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173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bolton JL, Dunlap TL, Hajirahimkhan A, Mbachu O, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM. Correction to The Multiple Biological Targets of Hops and Bioactive Compounds. Chemical Research in Toxicology. PMID 31392882 DOI: 10.1021/acs.chemrestox.9b00300  0.88
2019 Bolton JL, Dunlap TL, Hajirahimkhan DA, Mbachu OC, Chen SN, Chadwick L, Nikolic D, van Breemen RB, Pauli GF, Dietz BM. The Multiple Biological Targets of Hops and Bioactive Compounds. Chemical Research in Toxicology. PMID 30608650 DOI: 10.1021/acs.chemrestox.8b00345  0.88
2018 Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Evidence for Chemopreventive and resilience activity of licorice: Glycyrrhiza glabra and G. inflata extracts modulate estrogen metabolism in ACI rats. Cancer Prevention Research (Philadelphia, Pa.). PMID 30287522 DOI: 10.1158/1940-6207.CAPR-18-0178  0.88
2018 Bolton JL, Dunlap TL, Dietz BM. Formation and biological targets of botanical o-quinones. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30063944 DOI: 10.1016/j.fct.2018.07.050  0.64
2018 Hajirahimkhan A, Mbachu O, Simmler C, Ellis SG, Dong H, Nikolic D, Lankin DC, van Breemen RB, Chen SN, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. Journal of Natural Products. PMID 29641206 DOI: 10.1021/acs.jnatprod.7b01070  0.88
2017 Dunlap TL, Howell CE, Mukand N, Chen SN, Pauli GF, Dietz BM, Bolton JL. Red clover aryl hydrocarbon receptor (AhR) and estrogen receptor (ER) agonists enhance genotoxic estrogen metabolism. Chemical Research in Toxicology. PMID 28985473 DOI: 10.1021/acs.chemrestox.7b00237  0.64
2017 Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen SN, van Breemen RB, Nikolic D, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats. The Journal of Steroid Biochemistry and Molecular Biology. PMID 28964928 DOI: 10.1016/j.jsbmb.2017.09.020  0.88
2017 Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen SN, Dietz BM, van Breemen RB, Zierau O. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 34: 50-58. PMID 28899509 DOI: 10.1016/j.phymed.2017.08.001  0.88
2017 Dietz BM, Chen SN, Alvarenga RFR, Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women's Health. Journal of Natural Products. PMID 28812892 DOI: 10.1021/acs.jnatprod.7b00284  0.88
2016 Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF. Botanical Integrity: Part 2: Traditional and Modern Analytical Approaches. Herbalgram. 109: 60-64. PMID 30287984  0.88
2016 Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacological Reviews. 68: 1026-1073. PMID 27677719 DOI: 10.1124/pr.115.010843  0.64
2016 Bolton JL, Dunlap TL. Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects. Chemical Research in Toxicology. PMID 27617882 DOI: 10.1021/acs.chemrestox.6b00256  0.64
2016 Wang S, Dunlap TL, Howell CE, Mbachu OC, Rue EA, Phansalkar RS, Chen SN, Pauli GF, Dietz BM, Bolton JL. Hop (Humulus lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation. Chemical Research in Toxicology. PMID 27269377 DOI: 10.1021/acs.chemrestox.6b00112  1
2015 Simmler C, Chen SN, Anderson J, Lankin DC, Phansalkar R, Krause E, Dietz B, Bolton JL, Nikolic D, van Breemen RB, Pauli GF. Botanical Integrity: The Importance of the Integration of Chemical, Biological, and Botanical Analyses, and the Role of DNA Barcoding. Herbalgram. 106: 58-60. PMID 30287983  0.88
2015 Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolic D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL. Induction of NAD(P)H:quinone oxidoreductase 1 (NQO1) by Glycyrrhiza species used for women's health: differential effects of the Michael acceptors isoliquiritigenin and licochalcone A. Chemical Research in Toxicology. PMID 26473469 DOI: 10.1021/acs.chemrestox.5b00310  1
2015 Dunlap TL, Wang S, Simmler C, Chen SN, Pauli GF, Dietz BM, Bolton JL. Differential effects of Glycyrrhiza species on genotoxic estrogen metabolism: licochalcone A downregulates P450 1B1 whereas isoliquiritigenin stimulates. Chemical Research in Toxicology. PMID 26134484 DOI: 10.1021/acs.chemrestox.5b00157  1
2014 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, ... ... Bolton JL, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46: 1173-86. PMID 25282103 DOI: 10.1038/ng.3097  0.72
2014 van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF, Chen SN, Dietz BM, Bolton JL, Pauli GF, Krause E, Viana M, Nikolic D. Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops. Molecular Nutrition & Food Research. 58: 1962-9. PMID 25045111 DOI: 10.1002/mnfr.201400245  1
