| Year |
Citation |
Score |
| 2024 |
Woolley PR, Wen X, Conway OM, Ender NA, Lee JH, Paull TT. Regulation of transcription patterns, poly(ADP-ribose), and RNA-DNA hybrids by the ATM protein kinase. Cell Reports. 43: 113896. PMID 38442018 DOI: 10.1016/j.celrep.2024.113896 |
0.387 |
|
| 2023 |
Woolley PR, Wen X, Conway OM, Ender NA, Lee JH, Paull TT. Regulation of transcription patterns, poly-ADP-ribose, and RNA-DNA hybrids by the ATM protein kinase. Biorxiv : the Preprint Server For Biology. PMID 38106035 DOI: 10.1101/2023.12.06.570417 |
0.384 |
|
| 2023 |
Deshpande RA, Marin-Gonzalez A, Barnes HK, Woolley PR, Ha T, Paull TT. Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice. Nature Communications. 14: 5759. PMID 37717054 DOI: 10.1038/s41467-023-41544-8 |
0.629 |
|
| 2023 |
Myler LR, Toia B, Vaughan CK, Takai K, Matei AM, Wu P, Paull TT, de Lange T, Lottersberger F. DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres. Nature Structural & Molecular Biology. PMID 37653239 DOI: 10.1038/s41594-023-01072-x |
0.61 |
|
| 2022 |
Jeong H, Wie M, Baek IJ, Sohn G, Um SH, Lee SG, Seo Y, Ra J, Lee EA, Kim S, Kim BG, Deshpande RA, Paull TT, Han JS, Kwon T, et al. TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11. Cells. 11. PMID 36552858 DOI: 10.3390/cells11244095 |
0.599 |
|
| 2022 |
Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, ... ... Paull TT, et al. METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Nature Cancer. 3: 1088-1104. PMID 36138131 DOI: 10.1038/s43018-022-00429-3 |
0.413 |
|
| 2022 |
Lin WL, Chen JK, Wen X, He W, Zarceno GA, Chen Y, Chen S, Paull TT, Liu HW. DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1. Cell Reports. 40: 111089. PMID 35858569 DOI: 10.1016/j.celrep.2022.111089 |
0.394 |
|
| 2022 |
Deshpande RA, Paull TT. Characterization of DNA-PK-Bound End Fragments Using GLASS-ChIP. Methods in Molecular Biology (Clifton, N.J.). 2444: 171-182. PMID 35290638 DOI: 10.1007/978-1-0716-2063-2_11 |
0.558 |
|
| 2021 |
Deshpande RA, Paull TT. Characterization of DNA-PK-bound end fragments using GLASS-ChIP. Methods in Enzymology. 661: 205-217. PMID 34776213 DOI: 10.1016/bs.mie.2021.08.014 |
0.558 |
|
| 2021 |
Lee JH, Paull TT. Cellular functions of the protein kinase ATM and their relevance to human disease. Nature Reviews. Molecular Cell Biology. PMID 34429537 DOI: 10.1038/s41580-021-00394-2 |
0.408 |
|
| 2021 |
Paull TT. Reconsidering pathway choice: a sequential model of mammalian DNA double-strand break pathway decisions. Current Opinion in Genetics & Development. 71: 55-62. PMID 34293662 DOI: 10.1016/j.gde.2021.06.011 |
0.475 |
|
| 2021 |
Paull TT. DNA damage and regulation of protein homeostasis. Dna Repair. 105: 103155. PMID 34116476 DOI: 10.1016/j.dnarep.2021.103155 |
0.553 |
|
| 2021 |
Somyajit K, Spies J, Coscia F, Kirik U, Rask MB, Lee JH, Neelsen KJ, Mund A, Jensen LJ, Paull TT, Mann M, Lukas J. Homology-directed repair protects the replicating genome from metabolic assaults. Developmental Cell. 56: 461-477.e7. PMID 33621493 DOI: 10.1016/j.devcel.2021.01.011 |
0.546 |
|
| 2021 |
Zhou Y, Paull TT. Quantifying DNA End Resection in Human Cells. Methods in Molecular Biology (Clifton, N.J.). 2153: 59-69. PMID 32840772 DOI: 10.1007/978-1-0716-0644-5_5 |
0.56 |
|
| 2020 |
Milanovic M, Houghton LM, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, McKinnon PJ, Paull TT, Zha S. The cancer-associated ATM R3008H mutation reveals the link between ATM activation and its exchange. Cancer Research. PMID 33239428 DOI: 10.1158/0008-5472.CAN-20-2447 |
