Marc W. Kirschner - Publications

Affiliations: 
Systems Biology Harvard Medical School, Boston, MA, United States 
Area:
Cell Cycle, Cytoskeleton, Systems Biology
Website:
http://kirschner.med.harvard.edu/

252 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, ... ... Kirschner MW, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science (New York, N.Y.). 361: 290-295. PMID 30026228 DOI: 10.1126/science.aap8411  0.56
2018 Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science (New York, N.Y.). PMID 29700227 DOI: 10.1126/science.aar5780  0.44
2017 Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg. Proceedings of the National Academy of Sciences of the United States of America. 114: E10838-E10847. PMID 29183978 DOI: 10.1073/pnas.1709207114  0.84
2017 Briggs JA, Li VC, Lee S, Woolf CJ, Klein A, Kirschner MW. Mouse embryonic stem cells can differentiate via multiple paths to the same state. Elife. 6. PMID 28990928 DOI: 10.7554/eLife.26945  0.96
2017 Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, et al. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 6. PMID 28885975 DOI: 10.7554/eLife.26509  0.84
2017 Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/j.celrep.2017.06.074  0.84
2017 Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Molecular Cell. PMID 28689658 DOI: 10.1016/j.molcel.2017.06.007  0.8
2017 Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, ... ... Kirschner MW, et al. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery. PMID 28174173 DOI: 10.1158/2159-8290.CD-16-0647  0.8
2016 Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y. Structural basis for dynamic regulation of the human 26S proteasome. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791164 DOI: 10.1073/pnas.1614614113  0.8
2016 Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, ... ... Kirschner MW, et al. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165: 1440-1453. PMID 27259151 DOI: 10.1016/j.cell.2016.05.037  0.56
2016 Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, et al. Preprints for the life sciences. Science (New York, N.Y.). 352: 899-901. PMID 27199406 DOI: 10.1126/science.aaf9133  0.32
2015 Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. The Journal of Cell Biology. 211: 757-63. PMID 26598613 DOI: 10.1083/jcb.201505058  1
2015 Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM, Sasaki A, Hikosaka-Katayama T, ... ... Kirschner MW, et al. Hemichordate genomes and deuterostome origins. Nature. PMID 26580012 DOI: 10.1038/nature16150  0.56
2015 Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Developmental Cell. 35: 383-94. PMID 26555057 DOI: 10.1016/j.devcel.2015.10.010  1
2015 Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Current Biology : Cb. 25: 2663-71. PMID 26441354 DOI: 10.1016/j.cub.2015.08.047  1
2015 Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell. 161: 1187-201. PMID 26000487 DOI: 10.1016/j.cell.2015.04.044  1
2015 Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (New York, N.Y.). 348: 1250834. PMID 25859050 DOI: 10.1126/science.1250834  1
2015 Lu Y, Wang W, Kirschner MW. Specificity of the anaphase-promoting complex: a single-molecule study. Science (New York, N.Y.). 348: 1248737. PMID 25859049 DOI: 10.1126/science.1248737  1
2015 Ginzberg MB, Kafri R, Kirschner M. On being the right (cell) size Science. 348. DOI: 10.1126/science.1245075  1
2014 Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159: 844-56. PMID 25417160 DOI: 10.1016/j.cell.2014.10.032  1
2014 Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proceedings of the National Academy of Sciences of the United States of America. 111: 15768-73. PMID 25324523 DOI: 10.1073/pnas.1417518111  1
2014 Satoh N, Tagawa K, Lowe CJ, Yu JK, Kawashima T, Takahashi H, Ogasawara M, Kirschner M, Hisata K, Su YH, Gerhart J. On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates. Genesis (New York, N.Y. : 2000). 52: 925-34. PMID 25303744 DOI: 10.1002/dvg.22831  1
2014 Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ. Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. The Journal of Biological Chemistry. 289: 28942-55. PMID 25147182 DOI: 10.1074/jbc.M114.573352  1
2014 Wang W, Wu T, Kirschner MW. The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium. Elife. 3: e03083. PMID 25139956 DOI: 10.7554/eLife.03083  0.56
2014 Merbl Y, Kirschner MW. Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 77: 27.8.1-27.8.13. PMID 25081743 DOI: 10.1002/0471140864.ps2708s77  0.56
2014 Li VC, Kirschner MW. Molecular ties between the cell cycle and differentiation in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 9503-8. PMID 24979803 DOI: 10.1073/pnas.1408638111  1
2014 Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi SP, Kirschner MW. Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database. Current Biology : Cb. 24: 1467-75. PMID 24954049 DOI: 10.1016/j.cub.2014.05.044  1
2014 Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Developmental Cell. 29: 377-91. PMID 24871945 DOI: 10.1016/j.devcel.2014.04.022  1
2014 Alberts B, Kirschner MW, Tilghman S, Varmus H. Rescuing US biomedical research from its systemic flaws. Proceedings of the National Academy of Sciences of the United States of America. 111: 5773-7. PMID 24733905 DOI: 10.1073/pnas.1404402111  1
