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Judy L. Bolton - Publications

Affiliations: 
University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Toxicology, Biochemistry
Website:
http://foto.pharm.uic.edu/mcp/people/bolton_jl.html

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hitzman RT, Dunlap TL, Howell CE, Chen SN, Vollmer G, Pauli GF, Bolton JL, Dietz BM. 6-Prenylnaringenin from Hops Disrupts ERα-mediated Downregulation of CYP1A1 to Facilitate Estrogen Detoxification. Chemical Research in Toxicology. PMID 32986415 DOI: 10.1021/acs.chemrestox.0c00194  0.393
2020 Mbachu OC, Howell C, Simmler C, Malca Garcia GR, Skowron KJ, Dong H, Ellis SG, Hitzman RT, Hajirahimkhan A, Chen SN, Nikolic D, Moore TW, Vollmer G, Pauli GF, Bolton JL, et al. SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents. Journal of Agricultural and Food Chemistry. PMID 32945668 DOI: 10.1021/Acs.Jafc.0C03526  0.322
2019 Bolton JL, Dunlap TL, Hajirahimkhan DA, Mbachu OC, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM. The Multiple Biological Targets of Hops and Bioactive Compounds. Chemical Research in Toxicology. PMID 30608650 DOI: 10.1021/Acs.Chemrestox.8B00345  0.409
2018 Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats. Cancer Prevention Research (Philadelphia, Pa.). PMID 30287522 DOI: 10.1158/1940-6207.Capr-18-0178  0.413
2018 Bolton JL, Dunlap TL, Dietz BM. Formation and biological targets of botanical o-quinones. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30063944 DOI: 10.1016/J.Fct.2018.07.050  0.345
2018 Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. Journal of Natural Products. PMID 29641206 DOI: 10.1021/Acs.Jnatprod.7B01070  0.436
2017 Dunlap TL, Howell CE, Mukand N, Chen SN, Pauli GF, Dietz BM, Bolton JL. Red clover aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) agonists enhance genotoxic estrogen metabolism. Chemical Research in Toxicology. PMID 28985473 DOI: 10.1021/Acs.Chemrestox.7B00237  0.465
2017 Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. The Journal of Steroid Biochemistry and Molecular Biology. PMID 28964928 DOI: 10.1016/J.Jsbmb.2017.09.020  0.363
2017 Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. Journal of Natural Products. PMID 28812892 DOI: 10.1021/Acs.Jnatprod.7B00284  0.391
2016 Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacological Reviews. 68: 1026-1073. PMID 27677719 DOI: 10.1124/Pr.115.010843  0.328
2016 Bolton JL, Dunlap TL. Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects. Chemical Research in Toxicology. PMID 27617882 DOI: 10.1021/Acs.Chemrestox.6B00256  0.405
2016 Wang S, Dunlap TL, Howell CE, Mbachu OC, Rue EA, Phansalkar RS, Chen SN, Pauli GF, Dietz BM, Bolton JL. Hop (Humulus lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation. Chemical Research in Toxicology. PMID 27269377 DOI: 10.1021/Acs.Chemrestox.6B00112  0.417
2015 Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolic D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women's health: differential effects of the Michael acceptors isoliquiritigenin and licochalcone A. Chemical Research in Toxicology. PMID 26473469 DOI: 10.1021/Acs.Chemrestox.5B00310  0.318
2015 Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL. Differential effects of Glycyrrhiza species on genotoxic estrogen metabolism: licochalcone A downregulates P450 1B1 whereas isoliquiritigenin stimulates. Chemical Research in Toxicology. PMID 26134484 DOI: 10.1021/Acs.Chemrestox.5B00157  0.414
2015 Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, ... ... Bolton JL, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 518: 197-206. PMID 25673413 DOI: 10.1038/Nature14177  0.503
