sandusky GE, Fishel ML. Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model Cancer Research. 76: 5183-5183. DOI: 10.1158/1538-7445.Am2016-5183  0.527
2016 Fishel ML, Logsdon DP, Grimard ML, Supuran CT, Zyromski N, Ivan M, Kelley MR, Shah F. Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials Cancer Research. 76: 4740-4740. DOI: 10.1158/1538-7445.Am2016-4740  0.403
2015 Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH. APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER. Mutation Research. 779: 96-104. PMID 26164266 DOI: 10.1016/J.Mrfmmm.2015.06.010  0.478
2015 Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M, He Y, Yu Z, Tong Y, Lipking KP, Maitra A, Rajeshkumar NV, Scandura G, Kelley MR, Ivan M. Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2. The Journal of Biological Chemistry. 290: 3057-68. PMID 25492865 DOI: 10.1074/Jbc.M114.621995  0.499
2015 Fishel ML, Cheng H, Korc M, Kelley MR. Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B19  0.409
2015 Logsdon DP, Cheng H, Luo M, Shahda S, Hao Y, Tong Y, Yu Z, Zyromski N, Schipani E, Liu Y, Supuran CT, Ivan M, Kelley MR, Fishel ML. Abstract B158: Targeting APE1/Ref-1 results in inhibition of hypoxia signaling genes Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B158  0.302
2015 Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH. APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779: 96-104. DOI: 10.1016/j.mrfmmm.2015.06.010  0.314
2014 Kelley MR, Jiang Y, Guo C, Reed A, Meng H, Vasko MR. Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy. Plos One. 9: e106485. PMID 25188410 DOI: 10.1371/Journal.Pone.0106485  0.476
2014 Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X. Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity. Investigative Ophthalmology & Visual Science. 55: 4461-9. PMID 24970265 DOI: 10.1167/Iovs.14-14451  0.337
2014 Kelley MR, Logsdon D, Fishel ML. Targeting DNA repair pathways for cancer treatment: what's new? Future Oncology (London, England). 10: 1215-37. PMID 24947262 DOI: 10.2217/Fon.14.60  0.543
2014 Li Y, Liu X, Zhou T, Kelley MR, Edwards P, Gao H, Qiao X. Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization. Redox Biology. 2: 485-94. PMID 24624338 DOI: 10.1016/J.Redox.2014.01.023  0.352
2014 Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP. The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. Plos One. 9: e89232. PMID 24586617 DOI: 10.1371/Journal.Pone.0089232  0.319
2014 Cardoso AA, Wikel JH, Ding J, Reed AM, Luo M, Kelley MR. Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-B32  0.42
2013 Zhang J, Luo M, Marasco D, Logsdon D, LaFavers KA, Chen Q, Reed A, Kelley MR, Gross ML, Georgiadis MM. Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry. 52: 2955-66. PMID 23597102 DOI: 10.1021/Bi400179M  0.32
2013 McIlwain D, Fishel M, Wang L, Snider B, Zhang J, Kelley M, Jerde T. 991 APE1/REF-1 REGULATES SURVIVIN-MEDIATED DRUG RESISTANCE IN PROSTATE CANCER CELLS Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.573  0.317
2012 Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML. APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival. Plos One. 7: e47462. PMID 23094050 DOI: 10.1371/Journal.Pone.0047462  0.488
2012 Kelley MR, Georgiadis MM, Fishel ML. APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Current Molecular Pharmacology. 5: 36-53. PMID 22122463 DOI: 10.2174/1874467211205010036  0.493
2012 Kumar K, Jackson JL, Kelley MR, Ivan M, Sandsuky G. Abstract 1769: Significant in vivo activity of an APE1/Ref-1 redox inhibitor, E3330, alone and in combination with Bevacizumab in a glioblastoma mouse model analyzed by a whole slide digital imaging system and quantitative immunohistochemistry Cancer Research. 72: 1769-1769. DOI: 10.1158/1538-7445.Am2012-1769  0.411
2012 Kelley MR. Future Directions with DNA Repair Inhibitors: A Roadmap for Disruptive Approaches to Cancer Therapy Dna Repair in Cancer Therapy. 301-310. DOI: 10.1016/B978-0-12-384999-1.10014-9  0.443