2014 Gujral TS, Peshkin L, Kirschner MW. Exploiting polypharmacology for drug target deconvolution. Proceedings of the National Academy of Sciences of the United States of America. 111: 5048-53. PMID 24707051 DOI: 10.1073/pnas.1403080111  1
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Kirschner MW, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/nature13079  1
2014 Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. Journal of the American Chemical Society. 136: 4845-8. PMID 24580054 DOI: 10.1021/ja500451w  1
2013 Kirschner M. Beyond Darwin: Evolvability and the generation of novelty Bmc Biology. 11. PMID 24228732 DOI: 10.1186/1741-7007-11-110  1
2013 Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW. Size homeostasis in adherent cells studied by synthetic phase microscopy. Proceedings of the National Academy of Sciences of the United States of America. 110: 16687-92. PMID 24065823 DOI: 10.1073/pnas.1315290110  1
2013 Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16. PMID 23972993 DOI: 10.1016/j.celrep.2013.07.031  1
2013 Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 110: E2848-53. PMID 23836640 DOI: 10.1073/pnas.1310677110  1
2013 Wang W, Kirschner MW. Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nature Cell Biology. 15: 797-806. PMID 23708001 DOI: 10.1038/ncb2755  1
2013 Gallop JL, Walrant A, Cantley LC, Kirschner MW. Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proceedings of the National Academy of Sciences of the United States of America. 110: 7193-8. PMID 23589871 DOI: 10.1073/pnas.1305286110  1
2013 Cooper KL, Oh S, Sung Y, Dasari RR, Kirschner MW, Tabin CJ. Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature. 495: 375-8. PMID 23485973 DOI: 10.1038/nature11940  1
2013 Merbl Y, Refour P, Patel H, Springer M, Kirschner MW. Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell. 152: 1160-72. PMID 23452859 DOI: 10.1016/j.cell.2013.02.007  1
2013 Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 494: 480-3. PMID 23446419 DOI: 10.1038/nature11897  1
2013 Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. The Journal of Biological Chemistry. 288: 2976-85. PMID 23184937 DOI: 10.1074/jbc.M112.430066  1
2013 Kirschner M. A perverted view of "impact" Science. 340: 1265. DOI: 10.1126/science.1240456  1
2012 Hernández AR, Klein AM, Kirschner MW. Kinetic responses of β-catenin specify the sites of Wnt control. Science (New York, N.Y.). 338: 1337-40. PMID 23138978 DOI: 10.1126/science.1228734  1
2012 Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP. Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Analytical Chemistry. 84: 9214-21. PMID 23098179 DOI: 10.1021/ac301962s  1
2012 Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, et al. Identical genomic organization of two hemichordate hox clusters. Current Biology : Cb. 22: 2053-8. PMID 23063438 DOI: 10.1016/j.cub.2012.08.052  1
2012 Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR. Direct observation of mammalian cell growth and size regulation. Nature Methods. 9: 910-2. PMID 22863882 DOI: 10.1038/nmeth.2133  1
2012 Li VC, Ballabeni A, Kirschner MW. Gap 1 phase length and mouse embryonic stem cell self-renewal. Proceedings of the National Academy of Sciences of the United States of America. 109: 12550-5. PMID 22802651 DOI: 10.1073/pnas.1206740109  1
2012 Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (New York, N.Y.). 336: 1040-4. PMID 22628656 DOI: 10.1126/science.1218595  1
2012 Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, ... Kirschner MW, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 485: 195-200. PMID 22575959 DOI: 10.1038/nature11019  1
2011 Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 19252-7. PMID 22084091 DOI: 10.1073/pnas.1116794108  1
2011 Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development (Cambridge, England). 138: 4267-77. PMID 21852393 DOI: 10.1242/dev.067900  1
2011 Yanai I, Peshkin L, Jorgensen P, Kirschner MW. Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Developmental Cell. 20: 483-96. PMID 21497761 DOI: 10.1016/j.devcel.2011.03.015  1
2011 Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW. Remodeling of the metabolome during early frog development. Plos One. 6: e16881. PMID 21347444 DOI: 10.1371/journal.pone.0016881  1
2011 Darras S, Gerhart J, Terasaki M, Kirschner M, Lowe CJ. β-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development (Cambridge, England). 138: 959-70. PMID 21303849 DOI: 10.1242/dev.059493  1
2011 Tzur A, Moore JK, Jorgensen P, Shapiro HM, Kirschner MW. Optimizing optical flow cytometry for cell volume-based sorting and analysis. Plos One. 6: e16053. PMID 21283800 DOI: 10.1371/journal.pone.0016053  1
2011 Merbl Y, Kirschner MW. Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 347-56. PMID 20865779 DOI: 10.1002/wsbm.120  1
2010 Kirschner M. Cell biology as a world view Molecular Biology of the Cell. 21: 3803. PMID 21079019  1
2010 Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes & Development. 24: 2531-42. PMID 20966048 DOI: 10.1101/gad.1984210  1
