Thomas A. Gasiewicz - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Toxicology, Biochemistry

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bennett JA, Singh KP, Welle SL, Boule LA, Lawrence BP, Gasiewicz TA. Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells. Plos One. 13: e0206407. PMID 30388136 DOI: 10.1371/journal.pone.0206407  0.44
2017 Gasiewicz TA, Singh KP, Casado FL. Aryl Hydrocarbon Receptor and Stem Cells. Stem Cells International. 2017: 4602854. PMID 28163722 DOI: 10.1155/2017/4602854  0.44
2016 Unnisa Z, Singh KP, Henry EC, Donegan CL, Bennett JA, Gasiewicz TA. Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells. Stem Cells International. 2016: 4536187. PMID 27366154 DOI: 10.1155/2016/4536187  1
2015 Bennett JA, Singh KP, Unnisa Z, Welle SL, Gasiewicz TA. Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells. Plos One. 10: e0133791. PMID 26208102 DOI: 10.1371/Journal.Pone.0133791  1
2015 Moses MA, Henry EC, Ricke WA, Gasiewicz TA. The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model. Cancer Prevention Research (Philadelphia, Pa.). 8: 249-57. PMID 25604133 DOI: 10.1158/1940-6207.Capr-14-0224  1
2014 Bhat R, Adam AT, Lee JJ, Gasiewicz TA, Henry EC, Rotella DP. Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2263-6. PMID 24745965 DOI: 10.1016/J.Bmcl.2014.03.088  1
2014 Gasiewicz TA, Singh KP, Bennett JA. The Ah receptor in stem cell cycling, regulation, and quiescence. Annals of the New York Academy of Sciences. 1310: 44-50. PMID 24495120 DOI: 10.1111/Nyas.12361  1
2014 Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL, Gasiewicz TA. Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice. Stem Cells and Development. 23: 95-106. PMID 24138668 DOI: 10.1089/Scd.2013.0346  1
2011 Casado FL, Singh KP, Gasiewicz TA. Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration. Molecular Pharmacology. 80: 673-82. PMID 21791576 DOI: 10.1124/Mol.111.071381  1
2011 Singh KP, Garrett RW, Casado FL, Gasiewicz TA. Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions. Stem Cells and Development. 20: 769-84. PMID 20874460 DOI: 10.1089/Scd.2010.0333  1
2011 Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA. Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Stem Cells and Development. 20: 313-26. PMID 20486776 DOI: 10.1089/Scd.2009.0529  1
2011 Gasiewicz TA, Henry EC. History of Research on the AHR The Ah Receptor in Biology and Toxicology. 1-32. DOI: 10.1002/9781118140574.ch1  1
2010 Casado FL, Singh KP, Gasiewicz TA. The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases. Blood Cells, Molecules & Diseases. 44: 199-206. PMID 20171126 DOI: 10.1016/J.Bcmd.2010.01.005  1
2010 Laiosa MD, Mills JH, Lai ZW, Singh KP, Middleton FA, Gasiewicz TA, Silverstone AE. Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation. Molecular Pharmacology. 77: 773-83. PMID 20159946 DOI: 10.1124/Mol.109.062497  1
2010 Henry EC, Welle SL, Gasiewicz TA. TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts. Toxicological Sciences : An Official Journal of the Society of Toxicology. 114: 90-100. PMID 19933214 DOI: 10.1093/Toxsci/Kfp285  1
2010 Gasiewicz TA, Singh KP, Casado FL. The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity. Chemico-Biological Interactions. 184: 246-51. PMID 19896476 DOI: 10.1016/J.Cbi.2009.10.019  1
2009 Yin Z, Henry EC, Gasiewicz TA. (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. Biochemistry. 48: 336-45. PMID 19113837 DOI: 10.1021/Bi801637Q  1
2009 Singh KP, Casado FL, Opanashuk LA, Gasiewicz TA. The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations. Biochemical Pharmacology. 77: 577-87. PMID 18983985 DOI: 10.1016/J.Bcp.2008.10.001  1
