Alexander R. Horswill, Ph.D. - Publications

Affiliations: 
2001 University of Wisconsin, Madison, Madison, WI 
 2005-2017 Microbiology University of Iowa, Iowa City, IA 
 2017- Immunology & Microbiology University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Microbiology Biology
Website:
http://www.ucdenver.edu/academics/colleges/medicalschool/departments/ImmunologyMicrobiology/faculty/departmental/Pages/HORSWILL.aspx

176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kaplan JB, Horswill AR. Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant USA300. Msphere. 9: e0012624. PMID 38695568 DOI: 10.1128/msphere.00126-24  0.309
2024 Costa FG, Mills KB, Crosby HA, Horswill AR. The regulatory program in a human skin-like environment. Mbio. e0045324. PMID 38546267 DOI: 10.1128/mbio.00453-24  0.793
2024 Crosby HA, Keim K, Kwiecinski JM, Langouët-Astrié CJ, Oshima K, LaRivière WB, Schmidt EP, Horswill AR. Host-derived protease promotes aggregation of by cleaving the surface protein SasG. Mbio. 15: e0348323. PMID 38511930 DOI: 10.1128/mbio.03483-23  0.683
2024 Bhattacharya M, Horswill AR. The role of human extracellular matrix proteins in defining Staphylococcus aureus biofilm infections. Fems Microbiology Reviews. PMID 38337187 DOI: 10.1093/femsre/fuae002  0.357
2024 Schilcher K, Severn MM, Jenul C, Avina YC, Keogh RA, Horswill AR. The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction. Plos Biology. 22: e3002451. PMID 38180978 DOI: 10.1371/journal.pbio.3002451  0.328
2023 Zehr EP, Erzen CL, Oshima K, Langouët-Astrié CJ, LaRiviere WB, Shi D, Zhang F, McCollister BD, Windham SL, Rizzo AN, Bastarache JA, Horswill AR, Schmidt EP, Kwiecinski JM, Colbert JF. Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 38113313 DOI: 10.1152/ajplung.00178.2023  0.317
2023 Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, ... ... Horswill AR, et al. S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Cell. 186: 5375-5393.e25. PMID 37995657 DOI: 10.1016/j.cell.2023.10.019  0.779
2023 Costa FG, Mills KB, Crosby HA, Horswill AR. The regulatory program in a human skin-like environment. Biorxiv : the Preprint Server For Biology. PMID 37961268 DOI: 10.1101/2023.10.24.563767  0.792
2023 Wilkening RV, Langouët-Astrié C, Severn MM, Federle MJ, Horswill AR. Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model. Cell Reports. 42: 113332. PMID 37889753 DOI: 10.1016/j.celrep.2023.113332  0.304
2023 Williams MR, Bagood MD, Enroth TJ, Bunch ZL, Jiang N, Liu E, Almoughrabie S, Khalil S, Li F, Brinton S, Cech NB, Horswill AR, Gallo RL. Staphylococcus epidermidis activates keratinocyte cytokine expression and promotes skin inflammation through the production of phenol-soluble modulins. Cell Reports. 42: 113024. PMID 37610872 DOI: 10.1016/j.celrep.2023.113024  0.306
2023 Cao AL, Mills KB, Nguyen A, Costa FG, Wall E, Horswill AR. Complete Genome Sequence of a Staphylococcus epidermidis Isolate from Healthy Skin with Upregulation of Protease EcpA. Microbiology Resource Announcements. 12: e0046323. PMID 37318351 DOI: 10.1128/mra.00463-23  0.771
2023 Jenul C, Keim KC, Jens JN, Zeiler MJ, Schilcher K, Schurr MJ, Melander C, Phelan VV, Horswill AR. Pyochelin biotransformation by Staphylococcusaureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections. Cell Reports. 42: 112540. PMID 37227819 DOI: 10.1016/j.celrep.2023.112540  0.325
2022 Lyon LM, Doran KS, Horswill AR. Fibronectin-Binding Proteins Contribute to Colonization of the Female Reproductive Tract. Infection and Immunity. e0046022. PMID 36511703 DOI: 10.1128/iai.00460-22  0.309
2022 Mills KB, Roy P, Kwiecinski JM, Fey PD, Horswill AR. Staphylococcal Corneocyte Adhesion: Assay Optimization and Roles of Aap and SasG Adhesins in the Establishment of Healthy Skin Colonization. Microbiology Spectrum. e0246922. PMID 36219106 DOI: 10.1128/spectrum.02469-22  0.327
2022 Lee J, Carda-Diéguez M, Žiemytė M, Vreugde S, Cooksley C, Crosby HA, Horswill AR, Mira A, Zilm PS, Kidd SP. Functional Influences Genetic Changes within a Staphylococcus aureus Cell Population over Time. Journal of Bacteriology. e0013822. PMID 36154359 DOI: 10.1128/jb.00138-22  0.701
2022 Severn MM, Horswill AR. Staphylococcus epidermidis and its dual lifestyle in skin health and infection. Nature Reviews. Microbiology. PMID 36042296 DOI: 10.1038/s41579-022-00780-3  0.325
2022 Kwiecinski JM, Jelani DA, Fuentes EJ, Horswill AR. Therapeutic Inhibition of Staphylococcus aureus ArlRS Two-Component Regulatory System Blocks Virulence. Antimicrobial Agents and Chemotherapy. 66: e0018722. PMID 35736133 DOI: 10.1128/aac.00187-22  0.315
2022 Costa FG, Horswill AR. Overcoming pH defenses on the skin to establish infections. Plos Pathogens. 18: e1010512. PMID 35617212 DOI: 10.1371/journal.ppat.1010512  0.76
2022 Severn MM, Williams MR, Shahbandi A, Bunch ZL, Lyon LM, Nguyen A, Zaramela LS, Todd DA, Zengler K, Cech NB, Gallo RL, Horswill AR. The Ubiquitous Human Skin Commensal Staphylococcus hominis Protects against Opportunistic Pathogens. Mbio. e0093022. PMID 35608301 DOI: 10.1128/mbio.00930-22  0.339
2021 Kwiecinski JM, Kratofil RM, Parlet CP, Surewaard BGJ, Kubes P, Horswill AR. Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection. Cell Reports. 36: 109462. PMID 34320352 DOI: 10.1016/j.celrep.2021.109462  0.319