2010 Lee K, Gallop JL, Rambani K, Kirschner MW. Self-assembly of filopodia-like structures on supported lipid bilayers. Science (New York, N.Y.). 329: 1341-5. PMID 20829485 DOI: 10.1126/science.1191710  1
2010 Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes & Development. 24: 1434-47. PMID 20595234 DOI: 10.1101/gad.1925010  1
2010 Springer M, Weissman JS, Kirschner MW. A general lack of compensation for gene dosage in yeast. Molecular Systems Biology. 6: 368. PMID 20461075 DOI: 10.1038/msb.2010.19  1
2010 Godin M, Delgado FF, Son S, Grover WH, Bryan AK, Tzur A, Jorgensen P, Payer K, Grossman AD, Kirschner MW, Manalis SR. Using buoyant mass to measure the growth of single cells. Nature Methods. 7: 387-90. PMID 20383132 DOI: 10.1038/nmeth.1452  1
2010 DeLuna A, Springer M, Kirschner MW, Kishony R. Need-based up-regulation of protein levels in response to deletion of their duplicate genes. Plos Biology. 8: e1000347. PMID 20361019 DOI: 10.1371/journal.pbio.1000347  1
2010 Deibler RW, Kirschner MW. Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Molecular Cell. 37: 753-67. PMID 20347419 DOI: 10.1016/j.molcel.2010.02.023  1
2010 Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW. UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proceedings of the National Academy of Sciences of the United States of America. 107: 1355-60. PMID 20080579 DOI: 10.1073/pnas.0912802107  1
2009 Goentoro L, Shoval O, Kirschner MW, Alon U. The incoherent feedforward loop can provide fold-change detection in gene regulation. Molecular Cell. 36: 894-9. PMID 20005851 DOI: 10.1016/j.molcel.2009.11.018  1
2009 Goentoro L, Kirschner MW. Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Molecular Cell. 36: 872-84. PMID 20005849 DOI: 10.1016/j.molcel.2009.11.017  1
2009 Lebensohn AM, Kirschner MW. Activation of the WAVE complex by coincident signals controls actin assembly. Molecular Cell. 36: 512-24. PMID 19917258 DOI: 10.1016/j.molcel.2009.10.024  1
2009 Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, ... ... Kirschner MW, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 461: 614-20. PMID 19759537 DOI: 10.1038/nature08356  1
2009 Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science (New York, N.Y.). 325: 167-71. PMID 19589995 DOI: 10.1126/science.1174294  1
2009 Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell. 20: 3305-16. PMID 19477924 DOI: 10.1091/mbc.E09-01-0092  1
2009 Jorgensen P, Steen JA, Steen H, Kirschner MW. The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development (Cambridge, England). 136: 1539-48. PMID 19363155 DOI: 10.1242/dev.032425  1
2009 Singh S, Springer M, Steen J, Kirschner MW, Steen H. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. Journal of Proteome Research. 8: 2201-10. PMID 19344176 DOI: 10.1021/pr800654s  1
2009 Merbl Y, Kirschner MW. Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proceedings of the National Academy of Sciences of the United States of America. 106: 2543-8. PMID 19181856 DOI: 10.1073/pnas.0812892106  1
2008 Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. The Biological Bulletin. 214: 284-302. PMID 18574105  1
2008 Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America. 105: 6069-74. PMID 18420821 DOI: 10.1073/pnas.0709807104  1
2007 Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW. The relationship between evolutionary and physiological variation in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. 104: 16998-7003. PMID 17942680 DOI: 10.1073/pnas.0707673104  1
2007 Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. Journal of Cell Science. 120: 3565-77. PMID 17895362 DOI: 10.1242/jcs.016626  1
2007 Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. Plos Biology. 5: e221. PMID 17696648 DOI: 10.1371/journal.pbio.0050221  1
2007 Gerhart J, Kirschner M. The theory of facilitated variation. Proceedings of the National Academy of Sciences of the United States of America. 104: 8582-9. PMID 17494755 DOI: 10.1073/pnas.0701035104  1
2007 Reddy SK, Rape M, Margansky WA, Kirschner MW. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature. 446: 921-5. PMID 17443186 DOI: 10.1038/nature05734  1
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 446: 876-81. PMID 17443180 DOI: 10.1038/nature05694  1
2007 Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 128: 1119-32. PMID 17382881 DOI: 10.1016/j.cell.2006.11.053  1
2007 Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities Nature. 447: 876-881.  1
2006 Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Dorsoventral patterning in hemichordates: insights into early chordate evolution. Plos Biology. 4: e291. PMID 16933975 DOI: 10.1371/journal.pbio.0040291  1
2006 Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chemistry & Biology. 13: 443-52. PMID 16632257 DOI: 10.1016/j.chembiol.2006.02.009  1
2006 Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW. In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods in Enzymology. 406: 174-90. PMID 16472658 DOI: 10.1016/S0076-6879(06)06014-9  1
2006 Lebensohn AM, Ma L, Ho HY, Kirschner MW. Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods in Enzymology. 406: 156-73. PMID 16472657 DOI: 10.1016/S0076-6879(06)06013-7  1
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/journal.pbio.0040038  1
