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Michael J. Betenbaugh - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Chemical Engineering, Biochemistry
Website:
https://engineering.jhu.edu/chembe/faculty/michael-j-betenbaugh/

200 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zuñiga C, Li T, Guarnieri MT, Jenkins JP, Li CT, Bingol K, Kim YM, Betenbaugh MJ, Zengler K. Synthetic microbial communities of heterotrophs and phototrophs facilitate sustainable growth. Nature Communications. 11: 3803. PMID 32732991 DOI: 10.1038/S41467-020-17612-8  0.6
2020 Whitehead TA, Banta S, Bentley WE, Betenbaugh MJ, Chan C, Clark DS, Hoesli CA, Jewett MC, Junker B, Koffas M, Kshirsagar R, Lewis A, Li CT, Maranas C, Terry Papoutsakis E, et al. The Importance and Future of Biochemical Engineering. Biotechnology and Bioengineering. PMID 32343367 DOI: 10.1002/Bit.27364  0.6
2020 Gutierrez JM, Feizi A, Li S, Kallehauge TB, Hefzi H, Grav LM, Ley D, Baycin Hizal D, Betenbaugh MJ, Voldborg B, Faustrup Kildegaard H, Min Lee G, Palsson BO, Nielsen J, Lewis NE. Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. Nature Communications. 11: 68. PMID 31896772 DOI: 10.1038/S41467-019-13867-Y  0.4
2020 Inwood S, Abaandou L, Betenbaugh M, Shiloach J. Improved protein expression in HEK293 cells by over-expressing miR-22 and knocking-out its target gene, HIPK1 New Biotechnology. 54: 28-33. DOI: 10.1016/J.Nbt.2019.08.004  0.56
2019 Li CT, Yelsky J, Chen Y, Zuñiga C, Eng R, Jiang L, Shapiro A, Huang KW, Zengler K, Betenbaugh MJ. Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity. Npj Systems Biology and Applications. 5: 33. PMID 32963233 DOI: 10.1038/s41540-019-0110-7  0.6
2019 Zuñiga C, Li CT, Yu G, Al-Bassam MM, Li T, Jiang L, Zaramela LS, Guarnieri M, Betenbaugh MJ, Zengler K. Author Correction: Environmental stimuli drive a transition from cooperation to competition in synthetic phototrophic communities. Nature Microbiology. PMID 31690826 DOI: 10.1038/S41564-019-0621-4  0.6
2019 Zuñiga C, Li CT, Yu G, Al-Bassam MM, Li T, Jiang L, Zaramela LS, Guarnieri M, Betenbaugh MJ, Zengler K. Environmental stimuli drive a transition from cooperation to competition in synthetic phototrophic communities. Nature Microbiology. PMID 31591554 DOI: 10.1038/S41564-019-0567-6  0.6
2019 Li CT, Yelsky J, Chen Y, Zuñiga C, Eng R, Jiang L, Shapiro A, Huang KW, Zengler K, Betenbaugh MJ. Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity. Npj Systems Biology and Applications. 5: 33. PMID 31583115 DOI: 10.1038/s41540-019-0110-7  0.6
2019 Chen Y, McConnell BO, Gayatri Dhara V, Mukesh Naik H, Li CT, Antoniewicz MR, Betenbaugh MJ. An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells. Npj Systems Biology and Applications. 5: 25. PMID 31341637 DOI: 10.1038/s41540-019-0103-6  0.6
2019 Li S, Cha SW, Hefner K, Hizal DB, Bowen MA, Chaerkady R, Cole RN, Tejwani V, Kaushik P, Henry M, Meleady P, Sharfstein ST, Betenbaugh MJ, Bafna V, Lewis NE. Proteogenomic annotation of the Chinese hamster reveals extensive novel translation events and endogenous retroviral elements. Journal of Proteome Research. PMID 31020842 DOI: 10.1021/Acs.Jproteome.8B00935  0.4
2019 Bohutskyi P, Phan D, Spierling RE, Kopachevsky AM, Bouwer EJ, Lundquist TJ, Betenbaugh MJ. Production of lipid-containing algal-bacterial polyculture in wastewater and biomethanation of lipid extracted residues: Enhancing methane yield through hydrothermal pretreatment and relieving solvent toxicity through co-digestion. The Science of the Total Environment. 653: 1377-1394. PMID 30759577 DOI: 10.1016/J.Scitotenv.2018.11.026  0.36
2018 Inwood S, Betenbaugh MJ, Lal M, Shiloach J. Genome-Wide High-Throughput RNAi Screening for Identification of Genes Involved in Protein Production. Methods in Molecular Biology (Clifton, N.J.). 1850: 209-219. PMID 30242689 DOI: 10.1007/978-1-4939-8730-6_14  0.56
2018 Bohutskyi P, Phan D, Kopachevsky AM, Chow S, Bouwer EJ, Betenbaugh MJ. Synergistic co-digestion of wastewater grown algae-bacteria polyculture biomass and cellulose to optimize carbon-to-nitrogen ratio and application of kinetic models to predict anaerobic digestion energy balance. Bioresource Technology. 269: 210-220. PMID 30173067 DOI: 10.1016/J.Biortech.2018.08.085  0.36
2018 Inwood S, Xu H, Black MA, Betenbaugh MJ, Feldman S, Shiloach J. Continuous production process of retroviral vector for adoptive T- cell therapy. Biochemical Engineering Journal. 132: 145-151. PMID 29977134 DOI: 10.1016/J.Bej.2018.01.010  0.56
2018 Rupp O, MacDonald ML, Li S, Dhiman H, Polson S, Griep S, Heffner K, Hernandez I, Brinkrolf K, Jadhav V, Samoudi M, Hao H, Kingham B, Goesmann A, Betenbaugh MJ, et al. A reference genome of the Chinese hamster based on a hybrid assembly strategy. Biotechnology and Bioengineering. PMID 29704459 DOI: 10.1002/Bit.26722  0.4
2018 Inwood S, Betenbaugh MJ, Shiloach J. Methods for Using Small Non-Coding RNAs to Improve Recombinant Protein Expression in Mammalian Cells. Genes. 9. PMID 29315258 DOI: 10.3390/Genes9010025  0.56
2018 Goudar C, McFarland K, Betenbaugh M. Editorial overview: Latest Advances and Current Challenges in Biomanufacturing Current Opinion in Chemical Engineering. 22. DOI: 10.1016/J.Coche.2018.12.002  0.56
2018 Park J, Inwood S, Kruthiventi S, Jenkins J, Shiloach J, Betenbaugh M. Progressing from transient to stable packaging cell lines for continuous production of lentiviral and gammaretroviral vectors Current Opinion in Chemical Engineering. 22: 128-137. DOI: 10.1016/J.Coche.2018.09.007  0.56
2018 Jenkins J, Park J, Petersen K, Shajihan K, Kruthiventi S, Betenbaugh M. Adoptive T cell therapy: engineering and biomanufacturing chimeric antigen receptor-T cell Current Opinion in Chemical Engineering. 22: 26-33. DOI: 10.1016/J.Coche.2018.08.006  0.56
2017 Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J. Identifying HIPK1 as target of miR-22-3p enhancing recombinant protein production from HEK 293 cell by using microarray and HTP siRNA screen. Biotechnology Journal. PMID 28987030 DOI: 10.1002/Biot.201700342  0.56
2017 Zuniga C, Levering J, Antoniewicz MR, Guarnieri MT, Betenbaugh MJ, Zengler K. Predicting dynamic metabolic demands in the photosynthetic eukaryote Chlorella vulgaris. Plant Physiology. PMID 28951490 DOI: 10.1104/Pp.17.00605  0.6