2021 Crosby HA, Kwiecinski JM, Horswill AR. In Vitro Assay for Quantifying Clumping of Staphylococcus aureus. Methods in Molecular Biology (Clifton, N.J.). 2341: 31-36. PMID 34264458 DOI: 10.1007/978-1-0716-1550-8_5  0.64
2020 Kavanaugh JS, Leidal KG, Nauseef WM, Horswill AR. Cathepsin G degrades Staphylococcus aureus biofilms. The Journal of Infectious Diseases. PMID 32995850 DOI: 10.1093/infdis/jiaa612  0.306
2020 Schilcher K, Horswill AR. Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies. Microbiology and Molecular Biology Reviews : Mmbr. 84. PMID 32792334 DOI: 10.1128/Mmbr.00026-19  0.398
2020 Gupta TT, Gupta NK, Pestrak MJ, Dusane DH, Harro JM, Horswill AR, Stoodley P. Investigation of Aggregates on Orthopedic Materials under Varying Shear Stress. Applied and Environmental Microbiology. PMID 32709721 DOI: 10.1128/Aem.01234-20  0.345
2020 Häffner N, Bär J, Dengler Haunreiter V, Mairpady Shambat S, Seidl K, Crosby HA, Horswill AR, Zinkernagel AS. Intracellular Environment and System Affect Colony Size Heterogeneity of . Frontiers in Microbiology. 11: 1415. PMID 32695082 DOI: 10.3389/Fmicb.2020.01415  0.703
2020 Jones DD, Caesar LK, Pelzer CV, Crandall WJ, Jenul C, Todd DA, Horswill AR, Cech NB. Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA). Journal of Microbiological Methods. 106000. PMID 32649968 DOI: 10.1016/J.Mimet.2020.106000  0.415
2020 Cau L, Williams MR, Butcher AM, Nakatsuji T, Kavanaugh JS, Cheng JY, Shafiq F, Higbee K, Hata TR, Horswill AR, Gallo RL. Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis. The Journal of Allergy and Clinical Immunology. PMID 32634452 DOI: 10.1016/J.Jaci.2020.06.024  0.355
2020 Tang H, Porras G, Brown MM, Chassagne F, Lyles JT, Bacsa J, Horswill AR, Quave CL. Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis. Scientific Reports. 10: 8046. PMID 32415287 DOI: 10.1038/S41598-020-65080-3  0.351
2020 Pestrak MJ, Gupta TT, Dusane DH, Guzior DV, Staats A, Harro J, Horswill AR, Stoodley P. Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation. Plos One. 15: e0231791. PMID 32302361 DOI: 10.1371/Journal.Pone.0231791  0.412
2020 Schilcher K, Caesar LK, Cech NB, Horswill AR. Processing, Export, and Identification of Novel Linear Peptides from Staphylococcus aureus. Mbio. 11. PMID 32291297 DOI: 10.1128/Mbio.00112-20  0.309
2020 Brown MM, Kwiecinski JM, Mejia Cruz L, Shahbandi A, Todd DA, Cech NB, Horswill AR. Novel peptide from commensal blocks MRSA quorum sensing and protects host skin from damage. Antimicrobial Agents and Chemotherapy. PMID 32253213 DOI: 10.1128/Aac.00172-20  0.431
2020 Kwiecinski JM, Horswill AR. Staphylococcus aureus bloodstream infections: pathogenesis and regulatory mechanisms. Current Opinion in Microbiology. 53: 51-60. PMID 32172183 DOI: 10.1016/J.Mib.2020.02.005  0.396
2020 Williams MR, Cau L, Wang Y, Kaul D, Sanford JA, Zaramela LS, Khalil S, Butcher AM, Zengler K, Horswill AR, Dupont CL, Hovnanian A, Gallo RL. Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. Cell Reports. 30: 2923-2933.e7. PMID 32130897 DOI: 10.1016/J.Celrep.2020.02.021  0.401
2020 DelMain EA, Moormeier DE, Endres JL, Hodges RE, Sadykov MR, Horswill AR, Bayles KW. Stochastic Expression of Sae-Dependent Virulence Genes during Staphylococcus aureus Biofilm Development Is Dependent on SaeS. Mbio. 11. PMID 31937649 DOI: 10.1128/Mbio.03081-19  0.463
2020 Cau L, Williams M, Butcher A, Nakatsuji T, Cheng J, Hata T, Kavanaugh J, Mainzer C, Closs B, Horswill A, Gallo RL. 327 Staphylococcus epidermidis protease EcpA is a deleterious component of the skin microbiome in atopic dermatitis Journal of Investigative Dermatology. 140. DOI: 10.1016/J.Jid.2020.03.334  0.333
2019 Sirobhushanam S, Parsa N, Reed TJ, Berthier CC, Sarkar MK, Hile GA, Tsoi LC, Banfield J, Dobry C, Horswill AR, Gudjonsson JE, Kahlenberg JM. Staphylococcus aureus colonization is increased on lupus skin lesions and is promoted by interferon-mediated barrier disruption. The Journal of Investigative Dermatology. PMID 31877319 DOI: 10.1016/J.Jid.2019.11.016  0.373
2019 Deng L, Schilcher K, Burcham LR, Kwiecinski JM, Johnson PM, Head SR, Heinrichs DE, Horswill AR, Doran KS. Identification of Key Determinants of Staphylococcus aureus Vaginal Colonization. Mbio. 10. PMID 31874913 DOI: 10.1128/Mbio.02321-19  0.429
2019 Miller RJ, Crosby HA, Schilcher K, Wang Y, Ortines RV, Mazhar M, Dikeman DA, Pinsker BL, Brown ID, Joyce DP, Zhang J, Archer NK, Liu H, Alphonse MP, Czupryna J, ... ... Horswill AR, et al. Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections. Scientific Reports. 9: 16663. PMID 31723175 DOI: 10.1038/S41598-019-52982-0  0.712
2019 Horswill AR, Gordon CP. Structure-Activity-Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator. Journal of Medicinal Chemistry. PMID 31658413 DOI: 10.1021/Acs.Jmedchem.9B00798  0.353
2019 Crosby HA, Tiwari N, Kwiecinski JM, Xu Z, Dykstra A, Jenul C, Fuentes EJ, Horswill AR. The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA. Molecular Microbiology. PMID 31618469 DOI: 10.1111/Mmi.14404  0.708
2019 Grundstad ML, Parlet CP, Kwiecinski JM, Kavanaugh JS, Crosby HA, Cho YS, Heilmann K, Diekema DJ, Horswill AR. Quorum Sensing, Virulence, and Antibiotic Resistance of USA100 Methicillin-Resistant Staphylococcus aureus Isolates. Msphere. 4. PMID 31413175 DOI: 10.1128/mSphere.00553-19  0.703