2014 Krause E, Yuan Y, Hajirahimkhan A, Dong H, Dietz BM, Nikolic D, Pauli GF, Bolton JL, van Breemen RB. Biological and chemical standardization of a hop (Humulus lupulus) botanical dietary supplement. Biomedical Chromatography : Bmc. 28: 729-34. PMID 24861737 DOI: 10.1002/bmc.3177  1
2014 Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR. SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15. PMID 24598415 DOI: 10.1158/1940-6207.CAPR-13-0296  1
2014 Bolton JL. Quinone methide bioactivation pathway: Contribution to toxicity and/or cytoprotection? Current Organic Chemistry. 18: 61-69.  1
2013 Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN, Nikolić D, Dietz BM, Pauli GF, van Breemen RB, Bolton JL. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. Plos One. 8: e67947. PMID 23874474 DOI: 10.1371/journal.pone.0067947  1
2013 Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, ... ... Bolton JL, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. Plos Genetics. 9: e1003500. PMID 23754948 DOI: 10.1371/journal.pgen.1003500  0.72
2013 Dietz BM, Hagos GK, Eskra JN, Wijewickrama GT, Anderson JR, Nikolic D, Guo J, Wright B, Chen SN, Pauli GF, van Breemen RB, Bolton JL. Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. Molecular Nutrition & Food Research. 57: 1055-66. PMID 23512484 DOI: 10.1002/mnfr.201200534  1
2013 Simmler C, Hajirahimkhan A, Lankin DC, Bolton JL, Jones T, Soejarto DD, Chen SN, Pauli GF. Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. Journal of Agricultural and Food Chemistry. 61: 2146-57. PMID 23427769 DOI: 10.1021/jf304445p  1
2013 Hajirahimkhan A, Dietz BM, Bolton JL. Botanical modulation of menopausal symptoms: mechanisms of action? Planta Medica. 79: 538-53. PMID 23408273 DOI: 10.1055/s-0032-1328187  1
2012 Snelten CS, Dietz B, Bolton JL. Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health. Drug Discovery Today. Disease Mechanisms. 9. PMID 24223609 DOI: 10.1016/j.ddmec.2012.11.001  1
2012 Michalsen BT, Gherezghiher TB, Choi J, Chandrasena RE, Qin Z, Thatcher GR, Bolton JL. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol. Chemical Research in Toxicology. 25: 1472-83. PMID 22642258 DOI: 10.1021/tx300142h  1
2012 Toh MF, Sohn J, Chen SN, Yao P, Bolton JL, Burdette JE. Biological characterization of non-steroidal progestins from botanicals used for women's health. Steroids. 77: 765-73. PMID 22484153 DOI: 10.1016/j.steroids.2012.03.013  1
2012 Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chemico-Biological Interactions. 196: 1-10. PMID 22290292 DOI: 10.1016/j.cbi.2012.01.004  1
2012 Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prevention Research (Philadelphia, Pa.). 5: 73-81. PMID 21997247 DOI: 10.1158/1940-6207.CAPR-11-0348  1
2012 Gödecke T, Yao P, Napolitano JG, Nikolić D, Dietz BM, Bolton JL, van Breemen RB, Farnsworth NR, Chen SN, Lankin DC, Pauli GF. Integrated standardization concept for Angelica botanicals using quantitative NMR. Fitoterapia. 83: 18-32. PMID 21907766 DOI: 10.1016/j.fitote.2011.08.017  1
2012 Yanagida GK, Anulacion BF, Bolton JL, Boyd D, Lomax DP, Paul Olson O, Sol SY, Willis M, Ylitalo GM, Johnson LL. Polycyclic aromatic hydrocarbons and risk to threatened and endangered Chinook salmon in the Lower Columbia River estuary. Archives of Environmental Contamination and Toxicology. 62: 282-95. PMID 21894559 DOI: 10.1007/s00244-011-9704-9  0.32
2011 Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/journal.pone.0027876  1
2011 Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 24: 2153-66. PMID 21910479 DOI: 10.1021/tx200294c  1
2011 Liu Y, Reeves D, Kropachev K, Cai Y, Ding S, Kolbanovskiy M, Kolbanovskiy A, Bolton JL, Broyde S, Van Houten B, Geacintov NE. Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro. Dna Repair. 10: 684-96. PMID 21741328 DOI: 10.1016/j.dnarep.2011.04.020  1
2011 Dietz BM, Bolton JL. Biological reactive intermediates (BRIs) formed from botanical dietary supplements. Chemico-Biological Interactions. 192: 72-80. PMID 20970412 DOI: 10.1016/j.cbi.2010.10.007  1
2011 Bolton JL. Mechanisms of estrogen carcinogenesis: Modulation by botanical natural products Current Cancer Research. 6: 75-93. DOI: 10.1007/978-1-61737-995-6_4  1
2010 Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/tx100129h  1
2010 Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73. PMID 20509668 DOI: 10.1021/tx1001282  1
2010 Barton M, Meyer MR, Bolton JL, Prossnitz ER. Lung cancer and hormone replacement therapy. Lancet (London, England). 375: 117-8; author reply . PMID 20109881 DOI: 10.1016/S0140-6736(10)60041-4  1
2010 van Breemen RB, Liang W, Banuvar S, Shulman LP, Pang Y, Tao Y, Nikolic D, Krock KM, Fabricant DS, Chen SN, Hedayat S, Bolton JL, Pauli GF, Piersen CE, Krause EC, et al. Pharmacokinetics of 23-epi-26-deoxyactein in women after oral administration of a standardized extract of black cohosh. Clinical Pharmacology and Therapeutics. 87: 219-25. PMID 20032972 DOI: 10.1038/clpt.2009.251  1