2015 Chen S, Friesen J, McAlpine J, Overk C, Bolton J, Pauli G. Rebiogram enhances the search of bioactive natural products Planta Medica. 81. DOI: 10.1055/S-0035-1556308  0.622
2015 Dunlap T, Wang S, Simmler C, Chen S, Pauli G, Dietz B, Bolton J. Licochalcone A and isoliquiritigenin from Licorice species differentially modulate P450 1B1-mediated estrogen metabolism Planta Medica. 81. DOI: 10.1055/S-0035-1556258  0.307
2014 Bolton JL. Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection? Current Organic Chemistry. 18: 61-69. PMID 25346613 DOI: 10.2174/138527281801140121123046  0.481
2014 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, ... ... Bolton JL, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46: 1173-86. PMID 25282103 DOI: 10.1038/Ng.3097  0.519
2014 van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen SN, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Molecular Nutrition & Food Research. 58: 1962-9. PMID 25045111 DOI: 10.1002/Mnfr.201400245  0.314
2014 Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement. Biomedical Chromatography : Bmc. 28: 729-34. PMID 24861737 DOI: 10.1002/Bmc.3177  0.363
2014 Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR. SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15. PMID 24598415 DOI: 10.1158/1940-6207.Capr-13-0296  0.477
2013 Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. Plos One. 8: e67947. PMID 23874474 DOI: 10.1371/Journal.Pone.0067947  0.453
2013 Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, ... ... Bolton JL, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Plos Genetics. 9: e1003500. PMID 23754948 DOI: 10.1371/Journal.Pgen.1003500  0.505
2013 Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Molecular Nutrition & Food Research. 57: 1055-66. PMID 23512484 DOI: 10.1002/Mnfr.201200534  0.38
2013 Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. Journal of Agricultural and Food Chemistry. 61: 2146-57. PMID 23427769 DOI: 10.1021/Jf304445P  0.308
2013 Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Medica. 79: 538-53. PMID 23408273 DOI: 10.1055/S-0032-1328187  0.368
2012 Snelten CS, Dietz B, Bolton JL. Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health. Drug Discovery Today. Disease Mechanisms. 9. PMID 24223609 DOI: 10.1016/J.Ddmec.2012.11.001  0.417
2012 Michalsen BT, Gherezghiher TB, Choi J, Chandrasena RE, Qin Z, Thatcher GR, Bolton JL. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol. Chemical Research in Toxicology. 25: 1472-83. PMID 22642258 DOI: 10.1021/Tx300142H  0.471
2012 Toh MF, Sohn J, Chen SN, Yao P, Bolton JL, Burdette JE. Biological characterization of non-steroidal progestins from botanicals used for women's health. Steroids. 77: 765-73. PMID 22484153 DOI: 10.1016/J.Steroids.2012.03.013  0.656
2012 Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chemico-Biological Interactions. 196: 1-10. PMID 22290292 DOI: 10.1016/J.Cbi.2012.01.004  0.439
2012 Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prevention Research (Philadelphia, Pa.). 5: 73-81. PMID 21997247 DOI: 10.1158/1940-6207.Capr-11-0348  0.488
2012 Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF. Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 83: 18-32. PMID 21907766 DOI: 10.1016/J.Fitote.2011.08.017  0.343
2011 Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/Journal.Pone.0027876  0.469
2011 Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 24: 2153-66. PMID 21910479 DOI: 10.1021/Tx200294C  0.372
2011 Dietz BM, Bolton JL. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chemico-Biological Interactions. 192: 72-80. PMID 20970412 DOI: 10.1016/J.Cbi.2010.10.007  0.317