2019 Kavanaugh JS, Flack CE, Lister J, Ricker EB, Ibberson CB, Jenul C, Moormeier DE, Delmain EA, Bayles KW, Horswill AR. Identification of Extracellular DNA-Binding Proteins in the Biofilm Matrix. Mbio. 10. PMID 31239382 DOI: 10.1128/Mbio.01137-19  0.41
2019 Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. Plos Pathogens. 15: e1007800. PMID 31116795 DOI: 10.1371/Journal.Ppat.1007800  0.708
2019 Borbón TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME. Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. Plos Neglected Tropical Diseases. 13: e0007247. PMID 31107882 DOI: 10.1371/Journal.Pntd.0007247  0.348
2019 Williams MR, Costa SK, Zaramela LS, Khalil S, Todd DA, Winter HL, Sanford JA, O'Neill AM, Liggins MC, Nakatsuji T, Cech NB, Cheung AL, Zengler K, Horswill AR, Gallo RL. Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis. Science Translational Medicine. 11. PMID 31043573 DOI: 10.1126/Scitranslmed.Aat8329  0.361
2019 Kwiecinski JM, Jacobsson G, Horswill AR, Josefsson E, Jin T. Biofilm formation by Staphylococcus aureus clinical isolates correlates with the infection type. Infectious Diseases (London, England). 1-6. PMID 30985241 DOI: 10.1080/23744235.2019.1593499  0.397
2019 Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A. Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice. Frontiers in Microbiology. 10: 518. PMID 30972040 DOI: 10.3389/Fmicb.2019.00518  0.634
2019 Parlet CP, Kavanaugh JS, Crosby HA, Raja HA, El-Elimat T, Todd DA, Pearce CJ, Cech NB, Oberlies NH, Horswill AR. Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Reports. 27: 187-198.e6. PMID 30943400 DOI: 10.1016/J.Celrep.2019.03.018  0.72
2019 Parlet CP, Brown MM, Horswill AR. Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease. Trends in Microbiology. PMID 30846311 DOI: 10.1016/J.Tim.2019.01.008  0.424
2019 Chang S, Fowler VG, Sharma-Kuinkel BK, Medie F, Park L, Zheng Y, Otto M, Horswill A. 2594. Biofilm-Dispersed Staphylococcus aureus Exhibits a Distinct agr-Independent Host Interaction Open Forum Infectious Diseases. 6: S901-S902. DOI: 10.1093/Ofid/Ofz360.2272  0.367
2019 Cau L, Williams M, Nakatsuji T, Mainzer C, Closs B, Horswill A, Gallo R. 400 Staphylococccus epidermidis can exacerbate atopic dermatitis through the secretion of the cysteine protease EcpA Journal of Investigative Dermatology. 139: S283. DOI: 10.1016/J.Jid.2019.07.402  0.304
2019 Brown M, Todd D, Cech N, Horswill A. 525 Novel peptide from commensal Staphylococcus simulans blocks MRSA quorum sensing and protects host skin from damage Journal of Investigative Dermatology. 139: S90. DOI: 10.1016/J.Jid.2019.03.601  0.356
2018 Jenul C, Horswill AR. Regulation of Virulence. Microbiology Spectrum. 6. PMID 30953424 DOI: 10.1128/Microbiolspec.Gpp3-0031-2018  0.352
2018 Trivedi U, Madsen JS, Everett J, Fell C, Russel J, Haaber J, Crosby HA, Horswill AR, Burmølle M, Rumbaugh KP, Sørensen SJ. coagulases are exploitable yet stable public goods in clinically relevant conditions. Proceedings of the National Academy of Sciences of the United States of America. PMID 30463950 DOI: 10.1073/Pnas.1804850115  0.677
2018 Loftus RW, Dexter F, Robinson ADM, Horswill AR. Desiccation Tolerance is Associated with Staphylococcus aureus Hyper Transmissibility, Resistance, and Infection Development in the Operating Room. The Journal of Hospital Infection. PMID 29966756 DOI: 10.1016/J.Jhin.2018.06.020  0.375
2018 Urbano R, Karlinsey JE, Libby SJ, Doulias PT, Ischiropoulos H, Warheit-Niemi HI, Liggitt DH, Horswill AR, Fang FC. Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Cell Host & Microbe. PMID 29706505 DOI: 10.1016/J.Chom.2018.04.001  0.34
2018 Chen Y, Crosby HA, Oosthuysen WF, Diekema DJ, Kelley ST, Horswill AR. Draft Genome Sequence of USA100 Methicillin-Resistant Staphylococcus aureus Strain 209. Genome Announcements. 6. PMID 29301880 DOI: 10.1128/Genomea.01399-17  0.685
2018 Quave CL, Horswill AR. Identification of Staphylococcal Quorum Sensing Inhibitors by Quantification of õ-Hemolysin with High Performance Liquid Chromatography. Methods in Molecular Biology (Clifton, N.J.). 1673: 363-370. PMID 29130186 DOI: 10.1007/978-1-4939-7309-5_27  0.32
2018 Williams M, Sanford J, Nakatsuji T, Horswill A, Gallo R. 920 Quorum sensing between bacterial species on skin protects against barrier disruption and inflammation promoted by Staphyloccocus aureus Journal of Investigative Dermatology. 138: S156. DOI: 10.1016/J.Jid.2018.03.932  0.368
2017 Paharik AE, Parlet CP, Chung N, Todd DA, Rodriguez EI, Van Dyke MJ, Cech NB, Horswill AR. Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing. Cell Host & Microbe. 22: 746-756.e5. PMID 29199097 DOI: 10.1016/J.Chom.2017.11.001  0.458
2017 Mishra S, Horswill AR. Heparin Mimics Extracellular DNA in Binding to Cell Surface-Localized Proteins and Promoting Staphylococcus aureus Biofilm Formation. Msphere. 2. PMID 28656173 DOI: 10.1128/mSphere.00135-17  0.336
2017 Todd DA, Parlet CP, Crosby HA, Malone CL, Heilmann KP, Horswill AR, Cech NB. Targeting quorum sensing signal biosynthesis to fight antibiotic resistant infections: Ambuic acid as a model inhibitor. Antimicrobial Agents and Chemotherapy. PMID 28607020 DOI: 10.1128/Aac.00263-17  0.717