2010 Sloan CA, Anulacion BF, Bolton JL, Boyd D, Olson OP, Sol SY, Ylitalo GM, Johnson LL. Polybrominated diphenyl ethers in outmigrant juvenile chinook Salmon from the lower Columbia river and Estuary and Puget sound, Washington Archives of Environmental Contamination and Toxicology. 58: 403-414. PMID 19771462 DOI: 10.1007/s00244-009-9391-y  0.32
2010 Bolton JL, Thatcher GRJ. Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy The Chemical Biology of Dna Damage. 185-199. DOI: 10.1002/9783527630110.ch8  1
2009 Peng KW, Wang H, Qin Z, Wijewickrama GT, Lu M, Wang Z, Bolton JL, Thatcher GR. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49. PMID 19839584 DOI: 10.1021/cb9001848  1
2009 Ylitalo GM, Baird RW, Yanagida GK, Webster DL, Chivers SJ, Bolton JL, Schorr GS, McSweeney DJ. High levels of persistent organic pollutants measured in blubber of island-associated false killer whales (Pseudorca crassidens) around the main Hawaiian Islands. Marine Pollution Bulletin. 58: 1932-7. PMID 19782380 DOI: 10.1016/j.marpolbul.2009.08.029  0.32
2009 Geller SE, Shulman LP, van Breemen RB, Banuvar S, Zhou Y, Epstein G, Hedayat S, Nikolic D, Krause EC, Piersen CE, Bolton JL, Pauli GF, Farnsworth NR. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause (New York, N.Y.). 16: 1156-66. PMID 19609225 DOI: 10.1097/gme.0b013e3181ace49b  1
2009 Krahn MM, Bradley Hanson M, Schorr GS, Emmons CK, Burrows DG, Bolton JL, Baird RW, Ylitalo GM. Effects of age, sex and reproductive status on persistent organic pollutant concentrations in "Southern Resident" killer whales Marine Pollution Bulletin. 58: 1522-1529. PMID 19541329 DOI: 10.1016/j.marpolbul.2009.05.014  0.32
2009 Zhang N, Ding S, Kolbanovskiy A, Shastry A, Kuzmin VA, Bolton JL, Patel DJ, Broyde S, Geacintov NE. NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms. Biochemistry. 48: 7098-109. PMID 19527068 DOI: 10.1021/bi9006429  1
2009 Wang Z, Edirisinghe P, Sohn J, Qin Z, Geacintov NE, Thatcher GR, Bolton JL. Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chemical Research in Toxicology. 22: 1129-36. PMID 19368368 DOI: 10.1021/tx900063g  1
2009 Yu B, Qin Z, Wijewickrama GT, Edirisinghe P, Bolton JL, Thatcher GR. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjugate Chemistry. 20: 728-41. PMID 19301905 DOI: 10.1021/bc800435m  1
2009 Incardona JP, Carls MG, Day HL, Sloan CA, Bolton JL, Collier TK, Scholz NL. Cardiac arrhythmia is the primary response of embryonic Pacific herring (Clupea pallasi) exposed to crude oil during weathering. Environmental Science & Technology. 43: 201-7. PMID 19209607 DOI: 10.1021/es802270t  0.32
2009 Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR. Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42. PMID 19158089 DOI: 10.1074/jbc.M807860200  1
2009 Gödecke T, Nikolic D, Lankin DC, Chen SN, Powell SL, Dietz B, Bolton JL, van Breemen RB, Farnsworth NR, Pauli GF. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochemical Analysis : Pca. 20: 120-33. PMID 19140115 DOI: 10.1002/pca.1106  1
2009 Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/dmd.108.023408  1
2009 Bolton JL, Thompson JA. Formation and Reactions of Xenobiotic Quinone Methides in Biology Quinone Methides. 329-356. DOI: 10.1002/9780470452882.ch10  1
2008 Powell SL, Gödecke T, Nikolic D, Chen SN, Ahn S, Dietz B, Farnsworth NR, van Breemen RB, Lankin DC, Pauli GF, Bolton JL. In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. Journal of Agricultural and Food Chemistry. 56: 11718-26. PMID 19049296 DOI: 10.1021/jf803298z  1
2008 Dietz BM, Liu D, Hagos GK, Yao P, Schinkovitz A, Pro SM, Deng S, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1. Chemical Research in Toxicology. 21: 1939-48. PMID 18808158 DOI: 10.1021/tx8001274  1
2008 Ding S, Wang Y, Kolbanovskiy A, Durandin A, Bolton JL, van Breemen RB, Broyde S, Geacintov NE. Determination of absolute configurations of 4-hydroxyequilenin-cytosine and -adenine adducts by optical rotatory dispersion, electronic circular dichroism, density functional theory calculations, and mass spectrometry. Chemical Research in Toxicology. 21: 1739-48. PMID 18680315 DOI: 10.1021/tx800095f  1
2008 Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chemico-Biological Interactions. 176: 30-9. PMID 18619951 DOI: 10.1016/j.cbi.2008.06.005  1
2008 Chandrasena RE, Edirisinghe PD, Bolton JL, Thatcher GR. Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chemical Research in Toxicology. 21: 1324-9. PMID 18588320 DOI: 10.1021/tx8000797  1
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  1
