| Year |
Citation |
Score |
| 2023 |
Geada I, Roldão A, Betenbaugh MJ, Alves PM. Advanced cell technologies: Making protein, cell, and gene therapies a reality. Biotechnology and Bioengineering. PMID 37534587 DOI: 10.1002/bit.28521 |
0.304 |
|
| 2023 |
Sacco SA, McAtee Pereira AG, Trenary I, Smith KD, Betenbaugh MJ, Young JD. Overexpression of peroxisome proliferator-activated receptor γ co-activator-1⍺ (PGC-1⍺) in Chinese hamster ovary cells increases oxidative metabolism and IgG productivity. Metabolic Engineering. PMID 37473833 DOI: 10.1016/j.ymben.2023.07.005 |
0.325 |
|
| 2023 |
Dhara VG, Kumar S, DeVine L, Naik HM, Cole RN, More AJ, Lau EC, Betenbaugh MJ. Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese Hamster Ovary cell cultures. Biotechnology Journal. e2200243. PMID 36892270 DOI: 10.1002/biot.202200243 |
0.323 |
|
| 2023 |
Chen Y, Betenbaugh MJ. Reconstruction of reverse transsulfuration pathway enables cysteine biosynthesis and enhances resilience to oxidative stress in Chinese Hamster Ovary cells. Metabolic Engineering. PMID 36822463 DOI: 10.1016/j.ymben.2023.02.010 |
0.387 |
|
| 2022 |
Cordova LT, Dahodwala H, Elliott KS, Baik J, Odenewelder DC, Nmagu D, Skelton BA, Uy L, Klaubert SR, Synoground BF, Chitwood DG, Dhara VG, Naik HM, Morris CS, Yoon S, ... Betenbaugh M, et al. Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing. Biotechnology and Bioengineering. PMID 36411514 DOI: 10.1002/bit.28290 |
0.826 |
|
| 2022 |
Kumar S, Kumar A, Huhn S, DeVine L, Cole R, Du Z, Betenbaugh M. A Proteomics Approach to Decipher a Sticky CHO Situation. Biotechnology and Bioengineering. PMID 35470426 DOI: 10.1002/bit.28108 |
0.345 |
|
| 2022 |
Sacco SA, Tuckowski AM, Trenary I, Kraft L, Betenbaugh MJ, Young JD, Smith KD. Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells. Biotechnology and Bioengineering. PMID 35312045 DOI: 10.1002/bit.28084 |
0.366 |
|
| 2022 |
Demirhan D, Kumar A, Zhu J, Poulsen PC, Majewska NI, Sebastian Y, Chaerkady R, Yu W, Zhu W, Zhuang L, Shah P, Lekstrom K, Cole RN, Zhang H, Betenbaugh MJ, et al. Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines. Scientific Reports. 12: 3280. PMID 35228567 DOI: 10.1038/s41598-022-06886-1 |
0.348 |
|
| 2022 |
McFarland KS, Zhu J, Sinharoy P, Betenbaugh MJ, Handlogten MW. Engineering redox sensors into CHO cells enables near-real-time quantification of intracellular redox in bioprocesses. Biotechnology and Bioengineering. PMID 35182429 DOI: 10.1002/bit.28067 |
0.312 |
|
| 2021 |
Chen Y, Liu X, Anderson JY, Naik HM, Dhara VG, Chen X, Harris GA, Betenbaugh MJ. A genome-scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures. Biotechnology and Bioengineering. PMID 34811743 DOI: 10.1002/bit.27994 |
0.37 |
|
| 2021 |
Kirsch BJ, Bennun SV, Mendez A, Johnson AS, Wang H, Qiu H, Li N, Lawrence SM, Bak H, Betenbaugh MJ. Metabolic Analysis of the Asparagine and Glutamine Dynamics in an Industrial CHO Fed-Batch Process. Biotechnology and Bioengineering. PMID 34786689 DOI: 10.1002/bit.27993 |
0.584 |
|
| 2021 |
Yang G, Wang Q, Chen L, Betenbaugh MJ, Zhang H. Glycoproteomic Characterization of FUT8 Knock-Out CHO Cells Reveals Roles of FUT8 in the Glycosylation. Frontiers in Chemistry. 9: 755238. PMID 34778211 DOI: 10.3389/fchem.2021.755238 |
0.402 |
|
| 2021 |
Kuang B, Dhara VG, Hoang D, Jenkins J, Ladiwala P, Tan Y, Shaffer SA, Galbraith SC, Betenbaugh MJ, Yoon S. Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells. Metabolic Engineering Communications. 13: e00182. PMID 34522610 DOI: 10.1016/j.mec.2021.e00182 |
0.351 |
|
| 2021 |
Sinharoy P, McFarland KS, Majewska NI, Betenbaugh MJ, Handlogten MW. Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production. Current Opinion in Biotechnology. 71: 49-54. PMID 34243034 DOI: 10.1016/j.copbio.2021.06.017 |
0.308 |
|
| 2021 |
Sinharoy P, McFarland KS, Majewska NI, Betenbaugh MJ, Handlogten MW. Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production. Current Opinion in Biotechnology. 71: 49-54. PMID 34243034 DOI: 10.1016/j.copbio.2021.06.017 |
0.308 |
|
| 2020 |
Kumar S, Dhara VG, Orzolek LD, Hao H, More AJ, Lau EC, Betenbaugh MJ. Elucidating the impact of cottonseed hydrolysates on CHO cell culture performance through transcriptomic analysis. Applied Microbiology and Biotechnology. PMID 33201275 DOI: 10.1007/s00253-020-10972-7 |
0.386 |
|
| 2020 |
Heffner K, Hizal DB, Majewska NI, Kumar S, Dhara VG, Zhu J, Bowen M, Hatton D, Yerganian G, Yerganian A, O'Meally R, Cole R, Betenbaugh M. Expanded Chinese hamster organ and cell line proteomics profiling reveals tissue-specific functionalities. Scientific Reports. 10: 15841. PMID 32985598 DOI: 10.1038/s41598-020-72959-8 |
0.332 |
|
| 2020 |
Wang Q, Wang T, Yang S, Sha S, Wu WW, Chen Y, Paul JT, Shen RF, Cipollo JF, Betenbaugh MJ. Metabolic engineering challenges of extending N-glycan pathways in Chinese hamster ovary cells. Metabolic Engineering. PMID 32663509 DOI: 10.1016/J.Ymben.2020.06.007 |
0.431 |
|
| 2020 |
Jiang L, Li T, Jenkins J, Hu Y, Brueck CL, Pei H, Betenbaugh MJ. Evidence for a mutualistic relationship between the cyanobacteria Nostoc and fungi Aspergilli in different environments. Applied Microbiology and Biotechnology. PMID 32472175 DOI: 10.1007/S00253-020-10663-3 |
0.353 |
|
| 2020 |
Yang G, Höti N, Chen SY, Zhou Y, Wang Q, Betenbaugh M, Zhang H. One-Step Enrichment of Intact Glycopeptides From Glycoengineered Chinese Hamster Ovary Cells. Frontiers in Chemistry. 8: 240. PMID 32363175 DOI: 10.3389/Fchem.2020.00240 |
0.42 |
|
| 2020 |
Majewska NI, Tejada ML, Betenbaugh MJ, Agarwal N. Glycosylation of IgG and IgG-Like Recombinant Therapeutic Proteins: Why Is It Important and How Can We Control It? Annual Review of Chemical and Biomolecular Engineering. PMID 32176521 DOI: 10.1146/Annurev-Chembioeng-102419-010001 |
0.322 |
|
| 2020 |
Gutierrez JM, Feizi A, Li S, Kallehauge TB, Hefzi H, Grav LM, Ley D, Baycin Hizal D, Betenbaugh MJ, Voldborg B, Faustrup Kildegaard H, Min Lee G, Palsson BO, Nielsen J, Lewis NE. Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. Nature Communications. 11: 68. PMID 31896772 DOI: 10.1038/S41467-019-13867-Y |
0.804 |
|
| 2020 |