2009 Singh KP, Wyman A, Casado FL, Garrett RW, Gasiewicz TA. Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells. Carcinogenesis. 30: 11-9. PMID 18820284 DOI: 10.1093/Carcin/Bgn224  1
2008 Vezina CM, Allgeier SH, Moore RW, Lin TM, Bemis JC, Hardin HA, Gasiewicz TA, Peterson RE. Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate. Toxicological Sciences : An Official Journal of the Society of Toxicology. 106: 488-96. PMID 18779384 DOI: 10.1093/Toxsci/Kfn183  1
2008 Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. The Journal of Biological Chemistry. 283: 28944-57. PMID 18697742 DOI: 10.1074/Jbc.M800685200  1
2008 Gasiewicz TA, Henry EC, Collins LL. Expression and activity of aryl hydrocarbon receptors in development and cancer. Critical Reviews in Eukaryotic Gene Expression. 18: 279-321. PMID 18652561 DOI: 10.1615/Critreveukargeneexpr.V18.I4.10  1
2008 Henry EC, Gasiewicz TA. Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics. 472: 77-88. PMID 18294953 DOI: 10.1016/J.Abb.2008.02.005  1
2008 Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. 2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 125-36. PMID 18227101 DOI: 10.1093/Toxsci/Kfn017  1
2007 Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1571-80. PMID 17576166 DOI: 10.1359/Jbmr.070615  1
2007 Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. The American Journal of Pathology. 170: 855-64. PMID 17322371 DOI: 10.2353/Ajpath.2007.060391  1
2007 Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA. TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicological Sciences : An Official Journal of the Society of Toxicology. 95: 240-8. PMID 17035482 DOI: 10.1093/Toxsci/Kfl132  1
2006 Garrett RW, Gasiewicz TA. The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells. Molecular Pharmacology. 69: 2076-83. PMID 16556773 DOI: 10.1124/Mol.105.021006  1
2006 Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo. Archives of Biochemistry and Biophysics. 450: 67-77. PMID 16545771 DOI: 10.1016/J.Abb.2006.02.008  1
2006 Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, Suh PG. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Molecular Pharmacology. 69: 1871-8. PMID 16540597 DOI: 10.1124/Mol.105.021832  1
2005 Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine. 11: 959-65. PMID 16116430 DOI: 10.1038/Nm1287  1
2005 Bemis JC, Nazarenko DA, Gasiewicz TA. Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines. Toxicological Sciences : An Official Journal of the Society of Toxicology. 87: 529-36. PMID 16033994 DOI: 10.1093/Toxsci/Kfi260  1
2005 Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts American Journal of Physiology - Lung Cellular and Molecular Physiology. 289: L391-L399. PMID 15863442 DOI: 10.1152/Ajplung.00062.2005  1
2005 Palermo CM, Westlake CA, Gasiewicz TA. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry. 44: 5041-52. PMID 15794642 DOI: 10.1021/Bi047433P  1
2005 Williamson MA, Gasiewicz TA, Opanashuk LA. Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 340-8. PMID 15537747 DOI: 10.1093/Toxsci/Kfi031  1
2004 Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 25: 605-16. PMID 15183014 DOI: 10.1016/J.Neuro.2003.08.007  1
2004 Minsavage GD, Park SK, Gasiewicz TA. The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation. The Journal of Biological Chemistry. 279: 20582-93. PMID 14978034 DOI: 10.1074/Jbc.M312977200  1
2003 Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA, Reiners JJ. The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1279-82. PMID 14570754 DOI: 10.1124/Dmd.31.11.1279  1