2008 Overk CR, Yao P, Chen S, Deng S, Imai A, Main M, Schinkovitz A, Farnsworth NR, Pauli GF, Bolton JL. High-content screening and mechanism-based evaluation of estrogenic botanical extracts. Combinatorial Chemistry & High Throughput Screening. 11: 283-93. PMID 18473738 DOI: 10.2174/138620708784246022  1
2008 Farnsworth NR, Krause EC, Bolton JL, Pauli GF, van Breemen RB, Graham JG. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. The American Journal of Clinical Nutrition. 87: 504S-8S. PMID 18258647  1
2008 Bolton JL, Thatcher GR. Potential mechanisms of estrogen quinone carcinogenesis. Chemical Research in Toxicology. 21: 93-101. PMID 18052105 DOI: 10.1021/tx700191p  1
2007 Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.MCT-07-0268  1
2007 Michel J, Duarte RE, Bolton JL, Huang Y, Caceres A, Veliz M, Soejarto DD, Mahady GB. Medical potential of plants used by the Q'eqchi Maya of Livingston, Guatemala for the treatment of women's health complaints. Journal of Ethnopharmacology. 114: 92-101. PMID 17826926 DOI: 10.1016/j.jep.2007.07.033  1
2007 Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/cmdc.200700104  1
2007 Liu H, Qin Z, Thatcher GR, Bolton JL. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene. Chemical Research in Toxicology. 20: 1676-84. PMID 17630709 DOI: 10.1021/tx7001367  1
2007 Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/en.2006-1568  1
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/jm070079j  1
2007 Dietz B, Bolton JL. Botanical dietary supplements gone bad. Chemical Research in Toxicology. 20: 586-90. PMID 17362034 DOI: 10.1021/tx7000527  1
2007 Johnson LL, Ylitalo GM, Arkoosh MR, Kagley AN, Stafford C, Bolton JL, Buzitis J, Anulacion BF, Collier TK. Contaminant exposure in outmigrant juvenile salmon from Pacific Northwest estuaries of the United States. Environmental Monitoring and Assessment. 124: 167-94. PMID 16957861 DOI: 10.1007/s10661-006-9216-7  0.32
2006 Dowers TS, Qin ZH, Thatcher GR, Bolton JL. Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chemical Research in Toxicology. 19: 1125-37. PMID 16978016 DOI: 10.1021/tx060126v  1
2006 Liu H, Bolton JL, Thatcher GR. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator. Chemical Research in Toxicology. 19: 779-87. PMID 16780356 DOI: 10.1021/tx050326r  1
2006 Cuendet M, Bolton JL. Response of human mammary epithelial cells to DNA damage induced by 4-hydroxyequilenin: Lack of p53-mediated G1 arrest. Chemico-Biological Interactions. 161: 271-8. PMID 16730688 DOI: 10.1016/j.cbi.2006.04.004  1
2006 Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HH, Farnsworth NR, Pauli GF. Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. Journal of Natural Products. 69: 536-41. PMID 16643021 DOI: 10.1021/np050301s  1
2006 Booth NL, Overk CR, Yao P, Burdette JE, Nikolic D, Chen SN, Bolton JL, van Breemen RB, Pauli GF, Farnsworth NR. The chemical and biologic profile of a red clover (Trifolium pratense L.) phase II clinical extract. Journal of Alternative and Complementary Medicine (New York, N.Y.). 12: 133-9. PMID 16566672 DOI: 10.1089/acm.2006.12.133  1
2006 Gafner S, Dietz BM, McPhail KL, Scott IM, Glinski JA, Russell FE, McCollom MM, Budzinski JW, Foster BC, Bergeron C, Rhyu MR, Bolton JL. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. Journal of Natural Products. 69: 432-5. PMID 16562853 DOI: 10.1021/np058114h  1
2006 Booth NL, Overk CR, Yao P, Totura S, Deng Y, Hedayat AS, Bolton JL, Pauli GF, Farnsworth NR. Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. Journal of Agricultural and Food Chemistry. 54: 1277-82. PMID 16478248 DOI: 10.1021/jf052927u  1
2006 Bolton JL. Chapter 1 Bioactivation of Estrogens to Toxic Quinones Advances in Molecular Toxicology. 1: 1-23. DOI: 10.1016/S1872-0854(06)01001-0  1
2005 Kolbanovskiy A, Kuzmin V, Shastry A, Kolbanovskaya M, Chen D, Chang M, Bolton JL, Geacintov NE. Base selectivity and effects of sequence and DNA secondary structure on the formation of covalent adducts derived from the equine estrogen metabolite 4-hydroxyequilenin. Chemical Research in Toxicology. 18: 1737-47. PMID 16300383 DOI: 10.1021/tx050190x  1
2005 Li Y, Yang X, van Breemen RB, Bolton JL. Characterization of two new variants of human catechol O-methyltransferase in vitro. Cancer Letters. 230: 81-9. PMID 16253764 DOI: 10.1016/j.canlet.2004.12.022  1
2005 Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. Analytical Chemistry. 77: 6407-14. PMID 16194107 DOI: 10.1021/ac050892r  1
2005 Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chemical Research in Toxicology. 18: 1485-96. PMID 16167842 DOI: 10.1021/tx0501738  1
2005 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Chemical Research in Toxicology. 18: 1296-305. PMID 16097803 DOI: 10.1021/tx050058x  1
