Jeffrey Aube - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
 Medicinal Chemistry University of Kansas, Lawrence, KS, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney E, Hackler A, Patrick S, Weiner WS, Aube J, Sharlow ER, Morris JC, Golden JE. Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1. Chemmedchem. PMID 29105342 DOI: 10.1002/cmdc.201700592  0.4
2015 Motiwala HF, Yin Q, Aubé J. Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules (Basel, Switzerland). 21. PMID 26729081 DOI: 10.3390/molecules21010045  0.72
2015 Motiwala HF, Vekariya RH, Aubé J. Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol. Organic Letters. 17: 5484-7. PMID 26496158 DOI: 10.1021/acs.orglett.5b02851  0.84
2015 Frankowski KJ, Liu R, Milligan GL, Moeller KD, Aubé J. Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization. Angewandte Chemie (International Ed. in English). 54: 10555-8. PMID 26371961 DOI: 10.1002/anie.201504775  0.6
2015 He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, et al. High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. Acs Combinatorial Science. PMID 26332742 DOI: 10.1021/acscombsci.5b00101  0.84
2015 Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology. PMID 26318102 DOI: 10.1016/j.neuropharm.2015.08.027  0.84
2015 Roy S, Šileikytė J, Schiavone M, Neuenswander B, Argenton F, Aubé J, Hedrick MP, Chung TD, Forte MA, Bernardi P, Schoenen FJ. Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore. Chemmedchem. PMID 26286375 DOI: 10.1002/cmdc.201500284  0.84
2015 Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, et al. A Pan-GTPase Inhibitor as a Molecular Probe. Plos One. 10: e0134317. PMID 26247207 DOI: 10.1371/journal.pone.0134317  0.84
2015 Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology. PMID 26160155 DOI: 10.1016/j.neuropharm.2015.07.001  0.84
2015 Fehl C, Hirt EE, Li SW, Aubé J. Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction. Tetrahedron Letters. 56: 3137-3140. PMID 26085693 DOI: 10.1016/j.tetlet.2014.12.068  0.84
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  0.84
2015 Lan L, Appelman C, Smith AR, Yu J, Larsen S, Marquez RT, Liu H, Wu X, Gao P, Roy A, Anbanandam A, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, et al. Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Molecular Oncology. PMID 25933687 DOI: 10.1016/j.molonc.2015.03.014  0.84
2015 Slauson SR, Pemberton R, Ghosh P, Tantillo DJ, Aubé J. Domino Acylation/Diels-Alder Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxylic Acids under Low-Solvent Conditions. The Journal of Organic Chemistry. 80: 5260-71. PMID 25901898 DOI: 10.1021/acs.joc.5b00804  0.84
2015 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias. Acs Chemical Neuroscience. PMID 25891774 DOI: 10.1021/acschemneuro.5b00092  0.84
2015 Wu X, Lan L, Wilson DM, Marquez RT, Tsao WC, Gao P, Roy A, Turner BA, McDonald P, Tunge JA, Rogers SA, Dixon DA, Aubé J, Xu L. Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction. Acs Chemical Biology. 10: 1476-84. PMID 25750985 DOI: 10.1021/cb500851u  0.84
2015 Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. Bioorganic & Medicinal Chemistry. 23: 3948-56. PMID 25593096 DOI: 10.1016/j.bmc.2014.12.033  0.84
2014 Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 5: 1278-1283. PMID 25530830 DOI: 10.1021/ml5003234  0.84
2014 Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aubé J, Plemper RK, Severson WE, Golden JE. Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity. Journal of Medicinal Chemistry. 57: 10314-28. PMID 25399509 DOI: 10.1021/jm500902x  0.84
