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James C. Sacchettini - Publications

Affiliations: 
Texas A & M University, College Station, TX, United States 
Area:
Biochemistry
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Year Citation  Score
2024 Singh A, Ottavi S, Krieger I, Planck K, Perkowski A, Kaneko T, Davis AM, Suh C, Zhang D, Goullieux L, Alex A, Roubert C, Gardner M, Preston M, Smith DM, ... ... Sacchettini JC, et al. Redirecting raltitrexed from cancer cell thymidylate synthase to phosphopantetheinyl transferase. Science Advances. 10: eadj6406. PMID 38489355 DOI: 10.1126/sciadv.adj6406  0.306
2022 Singh V, Grzegorzewicz AE, Fienberg S, Müller R, Khonde LP, Sanz O, Alfonso S, Urones B, Drewes G, Bantscheff M, Ghidelli-Disse S, Ioerger TR, Angala B, Liu J, Lee RE, ... Sacchettini JC, et al. 1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in . Acs Infectious Diseases. 8: 2315-2326. PMID 36325756 DOI: 10.1021/acsinfecdis.2c00392  0.308
2020 Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA. A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife. 9. PMID 32780017 DOI: 10.7554/Elife.57081  0.358
2020 Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet JE, Arthur M, Sacchettini JC, et al. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. Frontiers in Microbiology. 11: 1248. PMID 32655524 DOI: 10.3389/Fmicb.2020.01248  0.375
2020 Krieger I, Kuznetsov V, Chang JY, Zhang J, Moussa S, Young R, Sacchettini JC. The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition. Journal of Molecular Biology. PMID 32562709 DOI: 10.1016/J.Jmb.2020.06.013  0.319
2020 Jansen RS, Mandyoli L, Hughes R, Wakabayashi S, Pinkham JT, Selbach B, Guinn KM, Rubin EJ, Sacchettini JC, Rhee KY. Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis. Nature Communications. 11: 1960. PMID 32327655 DOI: 10.1038/S41467-020-15876-8  0.388
2020 Taira J, Umei T, Inoue K, Kitamura M, Berenger F, Sacchettini JC, Sakamoto H, Aoki S. Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening. The Journal of Antibiotics. PMID 32152525 DOI: 10.1038/S41429-020-0293-6  0.394
2020 Sun Q, Li X, Perez LM, Shi W, Zhang Y, Sacchettini JC. The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. Nature Communications. 11: 339. PMID 31953389 DOI: 10.2210/Pdb6Oyy/Pdb  0.428
2020 Khan D, Lee D, Gulten G, Aggarwal A, Wofford J, Krieger I, Tripathi A, Patrick JW, Eckert DM, Laganowsky A, Sacchettini J, Lindahl P, Bankaitis VA. Author response: A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins Elife. DOI: 10.7554/Elife.57081.Sa2  0.319
2019 Mosior J, Bourland R, Soma S, Nathan C, Sacchettini J. Structural Insights into Phosphopantetheinyl Hydrolase PptH from Mycobacterium tuberculosis. Protein Science : a Publication of the Protein Society. PMID 31886928 DOI: 10.1002/Pro.3813  0.462
2019 Tang S, Hicks ND, Cheng YS, Silva A, Fortune SM, Sacchettini JC. Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Research. PMID 31504787 DOI: 10.1093/Nar/Gkz724  0.348
2019 Brown EE, Miller AK, Krieger IV, Otto RM, Sacchettini JC, Herman JK. A DNA-binding protein tunes septum placement during sporulation. Journal of Bacteriology. PMID 31160399 DOI: 10.1128/Jb.00287-19  0.315
2019 Farhat MR, Freschi L, Calderon R, Ioerger T, Snyder M, Meehan CJ, de Jong B, Rigouts L, Sloutsky A, Kaur D, Sunyaev S, van Soolingen D, Shendure J, Sacchettini J, Murray M. GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions. Nature Communications. 10: 2128. PMID 31086182 DOI: 10.1038/S41467-019-10110-6  0.317
2019 Crespo RA, Dang Q, Zhou NE, Guthrie LM, Snavely TC, Dong W, Loesch KA, Suzuki T, You L, Wang W, O'Malley T, Parish T, Olsen DB, Sacchettini JC. Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. Journal of Medicinal Chemistry. PMID 31002508 DOI: 10.2210/Pdb6C9P/Pdb  0.435
2019 Salazar AJ, Sherekar M, Tsai J, Sacchettini JC. R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold. Plos One. 14: e0211432. PMID 30721244 DOI: 10.2210/Pdb6Cxb/Pdb  0.319
2019 Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, ... ... Sacchettini J, et al. Opposing reactions in coenzyme A metabolism sensitize to enzyme inhibition. Science (New York, N.Y.). 363. PMID 30705156 DOI: 10.1126/Science.Aau8959  0.404
2019 Miller BK, Hughes R, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, Sacchettini JC, Braunstein M. SatS is a chaperone for the SecA2 protein export pathway. Elife. 8. PMID 30604681 DOI: 10.7554/Elife.40063  0.373
2018 Rittershaus ESC, Baek SH, Krieger IV, Nelson SJ, Cheng YS, Nambi S, Baker RE, Leszyk JD, Shaffer SA, Sacchettini JC, Sassetti CM. A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis. Cell Chemical Biology. PMID 30318462 DOI: 10.1016/J.Chembiol.2018.09.009  0.377
2018 Melief E, Kokoczka R, Files M, Bailey MA, Alling T, Li H, Ahn J, Misquith A, Korkegian A, Roberts D, Sacchettini J, Parish T. Construction of an overexpression library for . Biology Methods & Protocols. 3: bpy009. PMID 30197930 DOI: 10.1093/Biomethods/Bpy009  0.348
2018 Ellenbarger J, Krieger I, Huang HL, Gómez-Coca S, Ioerger TR, Sacchettini JC, Wheeler SE, Dunbar KR. Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. Journal of Chemical Information and Modeling. PMID 30137983 DOI: 10.1021/acs.jcim.8b00417  0.392
2018 Shen Q, Bhatt VS, Krieger I, Sacchettini JC, Cho JH. Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase. Medchemcomm. 9: 519-524. PMID 30108942 DOI: 10.1039/C7Md00619E  0.301
2018 Blanc L, Sarathy JP, Alvarez Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Sacchettini J, Savic RM, Gengenbacher M, Podell BK, Prideaux B, Ioerger T, Dick T, Dartois V. Impact of immunopathology on the antituberculous activity of pyrazinamide. The Journal of Experimental Medicine. PMID 30018074 DOI: 10.1084/Jem.20180518  0.305
2018 Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Science Translational Medicine. 10. PMID 29695454 DOI: 10.1126/Scitranslmed.Aal1803  0.378
2018 Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T. The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 108: 96-98. PMID 29523334 DOI: 10.1016/J.Tube.2017.11.003  0.351
2018 Murugesan D, Ray PC, Bayliss T, Prosser GA, Harrison JR, Green K, Soares de Melo C, Feng TS, Street LJ, Chibale K, Warner DF, Mizrahi V, Epemolu O, Scullion P, Ellis L, ... ... Sacchettini J, et al. 2-Mercapto-quinazolinones as inhibitors of NDH-2 and Mycobacterium tuberculosis: Structure-activity relationships, mechanism of action and ADME characterization. Acs Infectious Diseases. PMID 29522317 DOI: 10.1021/Acsinfecdis.7B00275  0.455
2018 Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, et al. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 29465985 DOI: 10.1021/Acsinfecdis.7B00111  0.373
2018 Miller BK, Hughes R, Ligon LS, Rigel NW, Malik S, Anjuwon-Foster BR, Sacchettini JC, Braunstein M. Author response: Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway Elife. DOI: 10.7554/Elife.40063.028  0.328
2017 Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Bach NC, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA. An antibacterial β-lactone kills Mycobacterium tuberculosis by infiltrating mycolic acid biosynthesis. Angewandte Chemie (International Ed. in English). PMID 29067779 DOI: 10.1002/Anie.201709365  0.383
2017 Chandrasekara NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini JC, Masquelin T, Hipskind PA, Odingo J, Parish T. Improved phenoxyalkylbenzimidazoles with activity against Mycobacterium tuberculosis appear to target QcrB. Acs Infectious Diseases. PMID 29035551 DOI: 10.1021/Acsinfecdis.7B00112  0.379
2017 Yang K, Chang JY, Cui Z, Li X, Meng R, Duan L, Thongchol J, Jakana J, Huwe CM, Sacchettini JC, Zhang J. Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Research. PMID 28977617 DOI: 10.1093/Nar/Gkx785  0.378
2017 Taira J, Morita K, Kawashima S, Umei T, Baba H, Maruoka T, Komatsu H, Sakamoto H, Sacchettini JC, Aoki S. Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening. The Journal of Antibiotics. PMID 28951604 DOI: 10.1038/Ja.2017.106  0.4
2017 Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS. A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nature Communications. 8: 588. PMID 28928454 DOI: 10.1038/S41467-017-00721-2  0.318
2017 Thapa HR, Tang S, Sacchettini JC, Devarenne TP. Tetraterpene synthase substrate and product specificity in the green microalga Botryococcus braunii race L. Acs Chemical Biology. PMID 28813599 DOI: 10.1021/Acschembio.7B00457  0.358
2017 Pham TV, Murkin AS, Moynihan MM, Harris L, Tyler PC, Shetty N, Sacchettini JC, Huang HL, Meek TD. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28679637 DOI: 10.1073/Pnas.1706134114  0.39
2017 Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T. A novel 6-benzyl ether benzoxaborole is active against Mycobacterium tuberculosis in vitro. Antimicrobial Agents and Chemotherapy. PMID 28674058 DOI: 10.1128/Aac.01205-17  0.336
2017 Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, ... ... Sacchettini JC, et al. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. PMID 28669536 DOI: 10.1016/J.Cell.2017.06.025  0.403
2017 Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M. The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection. Mbio. 8. PMID 28442606 DOI: 10.1128/Mbio.00333-17  0.344
2017 Puckett S, Trujillo C, Wang Z, Eoh H, Ioerger TR, Krieger I, Sacchettini J, Schnappinger D, Rhee KY, Ehrt S. Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28265055 DOI: 10.1073/Pnas.1617655114  0.337
2017 Zhu M, Harshbarger WD, Robles O, Krysiak J, Hull KG, Cho SW, Richardson RD, Yang Y, Garcia A, Spiegelman L, Ramirez B, Wilson CT, Yau JA, Moore JT, Walker CB, ... Sacchettini JC, et al. A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. Bioorganic & Medicinal Chemistry. PMID 28236510 DOI: 10.1016/J.Bmc.2017.01.020  0.385
2016 Huang HL, Krieger IV, Parai MK, Gawandi VB, Sacchettini JC. Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange. The Journal of Biological Chemistry. PMID 27738104 DOI: 10.1074/Jbc.M116.750877  0.452
