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John J. Turchi - Publications

Affiliations: 
1993-2005 Wright State University, Fairborn, OH, United States 
 2005- Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Biochemistry, Cell Biology
Website:
https://medicine.iu.edu/faculty/5060/turchi-john/
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109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ainembabazi D, Zhang Y, Turchi JJ. The mechanistic role of cardiac glycosides in DNA damage response and repair signaling. Cellular and Molecular Life Sciences : Cmls. 80: 250. PMID 37584722 DOI: 10.1007/s00018-023-04910-9  0.539
2023 Mendoza-Munoz PL, Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Dynlacht JR, Garrett JE, Turchi JJ. Ku-DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks. Nar Cancer. 5: zcad003. PMID 36755959 DOI: 10.1093/narcan/zcad003  0.854
2023 Heyza JR, Ekinci E, Lindquist J, Lei W, Yunker C, Vinothkumar V, Rowbotham R, Polin L, Snider NG, Van Buren E, Watza D, Back JB, Chen W, Mamdani H, Schwartz AG, ... Turchi JJ, et al. ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe. Nar Cancer. 5: zcac045. PMID 36644397 DOI: 10.1093/narcan/zcac045  0.472
2022 Turchi JJ, Pawelczak KS, Weinfeld M, McHugh PJ. Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases. Frontiers in Oncology. 12: 1023500. PMID 36237323 DOI: 10.3389/fonc.2022.1023500  0.844
2022 Ainembabazi D, Geng X, Gavande NS, Turchi JJ, Zhang Y. Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response. Chemmedchem. e202200415. PMID 36054918 DOI: 10.1002/cmdc.202200415  0.421
2022 Kelm JM, Samarbakhsh A, Pillai A, VanderVere-Carozza PS, Aruri H, Pandey DS, Pawelczak KS, Turchi JJ, Gavande NS. Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair. Frontiers in Oncology. 12: 850883. PMID 35463312 DOI: 10.3389/fonc.2022.850883  0.876
2022 VanderVere-Carozza PS, Gavande NS, Jalal SI, Pollok KE, Ekinci E, Heyza J, Patrick SM, Masters A, Turchi JJ, Pawelczak KS. Targeting Replication Protein A for Cancer Therapy. Frontiers in Oncology. 12: 826655. PMID 35251993 DOI: 10.3389/fonc.2022.826655  0.821
2021 Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Turchi JJ, Johnson N, Jonkers J, Rothenberg E, et al. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Molecular Cell. 81: 3227. PMID 34358459 DOI: 10.1016/j.molcel.2021.07.015  0.729
2021 Par S, Vaides S, VanderVere-Carozza PS, Pawelczak KS, Stewart J, Turchi JJ. OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy. Cancers. 13. PMID 34283091 DOI: 10.3390/cancers13133346  0.867
2021 Par S, Vaides S, VanderVere-Carozza PS, Pawelczak KS, Stewart J, Turchi JJ. OB-Folds and Genome Maintenance: Targeting Protein-DNA Interactions for Cancer Therapy. Cancers. 13. PMID 34283091 DOI: 10.3390/cancers13133346  0.6
2021 Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Jonkers J, Johnson N, Turchi JJ, Rothenberg E, et al. Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency. Molecular Cell. PMID 34216544 DOI: 10.1016/j.molcel.2021.06.011  0.786
2020 Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Mendoza-Munoz P, Vernon TL, Hanakahi LA, Summerlin M, Dynlacht JR, Farmer AH, Sears CR, Nasrallah NA, Garrett J, Turchi JJ. Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku-DNA interaction. Nucleic Acids Research. PMID 33119767 DOI: 10.1093/nar/gkaa934  0.883