2014 Jain P, Li J, Porubsky P, Neuenswander B, Egan SM, Aubé J, Rogers S. 3-Substituted Biquinolinium Inhibitors of AraC Family Transcriptional Activator VirF from S. flexneri Obtained Through In Situ Chemical Ionization of 3,4-Disubstituted Dihydroquinolines. Rsc Advances. 4: 39809-39816. PMID 25258678 DOI: 10.1039/C4RA08384A  0.84
2014 Schroeder CE, Yao T, Sotsky J, Smith RA, Roy S, Chu YK, Guo H, Tower NA, Noah JW, McKellip S, Sosa M, Rasmussen L, Smith LH, White EL, Aubé J, et al. Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. Journal of Medicinal Chemistry. 57: 8608-21. PMID 25244572 DOI: 10.1021/jm501203v  0.84
2014 Flaherty DP, Simpson DS, Miller M, Maki BE, Zou B, Shi J, Wu M, McManus OB, Aubé J, Li M, Golden JE. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorganic & Medicinal Chemistry Letters. 24: 3968-73. PMID 25017033 DOI: 10.1016/j.bmcl.2014.06.032  0.84
2014 Vekariya RH, Liu R, Aubé J. A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence. Organic Letters. 16: 1844-7. PMID 24635056 DOI: 10.1021/ol500011f  0.6
2014 McLeod MC, Singh G, Plampin JN, Rane D, Wang JL, Day VW, Aubé J. Probing chemical space with alkaloid-inspired libraries. Nature Chemistry. 6: 133-40. PMID 24451589 DOI: 10.1038/nchem.1844  0.84
2013 Motiwala HF, Bazzill J, Samadi A, Zhang H, Timmermann BN, Cohen MS, Aubé J. Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues. Acs Medicinal Chemistry Letters. 4. PMID 24273633 DOI: 10.1021/ml400267q  0.84
2013 Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Development of functionally selective, small molecule agonists at kappa opioid receptors. The Journal of Biological Chemistry. 288: 36703-16. PMID 24187130 DOI: 10.1074/jbc.M113.504381  0.84
2013 Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/jbc.M113.515668  0.84
2013 Motiwala HF, Fehl C, Li SW, Hirt E, Porubsky P, Aubé J. Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction. Journal of the American Chemical Society. 135: 9000-9. PMID 23687993 DOI: 10.1021/ja402848c  0.84
2013 Coombs TC, Tanega C, Shen M, Wang JL, Auld DS, Gerritz SW, Schoenen FJ, Thomas CJ, Aubé J. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorganic & Medicinal Chemistry Letters. 23: 3654-61. PMID 23642479 DOI: 10.1016/j.bmcl.2013.02.096  0.84
2013 Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, et al. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. The Journal of Biological Chemistry. 288: 8531-43. PMID 23382385 DOI: 10.1074/jbc.M112.435941  0.84
2013 Strouse JJ, Ivnitski-Steele I, Khawaja HM, Perez D, Ricci J, Yao T, Weiner WS, Schroeder CE, Simpson DS, Maki BE, Li K, Golden JE, Foutz TD, Waller A, Evangelisti AM, et al. A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. Journal of Biomolecular Screening. 18: 26-38. PMID 22923785 DOI: 10.1177/1087057112456875  0.84
2012 Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, Noah JW, Sosa MI, Ananthan S, Tower NA, White EL, Jia F, Prisinzano TE, Aubé J, Jonsson CB, et al. (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. Journal of Medicinal Chemistry. 55: 8582-7. PMID 23043370 DOI: 10.1021/jm300612z  0.84
2012 Motiwala HF, Gülgeze B, Aubé J. Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds. The Journal of Organic Chemistry. 77: 7005-22. PMID 22830300 DOI: 10.1021/jo3012336  0.84
2012 Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Acs Chemical Neuroscience. 3: 221-236. PMID 22737280 DOI: 10.1021/cn200128x  0.84
2012 Liu R, Gutierrez O, Tantillo DJ, Aubé J. Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction. Journal of the American Chemical Society. 134: 6528-31. PMID 22490078 DOI: 10.1021/ja300369c  0.6