2012 Kelley MR. Introduction and Overview of DNA Repair Targets: From Bench to Clinic Dna Repair in Cancer Therapy. 1-16. DOI: 10.1016/B978-0-12-384999-1.10001-0  0.344
2012 Kelley MR. DNA repair in cancer therapy Dna Repair in Cancer Therapy 0.338
2011 Kelley MR. DNA repair inhibitors: where do we go from here? Dna Repair. 10: 1183-5. PMID 21963404 DOI: 10.1016/J.Dnarep.2011.09.003  0.484
2011 Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G. Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function. Molecular Biology of the Cell. 22: 3887-901. PMID 21865600 DOI: 10.1091/Mbc.E11-05-0391  0.46
2011 Vasko MR, Guo C, Thompson EL, Kelley MR. The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation. Dna Repair. 10: 942-52. PMID 21741887 DOI: 10.1016/J.Dnarep.2011.06.004  0.442
2011 Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR. Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth. Molecular Cancer Therapeutics. 10: 1698-708. PMID 21700832 DOI: 10.1158/1535-7163.Mct-11-0107  0.408
2011 Onyango DO, Naguleswaran A, Delaplane S, Reed A, Kelley MR, Georgiadis MM, Sullivan WJ. Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii. Dna Repair. 10: 466-75. PMID 21353648 DOI: 10.1016/J.Dnarep.2011.01.011  0.513
2011 Rohrabaugh SL, Hangoc G, Kelley MR, Broxmeyer HE. Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro. Experimental Hematology. 39: 415-23. PMID 21216274 DOI: 10.1016/J.Exphem.2010.12.012  0.406
2011 Su D, Delaplane S, Luo M, Rempel DL, Vu B, Kelley MR, Gross ML, Georgiadis MM. Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme. Biochemistry. 50: 82-92. PMID 21117647 DOI: 10.1021/Bi101248S  0.343
2011 Jiang A, Gao H, Kelley MR, Qiao X. Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Research. 51: 93-100. PMID 20937296 DOI: 10.1016/J.Visres.2010.10.008  0.317
2011 Kelley MR, Luo M, Reed A, Su D, Delaplane S, Borch RF, Nyland RL, Gross ML, Georgiadis MM. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. Antioxidants & Redox Signaling. 14: 1387-401. PMID 20874257 DOI: 10.1089/Ars.2010.3410  0.43
2011 Fishel ML, Jiang Y, Luo M, Reed AM, He Y, Cardoso AM, Kelley MR. Abstract C173: APE1/Ref-1-STAT3 dual-targeting synergize to effectively inhibit pancreatic cancer cell survival. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C173  0.511
2010 Jiang Y, Zhou S, Sandusky GE, Kelley MR, Fishel ML. Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer Investigation. 28: 885-95. PMID 20919954 DOI: 10.3109/07357907.2010.512816  0.476
2010 Fishel ML, Colvin ES, Luo M, Kelley MR, Robertson KA. Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis. Experimental Hematology. 38: 1178-88. PMID 20826193 DOI: 10.1016/J.Exphem.2010.08.011  0.412
2010 Bapat A, Glass LS, Luo M, Fishel ML, Long EC, Georgiadis MM, Kelley MR. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. The Journal of Pharmacology and Experimental Therapeutics. 334: 988-98. PMID 20504914 DOI: 10.1124/Jpet.110.169128  0.797
2010 Glass LS, Bapat A, Kelley MR, Georgiadis MM, Long EC. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & Medicinal Chemistry Letters. 20: 1685-8. PMID 20144868 DOI: 10.1016/J.Bmcl.2010.01.033  0.792
2010 Nyland RL, Luo M, Kelley MR, Borch RF. Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). Journal of Medicinal Chemistry. 53: 1200-10. PMID 20067291 DOI: 10.1021/Jm9014857  0.443
2010 Luo M, He H, Kelley MR, Georgiadis MM. Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxidants & Redox Signaling. 12: 1247-69. PMID 19764832 DOI: 10.1089/Ars.2009.2698  0.531
2010 Bapat A, Glass LS, Luo M, Fishel ML, Reed A, Long EC, Georgiadis MM, Kelley MR. Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells Cellular and Molecular Biology. 70: 1963-1963. DOI: 10.1158/1538-7445.Am10-1963  0.797
2009 Robertson KA, Colvin ES, Kelley MR, Fishel ML. APX3330 inhibition of the redox function of ape-1/ref-1 (Ref-1) in promyelocytic leukemia cells enhances retinoic acid (ATRA) induced myeloid differentiation and limits cell proliferation as an approach to the prevention of the retinoic acid syndrome (RAS). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e14613. PMID 27964118 DOI: 10.1200/Jco.2009.27.15_Suppl.E14613  0.385