2020 Sriramkumar S, Matthews TD, Ghobashi AH, Miller SA, VanderVere-Carozza PS, Pawelczak KS, Nephew KP, Turchi JJ, O'Hagan HM. Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer. Molecular Cancer Research : McR. PMID 32801161 DOI: 10.1158/1541-7786.Mcr-20-0396  0.873
2020 Gavande NS, VanderVere-Carozza PS, Pawelczak KS, Vernon TL, Jordan MR, Turchi JJ. Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors. Acs Medicinal Chemistry Letters. 11: 1118-1124. PMID 32550990 DOI: 10.1021/Acsmedchemlett.9B00440  0.872
2019 Turchi JJ, VanderVere-Carozza PS. Small-Molecule Inhibitor Screen for DNA Repair Proteins. Methods in Molecular Biology (Clifton, N.J.). 1999: 217-221. PMID 31127579 DOI: 10.1007/978-1-4939-9500-4_13  0.661
2019 Turchi JJ, VanderVere-Carozza PS, Gavande NS, Pawelczak KS. Abstract 1301: Targeting protein-DNA interactions in the DNA damage response: Lead identification and optimization for novel inhibitors of RPA and Ku Cancer Research. 79: 1301-1301. DOI: 10.1158/1538-7445.Am2019-1301  0.891
2019 Turchi J, Pawelczak KS, Gavande N, VanderVere-Carozza PS. Abstract A095: Targeting protein-DNA interactions in the DNA damage response: Lead identification and optimization for novel inhibitors of RPA and Ku Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-A095  0.889
2018 Keller EJ, Porter M, Garrett JE, Varie M, Wang H, Pollok KE, Turchi JJ, Zaleski JM, Dynlacht JR. Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells. Radiation Research. PMID 29763378 DOI: 10.1667/Rr15019.1  0.526
2018 Turchi JJ, Gavande N, VanderVere-Carozza PS, Vernon T, Pawelczak KS. Abstract LB-A11: Targeting DNA-PK and the DNA damage response via small molecule Ku inhibitors Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Lb-A11  0.897
2017 Pawelczak KS, Gavande NS, VanderVere-Carozza PS, Turchi JJ. Modulating DNA Repair Pathways to Improve Precision Genome Engineering. Acs Chemical Biology. PMID 29210569 DOI: 10.1021/Acschembio.7B00777  0.85
2017 Gavande NS, VanderVere-Carozza P, Mishra AK, Vernon TL, Pawelczak KS, Turchi JJ. Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction. Journal of Medicinal Chemistry. PMID 28933851 DOI: 10.1021/Acs.Jmedchem.7B00780  0.838
2017 Pawelczak KS, Gavande N, VanderVere-Carozza P, Turchi J. Abstract B34: Development of novel small molecule inhibitors targeting DNA repair proteins Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-B34  0.877
2017 Turchi JJ, Gavande N, VanderVere-Carozza P, Vernon T, Pawelczak K. Abstract LB-119: Targeting DNA-PK via small molecule inhibitors of the Ku-DNA interaction Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-119  0.901
2017 Gavande NS, VanderVere-Carozza PS, Vernon TL, Pawelczak K, Turchi JJ. Abstract 1416: Development of small molecule inhibitors for cancer therapy by targeting RPA and XPA nucleotide excision repair proteins Cancer Research. 77: 1416-1416. DOI: 10.1158/1538-7445.Am2017-1416  0.771
2016 Sears CR, Cooney SA, Chin-Sinex H, Mendonca MS, Turchi JJ. DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. Dna Repair. 40: 35-46. PMID 26991853 DOI: 10.1016/J.Dnarep.2016.02.004  0.563
2016 Gavande NS, VanderVere-Carozza PS, Hinshaw HD, Jalal SI, Sears CR, Pawelczak KS, Turchi JJ. DNA repair targeted therapy: The past or future of cancer treatment? Pharmacology & Therapeutics. PMID 26896565 DOI: 10.1016/J.Pharmthera.2016.02.003  0.889