2017 Nicholson TL, Brockmeier SL, Sukumar N, Paharik AE, Lister JL, Horswill AR, Kehrli ME, Loving CL, Shore SM, Deora R. The Bordetella Bps Polysaccharide is required for Biofilm Formation and Enhances Survival in the Lower Respiratory Tract of Swine. Infection and Immunity. PMID 28559403 DOI: 10.1128/Iai.00261-17  0.415
2017 Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL. Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Scientific Reports. 7: 42275. PMID 28186134 DOI: 10.1038/Srep42275  0.469
2016 Paharik AE, Kotasinska M, Both A, Hoang TM, Büttner H, Roy P, Fey PD, Horswill AR, Rohde H. The metalloprotease SepA governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in Staphylococcus epidermidis. Molecular Microbiology. PMID 27997732 DOI: 10.1111/Mmi.13594  0.441
2016 Schaeffer CR, Hoang TN, Sudbeck CM, Alawi M, Tolo IE, Robinson DA, Horswill AR, Rohde H, Fey PD. Versatility of Biofilm Matrix Molecules in Staphylococcus epidermidis Clinical Isolates and Importance of Polysaccharide Intercellular Adhesin Expression during High Shear Stress. Msphere. 1. PMID 27747298 DOI: 10.1128/mSphere.00165-16  0.327
2016 Paharik AE, Salgado-Pabon W, Meyerholz DK, White MJ, Schlievert PM, Horswill AR. The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia. Msphere. 1. PMID 27747296 DOI: 10.1128/mSphere.00208-16  0.35
2016 Gordon CP, Olson SD, Lister JL, Kavanaugh JS, Horswill AR. Truncated auto-inducing peptides as antagonists of Staphylococcus lugdunensis quorum sensing. Journal of Medicinal Chemistry. PMID 27585401 DOI: 10.1021/Acs.Jmedchem.6B00727  0.34
2016 Crosby HA, Kwiecinski J, Horswill AR. Staphylococcus aureus Aggregation and Coagulation Mechanisms, and Their Function in Host-Pathogen Interactions. Advances in Applied Microbiology. 96: 1-41. PMID 27565579 DOI: 10.1016/bs.aambs.2016.07.018  0.313
2016 Todd DA, Zich DB, Ettefagh KA, Kavanaugh JS, Horswill AR, Cech NB. Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition. Journal of Microbiological Methods. PMID 27237773 DOI: 10.1016/J.Mimet.2016.05.024  0.404
2016 Paharik AE, Horswill AR. The Staphylococcal Biofilm: Adhesins, Regulation, and Host Response. Microbiology Spectrum. 4. PMID 27227309 DOI: 10.1128/Microbiolspec.Vmbf-0022-2015  0.414
2016 Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. Acs Chemical Biology. PMID 27159024 DOI: 10.1021/Acschembio.6B00120  0.422
2016 Crosby HA, Schlievert PM, Merriman JA, King JM, Salgado-Pabón W, Horswill AR. The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression. Plos Pathogens. 12: e1005604. PMID 27144398 DOI: 10.1371/Journal.Ppat.1005604  0.717
2016 Kavanaugh JS, Horswill AR. Impact of environmental cues on Staphylococcal quorum-sensing and biofilm development. The Journal of Biological Chemistry. PMID 27129223 DOI: 10.1074/Jbc.R116.722710  0.423
2016 Ibberson CB, Parlet CP, Kwiecinski J, Crosby HA, Meyerholz DK, Horswill AR. Hyaluronan modulation impacts Staphylococcus aureus biofilm infection. Infection and Immunity. PMID 27068096 DOI: 10.1128/Iai.01418-15  0.707
2016 Herrera A, Vu BG, Stach CS, Merriman JA, Horswill AR, Salgado-Pabon W, Schlievert PM. Staphylococcus aureus β-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis/Sepsis. Biochemistry. PMID 27015018 DOI: 10.1021/Acs.Biochem.6B00083  0.388
2016 Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, Kaplan JB. Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms. Antimicrobial Agents and Chemotherapy. PMID 26856828 DOI: 10.1128/Aac.02070-15  0.415
2016 Lyles J, Kavanaugh J, Nelson K, Parlet C, Crosby H, Heilmann K, Horswill A, Quave C. Structure Elucidation Of Ursene And Oleanene Derivatives From Castanea Sativa (European Chestnut) That Inhibit Staphylococcus Aureus Virulence And Pathogenesis Planta Medica. 82. DOI: 10.1055/S-0036-1578746  0.684
2015 Kiedrowski MR, Paharik AE, Ackermann LW, Shelton AU, Singh SB, Starner TD, Horswill AR. Development of an in vitro colonization model to investigate Staphylococcus aureus interactions with airway epithelia. Cellular Microbiology. PMID 26566259 DOI: 10.1111/Cmi.12543  0.429
2015 Britton ER, Ibberson CB, Horswill AR, Cech NB. A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition. Journal of Microbiological Methods. 119: 163-167. PMID 26519769 DOI: 10.1016/J.Mimet.2015.10.019  0.366
2015 Scherr TD, Hanke ML, Huang O, James DB, Horswill AR, Bayles KW, Fey PD, Torres VJ, Kielian T. Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin. Mbio. 6. PMID 26307164 DOI: 10.1128/Mbio.01021-15  0.408
2015 Quave CL, Lyles JT, Kavanaugh JS, Nelson K, Parlet CP, Crosby HA, Heilmann KP, Horswill AR. Castanea sativa (European Chestnut) Leaf Extracts Rich in Ursene and Oleanene Derivatives Block Staphylococcus aureus Virulence and Pathogenesis without Detectable Resistance. Plos One. 10: e0136486. PMID 26295163 DOI: 10.1371/Journal.Pone.0136486  0.71
2015 Decker R, Burdelski C, Zobiak M, Büttner H, Franke G, Christner M, Saß K, Zobiak B, Henke HA, Horswill AR, Bischoff M, Bur S, Hartmann T, Schaeffer CR, Fey PD, et al. An 18 kDa scaffold protein is critical for Staphylococcus epidermidis biofilm formation. Plos Pathogens. 11: e1004735. PMID 25799153 DOI: 10.1371/Journal.Ppat.1004735  0.434
2015 Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR. ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation. Antimicrobial Agents and Chemotherapy. 59: 2223-35. PMID 25645827 DOI: 10.1128/Aac.04564-14  0.738