2005 Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). Journal of Agricultural and Food Chemistry. 53: 6246-53. PMID 16076101 DOI: 10.1021/jf050448p  1
2005 Li Y, Yang X, Chang M, Yager JD, van Breemen RB, Bolton JL. Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase. Chemico-Biological Interactions. 152: 151-63. PMID 15840388 DOI: 10.1016/j.cbi.2005.03.001  1
2005 Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/tx0497752  1
2005 Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/tx049776u  1
2005 Sun Y, Gu C, Liu X, Liang W, Yao P, Bolton JL, van Breemen RB. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. Journal of the American Society For Mass Spectrometry. 16: 271-9. PMID 15694777 DOI: 10.1016/j.jasms.2004.11.002  1
2004 Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HH, Farnsworth NR, Pauli GF. Estrogens and congeners from spent hops (Humulus lupulus). Journal of Natural Products. 67: 2024-32. PMID 15620245 DOI: 10.1021/np049783i  1
2004 Li Y, Yao J, Chang M, Cuendet M, Bolton JL. Altered apoptotic response in MCF 10A cells treated with the equine estrogen metabolite, 4-hydroxyequilenin. Toxicology Letters. 154: 225-33. PMID 15501614 DOI: 10.1016/j.toxlet.2004.08.006  1
2004 Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher GR, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chemical Research in Toxicology. 17: 879-88. PMID 15257612 DOI: 10.1021/tx0342722  1
2004 Piersen CE, Booth NL, Sun Y, Liang W, Burdette JE, van Breemen RB, Geller SE, Gu C, Banuvar S, Shulman LP, Bolton JL, Farnsworth NR. Chemical and biological characterization and clinical evaluation of botanical dietary supplements: a phase I red clover extract as a model. Current Medicinal Chemistry. 11: 1361-74. PMID 15180571  1
2004 Cuendet M, Liu X, Pisha E, Li Y, Yao J, Yu L, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression. Mutation Research. 550: 109-21. PMID 15135645 DOI: 10.1016/j.mrfmmm.2004.02.005  1
2004 Li Y, Yao J, Chang M, Nikolic D, Yu L, Yager JD, Mesecar AD, van Breemen RB, Bolton JL. Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. Chemical Research in Toxicology. 17: 512-20. PMID 15089093 DOI: 10.1021/tx0342464  1
2004 Bolton JL, Yu L, Thatcher GR. Quinoids formed from estrogens and antiestrogens. Methods in Enzymology. 378: 110-23. PMID 15038960 DOI: 10.1016/S0076-6879(04)78006-4  1
2004 Liu J, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 11: 18-23. PMID 14974442 DOI: 10.1078/0944-7113-00331  1
2004 Bolton JL, Stehr CM, Boyd DT, Burrows DG, Tkalin AV, Lishavskaya TS. Organic and trace metal contaminants in sediments and English sole tissues from Vancouver Harbour, Canada Marine Environmental Research. 57: 19-36. PMID 12962644 DOI: 10.1016/S0141-1136(03)00058-8  0.32
2003 Toader V, Xu X, Nicolescu A, Yu L, Bolton JL, Thatcher GR. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species. Chemical Research in Toxicology. 16: 1264-76. PMID 14565768 DOI: 10.1021/tx025641h  1
2003 Burdette JE, Liu J, Chen SN, Fabricant DS, Piersen CE, Barker EL, Pezzuto JM, Mesecar A, Van Breemen RB, Farnsworth NR, Bolton JL. Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor. Journal of Agricultural and Food Chemistry. 51: 5661-70. PMID 12952416 DOI: 10.1021/jf034264r  1
2003 Liu X, Pisha E, Tonetti DA, Yao D, Li Y, Yao J, Burdette JE, Bolton JL. Antiestrogenic and DNA damaging effects induced by tamoxifen and toremifene metabolites. Chemical Research in Toxicology. 16: 832-7. PMID 12870885 DOI: 10.1021/tx030004s  1
2003 Liu X, Zhang F, Liu H, Burdette JE, Li Y, Overk CR, Pisha E, Yao J, van Breemen RB, Swanson SM, Bolton JL. Effect of halogenated substituents on the metabolism and estrogenic effects of the equine estrogen, equilenin. Chemical Research in Toxicology. 16: 741-9. PMID 12807357 DOI: 10.1021/tx030001f  1
2003 Johnson BM, Qiu SX, Zhang S, Zhang F, Burdette JE, Yu L, Bolton JL, van Breemen RB. Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). Chemical Research in Toxicology. 16: 733-40. PMID 12807356 DOI: 10.1021/tx020113r  1
2003 Yao J, Li Y, Chang M, Wu H, Yang X, Goodman JE, Liu X, Liu H, Mesecar AD, Van Breemen RB, Yager JD, Bolton JL. Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. Chemical Research in Toxicology. 16: 668-75. PMID 12755597 DOI: 10.1021/tx0340549  1
2002 Xu H, Fabricant DS, Piersen CE, Bolton JL, Pezzuto JM, Fong H, Totura S, Farnsworth NR, Constantinou AI. A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health Phytomedicine. 9: 757-762. PMID 12587700 DOI: 10.1078/094471102321621403  1