2009 Jiang Y, Guo C, Fishel ML, Wang ZY, Vasko MR, Kelley MR. Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. Dna Repair. 8: 1273-82. PMID 19726241 DOI: 10.1016/J.Dnarep.2009.08.003  0.55
2009 Reed AM, Fishel ML, Kelley MR. Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation. Future Oncology (London, England). 5: 713-26. PMID 19519210 DOI: 10.2217/Fon.09.31  0.513
2009 Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Molecular and Cellular Biology. 29: 1834-54. PMID 19188445 DOI: 10.1128/Mcb.01337-08  0.446
2009 Vascotto C, Cesaratto L, Zeef LA, Deganuto M, D'Ambrosio C, Scaloni A, Romanello M, Damante G, Taglialatela G, Delneri D, Kelley MR, Mitra S, Quadrifoglio F, Tell G. Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics. 9: 1058-74. PMID 19180539 DOI: 10.1002/Pmic.200800638  0.47
2009 Tell G, Quadrifoglio F, Tiribelli C, Kelley MR. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxidants & Redox Signaling. 11: 601-20. PMID 18976116 DOI: 10.1089/Ars.2008.2194  0.535
2009 Bapat A, Fishel ML, Kelley MR. Going ape as an approach to cancer therapeutics. Antioxidants & Redox Signaling. 11: 651-68. PMID 18715143 DOI: 10.1089/Ars.2008.2218  0.83
2008 Jiang Y, Guo C, Vasko MR, Kelley MR. Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons. Cancer Research. 68: 6425-34. PMID 18676868 DOI: 10.1158/0008-5472.Can-08-1173  0.482
2008 Rabik CA, Fishel ML, Holleran JL, Kasza K, Kelley MR, Egorin MJ, Dolan ME. Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress. The Journal of Pharmacology and Experimental Therapeutics. 327: 442-52. PMID 18664592 DOI: 10.1124/Jpet.108.141291  0.43
2008 Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL, Borch RF, Qiao X, Georgiadis MM, Kelley MR. Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxidants & Redox Signaling. 10: 1853-67. PMID 18627350 DOI: 10.1089/Ars.2008.2120  0.592
2008 Georgiadis MM, Luo M, Gaur RK, Delaplane S, Li X, Kelley MR. Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 643: 54-63. PMID 18579163 DOI: 10.1016/J.Mrfmmm.2008.04.008  0.347
2008 Kelley MR, Fishel ML. DNA repair proteins as molecular targets for cancer therapeutics. Anti-Cancer Agents in Medicinal Chemistry. 8: 417-25. PMID 18473726 DOI: 10.2174/187152008784220294  0.524
2008 Fishel ML, He Y, Reed AM, Chin-Sinex H, Hutchins GD, Mendonca MS, Kelley MR. Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth. Dna Repair. 7: 177-86. PMID 17974506 DOI: 10.1016/J.Dnarep.2007.09.008  0.523
2007 Hahn NM, Kelley MR, Klaunig JE, Koch MO, Li L, Sweeney CJ. Constitutional polymorphisms of prostate cancer: prognostic and diagnostic implications. Future Oncology (London, England). 3: 665-82. PMID 18041919 DOI: 10.2217/14796694.3.6.665  0.315
2007 Harrison JF, Rinne ML, Kelley MR, Druzhyna NM, Wilson GL, Ledoux SP. Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents. Glia. 55: 1416-25. PMID 17674369 DOI: 10.1002/Glia.20556  0.676
2007 Fishel ML, Kelley MR. The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Molecular Aspects of Medicine. 28: 375-95. PMID 17560642 DOI: 10.1016/J.Mam.2007.04.005  0.595
2007 Ho R, Rachek LI, Xu Y, Kelley MR, LeDoux SP, Wilson GL. Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress Journal of Neurochemistry. 102: 13-24. PMID 17506861 DOI: 10.1111/J.1471-4159.2007.04490.X  0.4
2007 Deganuto M, Pittis MG, Pines A, Dominissini S, Kelley MR, Garcia R, Quadrifoglio F, Bembi B, Tell G. Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress. Journal of Cellular Physiology. 212: 223-35. PMID 17443679 DOI: 10.1002/Jcp.21023  0.347
2007 Fishel ML, He Y, Smith ML, Kelley MR. Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 260-7. PMID 17200364 DOI: 10.1158/1078-0432.Ccr-06-1920  0.536
2007 Zou GM, Luo MH, Reed A, Kelley MR, Yoder MC. Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood. 109: 1917-22. PMID 17053053 DOI: 10.1182/Blood-2006-08-044172  0.472