2016 Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee KY, Breda A, et al. Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27704782 DOI: 10.1021/Acsinfecdis.6B00103  0.408
2016 Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, ... ... Sacchettini JC, et al. Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase. Antimicrobial Agents and Chemotherapy. PMID 27503647 DOI: 10.1128/Aac.01339-16  0.41
2016 Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, ... ... Sacchettini JC, et al. Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor. Ebiomedicine. 8: 291-301. PMID 27428438 DOI: 10.1016/J.Ebiom.2016.05.006  0.397
2016 Bhatt VS, Zeng D, Krieger I, Sacchettini JC, Cho JH. Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl. Biophysical Journal. 110: 2630-2641. PMID 27332121 DOI: 10.1016/J.Bpj.2016.05.008  0.354
2016 Almeida D, Ioerger T, Tyagi S, Li SY, Mdluli K, Andries K, Grosset J, Sacchettini J, Nuermberger E. Mutations in pepQ Confer Low-level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. PMID 27185800 DOI: 10.1128/Aac.00753-16  0.335
2016 Guardia A, Gulten G, Fernandez R, Gómez J, Wang F, Convery M, Blanco D, Martínez M, Pérez-Herrán E, Alonso M, Ortega F, Rullás J, Calvo D, Mata L, Young R, ... Sacchettini JC, et al. N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity. Chemmedchem. PMID 26934341 DOI: 10.1002/Cmdc.201600020  0.455
2016 Bageshwar UK, VerPlank L, Baker D, Dong W, Hamsanathan S, Whitaker N, Sacchettini JC, Musser SM. High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors. Plos One. 11: e0149659. PMID 26901445 DOI: 10.1371/Journal.Pone.0149659  0.329
2016 Cheng YS, Sacchettini JC. Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry. PMID 26848874 DOI: 10.1021/Acs.Biochem.5B00993  0.47
2016 Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. Plos Pathogens. 12: e1005351. PMID 26751071 DOI: 10.1371/Journal.Ppat.1005351  0.3
2015 Swanson S, Ioerger TR, Rigel NW, Miller BK, Braunstein M, Sacchettini JC. Structural similarities and differences between two functionally distinct SecA proteins: the Mycobacterium tuberculosis SecA1 and SecA2. Journal of Bacteriology. PMID 26668263 DOI: 10.1128/Jb.00696-15  0.414
2015 Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C. Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland). 95: 689-94. PMID 26547230 DOI: 10.1016/J.Tube.2015.08.009  0.315
2015 Hong W, Wang Y, Chang Z, Yang Y, Pu J, Sun T, Kaur S, Sacchettini JC, Jung H, Lin Wong W, Fah Yap L, Fong Ngeow Y, Paterson IC, Wang H. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling. Scientific Reports. 5: 15328. PMID 26471125 DOI: 10.1038/Srep15328  0.412
2015 Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proceedings of the National Academy of Sciences of the United States of America. 112: 13087-92. PMID 26438867 DOI: 10.1073/Pnas.1514135112  0.353
2015 Li X, Sun Q, Jiang C, Yang K, Hung LW, Zhang J, Sacchettini JC. Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. Structure (London, England : 1993). PMID 26299947 DOI: 10.1016/J.Str.2015.07.014  0.398
2015 Kanetaka H, Koseki Y, Taira J, Umei T, Komatsu H, Sakamoto H, Gulten G, Sacchettini JC, Kitamura M, Aoki S. Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach. European Journal of Medicinal Chemistry. 94: 378-85. PMID 25778993 DOI: 10.1016/J.Ejmech.2015.02.062  0.422
2015 Harshbarger W, Miller C, Diedrich C, Sacchettini J. Crystal structure of the human 20S proteasome in complex with carfilzomib Structure. 23: 418-424. DOI: 10.1016/J.Str.2014.11.017  0.385
2014 Prigozhin DM, Krieger IV, Huizar JP, Mavrici D, Waldo GS, Hung LW, Sacchettini JC, Terwilliger TC, Alber T. Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis. Plos One. 9: e116249. PMID 25551456 DOI: 10.1371/Journal.Pone.0116249  0.471
2014 Odingo J, O'Malley T, Kesicki EA, Alling T, Bailey MA, Early J, Ollinger J, Dalai S, Kumar N, Singh RV, Hipskind PA, Cramer JW, Ioerger T, Sacchettini J, Vickers R, et al. Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents. Bioorganic & Medicinal Chemistry. 22: 6965-79. PMID 25456390 DOI: 10.1016/J.Bmc.2014.10.007  0.385
2014 Reddy MC, Breda A, Bruning JB, Sherekar M, Valluru S, Thurman C, Ehrenfeld H, Sacchettini JC. Structure, activity, and inhibition of the Carboxyltransferase β-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 58: 6122-32. PMID 25092705 DOI: 10.1128/Aac.02574-13  0.417
2014 Nixon MR, Saionz KW, Koo MS, Szymonifka MJ, Jung H, Roberts JP, Nandakumar M, Kumar A, Liao R, Rustad T, Sacchettini JC, Rhee KY, Freundlich JS, Sherman DR. Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis. Chemistry & Biology. 21: 819-30. PMID 24954008 DOI: 10.1016/J.Chembiol.2014.04.009  0.36
2014 Kim Y, Cunningham M, Tesar C, Jedrzejczak R, Mire J, Binkowski A, Babnigg G, Sacchettini J, Joachimiak A. Carbapenemase NDM-1, Structural Analysis of the Catalytic Mechanism Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314091815  0.331
2013 Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. Plos One. 8: e77844. PMID 24265677 DOI: 10.1371/Journal.Pone.0077844  0.313
2013 Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. Plos One. 8: e75245. PMID 24086479 DOI: 10.1371/Journal.Pone.0075245  0.404
2013 Gulten G, Sacchettini JC. Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD. Structure (London, England : 1993). 21: 1859-69. PMID 24055315 DOI: 10.1016/J.Str.2013.08.014  0.368
2013 Small JL, Park SW, Kana BD, Ioerger TR, Sacchettini JC, Ehrt S. Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis. Mbio. 4: e00475-13. PMID 24045640 DOI: 10.1128/Mbio.00475-13  0.365
2013 Lanzas F, Karakousis PC, Sacchettini JC, Ioerger TR. Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa. Journal of Clinical Microbiology. 51: 3277-85. PMID 23884993 DOI: 10.1128/Jcm.01122-13  0.322
2013 Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD. Redefining the role of the quaternary shift in Bacillus stearothermophilus phosphofructokinase. Biochemistry. 52: 5421-9. PMID 23859543 DOI: 10.1021/Bi4002503  0.399
2013 Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proceedings of the National Academy of Sciences of the United States of America. 110: 11565-70. PMID 23798446 DOI: 10.1073/Pnas.1302114110  0.41
2013 Liu Z, Ioerger TR, Wang F, Sacchettini JC. Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme. The Journal of Biological Chemistry. 288: 18473-83. PMID 23625916 DOI: 10.1074/Jbc.M113.466912  0.44
2013 Gokulan K, O'Leary SE, Russell WK, Russell DH, Lalgondar M, Begley TP, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. The Journal of Biological Chemistry. 288: 16484-94. PMID 23615910 DOI: 10.1074/Jbc.M113.468892  0.43
2013 Kinjo T, Koseki Y, Kobayashi M, Yamada A, Morita K, Yamaguchi K, Tsurusawa R, Gulten G, Komatsu H, Sakamoto H, Sacchettini JC, Kitamura M, Aoki S. Identification of compounds with potential antibacterial activity against Mycobacterium through structure-based drug screening. Journal of Chemical Information and Modeling. 53: 1200-12. PMID 23600706 DOI: 10.1021/Ci300571N  0.388
2013 Gopinath K, Venclovas C, Ioerger TR, Sacchettini JC, McKinney JD, Mizrahi V, Warner DF. A vitamin B₁₂ transporter in Mycobacterium tuberculosis. Open Biology. 3: 120175. PMID 23407640 DOI: 10.1098/Rsob.120175  0.364
2013 Kim Y, Cunningham MA, Mire J, Tesar C, Sacchettini J, Joachimiak A. NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism The Faseb Journal. 27: 1917-1927. PMID 23363572 DOI: 10.1096/Fj.12-224014  0.356
2013 Anderson JW, Sarantakis D, Terpinski J, Kumar TR, Tsai HC, Kuo M, Ager AL, Jacobs WR, Schiehser GA, Ekins S, Sacchettini JC, Jacobus DP, Fidock DA, Freundlich JS. Novel diaryl ureas with efficacy in a mouse model of malaria. Bioorganic & Medicinal Chemistry Letters. 23: 1022-5. PMID 23313245 DOI: 10.1016/J.Bmcl.2012.12.022  0.776
2013 DeJesus MA, Sacchettini JC, Ioerger TR. Reannotation of translational start sites in the genome of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 93: 18-25. PMID 23273318 DOI: 10.1016/J.Tube.2012.11.012  0.319
2012 Krieger IV, Freundlich JS, Gawandi VB, Roberts JP, Gawandi VB, Sun Q, Owen JL, Fraile MT, Huss SI, Lavandera JL, Ioerger TR, Sacchettini JC. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chemistry & Biology. 19: 1556-67. PMID 23261599 DOI: 10.1016/J.Chembiol.2012.09.018  0.448
2012 Xie H, Mire J, Kong Y, Chang M, Hassounah HA, Thornton CN, Sacchettini JC, Cirillo JD, Rao J. Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe. Nature Chemistry. 4: 802-9. PMID 23000993 DOI: 10.1038/Nchem.1435  0.328
2012 James JN, Hasan ZU, Ioerger TR, Brown AC, Personne Y, Carroll P, Ikeh M, Tilston-Lunel NL, Palavecino C, Sacchettini JC, Parish T. Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions. Microbiology (Reading, England). 158: 2724-31. PMID 22956756 DOI: 10.1099/Mic.0.060319-0  0.302
2012 Chia BS, Lanzas F, Rifat D, Herrera A, Kim EY, Sailer C, Torres-Chavolla E, Narayanaswamy P, Einarsson V, Bravo J, Pascale JM, Ioerger TR, Sacchettini JC, Karakousis PC. Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama. Plos One. 7: e40456. PMID 22792333 DOI: 10.1371/Journal.Pone.0040456  0.327
2012 Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Science : a Publication of the Protein Society. 21: 571-82. PMID 22389108 DOI: 10.1002/Pro.2042  0.303
2012 Mosser R, Reddy MC, Bruning JB, Sacchettini JC, Reinhart GD. Structure of the apo form of Bacillus stearothermophilus phosphofructokinase. Biochemistry. 51: 769-75. PMID 22212099 DOI: 10.1021/Bi201548P  0.395
2012 La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrobial Agents and Chemotherapy. 56: 324-31. PMID 22024828 DOI: 10.1128/Aac.05270-11  0.386
2011 Kim Y, Tesar C, Mire J, Jedrzejczak R, Binkowski A, Babnigg G, Sacchettini JC, Joachimiak A. Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase. Plos One. 6. PMID 21931780 DOI: 10.1371/Journal.Pone.0024621  0.324
2011 Lotesta SD, Liu J, Yates EV, Krieger I, Sacchettini JC, Freundlich JS, Sorensen EJ. Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis. Chemical Science (Royal Society of Chemistry : 2010). 2: 1258-1261. PMID 21874155 DOI: 10.1039/C1Sc00116G  0.38