2002 Burdette JE, Chen SN, Lu ZZ, Xu H, White BE, Fabricant DS, Liu J, Fong HH, Farnsworth NR, Constantinou AI, Van Breemen RB, Pezzuto JM, Bolton JL. Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles. Journal of Agricultural and Food Chemistry. 50: 7022-8. PMID 12428954 DOI: 10.1021/jf020725h  1
2002 Bolton JL. Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens. Toxicology. 177: 55-65. PMID 12126795 DOI: 10.1016/S0300-483X(02)00195-6  1
2002 Yao J, Chang M, Li Y, Pisha E, Liu X, Yao D, Elguindi EC, Blond SY, Bolton JL. Inhibition of cellular enzymes by equine catechol estrogens in human breast cancer cells: specificity for glutathione S-transferase P1-1. Chemical Research in Toxicology. 15: 935-42. PMID 12119004 DOI: 10.1021/tx020018i  1
2002 Tilbury KL, Stein JE, Krone CA, Brownell RL, Blokhin SA, Bolton JL, Ernest DW. Chemical contaminants in juvenile gray whales (Eschrichtius robustus) from a subsistence harvest in Arctic feeding grounds. Chemosphere. 47: 555-64. PMID 12047066 DOI: 10.1016/S0045-6535(02)00061-9  0.32
2002 Liu X, Yao J, Pisha E, Yang Y, Hua Y, van Breemen RB, Bolton JL. Oxidative DNA damage induced by equine estrogen metabolites: role of estrogen receptor alpha. Chemical Research in Toxicology. 15: 512-9. PMID 11952337 DOI: 10.1021/tx0101649  1
2002 Geun Shin Y, Bolton JL, van Breemen RB. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Combinatorial Chemistry & High Throughput Screening. 5: 59-64. PMID 11860340  1
2002 Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP, Hedayat S, Van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. The Journal of Nutrition. 132: 27-30. PMID 11773503  1
2001 Bolton JL, Chang M. Quinoids as reactive intermediates in estrogen carcinogenesis. Advances in Experimental Medicine and Biology. 500: 497-507. PMID 11764987  1
2001 Zhang F, Swanson SM, van Breemen RB, Liu X, Yang Y, Gu C, Bolton JL. Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases. Chemical Research in Toxicology. 14: 1654-9. PMID 11743748 DOI: 10.1021/tx010158c  1
2001 Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL. Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones. Chemical Research in Toxicology. 14: 1643-53. PMID 11743747 DOI: 10.1021/tx010137i  1
2001 Johnson BM, Bolton JL, Van Breemen RB. Screening botanical extracts for quinoid metabolites Chemical Research in Toxicology. 14: 1546-1551. PMID 11712913 DOI: 10.1021/tx010106n  1
2001 Zhang F, Yao D, Hua Y, van Breemen RB, Bolton JL. Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone. Chemical Research in Toxicology. 14: 754-63. PMID 11409947  1
2001 Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. Journal of Agricultural and Food Chemistry. 49: 2472-9. PMID 11368622 DOI: 10.1021/jf0014157  1
2001 Spink DC, Zhang F, Hussain MM, Katz BH, Liu X, Hilker DR, Bolton JL. Metabolism of equilenin in MCF-7 and MDA-MB-231 human breast cancer cells. Chemical Research in Toxicology. 14: 572-81. PMID 11368557 DOI: 10.1021/tx000219r  1
2001 Fan PW, Bolton JL. Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 891-6. PMID 11353759  1
2001 Chang M, Shin YG, van Breemen RB, Blond SY, Bolton JL. Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. Biochemistry. 40: 4811-20. PMID 11294649 DOI: 10.1021/bi002513o  1
2001 Pisha E, Lui X, Constantinou AI, Bolton JL. Evidence that a metabolilte of equine estrogens, 4-hydroxyequilenin, induces cellular transformation in vitro Chemical Research in Toxicology. 14: 82-90. PMID 11170511 DOI: 10.1021/tx000168y  1
2001 Hua Y, Wainhaus SB, Yang Y, Shen L, Xiong Y, Xu X, Zhang F, Bolton JL, van Breemen RB. Comparison of negative and positive ion electrospray tandem mass spectrometry for the liquid chromatography tandem mass spectrometry analysis of oxidized deoxynucleosides. Journal of the American Society For Mass Spectrometry. 12: 80-7. PMID 11142363 DOI: 10.1016/S1044-0305(00)00191-4  1
2000 Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. European Journal of Cancer (Oxford, England : 1990). 36: 2146-56. PMID 11044654 DOI: 10.1016/S0959-8049(00)00300-2  1
2000 Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines. Chemical Research in Toxicology. 13: 342-50. PMID 10813650 DOI: 10.1021/tx990186j  1
2000 Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ. Role of quinones in toxicology Chemical Research in Toxicology. 13: 135-160. PMID 10725110 DOI: 10.1021/tx9902082  1
2000 Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone. Chemical Research in Toxicology. 13: 53-62. PMID 10649967 DOI: 10.1021/tx990145n  1
2000 Fan PW, Zhang F, Bolton JL. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides. Chemical Research in Toxicology. 13: 45-52. PMID 10649966 DOI: 10.1021/tx990144v  1
1999 Chang M, Bolton JL, Blond SY. Expression and purification of hexahistidine-tagged human glutathione S-transferase P1-1 in Escherichia coli. Protein Expression and Purification. 17: 443-8. PMID 10600464 DOI: 10.1006/prep.1999.1149  1
