Seung B. Park, Ph.D. - Publications

Affiliations: 
2001 Texas A & M University, College Station, TX, United States 
Area:
Organic Chemistry, Biochemistry

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Byun WG, Lim D, Park SB. Discovery of small-molecule modulators of protein-RNA interactions by fluorescence intensity-based binding assay. Chembiochem : a European Journal of Chemical Biology. PMID 31587454 DOI: 10.1002/Cbic.201900467  0.335
2019 Jang JY, Kim H, Kim HJ, Suh SW, Park SB, Han BW. Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation. Scientific Reports. 9: 11168. PMID 31371757 DOI: 10.1038/S41598-019-47672-W  0.318
2019 Kim H, Song H, Park JG, Lee DS, Park SB. Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d. Acs Medicinal Chemistry Letters. 10: 773-779. PMID 31097998 DOI: 10.1021/Acsmedchemlett.9B00026  0.305
2019 Park H, Ha J, Park SB. Label-free target identification in drug discovery via phenotypic screening. Current Opinion in Chemical Biology. 50: 66-72. PMID 30933868 DOI: 10.1016/J.Cbpa.2019.02.006  0.304
2019 Choi Y, Kim H, Park SB. A divergent synthetic pathway for pyrimidine-embedded medium-sized azacycles through an N-quaternizing strategy. Chemical Science. 10: 569-575. PMID 30746098 DOI: 10.1039/C8Sc04061C  0.345
2018 Basso A, Park SB, Moni L. Editorial: Diversity Oriented Synthesis. Frontiers in Chemistry. 6: 668. PMID 30733940 DOI: 10.3389/Fchem.2018.00668  0.3
2018 Lim D, Byun WG, Park SB. Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein-RNA Interaction. Acs Medicinal Chemistry Letters. 9: 1181-1185. PMID 30613323 DOI: 10.1021/Acsmedchemlett.8B00323  0.313
2018 Yi S, Varun BV, Choi Y, Park SB. A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion. Frontiers in Chemistry. 6: 507. PMID 30406085 DOI: 10.3389/Fchem.2018.00507  0.347
2018 Shin YH, Park SB. Phenotype-Based High-Content Screening Using Fluorescent Chemical Bioprobes: Lipid Droplets and Glucose Uptake Quantification in Live Cells. Methods in Molecular Biology (Clifton, N.J.). 1787: 223-234. PMID 29736722 DOI: 10.1007/978-1-4939-7847-2_17  0.312
2018 Jang JY, Bae H, Lee YJ, Choi YI, Kim HJ, Park SB, Suh SW, Kim SW, Han BW. Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ. Scientific Reports. 8: 31. PMID 29311579 DOI: 10.1038/S41598-017-18274-1  0.31
2017 Park H, Ha J, Koo JY, Park J, Park SB. Label-free target identification using in-gel fluorescence difference via thermal stability shift. Chemical Science. 8: 1127-1133. PMID 28451252 DOI: 10.1039/C6Sc03238A  0.308
2017 Kim M, Hwang YS, Cho W, Park SB. Synthesis of 3,5-disubstituted isoxazoles containing privileged substructures with a diverse display of polar surface area. Acs Combinatorial Science. PMID 28306232 DOI: 10.1021/Acscombsci.7B00032  0.314
2016 Bae H, Jang JY, Choi SS, Lee JJ, Kim H, Jo A, Lee KJ, Choi JH, Suh SW, Park SB. Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands. Chemical Science. 7: 5523-5529. PMID 30034693 DOI: 10.1039/C6Sc01279E  0.303
2016 Kim C, Jung J, Tung TT, Park SB. β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase. Chemical Science. 7: 2753-2761. PMID 28660052 DOI: 10.1039/C5Sc03493K  0.337
2016 Kim J, Jung J, Koo J, Cho W, Lee WS, Kim C, Park W, Park SB. Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction. Nature Communications. 7: 13196. PMID 27774980 DOI: 10.1038/Ncomms13196  0.383
2016 Lee B, Park BG, Cho W, Lee HY, Olasz A, Chen CH, Park SB, Lee D. BOIMPY: Fluorescent Boron Complexes with Tunable and Environment-Responsive Light-Emitting Properties. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27754562 DOI: 10.1002/Chem.201603837  0.317
2016 Jo A, Jung J, Kim E, Park SB. A high-content screening platform with fluorescent chemical probes for the discovery of first-in-class therapeutics. Chemical Communications (Cambridge, England). PMID 27166145 DOI: 10.1039/C6Cc02587K  0.307
