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Emily H. Cheng - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology
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74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gitego N, Agianian B, Mak OW, Kumar Mv V, Cheng EH, Gavathiotis E. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nature Communications. 14: 8381. PMID 38104127 DOI: 10.1038/s41467-023-44084-3  0.475
2023 Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Cheng EH, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w  0.638
2020 Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, ... ... Cheng EH, et al. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. PMID 32359397 DOI: 10.1016/J.Ccell.2020.04.002  0.32
2019 Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra JG, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka ZP, Casuscelli J, ... ... Cheng EH, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 8. PMID 30924768 DOI: 10.7554/Elife.38986  0.356
2019 Xu J, Reznik E, Lee H, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, ... ... Cheng EH, et al. Author response: Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma Elife. DOI: 10.7554/Elife.38986.025  0.319
2019 Tanaka K, Han S, Ganesan YT, Hsieh JJ, Cheng EH. Abstract 698: Enhancing apoptosis to improve the therapy ofEGFR-mutant lung cancer Cancer Research. 79: 698-698. DOI: 10.1158/1538-7445.Am2019-698  0.353
2018 Dong Y, Eskandari R, Ray C, Granlund KL, Dos Santos-Cunha L, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. Hyperpolarized MRI visualizes Warburg effects and predicts treatment response to mTOR inhibitors in patient-derived ccRCC xenograft models. Cancer Research. PMID 30459151 DOI: 10.1158/0008-5472.Can-18-2231  0.328
2018 Hsieh JJ, Le VH, Oyama T, Ricketts CJ, Ho TH, Cheng EH. Chromosome 3p Loss-Orchestrated VHL, HIF, and Epigenetic Deregulation in Clear Cell Renal Cell Carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2018792549. PMID 30372397 DOI: 10.1200/Jco.2018.79.2549  0.4
2018 Jeng PS, Inoue-Yamauchi A, Hsieh JJ, Cheng EH. BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. Current Opinion in Physiology. 3: 71-81. PMID 30334018 DOI: 10.1016/J.Cophys.2018.03.005  0.535
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Cheng EH, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.72
2017 Hsieh JJ, Le V, Cao D, Cheng EH, Creighton CJ. Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision. The Journal of Pathology. PMID 29266437 DOI: 10.1002/Path.5022  0.315
2017 Wang GX, Tu HC, Dong Y, Skanderup AJ, Wang Y, Takeda S, Ganesan YT, Han S, Liu H, Hsieh JJ, Cheng EH. ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival. Cell Reports. 21: 2926-2939. PMID 29212036 DOI: 10.1016/J.Celrep.2017.11.030  0.644
2017 Becerra MF, Reznik E, Redzematovic A, Tennenbaum DM, Kashan M, Ghanaat M, Casuscelli J, Manley B, Jonsson P, DiNatale RG, Blum KA, Durack JC, Solomon SB, Arcila ME, Bourque C, ... ... Cheng EH, et al. Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma. European Urology Focus. PMID 29066084 DOI: 10.1016/J.Euf.2017.09.016  0.304
2017 Nargund AM, Osmanbeyoglu HU, Cheng EH, Hsieh JJ. SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer. Molecular & Cellular Oncology. 4: e1342747. PMID 28868352 DOI: 10.1080/23723556.2017.1342747  0.33
2017 Inoue-Yamauchi A, Jeng PS, Kim K, Chen HC, Han S, Ganesan YT, Ishizawa K, Jebiwott S, Dong Y, Pietanza MC, Hellmann MD, Kris MG, Hsieh JJ, Cheng EH. Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nature Communications. 8: 16078. PMID 28714472 DOI: 10.1038/Ncomms16078  0.542
2017 Fujiki Y, Miyata N, Mukai S, Okumoto K, Cheng EH. BAK regulates catalase release from peroxisomes. Molecular & Cellular Oncology. 4: e1306610. PMID 28616584 DOI: 10.1080/23723556.2017.1306610  0.409
2017 Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, ... ... Cheng EH, et al. The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Reports. 18: 2893-2906. PMID 28329682 DOI: 10.1016/J.Celrep.2017.02.074  0.361