2017 Vcelar S, Jadhav V, Melcher M, Auer N, Hrdina A, Sagmeister R, Heffner K, Puklowski A, Betenbaugh M, Wenger T, Leisch F, Baumann M, Borth N. Karyotype variation of CHO host cell lines over time in culture characterized by chromosome counting and chromosome painting. Biotechnology and Bioengineering. PMID 28921524 DOI: 10.1002/Bit.26453  0.36
2017 Heffner KM, Hizal DB, Yerganian GS, Kumar A, Can Ö, O'Meally RN, Cole R, Chaerkady R, Wu H, Bowen MA, Betenbaugh MJ. Lessons from the hamster: Cricetulus griseus tissue and CHO cell line proteome comparison. Journal of Proteome Research. PMID 28876938 DOI: 10.1021/Acs.Jproteome.7B00382  0.36
2017 Krambeck FJ, Bennun SV, Andersen MR, Betenbaugh MJ. Model-based analysis of N-glycosylation in Chinese hamster ovary cells. Plos One. 12: e0175376. PMID 28486471 DOI: 10.1371/Journal.Pone.0175376  0.4
2017 Li T, Li CT, Butler K, Hays SG, Guarnieri MT, Oyler GA, Betenbaugh MJ. Mimicking lichens: incorporation of yeast strains together with sucrose-secreting cyanobacteria improves survival, growth, ROS removal, and lipid production in a stable mutualistic co-culture production platform. Biotechnology For Biofuels. 10: 55. PMID 28344645 DOI: 10.1186/S13068-017-0736-X  0.72
2016 Zhang Y, Baycin Hizal D, Kumar A, Priola J, Bahri M, Heffner KM, Wang M, Han X, Bowen MA, Betenbaugh MJ. High-troughput Lipidomic and Transcriptomic Analysis to Compare SP2/0, CHO, and HEK-293 Mammalian Cell Lines. Analytical Chemistry. PMID 27991764 DOI: 10.1021/Acs.Analchem.6B02984  0.6
2016 Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, ... ... Betenbaugh MJ, et al. A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. Cell Systems. 3: 434-443.e8. PMID 27883890 DOI: 10.1016/J.Cels.2016.10.020  0.4
2016 Bohutskyi P, Chow S, Ketter B, Fung Shek C, Yacar D, Tang Y, Zivojnovich M, Betenbaugh MJ, Bouwer EJ. Phytoremediation of agriculture runoff by filamentous algae poly-culture for biomethane production, and nutrient recovery for secondary cultivation of lipid generating microalgae. Bioresource Technology. 222: 294-308. PMID 27728832 DOI: 10.1016/J.Biortech.2016.10.013  1
2016 Zuñiga C, Li CT, Huelsman T, Levering J, Zielinski DC, McConnell BO, Long CP, Knoshaug EP, Guarnieri MT, Antoniewicz MR, Betenbaugh MJ, Zengler K. Genome-scale metabolic model for the green alga Chlorella vulgaris UTEX 395 accurately predicts phenotypes under autotrophic, heterotrophic, and mixotrophic growth conditions. Plant Physiology. PMID 27372244 DOI: 10.1104/Pp.16.00593  1
2016 Priola JJ, Calzadilla N, Baumann M, Borth N, Tate CG, Betenbaugh MJ. High-throughput screening and selection of mammalian cells for enhanced protein production. Biotechnology Journal. PMID 27276699 DOI: 10.1002/Biot.201500579  1
2016 Xiao S, Chen YC, Buehler E, Mandal S, Mandal A, Betenbaugh M, Park MH, Martin S, Shiloach J. Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells. Biotechnology and Bioengineering. PMID 27215166 DOI: 10.1002/Bit.26017  1
2016 Williams A, Hayashi T, Wolozny D, Yin B, Su TC, Betenbaugh MJ, Su TP. The non-apoptotic action of Bcl-xL: regulating Ca(2+) signaling and bioenergetics at the ER-mitochondrion interface. Journal of Bioenergetics and Biomembranes. PMID 27155879 DOI: 10.1007/S10863-016-9664-X  1
2016 Baker JJ, Crivellari F, Gagnon Z, Betenbaugh MJ. Microfluidic bubbler facilitates near complete mass transfer for sustainable multiphase and microbial processing. Biotechnology and Bioengineering. PMID 26928403 DOI: 10.1002/Bit.25972  1
2016 Chu C, Bottaro DP, Betenbaugh MJ, Shiloach J. Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells. Plos One. 11: e0148075. PMID 26848584 DOI: 10.1371/Journal.Pone.0148075  1
2016 Gramlich PA, Westbroek W, Feldman RA, Awad O, Mello N, Remington MP, Sun Y, Zhang W, Sidransky E, Betenbaugh MJ, Fishman PS. A Peptide-Linked Recombinant Glucocerebrosidase for Targeted Neuronal Delivery: Design, Production, and Assessment. Journal of Biotechnology. PMID 26795355 DOI: 10.1016/J.Jbiotec.2016.01.015  1
2016 Tang Y, Zhang Y, Rosenberg J, Betenbaugh M, Wang F. Optimization of One-Step In Situ Transesterification Method for Accurate Quantification of EPA in Nannochloropsis gaditana Applied Sciences. 6: 343. DOI: 10.3390/App6110343  0.6
2016 Tang Y, Rosenberg JN, Bohutskyi P, Yu G, Betenbaugh MJ, Wang F. Microalgae as a feedstock for biofuel precursors and value-added products: Green fuels and golden opportunities Bioresources. 11: 2850-2885. DOI: 10.15376/Biores.11.1.Tang  1
2016 Tang Y, Zhang Y, Rosenberg JN, Sharif N, Betenbaugh MJ, Wang F. Efficient lipid extraction and quantification of fatty acids from algal biomass using accelerated solvent extraction (ASE) Rsc Advances. 6: 29127-29134. DOI: 10.1039/C5Ra23519G  0.6
2016 Bohutskyi P, Kligerman DC, Byers N, Nasr LK, Cua C, Chow S, Su C, Tang Y, Betenbaugh MJ, Bouwer EJ. Effects of inoculum size, light intensity, and dose of anaerobic digestion centrate on growth and productivity of Chlorella and Scenedesmus microalgae and their poly-culture in primary and secondary wastewater Algal Research. 19: 278-290. DOI: 10.1016/J.Algal.2016.09.010  1
2015 Yang S, Wang M, Chen L, Yin B, Song G, Turko IV, Phinney KW, Betenbaugh MJ, Zhang H, Li S. QUANTITY: An Isobaric Tag for Quantitative Glycomics. Scientific Reports. 5: 17585. PMID 26616285 DOI: 10.1038/Srep17585  1
2015 Kumar A, Baycin-Hizal D, Zhang Y, Bowen MA, Betenbaugh MJ. Cellular traffic cops: the interplay between lipids and proteins regulates vesicular formation, trafficking, and signaling in mammalian cells. Current Opinion in Biotechnology. 36: 215-221. PMID 26540512 DOI: 10.1016/J.Copbio.2015.09.006  1
2015 Yu G, Rosenberg JN, Betenbaugh MJ, Oyler GA. Pac-Man for biotechnology: co-opting degrons for targeted protein degradation to control and alter cell function. Current Opinion in Biotechnology. 36: 199-204. PMID 26435348 DOI: 10.1016/J.Copbio.2015.08.023  1
2015 Kumar A, Baycin-Hizal D, Wolozny D, Pedersen LE, Lewis NE, Heffner K, Chaerkady R, Cole RN, Shiloach J, Zhang H, Bowen MA, Betenbaugh MJ. Elucidation of the CHO Super-Ome (CHO-SO) by ProteoInfomatics. Journal of Proteome Research. PMID 26418914 DOI: 10.1021/Acs.Jproteome.5B00588  1
