James C. Sacchettini - Publications

Texas A & M University, College Station, TX, United States 

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Guardia A, Gulten G, Fernandez R, Gómez J, Wang F, Convery M, Blanco D, Martínez M, Pérez-Herrán E, Alonso M, Ortega F, Rullás J, Calvo D, Mata L, Young R, ... Sacchettini JC, et al. N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity. Chemmedchem. PMID 26934341 DOI: 10.1002/cmdc.201600020  0.56
2016 Bageshwar UK, VerPlank L, Baker D, Dong W, Hamsanathan S, Whitaker N, Sacchettini JC, Musser SM. High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors. Plos One. 11: e0149659. PMID 26901445 DOI: 10.1371/journal.pone.0149659  0.56
2016 Cheng YS, Sacchettini JC. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry. PMID 26848874 DOI: 10.1021/acs.biochem.5b00993  0.56
2015 Swanson S, Ioerger TR, Rigel NW, Miller BK, Braunstein M, Sacchettini JC. Structural similarities and differences between two functionally distinct SecA proteins: the Mycobacterium tuberculosis SecA1 and SecA2. Journal of Bacteriology. PMID 26668263 DOI: 10.1128/JB.00696-15  0.56
2015 Hong W, Wang Y, Chang Z, Yang Y, Pu J, Sun T, Kaur S, Sacchettini JC, Jung H, Lin Wong W, Fah Yap L, Fong Ngeow Y, Paterson IC, Wang H. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling. Scientific Reports. 5: 15328. PMID 26471125 DOI: 10.1038/srep15328  0.56
2015 Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 112: 13087-92. PMID 26438867 DOI: 10.1073/pnas.1514135112  0.56
2015 Li X, Sun Q, Jiang C, Yang K, Hung LW, Zhang J, Sacchettini JC. Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. Structure (London, England : 1993). PMID 26299947 DOI: 10.1016/j.str.2015.07.014  0.56
2015 Loesch K, Galaviz S, Hamoui Z, Clanton R, Akabani G, Deveau M, DeJesus M, Ioerger T, Sacchettini JC, Wallis D. Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes. Plos One. 10: e0120534. PMID 25853515 DOI: 10.1371/journal.pone.0120534  0.56
2015 Kanetaka H, Koseki Y, Taira J, Umei T, Komatsu H, Sakamoto H, Gulten G, Sacchettini JC, Kitamura M, Aoki S. Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach. European Journal of Medicinal Chemistry. 94: 378-85. PMID 25778993 DOI: 10.1016/j.ejmech.2015.02.062  0.56
2015 Wallis D, Loesch K, Galaviz S, Sun Q, DeJesus M, Ioerger T, Sacchettini JC. High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection. Stem Cells (Dayton, Ohio). 33: 2509-22. PMID 25752821 DOI: 10.1002/stem.1983  0.56
2015 Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrobial Agents and Chemotherapy. 59: 2256-64. PMID 25645825 DOI: 10.1128/AAC.05114-14  0.56
2014 Reddy MC, Breda A, Bruning JB, Sherekar M, Valluru S, Thurman C, Ehrenfeld H, Sacchettini JC. Structure, activity, and inhibition of the Carboxyltransferase β-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 58: 6122-32. PMID 25092705 DOI: 10.1128/AAC.02574-13  0.56
2014 Nixon MR, Saionz KW, Koo MS, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T, Sacchettini JC, Rhee KY, Freundlich JS, Sherman DR. Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis. Chemistry & Biology. 21: 819-30. PMID 24954008 DOI: 10.1016/j.chembiol.2014.04.009  0.56
2014 Shi X, Festa RA, Ioerger TR, Butler-Wu S, Sacchettini JC, Darwin KH, Samanovic MI. The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence. Mbio. 5. PMID 24549843 DOI: 10.1128/mBio.00876-13  0.56
2013 Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 155: 1296-308. PMID 24315099 DOI: 10.1016/j.cell.2013.10.045  0.56
2013 Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. Plos One. 8: e77844. PMID 24265677 DOI: 10.1371/journal.pone.0077844  0.56
2013 Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. Plos One. 8: e75245. PMID 24086479 DOI: 10.1371/journal.pone.0075245  0.56
2013 Gulten G, Sacchettini JC. Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD. Structure (London, England : 1993). 21: 1859-69. PMID 24055315 DOI: 10.1016/j.str.2013.08.014  0.56
2013 Small JL, Park SW, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis. Mbio. 4: e00475-13. PMID 24045640 DOI: 10.1128/mBio.00475-13  0.56