2011 Gokulan K, Aggarwal A, Shipman L, Besra GS, Sacchettini JC. Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. Acta Crystallographica. Section D, Biological Crystallography. 67: 657-69. PMID 21697604 DOI: 10.1107/S0907444911020221  0.781
2011 Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR. Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions. Antimicrobial Agents and Chemotherapy. 55: 3889-98. PMID 21628538 DOI: 10.1128/Aac.00266-11  0.794
2011 Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nature Genetics. 43: 482-6. PMID 21516081 DOI: 10.1038/Ng.811  0.307
2011 Picaud S, Kavanagh KL, Yue WW, Lee WH, Muller-Knapp S, Gileadi O, Sacchettini J, Oppermann U. Structural basis of fumarate hydratase deficiency. Journal of Inherited Metabolic Disease. 34: 671-6. PMID 21445611 DOI: 10.1007/S10545-011-9294-8  0.349
2011 Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/Bj20110002  0.46
2011 Arockiasamy A, Aggarwal A, Savva CG, Holzenburg A, Sacchettini JC. Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site. Protein Science : a Publication of the Protein Society. 20: 827-33. PMID 21370306 DOI: 10.1002/Pro.607  0.358
2011 Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, ... ... Sacchettini JC, et al. The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinburgh, Scotland). 91: 155-72. PMID 21247804 DOI: 10.1016/J.Tube.2010.11.009  0.413
2011 Bruning JB, Murillo AC, Chacon O, Barletta RG, Sacchettini JC. Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine. Antimicrobial Agents and Chemotherapy. 55: 291-301. PMID 20956591 DOI: 10.1128/Aac.00558-10  0.386
2010 Molle V, Gulten G, Vilchèze C, Veyron-Churlet R, Zanella-Cléon I, Sacchettini JC, Jacobs WR, Kremer L. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Molecular Microbiology. 78: 1591-605. PMID 21143326 DOI: 10.1111/J.1365-2958.2010.07446.X  0.404
2010 Ioerger TR, Feng Y, Chen X, Dobos KM, Victor TC, Streicher EM, Warren RM, Gey van Pittius NC, Van Helden PD, Sacchettini JC. The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa. Bmc Genomics. 11: 670. PMID 21110864 DOI: 10.1186/1471-2164-11-670  0.325
2010 Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC. The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 90: 298-300. PMID 20739223 DOI: 10.1016/J.Tube.2010.08.002  0.355
2010 Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nature Structural & Molecular Biology. 17: 1088-95. PMID 20694006 DOI: 10.1038/Nsmb.1869  0.348
2010 Kong Y, Yao H, Ren H, Subbian S, Cirillo SL, Sacchettini JC, Rao J, Cirillo JD. Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 12239-44. PMID 20566877 DOI: 10.1073/Pnas.1000643107  0.317
2010 Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilchèze C, Jacobs WR, Sacchettini JC. Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid. Antimicrobial Agents and Chemotherapy. 54: 3776-82. PMID 20566771 DOI: 10.1128/Aac.00453-10  0.385
2010 Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 49: 6746-60. PMID 20565114 DOI: 10.1021/Bi902097J  0.655
2010 Shetty ND, Reddy MC, Palaninathan SK, Owen JL, Sacchettini JC. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Science : a Publication of the Protein Society. 19: 1513-24. PMID 20521335 DOI: 10.1002/Pro.430  0.423
2010 Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nature Chemical Biology. 6: 376-84. PMID 20305657 DOI: 10.1038/Nchembio.340  0.348
2010 Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini JC, Stoker NG, Kaplan G, Mizrahi V. Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis. Journal of Bacteriology. 192: 2220-7. PMID 20139184 DOI: 10.1128/Jb.01135-09  0.358
2010 Mosser R, Reddy M, Bruning J, Sacchettini JC, Reinhart GD. Redefining the Role of the Quaternary Shift in the Allosteric Inhibition of Bacillus Stearothermophilus Phosphofructokinase Biophysical Journal. 98: 39a. DOI: 10.1016/J.Bpj.2009.12.226  0.385
2009 Musa TL, Ioerger TR, Sacchettini JC. The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery. Advances in Protein Chemistry and Structural Biology. 77: 41-76. PMID 20663481 DOI: 10.1016/S1876-1623(09)77003-8  0.403
2009 Ioerger TR, Koo S, No EG, Chen X, Larsen MH, Jacobs WR, Pillay M, Sturm AW, Sacchettini JC. Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa. Plos One. 4: e7778. PMID 19890396 DOI: 10.1371/Journal.Pone.0007778  0.321
2009 Reddy MC, Palaninathan SK, Bruning JB, Thurman C, Smith D, Sacchettini JC. Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein. The Journal of Biological Chemistry. 284: 36581-91. PMID 19740754 DOI: 10.1074/Jbc.M109.041343  0.38
2009 Palaninathan SK, Mohamedmohaideen NN, Orlandini E, Ortore G, Nencetti S, Lapucci A, Rossello A, Freundlich JS, Sacchettini JC. Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis. Plos One. 4: e6290. PMID 19621084 DOI: 10.1371/Journal.Pone.0006290  0.4
2009 Swanson S, Gokulan K, Sacchettini JC. KasA, another brick in the mycobacterial cell wall. Structure (London, England : 1993). 17: 914-5. PMID 19604470 DOI: 10.1016/J.Str.2009.06.006  0.331
2009 Payne K, Sun Q, Sacchettini J, Hatfull GF. Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase. Molecular Microbiology. 73: 367-81. PMID 19555454 DOI: 10.1111/J.1365-2958.2009.06775.X  0.34
2009 Ioerger TR, Sacchettini JC. Structural genomics approach to drug discovery for Mycobacterium tuberculosis. Current Opinion in Microbiology. 12: 318-25. PMID 19481971 DOI: 10.1016/J.Mib.2009.04.006  0.421
2009 Barkan D, Liu Z, Sacchettini JC, Glickman MS. Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis. Chemistry & Biology. 16: 499-509. PMID 19477414 DOI: 10.1016/J.Chembiol.2009.04.001  0.399
2009 Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR, Sacchettini JC. Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis. Chemmedchem. 4: 241-8. PMID 19130456 DOI: 10.1002/Cmdc.200800261  0.457
2009 Mosser R, Reddy M, Sacchettini JC, Igumenova T, Reinhart GD. A Solution NMR and Crystallographic Study of the Role of the Quaternary Shift in the Allosteric Regulation of Phosphofructokinase from B. stearothermophilus Biophysical Journal. 96: 5a. DOI: 10.1016/J.Bpj.2008.12.917  0.392
2008 Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC. Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Science : a Publication of the Protein Society. 17: 2134-44. PMID 18815415 DOI: 10.1110/Ps.038125.108  0.435
2008 Cho Y, Ioerger TR, Sacchettini JC. Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. Journal of Medicinal Chemistry. 51: 5984-92. PMID 18778048 DOI: 10.1021/Jm800328V  0.426
2008 Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. Journal of Molecular Biology. 382: 1157-67. PMID 18662699 DOI: 10.1016/J.Jmb.2008.07.029  0.356
2008 Vilchèze C, Av-Gay Y, Attarian R, Liu Z, Hazbón MH, Colangeli R, Chen B, Liu W, Alland D, Sacchettini JC, Jacobs WR. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Molecular Microbiology. 69: 1316-29. PMID 18651841 DOI: 10.1111/J.1365-2958.2008.06365.X  0.357
2008 Dey S, Burton RL, Grant GA, Sacchettini JC. Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase. Biochemistry. 47: 8271-82. PMID 18627175 DOI: 10.1021/Bi800212B  0.629
2008 Javid-Majd F, Yang D, Ioerger TR, Sacchettini JC. The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis. Acta Crystallographica. Section D, Biological Crystallography. 64: 627-35. PMID 18560150 DOI: 10.1107/S0907444908007105  0.459
2008 Zwart PH, Afonine PV, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, McKee E, Moriarty NW, Read RJ, Sacchettini JC, Sauter NK, Storoni LC, Terwilliger TC, Adams PD. Automated structure solution with the PHENIX suite. Methods in Molecular Biology (Clifton, N.J.). 426: 419-35. PMID 18542881 DOI: 10.1007/978-1-60327-058-8_28  0.314
2008 Mohamedmohaideen NN, Palaninathan SK, Morin PM, Williams BJ, Braunstein M, Tichy SE, Locker J, Russell DH, Jacobs WR, Sacchettini JC. Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis. Biochemistry. 47: 6092-102. PMID 18479146 DOI: 10.1021/Bi701929M  0.409
2008 Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nature Reviews. Microbiology. 6: 41-52. PMID 18079742 DOI: 10.1038/Nrmicro1816  0.328
2008 Bhardwaj K, Palaninathan S, Alcantara JM, Yi LL, Guarino L, Sacchettini JC, Kao CC. Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15. The Journal of Biological Chemistry. 283: 3655-64. PMID 18045871 DOI: 10.1074/Jbc.M708375200  0.32
2008 Reddy MC, Gokulan K, Jacobs WR, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response. Protein Science : a Publication of the Protein Society. 17: 159-70. PMID 18042675 DOI: 10.1110/Ps.073192208  0.436
2008 Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR. Mechanisms for isoniazid action and resistance. Novartis Foundation Symposium. 217: 209-221. PMID 9949810 DOI: 10.1002/0470846526.Ch15  0.392
2008 Giddens AC, Nielsen L, Boshoff HI, Tasdemir D, Perozzo R, Kaiser M, Wang F, Sacchettini JC, Copp BR. Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities Tetrahedron. 64: 1242-1249. DOI: 10.1016/J.Tet.2007.11.075  0.36
2007 Alahari A, Trivelli X, Guérardel Y, Dover LG, Besra GS, Sacchettini JC, Reynolds RC, Coxon GD, Kremer L. Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. Plos One. 2: e1343. PMID 18094751 DOI: 10.1371/Journal.Pone.0001343  0.358
2007 Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, ... ... Sacchettini JC, et al. High throughput crystallography of TB drug targets. Infectious Disorders Drug Targets. 7: 127-39. PMID 17970224 DOI: 10.2174/187152607781001853  0.405
2007 Reddy MC, Palaninathan SK, Shetty ND, Owen JL, Watson MD, Sacchettini JC. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. The Journal of Biological Chemistry. 282: 27334-42. PMID 17597075 DOI: 10.1074/Jbc.M703290200  0.448
2007 Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR, Schiehser GA, Jacobus DP, Fidock DA, ... Sacchettini JC, et al. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. The Journal of Biological Chemistry. 282: 25436-44. PMID 17567585 DOI: 10.1074/Jbc.M701813200  0.811