2003 Laiosa MD, Wyman A, Murante FG, Fiore NC, Staples JE, Gasiewicz TA, Silverstone AE. Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor. Journal of Immunology (Baltimore, Md. : 1950). 171: 4582-91. PMID 14568932 DOI: 10.4049/Jimmunol.171.9.4582  1
2003 Palermo CM, Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA. Identification of potential aryl hydrocarbon receptor antagonists in green tea. Chemical Research in Toxicology. 16: 865-72. PMID 12870889 DOI: 10.1021/Tx025672C  1
2003 Zhou J, Gasiewicz TA. 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism. Archives of Biochemistry and Biophysics. 416: 68-80. PMID 12859983 DOI: 10.1016/S0003-9861(03)00274-1  1
2003 Minsavage GD, Vorojeikina DP, Gasiewicz TA. Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements. Archives of Biochemistry and Biophysics. 412: 95-105. PMID 12646272 DOI: 10.1016/S0003-9861(03)00033-X  1
2003 Zhou JG, Henry EC, Palermo CM, Dertinger SD, Gasiewicz TA. Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Molecular Pharmacology. 63: 915-24. PMID 12644593 DOI: 10.1124/Mol.63.4.915  1
2003 Henry EC, Gasiewicz TA. Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis. Molecular Pharmacology. 63: 392-400. PMID 12527811 DOI: 10.1124/Mol.63.2.392  1
2002 Laiosa MD, Lai ZW, Thurmond TS, Fiore NC, DeRossi C, Holdener BC, Gasiewicz TA, Silverstone AE. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicological Sciences : An Official Journal of the Society of Toxicology. 69: 117-24. PMID 12215665 DOI: 10.1093/Toxsci/69.1.117  1
2002 Wyman A, Lavin AL, Wilding GE, Gasiewicz TA. 2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system. Toxicology and Applied Pharmacology. 180: 164-77. PMID 12009856 DOI: 10.1006/Taap.2002.9396  1
2001 Nazarenko DA, Dertinger SD, Gasiewicz TA. In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 61: 256-64. PMID 11353134 DOI: 10.1093/Toxsci/61.2.256  1
2001 Nazarenko DA, Dertinger SD, Gasiewicz TA. Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates. Biotechniques. 30: 776-7, 780-1. PMID 11314260 DOI: 10.2144/01304St03  1
2001 Dertinger SD, Nazarenko DA, Silverstone AE, Gasiewicz TA. Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo. Carcinogenesis. 22: 171-7. PMID 11159756 DOI: 10.1093/Carcin/22.1.171  1
2000 Thurmond TS, Murante FG, Staples JE, Silverstone AE, Korach KS, Gasiewicz TA. Role of Estrogen Receptor α in Hematopoietic Stem Cell Development and B Lymphocyte Maturation in the Male Mouse. Endocrinology. 141: 2309-2318. PMID 28201025 DOI: 10.1210/endo.141.7.7560  1
2000 Gasiewicz TA, Thurmond TS, Staples JE, Murante FG, Silverstone AE. Use of bone marrow chimeras to identify cell targets in the immune system for the actions of chemicals. Annals of the New York Academy of Sciences. 919: 300-3. PMID 11083120 DOI: 10.1111/J.1749-6632.2000.Tb06890.X  1
2000 Thurmond TS, Gasiewicz TA. A single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile Toxicological Sciences. 58: 88-95. PMID 11053544 DOI: 10.1093/Toxsci/58.1.88  1
2000 Park S, Henry EC, Gasiewicz TA. Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation. Archives of Biochemistry and Biophysics. 381: 302-12. PMID 11032419 DOI: 10.1006/Abbi.2000.1999  1
2000 Lai ZW, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicology and Applied Pharmacology. 168: 15-24. PMID 11000096 DOI: 10.1006/Taap.2000.9015  1
2000 Thurmond TS, Murante FG, Staples JE, Silverstone AE, Korach KS, Gasiewicz TA. Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology. 141: 2309-18. PMID 10875230 DOI: 10.1210/Endo.141.7.7560  1