2012 Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, Simpson DS, Schroeder CE, Oprea TI, Golden JE, Aubé J, Buranda T, Sklar LA, Wandinger-Ness A. A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. Acs Chemical Biology. 7: 1095-108. PMID 22486388 DOI: 10.1021/cb3001099  0.84
2012 Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN. Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. Journal of Medicinal Chemistry. 55: 3319-30. PMID 22409723 DOI: 10.1021/jm300021v  0.84
2012 Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, et al. Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. Acs Chemical Biology. 7: 715-22. PMID 22260433 DOI: 10.1021/cb200452r  0.88
2012 Seguin SP, Evans CW, Nebane-Akah M, McKellip S, Ananthan S, Tower NA, Sosa M, Rasmussen L, White EL, Maki BE, Matharu DS, Golden JE, Aubé J, Brodsky JL, Noah JW. High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. Journal of Biomolecular Screening. 17: 194-203. PMID 21948801 DOI: 10.1177/1087057111421630  0.84
2011 Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. The Journal of Organic Chemistry. 76: 9792-800. PMID 22007996 DOI: 10.1021/jo2018922  0.84
2011 Painter TO, Thornton PD, Orestano M, Santini C, Organ MG, Aubé J. In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 9595-8. PMID 21796690 DOI: 10.1002/chem.201100768  0.84
2011 Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proceedings of the National Academy of Sciences of the United States of America. 108: 6727-32. PMID 21368188 DOI: 10.1073/pnas.1016558108  0.36
2010 Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. Acs Medicinal Chemistry Letters. 1: 189-193. PMID 20729985 DOI: 10.1021/ml100040t  0.84
2010 Meyer AM, Katz CE, Li SW, Vander Velde D, Aubé J. A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C. Organic Letters. 12: 1244-7. PMID 20178342 DOI: 10.1021/ol100113r  0.84
2010 Szostak M, Yao L, Aubé J. Synthesis of medium-bridged twisted lactams via cation-pi control of the regiochemistry of the intramolecular Schmidt reaction. The Journal of Organic Chemistry. 75: 1235-43. PMID 20095596 DOI: 10.1021/jo902574m  0.84
2009 Huh CW, Somal GK, Katz CE, Pei H, Zeng Y, Douglas JT, Aubé J. One-pot synthesis of lactams using domino reactions: combination of Schmidt reaction with Sakurai and aldol reactions. The Journal of Organic Chemistry. 74: 7618-26. PMID 19761271 DOI: 10.1021/jo901843w  0.84
2009 Ghosh P, Judd WR, Ribelin T, Aubé J. Asymmetric total synthesis of alkaloids 223A and 6-epi-223A. Organic Letters. 11: 4140-2. PMID 19739687 DOI: 10.1021/ol901645j  0.84
2009 Szostak M, Aubé J. Corey-Chaykovsky epoxidation of twisted amides: synthesis and reactivity of bridged spiro-epoxyamines. Journal of the American Chemical Society. 131: 13246-7. PMID 19715274 DOI: 10.1021/ja906471q  0.84
2008 Frankowski KJ, Neuenswander B, Aubé J. Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification. Journal of Combinatorial Chemistry. 10: 721-5. PMID 18698827 DOI: 10.1021/cc800078h  0.84
2008 Ribelin T, Katz CE, English DG, Smith S, Manukyan AK, Day VW, Neuenswander B, Poutsma JL, Aubé J. Highly stereoselective ring expansion reactions mediated by attractive cation-n interactions. Angewandte Chemie (International Ed. in English). 47: 6233-5. PMID 18613179 DOI: 10.1002/anie.200801591  0.84
2008 Katz CE, Ribelin T, Withrow D, Basseri Y, Manukyan AK, Bermudez A, Nuera CG, Day VW, Powell DR, Poutsma JL, Aubé J. Nonbonded, attractive cation-pi interactions in azide-mediated asymmetric ring expansion reactions. The Journal of Organic Chemistry. 73: 3318-27. PMID 18396910 DOI: 10.1021/jo800222r  0.84