2015 Kobayashi N, Barnes A, Jensen T, Noel E, Andlay G, Rosenberg JN, Betenbaugh MJ, Guarnieri MT, Oyler GA. Comparison of biomass and lipid production under ambient carbon dioxide vigorous aeration and 3% carbon dioxide condition among the lead candidate Chlorella strains screened by various photobioreactor scales. Bioresource Technology. 198: 246-255. PMID 26398668 DOI: 10.1016/J.Biortech.2015.08.124  1
2015 Yin B, Gao Y, Chung CY, Yang S, Blake E, Stuczynski MC, Tang J, Kildegaard HF, Andersen MR, Zhang H, Betenbaugh MJ. Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation. Biotechnology and Bioengineering. PMID 26154505 DOI: 10.1002/Bit.25650  1
2015 Wang Q, Stuczynski M, Gao Y, Betenbaugh MJ. Strategies for Engineering Protein N-Glycosylation Pathways in Mammalian Cells. Methods in Molecular Biology (Clifton, N.J.). 1321: 287-305. PMID 26082230 DOI: 10.1007/978-1-4939-2760-9_20  1
2015 Viswanathan K, Narang S, Betenbaugh MJ. Engineering Sialic Acid Synthesis Ability in Insect Cells. Methods in Molecular Biology (Clifton, N.J.). 1321: 171-8. PMID 26082222 DOI: 10.1007/978-1-4939-2760-9_12  1
2015 Chung CY, Yin B, Wang Q, Chuang KY, Chu JH, Betenbaugh MJ. Assessment of the coordinated role of ST3GAL3, ST3GAL4 and ST3GAL6 on the α2,3 sialylation linkage of mammalian glycoproteins. Biochemical and Biophysical Research Communications. 463: 211-5. PMID 25998389 DOI: 10.1016/J.Bbrc.2015.05.023  1
2015 Bohutskyi P, Liu K, Nasr LK, Byers N, Rosenberg JN, Oyler GA, Betenbaugh MJ, Bouwer EJ. Bioprospecting of microalgae for integrated biomass production and phytoremediation of unsterilized wastewater and anaerobic digestion centrate. Applied Microbiology and Biotechnology. 99: 6139-54. PMID 25947241 DOI: 10.1007/S00253-015-6603-4  1
2015 Fan Y, Del Val IJ, Müller C, Lund AM, Sen JW, Rasmussen SK, Kontoravdi C, Baycin-Hizal D, Betenbaugh MJ, Weilguny D, Andersen MR. A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture. Biotechnology and Bioengineering. PMID 25899530 DOI: 10.1002/Bit.25620  1
2015 Kaas CS, Kristensen C, Betenbaugh MJ, Andersen MR. Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy. Bmc Genomics. 16: 160. PMID 25887056 DOI: 10.1186/S12864-015-1391-X  1
2015 Kumar A, Shiloach J, Betenbaugh MJ, Gallagher EJ. The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice. Nutrition & Metabolism. 12: 8. PMID 25784953 DOI: 10.1186/S12986-015-0003-8  1
2015 Bohutskyi P, Ketter B, Chow S, Adams KJ, Betenbaugh MJ, Allnutt FC, Bouwer EJ. Anaerobic digestion of lipid-extracted Auxenochlorella protothecoides biomass for methane generation and nutrient recovery. Bioresource Technology. 183: 229-39. PMID 25746299 DOI: 10.1016/J.Biortech.2015.02.012  1
2015 Xiao S, Chen YC, Betenbaugh MJ, Martin SE, Shiloach J. MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK 293 cells. Biotechnology and Bioengineering. 112: 1632-43. PMID 25676429 DOI: 10.1002/Bit.25567  1
2015 Kumar A, Baycin-Hizal D, Shiloach J, Bowen MA, Betenbaugh MJ. Coupling enrichment methods with proteomics for understanding and treating disease. Proteomics. Clinical Applications. 9: 33-47. PMID 25523641 DOI: 10.1002/Prca.201400097  1
2015 Gopalakrishnan S, Baker J, Kristoffersen L, Betenbaugh MJ. Redistribution of metabolic fluxes in Chlorella protothecoides by variation of media nitrogen concentration Metabolic Engineering Communications. 2: 124-131. DOI: 10.1016/J.Meteno.2015.09.004  1
2015 Apostolidis PA, Tseng A, Koziol ME, Betenbaugh MJ, Chiang B. Investigation of low viability in sparged bioreactor CHO cell cultures points to variability in the Pluronic F-68 shear protecting component of cell culture media Biochemical Engineering Journal. 98: 10-17. DOI: 10.1016/J.Bej.2015.01.013  1
2015 Bohutskyi P, Chow S, Ketter B, Betenbaugh MJ, Bouwer EJ. Prospects for methane production and nutrient recycling from lipid extracted residues and whole Nannochloropsis salina using anaerobic digestion Applied Energy. 154: 718-731. DOI: 10.1016/J.Apenergy.2015.05.069  1
2015 Rosenberg JN, Oh VH, Yu G, Guzman BJ, Oyler GA, Betenbaugh MJ. Chapter 22 - Exploiting the Molecular Genetics of Microalgae: From Strain Development Pipelines to the Uncharted Waters of Mass Production Handbook of Marine Microalgae: Biotechnology Advances. 331-352. DOI: 10.1016/B978-0-12-800776-1.00022-4  1
2014 Wan M, Jin X, Xia J, Rosenberg JN, Yu G, Nie Z, Oyler GA, Betenbaugh MJ. The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Applied Microbiology and Biotechnology. 98: 9473-81. PMID 25248441 DOI: 10.1007/S00253-014-6088-6  1
2014 Kumar A, Harrelson T, Lewis NE, Gallagher EJ, LeRoith D, Shiloach J, Betenbaugh MJ. Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice. Plos One. 9: e102319. PMID 25029527 DOI: 10.1371/Journal.Pone.0102319  1
2014 Templeton N, Lewis A, Dorai H, Qian EA, Campbell MP, Smith KD, Lang SE, Betenbaugh MJ, Young JD. The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism. Metabolic Engineering. 25: 92-102. PMID 25014175 DOI: 10.1016/J.Ymben.2014.06.010  1
2014 Heffner KM, Hizal DB, Kumar A, Shiloach J, Zhu J, Bowen MA, Betenbaugh MJ. Exploiting the proteomics revolution in biotechnology: from disease and antibody targets to optimizing bioprocess development. Current Opinion in Biotechnology. 30: 80-6. PMID 24997444 DOI: 10.1016/J.Copbio.2014.06.006  1
2014 Baycin-Hizal D, Gottschalk A, Jacobson E, Mai S, Wolozny D, Zhang H, Krag SS, Betenbaugh MJ. Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function. Biochemical and Biophysical Research Communications. 453: 243-53. PMID 24971539 DOI: 10.1016/J.Bbrc.2014.06.067  1
2014 Bohutskyi P, Liu K, Kessler BA, Kula T, Hong Y, Bouwer EJ, Betenbaugh MJ, Allnutt FC. Mineral and non-carbon nutrient utilization and recovery during sequential phototrophic-heterotrophic growth of lipid-rich algae. Applied Microbiology and Biotechnology. 98: 5261-73. PMID 24839256 DOI: 10.1007/S00253-014-5655-1  1
2014 Ronda C, Pedersen LE, Hansen HG, Kallehauge TB, Betenbaugh MJ, Nielsen AT, Kildegaard HF. Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool. Biotechnology and Bioengineering. 111: 1604-16. PMID 24827782 DOI: 10.1002/Bit.25233  1
2014 Xiao S, Shiloach J, Betenbaugh MJ. Engineering cells to improve protein expression. Current Opinion in Structural Biology. 26: 32-8. PMID 24704806 DOI: 10.1016/J.Sbi.2014.03.005  1