2000 Thurmond TS, Staples JE, Silverstone AE, Gasiewicz TA. The aryl hydrocarbon receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8- tetrachlorodibenzo-p-dioxin Toxicology and Applied Pharmacology. 165: 227-236. PMID 10860871 DOI: 10.1006/Taap.2000.8942  1
2000 Dertinger SD, Lantum HB, Silverstone AE, Gasiewicz TA. Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms. Biochemical Pharmacology. 60: 189-96. PMID 10825463 DOI: 10.1016/S0006-2952(00)00314-2  1
2000 Murante FG, Gasiewicz TA. Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 54: 374-83. PMID 10774819 DOI: 10.1093/Toxsci/54.2.374  1
2000 Dertinger SD, Torous DK, Hall NE, Tometsko CR, Gasiewicz TA. Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry. Mutation Research. 464: 195-200. PMID 10648906 DOI: 10.1016/S1383-5718(99)00183-7  1
1999 Yudt MR, Vorojeikina D, Zhong L, Skafar DF, Sasson S, Gasiewicz TA, Notides AC. Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation Biochemistry. 38: 14146-14156. PMID 10571988 DOI: 10.1021/Bi9911132  1
1999 Staples JE, Gasiewicz TA, Fiore NC, Lubahn DB, Korach KS, Silverstone AE. Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations. Journal of Immunology (Baltimore, Md. : 1950). 163: 4168-74. PMID 10510352  1
1999 Thurmond TS, Silverstone AE, Baggs RB, Quimby FW, Staples JE, Gasiewicz TA. A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology and Applied Pharmacology. 158: 33-40. PMID 10387930 DOI: 10.1006/Taap.1999.8681  1
1999 Henry EC, Kende AS, Rucci G, Totleben MJ, Willey JJ, Dertinger SD, Pollenz RS, Jones JP, Gasiewicz TA. Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation. Molecular Pharmacology. 55: 716-25. PMID 10101030  1
1998 Dertinger SD, Silverstone AE, Gasiewicz TA. Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate. Carcinogenesis. 19: 2037-42. PMID 9855021 DOI: 10.1093/Carcin/19.11.2037  1
1998 Staples JE, Fiore NC, Frazier DE, Gasiewicz TA, Silverstone AE. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. 151: 200-10. PMID 9705904 DOI: 10.1006/taap.1998.8446  1
1998 Willey JJ, Stripp BR, Baggs RB, Gasiewicz TA. Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice Toxicology and Applied Pharmacology. 151: 33-44. PMID 9705885 DOI: 10.1006/Taap.1998.8444  1
1998 Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture. Toxicology and Applied Pharmacology. 149: 167-77. PMID 9571985 DOI: 10.1006/Taap.1998.8368  1
1998 Staples JE, Murante FG, Fiore NC, Gasiewicz TA, Silverstone AE. Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. Journal of Immunology (Baltimore, Md. : 1950). 160: 3844-54. PMID 9558089  1
1998 Lavin AL, Hahn DJ, Gasiewicz TA. Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells. Archives of Biochemistry and Biophysics. 352: 9-18. PMID 9521805 DOI: 10.1006/Abbi.1998.0587  1
1997 Gasiewicz TA. Dioxins and the Ah receptor: Probes to uncover processes in neuroendocrine development Neurotoxicology. 18: 393-414. PMID 9291490  1
1997 Henry EC, Kent TA, Gasiewicz TA. DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex. Archives of Biochemistry and Biophysics. 339: 305-14. PMID 9056263 DOI: 10.1006/Abbi.1996.9873  1
1997 Gasiewicz TA. Exposure to dioxin and dioxin-like compounds as a potential factor in developmental disabilities Mental Retardation and Developmental Disabilities Research Reviews. 3: 230-238. DOI: 10.1002/(Sici)1098-2779(1997)3:3<230::Aid-Mrdd3>3.0.Co;2-T  1
1996 Gasiewicz TA, Kende AS, Rucci G, Whitney B, Willey JJ. Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds. Biochemical Pharmacology. 52: 1787-803. PMID 8986142 DOI: 10.1016/S0006-2952(96)00600-4  1