2007 Tsai CL, Gokulan K, Sobrado P, Sacchettini JC, Fitzpatrick PF. Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base. Biochemistry. 46: 7844-51. PMID 17563122 DOI: 10.1021/Bi7005543  0.363
2007 Cai X, Lorraine Fuller A, McDougald LR, Tan X, Cai J, Wang F, Sacchettini JC, Zhu G. Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa). Fems Microbiology Letters. 272: 238-44. PMID 17559403 DOI: 10.1111/J.1574-6968.2007.00767.X  0.371
2007 Wang F, Langley R, Gulten G, Wang L, Sacchettini JC. Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence. Chemistry & Biology. 14: 543-51. PMID 17524985 DOI: 10.1016/J.Chembiol.2007.04.005  0.427
2007 Nicola G, Smith CA, Lucumi E, Kuo MR, Karagyozov L, Fidock DA, Sacchettini JC, Abagyan R. Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening. Biochemical and Biophysical Research Communications. 358: 686-91. PMID 17509532 DOI: 10.1016/J.Bbrc.2007.04.113  0.802
2007 Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA. The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase. The Journal of Biological Chemistry. 282: 18418-26. PMID 17459882 DOI: 10.1074/Jbc.M701174200  0.602
2007 Ramesh A, Savva CG, Holzenburg A, Sacchettini JC. Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity. The Journal of Biological Chemistry. 282: 14960-7. PMID 17392270 DOI: 10.1074/Jbc.M611163200  0.547
2007 Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR, Sacchettini JC. Mechanism of thioamide drug action against tuberculosis and leprosy. The Journal of Experimental Medicine. 204: 73-8. PMID 17227913 DOI: 10.1084/Jem.20062100  0.381
2007 Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC. X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). Journal of Molecular Biology. 366: 469-80. PMID 17174327 DOI: 10.1016/J.Jmb.2006.11.006  0.466
2007 Liu T, Ramesh A, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP. CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. Nature Chemical Biology. 3: 60-8. PMID 17143269 DOI: 10.1038/Nchembio844  0.56
2007 Gopal K, McKee E, Romo T, Pai R, Smith J, Sacchettini J, Ioerger T. Crystallographic protein model-building on the web. Bioinformatics (Oxford, England). 23: 375-7. PMID 17138588 DOI: 10.1093/Bioinformatics/Btl584  0.307
2007 Sidhu AB, Sun Q, Nkrumah LJ, Dunne MW, Sacchettini JC, Fidock DA. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. The Journal of Biological Chemistry. 282: 2494-504. PMID 17110371 DOI: 10.1074/Jbc.M608615200  0.354
2006 Vilchèze C, Wang F, Arai M, Hazbón MH, Colangeli R, Kremer L, Weisbrod TR, Alland D, Sacchettini JC, Jacobs WR. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nature Medicine. 12: 1027-9. PMID 16906155 DOI: 10.1038/Nm1466  0.388
2006 Gould TA, van de Langemheen H, Muñoz-Elías EJ, McKinney JD, Sacchettini JC. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Molecular Microbiology. 61: 940-7. PMID 16879647 DOI: 10.1111/J.1365-2958.2006.05297.X  0.437
2006 Wang F, Cassidy C, Sacchettini JC. Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics. Antimicrobial Agents and Chemotherapy. 50: 2762-71. PMID 16870770 DOI: 10.1128/Aac.00320-06  0.407
2006 Owens RM, Hsu FF, VanderVen BC, Purdy GE, Hesteande E, Giannakas P, Sacchettini JC, McKinney JD, Hill PJ, Belisle JT, Butcher BA, Pethe K, Russell DG. M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Molecular Microbiology. 60: 1152-63. PMID 16689792 DOI: 10.1111/J.1365-2958.2006.05174.X  0.345
2006 Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS. Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant. Biochemistry. 45: 4131-40. PMID 16566587 DOI: 10.1021/Bi051967O  0.436
2006 Freundlich JS, Yu M, Lucumi E, Kuo M, Tsai HC, Valderramos JC, Karagyozov L, Jacobs WR, Schiehser GA, Fidock DA, Jacobus DP, Sacchettini JC. Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 16: 2163-9. PMID 16466916 DOI: 10.1016/J.Bmcl.2006.01.051  0.799
2006 Freundlich JS, Anderson JW, Sarantakis D, Shieh H, Yu M, Valderramos J, Lucumi E, Kuo M, Jacobs WR, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC. Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 5247–5252] Bioorganic & Medicinal Chemistry Letters. 16: 3618-3619. DOI: 10.1016/J.Bmcl.2005.12.054  0.795
2005 Paricharttanakul NM, Ye S, Menefee AL, Javid-Majd F, Sacchettini JC, Reinhart GD. Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus. Biochemistry. 44: 15280-6. PMID 16285731 DOI: 10.1021/Bi051283G  0.386
2005 Bhatt A, Kremer L, Dai AZ, Sacchettini JC, Jacobs WR. Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. Journal of Bacteriology. 187: 7596-606. PMID 16267284 DOI: 10.1128/Jb.187.22.7596-7606.2005  0.39
2005 Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC. Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 15: 5247-52. PMID 16198563 DOI: 10.1016/J.Bmcl.2005.08.044  0.818
2005 Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS. Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. The Journal of Biological Chemistry. 280: 32539-47. PMID 16040614 DOI: 10.1074/Jbc.M413216200  0.392
2005 Gokulan K, Khare S, Ronning DR, Linthicum SD, Sacchettini JC, Rupp B. Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners. Biochemistry. 44: 9889-98. PMID 16026161 DOI: 10.1021/Bi050613U  0.674
2005 Colangeli R, Helb D, Sridharan S, Sun J, Varma-Basil M, Hazbón MH, Harbacheuski R, Megjugorac NJ, Jacobs WR, Holzenburg A, Sacchettini JC, Alland D. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Molecular Microbiology. 55: 1829-40. PMID 15752203 DOI: 10.1111/J.1365-2958.2005.04510.X  0.394
2005 Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. Journal of Medicinal Chemistry. 48: 1576-87. PMID 15743199 DOI: 10.1021/Jm049274D  0.349
2005 Sridharan S, Razvi A, Scholtz JM, Sacchettini JC. The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers. Journal of Molecular Biology. 346: 919-31. PMID 15713472 DOI: 10.1016/J.Jmb.2004.12.008  0.364
2005 Vilchèze C, Weisbrod TR, Chen B, Kremer L, Hazbón MH, Wang F, Alland D, Sacchettini JC, Jacobs WR. Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrobial Agents and Chemotherapy. 49: 708-20. PMID 15673755 DOI: 10.1128/Aac.49.2.708-720.2005  0.368
2005 Dey S, Hu Z, Xu XL, Sacchettini JC, Grant GA. D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes. The Journal of Biological Chemistry. 280: 14884-91. PMID 15668250 DOI: 10.1074/Jbc.M414488200  0.628
2005 Dey S, Grant GA, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits. The Journal of Biological Chemistry. 280: 14892-9. PMID 15668249 DOI: 10.1074/Jbc.M414489200  0.614
2005 Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of Biological Chemistry. 280: 8819-30. PMID 15625066 DOI: 10.1074/Jbc.M413184200  0.313
2005 Romo T, Gopal K, McKee E, Kanbi L, Pai R, Smith J, Sacchettini J, Ioerger T. TEXTAL: Al-based structural determination for X-ray protein crystallography Ieee Intelligent Systems. 20: 59-63. DOI: 10.1109/Mis.2005.114  0.375
2004 Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & Biology. 11: 1719-28. PMID 15610856 DOI: 10.1016/J.Chembiol.2004.10.009  0.305
2004 Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. The Journal of Biological Chemistry. 279: 36771-7. PMID 15192106 DOI: 10.1074/Jbc.M400811200  0.708
2004 Ye S, Vakonakis I, Ioerger TR, LiWang AC, Sacchettini JC. Crystal structure of circadian clock protein KaiA from Synechococcus elongatus. The Journal of Biological Chemistry. 279: 20511-8. PMID 15007067 DOI: 10.1074/Jbc.M400077200  0.387
2004 Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. Journal of Medicinal Chemistry. 47: 355-74. PMID 14711308 DOI: 10.1021/Jm030347N  0.394
2004 Smith CV, Sharma V, Sacchettini JC. TB drug discovery: addressing issues of persistence and resistance. Tuberculosis (Edinburgh, Scotland). 84: 45-55. PMID 14670345 DOI: 10.1016/J.Tube.2003.08.019  0.397
2003 Smith CV, Sacchettini JC. Mycobacterium tuberculosis: a model system for structural genomics. Current Opinion in Structural Biology. 13: 658-64. PMID 14675542 DOI: 10.1016/J.Sbi.2003.10.004  0.399
2003 Green NS, Palaninathan SK, Sacchettini JC, Kelly JW. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. Journal of the American Chemical Society. 125: 13404-14. PMID 14583036 DOI: 10.1021/Ja030294Z  0.386
2003 Eicken C, Pennella MA, Chen X, Koshlap KM, VanZile ML, Sacchettini JC, Giedroc DP. A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins. Journal of Molecular Biology. 333: 683-95. PMID 14568530 DOI: 10.1016/J.Jmb.2003.09.007  0.31
2003 Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, et al. The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology. Tuberculosis (Edinburgh, Scotland). 83: 223-49. PMID 12906835 DOI: 10.1016/S1472-9792(03)00051-9  0.402
2003 Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism. Biochemistry. 42: 7339-47. PMID 12809489 DOI: 10.1021/Bi0273617  0.377
2003 Kremer L, Dover LG, Morbidoni HR, Vilchèze C, Maughan WN, Baulard A, Tu SC, Honoré N, Deretic V, Sacchettini JC, Locht C, Jacobs WR, Besra GS. Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria. The Journal of Biological Chemistry. 278: 20547-54. PMID 12654922 DOI: 10.1074/Jbc.M302435200  0.352
2003 Gokulan K, Rupp B, Pavelka MS, Jacobs WR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis. The Journal of Biological Chemistry. 278: 18588-96. PMID 12637582 DOI: 10.1074/Jbc.M301549200  0.478
2003 Sharma V, Arockiasamy A, Ronning DR, Savva CG, Holzenburg A, Braunstein M, Jacobs WR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proceedings of the National Academy of Sciences of the United States of America. 100: 2243-8. PMID 12606717 DOI: 10.1073/Pnas.0538077100  0.691
2003 Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR, ... Sacchettini JC, et al. Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. The Journal of Biological Chemistry. 278: 20851-9. PMID 12606558 DOI: 10.1074/Jbc.M211968200  0.823
2003 Cho Y, Sharma V, Sacchettini JC. Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis. Journal of Biological Chemistry. 278: 8333-8339. PMID 12511575 DOI: 10.1074/Jbc.M212124200  0.456