Inwood S, Abaandou L, Betenbaugh M, Shiloach J. Improved protein expression in HEK293 cells by over-expressing miR-22 and knocking-out its target gene, HIPK1 New Biotechnology. 54: 28-33. DOI: 10.1016/J.Nbt.2019.08.004 |
0.388 |
|
| 2019 |
Chung CY, Wang Q, Yang S, Chough S, Seo Y, Cipollo JF, Balthasar JP, Betenbaugh MJ. The Impact of Sialylation Linkage Type on the Pharmacokinetics of Recombinant Butyrylcholinesterases. Biotechnology and Bioengineering. PMID 31544955 DOI: 10.1002/Bit.27174 |
0.347 |
|
| 2019 |
Wang Q, Chen Y, Park J, Liu X, Hu Y, Wang T, McFarland K, Betenbaugh MJ. Design and Production of Bispecific Antibodies. Antibodies (Basel, Switzerland). 8. PMID 31544849 DOI: 10.3390/Antib8030043 |
0.368 |
|
| 2019 |
Wang Q, Yang G, Wang T, Yang W, Betenbaugh MJ, Zhang H. Characterization of intact glycopeptides reveals the impact of culture media on site-specific glycosylation of EPO-Fc fusion protein generated by CHO-GS cells. Biotechnology and Bioengineering. PMID 31062865 DOI: 10.1002/Bit.27009 |
0.377 |
|
| 2019 |
Li S, Cha SW, Hefner K, Hizal DB, Bowen MA, Chaerkady R, Cole RN, Tejwani V, Kaushik P, Henry M, Meleady P, Sharfstein ST, Betenbaugh MJ, Bafna V, Lewis NE. Proteogenomic annotation of the Chinese hamster reveals extensive novel translation events and endogenous retroviral elements. Journal of Proteome Research. PMID 31020842 DOI: 10.1021/Acs.Jproteome.8B00935 |
0.379 |
|
| 2018 |
Wang Q, Betenbaugh MJ. Metabolic engineering of CHO cells to prepare glycoproteins. Emerging Topics in Life Sciences. 2: 433-442. PMID 33525787 DOI: 10.1042/ETLS20180056 |
0.325 |
|
| 2018 |
Dhara VG, Naik HM, Majewska NI, Betenbaugh MJ. Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 32: 571-584. PMID 30499081 DOI: 10.1007/S40259-018-0319-9 |
0.506 |
|
| 2018 |
Yang G, Hu Y, Sun S, Ouyang C, Yang W, Wang Q, Betenbaugh MJ, Zhang H. Comprehensive Glycoproteomic Analysis of Chinese Hamster Ovary Cells. Analytical Chemistry. PMID 30457839 DOI: 10.1021/Acs.Analchem.8B03520 |
0.444 |
|
| 2018 |
Wang Q, Chung CY, Rosenberg JN, Yu G, Betenbaugh MJ. Application of the CRISPR/Cas9 Gene Editing Method for Modulating Antibody Fucosylation in CHO Cells. Methods in Molecular Biology (Clifton, N.J.). 1850: 237-257. PMID 30242691 DOI: 10.1007/978-1-4939-8730-6_16 |
0.44 |
|
| 2018 |
Inwood S, Betenbaugh MJ, Lal M, Shiloach J. Genome-Wide High-Throughput RNAi Screening for Identification of Genes Involved in Protein Production. Methods in Molecular Biology (Clifton, N.J.). 1850: 209-219. PMID 30242689 DOI: 10.1007/978-1-4939-8730-6_14 |
0.426 |
|
| 2018 |
Wang Q, Chung CY, Yang W, Yang G, Chough S, Chen Y, Yin B, Bhattacharya R, Hu Y, Saeui CT, Yarema KJ, Betenbaugh MJ, Zhang H. Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production. Biotechnology Journal. e1800186. PMID 30221828 DOI: 10.1002/Biot.201800186 |
0.403 |
|
| 2018 |
Inwood S, Xu H, Black MA, Betenbaugh MJ, Feldman S, Shiloach J. Continuous production process of retroviral vector for adoptive T- cell therapy. Biochemical Engineering Journal. 132: 145-151. PMID 29977134 DOI: 10.1016/J.Bej.2018.01.010 |
0.444 |
|
| 2018 |
Heffner KM, Wang Q, Hizal DB, Can Ö, Betenbaugh MJ. Glycoengineering of Mammalian Expression Systems on a Cellular Level. Advances in Biochemical Engineering/Biotechnology. PMID 29532110 DOI: 10.1007/10_2017_57 |
0.5 |
|
| 2018 |
Wang Q, Chung CY, Chough S, Betenbaugh MJ. Antibody Glycoengineering Strategies in Mammalian Cells. Biotechnology and Bioengineering. PMID 29457629 DOI: 10.1002/Bit.26567 |
0.335 |
|
| 2018 |
Yin B, Wang Q, Chung CY, Ren X, Bhattacharya R, Yarema KJ, Betenbaugh MJ. Butyrated ManNAc analog improves protein expression in Chinese hamster ovary cells. Biotechnology and Bioengineering. PMID 29427449 DOI: 10.1002/Bit.26560 |
0.525 |
|
| 2018 |
Inwood S, Betenbaugh MJ, Shiloach J. Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells. Genes. 9. PMID 29315258 DOI: 10.3390/Genes9010025 |
0.453 |
|
| 2018 |
Naik HM, Majewska NI, Betenbaugh MJ. Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture Current Opinion in Chemical Engineering. 22: 167-176. DOI: 10.1016/J.Coche.2018.10.002 |
0.37 |
|
| 2018 |
Park J, Inwood S, Kruthiventi S, Jenkins J, Shiloach J, Betenbaugh M. Progressing from transient to stable packaging cell lines for continuous production of lentiviral and gammaretroviral vectors Current Opinion in Chemical Engineering. 22: 128-137. DOI: 10.1016/J.Coche.2018.09.007 |
0.411 |
|
| 2018 |
Jenkins J, Park J, Petersen K, Shajihan K, Kruthiventi S, Betenbaugh M. Adoptive T cell therapy: engineering and biomanufacturing chimeric antigen receptor-T cell Current Opinion in Chemical Engineering. 22: 26-33. DOI: 10.1016/J.Coche.2018.08.006 |
0.354 |
|
| 2017 |
Wang Q, Chen CH, Chung CY, Priola J, Chu JH, Tang J, Ulmschneider MB, Betenbaugh MJ. Proline-rich chaperones are compared computationally and experimentally for their abilities to facilitate recombinant butyrylcholinesterase tetramerization in CHO cells. Biotechnology Journal. PMID 29024569 DOI: 10.1002/Biot.201700479 |
0.348 |
|
| 2017 |
Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J. Identifying HIPK1 as target of miR-22-3p enhancing recombinant protein production from HEK 293 cell by using microarray and HTP siRNA screen. Biotechnology Journal. PMID 28987030 DOI: 10.1002/Biot.201700342 |
0.424 |
|
| 2017 |
Zuniga C, Levering J, Antoniewicz MR, Guarnieri MT, Betenbaugh MJ, Zengler K. Predicting dynamic metabolic demands in the photosynthetic eukaryote Chlorella vulgaris. Plant Physiology. PMID 28951490 DOI: 10.1104/Pp.17.00605 |
0.306 |
|
| 2017 |
Chung CY, Wang Q, Yang S, Ponce SA, Kirsch BJ, Zhang H, Betenbaugh MJ. Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells. Biotechnology and Bioengineering. PMID 28926673 DOI: 10.1002/Bit.26375 |
0.411 |
|
| 2017 |
Vcelar S, Jadhav V, Melcher M, Auer N, Hrdina A, Sagmeister R, Heffner K, Puklowski A, Betenbaugh M, Wenger T, Leisch F, Baumann M, Borth N. Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting. Biotechnology and Bioengineering. PMID 28921524 DOI: 10.1002/Bit.26453 |
0.385 |
|
| 2017 |
Heffner KM, Hizal DB, Yerganian GS, Kumar A, Can Ö, O'Meally RN, Cole R, Chaerkady R, Wu H, Bowen MA, Betenbaugh MJ. Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison. Journal of Proteome Research. PMID 28876938 DOI: 10.1021/Acs.Jproteome.7B00382 |