1996 Germolec DR, Henry EC, Maronpot R, Foley JF, Adams NH, Gasiewicz TA, Luster MI. Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD). Toxicology and Applied Pharmacology. 137: 57-66. PMID 8607142 DOI: 10.1006/Taap.1996.0057  1
1995 Mahon MJ, Gasiewicz TA. Ah receptor phosphorylation: Localization of phosphorylation sites to the C-terminal half of the protein Archives of Biochemistry and Biophysics. 318: 166-174. PMID 7726558 DOI: 10.1006/Abbi.1995.1217  1
1995 White TEK, Rucci G, Liu Z, Gasiewicz TA. Weanling female Sprague-Dawley rats are not sensitive to the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Toxicology and Applied Pharmacology. 133: 313-320. PMID 7645028 DOI: 10.1006/Taap.1995.1156  1
1995 DeVito MJ, Birnbaum LS, Farland WH, Gasiewicz TA. Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals Environmental Health Perspectives. 103: 820-831. PMID 7498094 DOI: 10.1289/Ehp.95103820  1
1994 Frazier DE, Silverstone AE, Soults JA, Gasiewicz TA. The thymus does not mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin-elicited alterations in bone marrow lymphocyte stem cells Toxicology and Applied Pharmacology. 124: 242-247. PMID 8122269 DOI: 10.1006/Taap.1994.1028  1
1994 Frazier DE, Silverstone AE, Gasiewicz TA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor Biochemical Pharmacology. 47: 2039-2048. PMID 8010988 DOI: 10.1016/0006-2952(94)90079-5  1
1994 Bradfield CA, Gallo MA, Gasiewicz TA, Greenberg RS, Greenlee WF, Margolick J, Mattison DR, Munson P, Neal RA, Okey AB. EPA dioxin reassessment. Science (New York, N.Y.). 266: 1628-9. PMID 7992038 DOI: 10.1126/Science.7992038  1
1994 Silverstone AE, Frazier DE, Gasiewicz TA. Alternate immune system targets for TCDD: Lymphocyte stem cells and extrathymic T-cell development Experimental and Clinical Immunogenetics. 11: 94-101. PMID 7826670 DOI: 10.1159/000424198  1
1994 Henry EC, Rucci G, Gasiewicz TA. Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver. Molecular Pharmacology. 46: 1022-7. PMID 7808420  1
1994 Silverstone AE, Frazier DE, Fiore NC, Soults JA, Gasiewicz TA. Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicology and Applied Pharmacology. 126: 248-59. PMID 7516097 DOI: 10.1006/Taap.1994.1114  1
1993 Henry EC, Gasiewicz TA. Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin. The Biochemical Journal. 294: 95-101. PMID 8395819 DOI: 10.1042/Bj2940095  1
1993 White TEK, Gasiewicz TA. The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: A possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin Biochemical and Biophysical Research Communications. 193: 956-962. PMID 8391813 DOI: 10.1006/Bbrc.1993.1718  1
1992 Mahon MJ, Gasiewicz TA. Chelatable metal ions are not required for aryl hydrocarbon receptor transformation to a DNA binding form: Phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin Archives of Biochemistry and Biophysics. 297: 1-8. PMID 1322109 DOI: 10.1016/0003-9861(92)90633-8  1
1992 Silverstone AE, Fiore NC, Soults JA, Cunningham LM, Gasiewicz TA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin effects on lymphocyte stem cells: Comparisons with corticosteroids and estrogens Chemosphere. 25: 103-106. DOI: 10.1016/0045-6535(92)90490-I  1
1991 Hahn ME, Gasiewicz TA. Determination of individual porphyrins in rodent urine using high-performance liquid chromatography following clean-up by anion-exchange chromatography Journal of Chromatography B: Biomedical Sciences and Applications. 563: 363-368. PMID 2056000 DOI: 10.1016/0378-4347(91)80043-C  1
