William G. Dunphy - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Cell Biology, Genetics, Biochemistry

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Ryu H, Yoshida MM, Sridharan V, Kumagai A, Dunphy WG, Dasso M, Azuma Y. SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin. Cell Cycle (Georgetown, Tex.). 14: 2777-84. PMID 26131587 DOI: 10.1080/15384101.2015.1066537  1
2015 Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Molecular Cell. 57: 492-505. PMID 25557548 DOI: 10.1016/j.molcel.2014.12.003  1
2013 Lee J, Dunphy WG. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Molecular Biology of the Cell. 24: 1343-53. PMID 23468519 DOI: 10.1091/mbc.E13-01-0025  1
2012 Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle (Georgetown, Tex.). 11: 1183-94. PMID 22391207 DOI: 10.4161/cc.11.6.19636  1
2011 Meng Z, Capalbo L, Glover DM, Dunphy WG. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Molecular Biology of the Cell. 22: 2834-47. PMID 21680713 DOI: 10.1091/mbc.E11-01-0048  1
2011 Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. The Journal of Cell Biology. 193: 995-1007. PMID 21646402 DOI: 10.1083/jcb.201102003  1
2011 Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG. CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. Cell Cycle (Georgetown, Tex.). 10: 469-80. PMID 21263215 DOI: 10.4161/cc.10.3.14711  1
2010 Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG, Campbell JL. Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle (Georgetown, Tex.). 9: 1156-66. PMID 20237432  1
2010 Gold DA, Dunphy WG. Drf1-dependent kinase interacts with Claspin through a conserved protein motif. The Journal of Biological Chemistry. 285: 12638-46. PMID 20190277 DOI: 10.1074/jbc.M109.077370  1
2010 Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell. 140: 349-59. PMID 20116089 DOI: 10.1016/j.cell.2009.12.049  1
2010 Lee J, Dunphy WG. Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks. Molecular Biology of the Cell. 21: 926-35. PMID 20110345 DOI: 10.1091/mbc.E09-11-0958  1
2009 Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Molecular Biology of the Cell. 20: 2351-60. PMID 19279141 DOI: 10.1091/mbc.E08-12-1190  1
2008 Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, et al. Aven-dependent activation of ATM following DNA damage. Current Biology : Cb. 18: 933-42. PMID 18571408 DOI: 10.1016/j.cub.2008.05.045  1
2007 Lee J, Kumagai A, Dunphy WG. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. The Journal of Biological Chemistry. 282: 28036-44. PMID 17636252 DOI: 10.1074/jbc.M704635200  1
2007 Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. The Journal of Biological Chemistry. 282: 17501-6. PMID 17446169 DOI: 10.1074/jbc.M701770200  1
2006 Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 127: 759-73. PMID 17110335 DOI: 10.1016/j.cell.2006.10.035  1
2006 Kumagai A, Dunphy WG. How cells activate ATR. Cell Cycle (Georgetown, Tex.). 5: 1265-8. PMID 16760665  1
2006 Yoo HY, Jeong SY, Dunphy WG. Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures. Genes & Development. 20: 772-83. PMID 16547171 DOI: 10.1101/gad.1398806  1
2006 Kumagai A, Lee J, Yoo HY, Dunphy WG. TopBP1 activates the ATR-ATRIP complex. Cell. 124: 943-55. PMID 16530042 DOI: 10.1016/j.cell.2005.12.041  1
2005 Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell. 123: 89-103. PMID 16213215 DOI: 10.1016/j.cell.2005.07.032  1