2003 Smith CV, Huang CC, Miczak A, Russell DG, Sacchettini JC, Höner zu Bentrup K. Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 278: 1735-43. PMID 12393860 DOI: 10.1074/Jbc.M209248200  0.426
2003 Perozzo R, Kuo M, Sidhu AS, Valiyaveettil JT, Bittman R, WRJJ, Fidock DA, Sacchettini JC. Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase Year Journal of Biological Chemistry. 277: 13106-13114. DOI: 10.2210/Pdb1Nhw/Pdb  0.788
2003 Sun J, Sridharan S, Sacchettini J, Savva C, Holzenburg A. TEM Studies of IniA from Mycobacterium tuberculosis Microscopy and Microanalysis. 9: 1418-1419. DOI: 10.1017/S1431927603447090  0.317
2002 Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, ... ... Sacchettini J, et al. The TB structural genomics consortium: providing a structural foundation for drug discovery. Current Drug Targets. Infectious Disorders. 2: 121-41. PMID 12462144 DOI: 10.2174/1568005023342551  0.803
2002 Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis Molecular Microbiology. 46: 453-466. PMID 12406221 DOI: 10.1046/J.1365-2958.2002.03162.X  0.322
2002 Adams PD, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, Moriarty NW, Read RJ, Sacchettini JC, Sauter NK, Terwilliger TC. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallographica. Section D, Biological Crystallography. 58: 1948-54. PMID 12393927 DOI: 10.1107/S0907444902016657  0.33
2002 Riley-Lovingshimer MR, Ronning DR, Sacchettini JC, Reinhart GD. Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus. Biochemistry. 41: 12967-74. PMID 12390023 DOI: 10.1021/Bi0263412  0.688
2002 Eicken C, Sharma V, Klabunde T, Lawrenz MB, Hardham JM, Norris SJ, Sacchettini JC. Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi. The Journal of Biological Chemistry. 277: 21691-6. PMID 11923306 DOI: 10.1074/Jbc.M201547200  0.319
2002 Perozzo R, Kuo M, Sidhu ABS, Valiyaveettil JT, Bittman R, Jacobs WR, Fidock DA, Sacchettini JC. Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase Journal of Biological Chemistry. 277: 13106-13114. PMID 11792710 DOI: 10.1074/Jbc.M112000200  0.82
2002 Huang CC, Smith CV, Glickman MS, Jacobs WR, Sacchettini JC. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 277: 11559-69. PMID 11756461 DOI: 10.1074/Jbc.M111698200  0.47
2002 Yang D, Shipman LW, Roessner CA, Scott AI, Sacchettini JC. Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily. The Journal of Biological Chemistry. 277: 9462-7. PMID 11751891 DOI: 10.1074/Jbc.M110787200  0.792
2001 Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry. 40: 11442-52. PMID 11560492 DOI: 10.1021/Bi011194D  0.367
2001 Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC. Crystal structure of precorrin-8x methyl mutase. Structure (London, England : 1993). 9: 587-96. PMID 11470433 DOI: 10.1016/S0969-2126(01)00618-9  0.774
2001 Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Höök M, Sacchettini JC. Crystal Structure of Lyme Disease Antigen Outer Surface Protein C from Borrelia burgdorferi Journal of Biological Chemistry. 276: 10010-10015. PMID 11139584 DOI: 10.1074/Jbc.M010062200  0.331
2000 Sacchettini JC, Ronning DR. The mycobacterial antigens 85 complex--from structure to function: response. Trends in Microbiology. 8: 441. PMID 11203233 DOI: 10.1016/S0966-842X(00)01843-6  0.685
2000 McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR, Russell DG. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 406: 735-8. PMID 10963599 DOI: 10.1038/35021074  0.327
2000 Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR, Sacchettini JC. Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nature Structural Biology. 7: 663-8. PMID 10932251 DOI: 10.1038/77964  0.449
2000 Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR. Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis. Journal of Bacteriology. 182: 4059-4067. PMID 10869086 DOI: 10.1128/Jb.182.14.4059-4067.2000  0.785
2000 Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. The Journal of Biological Chemistry. 275: 27045-54. PMID 10854433 DOI: 10.1074/Jbc.M003001200  0.315
2000 Holton T, Ioerger TR, Christopher JA, Sacchettini JC. Determining protein structure from electron-density maps using pattern matching Acta Crystallographica Section D: Biological Crystallography. 56: 722-734. PMID 10818349 DOI: 10.1107/S0907444900003450  0.31
2000 Lücke C, Zhang F, Hamilton JA, Sacchettini JC, Rüterjans H. Solution structure of ileal lipid binding protein in complex with glycocholate. European Journal of Biochemistry. 267: 2929-38. PMID 10806391 DOI: 10.1046/J.1432-1327.2000.01307.X  0.393
2000 Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Rational design of potent human transthyretin amyloid disease inhibitors. Nature Structural Biology. 7: 312-21. PMID 10742177 DOI: 10.1038/74082  0.365
2000 Wolfrum C, Börchers T, Sacchettini JC, Spener F. Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver. Biochemistry. 39: 14363-14363. PMID 10684629 DOI: 10.1021/Bi991638U  0.32
2000 Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC. Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nature Structural Biology. 7: 141-6. PMID 10655617 DOI: 10.1038/72413  0.72
2000 O'Hagan RC, Schreiber-Agus N, Chen K, David G, Engelman JA, Schwab R, Alland L, Thomson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nature Genetics. 24: 113-9. PMID 10655054 DOI: 10.1038/72761  0.646
1999 Eicken C, Krebs B, Sacchettini JC. Catechol oxidase - structure and activity. Current Opinion in Structural Biology. 9: 677-83. PMID 10607672 DOI: 10.1016/S0959-440X(99)00029-9  0.389
1999 Kurokawa H, Dewan JC, Mikami B, Sacchettini JC, Hirose M. Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron. Journal of Biological Chemistry. 274: 28445-28452. PMID 10497206 DOI: 10.1074/Jbc.274.40.28445  0.309
1999 Balendiran GK, Molina JA, Xu Y, Torres-Martinez J, Stevens R, Focia PJ, Eakin AE, Sacchettini JC, Craig SP. Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Science : a Publication of the Protein Society. 8: 1023-31. PMID 10338013 DOI: 10.1110/Ps.8.5.1023  0.403
1999 Rozwarski DA, Vilchèze C, Sugantino M, Bittman R, Sacchettini JC. Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate. The Journal of Biological Chemistry. 274: 15582-9. PMID 10336454 DOI: 10.1074/Jbc.274.22.15582  0.395
1999 Lücke C, Fushman D, Ludwig C, Hamilton JA, Sacchettini JC, Rüterjans H. A comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart fatty acid binding protein and porcine ileal lipid binding protein. Molecular and Cellular Biochemistry. 192: 109-21. PMID 10331665 DOI: 10.1023/A:1006834708786  0.355
1999 O'Hagan R, Schreiber-Agus N, Engelman JA, Schwab R, Alland L, Thompson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. Identification of differentially regulated gene targets in the Myc and Mad family proteins Nature Genetics. 23: 66-66. DOI: 10.1038/14378  0.636
1998 Sharma V, Grubmeyer C, Sacchettini JC. Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: A potential TB drug target Structure. 6: 1587-1599. PMID 9862811 DOI: 10.1016/S0969-2126(98)00156-7  0.463
1998 Klabunde T, Eicken C, Sacchettini JC, Krebs B. Crystal structure of a plant catechol oxidase containing a dicopper center. Nature Structural Biology. 5: 1084-90. PMID 9846879 DOI: 10.1038/4193  0.324
1998 Rozwarski DA, Swami BM, Brewer CF, Sacchettini JC. Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates. Journal of Biological Chemistry. 273: 32818-32825. PMID 9830028 DOI: 10.1074/Jbc.273.49.32818  0.365
1998 Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology. 144: 2697-2704. PMID 9802011 DOI: 10.1099/00221287-144-10-2697  0.383
1998 Lim K, Owens SM, Arnold L, Sacchettini JC, Linthicum DS. Crystal structure of monoclonal 6B5 fab complexed with phencyclidine Journal of Biological Chemistry. 273: 28576-28582. PMID 9786848 DOI: 10.1074/Jbc.273.44.28576  0.355
1998 Degano M, Almo SC, Sacchettini JC, Schramm VL. Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor Biochemistry. 37: 6277-6285. PMID 9572842 DOI: 10.1021/Bi973012E  0.351
1998 Klabunde T, Sharma S, Telenti A, Jacobs WR, Sacchettini JC. Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing. Nature Structural & Molecular Biology. 5: 31-36. PMID 9437427 DOI: 10.1038/Nsb0198-31  0.4
1998 Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, Liu J, Hussey RE, Chishti Y, Thomson CT, Sweet RM, Nathenson SG, Chang HC, Sacchettini JC, Reinherz EL. Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. The Embo Journal. 17: 10-26. PMID 9427737 DOI: 10.1093/Emboj/17.1.10  0.311
1998 Rozwarski DA, Grant GA, Barton DH, Jacobs WR, Sacchettini JC. Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis. Science (New York, N.Y.). 279: 98-102. PMID 9417034 DOI: 10.1126/Science.279.5347.98  0.424
1997 Olsen LR, Dessen A, Gupta D, Sabesan S, Sacchettini JC, Brewer CF. X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin. Biochemistry. 36: 15073-15080. PMID 9398234 DOI: 10.1021/BI971828+  0.312
1997 Sacchettini JC, Poulter CD. Creating isoprenoid diversity. Science (New York, N.Y.). 277: 1788-9. PMID 9324768 DOI: 10.1126/Science.277.5333.1788  0.319
1997 Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. Journal of Biomolecular Nmr. 9: 213-28. PMID 9204553 DOI: 10.1023/A:1018666522787  0.369
1997 Xu Y, Eads J, Sacchettini JC, Grubmeyer C. Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: Rapid phosphoribosyl transfer chemistry Biochemistry. 36: 3700-3712. PMID 9132023 DOI: 10.1021/Bi9616007  0.345
1997 Eads JC, Ozturk D, Wexler TB, Grubmeyer C, Sacchettini JC. A new function for a common fold: The crystal structure of quinolinic acid phosphoribosyltransferase Structure. 5: 47-58. PMID 9016724 DOI: 10.1016/S0969-2126(97)00165-2  0.361
1997 Lücke C, Zhang F, Rüterjans H, Hamilton JA, Sacchettini JC. Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure (London, England : 1993). 4: 785-800. PMID 8805562 DOI: 10.1016/S0969-2126(96)00086-X  0.348
1996 Irigoyen M, Kowal C, Young AC, Sacchettini JC, Diamond B. Molecular mapping of the 8.12 SLE-associated idiotype specificity at the single amino acid level. Molecular Immunology. 33: 1255-65. PMID 9129162 DOI: 10.1016/S0161-5890(96)00093-4  0.304