0.479 |
|
| 2017 |
Wang Q, Yin B, Chung CY, Betenbaugh MJ. Glycoengineering of CHO Cells to Improve Product Quality. Methods in Molecular Biology (Clifton, N.J.). 1603: 25-44. PMID 28493121 DOI: 10.1007/978-1-4939-6972-2_2 |
0.455 |
|
| 2017 |
Krambeck FJ, Bennun SV, Andersen MR, Betenbaugh MJ. Model-based analysis of N-glycosylation in Chinese hamster ovary cells. Plos One. 12: e0175376. PMID 28486471 DOI: 10.1371/Journal.Pone.0175376 |
0.43 |
|
| 2017 |
Yin B, Wang Q, Chung CY, Bhattacharya R, Ren X, Tang J, Yarema KJ, Betenbaugh MJ. A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells. Biotechnology and Bioengineering. PMID 28295160 DOI: 10.1002/Bit.26291 |
0.411 |
|
| 2017 |
Kelly PS, Clarke C, Costello A, Monger C, Meiller J, Dhiman H, Borth N, Betenbaugh MJ, Clynes M, Barron N. Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells. Metabolic Engineering. PMID 28188893 DOI: 10.1016/J.Ymben.2017.02.001 |
0.441 |
|
| 2017 |
Templeton N, Smith KD, McAtee-Pereira AG, Dorai H, Betenbaugh MJ, Lang SE, Young JD. Application of (13)C flux analysis to identify high-productivity CHO metabolic phenotypes. Metabolic Engineering. PMID 28122259 DOI: 10.1016/J.Ymben.2017.01.008 |
0.433 |
|
| 2016 |
Zhang Y, Baycin Hizal D, Kumar A, Priola J, Bahri M, Heffner KM, Wang M, Han X, Bowen MA, Betenbaugh MJ. High-troughput Lipidomic and Transcriptomic Analysis to Compare SP2/0, CHO, and HEK-293 Mammalian Cell Lines. Analytical Chemistry. PMID 27991764 DOI: 10.1021/Acs.Analchem.6B02984 |
0.806 |
|
| 2016 |
Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, ... ... Betenbaugh MJ, et al. A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. Cell Systems. 3: 434-443.e8. PMID 27883890 DOI: 10.1016/J.Cels.2016.10.020 |
0.483 |
|
| 2016 |
Bennun SV, Hizal DB, Heffner K, Can O, Zhang H, Betenbaugh MJ. Systems Glycobiology: Integrating glycogenomics, glycoproteomics, glycomics and other 'omics data sets to characterize cellular glycosylation processes. Journal of Molecular Biology. PMID 27423401 DOI: 10.1016/J.Jmb.2016.07.005 |
0.374 |
|
| 2016 |
Priola JJ, Calzadilla N, Baumann M, Borth N, Tate CG, Betenbaugh MJ. High-throughput screening and selection of mammalian cells for enhanced protein production. Biotechnology Journal. PMID 27276699 DOI: 10.1002/Biot.201500579 |
0.434 |
|
| 2016 |
Xiao S, Chen YC, Buehler E, Mandal S, Mandal A, Betenbaugh M, Park MH, Martin S, Shiloach J. Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells. Biotechnology and Bioengineering. PMID 27215166 DOI: 10.1002/Bit.26017 |
0.456 |
|
| 2016 |
Williams A, Hayashi T, Wolozny D, Yin B, Su TC, Betenbaugh MJ, Su TP. The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. Journal of Bioenergetics and Biomembranes. PMID 27155879 DOI: 10.1007/S10863-016-9664-X |
0.318 |
|
| 2016 |
Chu C, Bottaro DP, Betenbaugh MJ, Shiloach J. Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells. Plos One. 11: e0148075. PMID 26848584 DOI: 10.1371/Journal.Pone.0148075 |
0.645 |
|
| 2016 |
Gramlich PA, Westbroek W, Feldman RA, Awad O, Mello N, Remington MP, Sun Y, Zhang W, Sidransky E, Betenbaugh MJ, Fishman PS. A Peptide-Linked Recombinant Glucocerebrosidase for Targeted Neuronal Delivery: Design, Production, and Assessment. Journal of Biotechnology. PMID 26795355 DOI: 10.1016/J.Jbiotec.2016.01.015 |
0.334 |
|
| 2016 |
Bohutskyi P, Kligerman DC, Byers N, Nasr LK, Cua C, Chow S, Su C, Tang Y, Betenbaugh MJ, Bouwer EJ. Effects of inoculum size, light intensity, and dose of anaerobic digestion centrate on growth and productivity of Chlorella and Scenedesmus microalgae and their poly-culture in primary and secondary wastewater Algal Research. 19: 278-290. DOI: 10.1016/J.Algal.2016.09.010 |
0.303 |
|
| 2015 |
Yang S, Wang M, Chen L, Yin B, Song G, Turko IV, Phinney KW, Betenbaugh MJ, Zhang H, Li S. QUANTITY: An Isobaric Tag for Quantitative Glycomics. Scientific Reports. 5: 17585. PMID 26616285 DOI: 10.1038/Srep17585 |
0.351 |
|
| 2015 |
Kumar A, Baycin-Hizal D, Zhang Y, Bowen MA, Betenbaugh MJ. Cellular traffic cops: the interplay between lipids and proteins regulates vesicular formation, trafficking, and signaling in mammalian cells. Current Opinion in Biotechnology. 36: 215-221. PMID 26540512 DOI: 10.1016/J.Copbio.2015.09.006 |
0.321 |
|
| 2015 |
Yu G, Rosenberg JN, Betenbaugh MJ, Oyler GA. Pac-Man for biotechnology: co-opting degrons for targeted protein degradation to control and alter cell function. Current Opinion in Biotechnology. 36: 199-204. PMID 26435348 DOI: 10.1016/J.Copbio.2015.08.023 |
0.398 |
|
| 2015 |
Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ. Elucidation of the CHO Super-Ome (CHO-SO) by ProteoInfomatics. Journal of Proteome Research. PMID 26418914 DOI: 10.1021/Acs.Jproteome.5B00588 |
0.443 |
|
| 2015 |
Yin B, Gao Y, Chung CY, Yang S, Blake E, Stuczynski MC, Tang J, Kildegaard HF, Andersen MR, Zhang H, Betenbaugh MJ. Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation. Biotechnology and Bioengineering. PMID 26154505 DOI: 10.1002/Bit.25650 |
0.336 |
|
| 2015 |
Wang Q, Stuczynski M, Gao Y, Betenbaugh MJ. Strategies for Engineering Protein N-Glycosylation Pathways in Mammalian Cells. Methods in Molecular Biology (Clifton, N.J.). 1321: 287-305. PMID 26082230 DOI: 10.1007/978-1-4939-2760-9_20 |
0.477 |
|
| 2015 |
Viswanathan K, Narang S, Betenbaugh MJ. Engineering Sialic Acid Synthesis Ability in Insect Cells. Methods in Molecular Biology (Clifton, N.J.). 1321: 171-8. PMID 26082222 DOI: 10.1007/978-1-4939-2760-9_12 |
0.674 |
|
| 2015 |
Chung CY, Yin B, Wang Q, Chuang KY, Chu JH, Betenbaugh MJ. Assessment of the coordinated role of ST3GAL3, ST3GAL4 and ST3GAL6 on the α2,3 sialylation linkage of mammalian glycoproteins. Biochemical and Biophysical Research Communications. 463: 211-5. PMID 25998389 DOI: 10.1016/J.Bbrc.2015.05.023 |
0.436 |
|
| 2015 |
Bohutskyi P, Liu K, Nasr LK, Byers N, Rosenberg JN, Oyler GA, Betenbaugh MJ, Bouwer EJ. Bioprospecting of microalgae for integrated biomass production and phytoremediation of unsterilized wastewater and anaerobic digestion centrate. Applied Microbiology and Biotechnology. 99: 6139-54. PMID 25947241 DOI: 10.1007/S00253-015-6603-4 |
0.304 |
|
| 2015 |