2013 Lanzas F, Karakousis PC, Sacchettini JC, Ioerger TR. Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa. Journal of Clinical Microbiology. 51: 3277-85. PMID 23884993 DOI: 10.1128/JCM.01122-13  0.56
2013 Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD. Redefining the role of the quaternary shift in Bacillus stearothermophilus phosphofructokinase. Biochemistry. 52: 5421-9. PMID 23859543 DOI: 10.1021/bi4002503  0.56
2013 Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proceedings of the National Academy of Sciences of the United States of America. 110: 11565-70. PMID 23798446 DOI: 10.1073/pnas.1302114110  0.56
2013 Liu Z, Ioerger TR, Wang F, Sacchettini JC. Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. The Journal of Biological Chemistry. 288: 18473-83. PMID 23625916 DOI: 10.1074/jbc.M113.466912  0.56
2013 Gokulan K, O'Leary SE, Russell WK, Russell DH, Lalgondar M, Begley TP, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. The Journal of Biological Chemistry. 288: 16484-94. PMID 23615910 DOI: 10.1074/jbc.M113.468892  0.56
2013 Kinjo T, Koseki Y, Kobayashi M, Yamada A, Morita K, Yamaguchi K, Tsurusawa R, Gulten G, Komatsu H, Sakamoto H, Sacchettini JC, Kitamura M, Aoki S. Identification of compounds with potential antibacterial activity against Mycobacterium through structure-based drug screening. Journal of Chemical Information and Modeling. 53: 1200-12. PMID 23600706 DOI: 10.1021/ci300571n  0.56
2013 Gopinath K, Venclovas C, Ioerger TR, Sacchettini JC, McKinney JD, Mizrahi V, Warner DF. A vitamin B₁₂ transporter in Mycobacterium tuberculosis. Open Biology. 3: 120175. PMID 23407640 DOI: 10.1098/rsob.120175  0.56
2013 DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics (Oxford, England). 29: 695-703. PMID 23361328 DOI: 10.1093/bioinformatics/btt043  0.56
2013 Anderson JW, Sarantakis D, Terpinski J, Kumar TR, Tsai HC, Kuo M, Ager AL, Jacobs WR, Schiehser GA, Ekins S, Sacchettini JC, Jacobus DP, Fidock DA, Freundlich JS. Novel diaryl ureas with efficacy in a mouse model of malaria. Bioorganic & Medicinal Chemistry Letters. 23: 1022-5. PMID 23313245 DOI: 10.1016/j.bmcl.2012.12.022  0.56
2013 DeJesus MA, Sacchettini JC, Ioerger TR. Reannotation of translational start sites in the genome of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 93: 18-25. PMID 23273318 DOI: 10.1016/j.tube.2012.11.012  0.56
2012 Krieger IV, Freundlich JS, Gawandi VB, Roberts JP, Gawandi VB, Sun Q, Owen JL, Fraile MT, Huss SI, Lavandera JL, Ioerger TR, Sacchettini JC. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chemistry & Biology. 19: 1556-67. PMID 23261599 DOI: 10.1016/j.chembiol.2012.09.018  0.56
2012 Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. Plos Pathogens. 8: e1002946. PMID 23028335 DOI: 10.1371/journal.ppat.1002946  0.56
2012 Xie H, Mire J, Kong Y, Chang M, Hassounah HA, Thornton CN, Sacchettini JC, Cirillo JD, Rao J. Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe. Nature Chemistry. 4: 802-9. PMID 23000993 DOI: 10.1038/nchem.1435  0.56
2012 James JN, Hasan ZU, Ioerger TR, Brown AC, Personne Y, Carroll P, Ikeh M, Tilston-Lunel NL, Palavecino C, Sacchettini JC, Parish T. Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions. Microbiology (Reading, England). 158: 2724-31. PMID 22956756 DOI: 10.1099/mic.0.060319-0  0.56
2012 Chia BS, Lanzas F, Rifat D, Herrera A, Kim EY, Sailer C, Torres-Chavolla E, Narayanaswamy P, Einarsson V, Bravo J, Pascale JM, Ioerger TR, Sacchettini JC, Karakousis PC. Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama. Plos One. 7: e40456. PMID 22792333 DOI: 10.1371/journal.pone.0040456  0.56
2012 Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Science : a Publication of the Protein Society. 21: 571-82. PMID 22389108 DOI: 10.1002/pro.2042  0.56
2012 Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD. Structure of the apo form of Bacillus stearothermophilus phosphofructokinase. Biochemistry. 51: 769-75. PMID 22212099 DOI: 10.1021/bi201548p  0.56
2012 La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrobial Agents and Chemotherapy. 56: 324-31. PMID 22024828 DOI: 10.1128/AAC.05270-11  0.56