2008 Frankowski KJ, Golden JE, Zeng Y, Lei Y, Aubé J. Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction. Journal of the American Chemical Society. 130: 6018-24. PMID 18396881 DOI: 10.1021/ja800574m  0.84
2008 Nöth J, Frankowski KJ, Neuenswander B, Aubé J, Reiser O. Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. Journal of Combinatorial Chemistry. 10: 456-9. PMID 18338857 DOI: 10.1021/cc700202c  0.84
2008 Fenster E, Rayabarapu DK, Zhang M, Mukherjee S, Hill D, Neuenswander B, Schoenen F, Hanson PR, Aubé J. Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries. Journal of Combinatorial Chemistry. 10: 230-4. PMID 18254600 DOI: 10.1021/cc700174c  0.84
2008 Fenster E, Smith BT, Gracias V, Milligan GL, Aubé J. Nucleophilic addition to iminium ethers in the preparation of functionalized N-alkyl heterocycles. The Journal of Organic Chemistry. 73: 201-5. PMID 18069855 DOI: 10.1021/jo702193g  0.84
2007 Grecian S, Desai P, Mossman C, Poutsma JL, Aubé J. Reactions of cyclopropanone acetals with alkyl azides: Carbonyl addition versus ring-opening pathways Journal of Organic Chemistry. 72: 9439-9447. PMID 17985920 DOI: 10.1021/jo0711034  0.84
2007 Frankowski KJ, Hirt EE, Zeng Y, Neuenswander B, Fowler D, Schoenen F, Aubé J. Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence. Journal of Combinatorial Chemistry. 9: 1188-92. PMID 17896822 DOI: 10.1021/cc700127f  0.84
2006 Judd WR, Ban S, Aubé J. Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes. Journal of the American Chemical Society. 128: 13736-41. PMID 17044701 DOI: 10.1021/ja063411+  0.84
2005 Grecian S, Wrobleski AD, Aubé J. Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals. Organic Letters. 7: 3167-70. PMID 16018612 DOI: 10.1021/ol050715c  0.84
2005 Lei Y, Wrobleski AD, Golden JE, Powell DR, Aubé J. Facile C-N cleavage in a series of bridged lactams. Journal of the American Chemical Society. 127: 4552-3. PMID 15796502 DOI: 10.1021/ja050214m  0.84
2003 Katz CE, Aubé J. Unusual tethering effects in the Schmidt reaction of hydroxyalkyl azides with ketones: cation-pi and steric stabilization of a pseudoaxial phenyl group. Journal of the American Chemical Society. 125: 13948-9. PMID 14611217 DOI: 10.1021/ja0382361  0.84
2003 Reddy DS, Judd WR, Aubé J. Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones. Organic Letters. 5: 3899-902. PMID 14535738 DOI: 10.1021/ol0355130  0.84
2003 Sahasrabudhe K, Gracias V, Furness K, Smith BT, Katz CE, Reddy DS, Aubé J. Asymmetric Schmidt reaction of hydroxyalkyl azides with ketones. Journal of the American Chemical Society. 125: 7914-22. PMID 12823012 DOI: 10.1021/ja0348896  0.84
1999 Golden JE, Snider BB, Aube J, Lin H, Foxman BM. The first total synthesis of (-)-FR901483 Chemtracts. 12: 1026-1031.  0.84
1999 Vries T, Wynberg H, Van Echten E, Koek J, Ten Hoeve W, Kellogg RM, Broxterman QB, Minnaard A, Kaptein B, Van der Sluis S, Van Der Sluis S, Hulshof L, Kooistra J, Sahasrabudhe K, Aube J. The family approach to the resolution of racemates Chemtracts. 12: 672-674.  0.84
1997 Wolfe MS, Dutta D, Aube J. Stereoselective synthesis of Friedinger lactams using oxaziridines derived from amino acids Journal of Organic Chemistry. 62: 654-663. DOI: 10.1021/jo961670j  0.84
1995 Kitagawa O, Vander Velde D, Dutta D, Morton M, Takusagawa F, Aube J. Structural analysis of β-turn mimics containing a substituted 6-aminocaproic acid linker Journal of the American Chemical Society. 117: 5169-5178. DOI: 10.1021/ja00124a001  0.84
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