2011 Hemachandra L, Chandrasena R, Dietz B, Chen S, Pauli G, Farnsworth N, Thatcher G, Bolton J. Hops (Humulus lupulus) Inhibits Estrogen Metabolism in Non-tumorigenic Human Breast Epithelial Cells (MCF-10A cells) Planta Medica. 77. DOI: 10.1055/S-0031-1273673  0.365
2011 Bolton JL. Mechanisms of estrogen carcinogenesis: Modulation by botanical natural products Current Cancer Research. 6: 75-93. DOI: 10.1007/978-1-61737-995-6_4  0.389
2010 Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/Tx100129H  0.831
2010 Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73. PMID 20509668 DOI: 10.1021/Tx1001282  0.74
2010 van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen SN, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, et al. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh. Clinical Pharmacology and Therapeutics. 87: 219-25. PMID 20032972 DOI: 10.1038/Clpt.2009.251  0.324
2010 Dietz BM, Hagos GK, Yao P, Lantvit DD, Chen S, Goedecke T, Farnsworth NR, Pauli GF, Bolton JL. Abstract B67: Influence of black cohosh and its isolated triterpenes on tamoxifen‐induced endometrial cell proliferation Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B67  0.414
2009 Peng KW, Wang H, Qin Z, Wijewickrama GT, Lu M, Wang Z, Bolton JL, Thatcher GR. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49. PMID 19839584 DOI: 10.1021/Cb9001848  0.775
2009 Zhang N, Ding S, Kolbanovskiy A, Shastry A, Kuzmin VA, Bolton JL, Patel DJ, Broyde S, Geacintov NE. NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms. Biochemistry. 48: 7098-109. PMID 19527068 DOI: 10.1021/Bi9006429  0.322
2009 Wang Z, Edirisinghe P, Sohn J, Qin Z, Geacintov NE, Thatcher GR, Bolton JL. Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chemical Research in Toxicology. 22: 1129-36. PMID 19368368 DOI: 10.1021/Tx900063G  0.658
2009 Yu B, Qin Z, Wijewickrama GT, Edirisinghe P, Bolton JL, Thatcher GR. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjugate Chemistry. 20: 728-41. PMID 19301905 DOI: 10.1021/Bc800435M  0.621
2009 Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR. Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42. PMID 19158089 DOI: 10.1074/Jbc.M807860200  0.757
2009 Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochemical Analysis : Pca. 20: 120-33. PMID 19140115 DOI: 10.1002/Pca.1106  0.663
2009 Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/Dmd.108.023408  0.707
2009 Molloy M, Thatcher G, Bolton J, Tonetti D. 2-(4-Hydroxyphenyl)-Benzo[b]thiophen-6-ol, an Estrogen-Like Compound, Induces Apoptosis in T47D/PKCα Breast Cancer Cells. Cancer Research. 69: 5140-5140. DOI: 10.1158/0008-5472.Sabcs-09-5140  0.413
2008 Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. Journal of Agricultural and Food Chemistry. 56: 11718-26. PMID 19049296 DOI: 10.1021/Jf803298Z  0.676
2008 Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. Chemical Research in Toxicology. 21: 1939-48. PMID 18808158 DOI: 10.1021/Tx8001274  0.39
2008 Ding S, Wang Y, Kolbanovskiy A, Durandin A, Bolton JL, van Breemen RB, Broyde S, Geacintov NE. Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry. Chemical Research in Toxicology. 21: 1739-48. PMID 18680315 DOI: 10.1021/Tx800095F  0.339
2008 Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chemico-Biological Interactions. 176: 30-9. PMID 18619951 DOI: 10.1016/J.Cbi.2008.06.005  0.679
2008 Chandrasena RE, Edirisinghe PD, Bolton JL, Thatcher GR. Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chemical Research in Toxicology. 21: 1324-9. PMID 18588320 DOI: 10.1021/Tx8000797  0.471
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  0.821
2008 Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Combinatorial Chemistry & High Throughput Screening. 11: 283-93. PMID 18473738 DOI: 10.2174/138620708784246022  0.726