2011 Madina BR, Kuppan G, Vashisht AA, Liang YH, Downey KM, Wohlschlegel JA, Ji X, Sze SH, Sacchettini JC, Read LK, Cruz-Reyes J. Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei. Rna (New York, N.Y.). 17: 1821-30. PMID 21810935 DOI: 10.1261/rna.2815911  0.56
2011 Gokulan K, Aggarwal A, Shipman L, Besra GS, Sacchettini JC. Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. Acta Crystallographica. Section D, Biological Crystallography. 67: 657-69. PMID 21697604 DOI: 10.1107/S0907444911020221  0.56
2011 Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR. Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions. Antimicrobial Agents and Chemotherapy. 55: 3889-98. PMID 21628538 DOI: 10.1128/AAC.00266-11  0.56
2011 Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature Genetics. 43: 482-6. PMID 21516081 DOI: 10.1038/ng.811  0.56
2011 Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/BJ20110002  0.56
2011 Arockiasamy A, Aggarwal A, Savva CG, Holzenburg A, Sacchettini JC. Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site. Protein Science : a Publication of the Protein Society. 20: 827-33. PMID 21370306 DOI: 10.1002/pro.607  0.56
2011 Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, ... ... Sacchettini JC, et al. The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinburgh, Scotland). 91: 155-72. PMID 21247804 DOI: 10.1016/j.tube.2010.11.009  0.56
2011 Bruning JB, Murillo AC, Chacon O, Barletta RG, Sacchettini JC. Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine. Antimicrobial Agents and Chemotherapy. 55: 291-301. PMID 20956591 DOI: 10.1128/AAC.00558-10  0.56
2011 Lotesta SD, Liu J, Yates EV, Krieger I, Sacchettini JC, Freundlich JS, Sorensen EJ. Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis Chemical Science. 2: 1258-1261. DOI: 10.1039/c1sc00116g  0.56
2010 Molle V, Gulten G, Vilchèze C, Veyron-Churlet R, Zanella-Cléon I, Sacchettini JC, Jacobs WR, Kremer L. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Molecular Microbiology. 78: 1591-605. PMID 21143326 DOI: 10.1111/j.1365-2958.2010.07446.x  0.56
2010 Ioerger TR, Feng Y, Chen X, Dobos KM, Victor TC, Streicher EM, Warren RM, Gey van Pittius NC, Van Helden PD, Sacchettini JC. The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa. Bmc Genomics. 11: 670. PMID 21110864 DOI: 10.1186/1471-2164-11-670  0.56
2010 Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC. The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 90: 298-300. PMID 20739223 DOI: 10.1016/j.tube.2010.08.002  0.56
2010 Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nature Structural & Molecular Biology. 17: 1088-95. PMID 20694006 DOI: 10.1038/nsmb.1869  0.56
2010 Kong Y, Yao H, Ren H, Subbian S, Cirillo SL, Sacchettini JC, Rao J, Cirillo JD. Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 12239-44. PMID 20566877 DOI: 10.1073/pnas.1000643107  0.56
2010 Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilchèze C, Jacobs WR, Sacchettini JC. Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid. Antimicrobial Agents and Chemotherapy. 54: 3776-82. PMID 20566771 DOI: 10.1128/AAC.00453-10  0.56
2010 Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 49: 6746-60. PMID 20565114 DOI: 10.1021/bi902097j  0.56
2010 Shetty ND, Reddy MC, Palaninathan SK, Owen JL, Sacchettini JC. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Science : a Publication of the Protein Society. 19: 1513-24. PMID 20521335 DOI: 10.1002/pro.430  0.56
2010 Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. Journal of Bacteriology. 192: 3645-53. PMID 20472797 DOI: 10.1128/JB.00166-10  0.56
2010 Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nature Chemical Biology. 6: 376-84. PMID 20305657 DOI: 10.1038/nchembio.340  0.56
2010 Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini JC, Stoker NG, Kaplan G, Mizrahi V. Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis. Journal of Bacteriology. 192: 2220-7. PMID 20139184 DOI: 10.1128/JB.01135-09  0.56
2009 Musa TL, Ioerger TR, Sacchettini JC. The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery. Advances in Protein Chemistry and Structural Biology. 77: 41-76. PMID 20663481 DOI: 10.1016/S1876-1623(09)77003-8  0.56