Fan Y, Del Val IJ, Müller C, Lund AM, Sen JW, Rasmussen SK, Kontoravdi C, Baycin-Hizal D, Betenbaugh MJ, Weilguny D, Andersen MR. A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture. Biotechnology and Bioengineering. PMID 25899530 DOI: 10.1002/Bit.25620 |
0.446 |
|
| 2015 |
Kaas CS, Kristensen C, Betenbaugh MJ, Andersen MR. Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy. Bmc Genomics. 16: 160. PMID 25887056 DOI: 10.1186/S12864-015-1391-X |
0.405 |
|
| 2015 |
Xiao S, Chen YC, Betenbaugh MJ, Martin SE, Shiloach J. MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK 293 cells. Biotechnology and Bioengineering. 112: 1632-43. PMID 25676429 DOI: 10.1002/Bit.25567 |
0.366 |
|
| 2015 |
Gopalakrishnan S, Baker J, Kristoffersen L, Betenbaugh MJ. Redistribution of metabolic fluxes in Chlorella protothecoides by variation of media nitrogen concentration Metabolic Engineering Communications. 2: 124-131. DOI: 10.1016/J.Meteno.2015.09.004 |
0.303 |
|
| 2015 |
Apostolidis PA, Tseng A, Koziol ME, Betenbaugh MJ, Chiang B. Investigation of low viability in sparged bioreactor CHO cell cultures points to variability in the Pluronic F-68 shear protecting component of cell culture media Biochemical Engineering Journal. 98: 10-17. DOI: 10.1016/J.Bej.2015.01.013 |
0.443 |
|
| 2014 |
Wan M, Jin X, Xia J, Rosenberg JN, Yu G, Nie Z, Oyler GA, Betenbaugh MJ. The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Applied Microbiology and Biotechnology. 98: 9473-81. PMID 25248441 DOI: 10.1007/S00253-014-6088-6 |
0.337 |
|
| 2014 |
Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD. The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism. Metabolic Engineering. 25: 92-102. PMID 25014175 DOI: 10.1016/J.Ymben.2014.06.010 |
0.479 |
|
| 2014 |
Heffner KM, Hizal DB, Kumar A, Shiloach J, Zhu J, Bowen MA, Betenbaugh MJ. Exploiting the proteomics revolution in biotechnology: from disease and antibody targets to optimizing bioprocess development. Current Opinion in Biotechnology. 30: 80-6. PMID 24997444 DOI: 10.1016/J.Copbio.2014.06.006 |
0.408 |
|
| 2014 |
Ronda C, Pedersen LE, Hansen HG, Kallehauge TB, Betenbaugh MJ, Nielsen AT, Kildegaard HF. Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool. Biotechnology and Bioengineering. 111: 1604-16. PMID 24827782 DOI: 10.1002/Bit.25233 |
0.377 |
|
| 2014 |
Baycin Hizal D, Wolozny D, Colao J, Jacobson E, Tian Y, Krag SS, Betenbaugh MJ, Zhang H. Glycoproteomic and glycomic databases. Clinical Proteomics. 11: 15. PMID 24725457 DOI: 10.1186/1559-0275-11-15 |
0.769 |
|
| 2014 |
Xiao S, Shiloach J, Betenbaugh MJ. Engineering cells to improve protein expression. Current Opinion in Structural Biology. 26: 32-8. PMID 24704806 DOI: 10.1016/J.Sbi.2014.03.005 |
0.483 |
|
| 2014 |
Zustiak MP, Jose L, Xie Y, Zhu J, Betenbaugh MJ. Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL. Biotechnology Journal. 9: 1164-74. PMID 24604826 DOI: 10.1002/Biot.201300468 |
0.841 |
|
| 2014 |
Lewis A, Hayashi T, Su TP, Betenbaugh MJ. Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival. Journal of Bioenergetics and Biomembranes. 46: 1-15. PMID 24078116 DOI: 10.1007/S10863-013-9527-7 |
0.306 |
|
| 2014 |
Kumar A, Heffner KM, Shiloach J, Betenbaugh MJ, Baycin-Hizal D. Harnessing Chinese hamster ovary cell proteomics for biopharmaceutical processing Pharmaceutical Bioprocessing. 2: 421-435. DOI: 10.4155/Pbp.14.49 |
0.516 |
|
| 2013 |
Jadhav V, Hackl M, Druz A, Shridhar S, Chung CY, Heffner KM, Kreil DP, Betenbaugh M, Shiloach J, Barron N, Grillari J, Borth N. CHO microRNA engineering is growing up: recent successes and future challenges. Biotechnology Advances. 31: 1501-13. PMID 23916872 DOI: 10.1016/J.Biotechadv.2013.07.007 |
0.74 |
|
| 2013 |
Lewis NE, Liu X, Li Y, Nagarajan H, Yerganian G, O'Brien E, Bordbar A, Roth AM, Rosenbloom J, Bian C, Xie M, Chen W, Li N, Baycin-Hizal D, Latif H, ... ... Betenbaugh MJ, et al. Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nature Biotechnology. 31: 759-65. PMID 23873082 DOI: 10.1038/Nbt.2624 |
0.435 |
|
| 2013 |
Gramlich PA, Remington MP, Amin J, Betenbaugh MJ, Fishman PS. Tat-tetanus toxin fragment C: a novel protein delivery vector and its use with photochemical internalization. Journal of Drug Targeting. 21: 662-74. PMID 23697582 DOI: 10.3109/1061186X.2013.796954 |
0.384 |
|
| 2013 |
Xiao S, White JF, Betenbaugh MJ, Grisshammer R, Shiloach J. Transient and stable expression of the neurotensin receptor NTS1: a comparison of the baculovirus-insect cell and the T-REx-293 expression systems. Plos One. 8: e63679. PMID 23696845 DOI: 10.1371/Journal.Pone.0063679 |
0.452 |
|
| 2013 |
Kildegaard HF, Baycin-Hizal D, Lewis NE, Betenbaugh MJ. The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology. Current Opinion in Biotechnology. 24: 1102-7. PMID 23523260 DOI: 10.1016/J.Copbio.2013.02.007 |
0.465 |
|
| 2013 |
Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metabolic Engineering. 16: 87-94. PMID 23376592 DOI: 10.1016/J.Ymben.2012.12.004 |
0.731 |
|
| 2013 |
Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J. Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. Rna Biology. 10: 287-300. PMID 23353574 DOI: 10.4161/Rna.23339 |
0.671 |
|
| 2013 |
Bennun SV, Yarema KJ, Betenbaugh MJ, Krambeck FJ. Integration of the transcriptome and glycome for identification of glycan cell signatures. Plos Computational Biology. 9: e1002813. PMID 23326219 DOI: 10.1371/Journal.Pcbi.1002813 |
0.373 |
|
| 2012 |
Ohsfeldt E, Huang SH, Baycin-Hizal D, Kristoffersen L, Le TM, Li E, Hristova K, Betenbaugh MJ. Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines. Biotechnology and Applied Biochemistry. 59: 155-62. PMID 23586824 DOI: 10.1002/Bab.1000 |
0.501 |
|
| 2012 |
Baycin-Hizal D, Tabb DL, Chaerkady R, Chen L, Lewis NE, Nagarajan H, Sarkaria V, Kumar A, Wolozny D, Colao J, Jacobson E, Tian Y, O'Meally RN, Krag SS, Cole RN, ... ... Betenbaugh M, et al. Proteomic analysis of Chinese hamster ovary cells. Journal of Proteome Research. 11: 5265-76. PMID 22971049 DOI: 10.1021/Pr300476W |
0.419 |
|
| 2012 |
Druz A, Betenbaugh M, Shiloach J. Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation. Nucleic Acids Research. 40: 7291-302. PMID 22638581 DOI: 10.1093/Nar/Gks452 |
0.639 |
|
| 2012 |