2016 Kim C, Jung J, Tung TT, Park SB. β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase Chemical Science. 7: 2753-2761. DOI: 10.1039/c5sc03493k  0.676
2015 Park J, Koh M, Koo JY, Lee S, Park SB. Investigation of Specific Binding Proteins to Photoaffinity Linkers for Efficient Deconvolution of Target Protein. Acs Chemical Biology. PMID 26502221 DOI: 10.1021/Acschembio.5B00671  0.308
2015 Kim E, Lee Y, Lee S, Park SB. Discovery, understanding, and bioapplication of organic fluorophore: a case study with an indolizine-based novel fluorophore, Seoul-Fluor. Accounts of Chemical Research. 48: 538-47. PMID 25695375 DOI: 10.1021/Ar500370V  0.304
2014 Kim J, Kim H, Park SB. Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces. Journal of the American Chemical Society. 136: 14629-38. PMID 25310802 DOI: 10.1021/Ja508343A  0.346
2014 Lee S, Nam Y, Koo JY, Lim D, Park J, Ock J, Kim J, Suk K, Park SB. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nature Chemical Biology. 10: 1055-60. PMID 25306442 DOI: 10.1038/Nchembio.1669  0.305
2014 Koh M, Park J, Koo JY, Lim D, Cha MY, Jo A, Choi JH, Park SB. Phenotypic screening to identify small-molecule enhancers for glucose uptake: target identification and rational optimization of their efficacy. Angewandte Chemie (International Ed. in English). 53: 5102-6. PMID 24692390 DOI: 10.1002/Anie.201310618  0.316
2014 Choi EJ, Kim E, Lee Y, Jo A, Park SB. Rational perturbation of the fluorescence quantum yield in emission-tunable and predictable fluorophores (Seoul-Fluors) by a facile synthetic method involving C-H activation. Angewandte Chemie (International Ed. in English). 53: 1346-50. PMID 24446281 DOI: 10.1002/Anie.201308826  0.306
2014 Kim J, Lee WS, Koo J, Lee J, Park SB. Synthesis and library construction of privileged tetra-substituted Δ5-2-oxopiperazine as β-turn structure mimetics. Acs Combinatorial Science. 16: 24-32. PMID 24215277 DOI: 10.1021/Co400128A  0.34
2014 Kim H, Tung TT, Park SB. ChemInform Abstract: Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles. Cheminform. 45: no-no. DOI: 10.1002/chin.201414185  0.701
2013 Kim H, Tung TT, Park SB. Privileged substructure-based diversity-oriented synthesis pathway for diverse pyrimidine-embedded polyheterocycles. Organic Letters. 15: 5814-7. PMID 24175659 DOI: 10.1021/Ol402872B  0.728
2013 Koo JY, Oh S, Cho SR, Koh M, Oh WK, Choi HS, Park SB. Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist. Organic & Biomolecular Chemistry. 11: 5782-6. PMID 23903931 DOI: 10.1039/C3Ob41264D  0.315
2013 Lim D, Park SB. Synthesis of molecular frameworks containing two distinct heterocycles connected in a single molecule with enhanced three-dimensional shape diversity Chemistry - a European Journal. 19: 7100-7108. PMID 23554106 DOI: 10.1002/Chem.201204293  0.347
2013 Park J, Koh M, Park SB. From noncovalent to covalent bonds: a paradigm shift in target protein identification. Molecular Biosystems. 9: 544-50. PMID 23354063 DOI: 10.1039/C2Mb25502B  0.308
2012 Park J, Oh S, Park SB. Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis. Angewandte Chemie (International Ed. in English). 51: 5447-51. PMID 22489056 DOI: 10.1002/Anie.201200609  0.319
2012 Song H, Lee H, Kim J, Park SB. Regioselective construction and screening of 1,3-disubstituted tetrahydroindazolones in enantiomerically pure pairs. Acs Combinatorial Science. 14: 66-74. PMID 22107604 DOI: 10.1021/Co200150D  0.333
2011 Oh S, Park SB. A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators Chemical Communications. 47: 12754-12761. PMID 21869959 DOI: 10.1039/C1Cc14042F  0.326