2009 Ioerger TR, Koo S, No EG, Chen X, Larsen MH, Jacobs WR, Pillay M, Sturm AW, Sacchettini JC. Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. Plos One. 4: e7778. PMID 19890396 DOI: 10.1371/journal.pone.0007778  0.56
2009 Sun Q, Kuty GF, Arockiasamy A, Xu M, Young R, Sacchettini JC. Regulation of a muralytic enzyme by dynamic membrane topology. Nature Structural & Molecular Biology. 16: 1192-4. PMID 19881499 DOI: 10.1038/nsmb.1681  0.56
2009 Reddy MC, Palaninathan SK, Bruning JB, Thurman C, Smith D, Sacchettini JC. Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein. The Journal of Biological Chemistry. 284: 36581-91. PMID 19740754 DOI: 10.1074/jbc.M109.041343  0.56
2009 Palaninathan SK, Mohamedmohaideen NN, Orlandini E, Ortore G, Nencetti S, Lapucci A, Rossello A, Freundlich JS, Sacchettini JC. Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. Plos One. 4: e6290. PMID 19621084 DOI: 10.1371/journal.pone.0006290  0.56
2009 Swanson S, Gokulan K, Sacchettini JC. KasA, another brick in the mycobacterial cell wall. Structure (London, England : 1993). 17: 914-5. PMID 19604470 DOI: 10.1016/j.str.2009.06.006  0.56
2009 Ioerger TR, Sacchettini JC. Structural genomics approach to drug discovery for Mycobacterium tuberculosis. Current Opinion in Microbiology. 12: 318-25. PMID 19481971 DOI: 10.1016/j.mib.2009.04.006  0.56
2009 Barkan D, Liu Z, Sacchettini JC, Glickman MS. Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chemistry & Biology. 16: 499-509. PMID 19477414 DOI: 10.1016/j.chembiol.2009.04.001  0.56
2009 Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR, Sacchettini JC. Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis. Chemmedchem. 4: 241-8. PMID 19130456 DOI: 10.1002/cmdc.200800261  0.56
2008 Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, ... ... Sacchettini JC, et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host & Microbe. 4: 567-78. PMID 19064257 DOI: 10.1016/j.chom.2008.11.001  0.56
2008 Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC. Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Science : a Publication of the Protein Society. 17: 2134-44. PMID 18815415 DOI: 10.1110/ps.038125.108  0.56
2008 Cho Y, Ioerger TR, Sacchettini JC. Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. Journal of Medicinal Chemistry. 51: 5984-92. PMID 18778048 DOI: 10.1021/jm800328v  0.56
2008 Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. Journal of Molecular Biology. 382: 1157-67. PMID 18662699 DOI: 10.1016/j.jmb.2008.07.029  0.56
2008 Vilchèze C, Av-Gay Y, Attarian R, Liu Z, Hazbón MH, Colangeli R, Chen B, Liu W, Alland D, Sacchettini JC, Jacobs WR. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Molecular Microbiology. 69: 1316-29. PMID 18651841 DOI: 10.1111/j.1365-2958.2008.06365.x  0.56
2008 Dey S, Burton RL, Grant GA, Sacchettini JC. Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase. Biochemistry. 47: 8271-82. PMID 18627175 DOI: 10.1021/bi800212b  0.56
2008 Javid-Majd F, Yang D, Ioerger TR, Sacchettini JC. The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Acta Crystallographica. Section D, Biological Crystallography. 64: 627-35. PMID 18560150 DOI: 10.1107/S0907444908007105  0.56
2008 Zwart PH, Afonine PV, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, McKee E, Moriarty NW, Read RJ, Sacchettini JC, Sauter NK, Storoni LC, Terwilliger TC, Adams PD. Automated structure solution with the PHENIX suite. Methods in Molecular Biology (Clifton, N.J.). 426: 419-35. PMID 18542881 DOI: 10.1007/978-1-60327-058-8_28  0.56
2008 Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR, Sacchettini JC. Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry. 47: 6092-102. PMID 18479146 DOI: 10.1021/bi701929m  0.56
2008 Chinnaswamy S, Yarbrough I, Palaninathan S, Kumar CT, Vijayaraghavan V, Demeler B, Lemon SM, Sacchettini JC, Kao CC. A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. The Journal of Biological Chemistry. 283: 20535-46. PMID 18442978 DOI: 10.1074/jbc.M801490200  0.56
2008 Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nature Reviews. Microbiology. 6: 41-52. PMID 18079742 DOI: 10.1038/nrmicro1816  0.56