Mastrangelo AJ, Hardwick JM, Betenbaugh MJ. Bcl-2 inhibits apoptosis and extends recombinant protein production in cells infected with Sindbis viral vectors. Cytotechnology. 22: 169-78. PMID 22358927 DOI: 10.1007/Bf00353936 |
0.523 |
|
| 2012 |
Majors BS, Chiang GG, Pederson NE, Betenbaugh MJ. Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation. Protein Engineering, Design & Selection : Peds. 25: 27-38. PMID 22160868 DOI: 10.1093/Protein/Gzr052 |
0.826 |
|
| 2012 |
Hammond S, Kaplarevic M, Borth N, Betenbaugh MJ, Lee KH. Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org. Biotechnology and Bioengineering. 109: 1353-6. PMID 22105744 DOI: 10.1002/Bit.24374 |
0.32 |
|
| 2012 |
Dorai H, Corisdeo S, Ellis D, Kinney C, Chomo M, Hawley-Nelson P, Moore G, Betenbaugh MJ, Ganguly S. Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins. Biotechnology and Bioengineering. 109: 1016-30. PMID 22068683 DOI: 10.1002/Bit.24367 |
0.488 |
|
| 2012 |
Zustiak MP, Dorai H, Betenbaugh MJ, Sauerwald TM. Controlling apoptosis to optimize yields of proteins from mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 801: 111-23. PMID 21987250 DOI: 10.1007/978-1-61779-352-3_8 |
0.817 |
|
| 2012 |
Shiloach J, Druz A, Betenbaugh M. MicroRNAs as engineering targets: Pathway manipulation to impact bioprocess phenotypes Micrornas as Tools in Biopharmaceutical Production. 2147483647: 65-85. DOI: 10.1007/978-94-007-5128-6_5 |
0.696 |
|
| 2011 |
Baycin-Hizal D, Mai S, Wolozny D, Akan I, Tomiya N, Palter K, Betenbaugh M. Measurement of sialic acid content on recombinant membrane proteins. Bmc Proceedings. 5: P59. PMID 22373179 DOI: 10.1186/1753-6561-5-S8-P59 |
0.348 |
|
| 2011 |
Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, ... ... Betenbaugh MJ, et al. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nature Biotechnology. 29: 735-41. PMID 21804562 DOI: 10.1038/Nbt.1932 |
0.413 |
|
| 2011 |
Wan M, Liu P, Xia J, Rosenberg JN, Oyler GA, Betenbaugh MJ, Nie Z, Qiu G. The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana. Applied Microbiology and Biotechnology. 91: 835-44. PMID 21698379 DOI: 10.1007/S00253-011-3399-8 |
0.351 |
|
| 2011 |
Baycin-Hizal D, Tian Y, Akan I, Jacobson E, Clark D, Wu A, Jampol R, Palter K, Betenbaugh M, Zhang H. GlycoFish: a database of zebrafish N-linked glycoproteins identified using SPEG method coupled with LC/MS. Analytical Chemistry. 83: 5296-303. PMID 21591763 DOI: 10.1021/Ac200726Q |
0.315 |
|
| 2011 |
Hayashi T, Lewis A, Hayashi E, Betenbaugh MJ, Su TP. Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones. Histochemistry and Cell Biology. 135: 627-37. PMID 21573736 DOI: 10.1007/S00418-011-0811-5 |
0.331 |
|
| 2011 |
Gillmeister MP, Betenbaugh MJ, Fishman PS. Cellular trafficking and photochemical internalization of cell penetrating peptide linked cargo proteins: a dual fluorescent labeling study. Bioconjugate Chemistry. 22: 556-66. PMID 21405111 DOI: 10.1021/Bc900445G |
0.789 |
|
| 2011 |
Druz A, Chu C, Majors B, Santuary R, Betenbaugh M, Shiloach J. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells. Biotechnology and Bioengineering. 108: 1651-61. PMID 21337326 DOI: 10.1002/Bit.23092 |
0.783 |
|
| 2010 |
Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ. Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines. Biotechnology Progress. 26: 1367-81. PMID 20945491 DOI: 10.1002/Btpr.426 |
0.508 |
|
| 2010 |
Chu C, Lugovtsev V, Lewis A, Betenbaugh M, Shiloach J. Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor. Vaccine. 28: 7193-201. PMID 20800699 DOI: 10.1016/J.Vaccine.2010.08.059 |
0.588 |
|
| 2010 |
Jones MB, Chu CH, Pendleton JC, Betenbaugh MJ, Shiloach J, Baljinnyam B, Rubin JS, Shamblott MJ. Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells and Development. 19: 1923-35. PMID 20367282 DOI: 10.1089/Scd.2009.0326 |
0.603 |
|
| 2010 |
Jones MB, Tomiya N, Betenbaugh MJ, Krag SS. Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells. Biochemical and Biophysical Research Communications. 395: 36-41. PMID 20331963 DOI: 10.1016/J.Bbrc.2010.03.117 |
0.426 |
|
| 2010 |
Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS. Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment. Journal of Biotechnology. 145: 143-59. PMID 19770009 DOI: 10.1016/J.Jbiotec.2009.09.008 |
0.43 |
|
| 2009 |
Chu C, Lugovtsev V, Golding H, Betenbaugh M, Shiloach J. Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production. Proceedings of the National Academy of Sciences of the United States of America. 106: 14802-7. PMID 19706449 DOI: 10.1073/Pnas.0905912106 |
0.655 |
|
| 2009 |
Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells. Biotechnology Progress. 25: 1161-8. PMID 19551877 DOI: 10.1002/Btpr.192 |
0.859 |
|
| 2009 |
Krambeck FJ, Bennun SV, Narang S, Choi S, Yarema KJ, Betenbaugh MJ. A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology. 19: 1163-75. PMID 19506293 DOI: 10.1093/Glycob/Cwp081 |
0.532 |
|
| 2009 |
Gillmeister MP, Tomiya N, Jacobia SJ, Lee YC, Gorfien SF, Betenbaugh MJ. An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: application to monitor glycan modulation by medium conditions. Glycoconjugate Journal. 26: 1135-49. PMID 19412663 DOI: 10.1007/S10719-009-9235-Z |
0.782 |
|
| 2009 |
O'Connor S, Li E, Majors BS, He L, Placone J, Baycin D, Betenbaugh MJ, Hristova K. Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expression and Purification. 67: 41-7. PMID 19376231 DOI: 10.1016/J.Pep.2009.04.007 |
0.837 |
|
| 2009 |
Majors BS, Chiang GG, Betenbaugh MJ. Protein and genome evolution in Mammalian cells for biotechnology applications. Molecular Biotechnology. 42: 216-23. PMID 19367473 DOI: 10.1007/S12033-009-9156-X |
0.83 |
|
| 2009 |
Dorai H, Kyung YS, Ellis D, Kinney C, Lin C, Jan D, Moore G, Betenbaugh MJ. Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture. Biotechnology and Bioengineering. 103: 592-608. PMID 19241388 DOI: 10.1002/Bit.22269 |
0.523 |
|
| 2009 |
Nivitchanyong T, Tsai YC, Betenbaugh MJ, Oyler GA. An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering. Virus Research. 141: 1-12. PMID 19200810 DOI: 10.1016/J.Virusres.2008.12.019 |
0.816 |
|
| 2008 |
Majors BS, Arden N, Oyler GA, Chiang GG, Pederson NE, Betenbaugh MJ. E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells. Journal of Biotechnology. 138: 103-6. PMID 18778741 DOI: 10.1016/J.Jbiotec.2008.08.003 |
