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David L. Roman, Ph.D. - Publications

Affiliations: 
1998-2004 Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
 2004-2008 Pharmacology University of Michigan Medical School Ann Arbor 
 2008- Pharmaceutical Sciences & Experimental Therapeutics University of Iowa, Iowa City, IA 
Area:
RGS Proteins, Drug Discovery & HTS
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA, ... ... Roman DL, et al. The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. British Journal of Pharmacology. S1-S22. PMID 38123153 DOI: 10.1111/bph.16176  0.793
2022 Dwyer TS, O'Brien JB, Ptak CP, LaVigne JE, Flaherty DP, Watts VJ, Roman DL. Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype. Frontiers in Pharmacology. 13: 977742. PMID 36147328 DOI: 10.3389/fphar.2022.977742  0.684
2021 Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, ... ... Roman DL, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. British Journal of Pharmacology. 178: S1-S26. PMID 34529830 DOI: 10.1111/bph.15537  0.793
2021 O'Brien JB, Roman DL. Novel treatments for chronic pain: moving beyond opioids. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 33727192 DOI: 10.1016/j.trsl.2021.03.008  0.569
2021 Hayes MP, O'Brien J, Fowler CA, Yu L, Roman DL, Crawford R, Doorn JA. Fragment-based nuclear magnetic resonance screen against a Regulator of G Protein Signaling identifies a binding "hot spot". Chembiochem : a European Journal of Chemical Biology. PMID 33480159 DOI: 10.1002/cbic.202000740  0.802
2020 Ahlers-Dannen KE, Alqinyah M, Bodle C, Bou Dagher J, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Lee J, Luo Z, ... ... Roman DL, et al. Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2020. DOI: 10.2218/gtopdb/f891/2020.5  0.833
2020 Ahlers-Dannen KE, Alqinyah M, Bodle C, Bou Dagher J, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Lee J, Luo Z, ... ... Roman DL, et al. Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2020. DOI: 10.2218/gtopdb/f891/2020.4  0.833
2020 O’Brien J, Hayes M, Watts V, Roman D. Approaches to Targeting Adenylyl Cyclase 1 for Novel Pain Therapeutics The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05454  0.58
2019 O'Brien JB, Wilkinson JC, Roman DL. Regulator of G protein signaling (RGS) proteins as drug targets: Progress and future potentials. The Journal of Biological Chemistry. PMID 31636120 DOI: 10.1074/Jbc.Rev119.007060  0.82
2019 Sieng M, Hayes MP, O'Brien JB, Fowler CA, Houtman JC, Roman DL, Lyon AM. High-resolution structure of RGS17 suggests a role for Ca2+ in promoting the GTPase activating protein activity by RZ subfamily members. The Journal of Biological Chemistry. PMID 30940727 DOI: 10.1074/Jbc.Ra118.006059  0.779
2019 Alqinyah M, Bodle C, Bou Dagher J, Chakravarti B, Choudhuri SP, Druey KM, Fisher RA, Gerber KJ, Hepler JR, Hooks SB, Kantheti HS, Karaj B, Lee J, Luo Z, Martemyanov K, ... ... Roman DL, et al. Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f891/2019.4  0.835
2018 Bodle CR, Schamp JH, O'Brien JB, Hayes MP, Wu M, Doorn JA, Roman DL. Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. Slas Discovery : Advancing Life Sciences R & D. 2472555217752301. PMID 29351497 DOI: 10.1177/2472555217752301  0.832
2017 Hayes MP, Bodle CR, Roman DL. Evaluation of the Selectivity and Cysteine-Dependence of Inhibitors Across the Regulator of G Protein Signaling Family. Molecular Pharmacology. PMID 29051318 DOI: 10.1124/mol.117.109843  0.832
2017 Hayes MP, Soto-Velasquez M, Fowler CA, Watts VJ, Roman DL. Identification of FDA-approved small molecules capable of disrupting the Calmodulin-Adenylyl Cyclase 8 interaction through direct binding to Calmodulin. Acs Chemical Neuroscience. PMID 28968502 DOI: 10.1021/Acschemneuro.7B00349  0.616
2017 Bodle CR, Mackie DI, Hayes MP, Schamp JH, Miller MR, Henry MD, Doorn JA, Houtman JCD, James MA, Roman DL. Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. Journal of Natural Products. PMID 28621943 DOI: 10.1021/acs.jnatprod.7b00112  0.775
2017 Bodle CR, Hayes MP, O'Brien JB, Roman DL. "Development of bimolecular luminescence complementation assay for RGS: G protein interactions in cells." Analytical Biochemistry. PMID 28115169 DOI: 10.1016/j.ab.2017.01.013  0.831
2016 Hayes MP, Roman DL. Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers. The Aaps Journal. PMID 26928451 DOI: 10.1208/s12248-016-9894-1  0.716
2015 Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ. Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways. The Journal of Pharmacology and Experimental Therapeutics. 352: 480-93. PMID 25539635 DOI: 10.1124/Jpet.114.220293  0.629
2015 Brust TF, Hayes MP, Roman DL, Watts VJ. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochemical Pharmacology. 93: 85-91. PMID 25449598 DOI: 10.1016/J.Bcp.2014.10.014  0.627
2013 Zhang X, Hagen J, Muniz VP, Smith T, Coombs GS, Eischen CM, Mackie DI, Roman DL, Van Rheeden R, Darbro B, Tompkins VS, Quelle DE. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. Plos One. 8: e80228. PMID 24282525 DOI: 10.1371/Journal.Pone.0080228  0.773