2008 Bhardwaj K, Palaninathan S, Alcantara JM, Yi LL, Guarino L, Sacchettini JC, Kao CC. Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. The Journal of Biological Chemistry. 283: 3655-64. PMID 18045871 DOI: 10.1074/jbc.M708375200  0.56
2008 Reddy MC, Gokulan K, Jacobs WR, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Science : a Publication of the Protein Society. 17: 159-70. PMID 18042675 DOI: 10.1110/ps.073192208  0.56
2008 Giddens AC, Nielsen L, Boshoff HI, Tasdemir D, Perozzo R, Kaiser M, Wang F, Sacchettini JC, Copp BR. Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities Tetrahedron. 64: 1242-1249. DOI: 10.1016/j.tet.2007.11.075  0.56
2008 Pai R, Sacchettini JC, Ioerger TR. Specificity normalization for identifying selective inhibitors in virtual screening Proceedings of the 2008 International Conference On Bioinformatics and Computational Biology, Biocomp 2008. 787-793.  0.56
2008 Pai R, Sacchettini JC, Ioerger TR. Analysis of protein-ligand interactions using localized stereochemical features Proceedings of the 2008 International Conference On Bioinformatics and Computational Biology, Biocomp 2008. 666-673.  0.56
2007 Alahari A, Trivelli X, Guérardel Y, Dover LG, Besra GS, Sacchettini JC, Reynolds RC, Coxon GD, Kremer L. Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. Plos One. 2: e1343. PMID 18094751 DOI: 10.1371/journal.pone.0001343  0.56
2007 Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, ... ... Sacchettini JC, et al. High throughput crystallography of TB drug targets. Infectious Disorders Drug Targets. 7: 127-39. PMID 17970224 DOI: 10.2174/187152607781001853  0.56
2007 Reddy MC, Palaninathan SK, Shetty ND, Owen JL, Watson MD, Sacchettini JC. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. The Journal of Biological Chemistry. 282: 27334-42. PMID 17597075 DOI: 10.1074/jbc.M703290200  0.56
2007 Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR, Schiehser GA, Jacobus DP, Fidock DA, ... Sacchettini JC, et al. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. The Journal of Biological Chemistry. 282: 25436-44. PMID 17567585 DOI: 10.1074/jbc.M701813200  0.56
2007 Tsai CL, Gokulan K, Sobrado P, Sacchettini JC, Fitzpatrick PF. Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Biochemistry. 46: 7844-51. PMID 17563122 DOI: 10.1021/bi7005543  0.56
2007 Cai X, Lorraine Fuller A, McDougald LR, Tan X, Cai J, Wang F, Sacchettini JC, Zhu G. Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa). Fems Microbiology Letters. 272: 238-44. PMID 17559403 DOI: 10.1111/j.1574-6968.2007.00767.x  0.56
2007 Wang F, Langley R, Gulten G, Wang L, Sacchettini JC. Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence. Chemistry & Biology. 14: 543-51. PMID 17524985 DOI: 10.1016/j.chembiol.2007.04.005  0.56
2007 Nicola G, Smith CA, Lucumi E, Kuo MR, Karagyozov L, Fidock DA, Sacchettini JC, Abagyan R. Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening. Biochemical and Biophysical Research Communications. 358: 686-91. PMID 17509532 DOI: 10.1016/j.bbrc.2007.04.113  0.56
2007 Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA. The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase. The Journal of Biological Chemistry. 282: 18418-26. PMID 17459882 DOI: 10.1074/jbc.M701174200  0.56
2007 Ramesh A, Savva CG, Holzenburg A, Sacchettini JC. Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity. The Journal of Biological Chemistry. 282: 14960-7. PMID 17392270 DOI: 10.1074/jbc.M611163200  0.56
2007 Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. The Journal of Experimental Medicine. 204: 73-8. PMID 17227913 DOI: 10.1084/jem.20062100  0.56
2007 Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC. X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). Journal of Molecular Biology. 366: 469-80. PMID 17174327 DOI: 10.1016/j.jmb.2006.11.006  0.56
2007 Liu T, Ramesh A, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP. CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. Nature Chemical Biology. 3: 60-8. PMID 17143269 DOI: 10.1038/nchembio844  0.56
2007 Sidhu AB, Sun Q, Nkrumah LJ, Dunne MW, Sacchettini JC, Fidock DA. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. The Journal of Biological Chemistry. 282: 2494-504. PMID 17110371 DOI: 10.1074/jbc.M608615200  0.56
