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Nichole E. LaPointe, Ph.D. - Publications

Affiliations: 
2008 Neuroscience Institute Graduate Program Northwestern University, Evanston, IL 
Area:
Neuroscience Biology, Cell Biology, Molecular Biology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Best RL, LaPointe NE, Azarenko O, Miller H, Genualdi C, Chih S, Shen BQ, Jordan MA, Wilson L, Feinstein SC, Stagg NJ. Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy. Toxicology and Applied Pharmacology. 115534. PMID 33852878 DOI: 10.1016/j.taap.2021.115534  0.303
2019 Best RL, LaPointe NE, Liang J, Ruan K, Shade MF, Wilson L, Feinstein SC. Tau isoform-specific stabilization of intermediate states during microtubule assembly and disassembly. The Journal of Biological Chemistry. PMID 31266806 DOI: 10.1074/Jbc.Ra119.009124  0.624
2017 de Almeida NEC, Do TD, LaPointe NE, Tro M, Feinstein SC, Shea JE, Bowers MT. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation. International Journal of Mass Spectrometry. 420: 24-34. PMID 29056865 DOI: 10.1016/J.Ijms.2016.09.018  0.52
2017 Best RL, Chung PJ, Benbow SJ, Savage A, LaPointe NE, Safinya CR, Feinstein SC. Expression and isolation of recombinant tau. Methods in Cell Biology. 141: 3-26. PMID 28882309 DOI: 10.1016/Bs.Mcb.2017.06.001  0.506
2017 Cook B, Proctor D, Bromberg R, LaPointe NE, Feinstein SC, Wilson L. Digital quantification of neurite outgrowth and retraction by phase-contrast microscopy: A tau perspective. Methods in Cell Biology. 141: 217-228. PMID 28882303 DOI: 10.1016/Bs.Mcb.2017.06.003  0.454
2017 Smiyun G, Azarenko O, Miller H, Rifkind A, LaPointe NE, Wilson L, Jordan MA. βIII-tubulin enhances efficacy of cabazitaxel as compared with docetaxel. Cancer Chemotherapy and Pharmacology. PMID 28567478 DOI: 10.1007/S00280-017-3345-2  0.384
2016 Feinstein HE, Benbow SJ, LaPointe NE, Patel N, Ramachandran S, Do TD, Gaylord MR, Huskey NE, Dressler N, Korff M, Quon B, Cantrell KL, Bowers MT, Lal R, Feinstein SC. Oligomerization of the Microtubule Associated Protein Tau is Mediated by its N-Terminal Sequences: Implications for Normal and Pathological Tau Action. Journal of Neurochemistry. PMID 26953146 DOI: 10.1111/Jnc.13604  0.645
2015 Do TD, LaPointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan S, Feinstein SC, Teplow DB, Eisenberg D, Shea JE, Bowers MT. Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels. Journal of the American Chemical Society. PMID 26700445 DOI: 10.1021/Jacs.5B09536  0.439
2015 Do TD, de Almeida NE, Lapointe NE, Chamas A, Feinstein SC, Bowers MT. Amino Acid Metaclusters: Implications of Growth Trends on Peptide Self-Assembly and Structure. Analytical Chemistry. PMID 26632663 DOI: 10.1021/Acs.Analchem.5B03454  0.336
2015 de Almeida NE, Do TD, Tro M, LaPointe NE, Feinstein SC, Shea JE, Bowers MT. Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose on Amyloid β25-35 Assembly. Acs Chemical Neuroscience. PMID 26629788 DOI: 10.1021/Acschemneuro.5B00280  0.494
2015 Eschmann NA, Do TD, LaPointe NE, Shea JE, Feinstein SC, Bowers MT, Han S. Tau Aggregation Propensity Engrained in Its Solution State. The Journal of Physical Chemistry. B. PMID 26484390 DOI: 10.1021/Acs.Jpcb.5B08092  0.453
2015 Ganguly P, Do TD, Larini L, LaPointe NE, Sercel AJ, Shade MF, Feinstein SC, Bowers MT, Shea JE. Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3. The Journal of Physical Chemistry. B. 119: 4582-93. PMID 25775228 DOI: 10.1021/Acs.Jpcb.5B00175  0.436
2015 Levine ZA, Larini L, LaPointe NE, Feinstein SC, Shea JE. Regulation and aggregation of intrinsically disordered peptides. Proceedings of the National Academy of Sciences of the United States of America. 112: 2758-63. PMID 25691742 DOI: 10.1073/Pnas.1418155112  0.562
2014 Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT. Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. The Journal of Physical Chemistry. B. 118: 7247-56. PMID 24915112 DOI: 10.1021/Jp502473S  0.409
2014 Yu D, LaPointe NE, Guzman E, Pessino V, Wilson L, Feinstein SC, Valentine MT. Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro. Journal of Alzheimer's Disease : Jad. 39: 301-14. PMID 24150109 DOI: 10.3233/Jad-131274  0.618
2013 Iyer A, Lapointe NE, Zielke K, Berdynski M, Guzman E, Barczak A, Chodakowska-Å»ebrowska M, Barcikowska M, Feinstein S, Zekanowski C. A novel MAPT mutation, G55R, in a frontotemporal dementia patient leads to altered Tau function. Plos One. 8: e76409. PMID 24086739 DOI: 10.1371/Journal.Pone.0076409  0.567