1996 Tarshis LC, Proteau PJ, Kellogg BA, Sacchettini JC, Poulter CD. Regulation of product chain length by isoprenyl diphosphate synthases Proceedings of the National Academy of Sciences of the United States of America. 93: 15018-15023. PMID 8986756 DOI: 10.1073/Pnas.93.26.15018  0.369
1996 Sacchettini JC, Blanchard JS. The structure and function of the isoniazid target in M. tuberculosis Research in Microbiology. 147: 36-43. PMID 8761720 DOI: 10.1016/0923-2508(96)80201-4  0.357
1996 Degano M, Gopaul DN, Scapin G, Schramm VL, Sacchettini JC. Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. Biochemistry. 35: 5971-81. PMID 8634238 DOI: 10.1021/Bi952999M  0.357
1996 Gopaul DN, Meyer SL, Degano M, Sacchettini JC, Schramm VL. Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue. Biochemistry. 35: 5963-70. PMID 8634237 DOI: 10.1021/Bi952998U  0.383
1996 Baier LJ, Bogardus C, Sacchettini JC. A Polymorphism in the Human Intestinal Fatty Acid Binding Protein Alters Fatty Acid Transport across Caco-2 Cells Journal of Biological Chemistry. 271: 10892-10896. PMID 8631905 DOI: 10.1074/Jbc.271.18.10892  0.311
1995 Scapin G, Blanchard JS, Sacchettini JC. Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase. Biochemistry. 34: 3502-12. PMID 7893645 DOI: 10.1021/Bi00011A003  0.417
1995 Dessen A, Quémard A, Blanchard JS, Jacobs WR, Sacchettini JC. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis Science. 267: 1638-1641. PMID 7886450 DOI: 10.1126/Science.7886450  0.448
1995 Dessen A, Gupta D, Sabesan S, Brewer CF, Sacchettini JC. X-ray Crystal Structure of the Soybean Agglutinin Cross-Linked with a Biantennary Analog of the Blood Group I Carbohydrate Antigen Biochemistry. 34: 4933-4942. PMID 7711015 DOI: 10.1021/Bi00015A004  0.378
1995 Ozturk DH, Dorfman RH, Scapin G, Sacchettini JC, Grubmeyer C. Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: Protein complementation reveals shared active sites Biochemistry. 34: 10764-10770. PMID 7545006 DOI: 10.1021/Bi00034A008  0.351
1995 Ozturk DH, Dorfman RH, Scapin G, Sacchettini JC, Grubmeyer C. Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase Biochemistry. 34: 10755-10763. PMID 7545005 DOI: 10.1021/Bi00034A007  0.334
1995 Scapin G, Ozturk DH, Grubmeyer C, Sacchettini JC. The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and α-D-5-phosphoribosyl-1-pyrophosphate Biochemistry. 34: 10744-10754. PMID 7545004 DOI: 10.1021/Bi00034A006  0.393
1994 Scapin G, Grubmeyer C, Sacchettini JC. Crystal structure of orotate phosphoribosyltransferase Biochemistry. 33: 1287-1294. PMID 8312245 DOI: 10.1021/Bi00172A001  0.391
1994 Maatman RG, Degano M, Van Moerkerk HT, Van Marrewijk WJ, Van der Horst DJ, Sacchettini JC, Veerkamp JH. Primary structure and binding characteristics of locust and human muscle fatty-acid-binding proteins. European Journal of Biochemistry / Febs. 221: 801-10. PMID 8174560 DOI: 10.1111/J.1432-1033.1994.Tb18794.X  0.344
1994 Tarshis LC, Yan M, Poulter CD, Sacchettini JC. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-Å resolution Biochemistry. 33: 10871-10877. PMID 8086404 DOI: 10.1021/Bi00202A004  0.427
1994 Eads JC, Scapin G, Xu Y, Grubmeyer C, Sacchettini JC. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP Cell. 78: 325-334. PMID 8044844 DOI: 10.1016/0092-8674(94)90301-8  0.413
1994 Dewan JC, Grant GA, Sacchettini JC. Crystal structure of kappa-bungarotoxin at 2.3-A resolution. Biochemistry. 33: 13147-13154. PMID 7947721 DOI: 10.1021/Bi00248A026  0.371
1994 Young AC, Scapin G, Kromminga A, Patel SB, Veerkamp JH, Sacchettini JC. Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids. Structure (London, England : 1993). 2: 523-34. PMID 7922029 DOI: 10.1016/S0969-2126(00)00052-6  0.357
1994 Zanotti G, Scapin G, Spadon P, Veerkamp JH, Sacchettini JC. Three-dimensional structure of recombinant human muscle fatty acid-binding protein. Journal of Biological Chemistry. 267: 18541-18550. PMID 1526991 DOI: 10.2210/Pdb2Hmb/Pdb  0.352
1994 Eads JC, Sacchettini JC, Kromminga A, Gordon JI. Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution. Journal of Biological Chemistry. 268: 26375-26385. DOI: 10.2210/Pdb1Icm/Pdb  0.334
1994 Mikami B, Degano M, Hehre EJ, Sacchettini JC. Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis. Biochemistry. 33: 7779-7787. DOI: 10.2210/Pdb1Bya/Pdb  0.365
1993 Scapin G, Sacchettini JC, Dessen A, Bhatia M, Grubmeyer C. Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium Journal of Molecular Biology. 230: 1304-1308. PMID 8487307 DOI: 10.1006/Jmbi.1993.1244  0.354
1993 Scapin G, Young AC, Kromminga A, Veerkamp JH, Gordon JI, Sacchettini JC. High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions. Molecular and Cellular Biochemistry. 123: 3-13. PMID 8232266 DOI: 10.1007/Bf01076469  0.35
1993 Dewan JC, Mikami B, Hirose M, Sacchettini JC. Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release. Biochemistry. 32: 11963-11968. PMID 8218271 DOI: 10.1021/Bi00096A004  0.315
1992 Scapin G, Gordon JI, Sacchettini JC. Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution. The Journal of Biological Chemistry. 267: 4253-69. PMID 1740465 DOI: 10.2210/Pdb1Ifc/Pdb  0.382
1992 Green RP, Cohn SM, Sacchettini JC, Jackson KE, Gordon JI. The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product. Dna and Cell Biology. 11: 31-41. PMID 1739433 DOI: 10.1089/Dna.1992.11.31  0.319
1991 Gordon JI, Sacchettini JC, Ropson IJ, Frieden C, Li E, Rubin DC, Roth KA, Cistola DP. Intracellular fatty-acid-binding proteins and their genes: Useful models for diverse biological questions Current Opinion in Lipidology. 2: 125-137. DOI: 10.1097/00041433-199104000-00011  0.317
1990 Sacchettini JC, Banaszak LJ, Gordon JI. Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction. Molecular and Cellular Biochemistry. 98: 81-93. PMID 2266973 DOI: 10.1007/Bf00231371  0.382
1990 Cistola DP, Sacchettini JC, Gordon JI. 13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium Molecular and Cellular Biochemistry. 98: 101-110. PMID 2266951 DOI: 10.1007/Bf00231373  0.378
1989 Sacchettini JC, Gordon JI, Banaszak LJ. Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 86: 7736-40. PMID 2682622 DOI: 10.1073/Pnas.86.20.7736  0.365
1989 Sacchettini JC, Gordon JI, Banaszak LJ. Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate. Journal of Molecular Biology. 208: 327-39. PMID 2671390 DOI: 10.1016/0022-2836(89)90392-6  0.378
1988 Sacchettini JC, Frazier MW, Chiara DC, Banaszak LJ, Grant GA. Amino acid sequence of porcine heart fumarase. Biochemical and Biophysical Research Communications. 153: 435-40. PMID 3377794 DOI: 10.1016/S0006-291X(88)81243-9  0.321
1983 Grant GA, Sacchettini JC, Welgus HG. A collagenolytic serine protease with trypsin-like specificity from the fiddler crab Uca pugilator Biochemistry. 22: 354-358. PMID 6337626 DOI: 10.1021/Bi00271A019  0.356
Low-probability matches (unlikely to be authored by this person)
1998 Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 95: 12956-60. PMID 9789022 DOI: 10.1073/Pnas.95.22.12956  0.294
2019 Dixit A, Freschi L, Vargas R, Calderon R, Sacchettini J, Drobniewski F, Galea JT, Contreras C, Yataco R, Zhang Z, Lecca L, Kolokotronis SO, Mathema B, Farhat MR. Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting. Scientific Reports. 9: 5602. PMID 30944370 DOI: 10.1038/S41598-019-41967-8  0.294
2012 Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. Plos Pathogens. 8: e1002946. PMID 23028335 DOI: 10.1371/Journal.Ppat.1002946  0.294
1984 Birktoft JJ, Banaszak LJ, Holden HM, Ross J, Roderick SL, Sacchettini J, Hamlin RC, Xoung N. L-3-Hydroxyacyl coenzyme-A dehydrogenase – structural studies at 3.5 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 40: C30-C30. DOI: 10.1107/S0108767384098901  0.293
2006 Romo TD, Sacchettini JC, Ioerger TR. Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building. Acta Crystallographica. Section D, Biological Crystallography. 62: 1401-6. PMID 17057345 DOI: 10.1107/S0907444906034019  0.293
2013 Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 155: 1296-308. PMID 24315099 DOI: 10.1016/J.Cell.2013.10.045  0.292
2018 Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T. Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis. Bmc Research Notes. 11: 416. PMID 29954459 DOI: 10.1186/S13104-018-3526-Z  0.292
2018 Ganley J, Carr G, Ioerger T, Sacchettini J, Clardy J, Derbyshire E. Discovery of antimicrobial lipodepsipeptides produced by a Serratia sp. within mosquito microbiomes. Chembiochem : a European Journal of Chemical Biology. PMID 29700993 DOI: 10.1002/Cbic.201800124  0.292
1993 Mikami B, Hehre EJ, Sato M, Katsube Y, Hirose M, Morita Y, Sacchettini JC. The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin. Biochemistry. 32: 6836-6845. PMID 8334116 DOI: 10.1021/Bi00078A006  0.291
1997 Liu J, Tse AG, Chang HC, Liu Jh, Wang J, Hussey RE, Chishti Y, Rheinhold B, Spoerl R, Nathenson SG, Sacchettini JC, Reinherz EL. Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment. The Journal of Biological Chemistry. 271: 33639-46. PMID 8969233 DOI: 10.1074/Jbc.271.52.33639  0.291
2008 Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, ... ... Sacchettini JC, et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host & Microbe. 4: 567-78. PMID 19064257 DOI: 10.1016/J.Chom.2008.11.001  0.291
2009 Sun Q, Kuty GF, Arockiasamy A, Xu M, Young R, Sacchettini JC. Regulation of a muralytic enzyme by dynamic membrane topology. Nature Structural & Molecular Biology. 16: 1192-4. PMID 19881499 DOI: 10.1038/Nsmb.1681  0.291
2021 Black KA, Duan L, Mandyoli L, Selbach BP, Xu W, Ehrt S, Sacchettini JC, Rhee KY. Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. The Journal of Experimental Medicine. 218. PMID 33950161 DOI: 10.1084/jem.20191957  0.291
2003 Reddy V, Swanson SM, Segelke B, Kantardjieff KA, Sacchettini JC, Rupp B. Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service. Acta Crystallographica Section D-Biological Crystallography. 59: 2200-2210. PMID 14646078 DOI: 10.1107/S0907444903020316  0.29