2015 Woods DS, Sears CR, Turchi JJ. Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit. Plos One. 10: e0127321. PMID 25978375 DOI: 10.1371/Journal.Pone.0127321  0.88
2015 Mishra AK, Dormi SS, Turchi AM, Woods DS, Turchi JJ. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochemical Pharmacology. 93: 25-33. PMID 25449597 DOI: 10.1016/J.Bcp.2014.10.013  0.877
2015 VanderVere-Carozza PS, Gavande N, Mishra A, Turchi JJ. Abstract C58: Small molecule inhibitors targeting the interaction of xeroderma pigmentosum group A protein with cisplatin-damaged DNA Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C58  0.739
2015 Gavande N, VanderVere-Carozza PS, Mishra A, Turchi JJ. Abstract C57: Discovery and development of replication protein A (RPA)-DNA interaction inhibitors for cancer chemotherapy Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C57  0.73
2014 Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6504-16. PMID 25316809 DOI: 10.1158/1078-0432.Ccr-14-1553  0.793
2014 Turchi JJ, Woods DS, VanderVere-Carozza P. Testing the metal of ERCC2 in predicting the response to platinum-based therapy. Cancer Discovery. 4: 1118-9. PMID 25274682 DOI: 10.1158/2159-8290.Cd-14-0893  0.794
2014 Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K. Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Molecular and Cellular Biology. 34: 2162-75. PMID 24687855 DOI: 10.1128/Mcb.01554-13  0.704
2014 Peng X, Wang F, Li L, Bum-Erdene K, Xu D, Wang B, Sinn AA, Pollok KE, Sandusky GE, Li L, Turchi JJ, Jalal SI, Meroueh SO. Exploring a structural protein-drug interactome for new therapeutics in lung cancer. Molecular Biosystems. 10: 581-91. PMID 24402119 DOI: 10.1039/C3Mb70503J  0.342
2013 Xu J, Zeng LF, Shen W, Turchi JJ, Zhang ZY. Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma. Biochemical and Biophysical Research Communications. 439: 586-90. PMID 24041688 DOI: 10.1016/J.Bbrc.2013.09.028  0.316
2013 Yakubov B, Chelladurai B, Schmitt J, Emerson R, Turchi JJ, Matei D. Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer. Neoplasia (New York, N.Y.). 15: 609-19. PMID 23730209 DOI: 10.1593/Neo.121878  0.323
2013 Woods D, Turchi JJ. Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer Biology & Therapy. 14: 379-89. PMID 23380594 DOI: 10.4161/Cbt.23761  0.873
2013 Tang J, Fang F, Wang Y, Taverna P, Miller DFB, Choy G, Azab M, Matei D, Pawelczak KS, VanderVere-Carozza P, Wagner M, Turchi JJ, Nephew KP. Abstract 4623: The novel, small molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Cancer Research. 73: 4623-4623. DOI: 10.1158/1538-7445.Am2013-4623  0.807
2013 Nephew KP, Matei D, Taverna P, Fang F, Tang J, Choy G, Lyons J, Azab M, Pilrose J, Turchi J. Abstract IA17: Targeting the methylome for epigenetic resensitization of ovarian cancer Clinical Cancer Research. 19. DOI: 10.1158/1078-0432.Ovca13-Ia17  0.425
2012 Sears CR, Turchi JJ. Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways. The Journal of Biological Chemistry. 287: 24263-72. PMID 22621925 DOI: 10.1074/Jbc.M112.344911  0.602
2012 Bennett SM, Woods DS, Pawelczak KS, Turchi JJ. Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80. International Journal of Biochemistry and Molecular Biology. 3: 36-45. PMID 22509479  0.862