2006 Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell. 124: 89-103. PMID 16413484 DOI: 10.1016/j.cell.2005.10.032  1
2006 Steen H, Jebanathirajah JA, Rush J, Morrice N, Kirschner MW. Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Molecular & Cellular Proteomics : McP. 5: 172-81. PMID 16204703 DOI: 10.1074/mcp.M500135-MCP200  1
2005 Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW. Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods in Enzymology. 399: 404-14. PMID 16338372 DOI: 10.1016/S0076-6879(05)99028-9  1
2005 Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. Journal of the American Society For Mass Spectrometry. 16: 1985-99. PMID 16271296 DOI: 10.1016/j.jasms.2005.08.008  1
2005 Kwan KM, Kirschner MW. A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development (Cambridge, England). 132: 4599-610. PMID 16176947 DOI: 10.1242/dev.02041  1
2005 Gerhart J, Lowe C, Kirschner M. Hemichordates and the origin of chordates. Current Opinion in Genetics & Development. 15: 461-7. PMID 15964754 DOI: 10.1016/j.gde.2005.06.004  1
2005 Kirschner MW. The meaning of systems biology. Cell. 121: 503-4. PMID 15907462 DOI: 10.1016/j.cell.2005.05.005  1
2005 Viadiu H, Stemmann O, Kirschner MW, Walz T. Domain structure of separase and its binding to securin as determined by EM. Nature Structural & Molecular Biology. 12: 552-3. PMID 15880121 DOI: 10.1038/nsmb935  1
2005 Rankin S, Ayad NG, Kirschner MW. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Molecular Cell. 18: 185-200. PMID 15837422 DOI: 10.1016/j.molcel.2005.03.017  1
2005 Steen H, Jebanathirajah JA, Springer M, Kirschner MW. Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proceedings of the National Academy of Sciences of the United States of America. 102: 3948-53. PMID 15741271 DOI: 10.1073/pnas.0409536102  1
2005 Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Developmental Cell. 8: 435-42. PMID 15737938 DOI: 10.1016/j.devcel.2004.12.008  1
2005 Kirschner MW, Gerhart JC. The plausibility of life: Resolving Darwin's Dilemma The Plausibility of Life: Resolving Darwin's Dilemma. 1-314.  1
2004 Lowe CJ, Tagawa K, Humphreys T, Kirschner M, Gerhart J. Hemichordate embryos: procurement, culture, and basic methods. Methods in Cell Biology. 74: 171-94. PMID 15575607  1
2004 Rape M, Kirschner MW. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature. 432: 588-95. PMID 15558010 DOI: 10.1038/nature03023  1
2004 Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proceedings of the National Academy of Sciences of the United States of America. 101: 11821-6. PMID 15289600 DOI: 10.1073/pnas.0404439101  1
2004 Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118: 203-16. PMID 15260990 DOI: 10.1016/j.cell.2004.06.027  1
2004 Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nature Structural & Molecular Biology. 11: 747-55. PMID 15235593 DOI: 10.1038/nsmb796  1
2004 Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Molecular and Cellular Biology. 24: 5269-80. PMID 15169891 DOI: 10.1128/MCB.24.12.5269-5280.2004  1
2004 Gautreau A, Ho HY, Li J, Steen H, Gygi SP, Kirschner MW. Purification and architecture of the ubiquitous Wave complex. Proceedings of the National Academy of Sciences of the United States of America. 101: 4379-83. PMID 15070726 DOI: 10.1073/pnas.0400628101  1
2004 Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 428: 194-8. PMID 15014503 DOI: 10.1038/nature02381  1
2004 Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM. Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. The Journal of Cell Biology. 164: 407-16. PMID 14757753 DOI: 10.1083/jcb.200306032  1
2004 Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nature Cell Biology. 6: 129-37. PMID 14743218 DOI: 10.1038/ncb1091  1
2003 Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. Plos Biology. 1: E10. PMID 14551908 DOI: 10.1371/journal.pbio.0000010  1
2003 Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. The Embo Journal. 22: 3602-12. PMID 12853475 DOI: 10.1093/emboj/cdg350  1
2003 Gerber SA, Rush J, Stemman O, Kirschner MW, Gygi SP. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proceedings of the National Academy of Sciences of the United States of America. 100: 6940-5. PMID 12771378 DOI: 10.1073/pnas.0832254100  1
2003 Osterfield M, Kirschner MW, Flanagan JG. Graded positional information: interpretation for both fate and guidance. Cell. 113: 425-8. PMID 12757702 DOI: 10.1016/S0092-8674(03)00359-3  1
2003 Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell. 113: 101-13. PMID 12679038 DOI: 10.1016/S0092-8674(03)00232-0  1
2003 Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 3925-9. PMID 12655059 DOI: 10.1073/pnas.0330774100  1
2003 Kwan KM, Kirschner MW. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development (Cambridge, England). 130: 1961-72. PMID 12642499 DOI: 10.1242/dev.00412  1
2003 Collavin L, Kirschner MW. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development (Cambridge, England). 130: 805-16. PMID 12506010 DOI: 10.1242/dev.00306  1
