| Year |
Citation |
Score |
| 2024 |
Wible DJ, Parikh Z, Cho EJ, Chen MD, Jeter CR, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Cell Death & Disease. 15: 80. PMID 38253602 DOI: 10.1038/s41419-024-06423-0 |
0.675 |
|
| 2023 |
Wible DJ, Parikh Z, Cho EJ, Chen MD, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Biorxiv : the Preprint Server For Biology. PMID 36993747 DOI: 10.1101/2023.03.13.532495 |
0.671 |
|
| 2022 |
Carter RJ, Milani M, Beckett AJ, Liu S, Prior IA, Cohen GM, Varadarajan S. Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis. Cell Death & Disease. 13: 436. PMID 35508606 DOI: 10.1038/s41419-022-04869-8 |
0.372 |
|
| 2019 |
Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, ... ... Varadarajan S, et al. Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death & Disease. 10: 912. PMID 31801952 DOI: 10.1038/S41419-019-2150-8 |
0.394 |
|
| 2019 |
Milani M, Beckett AJ, Al-Zebeeby A, Luo X, Prior IA, Cohen GM, Varadarajan S. DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. Cell Death Discovery. 5: 117. PMID 31341643 DOI: 10.1038/S41420-019-0199-X |
0.562 |
|
| 2019 |
Yedida G, Milani M, Cohen GM, Varadarajan S. Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. Cell Death & Disease. 10: 521. PMID 31285422 DOI: 10.1038/S41419-019-1759-Y |
0.493 |
|
| 2018 |
Al-Zebeeby A, Vogler M, Milani M, Richards C, Alotibi A, Greaves G, Dyer MJS, Cohen GM, Varadarajan S. Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in haematological malignancies. Haematologica. PMID 30467206 DOI: 10.3324/Haematol.2018.204701 |
0.417 |
|
| 2018 |
Greaves G, Milani M, Butterworth M, Carter RJ, Byrne DP, Eyers PA, Luo X, Cohen GM, Varadarajan S. BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X. Cell Death and Differentiation. PMID 30185825 DOI: 10.1038/S41418-018-0183-7 |
0.556 |
|
| 2018 |
Henz K, Al-Zebeeby A, Basoglu M, Fulda S, Cohen GM, Varadarajan S, Vogler M. Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations. Biological Chemistry. PMID 29924730 DOI: 10.1515/Hsz-2018-0233 |
0.527 |
|
| 2017 |
Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S. DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. Cell Death & Disease. 8: e2552. PMID 28079887 DOI: 10.1038/Cddis.2016.485 |
0.59 |
|
| 2016 |
Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S. High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. Leukemia. PMID 26987906 DOI: 10.1038/Leu.2016.42 |
0.425 |
|
| 2016 |
Butterworth M, Pettitt A, Varadarajan S, Cohen GM. BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells. British Journal of Cancer. PMID 26954718 DOI: 10.1038/Bjc.2016.49 |
0.446 |
|
| 2015 |
Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG, Cohen GM. Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner. Oncotarget. 6: 12668-81. PMID 26059440 DOI: 10.18632/Oncotarget.3706 |
0.587 |
|
| 2015 |
Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM. The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Cell Death and Differentiation. 22: 1388-96. PMID 25656655 DOI: 10.1038/Cdd.2015.1 |
0.443 |
|
| 2013 |
Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM. Evaluation and critical assessment of putative MCL-1 inhibitors. Cell Death and Differentiation. 20: 1475-84. PMID 23832116 DOI: 10.1038/Cdd.2013.79 |
0.561 |
|
| 2013 |
Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM. Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. Neoplasia (New York, N.Y.). 15: 568-78. PMID 23633928 DOI: 10.1593/Neo.13230 |
0.564 |
|
| 2013 |
Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. Plos One. 8: e56603. PMID 23457590 DOI: 10.1371/Journal.Pone.0056603 |
0.354 |
|
| 2013 |
Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T. The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Molecular Biology of the Cell. 24: 1020-9. PMID 23389632 DOI: 10.1091/Mbc.E12-08-0575 |
0.316 |
|
| 2012 |
Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM. A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. Cell Death and Differentiation. 19: 1896-907. PMID 22955944 DOI: 10.1038/Cdd.2012.108 |
0.349 |
|
| 2010 |
Son JK, Varadarajan S, Bratton SB. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death and Differentiation. 17: 1288-301. PMID 20168333 DOI: 10.1038/Cdd.2010.9 |
0.677 |
|
| 2007 |
Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. The Embo Journal. 26: 3144-56. PMID 17557079 DOI: 10.1038/Sj.Emboj.7601745 |
0.671 |
|
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