2008 Bolton JL, Thatcher GR. Potential mechanisms of estrogen quinone carcinogenesis. Chemical Research in Toxicology. 21: 93-101. PMID 18052105 DOI: 10.1021/Tx700191P  0.514
2008 Dietz B, Hagos G, Guo J, Main M, Lantvit D, Farnsworth N, Pauli G, Breemen Rv, Bolton J. Abstract A43: Hops (humulus lupulus) induce detoxification enzymes in vivo Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-A43  0.394
2008 Imai A, Yao P, Overk C, Bolton J, Nikolic D, van Breemen R, Pauli G. Phytochemical Investigation of the Estrogenic Aerial Parts of Cimicifuga racemosa (L.) Nutt(Ranunculaceae) Planta Medica. 74. DOI: 10.1055/S-2008-1075241  0.655
2007 Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.Mct-07-0268  0.791
2007 Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/Cmdc.200700104  0.774
2007 Liu H, Qin Z, Thatcher GR, Bolton JL. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene. Chemical Research in Toxicology. 20: 1676-84. PMID 17630709 DOI: 10.1021/Tx7001367  0.454
2007 Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/En.2006-1568  0.822
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/Jm070079J  0.416
2007 Dietz B, Bolton JL. Botanical dietary supplements gone bad. Chemical Research in Toxicology. 20: 586-90. PMID 17362034 DOI: 10.1021/Tx7000527  0.301
2006 Dowers TS, Qin ZH, Thatcher GR, Bolton JL. Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chemical Research in Toxicology. 19: 1125-37. PMID 16978016 DOI: 10.1021/Tx060126V  0.324
2006 Liu H, Bolton JL, Thatcher GR. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator. Chemical Research in Toxicology. 19: 779-87. PMID 16780356 DOI: 10.1021/Tx050326R  0.446
2006 Cuendet M, Bolton JL. Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest. Chemico-Biological Interactions. 161: 271-8. PMID 16730688 DOI: 10.1016/J.Cbi.2006.04.004  0.413
2006 Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. Journal of Natural Products. 69: 536-41. PMID 16643021 DOI: 10.1021/Np050301S  0.32
2006 Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. Journal of Alternative and Complementary Medicine (New York, N.Y.). 12: 133-9. PMID 16566672 DOI: 10.1089/Acm.2006.12.133  0.767
2006 Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. Journal of Natural Products. 69: 432-5. PMID 16562853 DOI: 10.1021/Np058114H  0.327
2006 Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. Journal of Agricultural and Food Chemistry. 54: 1277-82. PMID 16478248 DOI: 10.1021/Jf052927U  0.706
2006 Bolton JL. Chapter 1 Bioactivation of Estrogens to Toxic Quinones Advances in Molecular Toxicology. 1: 1-23. DOI: 10.1016/S1872-0854(06)01001-0  0.483
2005 Kolbanovskiy A, Kuzmin V, Shastry A, Kolbanovskaya M, Chen D, Chang M, Bolton JL, Geacintov NE. Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin. Chemical Research in Toxicology. 18: 1737-47. PMID 16300383 DOI: 10.1021/Tx050190X  0.674
2005 Li Y, Yang X, van Breemen RB, Bolton JL. Characterization of two new variants of human catechol O-methyltransferase in vitro. Cancer Letters. 230: 81-9. PMID 16253764 DOI: 10.1016/J.Canlet.2004.12.022  0.372
2005 Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Analytical Chemistry. 77: 6407-14. PMID 16194107 DOI: 10.1021/Ac050892R  0.375
2005 Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chemical Research in Toxicology. 18: 1485-96. PMID 16167842 DOI: 10.1021/Tx0501738  0.526
2005 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chemical Research in Toxicology. 18: 1296-305. PMID 16097803 DOI: 10.1021/Tx050058X  0.428
2005 Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). Journal of Agricultural and Food Chemistry. 53: 6246-53. PMID 16076101 DOI: 10.1021/Jf050448P  0.726