2002 Castiglione F, Bernaschi M, Succi S, Heinrich R, Kirschner MW. Intracellular signal propagation in a two-dimensional autocatalytic reaction model. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 66: 031905. PMID 12366150 DOI: 10.1103/PhysRevE.66.031905  0.52
2002 Zou H, Stemman O, Anderson JS, Mann M, Kirschner MW. Anaphase specific auto-cleavage of separase. Febs Letters. 528: 246-50. PMID 12297314 DOI: 10.1016/S0014-5793(02)03238-6  1
2002 Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418: 790-3. PMID 12181570 DOI: 10.1038/nature00859  1
2002 Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. The Journal of Biological Chemistry. 277: 34727-35. PMID 12121999 DOI: 10.1074/jbc.M204989200  1
2002 Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner MW, Fontana JA. Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Research. 62: 3842-9. PMID 12097298  1
2002 Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology. 4: 509-13. PMID 12080346 DOI: 10.1038/ncb811  1
2002 Georgi AB, Stukenberg PT, Kirschner MW. Timing of events in mitosis. Current Biology : Cb. 12: 105-14. PMID 11818060 DOI: 10.1016/S0960-9822(01)00662-5  1
2001 Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW. Dual inhibition of sister chromatid separation at metaphase. Cell. 107: 715-26. PMID 11747808 DOI: 10.1016/S0092-8674(01)00603-1  1
2001 Wan Y, Liu X, Kirschner MW. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Molecular Cell. 8: 1027-39. PMID 11741538 DOI: 10.1016/S1097-2765(01)00382-3  1
2001 Davis RL, Turner DL, Evans LM, Kirschner MW. Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation. Developmental Cell. 1: 553-65. PMID 11703945 DOI: 10.1016/S1534-5807(01)00054-5  1
2001 Wan Y, Kirschner MW. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proceedings of the National Academy of Sciences of the United States of America. 98: 13066-71. PMID 11687641 DOI: 10.1073/pnas.231487598  1
2001 Pfleger CM, Lee E, Kirschner MW. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes & Development. 15: 2396-407. PMID 11562349 DOI: 10.1101/gad.918201  1
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/pnas.201393198  1
2001 Ho HY, Rohatgi R, Ma L, Kirschner MW. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proceedings of the National Academy of Sciences of the United States of America. 98: 11306-11. PMID 11553796 DOI: 10.1073/pnas.211420498  1
2001 Lee E, Salic A, Kirschner MW. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. The Journal of Cell Biology. 154: 983-93. PMID 11524435 DOI: 10.1083/jcb.200102074  1
2001 Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes & Development. 15: 1759-64. PMID 11459825 DOI: 10.1101/gad.897901  1
2001 Stukenberg PT, Kirschner MW. Pin1 acts catalytically to promote a conformational change in Cdc25. Molecular Cell. 7: 1071-83. PMID 11389853 DOI: 10.1016/S1097-2765(01)00245-3  1
2001 Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. The Journal of Biological Chemistry. 276: 26448-52. PMID 11340081 DOI: 10.1074/jbc.M103856200  1
2000 Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 28: 665-79. PMID 11163258 DOI: 10.1016/S0896-6273(00)00145-8  1
2000 Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, Takenawa T. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proceedings of the National Academy of Sciences of the United States of America. 97: 12631-6. PMID 11058146 DOI: 10.1073/pnas.190351397  1
2000 Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. The Journal of Cell Biology. 150: 1299-310. PMID 10995436 DOI: 10.1083/jcb.150.6.1299  1
2000 Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6  1
2000 Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Molecular Cell. 5: 523-32. PMID 10882137  1
2000 Pfleger CM, Kirschner MW. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes & Development. 14: 655-65. PMID 10733526  1
2000 Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nature Structural Biology. 7: 224-9. PMID 10700282 DOI: 10.1038/73338  1
2000 Davis RL, Kirschner MW. The fate of cells in the tailbud of Xenopus laevis. Development (Cambridge, England). 127: 255-67. PMID 10603344  1
1999 Kroll KL, Kirschner MW. Easy passage: germline transgenesis in frogs. Proceedings of the National Academy of Sciences of the United States of America. 96: 14189-90. PMID 10588674 DOI: 10.1073/pnas.96.25.14189  1
1999 Fang G, Yu H, Kirschner MW. Control of mitotic transitions by the anaphase-promoting complex. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1583-90. PMID 10582244 DOI: 10.1098/rstb.1999.0502  1
1999 Odde DJ, Ma L, Briggs AH, DeMarco A, Kirschner MW. Microtubule bending and breaking in living fibroblast cells. Journal of Cell Science. 112: 3283-8. PMID 10504333  1
1999 Kirschner MW, Marchesi V, Baum H. E-Publication proposal [3] (multiple letters) Science. 285: 1013-1014. PMID 10475840  1
1999 Kirschner MW. E-publication proposal. Science (New York, N.Y.). 285: 1013. PMID 10475839  1
1999 Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science (New York, N.Y.). 285: 418-22. PMID 10411507 DOI: 10.1126/science.285.5426.418  1
1999 Zhou BB, Kirschner MW. Quantitative measurement of the catastrophe rate of dynamic microtubules. Cell Motility and the Cytoskeleton. 43: 43-51. PMID 10340702 DOI: 10.1002/(SICI)1097-0169(1999)43:1<43::AID-CM5>3.0.CO;2-A  1