2015 Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR. Rot is a key regulator of Staphylococcus aureus biofilm formation. Molecular Microbiology. 96: 388-404. PMID 25612137 DOI: 10.1111/Mmi.12943  0.739
2015 Parlet CP, Kavanaugh JS, Horswill AR, Schlueter AJ. Chronic ethanol feeding increases the severity of Staphylococcus aureus skin infections by altering local host defenses. Journal of Leukocyte Biology. 97: 769-78. PMID 25605871 DOI: 10.1189/Jlb.4A0214-092R  0.377
2015 Schaeffer CR, Woods KM, Longo GM, Kiedrowski MR, Paharik AE, Büttner H, Christner M, Boissy RJ, Horswill AR, Rohde H, Fey PD. Accumulation-associated protein enhances Staphylococcus epidermidis biofilm formation under dynamic conditions and is required for infection in a rat catheter model. Infection and Immunity. 83: 214-26. PMID 25332125 DOI: 10.1128/Iai.02177-14  0.42
2015 Britton E, Ibberson C, Leyte-Lugo M, Bussey III R, Raja H, Oberlies N, Horswill A, Cech N. A new anti-virulence strategy against pathogenic bacteria: Targeting spreading factors Planta Medica. 81. DOI: 10.1055/S-0035-1556215  0.441
2015 Todd D, Zich D, Horswill A, Cech N. A novel bioassay to identify anti-virulence leads against gram-positive bacterial pathogens Planta Medica. 81. DOI: 10.1055/S-0035-1556180  0.368
2014 Lister JL, Horswill AR. Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Frontiers in Cellular and Infection Microbiology. 4: 178. PMID 25566513 DOI: 10.3389/Fcimb.2014.00178  0.427
2014 Quave CL, Horswill AR. Flipping the switch: tools for detecting small molecule inhibitors of staphylococcal virulence. Frontiers in Microbiology. 5: 706. PMID 25566220 DOI: 10.3389/Fmicb.2014.00706  0.346
2014 Abou Alaiwa MH, Reznikov LR, Gansemer ND, Sheets KA, Horswill AR, Stoltz DA, Zabner J, Welsh MJ. pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37. Proceedings of the National Academy of Sciences of the United States of America. 111: 18703-8. PMID 25512526 DOI: 10.1073/Pnas.1422091112  0.351
2014 Moormeier DE, Bose JL, Horswill AR, Bayles KW. Temporal and stochastic control of Staphylococcus aureus biofilm development. Mbio. 5: e01341-14. PMID 25316695 DOI: 10.1128/Mbio.01341-14  0.42
2014 DeLeon S, Clinton A, Fowler H, Everett J, Horswill AR, Rumbaugh KP. Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model. Infection and Immunity. 82: 4718-28. PMID 25156721 DOI: 10.1128/Iai.02198-14  0.448
2014 Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, Büttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR. Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization. Journal of Bacteriology. 196: 3482-93. PMID 25070736 DOI: 10.1128/Jb.01882-14  0.397
2014 Ibberson CB, Jones CL, Singh S, Wise MC, Hart ME, Zurawski DV, Horswill AR. Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor. Infection and Immunity. 82: 4253-64. PMID 25069977 DOI: 10.1128/Iai.01710-14  0.471
2014 Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Plos Pathogens. 10: e1004174. PMID 24945495 DOI: 10.1371/Journal.Ppat.1004174  0.478
2014 Figueroa M, Jarmusch AK, Raja HA, El-Elimat T, Kavanaugh JS, Horswill AR, Cooks RG, Cech NB, Oberlies NH. Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry. Journal of Natural Products. 77: 1351-8. PMID 24911880 DOI: 10.1021/Np5000704  0.303
2014 Flack CE, Zurek OW, Meishery DD, Pallister KB, Malone CL, Horswill AR, Voyich JM. Differential regulation of staphylococcal virulence by the sensor kinase SaeS in response to neutrophil-derived stimuli. Proceedings of the National Academy of Sciences of the United States of America. 111: E2037-45. PMID 24782537 DOI: 10.1073/Pnas.1322125111  0.388
2014 Kiedrowski MR, Crosby HA, Hernandez FJ, Malone CL, McNamara JO, Horswill AR. Staphylococcus aureus Nuc2 is a functional, surface-attached extracellular nuclease. Plos One. 9: e95574. PMID 24752186 DOI: 10.1371/Journal.Pone.0095574  0.735
2014 Sommerfeld Ross S, Tu MH, Falsetta ML, Ketterer MR, Kiedrowski MR, Horswill AR, Apicella MA, Reinhardt JM, Fiegel J. Quantification of confocal images of biofilms grown on irregular surfaces. Journal of Microbiological Methods. 100: 111-20. PMID 24632515 DOI: 10.1016/J.Mimet.2014.02.020  0.34
2014 Hernandez FJ, Huang L, Olson ME, Powers KM, Hernandez LI, Meyerholz DK, Thedens DR, Behlke MA, Horswill AR, McNamara JO. Noninvasive imaging of Staphylococcus aureus infections with a nuclease-activated probe. Nature Medicine. 20: 301-6. PMID 24487433 DOI: 10.1038/Nm.3460  0.409
2014 White MJ, Boyd JM, Horswill AR, Nauseef WM. Phosphatidylinositol-specific phospholipase C contributes to survival of Staphylococcus aureus USA300 in human blood and neutrophils. Infection and Immunity. 82: 1559-71. PMID 24452683 DOI: 10.1128/Iai.01168-13  0.473
2014 Pang YY, Schwartz J, Bloomberg S, Boyd JM, Horswill AR, Nauseef WM. Methionine sulfoxide reductases protect against oxidative stress in Staphylococcus aureus encountering exogenous oxidants and human neutrophils. Journal of Innate Immunity. 6: 353-64. PMID 24247266 DOI: 10.1159/000355915  0.371
2014 Zurek OW, Nygaard TK, Watkins RL, Pallister KB, Torres VJ, Horswill AR, Voyich JM. The role of innate immunity in promoting SaeR/S-mediated virulence in Staphylococcus aureus. Journal of Innate Immunity. 6: 21-30. PMID 23816635 DOI: 10.1159/000351200  0.418