2014 Rosenberg JN, Kobayashi N, Barnes A, Noel EA, Betenbaugh MJ, Oyler GA. Comparative analyses of three Chlorella species in response to light and sugar reveal distinctive lipid accumulation patterns in the Microalga C. sorokiniana. Plos One. 9: e92460. PMID 24699196 DOI: 10.1371/Journal.Pone.0092460  1
2014 Zustiak MP, Jose L, Xie Y, Zhu J, Betenbaugh MJ. Enhanced transient recombinant protein production in CHO cells through the co-transfection of the product gene with Bcl-xL. Biotechnology Journal. 9: 1164-74. PMID 24604826 DOI: 10.1002/Biot.201300468  1
2014 Bohutskyi P, Betenbaugh MJ, Bouwer EJ. The effects of alternative pretreatment strategies on anaerobic digestion and methane production from different algal strains. Bioresource Technology. 155: 366-72. PMID 24468544 DOI: 10.1016/J.Biortech.2013.12.095  1
2014 Lewis A, Hayashi T, Su TP, Betenbaugh MJ. Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival. Journal of Bioenergetics and Biomembranes. 46: 1-15. PMID 24078116 DOI: 10.1007/S10863-013-9527-7  1
2014 Kumar A, Heffner KM, Shiloach J, Betenbaugh MJ, Baycin-Hizal D. Harnessing Chinese hamster ovary cell proteomics for biopharmaceutical processing Pharmaceutical Bioprocessing. 2: 421-435. DOI: 10.4155/Pbp.14.49  0.56
2014 Hizal DB, Wolozny D, Colao J, Jacobson E, Tian Y, Krag SS, Betenbaugh MJ, Zhang H. Glycoproteomic and glycomic databases Clinical Proteomics. 11. DOI: 10.1186/1559-0275-11-15  1
2014 Rogers JN, Rosenberg JN, Guzman BJ, Oh VH, Mimbela LE, Ghassemi A, Betenbaugh MJ, Oyler GA, Donohue MD. A critical analysis of paddlewheel-driven raceway ponds for algal biofuel production at commercial scales Algal Research. 4: 76-88. DOI: 10.1016/J.Algal.2013.11.007  1
2014 Bohutskyi P, Kula T, Kessler BA, Hong Y, Bouwer EJ, Betenbaugh MJ, Allnutt FCT. Mixed Trophic State Production Process for Microalgal Biomass with High Lipid Content for Generating Biodiesel and Biogas Bioenergy Research. 7: 1174-1185. DOI: 10.1007/S12155-014-9453-5  1
2013 Jadhav V, Hackl M, Druz A, Shridhar S, Chung CY, Heffner KM, Kreil DP, Betenbaugh M, Shiloach J, Barron N, Grillari J, Borth N. CHO microRNA engineering is growing up: recent successes and future challenges. Biotechnology Advances. 31: 1501-13. PMID 23916872 DOI: 10.1016/J.Biotechadv.2013.07.007  1
2013 Lewis NE, Liu X, Li Y, Nagarajan H, Yerganian G, O'Brien E, Bordbar A, Roth AM, Rosenbloom J, Bian C, Xie M, Chen W, Li N, Baycin-Hizal D, Latif H, ... ... Betenbaugh MJ, et al. Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nature Biotechnology. 31: 759-65. PMID 23873082 DOI: 10.1038/Nbt.2624  1
2013 Gramlich PA, Remington MP, Amin J, Betenbaugh MJ, Fishman PS. Tat-tetanus toxin fragment C: a novel protein delivery vector and its use with photochemical internalization. Journal of Drug Targeting. 21: 662-74. PMID 23697582 DOI: 10.3109/1061186X.2013.796954  1
2013 Xiao S, White JF, Betenbaugh MJ, Grisshammer R, Shiloach J. Transient and stable expression of the neurotensin receptor NTS1: a comparison of the baculovirus-insect cell and the T-REx-293 expression systems. Plos One. 8: e63679. PMID 23696845 DOI: 10.1371/Journal.Pone.0063679  1
2013 Kildegaard HF, Baycin-Hizal D, Lewis NE, Betenbaugh MJ. The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology. Current Opinion in Biotechnology. 24: 1102-7. PMID 23523260 DOI: 10.1016/J.Copbio.2013.02.007  1
2013 Druz A, Son YJ, Betenbaugh M, Shiloach J. Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells. Metabolic Engineering. 16: 87-94. PMID 23376592 DOI: 10.1016/J.Ymben.2012.12.004  1
2013 Druz A, Chen YC, Guha R, Betenbaugh M, Martin SE, Shiloach J. Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. Rna Biology. 10: 287-300. PMID 23353574 DOI: 10.4161/Rna.23339  1
2013 Bennun SV, Yarema KJ, Betenbaugh MJ, Krambeck FJ. Integration of the transcriptome and glycome for identification of glycan cell signatures. Plos Computational Biology. 9: e1002813. PMID 23326219 DOI: 10.1371/Journal.Pcbi.1002813  1
2013 Wan M, Faruq J, Rosenberg JN, Xia J, Oyler GA, Betenbaugh MJ. Achieving high throughput sequencing of a cDNA library utilizing an alternative protocol for the bench top next-generation sequencing system. Journal of Microbiological Methods. 92: 122-6. PMID 23127394 DOI: 10.1016/J.Mimet.2012.10.010  1
2013 Bennun SV, Hizal DB, Ranzinger R, Betenbaugh MJ. Towards Integrative Glycoinformatics for Glycan Based Biomarker Cancer Research and Discovery Journal of Glycobiology. 2013: 1-8. DOI: 10.4172/2168-958X.S1-004  0.4
2012 Ohsfeldt E, Huang SH, Baycin-Hizal D, Kristoffersen L, Le TM, Li E, Hristova K, Betenbaugh MJ. Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines. Biotechnology and Applied Biochemistry. 59: 155-62. PMID 23586824 DOI: 10.1002/Bab.1000  1
2012 Baycin-Hizal D, Tabb DL, Chaerkady R, Chen L, Lewis NE, Nagarajan H, Sarkaria V, Kumar A, Wolozny D, Colao J, Jacobson E, Tian Y, O'Meally RN, Krag SS, Cole RN, ... ... Betenbaugh M, et al. Proteomic analysis of Chinese hamster ovary cells. Journal of Proteome Research. 11: 5265-76. PMID 22971049 DOI: 10.1021/Pr300476W  1
2012 Druz A, Betenbaugh M, Shiloach J. Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation. Nucleic Acids Research. 40: 7291-302. PMID 22638581 DOI: 10.1093/Nar/Gks452  1
2012 Wan MX, Wang RM, Xia JL, Rosenberg JN, Nie ZY, Kobayashi N, Oyler GA, Betenbaugh MJ. Physiological evaluation of a new Chlorella sorokiniana isolate for its biomass production and lipid accumulation in photoautotrophic and heterotrophic cultures. Biotechnology and Bioengineering. 109: 1958-64. PMID 22354808 DOI: 10.1002/Bit.24477  1
2012 Majors BS, Chiang GG, Pederson NE, Betenbaugh MJ. Directed evolution of mammalian anti-apoptosis proteins by somatic hypermutation. Protein Engineering, Design & Selection : Peds. 25: 27-38. PMID 22160868 DOI: 10.1093/Protein/Gzr052  1
2012 Hammond S, Kaplarevic M, Borth N, Betenbaugh MJ, Lee KH. Chinese hamster genome database: an online resource for the CHO community at www.CHOgenome.org. Biotechnology and Bioengineering. 109: 1353-6. PMID 22105744 DOI: 10.1002/Bit.24374  1
2012 Dorai H, Corisdeo S, Ellis D, Kinney C, Chomo M, Hawley-Nelson P, Moore G, Betenbaugh MJ, Ganguly S. Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins. Biotechnology and Bioengineering. 109: 1016-30. PMID 22068683 DOI: 10.1002/Bit.24367  1