2018 Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM. TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. Plos Pathogens. 14: e1006939. PMID 29505613 DOI: 10.1371/Journal.Ppat.1006939  0.29
2021 Pandey S, Singh A, Yang G, d'Andrea FB, Jiang X, Hartman TE, Mosior JW, Bourland R, Gold B, Roberts J, Geiger A, Tang S, Rhee K, Ouerfelli O, Sacchettini JC, et al. Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis. Microbiology Spectrum. e0092821. PMID 34550010 DOI: 10.1128/Spectrum.00928-21  0.29
2017 Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment. Elife. 6. PMID 28220755 DOI: 10.7554/Elife.20420  0.289
2004 Adams PD, Gopal K, Grosse-Kunstleve RW, Hung LW, Ioerger TR, McCoy AJ, Moriarty NW, Pai RK, Read RJ, Romo TD, Sacchettini JC, Sauter NK, Storoni LC, Terwilliger TC. Recent developments in the PHENIX software for automated crystallographic structure determination. Journal of Synchrotron Radiation. 11: 53-5. PMID 14646133 DOI: 10.1107/S0909049503024130  0.288
2006 Romo TD, Sacchettini JC, Terwilliger TC, Adams PD, Afonine PV, Grosse-Kunstleve RW, Moriarty NW, Sauter NK, Zwart PH, Gopal K, Ioerger TR, Kanbi L, McKee E, Pai RK, Hung L, et al. Automated structure determination with phenix Acta Crystallographica Section A. 62: 101-109. DOI: 10.1007/978-1-4020-6316-9_9  0.287
2005 Xu M, Arulandu A, Struck DK, Swanson S, Sacchettini JC, Young R. Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme. Science. 307: 113-117. PMID 15637279 DOI: 10.1126/Science.1105143  0.286
2005 Gopal K, Romo TD, Sacchettini JC, Ioerger TR. Determining relevant features to recognize electron density patterns in x-ray protein crystallography. Journal of Bioinformatics and Computational Biology. 3: 645-76. PMID 16108088 DOI: 10.1142/S0219720005001272  0.285
1997 Balendiran GK, Solheim JC, Young AC, Hansen TH, Nathenson SG, Sacchettini JC. The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide. Proceedings of the National Academy of Sciences of the United States of America. 94: 6880-5. PMID 9192660 DOI: 10.1073/Pnas.94.13.6880  0.285
1992 Zhang W, Young AC, Imarai M, Nathenson SG, Sacchettini JC. Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. Proceedings of the National Academy of Sciences of the United States of America. 89: 8403-7. PMID 1325657 DOI: 10.1073/Pnas.89.17.8403  0.284
1995 Papadopoulos NJ, Sacchettini JC, Nathenson SG, Angeletti RH. Rapid in vitro assembly of class I major histocompatibility complex Techniques in Protein Chemistry. 6: 375-383. DOI: 10.1016/S1080-8914(06)80046-3  0.283
2022 Cui Z, Li X, Shin J, Gamper H, Hou YM, Sacchettini JC, Zhang J. Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nature Communications. 13: 432. PMID 35064151 DOI: 10.1038/s41467-022-28078-1  0.283
1995 Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Mochizuki H, Bennett PH, Bogardus C, Prochazka M. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. Journal of Clinical Investigation. 95: 1281-1287. PMID 7883976 DOI: 10.1172/Jci117778  0.282
2002 Ioerger TR, Sacchettini JC. Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates. Acta Crystallographica. Section D, Biological Crystallography. 58: 2043-54. PMID 12454463 DOI: 10.1107/S0907444902016724  0.282
2005 Trevino SR, Gokulan K, Newsom S, Thurlkill RL, Shaw KL, Mitkevich VA, Makarov AA, Sacchettini JC, Scholtz JM, Pace CN. Asp79 makes a large, unfavorable contribution to the stability of RNase Sa. Journal of Molecular Biology. 354: 967-78. PMID 16288913 DOI: 10.1016/J.Jmb.2005.09.091  0.281
2010 Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. Journal of Bacteriology. 192: 3645-53. PMID 20472797 DOI: 10.1128/Jb.00166-10  0.278
2014 Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL. Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing. Nature Medicine. 20: 75-9. PMID 24336248 DOI: 10.1038/Nm.3412  0.278
2011 Madina BR, Kuppan G, Vashisht AA, Liang YH, Downey KM, Wohlschlegel JA, Ji X, Sze SH, Sacchettini JC, Read LK, Cruz-Reyes J. Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei. Rna (New York, N.Y.). 17: 1821-30. PMID 21810935 DOI: 10.1261/Rna.2815911  0.277
2015 Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrobial Agents and Chemotherapy. 59: 2256-64. PMID 25645825 DOI: 10.1128/Aac.05114-14  0.276
2006 Morbidoni HR, Vilchèze C, Kremer L, Bittman R, Sacchettini JC, Jacobs WR. Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids. Chemistry & Biology. 13: 297-307. PMID 16638535 DOI: 10.1016/J.Chembiol.2006.01.005  0.276
1995 Young AC, Nathenson SG, Sacchettini JC. Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 26-36. PMID 7821756 DOI: 10.1096/Fasebj.9.1.7821756  0.276
2003 Ioerger TR, Sacchettini JC. TEXTAL system: artificial intelligence techniques for automated protein model building. Methods in Enzymology. 374: 244-70. PMID 14696377 DOI: 10.1016/S0076-6879(03)74012-9  0.275
2017 Lehmann J, Cheng T, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA. Ein antibakterielles β-Lacton bekämpft Mycobacterium tuberculosis durch Infiltration der Mykolsäurebiosynthese Angewandte Chemie. 130: 354-359. DOI: 10.1002/Ange.201709365  0.275
2005 McKee EW, Kanbi LD, Childs KL, Grosse-Kunstleve RW, Adams PD, Sacchettini JC, Ioerger TR. FINDMOL: Automated identification of macromolecules in electron-density maps Acta Crystallographica Section D: Biological Crystallography. 61: 1514-1520. PMID 16239729 DOI: 10.1107/S0907444905027332  0.274
2023 Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, ... ... Sacchettini JC, et al. Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell. PMID 36827973 DOI: 10.1016/j.cell.2023.01.043  0.273
2019 Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M. Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness. Scientific Reports. 9: 11394. PMID 31388080 DOI: 10.1038/S41598-019-47905-Y  0.271
1994 Young AC, Zhang W, Sacchettini JC, Nathenson SG. The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection. Cell. 76: 39-50. PMID 7506996 DOI: 10.1016/0092-8674(94)90171-6  0.27
2008 Chinnaswamy S, Yarbrough I, Palaninathan S, Kumar CT, Vijayaraghavan V, Demeler B, Lemon SM, Sacchettini JC, Kao CC. A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase. The Journal of Biological Chemistry. 283: 20535-46. PMID 18442978 DOI: 10.1074/Jbc.M801490200  0.269
2019 Chen Q, Shah KN, Zhang F, Salazar AJ, Shah PN, Li R, Sacchettini JC, Wooley KL, Cannon CL. Minocycline and silver dual-loaded polyphosphoester-based nanoparticles for treatment of resistant Pseudomonas aeruginosa. Molecular Pharmaceutics. PMID 30817887 DOI: 10.1021/Acs.Molpharmaceut.8B01288  0.269
2007 Kang H, Bhardwaj K, Li Y, Palaninathan S, Sacchettini J, Guarino L, Leibowitz JL, Kao CC. Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease. Journal of Virology. 81: 13587-97. PMID 17898055 DOI: 10.1128/Jvi.00547-07  0.266
2015 Wallis D, Loesch K, Galaviz S, Sun Q, DeJesus M, Ioerger T, Sacchettini JC. High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection. Stem Cells (Dayton, Ohio). 33: 2509-22. PMID 25752821 DOI: 10.1002/Stem.1983  0.264
2015 Harshbarger W, Miller C, Diedrich C, Sacchettini J. Crystal structure of the human 20S proteasome in complex with carfilzomib. Structure (London, England : 1993). 23: 418-24. PMID 25599644 DOI: 10.1016/j.str.2014.11.017  0.263
2018 Daniel-Wayman S, Abate G, Barber DL, Bermudez LE, Coler RN, Cynamon MH, Daley CL, Davidson RM, Dick T, Floto RA, Henkle E, Holland SM, Jackson M, Lee RE, Nuermberger EL, ... ... Sacchettini JC, et al. Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research. American Journal of Respiratory and Critical Care Medicine. PMID 30428263 DOI: 10.1164/Rccm.201807-1273Pp  0.262
2003 Takano K, Scholtz JM, Sacchettini JC, Pace CN. The contribution of polar group burial to protein stability is strongly context-dependent. The Journal of Biological Chemistry. 278: 31790-5. PMID 12799387 DOI: 10.1074/Jbc.M304177200  0.261
1997 Young AC, Valadon P, Casadevall A, Scharff MD, Sacchettini JC. The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes. Journal of Molecular Biology. 274: 622-34. PMID 9417940 DOI: 10.1006/Jmbi.1997.1407  0.256
2014 Shi X, Festa RA, Ioerger TR, Butler-Wu S, Sacchettini JC, Darwin KH, Samanovic MI. The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence. Mbio. 5. PMID 24549843 DOI: 10.7490/F1000Research.1095241.1  0.256
2013 Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Correction: Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis Plos Pathogens. 9. DOI: 10.1371/Annotation/4669E9E7-Fd12-4A01-Be2A-617B956Ec0Bb  0.255
2006 Gaffin RD, Gokulan K, Sacchettini JC, Hewett TE, Klevitsky R, Robbins J, Sarin V, Zawieja DC, Meininger GA, Muthuchamy M. Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics. American Journal of Physiology. Heart and Circulatory Physiology. 291: H552-63. PMID 16501024 DOI: 10.1152/Ajpheart.00688.2005  0.255
2000 Holmes JH, Lieberman JM, Marks WH, Probert CB, Hill ME, Paull DL, Guyton SW, Sacchettini J, Hall RA. Cardiopulmonary bypass, mesenteric perfusion, & small intestinal epithelial integrity: preliminary analysis using a novel protein marker Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)86348-9  0.254
2015 Lanoix JP, Ioerger T, Ormond A, Kaya F, Sacchettini J, Dartois V, Nuermberger E. Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum. Antimicrobial Agents and Chemotherapy. 60: 735-43. PMID 26574016 DOI: 10.1128/Aac.01370-15  0.253
2020 Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet J, Arthur M, Sacchettini JC, et al. Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases Frontiers in Microbiology. 11. DOI: 10.3389/fmicb.2020.01248  0.253
2023 Ottavi S, Li K, Cacioppo JG, Perkowski AJ, Ramesh R, Gold BS, Ling Y, Roberts J, Singh A, Zhang D, Mosior J, Goullieux L, Roubert C, Bacqué E, Sacchettini JC, et al. PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas. Acs Medicinal Chemistry Letters. 14: 970-976. PMID 37465309 DOI: 10.1021/acsmedchemlett.3c00162  0.251