2017 Şenbabaoğlu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, Weinhold N, Lee W, Manley BJ, Khalil DN, Kaffenberger SD, ... ... Cheng EH, et al. Erratum to: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Genome Biology. 18: 46. PMID 28249590 DOI: 10.1186/S13059-017-1180-8  0.313
2017 Hosoi KI, Miyata N, Mukai S, Furuki S, Okumoto K, Cheng EH, Fujiki Y. The VDAC2-BAK axis regulates peroxisomal membrane permeability. The Journal of Cell Biology. PMID 28174205 DOI: 10.1083/Jcb.201605002  0.419
2016 Dong Y, Manley BJ, Becerra MF, Redzematovic A, Casuscelli J, Tennenbaum DM, Reznik E, Han S, Benfante N, Chen YB, Arcila ME, Aras O, Voss MH, Feldman DR, Motzer RJ, ... ... Cheng EH, et al. Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples. European Urology Focus. PMID 28753786 DOI: 10.1016/J.Euf.2016.08.005  0.351
2016 Şenbabaoğlu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, Weinhold N, Lee W, Manley BJ, Khalil DN, Kaffenberger SD, ... ... Cheng EH, et al. Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Genome Biology. 17: 231. PMID 27855702 DOI: 10.1186/S13059-016-1092-Z  0.319
2016 Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Cheng EH, Gavathiotis E. An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Molecular Cell. 64: 431. PMID 27768876 DOI: 10.1016/J.Molcel.2016.10.005  0.393
2016 Hsieh JJ, Cheng EH. A braided cancer river connects tumor heterogeneity and precision medicine. Clinical and Translational Medicine. 5: 42. PMID 27766604 DOI: 10.1186/S40169-016-0123-4  0.31
2016 Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, ... ... Cheng EH, et al. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nature Communications. 7: 13131. PMID 27713405 DOI: 10.1038/Ncomms13131  0.373
2016 Hsieh JJ, Manley B, Khan N, Gao J, Carlo MI, Cheng EH. Overcome Tumor Heterogeneity-Imposed Therapeutic Barriers through Convergent Genomic Biomarker Discovery: A Braided Cancer River Model of Kidney Cancer. Seminars in Cell & Developmental Biology. PMID 27615548 DOI: 10.1016/J.Semcdb.2016.09.002  0.333
2016 Mandal T, Shin S, Aluvila S, Chen HC, Grieve C, Choe JY, Cheng EH, Hustedt EJ, Oh KJ. Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore. Scientific Reports. 6: 30763. PMID 27488021 DOI: 10.1038/Srep30763  0.348
2016 Xu J, Pham CG, Albanese SK, Dong Y, Oyama T, Lee CH, Rodrik-Outmezguine V, Yao Z, Han S, Chen D, Parton DL, Chodera JD, Rosen N, Cheng EH, Hsieh JJ. Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin. The Journal of Clinical Investigation. PMID 27482884 DOI: 10.1172/Jci86120  0.398
2016 Garner TP, Reyna DE, Priyadarshi A, Chen HC, Li S, Wu Y, Ganesan YT, Malashkevich VN, Almo SS, Cheng EH, Gavathiotis E. An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway. Molecular Cell. PMID 27425408 DOI: 10.1016/J.Molcel.2016.06.010  0.509
2016 Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, ... ... Cheng EH, et al. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. 29: 104-116. PMID 26766592 DOI: 10.1016/J.Ccell.2015.12.004  0.308
2016 Lee C, Wei E, Lee W, Chen Y, Mano R, Hakimi AA, Dong Y, Redzematovic A, Cross JR, Tickoo S, Srinivasan R, Oschwald D, Reuter VE, Dunphy M, Cheng E, et al. Genomic and metabolic characterization of succinate dehydrogenase B deficient renal cell carcinoma. Journal of Clinical Oncology. 34. DOI: 10.1200/Jco.2016.34.15_Suppl.E16102  0.304
2016 Inoue-Yamauchi A, Jeng P, Kim K, Chen H, Han S, Ganesan YT, Dong Y, Jebiwott S, Hsieh JJ, Cheng EH. Abstract 3555: Targeting the BCL-2 family in small cell lung caner Cancer Research. 76: 3555-3555. DOI: 10.1158/1538-7445.Am2016-3555  0.482
2015 Niizuma H, Cheng EH, Hsieh JJ. Taspase 1: A protease with many biological surprises. Molecular & Cellular Oncology. 2: e999513. PMID 27308523 DOI: 10.1080/23723556.2014.999513  0.37
2015 Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature Cell Biology. PMID 26344567 DOI: 10.1038/Ncb3236  0.735
2015 Takeda S, Sasagawa S, Oyama T, Searleman AC, Westergard TD, Cheng EH, Hsieh JJ. Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. The Journal of Clinical Investigation. 125: 1203-14. PMID 25664857 DOI: 10.1172/Jci77075  0.335
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Cheng EH, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.726