2013 Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. Plos One. 8: e84089. PMID 24386336 DOI: 10.1371/Journal.Pone.0084089  0.436
2013 Walker JN, Crosby HA, Spaulding AR, Salgado-Pabón W, Malone CL, Rosenthal CB, Schlievert PM, Boyd JM, Horswill AR. The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis. Plos Pathogens. 9: e1003819. PMID 24367264 DOI: 10.1371/Journal.Ppat.1003819  0.778
2013 Cech NB, Horswill AR. Small-molecule quorum quenchers to prevent Staphylococcus aureus infection. Future Microbiology. 8: 1511-4. PMID 24266350 DOI: 10.2217/Fmb.13.134  0.423
2013 Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501: 52-7. PMID 23965627 DOI: 10.1038/Nature12479  0.322
2013 Salgado-Pabón W, Breshears L, Spaulding AR, Merriman JA, Stach CS, Horswill AR, Peterson ML, Schlievert PM. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. Mbio. 4. PMID 23963178 DOI: 10.1128/Mbio.00494-13  0.378
2013 Yu J, Madsen ML, Carruthers MD, Phillips GJ, Kavanaugh JS, Boyd JM, Horswill AR, Minion FC. Analysis of autoinducer-2 quorum sensing in Yersinia pestis. Infection and Immunity. 81: 4053-62. PMID 23959719 DOI: 10.1128/Iai.00880-13  0.387
2013 Spaulding AR, Salgado-Pabón W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. Staphylococcal and streptococcal superantigen exotoxins. Clinical Microbiology Reviews. 26: 422-47. PMID 23824366 DOI: 10.1128/Cmr.00104-12  0.315
2013 Mootz JM, Malone CL, Shaw LN, Horswill AR. Staphopains modulate Staphylococcus aureus biofilm integrity. Infection and Immunity. 81: 3227-38. PMID 23798534 DOI: 10.1128/Iai.00377-13  0.455
2013 Olson ME, Horswill AR. Staphylococcus aureus osteomyelitis: bad to the bone. Cell Host & Microbe. 13: 629-31. PMID 23768487 DOI: 10.1016/J.Chom.2013.05.015  0.322
2013 Junio HA, Todd DA, Ettefagh KA, Ehrmann BM, Kavanaugh JS, Horswill AR, Cech NB. Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 930: 7-12. PMID 23703543 DOI: 10.1016/J.Jchromb.2013.04.019  0.382
2013 LaRock CN, Yu J, Horswill AR, Parsek MR, Minion FC. Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]. Plos One. 8: e62337. PMID 23620823 DOI: 10.1371/Journal.Pone.0062337  0.337
2013 Moormeier DE, Endres JL, Mann EE, Sadykov MR, Horswill AR, Rice KC, Fey PD, Bayles KW. Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches Applied and Environmental Microbiology. 79: 3413-3424. PMID 23524683 DOI: 10.1128/Aem.00395-13  0.394
2013 Hall PR, Elmore BO, Spang CH, Alexander SM, Manifold-Wheeler BC, Castleman MJ, Daly SM, Peterson MM, Sully EK, Femling JK, Otto M, Horswill AR, Timmins GS, Gresham HD. Nox2 modification of LDL is essential for optimal apolipoprotein B-mediated control of agr type III Staphylococcus aureus quorum-sensing. Plos Pathogens. 9: e1003166. PMID 23459693 DOI: 10.1371/Journal.Ppat.1003166  0.378
2013 Olson ME, King JM, Yahr TL, Horswill AR. Sialic acid catabolism in Staphylococcus aureus. Journal of Bacteriology. 195: 1779-88. PMID 23396916 DOI: 10.1128/Jb.02294-12  0.426
2013 Olson ME, Nygaard TK, Ackermann L, Watkins RL, Zurek OW, Pallister KB, Griffith S, Kiedrowski MR, Flack CE, Kavanaugh JS, Kreiswirth BN, Horswill AR, Voyich JM. Staphylococcus aureus nuclease is an SaeRS-dependent virulence factor. Infection and Immunity. 81: 1316-24. PMID 23381999 DOI: 10.1128/Iai.01242-12  0.463
2013 Abdelhady W, Bayer AS, Seidl K, Nast CC, Kiedrowski MR, Horswill AR, Yeaman MR, Xiong YQ. Reduced vancomycin susceptibility in an in vitro catheter-related biofilm model correlates with poor therapeutic outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 57: 1447-54. PMID 23295925 DOI: 10.1128/Aac.02073-12  0.45
2013 Kolar SL, Ibarra JA, Rivera FE, Mootz JM, Davenport JE, Stevens SM, Horswill AR, Shaw LN. Extracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability. Microbiologyopen. 2: 18-34. PMID 23233325 DOI: 10.1002/mbo3.55  0.334
2013 Thoendel M, Horswill AR. Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins in Staphylococcus aureus. Molecular Microbiology. 87: 318-37. PMID 23216863 DOI: 10.1111/Mmi.12100  0.347
2012 Zielinska AK, Beenken KE, Mrak LN, Spencer HJ, Post GR, Skinner RA, Tackett AJ, Horswill AR, Smeltzer MS. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Molecular Microbiology. 86: 1183-96. PMID 23075270 DOI: 10.1111/Mmi.12048  0.425
2012 Walker JN, Horswill AR. A coverslip-based technique for evaluating Staphylococcus aureus biofilm formation on human plasma. Frontiers in Cellular and Infection Microbiology. 2: 39. PMID 22919630 DOI: 10.3389/Fcimb.2012.00039  0.632
2012 Kaplan JB, Izano EA, Gopal P, Karwacki MT, Kim S, Bose JL, Bayles KW, Horswill AR. Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. Mbio. 3: e00198-12. PMID 22851659 DOI: 10.1128/Mbio.00198-12  0.421
2012 Laarman AJ, Mijnheer G, Mootz JM, van Rooijen WJ, Ruyken M, Malone CL, Heezius EC, Ward R, Milligan G, van Strijp JA, de Haas CJ, Horswill AR, van Kessel KP, Rooijakkers SH. Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. The Embo Journal. 31: 3607-19. PMID 22850671 DOI: 10.1038/Emboj.2012.212  0.422
2012 Boles BR, Horswill AR. Swimming cells promote a dynamic environment within biofilms. Proceedings of the National Academy of Sciences of the United States of America. 109: 12848-9. PMID 22847434 DOI: 10.1073/Pnas.1210297109  0.366