2012 Turchi JJ, Lee J, Hendricks J, Neher TM, Fitch RW. Abstract 4753: Targeting nucleotide excision repair: Chemical synthetic lethality and biology-based combination therapy Cancer Research. 72: 4753-4753. DOI: 10.1158/1538-7445.Am2012-4753  0.399
2012 Turchi JJ, Patrick SM. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications Dna Repair in Cancer Therapy. 109-117. DOI: 10.1016/B978-0-12-384999-1.10006-X  0.625
2011 Jalal S, Earley JN, Turchi JJ. DNA repair: from genome maintenance to biomarker and therapeutic target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6973-84. PMID 21908578 DOI: 10.1158/1078-0432.Ccr-11-0761  0.735
2011 Neher TM, Bodenmiller D, Fitch RW, Jalal SI, Turchi JJ. Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin. Molecular Cancer Therapeutics. 10: 1796-806. PMID 21846830 DOI: 10.1158/1535-7163.Mct-11-0303  0.603
2011 Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, Turchi JJ, Matei D, Meroueh S. Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase. Molecular Cancer Therapeutics. 10: 626-36. PMID 21330459 DOI: 10.1158/1535-7163.Mct-10-0912  0.318
2011 Neher TM, Turchi JJ. Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability. Antioxidants & Redox Signaling. 14: 2461-4. PMID 21235357 DOI: 10.1089/Ars.2010.3748  0.67
2011 Earley JN, Turchi JJ. Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy. Antioxidants & Redox Signaling. 14: 2465-77. PMID 20812782 DOI: 10.1089/Ars.2010.3369  0.724
2011 Pawelczak KS, Bennett SM, Turchi JJ. Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxidants & Redox Signaling. 14: 2531-43. PMID 20698792 DOI: 10.1089/Ars.2010.3368  0.88
2011 Neher TM, Bodenmiller DM, Turchi JJ, Jalal SI. Abstract 2320: In vivo characterization of small molecule inhibitors of replication protein A: Implications for cancer therapy Cancer Research. 71: 2320-2320. DOI: 10.1158/1538-7445.Am2011-2320  0.694
2011 Yakubov B, Chelladurai B, Turchi J, Matei DE. Abstract 1551: Soluble tissue transglutaminase modulates cellular adhesion to matrix and peritoneal metastasis in ovarian cancer Cancer Research. 71: 1551-1551. DOI: 10.1158/1538-7445.Am2011-1551  0.309
2010 Anciano Granadillo VJ, Earley JN, Shuck SC, Georgiadis MM, Fitch RW, Turchi JJ. Targeting the OB-Folds of Replication Protein A with Small Molecules. Journal of Nucleic Acids. 2010: 304035. PMID 21188165 DOI: 10.4061/2010/304035  0.854
2010 Neher TM, Shuck SC, Liu JY, Zhang JT, Turchi JJ. Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. Acs Chemical Biology. 5: 953-65. PMID 20662484 DOI: 10.1021/Cb1000444  0.868
2010 Shuck SC, Turchi JJ. Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function. Cancer Research. 70: 3189-98. PMID 20395205 DOI: 10.1158/0008-5472.Can-09-3422  0.875
2010 Pawelczak KS, Turchi JJ. Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. Dna Repair. 9: 670-7. PMID 20347402 DOI: 10.1016/J.Dnarep.2010.03.002  0.844
2010 Neher TM, Rechkunova NI, Lavrik OI, Turchi JJ. Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct. Biochemistry. 49: 669-78. PMID 20028083 DOI: 10.1021/Bi901575H  0.725
2010 Tahmaseb K, Turchi JJ. Intrinsic hTRF1 fluorescence quenching reveals details of telomere DNA binding activity: impact of DNA length, structure and position of telomeric repeats. Archives of Biochemistry and Biophysics. 493: 207-12. PMID 19887064 DOI: 10.1016/J.Abb.2009.10.015  0.578
2009 Bennett SM, Neher TM, Shatilla A, Turchi JJ. Molecular analysis of Ku redox regulation. Bmc Molecular Biology. 10: 86. PMID 19715578 DOI: 10.1186/1471-2199-10-86  0.655