2007 Fishel ML, Vasko MR, Kelley MR. DNA repair in neurons: so if they don't divide what's to repair? Mutation Research. 614: 24-36. PMID 16879837 DOI: 10.1016/J.Mrfmmm.2006.06.007  0.522
2007 Reed AM, Fishel ML, Kelley MR, Abonour R. Potentiation of Melphalan-Induced Cytotoxicity through Targeting of the Base Excision Repair Pathway in Multiple Myeloma. Blood. 110: 4799-4799. DOI: 10.1182/Blood.V110.11.4799.4799  0.526
2007 Robertson KA, Colvin ES, Kelley MR. Inhibition of the Redox Function of Ape-1/ref-1 in Myeloid Leukemia Cells Results in Enhanced Sensitivity to Retinoic Acid Induced Differentiation and Apoptosis. Blood. 110: 4217-4217. DOI: 10.1182/BLOOD.V110.11.4217.4217  0.322
2006 Wang D, Zhong ZY, Zhang QH, Li ZP, Kelley MR. [Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]. Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology. 35: 352-6. PMID 16834910 DOI: 10.3760/J.Issn:0529-5807.2006.06.008  0.538
2006 Ropolo M, Geroldi A, Degan P, Andreotti V, Zupo S, Poggi A, Reed A, Kelley MR, Frosina G. Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein. International Journal of Cancer. Journal International Du Cancer. 118: 1628-34. PMID 16217765 DOI: 10.1002/Ijc.21554  0.517
2006 Vasko MR, Guo C, Jiang YL, Kelley MR. 5 Enhancing the Expression of the Dna Repair/Redox Enzyme, Ape1/Ref-1, Reduces Neurotoxicity Induced by Ionizing Radiation: Implications for Decreasing Pediatric Neurocognitive Dysfunction. Pediatric Research. 60: 491-491. DOI: 10.1203/00006450-200610000-00027  0.324
2006 Robertson KA, Colvin ES, Luo M, Reed A, Kelley MR. Ape-1/ref-1 Mediated Redox Regulation of Retinoic Acid Receptor Transcription Function in Myeloid Leukemia Cell Differentiation and Apoptosis. Blood. 108: 1924-1924. DOI: 10.1182/Blood.V108.11.1924.1924  0.421
2005 Pines A, Perrone L, Bivi N, Romanello M, Damante G, Gulisano M, Kelley MR, Quadrifoglio F, Tell G. Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. Nucleic Acids Research. 33: 4379-94. PMID 16077024 DOI: 10.1093/Nar/Gki751  0.452
2005 Rinne ML, He Y, Pachkowski BF, Nakamura J, Kelley MR. N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts. Nucleic Acids Research. 33: 2859-67. PMID 15905475 DOI: 10.1093/Nar/Gki601  0.678
2005 Cai S, Xu Y, Cooper RJ, Ferkowicz MJ, Hartwell JR, Pollok KE, Kelley MR. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer Research. 65: 3319-27. PMID 15833865 DOI: 10.1158/0008-5472.Can-04-3335  0.529
2005 Pines A, Bivi N, Romanello M, Damante G, Kelley MR, Adamson ED, D'Andrea P, Quadrifoglio F, Moro L, Tell G. Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop. Free Radical Research. 39: 269-81. PMID 15788231 DOI: 10.1080/10715760400028423  0.516
2005 Tell G, Damante G, Caldwell D, Kelley MR. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxidants & Redox Signaling. 7: 367-84. PMID 15706084 DOI: 10.1089/Ars.2005.7.367  0.465
2005 Vasko MR, Guo C, Kelley MR. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. Dna Repair. 4: 367-79. PMID 15661660 DOI: 10.1016/J.Dnarep.2004.11.006  0.351
2005 Park SJ, Armstrong S, Kim CH, Yu M, Robertson K, Kelley MR, Lee SH. Lack of EGF receptor contributes to drug sensitivity of human germline cells British Journal of Cancer. 92: 334-341. PMID 15655552 DOI: 10.1038/Sj.Bjc.6602315  0.413
2005 Guo Y, Einhorn L, Kelley M, Hirota K, Yodoi J, Reinbold R, Scholer H, Ramsey H, Hromas R. Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin. Stem Cells (Dayton, Ohio). 22: 259-64. PMID 15153603 DOI: 10.1634/Stemcells.22-3-259  0.434
2004 Kremer TM, Rinne ML, Xu Y, Chen XM, Kelley MR. Protection of pulmonary epithelial cells from oxidative stress by hMYH adenine glycosylase. Respiratory Research. 5: 16. PMID 15450125 DOI: 10.1186/1465-9921-5-16  0.654
2004 Luo M, Kelley MR. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Research. 24: 2127-34. PMID 15330152  0.494
2004 Rinne M, Caldwell D, Kelley MR. Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Molecular Cancer Therapeutics. 3: 955-67. PMID 15299078  0.627