0.842 |
|
| 2008 |
Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L). Biotechnology and Bioengineering. 101: 567-78. PMID 18727128 DOI: 10.1002/Bit.21917 |
0.854 |
|
| 2008 |
Rosenberg JN, Oyler GA, Wilkinson L, Betenbaugh MJ. A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution. Current Opinion in Biotechnology. 19: 430-6. PMID 18725295 DOI: 10.1016/J.Copbio.2008.07.008 |
0.312 |
|
| 2008 |
Zustiak MP, Pollack JK, Marten MR, Betenbaugh MJ. Feast or famine: autophagy control and engineering in eukaryotic cell culture. Current Opinion in Biotechnology. 19: 518-26. PMID 18725292 DOI: 10.1016/J.Copbio.2008.07.007 |
0.826 |
|
| 2008 |
Jaluria P, Chu C, Betenbaugh M, Shiloach J. Cells by design: a mini-review of targeting cell engineering using DNA microarrays. Molecular Biotechnology. 39: 105-11. PMID 18327555 DOI: 10.1007/S12033-008-9048-5 |
0.83 |
|
| 2008 |
Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J. Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates. Biotechnology and Bioengineering. 99: 1443-52. PMID 18023050 DOI: 10.1002/Bit.21707 |
0.829 |
|
| 2008 |
Hancock K, Narang S, Pattabhi S, Yushak ML, Khan A, Lin SC, Plemons R, Betenbaugh MJ, Tsang VC. False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five insect cells: effect of glycosylation. Journal of Immunological Methods. 330: 130-6. PMID 17868684 DOI: 10.1016/J.Jim.2007.08.002 |
0.645 |
|
| 2007 |
Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. Bmc Biotechnology. 7: 71. PMID 17945021 DOI: 10.1186/1472-6750-7-71 |
0.824 |
|
| 2007 |
Majors BS, Betenbaugh MJ, Chiang GG. Links between metabolism and apoptosis in mammalian cells: applications for anti-apoptosis engineering. Metabolic Engineering. 9: 317-26. PMID 17611135 DOI: 10.1016/J.Ymben.2007.05.003 |
0.839 |
|
| 2007 |
Nivitchanyong T, Martinez A, Ishaque A, Murphy JE, Konstantinov K, Betenbaugh MJ, Thrift J. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture. Biotechnology and Bioengineering. 98: 825-41. PMID 17514750 DOI: 10.1002/Bit.21479 |
0.835 |
|
| 2007 |
Arden N, Ahn SH, Vaz W, Rhodes M, Hancock C, Abitorabi MA, Betenbaugh MJ. Chemical caspase inhibitors enhance cell culture viabilities and protein titer. Biotechnology Progress. 23: 506-11. PMID 17381129 DOI: 10.1021/Bp060222M |
0.712 |
|
| 2007 |
Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J. A perspective on microarrays: current applications, pitfalls, and potential uses. Microbial Cell Factories. 6: 4. PMID 17254338 DOI: 10.1186/1475-2859-6-4 |
0.764 |
|
| 2007 |
Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J. Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells. Metabolic Engineering. 9: 241-51. PMID 17240181 DOI: 10.1016/J.Ymben.2006.12.001 |
0.837 |
|
| 2007 |
Arden N, Majors BS, Ahn SH, Oyler G, Betenbaugh MJ. Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures. Biotechnology and Bioengineering. 97: 601-14. PMID 17149774 DOI: 10.1002/Bit.21254 |
0.844 |
|
| 2007 |
Figueroa B, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ. Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells. Biotechnology and Bioengineering. 97: 877-92. PMID 17099908 DOI: 10.1002/Bit.21222 |
0.776 |
|
| 2006 |
Arden N, Betenbaugh MJ. Regulating apoptosis in mammalian cell cultures. Cytotechnology. 50: 77-92. PMID 19003072 DOI: 10.1007/S10616-006-9008-5 |
0.684 |
|
| 2006 |
Tomiya N, Narang S, Park J, Abdul-Rahman B, Choi O, Singh S, Hiratake J, Sakata K, Betenbaugh MJ, Palter KB, Lee YC. Purification, characterization, and cloning of a Spodoptera frugiperda Sf9 beta-N-acetylhexosaminidase that hydrolyzes terminal N-acetylglucosamine on the N-glycan core. The Journal of Biological Chemistry. 281: 19545-60. PMID 16684772 DOI: 10.1074/Jbc.M603312200 |
0.566 |
|
| 2006 |
Sauerwald TM, Figueroa B, Hardwick JM, Oyler GA, Betenbaugh MJ. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnology and Bioengineering. 94: 362-72. PMID 16598795 DOI: 10.1002/Bit.20874 |
0.825 |
|
| 2006 |
Viswanathan K, Tomiya N, Park J, Singh S, Lee YC, Palter K, Betenbaugh MJ. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. The Journal of Biological Chemistry. 281: 15929-40. PMID 16537535 DOI: 10.1074/Jbc.M512186200 |
0.584 |
|
| 2006 |
Betenbaugh MJ. The Effects of Expressing Anti-Apoptotic Genes On Mammalian Cell Survival, Physiology, and Protein Production Microbial Cell Factories. 5: 1-1. DOI: 10.1186/1475-2859-5-S1-S4 |
0.471 |
|
| 2005 |
Jones J, Krag SS, Betenbaugh MJ. Controlling N-linked glycan site occupancy. Biochimica Et Biophysica Acta. 1726: 121-37. PMID 16126345 DOI: 10.1016/J.Bbagen.2005.07.003 |
0.614 |
|
| 2005 |
Kim YK, Shin HS, Tomiya N, Lee YC, Betenbaugh MJ, Cha HJ. Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells. Biotechnology and Bioengineering. 92: 452-61. PMID 16025538 DOI: 10.1002/Bit.20605 |
0.469 |
|
| 2005 |
Jones J, Nivitchanyong T, Giblin C, Ciccarone V, Judd D, Gorfien S, Krag SS, Betenbaugh MJ. Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells. Biotechnology and Bioengineering. 91: 722-32. PMID 15981277 DOI: 10.1002/Bit.20566 |
0.84 |
|
| 2005 |
Viswanathan K, Narang S, Hinderlich S, Lee YC, Betenbaugh MJ. Engineering intracellular CMP-sialic acid metabolism into insect cells and methods to enhance its generation. Biochemistry. 44: 7526-34. PMID 15895995 DOI: 10.1021/Bi047477Y |
0.728 |
|
| 2005 |
Jones J, Viswanathan K, Krag SS, Betenbaugh MJ. Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase. Biochemical and Biophysical Research Communications. 331: 379-83. PMID 15850770 DOI: 10.1016/J.Bbrc.2005.03.181 |
0.753 |
|
| 2004 |
Tomiya N, Narang S, Lee YC, Betenbaugh MJ. Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines. Glycoconjugate Journal. 21: 343-60. PMID 15514482 DOI: 10.1023/B:Glyc.0000046275.28315.87 |
0.626 |
|
| 2004 |
Betenbaugh MJ, Tomiya N, Narang S, Hsu JT, Lee YC. Biosynthesis of human-type N-glycans in heterologous systems. Current Opinion in Structural Biology. 14: 601-6. PMID 15465322 DOI: 10.1016/J.Sbi.2004.09.001 |
0.607 |
|
| 2004 |
Arden N, Betenbaugh MJ. Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends in Biotechnology. 22: 174-80. PMID 15038922 DOI: 10.1016/J.Tibtech.2004.02.004 |
0.688 |
|
| 2004 |