2009 Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard-Wetherell K, Tahmaseb K, Turchi JJ, Groden J. Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates. The Journal of Biological Chemistry. 284: 14966-77. PMID 19329795 DOI: 10.1074/Jbc.M900195200  0.512
2008 Pawelczak KS, Turchi JJ. A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Research. 36: 4022-31. PMID 18515838 DOI: 10.1093/Nar/Gkn344  0.881
2008 Lehman JA, Hoelz DJ, Turchi JJ. DNA-dependent conformational changes in the Ku heterodimer. Biochemistry. 47: 4359-68. PMID 18355052 DOI: 10.1021/Bi702284C  0.721
2008 Rahal EA, Henricksen LA, Li Y, Turchi JJ, Pawelczak KS, Dixon K. ATM mediates repression of DNA end-degradation in an ATP-dependent manner. Dna Repair. 7: 464-75. PMID 18207464 DOI: 10.1016/J.Dnarep.2007.12.003  0.815
2008 Shuck SC, Short EA, Turchi JJ. Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology. Cell Research. 18: 64-72. PMID 18166981 DOI: 10.1038/Cr.2008.2  0.838
2008 Li GM, Chen DJ, Mitra S, Turchi JJ. A special issue on DNA damage responses and genome maintenance Cell Research. 18: 1-2. DOI: 10.1038/Cr.2008.9  0.582
2006 Andrews BJ, Lehman JA, Turchi JJ. Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. The Journal of Biological Chemistry. 281: 13596-603. PMID 16537541 DOI: 10.1074/Jbc.M512787200  0.688
2006 Turchi JJ. Nitric oxide and cisplatin resistance: NO easy answers. Proceedings of the National Academy of Sciences of the United States of America. 103: 4337-8. PMID 16537366 DOI: 10.1073/Pnas.0601001103  0.448
2006 Trego KS, Turchi JJ. Pre-steady-state binding of damaged DNA by XPC-hHR23B reveals a kinetic mechanism for damage discrimination. Biochemistry. 45: 1961-9. PMID 16460043 DOI: 10.1021/Bi051936T  0.692
2005 Patrick SM, Oakley GG, Dixon K, Turchi JJ. DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair. Biochemistry. 44: 8438-48. PMID 15938633 DOI: 10.1021/bi048057b  0.696
2005 Nuss JE, Patrick SM, Oakley GG, Alter GM, Robison JG, Dixon K, Turchi JJ. DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage. Biochemistry. 44: 8428-37. PMID 15938632 DOI: 10.1021/bi0480584  0.554
2005 Boeckman HJ, Trego KS, Turchi JJ. Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining. Molecular Cancer Research : McR. 3: 277-85. PMID 15886299 DOI: 10.1158/1541-7786.Mcr-04-0032  0.697
2005 Pawelczak KS, Andrews BJ, Turchi JJ. Differential activation of DNA-PK based on DNA strand orientation and sequence bias. Nucleic Acids Research. 33: 152-61. PMID 15640450 DOI: 10.1093/nar/gki157  0.872
2005 Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B. Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. Embo Reports. 6: 83-9. PMID 15592449 DOI: 10.1038/Sj.Embor.7400313  0.624
2004 Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J. Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Human Molecular Genetics. 13: 1919-32. PMID 15229185 DOI: 10.1093/Hmg/Ddh193  0.408
2004 Andrews BJ, Turchi JJ. Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair. Molecular Cancer Therapeutics. 3: 385-91. PMID 15078981  0.602
2003 Chai Q, Zheng L, Zhou M, Turchi JJ, Shen B. Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation. Biochemistry. 42: 15045-52. PMID 14690413 DOI: 10.1021/Bi035364T  0.582