2005 Kim SM, Kumagai A, Lee J, Dunphy WG. Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. The Journal of Biological Chemistry. 280: 38355-64. PMID 16186122 DOI: 10.1074/jbc.M508673200  1
2005 Lee J, Gold DA, Shevchenko A, Shevchenko A, Dunphy WG. Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response. Molecular Biology of the Cell. 16: 5269-82. PMID 16148040 DOI: 10.1091/mbc.E05-07-0671  1
2005 Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell. 121: 887-98. PMID 15960976 DOI: 10.1016/j.cell.2005.05.015  1
2004 Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. The Journal of Biological Chemistry. 279: 53353-64. PMID 15448142 DOI: 10.1074/jbc.M408026200  1
2004 Kumagai A, Kim SM, Dunphy WG. Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. The Journal of Biological Chemistry. 279: 49599-608. PMID 15371427 DOI: 10.1074/jbc.M408353200  1
2004 Li W, Kim SM, Lee J, Dunphy WG. Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases. The Journal of Cell Biology. 165: 801-12. PMID 15197177 DOI: 10.1083/jcb.200402095  1
2004 Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell. 117: 575-88. PMID 15163406 DOI: 10.1016/S0092-8674(04)00417-9  1
2003 Jeong SY, Kumagai A, Lee J, Dunphy WG. Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation. The Journal of Biological Chemistry. 278: 46782-8. PMID 12963733 DOI: 10.1074/jbc.M304551200  1
2003 Yanow SK, Gold DA, Yoo HY, Dunphy WG. Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest. The Journal of Biological Chemistry. 278: 41083-92. PMID 12897072 DOI: 10.1074/jbc.M307144200  1
2003 Lee J, Kumagai A, Dunphy WG. Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17. Molecular Cell. 11: 329-40. PMID 12620222 DOI: 10.1016/S1097-2765(03)00045-5  1
2003 Kumagai A, Dunphy WG. Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1. Nature Cell Biology. 5: 161-5. PMID 12545175 DOI: 10.1038/ncb921  1
2003 Dunphy WG. Properties of the Cdc25 Family of Cell-Cycle Regulatory Phosphatases Handbook of Cell Signaling. 1: 693-696. DOI: 10.1016/B978-012124546-7/50476-9  1
2002 Sheng J, Kumagai A, Dunphy WG, Varshavsky A. Dissection of c-MOS degron. The Embo Journal. 21: 6061-71. PMID 12426378 DOI: 10.1093/emboj/cdf626  1
2001 Budde PP, Kumagai A, Dunphy WG, Heald R. Regulation of Op18 during spindle assembly in Xenopus egg extracts. The Journal of Cell Biology. 153: 149-58. PMID 11285281 DOI: 10.1083/jcb.153.1.149  1
2001 Lee J, Kumagai A, Dunphy WG. Positive regulation of Wee1 by Chk1 and 14-3-3 proteins Molecular Biology of the Cell. 12: 551-563. PMID 11251070  1
2001 Xia Z, Morales JC, Dunphy WG, Carpenter PB. Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1 Journal of Biological Chemistry. 276: 2708-2718. PMID 11042216 DOI: 10.1074/jbc.M007665200  1
2000 Wang SX, Dunphy WG. Activation of Xenopus Chk1 by mutagenesis of threonine-377 Febs Letters. 487: 277-281. PMID 11150524 DOI: 10.1016/S0014-5793(00)02370-X  1
2000 Kumagai A, Dunphy WG. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts Molecular Cell. 6: 839-849. PMID 11090622  1
2000 Guo Z, Kumagai A, Wang SX, Dunphy WG. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts Genes and Development. 14: 2745-2756. PMID 11069891 DOI: 10.1101/gad.842500  1
2000 Zijian G, Dunphy WG. Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends Molecular Biology of the Cell. 11: 1535-1546. PMID 10793133  1
1999 Patra D, Wang SX, Kumagai A, Dunphy WG. The xenopus Suc1/Cks protein promotes the phosphorylation of G(2)/M regulators. The Journal of Biological Chemistry. 274: 36839-42. PMID 10601234 DOI: 10.1074/jbc.274.52.36839  1