1999 Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97: 221-31. PMID 10219243  1
1999 Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. Current Biology : Cb. 9: 174-85. PMID 10074426 DOI: 10.1016/S0960-9822(99)80087-6  1
1999 Philpott A, Tsai L, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. Developmental Biology. 207: 119-32. PMID 10049569 DOI: 10.1006/dbio.1998.9146  1
1998 Ma L, Rohatgi R, Kirschner MW. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proceedings of the National Academy of Sciences of the United States of America. 95: 15362-7. PMID 9860974 DOI: 10.1073/pnas.95.26.15362  1
1998 Sif S, Stukenberg PT, Kirschner MW, Kingston RE. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes & Development. 12: 2842-51. PMID 9744861  1
1998 Mead PE, Zhou Y, Lustig KD, Huber TL, Kirschner MW, Zon LI. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 11251-6. PMID 9736722 DOI: 10.1073/pnas.95.19.11251  1
1998 Fang G, Yu H, Kirschner MW. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Molecular Cell. 2: 163-71. PMID 9734353  1
1998 Kroll KL, Salic AN, Evans LM, Kirschner MW. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development (Cambridge, England). 125: 3247-58. PMID 9671596  1
1998 Fang G, Yu H, Kirschner MW. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Development. 12: 1871-83. PMID 9637688  1
1998 McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 93: 1043-53. PMID 9635433 DOI: 10.1016/S0092-8674(00)81209-X  1
1998 Zhou BB, Li H, Yuan J, Kirschner MW. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6785-90. PMID 9618490 DOI: 10.1073/pnas.95.12.6785  1
1998 Shen M, Stukenberg PT, Kirschner MW, Lu KP. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes & Development. 12: 706-20. PMID 9499405  1
1998 Ma L, Cantley LC, Janmey PA, Kirschner MW. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. The Journal of Cell Biology. 140: 1125-36. PMID 9490725 DOI: 10.1083/jcb.140.5.1125  1
1998 Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 279: 1219-22. PMID 9469815 DOI: 10.1126/science.279.5354.1219  1
1997 Yamashita YM, Peters JM, King RW, Höög C, Kirschner MW, Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. BIME joins the destruction team. Trends in Cell Biology. 7: 49. PMID 17708905 DOI: 10.1016/S0962-8924(97)82669-4  0.96
1997 Salic AN, Kroll KL, Evans LM, Kirschner MW. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development (Cambridge, England). 124: 4739-48. PMID 9428410  1
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/science.278.5345.1957  1
1997 Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW, Yuan J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. The Journal of Biological Chemistry. 272: 29449-53. PMID 9368003 DOI: 10.1074/jbc.272.47.29449  1
1997 Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (New York, N.Y.). 278: 294-8. PMID 9323209 DOI: 10.1126/science.278.5336.294  1
1997 Yew PR, Kirschner MW. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science (New York, N.Y.). 277: 1672-6. PMID 9287222 DOI: 10.1126/science.277.5332.1672  1
1997 King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW. Expression cloning in the test tube. Science (New York, N.Y.). 277: 973-4. PMID 9281074 DOI: 10.1126/science.277.5328.973  1
1997 Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods in Enzymology. 283: 83-99. PMID 9251013 DOI: 10.1016/S0076-6879(97)83009-1  1
1997 Rankin S, Kirschner MW. The surface contraction waves of Xenopus eggs reflect the metachronous cell-cycle state of the cytoplasm. Current Biology : Cb. 7: 451-4. PMID 9197242  1
1997 Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Development. 11: 1409-21. PMID 9192869  1
1997 Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW. Systematic identification of mitotic phosphoproteins. Current Biology : Cb. 7: 338-48. PMID 9115395  1
1996 Lustig KD, Kroll KL, Sun EE, Kirschner MW. Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development (Cambridge, England). 122: 4001-12. PMID 9012520  1
1996 Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes & Development. 10: 3081-93. PMID 8985178  1
1996 King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science (New York, N.Y.). 274: 1652-9. PMID 8939846 DOI: 10.1126/science.274.5293.1652  1
1996 Lustig KD, Kroll K, Sun E, Ramos R, Elmendorf H, Kirschner MW. Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation Development. 122: 3275-3282. PMID 8898239  1
1996 Peters JM, King RW, Höög C, Kirschner MW. Identification of BIME as a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 274: 1199-201. PMID 8895470 DOI: 10.1126/science.274.5290.1199  1
1996 King RW, Glotzer M, Kirschner MW. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Molecular Biology of the Cell. 7: 1343-57. PMID 8885231  1
1996 Yu H, King RW, Peters JM, Kirschner MW. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Current Biology : Cb. 6: 455-66. PMID 8723350  1
1996 Lee TH, Kirschner MW. An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts Proceedings of the National Academy of Sciences of the United States of America. 93: 352-356. PMID 8552637  1
1995 Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature. 374: 386-8. PMID 7885482 DOI: 10.1038/374386a0  1