0.469 |
|
| 2020 |
Ryu SW, Stewart R, Pectol DC, Ender NA, Wimalarathne O, Lee JH, Zanini CP, Harvey A, Huibregtse JM, Mueller P, Paull TT. Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells. Plos Biology. 18: e3000606. PMID 32687490 DOI: 10.1371/Journal.Pbio.3000606 |
0.31 |
|
| 2020 |
Lee JH, Paull TT. Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species. Redox Biology. 32: 101511. PMID 32244177 DOI: 10.1016/J.Redox.2020.101511 |
0.397 |
|
| 2020 |
Kao CH, Ryu S, Kim MJ, Wen X, Wimalarathne O, Paull TT. Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenance. Molecular and Cellular Biology. PMID 32205407 DOI: 10.1128/Mcb.00628-19 |
0.342 |
|
| 2020 |
Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nature Communications. 11: 857. PMID 32051414 DOI: 10.1038/S41467-020-14654-W |
0.473 |
|
| 2020 |
Hu Q, Klages-Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, Srivastava M, Shen X, Tian Y, Kim H, Ye Y, Paull T, Takeda S, Chen J, Li L. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Reports. 30: 1235-1245.e4. PMID 31995761 DOI: 10.1016/J.Celrep.2019.12.067 |
0.608 |
|
| 2020 |
Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT. DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. Science Advances. 6: eaay0922. PMID 31934630 DOI: 10.1126/Sciadv.Aay0922 |
0.7 |
|
| 2019 |
Kim JJ, Lee SY, Gong F, Battenhouse AM, Boutz DR, Bashyal A, Refvik ST, Chiang CM, Xhemalce B, Paull TT, Brodbelt JS, Marcotte EM, Miller KM. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Genes & Development. PMID 31753913 DOI: 10.1101/Gad.331231.119 |
0.51 |
|
| 2019 |
Paull TT. RNA-DNA hybrids and the convergence with DNA repair. Critical Reviews in Biochemistry and Molecular Biology. 1-14. PMID 31577154 DOI: 10.1080/10409238.2019.1670131 |
0.617 |
|
| 2019 |
Soniat MM, Myler LR, Kuo HC, Paull TT, Finkelstein IJ. RPA Phosphorylation Inhibits DNA Resection. Molecular Cell. PMID 31153714 DOI: 10.1016/J.Molcel.2019.05.005 |
0.671 |
|
| 2019 |
Myler LR, Soniat MM, Zhang X, Deshpande RA, Paull TT, Finkelstein IJ. Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex. Methods in Molecular Biology (Clifton, N.J.). 2004: 269-287. PMID 31147924 DOI: 10.1007/978-1-4939-9520-2_20 |
0.649 |
|
| 2018 |
Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Sae2/CtIP prevents R-loop accumulation in eukaryotic cells. Elife. 7. PMID 30523780 DOI: 10.7554/Elife.42733 |
0.57 |
|
| 2018 |
Johnson TE, Lee JH, Myler LR, Zhou Y, Mosley TJ, Yang SH, Uprety N, Kim J, Paull TT. Homeodomain Proteins Directly Regulate ATM Kinase Activity. Cell Reports. 24: 1471-1483. PMID 30089259 DOI: 10.1016/J.Celrep.2018.06.089 |
0.625 |
|
| 2018 |
Paull TT. 20 Years of Mre11 Biology: No End in Sight. Molecular Cell. 71: 419-427. PMID 30057197 DOI: 10.1016/J.Molcel.2018.06.033 |
0.35 |
|
| 2018 |
Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Molecular Cell. PMID 30017584 DOI: 10.1016/J.Molcel.2018.06.018 |
0.611 |
|
| 2018 |
Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity. Science Signaling. 11. PMID 29991649 DOI: 10.1126/Scisignal.Aaq0702 |
0.499 |
|
| 2018 |
Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR. Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells. Cancer Cell. PMID 29805078 DOI: 10.1016/J.Ccell.2018.04.010 |
0.489 |
|
| 2018 |
Lee JH, Mand MR, Kao CH, Zhou Y, Ryu SW, Richards AL, Coon JJ, Paull TT. ATM directs DNA damage responses and proteostasis via genetically separable pathways. Science Signaling. 11. PMID 29317520 DOI: 10.1126/Scisignal.Aan5598 |
0.625 |