Figueroa B, Chen S, Oyler GA, Hardwick JM, Betenbaugh MJ. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions. Biotechnology and Bioengineering. 85: 589-600. PMID 14966800 DOI: 10.1002/Bit.10913 |
0.774 |
|
| 2004 |
Betenbaugh M, Arden N, Nivitchanyong T. Cell Engineering Blocks Cell Stress and Improves Biotherapeutic Production Bioprocessing Journal. 3: 23-28. DOI: 10.12665/J32.Betenbaugh |
0.809 |
|
| 2003 |
Viswanathan K, Lawrence S, Hinderlich S, Yarema KJ, Lee YC, Betenbaugh MJ. Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them. Biochemistry. 42: 15215-25. PMID 14690432 DOI: 10.1021/Bi034994S |
0.737 |
|
| 2003 |
Figueroa B, Sauerwald TM, Oyler GA, Hardwick JM, Betenbaugh MJ. A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures. Metabolic Engineering. 5: 230-45. PMID 14642351 DOI: 10.1016/S1096-7176(03)00044-2 |
0.804 |
|
| 2003 |
Tomiya N, Betenbaugh MJ, Lee YC. Humanization of lepidopteran insect-cell-produced glycoproteins. Accounts of Chemical Research. 36: 613-20. PMID 12924958 DOI: 10.1021/Ar020202V |
0.434 |
|
| 2003 |
Choi O, Tomiya N, Kim JH, Slavicek JM, Betenbaugh MJ, Lee YC. N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system. Glycobiology. 13: 539-48. PMID 12672704 DOI: 10.1093/Glycob/Cwg071 |
0.374 |
|
| 2003 |
Tomiya N, Howe D, Aumiller JJ, Pathak M, Park J, Palter KB, Jarvis DL, Betenbaugh MJ, Lee YC. Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian [beta]-1,4-galactosyltransferase and [beta]-1,2-N-acetylglucosaminyltransferase II. Glycobiology. 13: 23-34. PMID 12634321 DOI: 10.1093/Glycob/Cwg012 |
0.342 |
|
| 2003 |
Sauerwald TM, Oyler GA, Betenbaugh MJ. Study of caspase inhibitors for limiting death in mammalian cell culture. Biotechnology and Bioengineering. 81: 329-40. PMID 12474256 DOI: 10.1002/Bit.10473 |
0.823 |
|
| 2002 |
Abdul-Rahman B, Ailor E, Jarvis D, Betenbaugh M, Lee YC. Beta-(1 --> 4)-galactosyltransferase activity in native and engineered insect cells measured with time-resolved europium fluorescence. Carbohydrate Research. 337: 2181-6. PMID 12433481 DOI: 10.1016/S0008-6215(02)00260-4 |
0.414 |
|
| 2002 |
Kim K, Lawrence SM, Park J, Pitts L, Vann WF, Betenbaugh MJ, Palter KB. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology. 12: 73-83. PMID 11886840 DOI: 10.1093/Glycob/12.2.73 |
0.614 |
|
| 2002 |
Sauerwald TM, Betenbaugh MJ, Oyler GA. Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants. Biotechnology and Bioengineering. 77: 704-16. PMID 11807766 DOI: 10.1002/Bit.10154 |
0.837 |
|
| 2002 |
Betenbaugh M, Sauerwald T. Apoptosis in Biotechnology: Its Role in Mammalian Cell Culture and Methods of Inhibition Bioprocessing Journal. 1: 61-68. DOI: 10.12665/J12.Betenbaugh |
0.817 |
|
| 2001 |
Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ. Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. Glycoconjugate Journal. 18: 205-13. PMID 11602804 DOI: 10.1023/A:1012452705349 |
0.683 |
|
| 2001 |
Tomiya N, Ailor E, Lawrence SM, Betenbaugh MJ, Lee YC. Determination of nucleotides and sugar nucleotides involved in protein glycosylation by high-performance anion-exchange chromatography: sugar nucleotide contents in cultured insect cells and mammalian cells. Analytical Biochemistry. 293: 129-37. PMID 11373089 DOI: 10.1006/Abio.2001.5091 |
0.683 |
|
| 2001 |
Figueroa B, Sauerwald TM, Mastrangelo AJ, Hardwick JM, Betenbaugh MJ. Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults. Biotechnology and Bioengineering. 73: 211-22. PMID 11257603 DOI: 10.1002/Bit.1053 |
0.838 |
|
| 2000 |
LeDuc PR, Whiteley EM, Bao G, Betenbaugh MJ. Investigating the secretory pathway of the baculovirus-insect cell system using a secretory green fluorescent protein Biotechnology Progress. 16: 716-723. PMID 11027162 DOI: 10.1021/Bp0001112 |
0.425 |
|
| 2000 |
Ailor E, Takahashi N, Tsukamoto Y, Masuda K, Rahman BA, Jarvis DL, Lee YC, Betenbaugh MJ. N-glycan patterns of human transferrin produced in Trichoplusia ni insect cells: Effects of mammalian galactosyltransferase Glycobiology. 10: 837-847. PMID 10929010 DOI: 10.1093/Glycob/10.8.837 |
0.365 |
|
| 2000 |
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability. The Journal of Biological Chemistry. 275: 17869-77. PMID 10749855 DOI: 10.1074/Jbc.M000217200 |
0.612 |
|
| 2000 |
Mastrangelo AJ, Hardwick JM, Zou S, Betenbaugh MJ. Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults. Biotechnology and Bioengineering. 67: 555-64. PMID 10649230 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<555::Aid-Bit6>3.0.Co;2-T |
0.507 |
|
| 2000 |
Mastrangelo AJ, Hardwick JM, Bex F, Betenbaugh MJ. Part I. Bcl-2 and Bcl-x(L) limit apoptosis upon infection with alphavirus vectors. Biotechnology and Bioengineering. 67: 544-54. PMID 10649229 DOI: 10.1002/(SICI)1097-0290(20000305)67:5<544::AID-BIT5>3.0.CO;2-# |
0.388 |
|
| 1999 |
Tate CG, Whiteley E, Betenbaugh MJ. Molecular chaperones improve functional expression of the serotonin (5-hydroxytryptamine) transporter in insect cells Biochemical Society Transactions. 27: 932-936. PMID 10830131 DOI: 10.1042/Bst0270932 |
0.35 |
|
| 1999 |
Mastrangelo AJ, Zou S, Hardwick JM, Betenbaugh MJ. Antiapoptosis chemicals prolong productive lifetimes of mammalian cells upon Sindbis virus vector infection. Biotechnology and Bioengineering. 65: 298-305. PMID 10486128 DOI: 10.1002/(Sici)1097-0290(19991105)65:3<298::Aid-Bit7>3.0.Co;2-S |
0.539 |
|
| 1999 |
Tate CG, Whiteley E, Betenbaugh MJ. Molecular chaperones stimulate the functional expression of the cocaine- sensitive serotonin transporter Journal of Biological Chemistry. 274: 17551-17558. PMID 10364189 DOI: 10.1074/Jbc.274.25.17551 |
0.316 |
|
| 1999 |
Ailor E, Betenbaugh MJ. Modifying secretion and post-translational processing in insect cells Current Opinion in Biotechnology. 10: 142-145. PMID 10209136 DOI: 10.1016/S0958-1669(99)80024-X |
0.444 |
|
| 1999 |
Ailor E, Pathmanathan J, Jongbloed JDH, Betenbaugh MJ. A bacterial signal peptidase enhances processing of a recombinant single chain antibody fragment in insect cells Biochemical and Biophysical Research Communications. 255: 444-450. PMID 10049728 DOI: 10.1006/Bbrc.1999.0233 |
0.37 |
|
| 1998 |
Ailor E, Betenbaugh MJ. Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells Biotechnology and Bioengineering. 58: 196-203. PMID 10191390 DOI: 10.1002/(Sici)1097-0290(19980420)58:2/3<196::Aid-Bit12>3.0.Co;2-B |