2005 Li Y, Yang X, Chang M, Yager JD, van Breemen RB, Bolton JL. Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase. Chemico-Biological Interactions. 152: 151-63. PMID 15840388 DOI: 10.1016/J.Cbi.2005.03.001  0.703
2005 Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/Tx0497752  0.599
2005 Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/Tx049776U  0.604
2005 Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. Journal of the American Society For Mass Spectrometry. 16: 271-9. PMID 15694777 DOI: 10.1016/J.Jasms.2004.11.002  0.579
2004 Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. Estrogens and congeners from spent hops (Humulus lupulus). Journal of Natural Products. 67: 2024-32. PMID 15620245 DOI: 10.1021/Np049783I  0.755
2004 Li Y, Yao J, Chang M, Cuendet M, Bolton JL. Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin. Toxicology Letters. 154: 225-33. PMID 15501614 DOI: 10.1016/J.Toxlet.2004.08.006  0.735
2004 Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher GR, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chemical Research in Toxicology. 17: 879-88. PMID 15257612 DOI: 10.1021/Tx0342722  0.729
2004 Piersen CE, Booth NL, Sun Y, Liang W, Burdette JE, van Breemen RB, Geller SE, Gu C, Banuvar S, Shulman LP, Bolton JL, Farnsworth NR. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. Current Medicinal Chemistry. 11: 1361-74. PMID 15180571 DOI: 10.2174/0929867043365134  0.56
2004 Cuendet M, Liu X, Pisha E, Li Y, Yao J, Yu L, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression. Mutation Research. 550: 109-21. PMID 15135645 DOI: 10.1016/J.Mrfmmm.2004.02.005  0.555
2004 Li Y, Yao J, Chang M, Nikolic D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chemical Research in Toxicology. 17: 512-20. PMID 15089093 DOI: 10.1021/Tx0342464  0.736
2004 Bolton JL, Yu L, Thatcher GR. Quinoids formed from estrogens and antiestrogens. Methods in Enzymology. 378: 110-23. PMID 15038960 DOI: 10.1016/S0076-6879(04)78006-4  0.471
2004 Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 11: 18-23. PMID 14974442 DOI: 10.1078/0944-7113-00331  0.703
2003 Toader V, Xu X, Nicolescu A, Yu L, Bolton JL, Thatcher GR. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species. Chemical Research in Toxicology. 16: 1264-76. PMID 14565768 DOI: 10.1021/Tx025641H  0.43
2003 Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. Journal of Agricultural and Food Chemistry. 51: 5661-70. PMID 12952416 DOI: 10.1021/Jf034264R  0.641
2003 Liu X, Pisha E, Tonetti DA, Yao D, Li Y, Yao J, Burdette JE, Bolton JL. Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites. Chemical Research in Toxicology. 16: 832-7. PMID 12870885 DOI: 10.1021/Tx030004S  0.739
2003 Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chemical Research in Toxicology. 16: 741-9. PMID 12807357 DOI: 10.1021/Tx030001F  0.817
2003 Johnson BM, Qiu SX, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB. Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). Chemical Research in Toxicology. 16: 733-40. PMID 12807356 DOI: 10.1021/Tx020113R  0.757
2003 Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, Van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chemical Research in Toxicology. 16: 668-75. PMID 12755597 DOI: 10.1021/Tx0340549  0.772
2002 Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. Journal of Agricultural and Food Chemistry. 50: 7022-8. PMID 12428954 DOI: 10.1021/Jf020725H  0.67
2002 Bolton JL. Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology. 177: 55-65. PMID 12126795 DOI: 10.1016/S0300-483X(02)00195-6  0.456
2002 Yao J, Chang M, Li Y, Pisha E, Liu X, Yao D, Elguindi EC, Blond SY, Bolton JL. Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1. Chemical Research in Toxicology. 15: 935-42. PMID 12119004 DOI: 10.1021/Tx020018I  0.774