1991 Gasiewicz TA, Elferink CJ, Henry EC. Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation. Biochemistry. 30: 2909-16. PMID 1848780 DOI: 10.1021/Bi00225A026  1
1991 Henry EC, Hayden KA, Bauman PA, Gasiewicz TA. Ribonuclease inhibits Ah receptor transformation in vitro. The Biochemical Journal. 279: 689-94. PMID 1659385 DOI: 10.1042/Bj2790689  1
1991 Gasiewicz TA, Rucci G. α-Naphthoflavone acts as an antagonist of 2,3,7,8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor Molecular Pharmacology. 40: 607-612. PMID 1658599  1
1991 Henry EC, Gasiewicz TA. Inhibition and reconstitution of Ah receptor transformation in vitro: role and partial characterization of a cytosolic factor(s). Archives of Biochemistry and Biophysics. 288: 149-56. PMID 1654820 DOI: 10.1016/0003-9861(91)90177-K  1
1990 Fine JS, Silverstone AE, Gasiewicz TA. Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin Journal of Immunology. 144: 1169-1176. PMID 2303704  1
1990 Fine JS, Gasiewicz TA, Fiore NC, Silverstone AE. Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. The Journal of Pharmacology and Experimental Therapeutics. 255: 128-32. PMID 2213547  1
1990 Elferink CJ, Gasiewicz TA, Whitlock JP. Protein-DNA interactions at a dioxin-responsive enhancer: Evidence that the transformed Ah receptor is heteromeric Journal of Biological Chemistry. 265: 20708-20712. PMID 2173716  1
1990 Ryan JJ, Gasiewicz TA, Brown JF. Human body burden of polychlorinated dibenzofurans associated with toxicity based on the yusho and yucheng incidents Toxicological Sciences. 15: 722-731. DOI: 10.1016/0272-0590(90)90188-P  1
1989 Fine JS, Gasiewicz TA, Silverstone AE. Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin Molecular Pharmacology. 35: 18-25. PMID 2783621  1
1989 Ackermann MF, Gasiewicz TA, Lamm KR, Germolec DR, Luster MI. Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology and Applied Pharmacology. 101: 470-480. PMID 2557688 DOI: 10.1016/0041-008X(89)90195-6  1
1989 Henry EC, Rucci G, Gasiewicz TA. Characterization of multiple forms of the Ah receptor: comparison of species and tissues. Biochemistry. 28: 6430-40. PMID 2551374 DOI: 10.1021/Bi00441A041  1
1989 Hahn ME, Goldstein JA, Linko P, Gasiewicz TA. Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo,. Evidence that hexachlorobenzene is a weak Ah receptor agonist Archives of Biochemistry and Biophysics. 270: 344-355. PMID 2539049 DOI: 10.1016/0003-9861(89)90037-4  1
1988 Hahn ME, Gasiewicz TA, Linko P, Goldstein JA. The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice Biochemical Journal. 254: 245-254. PMID 2845946 DOI: 10.1042/Bj2540245  1
1988 Rucci G, Gasiewicz TA. In vivo kinetics and DNA-binding properties of the Ah receptor in the golden syrian hamster Archives of Biochemistry and Biophysics. 265: 197-207. PMID 2843101 DOI: 10.1016/0003-9861(88)90385-2  1
1988 Henry EC, Kester JE, Gasiewicz TA. Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex. Biochimica Et Biophysica Acta. 964: 361-76. PMID 2831991 DOI: 10.1016/0304-4165(88)90037-2  1
1987 Henry EC, Gasiewicz TA. Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and Applied Pharmacology. 89: 165-74. PMID 3111013 DOI: 10.1016/0041-008X(87)90037-8  1
1987 Kester JE, Gasiewicz TA. Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding capacity of the rat hepatic Ah receptor Bba - General Subjects. 925: 109-116. PMID 3040108 DOI: 10.1016/0304-4165(87)90099-7  1
1987 Gasiewicz TA, Bauman PA. Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo Journal of Biological Chemistry. 262: 2116-2120. PMID 3029065  1