2001 Thomson CT, Kalergis AM, Sacchettini JC, Nathenson SG. A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction. Journal of Immunology (Baltimore, Md. : 1950). 166: 3994-7. PMID 11238645 DOI: 10.4049/Jimmunol.166.6.3994  0.249
2007 Gopal K, Sacchettini JC, Joerger TR. Database approaches and data representation in structural bioinformatics Proceedings of the 7th Ieee International Conference On Bioinformatics and Bioengineering, Bibe. 425-432. DOI: 10.1109/BIBE.2007.4375597  0.247
2003 Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW. Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action. Angewandte Chemie (International Ed. in English). 42: 2758-61. PMID 12820260 DOI: 10.1002/Anie.200351179  0.247
2017 Perkowski EF, Zulauf KE, Weerakoon D, Hayden JD, Ioerger TR, Oreper D, Gomez SM, Sacchettini JC, Braunstein M. Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection". Mbio. 8. PMID 28634243 DOI: 10.1128/Mbio.00872-17  0.246
2005 Gao T, Zhang X, Xia Y, Cho Y, Sacchettini JC, Golden SS, Liwang AC. 1H, 13C and 15N chemical shift assignments of the C-terminal, 133-residue pseudo-receiver domain of circadian input kinase (CikA) in Synechococcus elongatus. Journal of Biomolecular Nmr. 32: 259. PMID 16132830 DOI: 10.1007/S10858-005-7945-5  0.246
2015 Li X, Sun Q, Jiang C, Yang K, Hung LW, Zhang J, Sacchettini JC. Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome. Structure (London, England : 1993). 23: 2387. PMID 29673486 DOI: 10.1016/j.str.2015.11.002  0.245
2002 Deaton J, Savva C, Sun J, Sharma S, Holzenburg A, Sacchettini J, Young R. GroEL: A Proteinaceous “Surfactant” ? Microscopy and Microanalysis. 8: 840-841. DOI: 10.1017/S1431927602102558  0.245
2013 DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics (Oxford, England). 29: 695-703. PMID 23361328 DOI: 10.1093/Bioinformatics/Btt043  0.244
2021 Pham TV, Mellott DM, Moghadamchargari Z, Chen K, Krieger I, Laganowsky A, Sacchettini JC, Meek TD. Covalent Inactivation of Isocitrate Lyase by -2,3-Epoxy-Succinic Acid. Acs Chemical Biology. PMID 33688722 DOI: 10.1021/acschembio.0c00740  0.244
2015 Loesch K, Galaviz S, Hamoui Z, Clanton R, Akabani G, Deveau M, DeJesus M, Ioerger T, Sacchettini JC, Wallis D. Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes. Plos One. 10: e0120534. PMID 25853515 DOI: 10.1371/Journal.Pone.0120534  0.243
2006 Pai R, Sacchettini J, Ioerger T. Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach. Acta Crystallographica. Section D, Biological Crystallography. 62: 1012-21. PMID 16929102 DOI: 10.1107/S0907444906023158  0.243
1997 Lieberman JM, Sacchettini J, Marks C, Marks WH. Human intestinal fatty acid binding protein: Report of an assay with studies in normal volunteers and intestinal ischemia Surgery. 121: 335-342. PMID 9068676 DOI: 10.1016/S0039-6060(97)90363-9  0.242
2022 Katti SS, Krieger IV, Ann J, Lee J, Sacchettini JC, Igumenova TI. Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists. Nature Communications. 13: 2695. PMID 35577811 DOI: 10.1038/s41467-022-30389-2  0.239
2021 Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, ... ... Sacchettini JC, et al. Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. Journal of Medicinal Chemistry. PMID 34910486 DOI: 10.1021/acs.jmedchem.1c01586  0.238
2017 Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT. Author response: Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment Elife. DOI: 10.7554/Elife.20420.025  0.238
1998 Lieberman JM, Marks WH, Cohn S, Jaicks R, Woode L, Sacchettini J, Fischer B, Moller B, Burns G. Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: study of 100 consecutive patients in a surgical intensive care unit. Journal of Trauma-Injury Infection and Critical Care. 45: 900-906. PMID 9820701 DOI: 10.1097/00005373-199811000-00011  0.237
2001 Holmes JH, Lieberman JM, Probert CB, Marks WH, Hill ME, Paull DL, Guyton SW, Sacchettini J, Hall RA. Elevated intestinal fatty acid binding protein and gastrointestinal complications following cardiopulmonary bypass: a preliminary analysis. The Journal of Surgical Research. 100: 192-6. PMID 11592792 DOI: 10.1006/Jsre.2001.6237  0.236
2008 Pai R, Sacchettini JC, Ioerger TR. Analysis of protein-ligand interactions using localized stereochemical features Proceedings of the 2008 International Conference On Bioinformatics and Computational Biology, Biocomp 2008. 666-673.  0.234
2022 Kreutzfeldt KM, Jansen RS, Hartman TE, Gouzy A, Wang R, Krieger IV, Zimmerman MD, Gengenbacher M, Sarathy JP, Xie M, Dartois V, Sacchettini JC, Rhee KY, Schnappinger D, Ehrt S. CinA mediates multidrug tolerance in Mycobacterium tuberculosis. Nature Communications. 13: 2203. PMID 35459278 DOI: 10.1038/s41467-022-29832-1  0.233
2004 Gaffin RD, Gokulan K, Sacchettini JC, Hewett T, Klevitsky R, Robbins J, Muthuchamy M. Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility. The Journal of Physiology. 556: 531-43. PMID 14766940 DOI: 10.1113/Jphysiol.2003.058487  0.233
2023 Guo T, Sperber AM, Krieger IV, Duan Y, Chemelewski VR, Sacchettini JC, Herman JK. YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization. Journal of Bacteriology. e0020223. PMID 38047707 DOI: 10.1128/jb.00202-23  0.223
2022 Ottavi S, Scarry SM, Mosior J, Ling Y, Roberts J, Singh A, Zhang D, Goullieux L, Roubert C, Bacqué E, Lagiakos HR, Vendome J, Moraca F, Li K, Perkowski AJ, ... ... Sacchettini JC, et al. In Vitro and In Vivo Inhibition of the Phosphopantetheinyl Transferase PptT by Amidinoureas. Journal of Medicinal Chemistry. PMID 35044775 DOI: 10.1021/acs.jmedchem.1c01565  0.218
2020 Guthrie LM, Soma S, Yuan S, Silva A, Zulkifli M, Snavely TC, Greene HF, Nunez E, Lynch B, De Ville C, Shanbhag V, Lopez FR, Acharya A, Petris MJ, Kim BE, ... ... Sacchettini JC, et al. Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Science (New York, N.Y.). 368: 620-625. PMID 32381719 DOI: 10.1126/Science.Aaz8899  0.215
2021 Mellott DM, Torres D, Krieger IV, Cameron SA, Moghadamchargari Z, Laganowsky A, Sacchettini JC, Meek TD, Harris LD. Mechanism-Based Inactivation of Isocitrate Lyase 1 by (2,3)-2-Hydroxy-3-(nitromethyl)succinic acid. Journal of the American Chemical Society. 143: 17666-17676. PMID 34664502 DOI: 10.1021/jacs.1c07970  0.211
2018 Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER. Front Cover: Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes (ChemBioChem 15/2018) Chembiochem. 19: 1570-1570. DOI: 10.1002/Cbic.201800362  0.209
2002 Sacchettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nature Reviews. Drug Discovery. 1: 267-75. PMID 12120278 DOI: 10.1038/Nrd769  0.208
2003 Savva C, Arulandu S, Sacchettini J, Holzenburg A. Electron Microscopy and Single Particle Analysis of a Mycobacterial Preprotein Translocation ATPase Microscopy and Microanalysis. 9: 1364-1365. DOI: 10.1017/S1431927603446825  0.208
2020 Ingram SN, Robbins AB, Gillenwater SJ, Gresham V, Sacchettini JC, Moreno MR. A low-cost, novel endoscopic repeated-access port for small animal research. Methodsx. 7: 101049. PMID 32944515 DOI: 10.1016/J.Mex.2020.101049  0.204
2021 Truong DP, Rousseau S, Machala BW, Huddleston JP, Zhu M, Hull KG, Romo D, Raushel FM, Sacchettini JC, Glasner ME. Second-Shell Amino Acid R266 Helps Determine -Succinylamino Acid Racemase Reaction Specificity in Promiscuous -Succinylamino Acid Racemase/-Succinylbenzoate Synthase Enzymes. Biochemistry. PMID 34845903 DOI: 10.1021/acs.biochem.1c00627  0.203
2020 Mackenzie JS, Lamprecht DA, Asmal R, Adamson JH, Borah K, Beste DJV, Lee BS, Pethe K, Rousseau S, Krieger I, Sacchettini JC, Glasgow JN, Steyn AJC. Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis. Nature Communications. 11: 6092. PMID 33257709 DOI: 10.1038/s41467-020-19959-4  0.171
2020 Rifat D, Li SY, Ioerger T, Shah K, Lanoix JP, Lee J, Bashiri G, Sacchettini J, Nuermberger E. Mutations in () as a novel determinant of resistance to pretomanid and delamanid in . Antimicrobial Agents and Chemotherapy. PMID 33077652 DOI: 10.1128/AAC.01948-20  0.167
2008 Pai R, Sacchettini JC, Ioerger TR. Specificity normalization for identifying selective inhibitors in virtual screening Proceedings of the 2008 International Conference On Bioinformatics and Computational Biology, Biocomp 2008. 787-793.  0.165
2020 Burke C, Jankute M, Moynihan P, Gonzalez Del Rio R, Li X, Esquivias J, Lelièvre J, Cox JAG, Sacchettini J, Besra GS. Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline. Faseb Bioadvances. 2: 600-612. PMID 33089076 DOI: 10.1096/fba.2020-00022  0.16
2023 Rath S, Panda S, Sacchettini JC, Berthel SJ. DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery. Acs Pharmacology & Translational Science. 6: 1043-1051. PMID 37470023 DOI: 10.1021/acsptsci.3c00034  0.14
2021 Aldridge BB, Barros-Aguirre D, Barry CE, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, ... ... Sacchettini JC, et al. The Tuberculosis Drug Accelerator at year 10: what have we learned? Nature Medicine. PMID 34226736 DOI: 10.1038/s41591-021-01442-2  0.135
2019 Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM. Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. Plos Pathogens. 15: e1007846. PMID 31163081 DOI: 10.1371/journal.ppat.1007846  0.131
2021 Wang H, Conover GM, Han SI, Sacchettini JC, Han A. Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of . Microsystems & Nanoengineering. 7: 37. PMID 34567751 DOI: 10.1038/s41378-021-00262-1  0.124
2011 Lotesta SD, Liu J, Yates EV, Krieger I, Sacchettini JC, Freundlich JS, Sorensen EJ. Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis Chemical Science. 2: 1258-1261. DOI: 10.1039/c1sc00116g  0.089
2022 Gordon PD, De Ville C, Sacchettini JC, Coté GL. A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears. Plos One. 17: e0266441. PMID 35390054 DOI: 10.1371/journal.pone.0266441  0.074
2004 Gopal K, Romo TD, Sacchettini JC, Ioerger TR. Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography. Proceedings / Ieee Computational Systems Bioinformatics Conference, Csb. Ieee Computational Systems Bioinformatics Conference. 255-65. PMID 16448019  0.069
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