2004 Wang D, Luo M, Kelley MR. Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Molecular Cancer Therapeutics. 3: 679-86. PMID 15210853  0.336
2004 Kelley MR, Tompkinson AE, Williams KJ, Drinkwater NR, Fung VA. Frontiers of mutagenesis and DNA repair: a workshop. Cancer Research. 64: 3357-60. PMID 15126381 DOI: 10.1158/0008-5472.Can-04-0373  0.473
2004 Rinne M, Caldwell D, He Y, Kelley MR. 282. Transient Adenoviral Methylpurine DNA Glycosylase Overexpression Imparts Chemotherapeutic Sensitivity to Human Breast Cancer Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.220  0.667
2003 Bogliolo M, Cappelli E, D'Osualdo A, Rossi O, Barbieri O, Kelley MR, Frosina G. Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Anticancer Research. 23: 3727-34. PMID 14666670  0.43
2003 Freitas S, Moore DH, Michael H, Kelley MR. Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4689-94. PMID 14581338  0.418
2003 Cappelli E, D'Osualdo A, Bogliolo M, Kelley MR, Frosina G. Drosophila S3 ribosomal protein accelerates repair of 8-oxoguanine performed by human and mouse cell extracts. Environmental and Molecular Mutagenesis. 42: 50-8. PMID 12874813 DOI: 10.1002/Em.10166  0.458
2003 Roth TJ, Xu Y, Luo M, Kelley MR. Human-yeast chimeric repair protein protects mammalian cells against alkylating agents: enhancement of MGMT protection. Cancer Gene Therapy. 10: 603-10. PMID 12872142 DOI: 10.1038/Sj.Cgt.7700605  0.539
2003 Druzhyna NM, Hollensworth SB, Kelley MR, Wilson GL, Ledoux SP. Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress. Glia. 42: 370-8. PMID 12730957 DOI: 10.1002/Glia.10230  0.448
2003 Cappelli E, D'Osualdo A, Bogliolo M, Xu Y, Kelley MR, Frosina G. Repair of 8 oxoguanine in mammalian cells expressing the Drosophila S3 ribosomal/repair protein. Teratogenesis, Carcinogenesis, and Mutagenesis. 113-21. PMID 12616602 DOI: 10.1002/Tcm.10067  0.451
2003 Fishel ML, Seo YR, Smith ML, Kelley MR. Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. Cancer Research. 63: 608-15. PMID 12566303  0.446
2003 Kelley MR, Kow YW, Wilson DM. Disparity between DNA base excision repair in yeast and mammals: translational implications. Cancer Research. 63: 549-54. PMID 12566294  0.466
2003 Ladd PD, Wilson DM, Kelley MR, Skalnik DG. Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity. Dna Repair. 2: 187-98. PMID 12531389 DOI: 10.1016/S1568-7864(02)00195-7  0.372
2002 Bogliolo M, Cappelli E, D'Osualdo A, Rossi O, Barbieri O, Kelley MR, Frosina G. Effect of S. cerevisiae APN1 protein on mammalian DNA base excision repair. Anticancer Research. 22: 2797-804. PMID 12529999  0.43
2002 Seo YR, Kelley MR, Smith ML. Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 14548-53. PMID 12357032 DOI: 10.1073/Pnas.212319799  0.466
2002 Rachek LI, Grishko VI, Musiyenko SI, Kelley MR, LeDoux SP, Wilson GL. Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria. The Journal of Biological Chemistry. 277: 44932-7. PMID 12244119 DOI: 10.1074/Jbc.M208770200  0.508
2002 Wu M, He YH, Kobune M, Xu Y, Kelley MR, Martin WJ. Protection of human lung cells against hyperoxia using the DNA base excision repair genes hOgg1 and Fpg. American Journal of Respiratory and Critical Care Medicine. 166: 192-9. PMID 12119232 DOI: 10.1164/Rccm.200112-130Oc  0.511
2002 Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN. Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L205-10. PMID 12060578 DOI: 10.1152/Ajplung.00443.2001  0.421
2002 Dobson AW, Kelley MR, Wilson GL, LeDoux SP. Targeting DNA repair proteins to mitochondria. Methods in Molecular Biology (Clifton, N.J.). 197: 351-62. PMID 12013809 DOI: 10.1385/1-59259-284-8:351  0.467
2002 Seo YR, Fishel ML, Amundson S, Kelley MR, Smith ML. Implication of p53 in base excision DNA repair: in vivo evidence. Oncogene. 21: 731-7. PMID 11850801 DOI: 10.1038/Sj.Onc.1205129  0.502