|
| 2017 |
Hewitt SL, Wong JB, Lee JH, Nishana M, Chen H, Coussens M, Arnal SM, Blumenberg LM, Roth DB, Paull TT, Skok JA. The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect. Cell Reports. 21: 979-993. PMID 29069605 DOI: 10.1016/J.Celrep.2017.09.084 |
0.539 |
|
| 2017 |
Arora S, Deshpande RA, Budd M, Campbell J, Revere A, Zhang X, Schmidt KH, Paull TT. Genetic separation of Sae2 nuclease activity from Mre11 nuclease functions in budding yeast. Molecular and Cellular Biology. PMID 28970327 DOI: 10.1128/Mcb.00156-17 |
0.666 |
|
| 2017 |
Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ. Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair. Molecular Cell. PMID 28867292 DOI: 10.1016/J.Molcel.2017.08.002 |
0.68 |
|
| 2017 |
Deshpande RA, Lee JH, Paull TT. Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites. Nucleic Acids Research. PMID 28369545 DOI: 10.1093/Nar/Gkx173 |
0.642 |
|
| 2017 |
Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes & Development. PMID 28242625 DOI: 10.1101/Gad.292516.116 |
0.634 |
|
| 2016 |
Zhou Y, Lee JH, Jiang W, Crowe JL, Zha S, Paull TT. Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM. Molecular Cell. PMID 27939942 DOI: 10.1016/J.Molcel.2016.11.004 |
0.707 |
|
| 2016 |
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Molecular Cell. 64: 1010. PMID 27912094 DOI: 10.1016/J.Molcel.2016.11.028 |
0.371 |
|
| 2016 |
Deshpande RA, Lee JH, Arora S, Paull TT. Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts. Molecular Cell. 64: 593-606. PMID 27814491 DOI: 10.1016/J.Molcel.2016.10.010 |
0.695 |
|
| 2016 |
Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsusui K, Takeda S, Sasanuma H. Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes. Molecular Cell. 64: 580-592. PMID 27814490 DOI: 10.1016/J.Molcel.2016.10.011 |
0.535 |
|
| 2016 |
Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. The Embo Journal. 35: 791. PMID 27037288 DOI: 10.15252/Embj.201694047 |
0.582 |
|
| 2016 |
Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ. Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884156 DOI: 10.1073/Pnas.1516674113 |
0.693 |
|
| 2016 |
Broderick R, Nieminuszczy J, Baddock HT, Deshpande RA, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W. EXD2 promotes homologous recombination by facilitating DNA end resection. Nature Cell Biology. PMID 26807646 DOI: 10.1038/Ncb3303 |
0.656 |
|
| 2016 |
Myler L, Gallardo I, Kim Y, Paull TT, Finkelstein IJ. Visualizing the First Steps of Human Double-Strand Break Repair on a Crowded DNA Track Biophysical Journal. 110: 65a. DOI: 10.1016/J.Bpj.2015.11.416 |
0.688 |
|
| 2015 |
Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nature Cell Biology. PMID 26344566 DOI: 10.1038/Ncb3230 |
0.347 |
|
| 2015 |
Makharashvili N, Paull TT. CtIP: A DNA damage response protein at the intersection of DNA metabolism. Dna Repair. 32: 75-81. PMID 25957490 DOI: 10.1016/J.Dnarep.2015.04.016 |
0.678 |
|
| 2015 |
Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. Plos One. 10: e0124495. PMID 25909997 DOI: 10.1371/Journal.Pone.0124495 |
0.664 |
|
| 2015 |
Zhou Y, Paull TT. Direct measurement of single-stranded DNA intermediates in mammalian cells by quantitative polymerase chain reaction. Analytical Biochemistry. 479: 48-50. PMID 25841672 DOI: 10.1016/J.Ab.2015.03.025 |
0.611 |
|
| 2015 |
Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle (Georgetown, Tex.). 14: 437-48. PMID 25659039 DOI: 10.4161/15384101.2014.972901 |
0.559 |
|
| 2015 |