2012 Cech NB, Junio HA, Ackermann LW, Kavanaugh JS, Horswill AR. Quorum quenching and antimicrobial activity of goldenseal (Hydrastis canadensis) against methicillin-resistant Staphylococcus aureus (MRSA). Planta Medica. 78: 1556-61. PMID 22814821 DOI: 10.1055/S-0032-1315042  0.358
2012 Pezzulo AA, Tang XX, Hoegger MJ, Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB, Welsh MJ, et al. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature. 487: 109-13. PMID 22763554 DOI: 10.1038/Nature11130  0.329
2012 Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. The Journal of Biological Chemistry. 287: 13889-98. PMID 22371493 DOI: 10.1074/Jbc.M112.349860  0.421
2012 Ettefagh K, Todd D, Junio H, Horswill A, Cech N. Mass spectrometric detection of virulence factors from methecillin-resistant Staphylococcus aureus (MRSA) Planta Medica. 78. DOI: 10.1055/S-0032-1321236  0.338
2011 Kiedrowski MR, Horswill AR. New approaches for treating staphylococcal biofilm infections. Annals of the New York Academy of Sciences. 1241: 104-21. PMID 22191529 DOI: 10.1111/J.1749-6632.2011.06281.X  0.419
2011 Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. Plos One. 6: e26714. PMID 22096493 DOI: 10.1371/Journal.Pone.0026714  0.457
2011 Wörmann ME, Reichmann NT, Malone CL, Horswill AR, Gründling A. Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase. Journal of Bacteriology. 193: 5279-91. PMID 21784926 DOI: 10.1128/Jb.00369-11  0.357
2011 Boles BR, Horswill AR. Staphylococcal biofilm disassembly. Trends in Microbiology. 19: 449-55. PMID 21784640 DOI: 10.1016/J.Tim.2011.06.004  0.424
2011 Lin YC, Anderson MJ, Kohler PL, Strandberg KL, Olson ME, Horswill AR, Schlievert PM, Peterson ML. Proinflammatory exoprotein characterization of toxic shock syndrome Staphylococcus aureus. Biochemistry. 50: 7157-67. PMID 21749039 DOI: 10.1021/Bi200435N  0.433
2011 Benson MA, Lilo S, Wasserman GA, Thoendel M, Smith A, Horswill AR, Fraser J, Novick RP, Shopsin B, Torres VJ. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology. 81: 659-75. PMID 21651625 DOI: 10.1111/J.1365-2958.2011.07720.X  0.438
2011 Thurlow LR, Hanke ML, Fritz T, Angle A, Aldrich A, Williams SH, Engebretsen IL, Bayles KW, Horswill AR, Kielian T. Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 186: 6585-96. PMID 21525381 DOI: 10.4049/Jimmunol.1002794  0.425
2011 Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH. Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion. Journal of Immunology (Baltimore, Md. : 1950). 186: 6445-53. PMID 21502375 DOI: 10.4049/Jimmunol.1002948  0.382
2011 Kirchdoerfer RN, Garner AL, Flack CE, Mee JM, Horswill AR, Janda KD, Kaufmann GF, Wilson IA. Structural basis for ligand recognition and discrimination of a quorum-quenching antibody. The Journal of Biological Chemistry. 286: 17351-8. PMID 21454495 DOI: 10.1074/Jbc.M111.231258  0.387
2011 Thoendel M, Kavanaugh JS, Flack CE, Horswill AR. Peptide signaling in the staphylococci. Chemical Reviews. 111: 117-51. PMID 21174435 DOI: 10.1021/Cr100370N  0.365
2011 Hammond AA, Miller KG, Kruczek CJ, Dertien J, Colmer-Hamood JA, Griswold JA, Horswill AR, Hamood AN. An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates. Burns : Journal of the International Society For Burn Injuries. 37: 312-21. PMID 21130579 DOI: 10.1016/J.Burns.2010.09.017  0.424
2010 Berends ET, Horswill AR, Haste NM, Monestier M, Nizet V, von Köckritz-Blickwede M. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. Journal of Innate Immunity. 2: 576-86. PMID 20829609 DOI: 10.1159/000319909  0.482
2010 Pang YY, Schwartz J, Thoendel M, Ackermann LW, Horswill AR, Nauseef WM. agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. Journal of Innate Immunity. 2: 546-59. PMID 20829608 DOI: 10.1159/000319855  0.396
2010 Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS. Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. Plos One. 5: e10790. PMID 20520723 DOI: 10.1371/Journal.Pone.0010790  0.426
2010 Boles BR, Thoendel M, Roth AJ, Horswill AR. Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. Plos One. 5: e10146. PMID 20418950 DOI: 10.1371/Journal.Pone.0010146  0.453
2010 Thoendel M, Horswill AR. Biosynthesis of peptide signals in gram-positive bacteria. Advances in Applied Microbiology. 71: 91-112. PMID 20378052 DOI: 10.1016/S0065-2164(10)71004-2  0.306
2010 Lauderdale KJ, Malone CL, Boles BR, Morcuende J, Horswill AR. Biofilm dispersal of community-associated methicillin-resistant Staphylococcus aureus on orthopedic implant material. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 55-61. PMID 19610092 DOI: 10.1002/Jor.20943  0.408
2009 Thoendel M, Horswill AR. Identification of Staphylococcus aureus AgrD residues required for autoinducing peptide biosynthesis. The Journal of Biological Chemistry. 284: 21828-38. PMID 19520867 DOI: 10.1074/Jbc.M109.031757  0.376
2009 Mann EE, Rice KC, Boles BR, Endres JL, Ranjit D, Chandramohan L, Tsang LH, Smeltzer MS, Horswill AR, Bayles KW. Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. Plos One. 4: e5822. PMID 19513119 DOI: 10.1371/Journal.Pone.0005822  0.366
2009 Malone CL, Boles BR, Lauderdale KJ, Thoendel M, Kavanaugh JS, Horswill AR. Fluorescent reporters for Staphylococcus aureus. Journal of Microbiological Methods. 77: 251-60. PMID 19264102 DOI: 10.1016/J.Mimet.2009.02.011  0.351
2009 Lauderdale KJ, Boles BR, Cheung AL, Horswill AR. Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation. Infection and Immunity. 77: 1623-35. PMID 19188357 DOI: 10.1128/Iai.01036-08  0.467