2012 Zustiak MP, Dorai H, Betenbaugh MJ, Sauerwald TM. Controlling apoptosis to optimize yields of proteins from mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 801: 111-23. PMID 21987250 DOI: 10.1007/978-1-61779-352-3_8  1
2011 Granell AE, Palter KB, Akan I, Aich U, Yarema KJ, Betenbaugh MJ, Thornhill WB, Recio-Pinto E. DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons. Acs Chemical Biology. 6: 1287-95. PMID 21919466 DOI: 10.1021/Cb200238K  1
2011 Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, ... ... Betenbaugh MJ, et al. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nature Biotechnology. 29: 735-41. PMID 21804562 DOI: 10.1038/Nbt.1932  1
2011 Wan M, Liu P, Xia J, Rosenberg JN, Oyler GA, Betenbaugh MJ, Nie Z, Qiu G. The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana. Applied Microbiology and Biotechnology. 91: 835-44. PMID 21698379 DOI: 10.1007/S00253-011-3399-8  1
2011 Baycin-Hizal D, Tian Y, Akan I, Jacobson E, Clark D, Wu A, Jampol R, Palter K, Betenbaugh M, Zhang H. GlycoFish: a database of zebrafish N-linked glycoproteins identified using SPEG method coupled with LC/MS. Analytical Chemistry. 83: 5296-303. PMID 21591763 DOI: 10.1021/Ac200726Q  1
2011 Hayashi T, Lewis A, Hayashi E, Betenbaugh MJ, Su TP. Antigen retrieval to improve the immunocytochemistry detection of sigma-1 receptors and ER chaperones. Histochemistry and Cell Biology. 135: 627-37. PMID 21573736 DOI: 10.1007/S00418-011-0811-5  1
2011 Baycin-Hizal D, Tian Y, Akan I, Jacobson E, Clark D, Chu J, Palter K, Zhang H, Betenbaugh MJ. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Journal of Proteome Research. 10: 2777-84. PMID 21480662 DOI: 10.1021/Pr200004T  1
2011 Wan M, Rosenberg JN, Faruq J, Betenbaugh MJ, Xia J. An improved colony PCR procedure for genetic screening of Chlorella and related microalgae. Biotechnology Letters. 33: 1615-9. PMID 21431847 DOI: 10.1007/S10529-011-0596-6  1
2011 Gillmeister MP, Betenbaugh MJ, Fishman PS. Cellular trafficking and photochemical internalization of cell penetrating peptide linked cargo proteins: a dual fluorescent labeling study. Bioconjugate Chemistry. 22: 556-66. PMID 21405111 DOI: 10.1021/Bc900445G  1
2011 Druz A, Chu C, Majors B, Santuary R, Betenbaugh M, Shiloach J. A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells. Biotechnology and Bioengineering. 108: 1651-61. PMID 21337326 DOI: 10.1002/Bit.23092  1
2011 Rosenberg JN, Mathias A, Korth K, Betenbaugh MJ, Oyler GA. Microalgal biomass production and carbon dioxide sequestration from an integrated ethanol biorefinery in Iowa: A technical appraisal and economic feasibility evaluation Biomass and Bioenergy. 35: 3865-3876. DOI: 10.1016/J.Biombioe.2011.05.014  1
2011 Hizal DB, Ohsfeldt E, Mai S, Betenbaugh MJ. Membrane Protein Expression in Mammalian Cells Production of Membrane Proteins: Strategies For Expression and Isolation. 139-165. DOI: 10.1002/9783527634521.ch5  1
2010 Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ. Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines. Biotechnology Progress. 26: 1367-81. PMID 20945491 DOI: 10.1002/Btpr.426  1
2010 Chu C, Lugovtsev V, Lewis A, Betenbaugh M, Shiloach J. Production and antigenic properties of influenza virus from suspension MDCK-siat7e cells in a bench-scale bioreactor. Vaccine. 28: 7193-201. PMID 20800699 DOI: 10.1016/J.Vaccine.2010.08.059  0.56
2010 Jones MB, Chu CH, Pendleton JC, Betenbaugh MJ, Shiloach J, Baljinnyam B, Rubin JS, Shamblott MJ. Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells and Development. 19: 1923-35. PMID 20367282 DOI: 10.1089/Scd.2009.0326  1
2010 Jones MB, Tomiya N, Betenbaugh MJ, Krag SS. Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells. Biochemical and Biophysical Research Communications. 395: 36-41. PMID 20331963 DOI: 10.1016/J.Bbrc.2010.03.117  1
2010 Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS. Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment. Journal of Biotechnology. 145: 143-59. PMID 19770009 DOI: 10.1016/J.Jbiotec.2009.09.008  1
2009 Chu C, Lugovtsev V, Golding H, Betenbaugh M, Shiloach J. Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production. Proceedings of the National Academy of Sciences of the United States of America. 106: 14802-7. PMID 19706449 DOI: 10.1073/Pnas.0905912106  0.56
2009 Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells. Biotechnology Progress. 25: 1161-8. PMID 19551877 DOI: 10.1002/Btpr.192  1
2009 Krambeck FJ, Bennun SV, Narang S, Choi S, Yarema KJ, Betenbaugh MJ. A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology. 19: 1163-75. PMID 19506293 DOI: 10.1093/Glycob/Cwp081  1
2009 Gillmeister MP, Tomiya N, Jacobia SJ, Lee YC, Gorfien SF, Betenbaugh MJ. An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: application to monitor glycan modulation by medium conditions. Glycoconjugate Journal. 26: 1135-49. PMID 19412663 DOI: 10.1007/S10719-009-9235-Z  1
2009 O'Connor S, Li E, Majors BS, He L, Placone J, Baycin D, Betenbaugh MJ, Hristova K. Increased expression of the integral membrane protein ErbB2 in Chinese hamster ovary cells expressing the anti-apoptotic gene Bcl-xL. Protein Expression and Purification. 67: 41-7. PMID 19376231 DOI: 10.1016/J.Pep.2009.04.007  1
2009 Majors BS, Chiang GG, Betenbaugh MJ. Protein and genome evolution in Mammalian cells for biotechnology applications. Molecular Biotechnology. 42: 216-23. PMID 19367473 DOI: 10.1007/S12033-009-9156-X  1
2009 Jones MB, Rosenberg JN, Betenbaugh MJ, Krag SS. Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life. Biochimica Et Biophysica Acta. 1790: 485-94. PMID 19348869 DOI: 10.1016/J.Bbagen.2009.03.030  1
2009 Dorai H, Kyung YS, Ellis D, Kinney C, Lin C, Jan D, Moore G, Betenbaugh MJ. Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture. Biotechnology and Bioengineering. 103: 592-608. PMID 19241388 DOI: 10.1002/Bit.22269  1
2009 Nivitchanyong T, Tsai YC, Betenbaugh MJ, Oyler GA. An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering. Virus Research. 141: 1-12. PMID 19200810 DOI: 10.1016/J.Virusres.2008.12.019  1
2008 Majors BS, Arden N, Oyler GA, Chiang GG, Pederson NE, Betenbaugh MJ. E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells. Journal of Biotechnology. 138: 103-6. PMID 18778741 DOI: 10.1016/J.Jbiotec.2008.08.003  1
2008 Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-x(L). Biotechnology and Bioengineering. 101: 567-78. PMID 18727128 DOI: 10.1002/Bit.21917  1