Paull TT. Mechanisms of ATM Activation. Annual Review of Biochemistry. 84: 711-38. PMID 25580527 DOI: 10.1146/Annurev-Biochem-060614-034335 |
0.638 |
|
| 2015 |
Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull TT, Krejci L, Whitby MC, Zhao X. Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. Plos Genetics. 11: e1004899. PMID 25569253 DOI: 10.1371/Journal.Pgen.1004899 |
0.689 |
|
| 2014 |
Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. The Journal of Cell Biology. 206: 877-94. PMID 25267294 DOI: 10.1083/Jcb.201401146 |
0.569 |
|
| 2014 |
Paull TT, Deshpande RA. The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. Experimental Cell Research. 329: 139-47. PMID 25016281 DOI: 10.1016/J.Yexcr.2014.07.007 |
0.515 |
|
| 2014 |
Lee JH, Guo Z, Myler LR, Zheng S, Paull TT. Direct activation of ATM by resveratrol under oxidizing conditions. Plos One. 9: e97969. PMID 24933654 DOI: 10.1371/Journal.Pone.0097969 |
0.429 |
|
| 2014 |
Makharashvili N, Tubbs AT, Yang SH, Wang H, Barton O, Zhou Y, Deshpande RA, Lee JH, Lobrich M, Sleckman BP, Wu X, Paull TT. Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection. Molecular Cell. 54: 1022-33. PMID 24837676 DOI: 10.1016/J.Molcel.2014.04.011 |
0.642 |
|
| 2014 |
Paull TT, Lee JH. Rad17, the clamp loader that loads more than clamps. The Embo Journal. 33: 783-5. PMID 24619000 DOI: 10.1002/Embj.201488223 |
0.615 |
|
| 2014 |
Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, Lee JH, Classen S, Guenther G, Russell P, Tainer JA, Paull TT. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. The Embo Journal. 33: 482-500. PMID 24493214 DOI: 10.1002/Embj.201386100 |
0.687 |
|
| 2014 |
Zhou Y, Caron P, Legube G, Paull TT. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Research. 42: e19. PMID 24362840 DOI: 10.1093/Nar/Gkt1309 |
0.664 |
|
| 2014 |
Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT. Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme. Molecular and Cellular Biology. 34: 778-93. PMID 24344201 DOI: 10.1128/Mcb.00963-13 |
0.687 |
|
| 2014 |
Fu Q, Chow J, Bernstein KA, Makharashvili N, Arora S, Lee CF, Person MD, Rothstein R, Paull TT. Correction to Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme [Molecular and Cellular Biology, 34, 5, (2014), 778-793] Molecular and Cellular Biology. 34: 4213-4213. DOI: 10.1128/Mcb.01175-14 |
0.541 |
|
| 2013 |
Zhou Y, Paull TT. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). The Journal of Biological Chemistry. 288: 37112-25. PMID 24220101 DOI: 10.1074/Jbc.M113.514398 |
0.712 |
|
| 2013 |
Cannon B, Kuhnlein J, Yang SH, Cheng A, Schindler D, Stark JM, Russell R, Paull TT. Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET. Proceedings of the National Academy of Sciences of the United States of America. 110: 18868-73. PMID 24191051 DOI: 10.1073/Pnas.1309816110 |
0.703 |
|
| 2013 |
Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Reports. 4: 516-29. PMID 23890999 DOI: 10.1016/J.Celrep.2013.06.039 |
0.635 |
|
| 2013 |
Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. The Journal of Biological Chemistry. 288: 12840-51. PMID 23525106 DOI: 10.1074/Jbc.M113.460378 |
0.553 |
|
| 2013 |
Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. The Embo Journal. 32: 126-39. PMID 23178594 DOI: 10.1038/Emboj.2012.314 |
0.664 |
|
| 2012 |
Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A. Loss of ATM kinase activity leads to embryonic lethality in mice Journal of Cell Biology. 198: 295-304. PMID 22869595 DOI: 10.1083/Jcb.201204035 |
0.461 |
|
| 2012 |