2003 Tornaletti S, Patrick SM, Turchi JJ, Hanawalt PC. Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA. The Journal of Biological Chemistry. 278: 35791-7. PMID 12829693 DOI: 10.1074/Jbc.M305394200  0.337
2003 Oakley GG, Patrick SM, Yao J, Carty MP, Turchi JJ, Dixon K. RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry. 42: 3255-64. PMID 12641457 DOI: 10.1021/Bi026377U  0.547
2002 Ramilo C, Gu L, Guo S, Zhang X, Patrick SM, Turchi JJ, Li GM. Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Molecular and Cellular Biology. 22: 2037-46. PMID 11884592 DOI: 10.1128/Mcb.22.7.2037-2046.2002  0.553
2002 Patrick SM, Turchi JJ. Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activity. The Journal of Biological Chemistry. 277: 16096-101. PMID 11859086 DOI: 10.1074/jbc.M200816200  0.669
2002 Hermanson-Miller IL, Turchi JJ. Strand-specific binding of RPA and XPA to damaged duplex DNA. Biochemistry. 41: 2402-8. PMID 11841234 DOI: 10.1021/Bi0112863  0.712
2001 Turchi JJ. DNA-Dependent Protein Kinase in Apoptosis. Methods in Molecular Medicine. 39: 693-700. PMID 21340832 DOI: 10.1385/1-59259-071-3:693  0.518
2001 Smucker EJ, Turchi JJ. TRF1 inhibits telomere C-strand DNA synthesis in vitro. Biochemistry. 40: 2426-32. PMID 11327863 DOI: 10.1021/Bi001871O  0.716
2001 Patrick SM, Turchi JJ. Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants. The Journal of Biological Chemistry. 276: 22630-7. PMID 11278662 DOI: 10.1074/jbc.M010314200  0.602
2000 Turchi JJ, Henkels KM, Zhou Y. Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK. Nucleic Acids Research. 28: 4634-41. PMID 11095672  0.698
2000 Hermanson IL, Turchi JJ. Overexpression and purification of human XPA using a baculovirus expression system. Protein Expression and Purification. 19: 1-11. PMID 10833384 DOI: 10.1006/prep.2000.1224  0.594
1999 Turchi JJ, Henkels KM, Hermanson IL, Patrick SM. Interactions of mammalian proteins with cisplatin-damaged DNA. Journal of Inorganic Biochemistry. 77: 83-7. PMID 10626358 DOI: 10.1016/S0162-0134(99)00145-2  0.682
1999 Vaisman A, Lim SE, Patrick SM, Copeland WC, Hinkle DC, Turchi JJ, Chaney SG. Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts. Biochemistry. 38: 11026-39. PMID 10460158 DOI: 10.1021/Bi9909187  0.641
1999 Patrick SM, Turchi JJ. Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA. The Journal of Biological Chemistry. 274: 14972-8. PMID 10329699 DOI: 10.1074/jbc.274.21.14972  0.663
1998 Patrick SM, Turchi JJ. Human replication protein A preferentially binds cisplatin-damaged duplex DNA in vitro. Biochemistry. 37: 8808-15. PMID 9628743 DOI: 10.1021/bi9730590  0.663
1997 Patrick SM, Henkels KM, Turchi JJ. High-mobility group 1 protein inhibits helicase catalyzed displacement of cisplatin-damaged DNA. Biochimica Et Biophysica Acta. 1354: 279-90. PMID 9427537 DOI: 10.1016/S0167-4781(97)00136-X  0.65
1997 Henkels KM, Turchi JJ. Induction of apoptosis in cisplatin-sensitive and -resistant human ovarian cancer cell lines. Cancer Research. 57: 4488-92. PMID 9377558  0.573
1997 Mayo LD, Turchi JJ, Berberich SJ. Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Research. 57: 5013-6. PMID 9371494  0.539
1997 Turchi JJ, Patrick SM, Henkels KM. Mechanism of DNA-dependent protein kinase inhibition by cis-diamminedichloroplatinum(II)-damaged DNA. Biochemistry. 36: 7586-93. PMID 9200710 DOI: 10.1021/bi963124q  0.692