1999 Kumagai A, Dunphy WG. Binding of 14-3-3 proteins and nuclear export control the mtracellular localization of the mitotic inducer Cdc25 Genes and Development. 13: 1067-1072. PMID 10323858  1
1998 Kumagai A, Guo Z, Emami KH, Wang SX, Dunphy WG. The Xenopus Chk1 protein kinase mediates caffeine-sensitive pathway of checkpoint control in cell-free extracts Journal of Cell Biology. 142: 1559-1569. PMID 9744884 DOI: 10.1083/jcb.142.6.1559  1
1998 Carpenter PB, Dunphy WG. Identification of a novel 81-kDa component of the Xenopus origin recognition complex Journal of Biological Chemistry. 273: 24891-24897. PMID 9733795 DOI: 10.1074/jbc.273.38.24891  1
1998 Patra D, Dunphy WG. Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis. Genes & Development. 12: 2549-59. PMID 9716407  1
1998 Kumagai A, Yakowec PS, Dunphy WG. 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts Molecular Biology of the Cell. 9: 345-354. PMID 9450960  1
1997 Kumagai A, Dunphy WG. Regulation of Xenopus Cdc25 protein Methods in Enzymology. 283: 564-571. PMID 9251048 DOI: 10.1016/S0076-6879(97)83044-3  1
1996 Shou W, Dunphy WG. Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases Molecular Biology of the Cell. 7: 457-469. PMID 8868473  1
1996 Coleman TR, Carpenter PB, Dunphy WG. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts Cell. 87: 53-63. PMID 8858148 DOI: 10.1016/S0092-8674(00)81322-7  1
1996 Kumagai A, Dunphy WG. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts Science. 273: 1377-1380. PMID 8703070  1
1996 Patra D, Dunphy WG. Xe-p9, a Xenopus Suc1/Cks homolog, has multiple essential roles in cell cycle control. Genes & Development. 10: 1503-15. PMID 8666234  1
1996 Carpenter PB, Mueller PR, Dunphy WG. Role for a Xenopus Orc2-related protein in controlling DNA replication Nature. 379: 357-360. PMID 8552193 DOI: 10.1038/379357a0  1
1995 Kumagai A, Dunphy WG. Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors Molecular Biology of the Cell. 6: 199-213. PMID 7787246  1
1995 Mueller PR, Coleman TR, Dunphy WG. Cell cycle regulation of a Xenopus weel-like kinase Molecular Biology of the Cell. 6: 119-134. PMID 7749193  1
1995 Mueller PR, Coleman TR, Kumagai A, Dunphy WG. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15 Science. 270: 86-90. PMID 7569953  1
1994 Coleman TR, Dunphy WG. Cdc2 regulatory factors Current Opinion in Cell Biology. 6: 877-882. PMID 7880537 DOI: 10.1016/0955-0674(94)90060-4  1
1993 Coleman TR, Tang Z, Dunphy WG. Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer Cell. 72: 919-929. PMID 7681363 DOI: 10.1016/0092-8674(93)90580-J  1
1993 Tang Z, Coleman TR, Dunphy WG. Two distinct mechanisms for negative regulation of the Wee 1 protein kinase Embo Journal. 12: 3427-3436. PMID 7504624  1
1992 Kumagai A, Dunphy WG. Regulation of the cdc25 protein during the cell cycle in Xenopus extracts Cell. 70: 139-151. PMID 1623517 DOI: 10.1016/0092-8674(92)90540-S  1
1991 Milarski KL, Dunphy WG, Russell P, Gould SJ, Newport JW. Cloning and characterization of Xenopus cdc2, a component of MPF. Cold Spring Harbor Symposia On Quantitative Biology. 56: 377-84. PMID 1840255  1
1991 Kumagai A, Dunphy WG. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system Cell. 64: 903-914. PMID 1825803  1
1991 Kumagai A, Dunphy WG. Molecular mechanism of the final steps in the activation of MPF Cold Spring Harbor Symposia On Quantitative Biology. 56: 585-589. PMID 1819508  1