2002 Tell G, Pines A, Paron I, D'Elia A, Bisca A, Kelley MR, Manzini G, Damante G. Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain. The Journal of Biological Chemistry. 277: 14564-74. PMID 11834746 DOI: 10.1074/Jbc.M200582200  0.406
2002 Puglisi F, Barbone F, Tell G, Aprile G, Pertoldi B, Raiti C, Kelley MR, Damante G, Sobrero A, Beltrami CA, Di Loreto C. Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas. Oncology Reports. 9: 11-7. PMID 11748448 DOI: 10.3892/Or.9.1.11  0.319
2002 He YH, Xu Y, Kobune M, Wu M, Kelley MR, Martin WJ. Escherichia coli FPG and human OGG1 reduce DNA damage and cytotoxicity by BCNU in human lung cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L50-5. PMID 11741815 DOI: 10.1152/Ajplung.00316.2001  0.419
2001 Thomson B, Tritt R, Davis M, Kelley MR. Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas Journal of Pediatric Hematology/Oncology. 23: 234-239. PMID 11846302 DOI: 10.1097/00043426-200105000-00011  0.424
2001 He YH, Wu M, Kobune M, Xu Y, Kelley MR, Martin WJ. Expression of yeast apurinic/apyrimidinic endonuclease (APN1) protects lung epithelial cells from bleomycin toxicity. American Journal of Respiratory Cell and Molecular Biology. 25: 692-8. PMID 11726394 DOI: 10.1165/Ajrcmb.25.6.4550  0.389
2001 Schindl M, Oberhuber G, Pichlbauer EG, Obermair A, Birner P, Kelley MR. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance International Journal of Oncology. 19: 799-802. PMID 11562758 DOI: 10.3892/Ijo.19.4.799  0.384
2001 Kelley MR, Parsons SH. Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1 Antioxidants and Redox Signaling. 3: 671-683. PMID 11554453 DOI: 10.1089/15230860152543014  0.53
2001 Hsieh MM, Hegde V, Kelley MR, Deutsch WA. Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation Nucleic Acids Research. 29: 3116-3122. PMID 11452037 DOI: 10.1093/Nar/29.14.3116  0.494
2001 Kobune M, Xu Y, Baum C, Kelley MR, Williams DA. Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N′,N″-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo Cancer Research. 61: 5116-5125. PMID 11431349  0.386
2001 Kreklau EL, Limp-Foster M, Liu N, Xu Y, Kelley MR, Erickson LC. A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase. Nucleic Acids Research. 29: 2558-66. PMID 11410664 DOI: 10.1093/Nar/29.12.2558  0.534
2001 Hegde V, Kelley MR, Xu Y, Mian IS, Deutsch WA. Conversion of the Bifunctional 8-Oxoguanine/β-δ Apurinic/Apyrimidinic DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β-Elimination Catalyst through a Single Amino Acid Change Journal of Biological Chemistry. 276: 27591-27596. PMID 11353770 DOI: 10.1074/jbc.M101213200  0.348
2001 Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, Koch M. Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer Clinical Cancer Research. 7: 824-830. PMID 11309329  0.313
2001 Robertson KA, Bullock HA, Xu Y, Tritt R, Zimmerman E, Ulbright TM, Foster RS, Einhorn LH, Kelley MR. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Research. 61: 2220-5. PMID 11280790  0.477
2001 Wu M, Kelley MR, Hansen WK, Martin WJ. Reduction of BCNU toxicity to lung cells by high-level expression of O(6)-methylguanine-DNA methyltransferase. American Journal of Physiology. Lung Cellular and Molecular Physiology. 280: L755-61. PMID 11238017 DOI: 10.1152/Ajplung.2001.280.4.L755  0.458
2001 Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G, Bandiera A, Kelley MR, Di Loreto C, Damante G. Mitochondrial localization of APE/Ref-1 in thyroid cells Mutation Research - Dna Repair. 485: 143-152. PMID 11182545 DOI: 10.1016/S0921-8777(00)00068-9  0.506
2001 Kelley MR, Tritt R, Xu Y, New S, Freie B, Clapp DW, Deutsch WA. The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents Mutation Research - Dna Repair. 485: 107-119. PMID 11182542 DOI: 10.1016/S0921-8777(00)00067-7  0.535
2001 Xu Y, Hansen WK, Rosenquist TA, Williams DA, Limp-Foster M, Kelley MR. Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications. The Journal of Pharmacology and Experimental Therapeutics. 296: 825-31. PMID 11181913  0.335
2000 Evans AR, Limp-Foster M, Kelley MR. Going APE over ref-1 Mutation Research - Dna Repair. 461: 83-108. PMID 11018583 DOI: 10.1016/S0921-8777(00)00046-X  0.751