1997 Reveal PM, Henkels KM, Turchi JJ. Synthesis of the mammalian telomere lagging strand in vitro. The Journal of Biological Chemistry. 272: 11678-81. PMID 9115215 DOI: 10.1074/jbc.272.18.11678  0.456
1996 Turchi JJ, Henkels K. Human Ku autoantigen binds cisplatin-damaged DNA but fails to stimulate human DNA-activated protein kinase. The Journal of Biological Chemistry. 271: 13861-7. PMID 8662830 DOI: 10.1074/jbc.271.23.13861  0.678
1996 Turchi JJ, Li M, Henkels KM. Cisplatin-DNA binding specificity of calf high-mobility group 1 protein. Biochemistry. 35: 2992-3000. PMID 8608137 DOI: 10.1021/bi951843j  0.652
1996 Turchi JJ, Henkels K. Human ku autoantigen binds cisplatin damaged dna but fails to stimulate dna-activated protein kinase Faseb Journal. 10.  0.672
1994 Murante RS, Huang L, Turchi JJ, Bambara RA. The calf 5'- to 3'-exonuclease is also an endonuclease with both activities dependent on primers annealed upstream of the point of cleavage. The Journal of Biological Chemistry. 269: 1191-6. PMID 8288581  0.512
1994 Turchi JJ, Huang L, Murante RS, Kim Y, Bambara RA. Enzymatic completion of mammalian lagging-strand DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 91: 9803-7. PMID 7524089 DOI: 10.1073/Pnas.91.21.9803  0.642
1994 Huang L, Kim Y, Turchi JJ, Bambara RA. Structure-specific cleavage of the RNA primer from Okazaki fragments by calf thymus RNase HI. The Journal of Biological Chemistry. 269: 25922-7. PMID 7523396  0.398
1993 Turchi JJ, Bambara RA. Completion of mammalian lagging strand DNA replication using purified proteins. The Journal of Biological Chemistry. 268: 15136-41. PMID 8392066  0.64
1993 Huang L, Turchi JJ, Wahl AF, Bambara RA. Effects of the anticancer drug cis-diamminedichloroplatinum(II) on the activities of calf thymus DNA polymerase epsilon. Biochemistry. 32: 841-8. PMID 8380711 DOI: 10.1021/Bi00054A015  0.754
1993 Huang L, Turchi JJ, Wahl AF, Bambara RA. Activity of calf thymus DNA helicase E on cis-diamminedichloroplatinum (II)-damaged DNA. The Journal of Biological Chemistry. 268: 26731-7. PMID 8253808  0.527
1992 Siegal G, Turchi JJ, Jessee CB, Mallaber LM, Bambara RA, Myers TW. Structural relationships between two forms of DNA polymerase epsilon from calf thymus. The Journal of Biological Chemistry. 267: 3991-9. PMID 1740447  0.504
1992 Turchi JJ, Murante RS, Bambara RA. DNA substrate specificity of DNA helicase E from calf thymus. Nucleic Acids Research. 20: 6075-80. PMID 1334262 DOI: 10.1093/Nar/20.22.6075  0.771
1992 Siegal G, Turchi JJ, Myers TW, Bambara RA. A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon. Proceedings of the National Academy of Sciences of the United States of America. 89: 9377-81. PMID 1329095 DOI: 10.1073/Pnas.89.20.9377  0.756
1992 Turchi JJ, Siegal G, Bambara RA. DNA helicase E and DNA polymerase epsilon functionally interact for displacement synthesis. Biochemistry. 31: 9008-15. PMID 1327108 DOI: 10.1021/Bi00152A043  0.76
1992 Siegal G, Turchi JJ, Jessee CB, Myers TW, Bambara RA. A novel DNA helicase from calf thymus. The Journal of Biological Chemistry. 267: 13629-35. PMID 1320024  0.583
1991 Turchi JJ, Weisman GA, Ortwerth BJ. Transfer RNA(4lys) and cell cycle progression: characterization of ts-694 cells. Experimental Cell Research. 195: 536-40. PMID 2070834 DOI: 10.1016/0014-4827(91)90408-M  0.622
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