1991 Dunphy WG, Kumagai A. The cdc25 protein contains an intrinsic phosphatase activity Cell. 67: 189-196. PMID 1655274  1
1990 Newport JW, Wilson KL, Dunphy WG. A lamin-independent pathway for nuclear envelope assembly. The Journal of Cell Biology. 111: 2247-59. PMID 2277059  1
1989 Dunphy WG, Newport JW. Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. Cell. 58: 181-91. PMID 2473838 DOI: 10.1016/0092-8674(89)90414-5  1
1988 Dunphy WG, Brizuela L, Beach D, Newport J. The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell. 54: 423-31. PMID 3293802 DOI: 10.1016/0092-8674(88)90205-X  1
1988 Dunphy WG, Newport JW. Mitosis-inducing factors are present in a latent form during interphase in the Xenopus embryo. The Journal of Cell Biology. 106: 2047-56. PMID 3290226  1
1988 Dunphy WG, Newport JW. Unraveling of mitotic control mechanisms. Cell. 55: 925-8. PMID 3060263  1
1986 Dunphy WG, Pfeffer SR, Clary DO, Wattenberg BW, Glick BS, Rothman JE. Yeast and mammals utilize similar cytosolic components to drive protein transport through the Golgi complex. Proceedings of the National Academy of Sciences of the United States of America. 83: 1622-6. PMID 3513182  1
1985 Dunphy WG, Rothman JE. Compartmental organization of the golgi stack Cell. 42: 13-21. PMID 3926324 DOI: 10.1016/S0092-8674(85)80097-0  1
1985 Dunphy WG, Brands R, Rothman JE. Attachment of terminal N-acetylglucosamine to asparagine-linked oligosaccharides occurs in central cisternae of the golgi stack Cell. 40: 463-472. PMID 3155653 DOI: 10.1016/0092-8674(85)90161-8  1
1984 Balch WE, Dunphy WG, Braell WA, Rothman JE. Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine. Cell. 39: 405-16. PMID 6498939 DOI: 10.1016/0092-8674(84)90019-9  1
1983 Dunphy WG, Rothman JE. Compartmentation of asparagine-linked oligosaccharide processing in the Golgi apparatus Journal of Cell Biology. 97: 270-275. PMID 6223041  1
1982 Blumberg PM, Delclos KB, Dunphy WG, Jaken S. Specific binding of phorbol ester tumor promoters to mouse tissues and cultured cells Carcinogenesis; a Comprehensive Survey. 7: 519-535. PMID 7039833  1
1982 Rothman JE, Fries E, Dunphy WG, Urbani LJ. The Golgi apparatus, coated vesicles, and the sorting problem Cold Spring Harbor Symposia On Quantitative Biology. 46: 797-805. PMID 6955107  1
1981 Dunphy WG, Kochenburger RJ, Blumberg PM, Castagna M. Kinetics and Subcellular Localization of Specific [3H]Phorbol 12,13-Dibutyrate Binding by Mouse Brain Cancer Research. 41: 2640-2647. PMID 6941848  1
1981 Dunphy WG, Fries E, Urbani LJ, Rothman JE. Early and late functions associated with the Golgi apparatus reside in distinct compartments Proceedings of the National Academy of Sciences of the United States of America. 78: 7453-7457. PMID 6801652  1
1981 Blumberg PM, Delclos KB, Dunphy WG. Phorbol ester binding to mouse brain Proceedings of the American Association For Cancer Research. 503.  1
1980 Dunphy WG, Delclos KB, Blumberg PM. Characterization of Specific Binding of [3H]Phorbol 12,13-Dibutyrate and [3H]Phorbol 12-Myristate 13-Acetate to Mouse Brain Cancer Research. 40: 3635-3641. PMID 7438048  1
1980 Dunphy WG, Lau CC, Blumberg PM. Phorbol related diterpene esters have similar structure-activity relations in swiss 3t3 cells and chicken embryo fibroblasts Carcinogenesis. 1: 347-351. PMID 7273274 DOI: 10.1093/carcin/1.4.347  1
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