Ditch S, Paull TT. The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. Trends in Biochemical Sciences. 37: 15-22. PMID 22079189 DOI: 10.1016/J.Tibs.2011.10.002 |
0.509 |
|
| 2012 |
Paull TT, Lee J, Ditch S, Guo Z. Abstract SY11-03: Mechanisms of ATM activation Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy11-03 |
0.479 |
|
| 2012 |
Ditch S, Paull TT. Abstract 2063: Oxidized ATM functions in intracellular redox regulation Cancer Research. 72: 2063-2063. DOI: 10.1158/1538-7445.Am2012-2063 |
0.501 |
|
| 2011 |
Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. The Journal of Biological Chemistry. 286: 33845-53. PMID 21816818 DOI: 10.1074/Jbc.M111.274159 |
0.667 |
|
| 2011 |
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. The Journal of Biological Chemistry. 286: 31542-56. PMID 21757780 DOI: 10.1074/Jbc.M111.258152 |
0.659 |
|
| 2010 |
Guo Z, Deshpande R, Paull TT. ATM activation in the presence of oxidative stress. Cell Cycle (Georgetown, Tex.). 9: 4805-11. PMID 21150274 DOI: 10.4161/Cc.9.24.14323 |
0.475 |
|
| 2010 |
Nicolette ML, Lee K, Guo Z, Rani M, Chow JM, Lee SE, Paull TT. Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks. Nature Structural & Molecular Biology. 17: 1478-85. PMID 21102445 DOI: 10.1038/Nsmb.1957 |
0.849 |
|
| 2010 |
Paull TT. Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection. Dna Repair. 9: 1283-91. PMID 21050828 DOI: 10.1016/J.Dnarep.2010.09.015 |
0.669 |
|
| 2010 |
Demogines A, East AM, Lee JH, Grossman SR, Sabeti PC, Paull TT, Sawyer SL. Ancient and recent adaptive evolution of primate non-homologous end joining genes. Plos Genetics. 6: e1001169. PMID 20975951 DOI: 10.1371/Journal.Pgen.1001169 |
0.423 |
|
| 2010 |
Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT. ATM activation by oxidative stress. Science (New York, N.Y.). 330: 517-21. PMID 20966255 DOI: 10.1126/Science.1192912 |
0.567 |
|
| 2010 |
Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE. Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. The Embo Journal. 29: 3370-80. PMID 20834227 DOI: 10.1038/Emboj.2010.219 |
0.845 |
|
| 2010 |
Lee JH, Goodarzi AA, Jeggo PA, Paull TT. 53BP1 promotes ATM activity through direct interactions with the MRN complex. The Embo Journal. 29: 574-85. PMID 20010693 DOI: 10.1038/Emboj.2009.372 |
0.583 |
|
| 2009 |
Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex (Nature Chemical Biology (2008) 4, (119-125)) Nature Chemical Biology. 5: 191. DOI: 10.1038/Nchembio0309-191A |
0.73 |
|
| 2008 |
Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Journal of Cell Biology. 183: 777-783. PMID 19047460 DOI: 10.1083/Jcb.200805154 |
0.638 |
|
| 2008 |
Hopkins BB, Paull TT. The P. furiosus mre11/rad50 complex promotes 5' strand resection at a DNA double-strand break. Cell. 135: 250-60. PMID 18957200 DOI: 10.1016/J.Cell.2008.09.054 |
0.684 |
|
| 2008 |
Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, et al. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature. 453: 677-81. PMID 18449195 DOI: 10.1038/Nature06883 |
0.853 |
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| 2008 |
Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nature Chemical Biology. 4: 119-25. PMID 18176557 DOI: 10.1038/Nchembio.63 |
0.838 |
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| 2007 |
Lee JH, Paull TT. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks Oncogene. 26: 7741-7748. PMID 18066086 DOI: 10.1038/Sj.Onc.1210872 |
0.609 |
|
| 2007 |
Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT. Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Molecular Cell. 28: 638-51. PMID 18042458 DOI: 10.1016/J.Molcel.2007.11.001 |