2007 Gopal K, Sacchettini JC, Joerger TR. Database approaches and data representation in structural bioinformatics Proceedings of the 7th Ieee International Conference On Bioinformatics and Bioengineering, Bibe. 425-432. DOI: 10.1109/BIBE.2007.4375597  0.56
2006 Romo TD, Sacchettini JC, Ioerger TR. Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building. Acta Crystallographica. Section D, Biological Crystallography. 62: 1401-6. PMID 17057345 DOI: 10.1107/S0907444906034019  0.56
2006 Owens RM, Hsu FF, VanderVen BC, Purdy GE, Hesteande E, Giannakas P, Sacchettini JC, McKinney JD, Hill PJ, Belisle JT, Butcher BA, Pethe K, Russell DG. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Molecular Microbiology. 60: 1152-63. PMID 16689792 DOI: 10.1111/j.1365-2958.2006.05174.x  0.56
2006 Gaffin RD, Gokulan K, Sacchettini JC, Hewett TE, Klevitsky R, Robbins J, Sarin V, Zawieja DC, Meininger GA, Muthuchamy M. Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. American Journal of Physiology. Heart and Circulatory Physiology. 291: H552-63. PMID 16501024 DOI: 10.1152/ajpheart.00688.2005  0.56
2006 Freundlich JS, Yu M, Lucumi E, Kuo M, Tsai HC, Valderramos JC, Karagyozov L, Jacobs WR, Schiehser GA, Fidock DA, Jacobus DP, Sacchettini JC. Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 16: 2163-9. PMID 16466916 DOI: 10.1016/j.bmcl.2006.01.051  0.56
2005 Trevino SR, Gokulan K, Newsom S, Thurlkill RL, Shaw KL, Mitkevich VA, Makarov AA, Sacchettini JC, Scholtz JM, Pace CN. Asp79 makes a large, unfavorable contribution to the stability of RNase Sa. Journal of Molecular Biology. 354: 967-78. PMID 16288913 DOI: 10.1016/j.jmb.2005.09.091  0.56
2005 Paricharttanakul NM, Ye S, Menefee AL, Javid-Majd F, Sacchettini JC, Reinhart GD. Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus. Biochemistry. 44: 15280-6. PMID 16285731 DOI: 10.1021/bi051283g  0.56
2005 Gokulan K, Khare S, Ronning DR, Linthicum SD, Sacchettini JC, Rupp B. Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners. Biochemistry. 44: 9889-98. PMID 16026161 DOI: 10.1021/bi050613u  0.48
2005 Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA. D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. The Journal of Biological Chemistry. 280: 14884-91. PMID 15668250 DOI: 10.1074/jbc.M414488200  0.48
2005 Dey S, Grant GA, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits. The Journal of Biological Chemistry. 280: 14892-9. PMID 15668249 DOI: 10.1074/jbc.M414489200  0.48
2004 Gopal K, Romo TD, Sacchettini JC, Ioerger TR. Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography. Proceedings / Ieee Computational Systems Bioinformatics Conference, Csb. Ieee Computational Systems Bioinformatics Conference. 255-65. PMID 16448019  0.56
2004 Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. The Journal of Biological Chemistry. 279: 36771-7. PMID 15192106 DOI: 10.1074/jbc.M400811200  0.56
2003 Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs WR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proceedings of the National Academy of Sciences of the United States of America. 100: 2243-8. PMID 12606717 DOI: 10.1073/pnas.0538077100  0.56
2003 Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR, ... Sacchettini JC, et al. Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. The Journal of Biological Chemistry. 278: 20851-9. PMID 12606558 DOI: 10.1074/jbc.M211968200  0.56
2002 Riley-Lovingshimer MR, Ronning DR, Sacchettini JC, Reinhart GD. Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus. Biochemistry. 41: 12967-74. PMID 12390023 DOI: 10.1021/bi0263412  0.56
2002 Yang D, Shipman LW, Roessner CA, Scott AI, Sacchettini JC. Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily. The Journal of Biological Chemistry. 277: 9462-7. PMID 11751891 DOI: 10.1074/jbc.M110787200  0.56
2001 Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC. Crystal structure of precorrin-8x methyl mutase. Structure (London, England : 1993). 9: 587-96. PMID 11470433 DOI: 10.1016/S0969-2126(01)00618-9  0.56
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