2008 Rosenberg JN, Oyler GA, Wilkinson L, Betenbaugh MJ. A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution. Current Opinion in Biotechnology. 19: 430-6. PMID 18725295 DOI: 10.1016/J.Copbio.2008.07.008  1
2008 Zustiak MP, Pollack JK, Marten MR, Betenbaugh MJ. Feast or famine: autophagy control and engineering in eukaryotic cell culture. Current Opinion in Biotechnology. 19: 518-26. PMID 18725292 DOI: 10.1016/J.Copbio.2008.07.007  1
2008 Jaluria P, Chu C, Betenbaugh M, Shiloach J. Cells by design: a mini-review of targeting cell engineering using DNA microarrays. Molecular Biotechnology. 39: 105-11. PMID 18327555 DOI: 10.1007/S12033-008-9048-5  1
2008 Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J. Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates. Biotechnology and Bioengineering. 99: 1443-52. PMID 18023050 DOI: 10.1002/Bit.21707  1
2008 Hancock K, Narang S, Pattabhi S, Yushak ML, Khan A, Lin SC, Plemons R, Betenbaugh MJ, Tsang VC. False positive reactivity of recombinant, diagnostic, glycoproteins produced in High Five insect cells: effect of glycosylation. Journal of Immunological Methods. 330: 130-6. PMID 17868684 DOI: 10.1016/J.Jim.2007.08.002  1
2007 Jaluria P, Betenbaugh M, Konstantopoulos K, Shiloach J. Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. Bmc Biotechnology. 7: 71. PMID 17945021 DOI: 10.1186/1472-6750-7-71  1
2007 Majors BS, Betenbaugh MJ, Chiang GG. Links between metabolism and apoptosis in mammalian cells: applications for anti-apoptosis engineering. Metabolic Engineering. 9: 317-26. PMID 17611135 DOI: 10.1016/J.Ymben.2007.05.003  1
2007 Nivitchanyong T, Martinez A, Ishaque A, Murphy JE, Konstantinov K, Betenbaugh MJ, Thrift J. Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture. Biotechnology and Bioengineering. 98: 825-41. PMID 17514750 DOI: 10.1002/Bit.21479  1
2007 Arden N, Ahn SH, Vaz W, Rhodes M, Hancock C, Abitorabi MA, Betenbaugh MJ. Chemical caspase inhibitors enhance cell culture viabilities and protein titer. Biotechnology Progress. 23: 506-11. PMID 17381129 DOI: 10.1021/Bp060222M  1
2007 Jaluria P, Konstantopoulos K, Betenbaugh M, Shiloach J. A perspective on microarrays: current applications, pitfalls, and potential uses. Microbial Cell Factories. 6: 4. PMID 17254338 DOI: 10.1186/1475-2859-6-4  1
2007 Jaluria P, Betenbaugh M, Konstantopoulos K, Frank B, Shiloach J. Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells. Metabolic Engineering. 9: 241-51. PMID 17240181 DOI: 10.1016/J.Ymben.2006.12.001  1
2007 Arden N, Majors BS, Ahn SH, Oyler G, Betenbaugh MJ. Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures. Biotechnology and Bioengineering. 97: 601-14. PMID 17149774 DOI: 10.1002/Bit.21254  1
2007 Figueroa B, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ. Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells. Biotechnology and Bioengineering. 97: 877-92. PMID 17099908 DOI: 10.1002/Bit.21222  1
2006 Arden N, Betenbaugh MJ. Regulating apoptosis in mammalian cell cultures. Cytotechnology. 50: 77-92. PMID 19003072 DOI: 10.1007/S10616-006-9008-5  1
2006 Tomiya N, Narang S, Park J, Abdul-Rahman B, Choi O, Singh S, Hiratake J, Sakata K, Betenbaugh MJ, Palter KB, Lee YC. Purification, characterization, and cloning of a Spodoptera frugiperda Sf9 beta-N-acetylhexosaminidase that hydrolyzes terminal N-acetylglucosamine on the N-glycan core. The Journal of Biological Chemistry. 281: 19545-60. PMID 16684772 DOI: 10.1074/Jbc.M603312200  1
2006 Sauerwald TM, Figueroa B, Hardwick JM, Oyler GA, Betenbaugh MJ. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnology and Bioengineering. 94: 362-72. PMID 16598795 DOI: 10.1002/Bit.20874  1
2006 Viswanathan K, Tomiya N, Park J, Singh S, Lee YC, Palter K, Betenbaugh MJ. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. The Journal of Biological Chemistry. 281: 15929-40. PMID 16537535 DOI: 10.1074/Jbc.M512186200  1
2005 Krambeck FJ, Betenbaugh MJ. A mathematical model of N-linked glycosylation. Biotechnology and Bioengineering. 92: 711-28. PMID 16247773 DOI: 10.1002/Bit.20645  1
2005 Jones J, Krag SS, Betenbaugh MJ. Controlling N-linked glycan site occupancy. Biochimica Et Biophysica Acta. 1726: 121-37. PMID 16126345 DOI: 10.1016/J.Bbagen.2005.07.003  1
2005 Kim YK, Shin HS, Tomiya N, Lee YC, Betenbaugh MJ, Cha HJ. Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells. Biotechnology and Bioengineering. 92: 452-61. PMID 16025538 DOI: 10.1002/Bit.20605  1
2005 Jones J, Nivitchanyong T, Giblin C, Ciccarone V, Judd D, Gorfien S, Krag SS, Betenbaugh MJ. Optimization of tetracycline-responsive recombinant protein production and effect on cell growth and ER stress in mammalian cells. Biotechnology and Bioengineering. 91: 722-32. PMID 15981277 DOI: 10.1002/Bit.20566  1
2005 Viswanathan K, Narang S, Hinderlich S, Lee YC, Betenbaugh MJ. Engineering intracellular CMP-sialic acid metabolism into insect cells and methods to enhance its generation. Biochemistry. 44: 7526-34. PMID 15895995 DOI: 10.1021/Bi047477Y  1
2005 Jones J, Viswanathan K, Krag SS, Betenbaugh MJ. Polyprenyl lipid synthesis in mammalian cells expressing human cis-prenyl transferase. Biochemical and Biophysical Research Communications. 331: 379-83. PMID 15850770 DOI: 10.1016/J.Bbrc.2005.03.181  1
2004 Tomiya N, Narang S, Lee YC, Betenbaugh MJ. Comparing N-glycan processing in mammalian cell lines to native and engineered lepidopteran insect cell lines. Glycoconjugate Journal. 21: 343-60. PMID 15514482 DOI: 10.1023/B:Glyc.0000046275.28315.87  1
2004 Betenbaugh MJ, Tomiya N, Narang S, Hsu JT, Lee YC. Biosynthesis of human-type N-glycans in heterologous systems. Current Opinion in Structural Biology. 14: 601-6. PMID 15465322 DOI: 10.1016/J.Sbi.2004.09.001  1
2004 Sundaram AK, Pitts L, Muhammad K, Wu J, Betenbaugh M, Woodard RW, Vann WF. Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni. The Biochemical Journal. 383: 83-9. PMID 15200387 DOI: 10.1042/Bj20040218  1
2004 Arden N, Betenbaugh MJ. Life and death in mammalian cell culture: strategies for apoptosis inhibition. Trends in Biotechnology. 22: 174-80. PMID 15038922 DOI: 10.1016/J.Tibtech.2004.02.004  1
2004 Figueroa B, Chen S, Oyler GA, Hardwick JM, Betenbaugh MJ. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions. Biotechnology and Bioengineering. 85: 589-600. PMID 14966800 DOI: 10.1002/Bit.10913  1