2002 Liu X, Yao J, Pisha E, Yang Y, Hua Y, van Breemen RB, Bolton JL. Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha. Chemical Research in Toxicology. 15: 512-9. PMID 11952337 DOI: 10.1021/Tx0101649  0.611
2002 Geun Shin Y, Bolton JL, van Breemen RB. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Combinatorial Chemistry & High Throughput Screening. 5: 59-64. PMID 11860340 DOI: 10.2174/1386207023330633  0.312
2002 Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP, Hedayat S, Van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. The Journal of Nutrition. 132: 27-30. PMID 11773503 DOI: 10.1093/Jn/132.1.27  0.662
2001 Bolton JL, Chang M. Quinoids as reactive intermediates in estrogen carcinogenesis. Advances in Experimental Medicine and Biology. 500: 497-507. PMID 11764987 DOI: 10.1007/978-1-4615-0667-6_75  0.697
2001 Zhang F, Swanson SM, van Breemen RB, Liu X, Yang Y, Gu C, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chemical Research in Toxicology. 14: 1654-9. PMID 11743748 DOI: 10.1021/Tx010158C  0.762
2001 Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones. Chemical Research in Toxicology. 14: 1643-53. PMID 11743747 DOI: 10.1021/Tx010137I  0.718
2001 Zhang F, Yao D, Hua Y, van Breemen RB, Bolton JL. Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone. Chemical Research in Toxicology. 14: 754-63. PMID 11409947 DOI: 10.1021/Tx010049Y  0.761
2001 Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Journal of Agricultural and Food Chemistry. 49: 2472-9. PMID 11368622 DOI: 10.1021/Jf0014157  0.702
2001 Spink DC, Zhang F, Hussain MM, Katz BH, Liu X, Hilker DR, Bolton JL. Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chemical Research in Toxicology. 14: 572-81. PMID 11368557 DOI: 10.1021/Tx000219R  0.741
2001 Fan PW, Bolton JL. Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 891-6. PMID 11353759  0.694
2001 Chang M, Shin YG, van Breemen RB, Blond SY, Bolton JL. Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. Biochemistry. 40: 4811-20. PMID 11294649 DOI: 10.1021/Bi002513O  0.681
2001 Pisha E, Lui X, Constantinou AI, Bolton JL. Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro Chemical Research in Toxicology. 14: 82-90. PMID 11170511 DOI: 10.1021/Tx000168Y  0.41
2001 Hua Y, Wainhaus SB, Yang Y, Shen L, Xiong Y, Xu X, Zhang F, Bolton JL, van Breemen RB. Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides. Journal of the American Society For Mass Spectrometry. 12: 80-7. PMID 11142363 DOI: 10.1016/S1044-0305(00)00191-4  0.663
2000 Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. European Journal of Cancer (Oxford, England : 1990). 36: 2146-56. PMID 11044654 DOI: 10.1016/S0959-8049(00)00300-2  0.313
2000 Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chemical Research in Toxicology. 13: 342-50. PMID 10813650 DOI: 10.1021/Tx990186J  0.77
2000 Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ. Role of quinones in toxicology Chemical Research in Toxicology. 13: 135-160. PMID 10725110 DOI: 10.1021/Tx9902082  0.393
2000 Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Chemical Research in Toxicology. 13: 53-62. PMID 10649967 DOI: 10.1021/Tx990145N  0.822
2000 Fan PW, Zhang F, Bolton JL. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides. Chemical Research in Toxicology. 13: 45-52. PMID 10649966 DOI: 10.1021/Tx990144V  0.811
1999 Chang M, Bolton JL, Blond SY. Expression and purification of hexahistidine-tagged human glutathione S-transferase P1-1 in Escherichia coli. Protein Expression and Purification. 17: 443-8. PMID 10600464 DOI: 10.1006/Prep.1999.1149  0.671
1999 Nikolic D, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Combinatorial Chemistry & High Throughput Screening. 2: 165-75. PMID 10420970  0.649