2015 Hsieh J, Chen D, Wang P, Chen Y, Redzematovic A, Marker M, Patel P, Chevinsky M, Bhanot U, Pinciroli P, Bouvier N, Huberman KH, Berger MF, Socci ND, Cheng E, et al. Identification of efficacy biomarkers in a large metastatic renal cell carcinoma (mRCC) cohort through next generation sequencing (NGS): Results from RECORD-3. Journal of Clinical Oncology. 33: 4509-4509. DOI: 10.1200/Jco.2015.33.15_Suppl.4509  0.308
2015 Mano R, Lee W, Sankin A, Chevinsky M, Wang P, Djesevic A, Motzer R, Cheng E, Russo P, Oschwald D, Bhanot U, Tickoo S, Hakimi AA, Hsieh J. MP47-09 MOLECULAR CHARACTERIZATION OF SARCOMATOID CLEAR CELL RENAL CELL CARCINOMA Journal of Urology. 193. DOI: 10.1016/J.Juro.2015.02.1529  0.363
2014 Dong Y, Van Tine BA, Oyama T, Wang PI, Cheng EH, Hsieh JJ. Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. Cell Research. 24: 1354-66. PMID 25267403 DOI: 10.1038/Cr.2014.129  0.323
2014 Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Molecular Cell. 56: 205-18. PMID 25242145 DOI: 10.1016/J.Molcel.2014.08.018  0.454
2014 Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R, Pham CG, DiPersio J, Cheng EH, Hsieh JJ. Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4. Cancer Cell. 25: 530-42. PMID 24735925 DOI: 10.1016/J.Ccr.2014.03.008  0.433
2014 Ren D, Sun J, Wang C, Ye H, Mao L, Cheng EH, Bell GI, Polonsky KS. Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency. Diabetes. 63: 2744-50. PMID 24658302 DOI: 10.2337/Db13-1513  0.443
2013 Oyama T, Sasagawa S, Takeda S, Hess RA, Lieberman PM, Cheng EH, Hsieh JJ. Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Developmental Cell. 27: 188-200. PMID 24176642 DOI: 10.1016/J.Devcel.2013.09.025  0.337
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife. 2: e00772. PMID 23991283 DOI: 10.7554/Elife.00772  0.345
2013 Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ. HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. The Journal of Clinical Investigation. 123: 3154-65. PMID 23934123 DOI: 10.1172/Jci65566  0.349
2013 Jeng PS, Cheng EH. Cancer therapeutics: Pulling the plug on BCL-X(L). Nature Chemical Biology. 9: 351-2. PMID 23689630 DOI: 10.1038/Nchembio.1256  0.467
2013 Hakimi AA, Ostrovnaya I, Reva B, Schultz N, Chen YB, Gonen M, Liu H, Takeda S, Voss MH, Tickoo SK, Reuter VE, Russo P, Cheng EH, Sander C, Motzer RJ, et al. Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3259-67. PMID 23620406 DOI: 10.1158/1078-0432.Ccr-12-3886  0.32
2013 Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJ, Cheng EH. PUMA and BIM are required for oncogene inactivation-induced apoptosis. Science Signaling. 6: ra20. PMID 23532334 DOI: 10.1126/Scisignal.2003483  0.303
2013 Hakimi AA, Chen YB, Wren J, Gonen M, Abdel-Wahab O, Heguy A, Liu H, Takeda S, Tickoo SK, Reuter VE, Voss MH, Motzer RJ, Coleman JA, Cheng EH, Russo P, et al. Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma. European Urology. 63: 848-54. PMID 23036577 DOI: 10.1016/J.Eururo.2012.09.005  0.309
2013 Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD. Author response: Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice Elife. DOI: 10.7554/Elife.00772.020  0.402
2013 Voss MH, Hakimi AA, Pham CG, Brannon AR, Chen Y, Cunha LF, Akin O, Liu H, Takeda S, Scott SN, Socci ND, Viale A, Schultz N, Sander C, Reuter VE, ... ... Cheng EH, et al. Abstract 3515: Pathway convergent evolution underscores treatment response to MTOR inhibitors in kidney cancers. Cancer Research. 73: 3515-3515. DOI: 10.1158/1538-7445.Am2013-3515  0.345
2013 Hakimi AA, Ostrovnaya I, Reva B, Schultz N, Chen Y, Gonen M, Liu H, Takeda S, Tickoo SK, Voss MH, Cheng EH, Reuter VE, Motzer RJ, Russo P, Hsieh JJ. 1068 ADVERSE OUTCOMES IN CLEAR CELL RENAL CELL CARCINOMA WITH MUTATIONS OF EPIGENETIC REGULATORS BAP1 AND SETD2 Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.657  0.327
2012 Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C. A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. Plos One. 7: e37782. PMID 22719850 DOI: 10.1371/Journal.Pone.0037782  0.535