2003 Viswanathan K, Lawrence S, Hinderlich S, Yarema KJ, Lee YC, Betenbaugh MJ. Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them. Biochemistry. 42: 15215-25. PMID 14690432 DOI: 10.1021/Bi034994S  1
2003 Figueroa B, Sauerwald TM, Oyler GA, Hardwick JM, Betenbaugh MJ. A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures. Metabolic Engineering. 5: 230-45. PMID 14642351 DOI: 10.1016/S1096-7176(03)00044-2  1
2003 Tomiya N, Betenbaugh MJ, Lee YC. Humanization of lepidopteran insect-cell-produced glycoproteins. Accounts of Chemical Research. 36: 613-20. PMID 12924958 DOI: 10.1021/Ar020202V  1
2003 Pfister BJ, Weihs TP, Betenbaugh M, Bao G. An in vitro uniaxial stretch model for axonal injury. Annals of Biomedical Engineering. 31: 589-98. PMID 12757202 DOI: 10.1114/1.1566445  1
2003 Choi O, Tomiya N, Kim JH, Slavicek JM, Betenbaugh MJ, Lee YC. N-glycan structures of human transferrin produced by Lymantria dispar (gypsy moth) cells using the LdMNPV expression system. Glycobiology. 13: 539-48. PMID 12672704 DOI: 10.1093/Glycob/Cwg071  1
2003 Tomiya N, Howe D, Aumiller JJ, Pathak M, Park J, Palter KB, Jarvis DL, Betenbaugh MJ, Lee YC. Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian [beta]-1,4-galactosyltransferase and [beta]-1,2-N-acetylglucosaminyltransferase II. Glycobiology. 13: 23-34. PMID 12634321 DOI: 10.1093/Glycob/Cwg012  1
2003 Sauerwald TM, Oyler GA, Betenbaugh MJ. Study of caspase inhibitors for limiting death in mammalian cell culture. Biotechnology and Bioengineering. 81: 329-40. PMID 12474256 DOI: 10.1002/Bit.10473  1
2002 Fussenegger M, Betenbaugh MJ. Metabolic engineering II. Eukaryotic systems. Biotechnology and Bioengineering. 79: 509-31. PMID 12209823 DOI: 10.1002/Bit.10405  1
2002 Kim K, Lawrence SM, Park J, Pitts L, Vann WF, Betenbaugh MJ, Palter KB. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology. 12: 73-83. PMID 11886840 DOI: 10.1093/Glycob/12.2.73  1
2002 Sauerwald TM, Betenbaugh MJ, Oyler GA. Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants. Biotechnology and Bioengineering. 77: 704-16. PMID 11807766 DOI: 10.1002/Bit.10154  1
2001 Lawrence SM, Huddleston KA, Tomiya N, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ. Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells. Glycoconjugate Journal. 18: 205-13. PMID 11602804 DOI: 10.1023/A:1012452705349  1
2001 Tomiya N, Ailor E, Lawrence SM, Betenbaugh MJ, Lee YC. Determination of nucleotides and sugar nucleotides involved in protein glycosylation by high-performance anion-exchange chromatography: sugar nucleotide contents in cultured insect cells and mammalian cells. Analytical Biochemistry. 293: 129-37. PMID 11373089 DOI: 10.1006/Abio.2001.5091  1
2001 Figueroa B, Sauerwald TM, Mastrangelo AJ, Hardwick JM, Betenbaugh MJ. Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults. Biotechnology and Bioengineering. 73: 211-22. PMID 11257603 DOI: 10.1002/Bit.1053  1
2000 LeDuc PR, Whiteley EM, Bao G, Betenbaugh MJ. Investigating the secretory pathway of the baculovirus-insect cell system using a secretory green fluorescent protein Biotechnology Progress. 16: 716-723. PMID 11027162 DOI: 10.1021/Bp0001112  1
2000 Ailor E, Takahashi N, Tsukamoto Y, Masuda K, Rahman BA, Jarvis DL, Lee YC, Betenbaugh MJ. N-glycan patterns of human transferrin produced in Trichoplusia ni insect cells: Effects of mammalian galactosyltransferase Glycobiology. 10: 837-847. PMID 10929010 DOI: 10.1093/Glycob/10.8.837  1
2000 Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ. Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability. The Journal of Biological Chemistry. 275: 17869-77. PMID 10749855 DOI: 10.1074/Jbc.M000217200  1
2000 Mastrangelo AJ, Hardwick JM, Zou S, Betenbaugh MJ. Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults. Biotechnology and Bioengineering. 67: 555-64. PMID 10649230 DOI: 10.1002/(Sici)1097-0290(20000305)67:5<555::Aid-Bit6>3.0.Co;2-T  1
2000 Mastrangelo AJ, Hardwick JM, Bex F, Betenbaugh MJ. Part I. Bcl-2 and Bcl-x(L) limit apoptosis upon infection with alphavirus vectors. Biotechnology and Bioengineering. 67: 544-54. PMID 10649229 DOI: 10.1002/(SICI)1097-0290(20000305)67:5<544::AID-BIT5>3.0.CO;2-#  1
1999 Tate CG, Whiteley E, Betenbaugh MJ. Molecular chaperones improve functional expression of the serotonin (5-hydroxytryptamine) transporter in insect cells Biochemical Society Transactions. 27: 932-936. PMID 10830131 DOI: 10.1042/Bst0270932  1
1999 Mastrangelo AJ, Zou S, Hardwick JM, Betenbaugh MJ. Antiapoptosis chemicals prolong productive lifetimes of mammalian cells upon Sindbis virus vector infection. Biotechnology and Bioengineering. 65: 298-305. PMID 10486128 DOI: 10.1002/(Sici)1097-0290(19991105)65:3<298::Aid-Bit7>3.0.Co;2-S  1
1999 Tate CG, Whiteley E, Betenbaugh MJ. Molecular chaperones stimulate the functional expression of the cocaine- sensitive serotonin transporter Journal of Biological Chemistry. 274: 17551-17558. PMID 10364189 DOI: 10.1074/Jbc.274.25.17551  1
1999 Ailor E, Betenbaugh MJ. Modifying secretion and post-translational processing in insect cells Current Opinion in Biotechnology. 10: 142-145. PMID 10209136 DOI: 10.1016/S0958-1669(99)80024-X  1
1999 Ailor E, Pathmanathan J, Jongbloed JDH, Betenbaugh MJ. A bacterial signal peptidase enhances processing of a recombinant single chain antibody fragment in insect cells Biochemical and Biophysical Research Communications. 255: 444-450. PMID 10049728 DOI: 10.1006/Bbrc.1999.0233  1
1998 Ailor E, Betenbaugh MJ. Overexpression of a cytosolic chaperone to improve solubility and secretion of a recombinant IgG protein in insect cells Biotechnology and Bioengineering. 58: 196-203. PMID 10191390 DOI: 10.1002/(Sici)1097-0290(19980420)58:2/3<196::Aid-Bit12>3.0.Co;2-B  1
1998 Tsai AM, Van Zanten JH, Betenbaugh MJ. II. Electrostatic effect in the aggregation of heat-denatured RNase A and implications for protein additive design Biotechnology and Bioengineering. 59: 281-285. PMID 10099338 DOI: 10.1002/(Sici)1097-0290(19980805)59:3<281::Aid-Bit3>3.0.Co;2-7  1
1998 Tsai AM, Van Zanten JH, Betenbaugh MJ. I. Study of protein aggregation due to heat denaturation: A structural approach using circular dichroism spectroscopy, nuclear magnetic resonance, and static light scattering Biotechnology and Bioengineering. 59: 273-280. PMID 10099337 DOI: 10.1002/(Sici)1097-0290(19980805)59:3<273::Aid-Bit2>3.0.Co;2-8  1