2013 Monroy CA, Doorn JA, Roman DL. Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 26: 1832-9. PMID 24229325 DOI: 10.1021/Tx400212Q  0.811
2013 Bodle CR, Mackie DI, Roman DL. RGS17: an emerging therapeutic target for lung and prostate cancers. Future Medicinal Chemistry. 5: 995-1007. PMID 23734683 DOI: 10.4155/Fmc.13.91  0.815
2013 Monroy CA, Mackie DI, Roman DL. A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation. Plos One. 8: e62247. PMID 23626793 DOI: 10.1371/Journal.Pone.0062247  0.814
2013 Vermeer LM, Higgins CA, Roman DL, Doorn JA. Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical Biochemistry. 432: 11-5. PMID 23010244 DOI: 10.1016/J.Ab.2012.09.005  0.755
2013 Monroy CA, Mackie DI, Roman DL. Scheme of Malachite Green Assay. Plos One. DOI: 10.1371/Journal.Pone.0062247.G001  0.734
2012 Higgins CA, Vermeer LM, Doorn JA, Roman DL. Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein Expression and Purification. 84: 219-23. PMID 22659380 DOI: 10.1016/J.Pep.2012.05.007  0.774
2011 Roman DL, Traynor JR. Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction. Journal of Medicinal Chemistry. 54: 7433-40. PMID 21916427 DOI: 10.1021/Jm101572N  0.524
2011 Mackie DI, Roman DL. Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen. Journal of Biomolecular Screening. 16: 869-77. PMID 21680864 DOI: 10.1177/1087057111410427  0.832
2010 Blazer LL, Roman DL, Chung A, Larsen MJ, Greedy BM, Husbands SM, Neubig RR. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Molecular Pharmacology. 78: 524-33. PMID 20571077 DOI: 10.1124/Mol.110.065128  0.711
2010 Roman DL, Blazer LL, Monroy CA, Neubig RR. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Molecular Pharmacology. 78: 360-5. PMID 20530129 DOI: 10.1124/Mol.109.063388  0.829
2010 Blazer LL, Roman DL, Muxlow MR, Neubig RR. Use of flow cytometric methods to quantify protein-protein interactions. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.11.1-15. PMID 20069525 DOI: 10.1002/0471142956.Cy1311S51  0.655
2010 Talbot JN, Roman DL, Clark MJ, Roof RA, Tesmer JJ, Neubig RR, Traynor JR. Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. Journal of Neurochemistry. 112: 1026-34. PMID 20002516 DOI: 10.1111/J.1471-4159.2009.06519.X  0.65
2009 Roman DL. Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential. Progress in Molecular Biology and Translational Science. 86: 335-56. PMID 20374721 DOI: 10.1016/S1877-1173(09)86011-0  0.577
2009 Roman DL, Ota S, Neubig RR. Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors. Journal of Biomolecular Screening. 14: 610-9. PMID 19531661 DOI: 10.1177/1087057109336590  0.708
2009 Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9  0.643
2008 Shankaranarayanan A, Thal DM, Tesmer VM, Roman DL, Neubig RR, Kozasa T, Tesmer JJ. Assembly of high order G alpha q-effector complexes with RGS proteins. The Journal of Biological Chemistry. 283: 34923-34. PMID 18936096 DOI: 10.1074/Jbc.M805860200  0.646
2008 Bernsteel DJ, Roman DL, Neubig RR. In vitro protein kinase activity measurement by flow cytometry. Analytical Biochemistry. 383: 180-5. PMID 18796290 DOI: 10.1016/J.Ab.2008.08.026  0.548
2008 Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/J.1747-0285.2008.00687.X  0.624
2008 Pei J, Dishinger JF, Roman DL, Rungwanitcha C, Neubig RR, Kennedy RT. Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system. Analytical Chemistry. 80: 5225-31. PMID 18465881 DOI: 10.1021/Ac800553G  0.585
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/Mol.106.028670  0.73
2007 Blazer LL, Roman DL, Neubig RR. Development of a Time Resolved FRET High-Throughput Assay to Identify Inhibitors of the RGS4/G{alpha}o Interaction The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A431-D  0.355
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Characterization and mechanistic investigation of CCG‐4986, a small molecule RGS4 inhibitor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A431  0.529
2007 Talbot JN, Roman DL, Neubig RR, Traynor JR. Biphasic regulation of mu‐opioid signaling to adenylyl cyclase by GTPase accelerating protein (GAP) activity of RGS7 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A430  0.462
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/J.1747-0285.2006.00373.X  0.627
2004 Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 308: 679-87. PMID 14593087 DOI: 10.1124/Jpet.103.057836  0.656
2003 Roman DL, Walline CC, Rodriguez GJ, Barker EL. Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. European Journal of Pharmacology. 479: 53-63. PMID 14612137 DOI: 10.1016/J.Ejphar.2003.08.056  0.754
2003 Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL. Distinct recognition of substrates by the human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 306: 338-46. PMID 12682215 DOI: 10.1124/Jpet.103.048751  0.749
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