1999 Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 12: 204-13. PMID 10027800 DOI: 10.1021/Tx980217V  0.756
1999 Zhang F, Bolton JL. Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin. Chemical Research in Toxicology. 12: 200-3. PMID 10027799 DOI: 10.1021/Tx980189G  0.733
1998 Bolton JL, Pisha E, Zhang F, Qiu S. Role of quinoids in estrogen carcinogenesis. Chemical Research in Toxicology. 11: 1113-27. PMID 9778307 DOI: 10.1021/Tx9801007  0.688
1998 Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chemical Research in Toxicology. 11: 1105-11. PMID 9760286 DOI: 10.1021/Tx980083L  0.701
1998 Chang M, Zhang F, Shen L, Pauss N, Alam I, van Breemen RB, Blond SY, Bolton JL. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens. Chemical Research in Toxicology. 11: 758-65. PMID 9671538 DOI: 10.1021/Tx9702190  0.813
1998 Sugumaran M, Bolton JL. Laccase-and not tyrosinase-is the enzyme responsible for quinone methide production from 2,6-dimethoxy-4-allyl phenol Archives of Biochemistry and Biophysics. 353: 207-212. PMID 9606954 DOI: 10.1006/Abbi.1998.0653  0.389
1998 Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikolic D, Bolton JL. Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chemical Research in Toxicology. 11: 94-101. PMID 9511900 DOI: 10.1021/Tx970181R  0.695
1998 Sanchez C, Shibutani S, Dasaradhi L, Bolton JL, Fan PW, McClelland RA. Lifetime and reactivity of an ultimate tamoxifen carcinogen: The tamoxifen carbocation [1] Journal of the American Chemical Society. 120: 13513-13514. DOI: 10.1021/Ja982701Q  0.745
1997 Bolton JL, Turnipseed SB, Thompson JA. Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: Studies utilizing amino acid and peptide models Chemico-Biological Interactions. 107: 185-200. PMID 9448752 DOI: 10.1016/S0009-2797(97)00079-3  0.305
1997 Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, Van Breemen RB, Pezzuto JM. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells Chemico-Biological Interactions. 106: 133-148. PMID 9366899 DOI: 10.1016/S0009-2797(97)00066-5  0.378
1997 Ramakrishna KV, Fan PW, Boyer CS, Dalvie D, Bolton JL. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen. Chemical Research in Toxicology. 10: 887-94. PMID 9282838 DOI: 10.1021/tx970060r  0.655
1997 Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, Van Breemen RB, Bolton JL. Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity Carcinogenesis. 18: 1093-1101. PMID 9163701 DOI: 10.1093/Carcin/18.5.1093  0.441
1997 Krol ES, Bolton JL. Oxidation of 4-alkylphenols and catechols by tyrosinase: Ortho-substituents alter the mechanism of quinoid formation Chemico-Biological Interactions. 104: 11-27. PMID 9158692 DOI: 10.1016/S0009-2797(97)03763-0  0.364
1997 McCracken PG, Bolton JL, Thatcher GRJ. Covalent Modification of Proteins and Peptides by the Quinone Methide from 2-tert-Butyl-4,6-dimethylphenol: Selectivity and Reactivity with Respect to Competitive Hydration Journal of Organic Chemistry. 62: 1820-1825. DOI: 10.1021/Jo962088Y  0.33
1996 Lewis MA, Yoerg DG, Bolton JL, Thompson JA. Alkylation of 2'-deoxynucleosides and DNA by quinone methides derived from 2,6-Di-tert-butyl-4-methylphenol Chemical Research in Toxicology. 9: 1368-1374. PMID 8951242 DOI: 10.1021/Tx960115+  0.333
1996 Bolton JL, Wu HM, Hu LQ. Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide Chemical Research in Toxicology. 9: 109-113. PMID 8924578 DOI: 10.1021/Tx9500888  0.306
1996 Iverson SL, Shen L, Anlar N, Bolton JL. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes Chemical Research in Toxicology. 9: 492-499. PMID 8839054 DOI: 10.1021/Tx950178C  0.405
1996 Bolton JL, Shen L. p-quinone methides are the major decomposition products of catechol estrogen o-quinones Carcinogenesis. 17: 925-929. PMID 8640939 DOI: 10.1093/Carcin/17.5.925  0.431