1987 Kester JE, Gasiewicz TA. Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Archives of Biochemistry and Biophysics. 252: 606-625. PMID 3028272 DOI: 10.1016/0003-9861(87)90067-1  1
1987 Hahn ME, Gasiewicz TA, Linko P, Goldstein JA. Studies on the role of the Ah receptor in hexachlorobenzene-induced porphyria Annals of the New York Academy of Sciences. 514: 333-334. DOI: 10.1111/J.1749-6632.1987.Tb48791.X  1
1987 Schecter A, Gasiewicz TA. Health hazard assessment of chlorinated dioxins and dibenzofurans contained in human milk Chemosphere. 16: 2147-2154. DOI: 10.1016/0045-6535(87)90223-2  1
1986 Goldstein JA, Linko P, Hahn ME, Gasiewicz TA, Yeowell HN. Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat Iarc Scientific Publications. 519-526. PMID 3596751  1
1986 Gasiewicz TA, Rucci G, Henry EC, Baggs RB. Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P): menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity. Biochemical Pharmacology. 35: 2737-42. PMID 3091031 DOI: 10.1016/0006-2952(86)90183-8  1
1986 Lu CJH, Redmond D, Baggs RB, Schecter A, Gasiewicz TA. Growth and hepatic composition in the guinea pig after long-term parenteral hyperalimentation American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 251: 20/2. PMID 3090899 DOI: 10.1152/Ajpregu.1986.251.2.R388  1
1986 Huang Lu CJ, Baggs RB, Redmond D, Henry EC, Schecter A, Gasiewicz TA. Toxicity and evidence for metabolic alterations in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated guinea pigs fed by total parenteral nutrition. Toxicology and Applied Pharmacology. 84: 439-53. PMID 3088772 DOI: 10.1016/0041-008X(86)90249-8  1
1986 Henry EC, Gasiewicz TA. Effects of thyroidectomy on the Ah receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver. Chemico-Biological Interactions. 59: 29-42. PMID 3019582 DOI: 10.1016/S0009-2797(86)80053-9  1
1986 Linko P, Yeowell HN, Gasiewicz TA, Goldstein JA. Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice Journal of Biochemical Toxicology. 1: 95-107. PMID 2856071 DOI: 10.1002/Jbt.2570010209  1
1986 Gasiewicz TA, Henry EC, Baggs RB, Rucci G, Schecter A. Temporal - and dose-related characteristics of biochemical and morphological alterations in the hamster induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin Chemosphere. 15: 1749-1752. DOI: 10.1016/0045-6535(86)90463-7  1
1986 Hahn ME, Gasiewicz TA, Goldstein JA, Linko P. Effect of hexachlorobenzene on the specific binding of 2,3,7,8,-TCDD to the hepatic Ah receptor Chemosphere. 15: 1691-1698. DOI: 10.1016/0045-6535(86)90456-X  1
1986 Sweatlock JA, Gasiewicz TA. The interaction of 1,3-diaryltriazenes with the Ah receptor Chemosphere. 15: 1687-1690. DOI: 10.1016/0045-6535(86)90455-8  1
1985 Sweatlock JA, Gasiewicz TA. The effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure on the concentration of B-hydroxybutyrate and acetoacetate in the rat Chemosphere. 14: 975-978. DOI: 10.1016/0045-6535(85)90228-0  1
1985 Kester JE, Gasiewicz TA. Rat liver Ah receptor: Chemical affectors of stability and TCDD binding Chemosphere. 14: 967-970. DOI: 10.1016/0045-6535(85)90226-7  1
1985 Schecter A, Gasiewicz TA, Eisen H, Schaffner F. Ultrastructural alterations in liver cells of humans, rats, and mouse hepatoma cells in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds Chemosphere. 14: 939-944. DOI: 10.1016/0045-6535(85)90220-6  1
1984 Gasiewicz TA, Rucci G. Examination and rapid analysis of hepatic cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using gel-permeation high performance liquid chromatography Bba - General Subjects. 798: 37-45. PMID 6322855 DOI: 10.1016/0304-4165(84)90007-2  1