2011 Kim J, Song H, Park SB. Solid-phase parallel synthesis of a tetrahydroindazolone library containing three unique core skeletons. Chemistry, An Asian Journal. 6: 2062-72. PMID 21598402 DOI: 10.1002/Asia.201100145  0.333
2011 Srivastava AK, Koh M, Park SB. A synthetic route to highly substituted 1,2,3,4-tetrahydroisoquinolines via Yb(OTf)3 -catalyzed diastereoselective ring opening of bridged oxazolidines: asymmetric synthesis of 2-azapodophyllotoxin. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 4905-13. PMID 21404349 DOI: 10.1002/Chem.201002938  0.305
2011 Lee HY, Park SB. Surface modification for small-molecule microarrays and its application to the discovery of a tyrosinase inhibitor Molecular Biosystems. 7: 304-310. PMID 21079875 DOI: 10.1039/C0Mb00122H  0.314
2011 Koh M, Park SB. Computer-aided design and synthesis of tetra-aryl-substituted alkenes and their bioevaluation as a selective modulator of estrogen-related receptor γ. Molecular Diversity. 15: 69-81. PMID 20135221 DOI: 10.1007/S11030-010-9224-Y  0.339
2011 Oh S, Ko Y, Lee H, Kim J, Chung Y, Park S. Development of a FRET-based High-Throughput Screening System for the Discovery of Hsp90 Inhibitors Bulletin of the Korean Chemical Society. 32: 3229-3232. DOI: 10.5012/Bkcs.2011.32.9.3229  0.311
2011 Park S, Srivastava A, Song H. Diversity-Oriented Synthesis of Functionalized Polyheterocycles from Garner Aldehyde Synthesis. 2011: 2215-2222. DOI: 10.1055/S-0030-1260069  0.318
2010 Zhu M, Kim MH, Lee S, Bae SJ, Kim SH, Park SB. Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand. Journal of Medicinal Chemistry. 53: 8760-4. PMID 21114291 DOI: 10.1021/Jm1011269  0.333
2010 Oh S, Kim SJ, Hwang JH, Lee HY, Ryu MJ, Park J, Kim SJ, Jo YS, Kim YK, Lee CH, Kweon KR, Shong M, Park SB. Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase. Journal of Medicinal Chemistry. 53: 7405-13. PMID 20873794 DOI: 10.1021/Jm100565D  0.306
2010 Lee HY, Park SB. Small molecule microarray: functional-group specific immobilization of small molecules Methods in Molecular Biology (Clifton, N.J.). 669: 23-42. PMID 20857355 DOI: 10.1007/978-1-60761-845-4_3  0.318
2010 Oh S, Jang HJ, Ko SK, Ko Y, Park SB. Construction of a polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway. Journal of Combinatorial Chemistry. 12: 548-58. PMID 20515049 DOI: 10.1021/Cc100044W  0.32
2010 Kim J, Song H, Park SB. Orthogonal Regioselective Synthesis of N-Alkyl-3-substituted Tetrahydroindazolones European Journal of Organic Chemistry. 2010: 3815-3822. DOI: 10.1002/Ejoc.201000516  0.302
2009 Kim Y, Koh M, Kim DK, Choi HS, Park SB. Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach. Journal of Combinatorial Chemistry. 11: 928-37. PMID 19746993 DOI: 10.1021/Cc900081J  0.33
2009 Xie YB, Park JH, Kim DK, Hwang JH, Oh S, Park SB, Shong M, Lee IK, Choi HS. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. The Journal of Biological Chemistry. 284: 28762-74. PMID 19690166 DOI: 10.1074/Jbc.M109.034165  0.303
2009 Park SO, Kim J, Koh M, Park SB. Efficient parallel synthesis of privileged benzopyranylpyrazoles via regioselective condensation of beta-keto aldehydes with hydrazines. Journal of Combinatorial Chemistry. 11: 315-26. PMID 19199788 DOI: 10.1021/Cc800197S  0.302
2008 Kim B, Lee M, Kim MJ, Lee H, Kim S, Kim D, Koh M, Park SB, Shin KJ. Biomimetic asymmetric total synthesis of (-)-laurefucin via an organoselenium-mediated intramolecular hydroxyetherification. Journal of the American Chemical Society. 130: 16807-11. PMID 19049472 DOI: 10.1021/Ja806304S  0.323
2008 Sagar R, Park SB. Facile and efficient synthesis of carbohybrids as stereodivergent druglike small molecules Journal of Organic Chemistry. 73: 3270-3273. PMID 18351781 DOI: 10.1021/Jo800190V  0.305