2012 Rodriguez DA, Zamorano S, Lisbona F, Rojas-Rivera D, Urra H, Cubillos-Ruiz JR, Armisen R, Henriquez DR, Cheng EH, Letek M, Vaisar T, Irrazabal T, Gonzalez-Billault C, Letai A, Pimentel-Muiños FX, et al. BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α. The Embo Journal. 31: 2322-35. PMID 22510886 DOI: 10.1038/Emboj.2012.84  0.377
2012 Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, ... Cheng EH, et al. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Research. 72: 736-46. PMID 22166309 DOI: 10.1158/0008-5472.Can-11-2584  0.566
2010 Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science (New York, N.Y.). 330: 1390-3. PMID 21127253 DOI: 10.1126/Science.1190217  0.715
2010 Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ. Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis. Cancer Research. 70: 5358-67. PMID 20516119 DOI: 10.1158/0008-5472.Can-10-0027  0.595
2010 Chen Y, Lewis W, Diwan A, Cheng EH, Matkovich SJ, Dorn GW. Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 107: 9035-42. PMID 20418503 DOI: 10.1073/pnas.0914013107  0.457
2009 Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Molecular Cell. 36: 487-99. PMID 19917256 DOI: 10.1016/J.Molcel.2009.09.030  0.687
2009 Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH. The VDAC2-BAK rheostat controls thymocyte survival. Science Signaling. 2: ra48. PMID 19706873 DOI: 10.1126/Scisignal.2000274  0.687
2009 Kim H, Hsieh JJ, Cheng EH. Deadly splicing: Bax becomes Almighty. Molecular Cell. 33: 145-6. PMID 19187757 DOI: 10.1016/J.Molcel.2009.01.004  0.507
2009 Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ, Cheng EH. The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 106: 1093-8. PMID 19144918 DOI: 10.1073/Pnas.0808173106  0.699
2009 Cheng E. Molecular Control of Mitochondrial Apoptosis by the BCL-2 Family. Blood. 114: SCI-13-SCI-13. DOI: 10.1182/Blood.V114.22.Sci-13.Sci-13  0.578
2009 Liu H, Takeda S, Kumar R, Westergard T, Pandita T, Cheng E, Hsieh JJ. A Novel Function of MLL in the S Phase Checkpoint: MLL Is Phosphorylated by ATR Upon DNA Damage, Which Blocks Its Degradation by the SCFskp2 Proteasome, Leading to Its Accumulation That Directly Inhibits DNA Replication. Blood. 114: 450-450. DOI: 10.1182/Blood.V114.22.450.450  0.301
2008 Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature. 455: 1076-81. PMID 18948948 DOI: 10.1038/Nature07396  0.702
2008 Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z. Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa. International Journal of Radiation Oncology, Biology, Physics. 70: 804-15. PMID 18191336 DOI: 10.1016/J.Ijrobp.2007.11.043  0.303
2008 Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu H, Kim H, Cheng E, Tjandra N, Walensky LD. Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis Blood. 112: 300-300. DOI: 10.1182/Blood.V112.11.300.300  0.738
2006 Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nature Cell Biology. 8: 1348-58. PMID 17115033 DOI: 10.1038/Ncb1499  0.697
2006 Hsieh JJ, Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, Kan JT, Korsmeyer SJ, Cheng EH. Proteolysis of MLL Family Proteins Is Essential for Taspase1−Orchestrated Cell Cycle Progression. Blood. 108: 769-769. DOI: 10.1182/Blood.V108.11.769.769  0.363
2005 Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ. Proapoptotic BAX and BAK control multiple initiator caspases. Embo Reports. 6: 379-85. PMID 15776018 DOI: 10.1038/Sj.Embor.7400375  0.421
2003 Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ. VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (New York, N.Y.). 301: 513-7. PMID 12881569 DOI: 10.1126/Science.1083995  0.449
2003 Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (New York, N.Y.). 300: 135-9. PMID 12624178 DOI: 10.1126/Science.1081208  0.346
2001 Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular Cell. 8: 705-11. PMID 11583631 DOI: 10.1016/S1097-2765(01)00320-3  0.408
2001 Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (New York, N.Y.). 292: 727-30. PMID 11326099 DOI: 10.1126/Science.1059108  0.427
1996 Cheng EH, Levine B, Boise LH, Thompson CB, Hardwick JM. Bax-independent inhibition of apoptosis by Bcl-XL. Nature. 379: 554-6. PMID 8596636 DOI: 10.1038/379554A0  0.715
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