1999 Nikolic D, Fan PW, Bolton JL, van Breemen RB. Screening for xenobiotic electrophilic metabolites using pulsed ultrafiltration-mass spectrometry. Combinatorial Chemistry & High Throughput Screening. 2: 165-75. PMID 10420970  1
1999 Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 12: 204-13. PMID 10027800 DOI: 10.1021/tx980217v  1
1999 Zhang F, Bolton JL. Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin. Chemical Research in Toxicology. 12: 200-3. PMID 10027799 DOI: 10.1021/tx980189g  1
1998 Bolton JL, Pisha E, Zhang F, Qiu S. Role of quinoids in estrogen carcinogenesis. Chemical Research in Toxicology. 11: 1113-27. PMID 9778307 DOI: 10.1021/tx9801007  1
1998 Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chemical Research in Toxicology. 11: 1105-11. PMID 9760286 DOI: 10.1021/tx980083l  1
1998 Chang M, Zhang F, Shen L, Pauss N, Alam I, van Breemen RB, Blond SY, Bolton JL. Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens. Chemical Research in Toxicology. 11: 758-65. PMID 9671538 DOI: 10.1021/tx9702190  1
1998 Sugumaran M, Bolton JL. Laccase-and not tyrosinase-is the enzyme responsible for quinone methide production from 2,6-dimethoxy-4-allyl phenol Archives of Biochemistry and Biophysics. 353: 207-212. PMID 9606954 DOI: 10.1006/abbi.1998.0653  1
1998 Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikolic D, Bolton JL. Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical. Chemical Research in Toxicology. 11: 94-101. PMID 9511900 DOI: 10.1021/tx970181r  1
1998 Van Breemen RB, Nikolic D, Bolton JL. Metabolic screening using on-line ultrafiltration mass spectrometry Drug Metabolism and Disposition. 26: 85-90. PMID 9456292  1
1998 Sanchez C, Shibutani S, Dasaradhi L, Bolton JL, Fan PW, McClelland RA. Lifetime and reactivity of an ultimate tamoxifen carcinogen: The tamoxifen carbocation [1] Journal of the American Chemical Society. 120: 13513-13514. DOI: 10.1021/ja982701q  1
1997 Bolton JL, Turnipseed SB, Thompson JA. Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: Studies utilizing amino acid and peptide models Chemico-Biological Interactions. 107: 185-200. PMID 9448752 DOI: 10.1016/S0009-2797(97)00079-3  1
1997 Meador JP, Adams NG, Casillas E, Bolton JL. Comparative bioaccumulation of chlorinated hydrocarbons from sediment by two infaunal invertebrates Archives of Environmental Contamination and Toxicology. 33: 388-400. PMID 9419257 DOI: 10.1007/s002449900268  0.32
1997 Bolton JL, Pisha E, Shen L, Krol ES, Iverson SL, Huang Z, Van Breemen RB, Pezzuto JM. The reactivity of o-quinones which do not isomerize to quinone methides correlates with alkylcatechol-induced toxicity in human melanoma cells Chemico-Biological Interactions. 106: 133-148. PMID 9366899 DOI: 10.1016/S0009-2797(97)00066-5  1
1997 Ramakrishna KV, Fan PW, Boyer CS, Dalvie D, Bolton JL. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen. Chemical Research in Toxicology. 10: 887-94. PMID 9282838 DOI: 10.1021/tx970060r  1
1997 Shen L, Pisha E, Huang Z, Pezzuto JM, Krol E, Alam Z, Van Breemen RB, Bolton JL. Bioreductive activation of catechol estrogen-ortho-quinones: Aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity Carcinogenesis. 18: 1093-1101. PMID 9163701 DOI: 10.1093/carcin/18.5.1093  1
1997 Krol ES, Bolton JL. Oxidation of 4-alkylphenols and catechols by tyrosinase: Ortho-substituents alter the mechanism of quinoid formation Chemico-Biological Interactions. 104: 11-27. PMID 9158692 DOI: 10.1016/S0009-2797(97)03763-0  1
1997 Shen L, Qiu S, Van Breemen RB, Zhang F, Chen Y, Bolton JL. Reaction of the premarin metabolite 4-hydroxyequilenin semiquinone radical with 2'-deoxyguanosine: Formation of unusual cyclic adducts Journal of the American Chemical Society. 119: 11126-11127. DOI: 10.1021/ja971396q  1
1997 McCracken PG, Bolton JL, Thatcher GRJ. Covalent Modification of Proteins and Peptides by the Quinone Methide from 2-tert-Butyl-4,6-dimethylphenol: Selectivity and Reactivity with Respect to Competitive Hydration Journal of Organic Chemistry. 62: 1820-1825.  1
1996 Lewis MA, Yoerg DG, Bolton JL, Thompson JA. Alkylation of 2'-deoxynucleosides and DNA by quinone methides derived from 2,6-Di-tert-butyl-4-methylphenol Chemical Research in Toxicology. 9: 1368-1374. PMID 8951242 DOI: 10.1021/tx960115+  1
1996 Bolton JL, Wu HM, Hu LQ. Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide Chemical Research in Toxicology. 9: 109-113. PMID 8924578  1
1996 Iverson SL, Shen L, Anlar N, Bolton JL. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes Chemical Research in Toxicology. 9: 492-499. PMID 8839054  1