2008 An H, Eum SJ, Koh M, Lee SK, Park SB. Diversity-oriented synthesis of privileged benzopyranyl heterocycles from s-cis-enones. The Journal of Organic Chemistry. 73: 1752-61. PMID 18266382 DOI: 10.1021/Jo702196F  0.324
2007 Lee SC, Park SB. Novel application of Leuckart-Wallach reaction for synthesis of tetrahydro-1,4-benzodiazepin-5-ones library Chemical Communications. 3714-3716. PMID 17851604 DOI: 10.1039/B709768A  0.325
2006 Standaert RF, Park SB. Abc amino acids: design, synthesis, and properties of new photoelastic amino acids. The Journal of Organic Chemistry. 71: 7952-66. PMID 17025282 DOI: 10.1021/Jo060763Q  0.624
2006 Ko SK, Jang HJ, Kim E, Park SB. Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif. Chemical Communications (Cambridge, England). 2962-4. PMID 16832504 DOI: 10.1039/B606341A  0.36
2006 Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. A robust small-molecule microarray platform for screening cell lysates. Chemistry & Biology. 13: 493-504. PMID 16720270 DOI: 10.1016/J.Chembiol.2006.03.004  0.492
2006 Lee SC, Park SB. Solid-phase parallel synthesis of natural product-like diaza-bridged heterocycles through Pictet-Spengler intramolecular cyclization Journal of Combinatorial Chemistry. 8: 50-57. PMID 16398553 DOI: 10.1021/Cc0501054  0.317
2006 Lee S, Choi SY, Chung YK, Park SB. Preparation of pilot library with tetrahydro-β-carboline alkaloid core skeleton using tandem intramolecular Pictet–Spengler cyclization Tetrahedron Letters. 47: 6843-6847. DOI: 10.1016/J.Tetlet.2006.07.051  0.317
2005 Fontes MR, Teh T, Riell RD, Park SB, Standaert RF, Kobe B. Crystallization and preliminary X-ray diffraction analysis of importin-alpha complexed with NLS peptidomimetics. Biochimica Et Biophysica Acta. 1750: 9-13. PMID 15878698 DOI: 10.1016/J.Bbapap.2005.03.014  0.599
2003 Park SB, Ho TH, Reedy BM, Connolly MD, Standaert RF. Simple mimetics of a nuclear localization signal (NLS). Organic Letters. 5: 2437-40. PMID 12841749 DOI: 10.1021/Ol034640T  0.62
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands. Angewandte Chemie (International Ed. in English). 42: 2376-9. PMID 12783500 DOI: 10.1002/Anie.200351043  0.46
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Cover Picture: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. Int. Ed. 21/2003) Angewandte Chemie International Edition. 42: 2319-2319. DOI: 10.1002/Anie.200390464  0.459
2003 Barnes-Seeman D, Park SB, Koehler AN, Schreiber SL. Titelbild: Expanding the Functional Group Compatibility of Small-Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. 21/2003) Angewandte Chemie. 115: 2421-2421. DOI: 10.1002/Ange.200390491  0.46
2002 Kwon O, Park SB, Schreiber SL. Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions. Journal of the American Chemical Society. 124: 13402-4. PMID 12418890 DOI: 10.1021/Ja028086E  0.472
2001 Park SB, Standaert RF. A photoregulated ligand for the nuclear import receptor karyopherin alpha. Bioorganic & Medicinal Chemistry. 9: 3215-23. PMID 11711297 DOI: 10.1016/S0968-0896(01)00230-9  0.615
2000 Park SB, Reedy BM, Standaert RF. A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 2: competitive binding. Bioorganic & Medicinal Chemistry Letters. 10: 955-6. PMID 10853667 DOI: 10.1016/S0960-894X(00)00135-9  0.589
2000 Connolly MD, Park SB, Reedy BM, Standaert RF. A simple, solid-phase binding assay for the nuclear import receptor karyopherin alpha. Part 1: direct binding. Bioorganic & Medicinal Chemistry Letters. 10: 951-4. PMID 10853666 DOI: 10.1016/S0960-894X(00)00134-7  0.596
1999 Park SB, Standaert RF. α,α-difluorophosphonomethyl azobenzene derivatives as photoregulated phosphoamino acid analogs. 1. Design and synthesis Tetrahedron Letters. 40: 6557-6560. DOI: 10.1016/S0040-4039(99)01400-8  0.59
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