2008 Horswill AR, Nauseef WM. Host interception of bacterial communication signals. Cell Host & Microbe. 4: 507-9. PMID 19064249 DOI: 10.1016/J.Chom.2008.11.003  0.358
2008 Boles BR, Horswill AR. Agr-mediated dispersal of Staphylococcus aureus biofilms. Plos Pathogens. 4: e1000052. PMID 18437240 DOI: 10.1371/Journal.Ppat.1000052  0.458
2007 Malone CL, Boles BR, Horswill AR. Biosynthesis of Staphylococcus aureus autoinducing peptides by using the synechocystis DnaB mini-intein. Applied and Environmental Microbiology. 73: 6036-44. PMID 17693565 DOI: 10.1128/Aem.00912-07  0.392
2007 Kavanaugh JS, Thoendel M, Horswill AR. A role for type I signal peptidase in Staphylococcus aureus quorum sensing. Molecular Microbiology. 65: 780-98. PMID 17608791 DOI: 10.1111/J.1365-2958.2007.05830.X  0.421
2007 Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Science : a Publication of the Protein Society. 16: 1535-42. PMID 17600141 DOI: 10.1110/Ps.072933007  0.757
2006 Horswill AR, Benkovic SJ. Identifying small-molecule modulators of protein-protein interactions. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 19.15. PMID 18429304 DOI: 10.1002/0471140864.Ps1915S46  0.465
2005 Horswill AR, Benkovic SJ. Cyclic peptides, a chemical genetics tool for biologists. Cell Cycle (Georgetown, Tex.). 4: 552-5. PMID 15876867 DOI: 10.4161/Cc.4.4.1585  0.451
2004 Horswill AR, Savinov SN, Benkovic SJ. A systematic method for identifying small-molecule modulators of protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 101: 15591-6. PMID 15498867 DOI: 10.1073/Pnas.0406999101  0.464
2004 Horswill AR, Naumann TA, Benkovic SJ. Using incremental truncation to create libraries of hybrid enzymes. Methods in Enzymology. 388: 50-60. PMID 15289061 DOI: 10.1016/S0076-6879(04)88006-6  0.476
2004 Lewis JA, Horswill AR, Schwem BE, Escalante-Semerena JC. The Tricarballylate utilization (tcuRABC) genes of Salmonella enterica serovar Typhimurium LT2. Journal of Bacteriology. 186: 1629-37. PMID 14996793 DOI: 10.1128/Jb.186.6.1629-1637.2004  0.774
2004 Saraf MC, Horswill AR, Benkovic SJ, Maranas CD. FamClash: a method for ranking the activity of engineered enzymes. Proceedings of the National Academy of Sciences of the United States of America. 101: 4142-7. PMID 14981242 DOI: 10.1073/Pnas.0400065101  0.473
2003 Gulick AM, Starai VJ, Horswill AR, Homick KM, Escalante-Semerena JC. The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry. 42: 2866-73. PMID 12627952 DOI: 10.1021/Bi0271603  0.66
2002 Fonseca MV, Buan NR, Horswill AR, Rayment I, Escalante-Semerena JC. The ATP:Co(I)rrinoid adenosyltransferase (CobA) enzyme of Salmonella enterica requires the 2'-OH group of ATP for function and yields inorganic triphosphate as its reaction byproduct. The Journal of Biological Chemistry. 277: 33127-31. PMID 12080060 DOI: 10.1074/Jbc.M203893200  0.755
2002 Horswill AR, Escalante-Semerena JC. Characterization of the propionyl-CoA synthetase (PrpE) enzyme of Salmonella enterica: residue Lys592 is required for propionyl-AMP synthesis. Biochemistry. 41: 2379-87. PMID 11841231 DOI: 10.1021/Bi015647Q  0.689
2002 Gulick AM, Horswill AR, Thoden JB, Escalante-Semerena JC, Rayment I. Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase. Acta Crystallographica. Section D, Biological Crystallography. 58: 306-9. PMID 11807258 DOI: 10.1107/S0907444901018832  0.626
2001 Horswill AR, Dudding AR, Escalante-Semerena JC. Studies of propionate toxicity in Salmonella enterica identify 2-methylcitrate as a potent inhibitor of cell growth. The Journal of Biological Chemistry. 276: 19094-101. PMID 11376009 DOI: 10.1074/Jbc.M100244200  0.708
2001 Ciche TA, Bintrim SB, Horswill AR, Ensign JC. A Phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. Journal of Bacteriology. 183: 3117-26. PMID 11325940 DOI: 10.1128/Jb.183.10.3117-3126.2001  0.373
2001 Horswill AR, Escalante-Semerena JC. In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. Biochemistry. 40: 4703-13. PMID 11294638 DOI: 10.1021/Bi015503B  0.694
1999 Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Journal of Bacteriology. 181: 5615-23. PMID 10482501 DOI: 10.1128/Jb.181.18.5615-5623.1999  0.683
1999 Horswill AR, Escalante-Semerena JC. The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase. Microbiology (Reading, England). 145: 1381-8. PMID 10411265 DOI: 10.1099/13500872-145-6-1381  0.687
1998 Tsang AW, Horswill AR, Escalante-Semerena JC. Studies of regulation of expression of the propionate (prpBCDE) operon provide insights into how Salmonella typhimurium LT2 integrates its 1,2-propanediol and propionate catabolic pathways. Journal of Bacteriology. 180: 6511-8. PMID 9851993 DOI: 10.1128/Jb.180.24.6511-6518.1998  0.68
1997 Horswill AR, Escalante-Semerena JC. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Journal of Bacteriology. 179: 928-40. PMID 9006051 DOI: 10.1128/Jb.179.3.928-940.1997  0.68
1995 Rondon MR, Horswill AR, Escalante-Semerena JC. DNA polymerase I function is required for the utilization of ethanolamine, 1,2-propanediol, and propionate by Salmonella typhimurium LT2. Journal of Bacteriology. 177: 7119-24. PMID 8522518 DOI: 10.1128/Jb.177.24.7119-7124.1995  0.667
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