1996 Dowsley TF, Ulreich JB, Bolton JL, Park SS, Forkert PG. CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: Formation of reactive intermediates and glutathione conjugates Toxicology and Applied Pharmacology. 139: 42-48. PMID 8685907 DOI: 10.1006/taap.1996.0141  1
1996 Bolton JL, Shen L. p-quinone methides are the major decomposition products of catechol estrogen o-quinones Carcinogenesis. 17: 925-929. PMID 8640939  1
1995 Bolton JL, Comeau E, Vukomanovic V. The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended π-conjugation dramatically stabilizes the quinone methide formed from eugenol Chemico-Biological Interactions. 95: 279-290. PMID 7728898 DOI: 10.1016/0009-2797(94)03566-Q  1
1995 Dowsley TF, Forkert PG, Benesch LA, Bolton JL. Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene Chemico-Biological Interactions. 95: 227-244. PMID 7728894 DOI: 10.1016/0009-2797(94)03563-N  1
1995 Thompson DC, Perera K, Krol ES, Bolton JL. O-methoxy-4-alkylphenols that form quinone methides of intermediate reactivity are the most toxic in rat liver slices Chemical Research in Toxicology. 8: 323-327. PMID 7578916  1
1995 Iverson SL, Hu LQ, Vukomanovic V, Bolton JL. The influence of the p-alkyl substituent on the isomerization of o-quinones to p-quinone methides: Potential bioactivation mechanism for catechols Chemical Research in Toxicology. 8: 537-544. PMID 7548733  1
1994 Bolton JL, Acay NM, Vukomanovic V. Evidence that 4-allyl-o-quinones spontaneously rearrange to their more electrophilic quinone methides: Potential bioactivation mechanism for the hepatocarcinogen safrole Chemical Research in Toxicology. 7: 443-450. PMID 8075378  1
1993 Bolton JL, Thompson JA, Allentoff AJ, Miley FB, Malkinson AM. Metabolic Activation of Butylated Hydroxytoluene by Mouse Bronchiolar Clara Cells Toxicology and Applied Pharmacology. 123: 43-49. PMID 8236260 DOI: 10.1006/taap.1993.1219  1
1993 Krahn MM, Ylitalo GM, Buzitis J, Bolton JL, Wigren CA, Chan SL, Varanasi U. Analyses for petroleum-related contaminants in marine fish and sediments following the Gulf oil spill Marine Pollution Bulletin. 27: 285-292. DOI: 10.1016/0025-326X(93)90035-I  0.32
1993 Bolton JL, Le Blanc JCY. Reaction of quinone methides with proteins: Analysis of myoglobin adduct formation by electrospray mass spectrometry Biological Mass Spectrometry. 22: 666-668. DOI: 10.1002/bms.1200221108  1
1992 Bolton JL, Valerio LG, Thompson JA. The enzymatic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes Chemical Research in Toxicology. 5: 816-822. PMID 1489934  1
1992 Allentoff AJ, Bolton JL, Wilks A, Thompson JA, Ortiz De Montellano PR. Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants Journal of the American Chemical Society. 114: 9744-9749.  1
1991 Thompson JA, Bolton JL, Schullek KM, Sevestre H. Bioactivation of 2,6-di-tert-butyl-4-methyl phenol (BHT) and hydroxylated analogues to toxic quinoid metabolites Advances in Experimental Medicine and Biology. 283: 393-398. PMID 2069012  1
1991 Thompson JA, Bolton JL, Malkinson AM. Relationship between the metabolism of butylated hydroxytoluene (BHT) and lung tumor promotion in mice Experimental Lung Research. 17: 439-453. PMID 2050043 DOI: 10.3109/01902149109064431  1
1991 Bolton JL, Thompson JA. Oxidation of butylated hydroxytoluene to toxic metabolites: Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes Drug Metabolism and Disposition. 19: 467-472. PMID 1676656  1
1990 Bolton JL, Sevestre H, Ibe BO, Thompson JA. Formation and reactivity of alternative quinone methides from butylated hydroxytoluene: possible explanation for species-specific pneumotoxicity. Chemical Research in Toxicology. 3: 65-70. PMID 2131827  1
1990 Thompson JA, Bolton JL, Schullek KM, Ross D. Cytotoxicity of reactive metabolites resulting from the pheraoxy radicals of 2,6-di-tert-butyl-4-methylphenol (BHT) and related alkylphenols European Journal of Pharmacology. 183: 1511-1512.  1
1989 Bolton JL, McClelland RA. Kinetics and mechanism of the decomposition in aqueous solutions of 2-(hydroxyamino)imidazoles Journal of the American Chemical Society. 111: 8172-8181.  1
1988 Bolton JL, McClelland RA. Theoretical studies of imidazole nitrenium and carbenium ions Journal of Molecular Structure: Theochem. 165: 379-389. DOI: 10.1016/0166-1280(88)87034-9  1
1988 Bolton JL, Peterson MR, McClelland RA. Experimental and theoretical investigation of C-nitroso rotation in 2-nitrosoimidazoles Canadian Journal of Chemistry. 66: 3044-3049.  1
1986 Bunting JW, Bolton JL. Relative reactivities of heteroaromatic cations towards reduction by 1,4-dihydronicotinamides Tetrahedron. 42: 1007-1019. DOI: 10.1016/S0040-4020(01)87506-2  1
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