1995 Tanaka E, Ho T, Kirschner MW. The role of microtubule dynamics in growth cone motility and axonal growth Journal of Cell Biology. 128: 139-155. PMID 7822411  1
1995 Tanaka E, Kirschner MW. The role of microtubules in growth cone turning at substrate boundaries Journal of Cell Biology. 128: 127-137. PMID 7822410  1
1995 King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81: 279-88. PMID 7736580 DOI: 10.1016/0092-8674(95)90338-0  1
1995 Brandli AW, Kirschner MW. Molecular cloning of tyrosine kinases in the early Xenopus embryo: Identification of Eck-related genes expressed in cranial neural crest cells of the second (hyoid) arch Developmental Dynamics. 203: 119-140. PMID 7655077  1
1995 Jackson PK, Chevalier S, Philippe M, Kirschner MW. Early events in DNA replication require cyclin E and are blocked by p21CIP1. The Journal of Cell Biology. 130: 755-69. PMID 7642695  1
1995 Kinoshita N, Minshull J, Kirschner MW. The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development Cell. 83: 621-630. PMID 7585965 DOI: 10.1016/0092-8674(95)90102-7  1
1995 Sabry J, O'Connor TP, Kirschner MW. Axonal transport of tubulin in tit pioneer neurons in situ Neuron. 14: 1247-1256. PMID 7541635 DOI: 10.1016/0896-6273(95)90271-6  1
1995 Lustig KD, Kirschner MW. Use of an oocyte expression assay to reconstitute inductive signaling Proceedings of the National Academy of Sciences of the United States of America. 92: 6234-6238. PMID 7541533 DOI: 10.1073/pnas.92.14.6234  1
1994 Lee TH, Turck C, Kirschner MW. Inhibition of cdc2 activation by INH/PP2A Molecular Biology of the Cell. 5: 323-338. PMID 8049524  1
1994 King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell. 79: 563-71. PMID 7954823 DOI: 10.1016/0092-8674(94)90542-8  1
1994 Kirschner MW, Marincola E, Teisberg EO. The role of biomedical research in health care reform Science. 266: 49-51. PMID 7939643  1
1994 Drechsel DN, Kirschner MW. The minimum GTP cap required to stabilize microtubules Current Biology. 4: 1053-1061. PMID 7704569 DOI: 10.1016/S0960-9822(00)00243-8  1
1993 Booher RN, Deshaies RJ, Kirschner MW. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. The Embo Journal. 12: 3417-26. PMID 8253069  1
1993 Amaya E, Stein PA, Musci TJ, Kirschner MW. FGF signalling in the early specification of mesoderm in Xenopus. Development (Cambridge, England). 118: 477-87. PMID 8223274  1
1992 Solomon MJ, Lee T, Kirschner MW. Role of phosphorylation in p34cdc2 activation: identification of an activating kinase. Molecular Biology of the Cell. 3: 13-27. PMID 1532335  1
1992 Drechsel DN, Hyman AA, Cobb MH, Kirschner MW. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau Molecular Biology of the Cell. 3: 1141-1154. PMID 1421571  1
1991 Butner KA, Kirschner MW. Tau protein binds to microtubules through a flexible array of distributed weak sites Journal of Cell Biology. 115: 717-730. PMID 1918161 DOI: 10.1083/jcb.115.3.717  1
1991 Tanaka EM, Kirschner MW. Microtubule behavior in the growth cones of living neurons during axon elongation Journal of Cell Biology. 115: 345-363. PMID 1918145 DOI: 10.1083/jcb.115.2.345  1
1991 Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 67: 197-211. PMID 1913817 DOI: 10.1016/0092-8674(91)90583-K  1
1991 Lee TH, Solomon MJ, Mumby MC, Kirschner MW. INH, a negative regulator of MPF, is a form of protein phosphatase 2A. Cell. 64: 415-23. PMID 1846321 DOI: 10.1016/0092-8674(91)90649-J  1
1991 Glotzer M, Murray AW, Kirschner MW. Cyclin is degraded by the ubiquitin pathway. Nature. 349: 132-8. PMID 1846030 DOI: 10.1038/349132a0  1
1991 Solomon MJ, Gautier J, Lee T, Kirschner MW. Control of p34cdc2 activation. Cold Spring Harbor Symposia On Quantitative Biology. 56: 427-35. PMID 1840256  1
1991 Murray AW, Kirschner MW. What controls the cell cycle? Scientific American. 264: 56-63. PMID 1828616  1
1991 Amaya E, Musci TJ, Kirschner MW. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos Cell. 66: 257-270. PMID 1649700  1
1990 Ward GE, Kirschner MW. Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C Cell. 61: 561-577. PMID 2188730 DOI: 10.1016/0092-8674(90)90469-U  1
1990 Musci TJ, Amaya E, Kirschner MW. Regulation of the fibroblast growth factor receptor in early Xenopus embryos Proceedings of the National Academy of Sciences of the United States of America. 87: 8365-8369. PMID 2172985  1
1990 Solomon MJ, Glotzer M, Lee TH, Philippe M, Kirschner MW. Cyclin activation of p34cdc2. Cell. 63: 1013-24. PMID 2147872 DOI: 10.1016/0092-8674(90)90504-8  1
1990 Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Söling HD, Drechsel D, Kirschner MW. Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. The Embo Journal. 9: 3539-44. PMID 2120043  1
1989 Murray AW, Kirschner MW. Dominoes and clocks: the union of two views of the cell cycle. Science (New York, N.Y.). 246: 614-21. PMID 2683077  1
1989 Murray AW, Solomon MJ, Kirschner MW. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature. 339: 280-6. PMID 2566918 DOI: 10.1038/339280a0  1
1989 Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature. 339: 275-80. PMID 2566917 DOI: 10.1038/339275a0  1