0.387 |
|
| 1998 |
Mastrangelo AJ, Betenbaugh MJ. Overcoming apoptosis: New methods for improving protein-expression systems Trends in Biotechnology. 16: 88-95. PMID 9487737 DOI: 10.1016/S0167-7799(97)01159-1 |
0.489 |
|
| 1997 |
Whiteley EM, Hsu TA, Betenbaugh MJ. Thioredoxin domain non-equivalence and anti-chaperone activity of protein disulfide isomerase mutants in vivo Journal of Biological Chemistry. 272: 22556-22563. PMID 9278409 DOI: 10.1074/Jbc.272.36.22556 |
0.376 |
|
| 1997 |
Hsu TA, Takahashi N, Tsukamoto Y, Kato K, Shimada I, Masuda K, Whiteley EM, Fan JQ, Lee YC, Betenbaugh MJ. Differential N-glycan patterns of secreted and intracellular IgG produced in Trichoplusia ni cells. The Journal of Biological Chemistry. 272: 9062-70. PMID 9083032 DOI: 10.1074/Jbc.272.14.9062 |
0.36 |
|
| 1997 |
Hsu TA, Betenbaugh MJ. Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from trichoplusia ni insect cells Biotechnology Progress. 13: 96-104. PMID 9041711 DOI: 10.1021/Bp960088D |
0.412 |
|
| 1997 |
Whiteley EM, Hsu TA, Betenbaugh MJ. Modeling assembly, aggregation, and chaperoning of immunoglobulin G production in insect cells Biotechnology and Bioengineering. 56: 106-116. DOI: 10.1002/(Sici)1097-0290(19971005)56:1<106::Aid-Bit12>3.0.Co;2-I |
0.368 |
|
| 1996 |
Hsu TA, Watson S, Eiden JJ, Betenbaugh MJ. Rescue of immunoglobulins from insolubility is facilitated by PDI in the baculovirus expression system Protein Expression and Purification. 7: 281-288. PMID 8860653 DOI: 10.1006/Prep.1996.0040 |
0.391 |
|
| 1996 |
Betenbaugh MJ, Ailor E, Whiteley E, Hinderliter P, Hsu TA. Chaperone and foldase coexpression in the baculovirus-insect cell expression system Cytotechnology. 20: 149-159. DOI: 10.1007/Bf00350396 |
0.453 |
|
| 1996 |
Mastrangelo AJ, Marie Hardwick J, Betenbaugh MJ. Bcl-2 inhibits apoptosis and extends recombinant protein production in cells infected with Sindbis viral vectors Cytotechnology. 22: 169-178. |
0.428 |
|
| 1995 |
Betenbaugh M, Yu M, Kuehl K, White J, Pennock D, Spik K, Schmaljohn C. Nucleocapsid- and virus-like particles assemble in cells infected with recombinant baculoviruses or vaccinia viruses expressing the M and the S segments of Hantaan virus. Virus Research. 38: 111-24. PMID 8578853 DOI: 10.1016/0168-1702(95)00053-S |
0.339 |
|
| 1995 |
Mastrangelo AJ, Betenbaugh MJ. Implications and applications of apoptosis in cell culture Current Opinion in Biotechnology. 6: 198-202. PMID 7734748 DOI: 10.1016/0958-1669(95)80032-8 |
0.501 |
|
| 1994 |
Hsu TA, Eiden JJ, Betenbaugh MJ. Engineering the assembly pathway of the baculovirus-insect cell expression system Annals of the New York Academy of Sciences. 721: 208-217. PMID 8010671 DOI: 10.1111/j.1749-6632.1994.tb47393.x |
0.345 |
|
| 1994 |
Hsu TA, Eiden JJ, Bourgarel P, Meo T, Betenbaugh MJ. Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system Protein Expression and Purification. 5: 595-603. PMID 7858430 DOI: 10.1006/Prep.1994.1082 |
0.406 |
|
| 1993 |
Juarbeosorio LG, Gorziglia M, Betenbaugh MJ. Recovery and Characterization of a Rotavirus Outer Capsid Protein Expressed in a Recombinant Insect Cell System Protein Expression and Purification. 4: 232-239. PMID 8390880 DOI: 10.1006/Prep.1993.1030 |
0.357 |
|
| 1993 |
Lindsay DA, Vonderfecht SL, Betenbaugh MJ, Eiden JJ. Baculovirus expression of gene 6 of the IDIR strain of group B rotavirus (GBR): Coding assignment of the major inner capsid protein Virology. 193: 367-375. PMID 8382401 DOI: 10.1006/Viro.1993.1133 |
0.353 |
|
| 1993 |
Lindsay DA, Vonderfecht SS, Willoughby R, Betenbaugh MJ, Eiden JJ. Identification and expression of the outer capsid protein (VP4) of the IDIR strain of group B rotavirus Virology. 194: 724-733. PMID 7684874 DOI: 10.1006/Viro.1993.1313 |
0.35 |
|
| 1992 |
Betenbaugh MJ, Lindsay DA, Juarbe-Osorio LG, Gorziglia M, Vonderfecht S, Eiden JJ. Genetically engineered viral antigens from insect cell culture Annals of the New York Academy of Sciences. 665: 210-218. PMID 1329599 DOI: 10.1111/J.1749-6632.1992.Tb42585.X |
0.376 |
|
| 1992 |
Lindsay DA, Betenbaugh MJ. Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells Biotechnology and Bioengineering. 39: 614-618. DOI: 10.1002/Bit.260390605 |
0.447 |
|
| 1991 |
Betenbaugh MJ, Balog L, Lee PS. Production of recombinant proteins by baculovirus-infected gypsy moth cells. Biotechnology Progress. 7: 462-467. PMID 1367995 DOI: 10.1021/Bp00011A012 |
0.484 |
|
| 1990 |
Betenbaugh MJ, Dhurjati P. Effects of promoter induction and copy number amplification on cloned gene expression and growth of recombinant cell cultures Annals of the New York Academy of Sciences. 589: 111-120. PMID 2192653 DOI: 10.1111/J.1749-6632.1990.Tb24238.X |
0.681 |
|
| 1990 |
Betenbaugh MJ, Dhurjati P. A comparison of mathematical model predictions to experimental measurements for growth and recombinant protein production in induced cultures of Escherichia coli Biotechnology and Bioengineering. 36: 124-134. DOI: 10.1002/Bit.260360204 |
0.642 |
|
| 1989 |
Betenbaugh MJ, Beaty C, Dhurjati P. Effects of plasmid amplification and recombinant gene expression on the growth kinetics of recombinant E. coli Biotechnology and Bioengineering. 33: 1425-1436. DOI: 10.1002/Bit.260331110 |
0.652 |
|
| 1987 |
Hopkins DJ, Betenbaugh MJ, Dhurjati P. Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401. Biotechnology and Bioengineering. 29: 85-91. PMID 18561133 DOI: 10.1002/Bit.260290113 |
0.653 |
|
| 1987 |
Betenbaugh MJ, DiPasquantonio VM, Dhurjati P. Growth kinetics of Escherichia coli containing temperature-sensitive plasmid pOU140 Biotechnology and Bioengineering. 29: 1164-1172. DOI: 10.1002/Bit.260290918 |
0.651 |
|
| 1987 |
diPasquantonio VM, Betenbaugh MJ, Dhurjati P. Improvement of product yields by temperature-shifting of Escherichia coli cultures containing plasmid pOU140 Biotechnology and Bioengineering. 29: 513-519. DOI: 10.1002/Bit.260290416 |
0.658 |
|
| 1987 |
Hopkins DJ, Betenbaugh MJ, Dhurjati P. Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401 Biotechnology and Bioengineering. 29: 85-91. DOI: 10.1002/bit.260290113 |
0.619 |
|
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