2013 Do TD, LaPointe NE, Economou NJ, Buratto SK, Feinstein SC, Shea JE, Bowers MT. Effects of pH and charge state on peptide assembly: the YVIFL model system. The Journal of Physical Chemistry. B. 117: 10759-68. PMID 23937333 DOI: 10.1021/Jp406066D  0.394
2013 Do TD, Economou NJ, LaPointe NE, Kincannon WM, Bleiholder C, Feinstein SC, Teplow DB, Buratto SK, Bowers MT. Factors that drive peptide assembly and fibril formation: experimental and theoretical analysis of Sup35 NNQQNY mutants. The Journal of Physical Chemistry. B. 117: 8436-46. PMID 23802812 DOI: 10.1021/Jp4046287  0.386
2013 LaPointe NE, Morfini G, Brady ST, Feinstein SC, Wilson L, Jordan MA. Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. Neurotoxicology. 37: 231-9. PMID 23711742 DOI: 10.1016/J.Neuro.2013.05.008  0.428
2013 Larini L, Gessel MM, LaPointe NE, Do TD, Bowers MT, Feinstein SC, Shea JE. Initiation of assembly of tau(273-284) and its ΔK280 mutant: an experimental and computational study. Physical Chemistry Chemical Physics : Pccp. 15: 8916-28. PMID 23515417 DOI: 10.1039/C3Cp00063J  0.539
2012 Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/J.Neurobiolaging.2011.06.006  0.786
2011 Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/Jneurosci.0560-11.2011  0.769
2011 Peck A, Sargin ME, LaPointe NE, Rose K, Manjunath BS, Feinstein SC, Wilson L. Tau isoform-specific modulation of kinesin-driven microtubule gliding rates and trajectories as determined with tau-stabilized microtubules. Cytoskeleton (Hoboken, N.J.). 68: 44-55. PMID 21162159 DOI: 10.1002/Cm.20494  0.568
2011 Smith JA, LaPointe N, Morfini G, Brady S, Feinstein S, Wilson L, Jordan MA. Abstract C213: Eribulin, vincristine, ixabepilone, and paclitaxel inhibit neuronal cell function by varied mechanisms and to varying degrees. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C213  0.379
2010 Yenjerla M, LaPointe NE, Lopus M, Cox C, Jordan MA, Feinstein SC, Wilson L. The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules. Journal of Alzheimer's Disease : Jad. 19: 1377-86. PMID 20061604 DOI: 10.3233/Jad-2010-1335  0.506
2010 Choi M, Raviv U, Miller H, Gaylord M, Kiris E, Ventimiglia D, Needleman D, Chung P, Deek J, LaPointe N, Kim M, Wilson L, Feinstein S, Safinya C. The Effect of Human Microtubule-Associated-Protein Tau and Ionic Strength on the Assembly Structure of Microtubules: Synchrotron X-Ray Scattering and Binding Assay Study Biophysical Journal. 98: 363a. DOI: 10.1016/J.Bpj.2009.12.1957  0.525
2009 Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI. Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry. 48: 12290-7. PMID 19919107 DOI: 10.1021/Bi901304U  0.763
2009 Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/Jneurosci.3463-09.2009  0.689
2009 Peterson DW, George RC, Scaramozzino F, LaPointe NE, Anderson RA, Graves DJ, Lew J. Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. Journal of Alzheimer's Disease : Jad. 17: 585-97. PMID 19433898 DOI: 10.3233/Jad-2009-1083  0.549
2009 LaPointe NE, Morfini G, Pigino G, Gaisina IN, Kozikowski AP, Binder LI, Brady ST. The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. Journal of Neuroscience Research. 87: 440-51. PMID 18798283 DOI: 10.1002/Jnr.21850  0.777
2006 Horowitz PM, LaPointe N, Guillozet-Bongaarts AL, Berry RW, Binder LI. N-terminal fragments of tau inhibit full-length tau polymerization in vitro. Biochemistry. 45: 12859-66. PMID 17042504 DOI: 10.1021/Bi061325G  0.779
2003 Gamblin TC, Chen F, Zambrano A, Abraha A, Lagalwar S, Guillozet AL, Lu M, Fu Y, Garcia-Sierra F, LaPointe N, Miller R, Berry RW, Binder LI, Cryns VL. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 10032-7. PMID 12888622 DOI: 10.1073/Pnas.1630428100  0.773
2003 Hogg M, Grujic ZM, Baker M, Demirci S, Guillozet AL, Sweet AP, Herzog LL, Weintraub S, Mesulam MM, LaPointe NE, Gamblin TC, Berry RW, Binder LI, de Silva R, Lees A, et al. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. Acta Neuropathologica. 106: 323-36. PMID 12883828 DOI: 10.1007/S00401-003-0734-X  0.664
2003 Berry RW, Abraha A, Lagalwar S, LaPointe N, Gamblin TC, Cryns VL, Binder LI. Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment. Biochemistry. 42: 8325-31. PMID 12846581 DOI: 10.1021/Bi027348M  0.773
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