0.81 |
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| 2007 |
Takeda S, Nakamura K, Taniguchi Y, Paull TT. Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Molecular Cell. 28: 351-2. PMID 17996697 DOI: 10.1016/J.Molcel.2007.10.016 |
0.326 |
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| 2007 |
Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Research. 67: 3010-7. PMID 17409407 DOI: 10.1158/0008-5472.Can-06-4328 |
0.51 |
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| 2007 |
Bhaskara V, Dupré A, Lengsfeld B, Hopkins BB, Chan A, Lee JH, Zhang X, Gautier J, Zakian V, Paull TT. Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes. Molecular Cell. 25: 647-61. PMID 17349953 DOI: 10.1016/J.Molcel.2007.01.028 |
0.792 |
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| 2006 |
Lee JH, Paull TT. Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1. Methods in Enzymology. 408: 529-39. PMID 16793391 DOI: 10.1016/S0076-6879(06)08033-5 |
0.588 |
|
| 2006 |
Cheng WH, Kusumoto R, Opresko PL, Sui X, Huang S, Nicolette ML, Paull TT, Campisi J, Seidman M, Bohr VA. Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Research. 34: 2751-60. PMID 16714450 DOI: 10.1093/Nar/Gkl362 |
0.846 |
|
| 2006 |
Nussenzweig A, Paull T. DNA repair: tails of histones lost. Nature. 439: 406-7. PMID 16437102 DOI: 10.1038/439406A |
0.651 |
|
| 2006 |
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/J.Molcel.2005.11.025 |
0.645 |
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| 2005 |
Paull TT. Saving the ends for last: the role of pol mu in DNA end joining. Molecular Cell. 19: 294-6. PMID 16061176 DOI: 10.1016/J.Molcel.2005.07.008 |
0.554 |
|
| 2005 |
Zhang X, Paull TT. The Mre11/Rad50/Xrs2 complex and non-homologous end-joining of incompatible ends in S. cerevisiae. Dna Repair. 4: 1281-94. PMID 16043424 DOI: 10.1016/J.Dnarep.2005.06.011 |
0.641 |
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| 2005 |
Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, Paull TT, Lucchesi JC, Khanna KK, Ludwig T, Pandita TK. Involvement of human MOF in ATM function. Molecular and Cellular Biology. 25: 5292-305. PMID 15923642 DOI: 10.1128/Mcb.25.12.5292-5305.2005 |
0.573 |
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| 2005 |
Paull TT, Lee JH. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle (Georgetown, Tex.). 4: 737-40. PMID 15908798 DOI: 10.4161/Cc.4.6.1715 |
0.717 |
|
| 2005 |
Lee JH, Paull TT. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (New York, N.Y.). 308: 551-4. PMID 15790808 DOI: 10.1126/Science.1108297 |
0.719 |
|
| 2004 |
Costanzo V, Paull T, Gottesman M, Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. Plos Biology. 2: E110. PMID 15138496 DOI: 10.1371/Journal.Pbio.0020110 |
0.69 |
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| 2004 |
Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (New York, N.Y.). 304: 93-6. PMID 15064416 DOI: 10.1126/Science.1091496 |
0.571 |
|
| 2004 |
Moncalian G, Lengsfeld B, Bhaskara V, Hopfner KP, Karcher A, Alden E, Tainer JA, Paull TT. The rad50 signature motif: essential to ATP binding and biological function. Journal of Molecular Biology. 335: 937-51. PMID 14698290 DOI: 10.1016/J.Jmb.2003.11.026 |
0.762 |
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| 2004 |
Costanzo V, Paull TT, Gottesman M, Gautier J. Erratum: Mre11 assembles linear DNA fragments into DNA damage signaling complexes (PLoS Biology 2, 5 DOI: 10.1371/journal.pbio.0020110)) Plos Biology. 2. DOI: 10.1371/Journal.Pbio.0020229 |