2000 Hansen WK, Kelley MR. Review of mammalian DNA repair and translational implications. The Journal of Pharmacology and Experimental Therapeutics. 295: 1-9. PMID 10991953  0.42
2000 Dobson AW, Xu Y, Kelley MR, LeDoux SP, Wilson GL. Enhanced mitochondrial DNA repair and cellular survival after oxidative stress by targeting the human 8-oxoguanine glycosylase repair enzyme to mitochondria. The Journal of Biological Chemistry. 275: 37518-23. PMID 10982789 DOI: 10.1074/Jbc.M000831200  0.466
2000 Tell G, Pellizzari L, Pucillo C, Puglisi F, Cesselli D, Kelley MR, Di Loreto C, Damante G. TSH controls Ref-1 nuclear translocation in thyroid cells Journal of Molecular Endocrinology. 24: 383-390. PMID 10828831 DOI: 10.1677/Jme.0.0240383  0.406
2000 Kelley MR, Xu Y, Wilson DM, Deutsch WA. Genomic structure and characterization of the Drosophila S3 ribosomal/DNA repair gene and mutant alleles Dna and Cell Biology. 19: 149-156. PMID 10749167 DOI: 10.1089/104454900314537  0.386
2000 Limp-Foster M, Kelley MR. DNA repair and gene therapy: Implications for translational uses Environmental and Molecular Mutagenesis. 35: 71-81. PMID 10712740 DOI: 10.1002/(Sici)1098-2280(2000)35:2<71::Aid-Em1>3.0.Co;2-P  0.727
2000 Moore DH, Michael H, Tritt R, Parsons SH, Kelley MR. Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers Clinical Cancer Research. 6: 602-609. PMID 10690545  0.413
2000 Tell G, Zecca A, Pellizzari L, Spessotto P, Colombatti A, Kelley MR, Damante G, Pucillo C. An 'environment to nucleus' signaling system operates in B lymphocytes: Redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation Nucleic Acids Research. 28: 1099-1105. PMID 10666449 DOI: 10.1093/Nar/28.5.1099  0.487
1998 Robertson KA, Hill DP, Kelley MR, Tritt R, Crum B, Van Epps S, Srour E, Rice S, Hromas R. The myeloid zinc finger gene (MZF-1) delays retinoic acid-induced apoptosis and differentiation in myeloid leukemia cells Leukemia. 12: 690-698. PMID 9593266 DOI: 10.1038/Sj.Leu.2401005  0.333
1998 Hansen WK, Deutsch WA, Yacoub A, Xu Y, Williams DA, Kelley MR. Creation of a fully functional human chimeric DNA repair protein. Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins. The Journal of Biological Chemistry. 273: 756-62. PMID 9422728 DOI: 10.1074/Jbc.273.2.756  0.522
1997 Xu Y, Moore DH, Broshears J, Liu L, Wilson TM, Kelley MR. The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Research. 17: 3713-19. PMID 9427767  0.402
1997 Yacoub A, Kelley MR, Deutsch WA. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation Cancer Research. 57: 5457-5459. PMID 9407949  0.387
1997 Sandigursky M, Yacoub A, Kelley MR, Xu Y, Franklin WA, Deutsch WA. The yeast 8-oxoguanine DNA glycosylase (Ogg1) contains a DNA deoxyribophosphodiesterase (dRpase) activity Nucleic Acids Research. 25: 4557-4561. PMID 9358166 DOI: 10.1093/Nar/25.22.4557  0.503
1997 Clawson GA, Benedict CM, Kelley MR, Weisz J. Focal nuclear hepatocyte response to oxidative damage following low dose thioacetamide intoxication Carcinogenesis. 18: 1663-1668. PMID 9276646 DOI: 10.1093/Carcin/18.8.1663  0.44
1997 Sandigursky M, Yacoub A, Kelley MR, Deutsch WA, Franklin WA. The Drosophila ribosomal protein S3 contains a DNA deoxyribophosphodiesterase (dRpase) activity Journal of Biological Chemistry. 272: 17480-17484. PMID 9211893 DOI: 10.1074/jbc.272.28.17480  0.388
1997 Robertson KA, Hill DP, Xu Y, Liu L, Van Epps S, Hockenbery DM, Park JR, Wilson TM, Kelley MR. Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 8: 443-9. PMID 9101090  0.417
1997 Chun KT, Edenberg HJ, Kelley MR, Goebl MG. Rapid amplification of uncharacterized transposon-tagged DNA sequences from genomic DNA Yeast. 13: 233-240. PMID 9090052 DOI: 10.1002/(Sici)1097-0061(19970315)13:3<233::Aid-Yea88>3.0.Co;2-E  0.409
1997 Maze R, Kapur R, Kelley MR, Hansen WK, Oh SY, Williams DA. Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA. Journal of Immunology (Baltimore, Md. : 1950). 158: 1006-13. PMID 8993023  0.305