1984 Gasiewicz TA, Ness WC, Rucci G. Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus Biochemical and Biophysical Research Communications. 118: 183-190. PMID 6320820 DOI: 10.1016/0006-291X(84)91084-2  1
1984 Gasiewicz TA, Rucci G. Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species Molecular Pharmacology. 26: 90-98. PMID 6087120  1
1984 Gasiewicz TA, Rucci G. Uptake and properties of receptors for 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) in hepatic nuclei from various mammalian species Federation Proceedings. 43: no. 2380.  1
1983 Gasiewicz TA, Geiger LE, Rucci G, Neal RA. Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice Drug Metabolism and Disposition. 11: 397-403. PMID 6138222  1
1982 Neal RA, Olson JR, Gasiewicz TA, Geiger LE. The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems Drug Metabolism Reviews. 13: 355-385. PMID 7049640 DOI: 10.3109/03602538209029985  1
1982 Gasiewicz TA, Neal RA. The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite Analytical Biochemistry. 124: 1-11. PMID 6289695 DOI: 10.1016/0003-2697(82)90212-3  1
1981 Swift LL, Gasiewicz TA, Dunn GD, Soulé PD, Neal RA. Characterization of the hyperlipidemia in guinea pigs induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicology and Applied Pharmacology. 59: 489-499. PMID 7268772 DOI: 10.1016/0041-008X(81)90302-1  1
1980 Olson JR, Gasiewicz TA, Neal RA. Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the golden Syrian hamster Toxicology and Applied Pharmacology. 56: 78-85. PMID 7444968 DOI: 10.1016/0041-008X(80)90132-5  1
1980 Gasiewicz TA, Holscher MA, Neal RA. The effect of total parenteral nutrition on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat Toxicology and Applied Pharmacology. 54: 469-488. PMID 6771887 DOI: 10.1016/0041-008X(80)90174-X  1
1979 Gasiewicz TA, Neal RA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs Toxicology and Applied Pharmacology. 51: 329-339. PMID 531895 DOI: 10.1016/0041-008X(79)90475-7  1
1979 Neal RA, Beatty PW, Gasiewicz TA. Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) Annals of the New York Academy of Sciences. 320: 204-213. PMID 222185 DOI: 10.1111/J.1749-6632.1979.Tb56602.X  1
1979 Gasiewicz TA, Holscher MA, Neal RA. The effect of total parenteral nutrition (TPN) on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the rat Federation Proceedings. 38: No.1624.  1
1978 Gasiewicz TA, Smith JC. Interaction between cadmium and selenium in rat plasma Environmental Health Perspectives. 133-136. PMID 720299 DOI: 10.1289/Ehp.7825133  1
1978 Gasiewicz TA, Smith JC. The metabolism of selenite by intact rat erythrocytes in vitro Chemico-Biological Interactions. 21: 299-313. PMID 679403 DOI: 10.1016/0009-2797(78)90028-5  1
1978 Gasiewicz TA, Smith JC. Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro Chemico-Biological Interactions. 23: 171-183. PMID 30541 DOI: 10.1016/0009-2797(78)90004-2  1
1978 Gasiewicz TA, Neal RA. Tissue distribution and excretion of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) and effects upon clinical chemical parameters in the guinea pig Federation Proceedings. 37: No. 1518.  1
1977 Gasiewicz TA, Smith JC. Similar properties of the cadmium (Cd) and selenium (Se) complex formed in rat plasma in vivo and in vitro Federation Proceedings. 36: No. 4658.  1
1976 Gasiewicz TA, Smith JC. Interactions of cadmium and selenium in rat plasma in vivo and in vitro Toxicology and Applied Pharmacology. 37: No. 156. DOI: 10.1016/0304-4165(76)90113-6  1
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