1995 Bolton JL, Comeau E, Vukomanovic V. The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended π-conjugation dramatically stabilizes the quinone methide formed from eugenol Chemico-Biological Interactions. 95: 279-290. PMID 7728898 DOI: 10.1016/0009-2797(94)03566-Q  0.363
1995 Dowsley TF, Forkert PG, Benesch LA, Bolton JL. Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene Chemico-Biological Interactions. 95: 227-244. PMID 7728894 DOI: 10.1016/0009-2797(94)03563-N  0.372
1995 Sugumaran M, Bolton J. Direct Evidence for Quinone-Quinone Methide Tautomerism during Tyrosinase Catalyzed Oxidation of 4-Allylcatechol Biochemical and Biophysical Research Communications. 213: 469-474. PMID 7646501 DOI: 10.1006/Bbrc.1995.2155  0.356
1995 Thompson DC, Perera K, Krol ES, Bolton JL. O-methoxy-4-alkylphenols that form quinone methides of intermediate reactivity are the most toxic in rat liver slices Chemical Research in Toxicology. 8: 323-327. PMID 7578916 DOI: 10.1021/Tx00045A001  0.378
1995 Iverson SL, Hu LQ, Vukomanovic V, Bolton JL. The influence of the p-alkyl substituent on the isomerization of o-quinones to p-quinone methides: Potential bioactivation mechanism for catechols Chemical Research in Toxicology. 8: 537-544. PMID 7548733 DOI: 10.1021/Tx00046A007  0.36
1994 Bolton JL, Acay NM, Vukomanovic V. Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: Potential bioactivation mechanism for the hepatocarcinogen safrole Chemical Research in Toxicology. 7: 443-450. PMID 8075378 DOI: 10.1021/Tx00039A024  0.396
1993 Bolton JL, Thompson JA, Allentoff AJ, Miley FB, Malkinson AM. Metabolic Activation of Butylated Hydroxytoluene by Mouse Bronchiolar Clara Cells Toxicology and Applied Pharmacology. 123: 43-49. PMID 8236260 DOI: 10.1006/Taap.1993.1219  0.374
1992 Bolton JL, Valerio LG, Thompson JA. The enzymatic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes Chemical Research in Toxicology. 5: 816-822. PMID 1489934 DOI: 10.1021/Tx00030A014  0.353
1991 Thompson JA, Bolton JL, Schullek KM, Sevestre H. Bioactivation of 2,6-di-tert-butyl-4-methyl phenol (BHT) and hydroxylated analogues to toxic quinoid metabolites Advances in Experimental Medicine and Biology. 283: 393-398. PMID 2069012 DOI: 10.1007/978-1-4684-5877-0_52  0.329
1991 Thompson JA, Bolton JL, Malkinson AM. Relationship between the metabolism of butylated hydroxytoluene (BHT) and lung tumor promotion in mice Experimental Lung Research. 17: 439-453. PMID 2050043 DOI: 10.3109/01902149109064431  0.308
1990 Bolton JL, Sevestre H, Ibe BO, Thompson JA. Formation and reactivity of alternative quinone methides from butylated hydroxytoluene: possible explanation for species-specific pneumotoxicity. Chemical Research in Toxicology. 3: 65-70. PMID 2131827 DOI: 10.1021/Tx00013A011  0.353
1989 Bolton JL, McClelland RA. Azide ion trapping and lifetime in aqueous solution of a primary carbenium ion stabilized by a 2-imidazoyl ring Canadian Journal of Chemistry. 67: 1139-1143. DOI: 10.1139/V89-171  0.523
1989 Bolton JL, McClelland RA. Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxyamino)imidazoles Journal of the American Chemical Society. 111: 8172-8181. DOI: 10.1021/Ja00203A018  0.565
1988 Bolton JL, Peterson MR, McClelland RA. Experimental and theoretical investigation of C-nitroso rotation in 2-nitrosoimidazoles Canadian Journal of Chemistry. 66: 3044-3049. DOI: 10.1139/V88-471  0.518
1988 Bolton JL, McClelland RA. Theoretical studies of imidazole nitrenium and carbenium ions Journal of Molecular Structure: Theochem. 165: 379-389. DOI: 10.1016/0166-1280(88)87034-9  0.514
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