1998 Mastrangelo AJ, Betenbaugh MJ. Overcoming apoptosis: New methods for improving protein-expression systems Trends in Biotechnology. 16: 88-95. PMID 9487737 DOI: 10.1016/S0167-7799(97)01159-1  1
1997 Whiteley EM, Hsu TA, Betenbaugh MJ. Thioredoxin domain non-equivalence and anti-chaperone activity of protein disulfide isomerase mutants in vivo Journal of Biological Chemistry. 272: 22556-22563. PMID 9278409 DOI: 10.1074/Jbc.272.36.22556  1
1997 Hsu TA, Takahashi N, Tsukamoto Y, Kato K, Shimada I, Masuda K, Whiteley EM, Fan JQ, Lee YC, Betenbaugh MJ. Differential N-glycan patterns of secreted and intracellular IgG produced in Trichoplusia ni cells. The Journal of Biological Chemistry. 272: 9062-70. PMID 9083032 DOI: 10.1074/Jbc.272.14.9062  1
1997 Hsu TA, Betenbaugh MJ. Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from trichoplusia ni insect cells Biotechnology Progress. 13: 96-104. PMID 9041711 DOI: 10.1021/Bp960088D  1
1997 Whiteley EM, Hsu TA, Betenbaugh MJ. Modeling assembly, aggregation, and chaperoning of immunoglobulin G production in insect cells Biotechnology and Bioengineering. 56: 106-116. DOI: 10.1002/(Sici)1097-0290(19971005)56:1<106::Aid-Bit12>3.0.Co;2-I  1
1997 LeDuc PR, Betenbaugh MJ. Implementation of a pharmocokinetic approach to a baculovirus system for analytic solutions to virus and cell interactions American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 36: 169-170.  1
1996 Hsu TA, Watson S, Eiden JJ, Betenbaugh MJ. Rescue of immunoglobulins from insolubility is facilitated by PDI in the baculovirus expression system Protein Expression and Purification. 7: 281-288. PMID 8860653 DOI: 10.1006/Prep.1996.0040  1
1996 Betenbaugh MJ, Ailor E, Whiteley E, Hinderliter P, Hsu TA. Chaperone and foldase coexpression in the baculovirus-insect cell expression system Cytotechnology. 20: 149-159. DOI: 10.1007/Bf00350396  1
1996 Mastrangelo AJ, Marie Hardwick J, Betenbaugh MJ. Bcl-2 inhibits apoptosis and extends recombinant protein production in cells infected with Sindbis viral vectors Cytotechnology. 22: 169-178.  1
1995 Betenbaugh M, Yu M, Kuehl K, White J, Pennock D, Spik K, Schmaljohn C. Nucleocapsid- and virus-like particles assemble in cells infected with recombinant baculoviruses or vaccinia viruses expressing the M and the S segments of Hantaan virus. Virus Research. 38: 111-24. PMID 8578853 DOI: 10.1016/0168-1702(95)00053-S  1
1995 Mastrangelo AJ, Betenbaugh MJ. Implications and applications of apoptosis in cell culture Current Opinion in Biotechnology. 6: 198-202. PMID 7734748 DOI: 10.1016/0958-1669(95)80032-8  1
1995 Tsai AM, Betenbaugh MJ, Shiloach J. The kinetics of RCC1 inclusion body formation in Escherichia coli Biotechnology and Bioengineering. 48: 715-718. DOI: 10.1002/Bit.260480620  1
1994 Hsu TA, Eiden JJ, Betenbaugh MJ. Engineering the assembly pathway of the baculovirus-insect cell expression system Annals of the New York Academy of Sciences. 721: 208-217. PMID 8010671 DOI: 10.1111/j.1749-6632.1994.tb47393.x  1
1994 Hsu TA, Eiden JJ, Bourgarel P, Meo T, Betenbaugh MJ. Effects of co-expressing chaperone BiP on functional antibody production in the baculovirus system Protein Expression and Purification. 5: 595-603. PMID 7858430 DOI: 10.1006/Prep.1994.1082  1
1993 Juarbeosorio LG, Gorziglia M, Betenbaugh MJ. Recovery and Characterization of a Rotavirus Outer Capsid Protein Expressed in a Recombinant Insect Cell System Protein Expression and Purification. 4: 232-239. PMID 8390880 DOI: 10.1006/Prep.1993.1030  1
1993 Lindsay DA, Vonderfecht SL, Betenbaugh MJ, Eiden JJ. Baculovirus expression of gene 6 of the IDIR strain of group B rotavirus (GBR): Coding assignment of the major inner capsid protein Virology. 193: 367-375. PMID 8382401 DOI: 10.1006/Viro.1993.1133  1
1993 Lindsay DA, Vonderfecht SS, Willoughby R, Betenbaugh MJ, Eiden JJ. Identification and expression of the outer capsid protein (VP4) of the IDIR strain of group B rotavirus Virology. 194: 724-733. PMID 7684874 DOI: 10.1006/Viro.1993.1313  1
1992 Betenbaugh MJ, Lindsay DA, Juarbe-Osorio LG, Gorziglia M, Vonderfecht S, Eiden JJ. Genetically engineered viral antigens from insect cell culture Annals of the New York Academy of Sciences. 665: 210-218. PMID 1329599 DOI: 10.1111/J.1749-6632.1992.Tb42585.X  1
1992 Lindsay DA, Betenbaugh MJ. Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells Biotechnology and Bioengineering. 39: 614-618. DOI: 10.1002/Bit.260390605  1
1990 Betenbaugh MJ, Dhurjati P. Effects of promoter induction and copy number amplification on cloned gene expression and growth of recombinant cell cultures Annals of the New York Academy of Sciences. 589: 111-120. PMID 2192653 DOI: 10.1111/J.1749-6632.1990.Tb24238.X  1
1990 Betenbaugh MJ, Dhurjati P. A comparison of mathematical model predictions to experimental measurements for growth and recombinant protein production in induced cultures of Escherichia coli Biotechnology and Bioengineering. 36: 124-134. DOI: 10.1002/Bit.260360204  1
1989 Betenbaugh MJ, Beaty C, Dhurjati P. Effects of plasmid amplification and recombinant gene expression on the growth kinetics of recombinant E. coli Biotechnology and Bioengineering. 33: 1425-1436. DOI: 10.1002/Bit.260331110  1
1987 Hopkins DJ, Betenbaugh MJ, Dhurjati P. Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401. Biotechnology and Bioengineering. 29: 85-91. PMID 18561133 DOI: 10.1002/Bit.260290113  1
1987 Betenbaugh MJ, DiPasquantonio VM, Dhurjati P. Growth kinetics of Escherichia coli containing temperature-sensitive plasmid pOU140 Biotechnology and Bioengineering. 29: 1164-1172. DOI: 10.1002/Bit.260290918  1
1987 diPasquantonio VM, Betenbaugh MJ, Dhurjati P. Improvement of product yields by temperature-shifting of Escherichia coli cultures containing plasmid pOU140 Biotechnology and Bioengineering. 29: 513-519. DOI: 10.1002/Bit.260290416  1
1987 Hopkins DJ, Betenbaugh MJ, Dhurjati P. Effects of dissolved oxygen shock on the stability of recombinant Escherichia coli containing plasmid pKN401 Biotechnology and Bioengineering. 29: 85-91. DOI: 10.1002/bit.260290113  1
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