1988 Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 331: 499-504. PMID 3340202 DOI: 10.1038/331499a0  1
1987 Krohne G, Wolin SL, McKeon FD, Franke WW, Kirschner MW. Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily. The Embo Journal. 6: 3801-8. PMID 3428276  1
1987 Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophysics. 11: 35-55. PMID 2450668  1
1986 Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods in Enzymology. 134: 261-8. PMID 3821566  1
1986 McKeon FD, Kirschner MW, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 319: 463-8. PMID 3453101 DOI: 10.1038/319463a0  1
1986 Drubin DG, Kirschner MW. Tau protein function in living cells. The Journal of Cell Biology. 103: 2739-46. PMID 3098742  1
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. The Journal of Cell Biology. 101: 766-77. PMID 4030894  1
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. The Journal of Cell Biology. 101: 755-65. PMID 4030893  1
1985 Drubin DG, Feinstein SC, Shooter EM, Kirschner MW. Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. The Journal of Cell Biology. 101: 1799-807. PMID 2997236  1
1984 Drubin DG, Caput D, Kirschner MW. Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. The Journal of Cell Biology. 98: 1090-7. PMID 6421824  1
1984 McKeon FD, Tuffanelli DL, Kobayashi S, Kirschner MW. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation. Cell. 36: 83-92. PMID 6420073 DOI: 10.1016/0092-8674(84)90076-X  1
1984 Newport JW, Kirschner MW. Regulation of the cell cycle during early Xenopus development. Cell. 37: 731-42. PMID 6378387 DOI: 10.1016/0092-8674(84)90409-4  1
1984 Forbes DJ, Kirschner MW, Caput D, Dahlberg JE, Lund E. Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis. Cell. 38: 681-9. PMID 6207932 DOI: 10.1016/0092-8674(84)90263-0  1
1983 Forbes DJ, Kirschner MW, Newport JW. Spontaneous formation of nucleus-like structures around bacteriophage DNA microinjected into Xenopus eggs. Cell. 34: 13-23. PMID 6224569 DOI: 10.1016/0092-8674(83)90132-0  1
1983 McKeon FD, Tuffanelli DL, Fukuyama K, Kirschner MW. Autoimmune response directed against conserved determinants of nuclear envelope proteins in a patient with linear scleroderma. Proceedings of the National Academy of Sciences of the United States of America. 80: 4374-8. PMID 6192431  1
1983 Forbes DJ, Kornberg TB, Kirschner MW. Small nuclear RNA transcription and ribonucleoprotein assembly in early Xenopus development. The Journal of Cell Biology. 97: 62-72. PMID 6190822  1
1981 Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 289: 650-5. PMID 7464932 DOI: 10.1038/289650a0  1
1981 Cleveland DW, Hughes SH, Stubblefield E, Kirschner MW, Varmus HE. Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. The Journal of Biological Chemistry. 256: 3130-4. PMID 6259149  0.68
1981 Cleveland DW, Lopata MA, Sherline P, Kirschner MW. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 25: 537-46. PMID 6116546  0.92
1980 Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 20: 95-105. PMID 6893015 DOI: 10.1016/0092-8674(80)90238-X  1
1980 Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 22: 845-54. PMID 6780200 DOI: 10.1016/0092-8674(80)90561-9  1
1979 Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 16: 253-63. PMID 455435  0.92
1979 Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 16: 239-52. PMID 455434  0.92
1979 Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. The Journal of Biological Chemistry. 254: 12670-8. PMID 227904  0.92
1978 Cleveland DW, Kirschner MW, Cowan NJ. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 15: 1021-31. PMID 728983 DOI: 10.1016/0092-8674(78)90286-6  1
1978 Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. The Journal of Cell Biology. 76: 781-6. PMID 344329  0.68
1977 Cleveland DW, Hwo SY, Kirschner MW. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. Journal of Molecular Biology. 116: 207-25. PMID 599557  0.68
1977 Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 12: 587-600. PMID 562716 DOI: 10.1016/0092-8674(77)90259-8  1
1977 Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proceedings of the National Academy of Sciences of the United States of America. 74: 2437-40. PMID 329285  0.68
1977 Cleveland DW, Fischer SG, Kirschner MW, Laemmli UK. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. The Journal of Biological Chemistry. 252: 1102-6. PMID 320200  0.68
1977 Cleveland DW, Hwo SY, Kirschner MW. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. Journal of Molecular Biology. 116: 227-47. PMID 146092  0.68
1976 Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. Tubulin requires tau for growth onto microtubule initiating sites. Proceedings of the National Academy of Sciences of the United States of America. 73: 4070-4. PMID 1069293  0.68
1974 Springer MS, Kirschner MW, Schachman HK. A difference sedimentation equilibrium technique for measuring small changes in molecular weight. I. Theory and computer simulation. Biochemistry. 13: 3718-26. PMID 4850196  1
1974 Kirschner MW, Williams RC, Weingarten M, Gerhart JC. Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. Proceedings of the National Academy of Sciences of the United States of America. 71: 1159-63. PMID 4524627  1
Show low-probability matches.