0.631 |
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| 2003 |
Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT. Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes. The Journal of Biological Chemistry. 278: 45171-81. PMID 12966088 DOI: 10.1074/Jbc.M308705200 |
0.834 |
|
| 2001 |
Paull TT. New glimpses of an old machine Cell. 107: 563-565. PMID 11733056 DOI: 10.1016/S0092-8674(01)00591-8 |
0.66 |
|
| 2001 |
Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M. Direct DNA binding by Brca1 Proceedings of the National Academy of Sciences of the United States of America. 98: 6086-6091. PMID 11353843 DOI: 10.1073/Pnas.111125998 |
0.698 |
|
| 2000 |
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Current Biology. 10: 886-895. PMID 10959836 DOI: 10.1016/S0960-9822(00)00610-2 |
0.596 |
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| 2000 |
Paull TT, Gellert M. A mechanistic basis for Mre11-directed DNA joining at microhomologies Proceedings of the National Academy of Sciences of the United States of America. 97: 6409-6414. PMID 10823903 DOI: 10.1073/Pnas.110144297 |
0.626 |
|
| 1999 |
Gellert M, Hesse JE, Hiom K, Melek M, Modesti M, Paull TT, Ramsden DA, Van Gent DC. V(D)J recombination: Links to transposition and double-strand break repair Cold Spring Harbor Symposia On Quantitative Biology. 64: 161-167. PMID 11232281 DOI: 10.1101/Sqb.1999.64.161 |
0.303 |
|
| 1999 |
Paull TT, Gellert M. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex Genes and Development. 13: 1276-1288. PMID 10346816 DOI: 10.1101/Gad.13.10.1276 |
0.658 |
|
| 1998 |
Paull TT, Gellert M. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks Molecular Cell. 1: 969-979. PMID 9651580 DOI: 10.1016/S1097-2765(00)80097-0 |
0.62 |
|
| 1997 |
Ramsden DA, Paull TT, Gellert M. Cell-free V(D)J recombination Nature. 388: 488-491. PMID 9242409 DOI: 10.1038/41351 |
0.333 |
|
| 1997 |
Van Gent DC, Hiom K, Paull TT, Gellert M. Stimulation of V(D)J cleavage by high mobility group proteins Embo Journal. 16: 2665-2670. PMID 9184213 DOI: 10.1093/Emboj/16.10.2665 |
0.371 |
|
| 1996 |
Paull TT, Carey M, Johnson RC. Yeast HMG proteins NHP6A/B potentiate promoter-specific transcriptional activation in vivo and assembly of preinitiation complexes in vitro Genes and Development. 10: 2769-2781. PMID 8946917 DOI: 10.1101/Gad.10.21.2769 |
0.461 |
|
| 1995 |
Paull TT, Johnson RC. DNA looping by Saccharomyces cerevisiae high mobility group proteins NHP6A/B: Consequences for nucleoprotein complex assembly and chromatin condensation Journal of Biological Chemistry. 270: 8744-8754. PMID 7721780 DOI: 10.1074/jbc.270.15.8744 |
0.59 |
|
| 1994 |
Paull TT, Haykinson MJ, Johnson RC. HU and functional analogs in eukaryotes promote Hin invertasome assembly Biochimie. 76: 992-1004. PMID 7748943 DOI: 10.1016/0300-9084(94)90024-8 |
0.524 |
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| 1993 |
Paull TT, Haykinson MJ, Johnson RC. The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures Genes and Development. 7: 1521-1534. PMID 8339930 DOI: 10.1101/Gad.7.8.1521 |
0.638 |
|
| 1992 |
Mahbubani HM, Paull T, Eider JK, Blow JJ. DNA replication initiates at multiple sites on plasmid DNA in xenopus egg extracts Nucleic Acids Research. 20: 1457-1462. PMID 1579437 DOI: 10.1093/Nar/20.7.1457 |
0.582 |
|
| 1988 |
Fleming JE, Paull TT. Semi-dry electroblotting of DNA Biotechniques. 6. PMID 2856198 |
0.343 |
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