1996 Yacoub A, Kelley MR, Deutsch WA. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity Nucleic Acids Research. 24: 4298-4303. PMID 8932386 DOI: 10.1093/Nar/24.21.4298  0.486
1996 Yacoub A, Augeri L, Kelley MR, Doetsch PW, Deutsch WA. A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities Embo Journal. 15: 2306-2312. PMID 8641296  0.437
1996 Wilson TM, Rivkees SA, Deutsch WA, Kelley MR. Differential expression of the apurinic / apyrimidinic endonuclease (APE/ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutation Research. 362: 237-48. PMID 8637502 DOI: 10.1016/0921-8777(95)00053-4  0.423
1996 Maze R, Carney JP, Kelley MR, Glassner BJ, Williams DA, Samson L. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent Proceedings of the National Academy of Sciences of the United States of America. 93: 206-210. PMID 8552605 DOI: 10.1073/Pnas.93.1.206  0.423
1996 Yacoub A, Augeri L, Kelley MR, Doetsch PW, Deutsch WA. A Drosophila ribosomal protein contains 8-oxoguanine and abasic site DNA repair activities. The Embo Journal. 15: 2306-2312. DOI: 10.1002/J.1460-2075.1996.Tb00584.X  0.435
1995 Duguid JR, Eble JN, Wilson TM, Kelley MR. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Research. 55: 6097-102. PMID 8521399  0.325
1995 Wilson TM, Yu-Lee LY, Kelley MR. Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression. Molecular Endocrinology (Baltimore, Md.). 9: 44-53. PMID 7760850 DOI: 10.1210/Mend.9.1.7760850  0.351
1995 Huq I, Wilson TM, Kelley MR, Deutsch WA. Expression in Escherichia coli of a rat cDNA encoding an apurinic/apyrimidinic endonuclease. Mutation Research. 337: 191-9. PMID 7491122 DOI: 10.1016/0921-8777(95)00024-E  0.47
1994 Pieper RO, Morgan SE, Kelley MR. The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity. Carcinogenesis. 15: 1895-902. PMID 7923583 DOI: 10.1093/Carcin/15.9.1895  0.444
1994 Wilson DM, Tentler JJ, Carney JP, Wilson TM, Kelley MR. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. Alcoholism, Clinical and Experimental Research. 18: 1267-71. PMID 7847618 DOI: 10.1111/J.1530-0277.1994.Tb00117.X  0.359
1994 Rivkees SA, Kelley MR. Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei Brain Research. 666: 137-142. PMID 7534193 DOI: 10.1016/0006-8993(94)90296-8  0.487
1994 Wilson DM, Deutsch WA, Kelley MR. Drosophila ribosomal protein S3 contains an activity that cleaves DNA at apurinic/apyrimidinic sites. Journal of Biological Chemistry. 269: 25359-25364. DOI: 10.1016/s0021-9258(18)47256-0  0.331
1993 Wilson DM, Deutsch WA, Kelley MR. Cloning of the Drosophila ribosomal protein S3: another multifunctional ribosomal protein with AP endonuclease DNA repair activity. Nucleic Acids Research. 21: 2516. PMID 7685082 DOI: 10.1093/NAR/21.10.2516  0.334
1992 Grabowski DT, Pieper RO, Futscher BW, Deutsch WA, Erickson LC, Kelley MR. Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. Carcinogenesis. 13: 259-63. PMID 1740017 DOI: 10.1093/Carcin/13.2.259  0.437
1991 Grabowski DT, Deutsch WA, Derda D, Kelley MR. Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein PO Nucleic Acids Research. 19: 4297-4297. PMID 1870984 DOI: 10.1093/Nar/19.15.4297  0.429
1991 Guzder SN, Kelley MR, Deutsch WA. Drosophila methyltransferase activity and the repair of alkylated DNA. Mutation Research. 255: 143-53. PMID 1717843 DOI: 10.1016/0921-8777(91)90048-T  0.316
1989 Kelley MR, Venugopal S, Harless J, Deutsch WA. Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease. Molecular and Cellular Biology. 9: 965-973. DOI: 10.1128/MCB.9.3.965  0.301
1986 Russel M, Kidd S, Kelley MR. An improved filamentous helper phage for generating single-stranded plasmid DNA Gene. 45: 333-338. PMID 3026919 DOI: 10.1016/0378-1119(86)90032-6  0.336
1983 Kelley MR, Lee WR. Mutagenesis in Oocytes of DROSOPHILA MELANOGASTER. I. Scheduled Synthesis of Nuclear and Mitochondrial DNA and Unscheduled DNA Synthesis. Genetics. 104: 279-99. PMID 17246137  0.393
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