Robert Bittman - Publications

Affiliations: 
City University of New York, New York, NY, United States 
Area:
Biochemistry

289 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wang X, Maruvada R, Morris AJ, Liu JO, Wolfgang MJ, Baek DJ, Bittman R, Kim KS. Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. Plos Pathogens. 12: e1005926. PMID 27711202 DOI: 10.1371/journal.ppat.1005926  0.6
2016 Vogel A, Scheidt HA, Baek DJ, Bittman R, Huster D. Structure and dynamics of the aliphatic cholesterol side chain in membranes as studied by (2)H NMR spectroscopy and molecular dynamics simulation. Physical Chemistry Chemical Physics : Pccp. 18: 3730-8. PMID 26762541 DOI: 10.1039/c5cp05084g  1
2015 Camp SM, Chiang ET, Sun C, Usatyuk PV, Bittman R, Natarajan V, Garcia JG, Dudek SM. Reprint of "Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720". Chemistry and Physics of Lipids. PMID 26496151 DOI: 10.1016/j.chemphyslip.2015.10.004  1
2015 Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M. Ceramide channel: Structural basis for selective membrane targeting. Chemistry and Physics of Lipids. PMID 26408265 DOI: 10.1016/j.chemphyslip.2015.09.007  1
2015 Camp SM, Chiang ET, Sun C, Usatyuk PV, Bittman R, Natarajan V, Garcia JG, Dudek SM. Pulmonary Endothelial Cell Barrier Enhancement by Novel FTY720 Analogs: Methoxy-FTY720, Fluoro-FTY720, and β-Glucuronide-FTY720. Chemistry and Physics of Lipids. 191: 16-24. PMID 26272033 DOI: 10.1016/j.chemphyslip.2015.08.004  0.72
2015 Mahendran A, Ghogare AA, Bittman R, Arthur G, Greer A. Synthesis and antiproliferative properties of a new ceramide analog of varacin. Chemistry and Physics of Lipids. PMID 26254858 DOI: 10.1016/j.chemphyslip.2015.07.023  1
2015 Kim YA, Day J, Lirette CA, Costain WJ, Johnston LJ, Bittman R. Synthesis and photochemical properties of PEGylated coumarin-caged ceramides for cell studies. Chemistry and Physics of Lipids. PMID 26200920 DOI: 10.1016/j.chemphyslip.2015.07.006  1
2015 Hawkes D, Jones KL, Smyth RP, Pereira CF, Bittman R, Jaworowski A, Mak J. Properties of HIV-1 associated cholesterol in addition to raft formation are important for virus infection. Virus Research. 210: 18-21. PMID 26191619 DOI: 10.1016/j.virusres.2015.06.023  1
2015 Boomkamp SD, Byun HS, Ubhi S, Jiang HR, Pyne S, Bittman R, Pyne NJ. Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis. Chemistry and Physics of Lipids. PMID 26187854 DOI: 10.1016/j.chemphyslip.2015.07.001  1
2015 Schweitzer KS, Chen SX, Law S, Van Demark MJ, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, Kranz WD, Carroll CJ, Ray BD, Bittman R, Goodpaster J, et al. Endothelial disruptive pro-inflammatory effects of nicotine and e-cigarette vapor exposures. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00411.2015. PMID 25979079 DOI: 10.1152/ajplung.00411.2014  1
2015 Woodcock JM, Coolen C, Goodwin KL, Baek DJ, Bittman R, Samuel MS, Pitson SM, Lopez AF. Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics. Oncotarget. PMID 25971334  1
2015 Wang L, Bittman R, Garcia JG, Dudek SM. Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. Microvascular Research. 99: 102-9. PMID 25862132 DOI: 10.1016/j.mvr.2015.03.007  1
2015 Vilchèze C, Leung LW, Bittman R, Jacobs WR. Synthesis and biological activity of alkynoic acids derivatives against mycobacteria Chemistry and Physics of Lipids. DOI: 10.1016/j.chemphyslip.2015.08.001  1
2015 Bittman R, Gomez-Muñoz A. Utilization of caged ceramide and ceramide 1-phosphate analogs for monitoring cellular events after photoactivation Bioactive Sphingolipids in Cancer Biology and Therapy. 385-398. DOI: 10.1007/978-3-319-20750-6_17  1
2014 Ouro A, Arana L, Rivera IG, Ordoñez M, Gomez-Larrauri A, Presa N, Simón J, Trueba M, Gangoiti P, Bittman R, Gomez-Muñoz A. Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration. Biochemical Pharmacology. 92: 642-50. PMID 25450673 DOI: 10.1016/j.bcp.2014.10.005  0.36
2014 Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. The Journal of Clinical Investigation. 124: 5368-84. PMID 25347472 DOI: 10.1172/JCI74188  0.56
2014 Venkataswamy MM, Ng TW, Kharkwal SS, Carreño LJ, Johnson AJ, Kunnath-Velayudhan S, Liu Z, Bittman R, Jervis PJ, Cox LR, Besra GS, Wen X, Yuan W, Tsuji M, Li X, et al. Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells. Plos One. 9: e108383. PMID 25255287 DOI: 10.1371/journal.pone.0108383  1
2014 Evangelisti C, Evangelisti C, Teti G, Chiarini F, Falconi M, Melchionda F, Pession A, Bertaina A, Locatelli F, McCubrey JA, Beak DJ, Bittman R, Pyne S, Pyne NJ, Martelli AM. Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics. Oncotarget. 5: 7886-901. PMID 25226616  1
2014 Meyer T, Baek DJ, Bittman R, Haralampiev I, Müller P, Herrmann A, Huster D, Scheidt HA. Membrane properties of cholesterol analogs with an unbranched aliphatic side chain. Chemistry and Physics of Lipids. 184: 1-6. PMID 25173446 DOI: 10.1016/j.chemphyslip.2014.08.002  1
2014 Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. Plos One. 9: e103743. PMID 25157633 DOI: 10.1371/journal.pone.0103743  1
2014 Liu Z, Thacker SG, Fernandez-Castillejo S, Neufeld EB, Remaley AT, Bittman R. Synthesis of cholesterol analogues bearing BODIPY fluorophores by Suzuki or Liebeskind-Srogl cross-coupling and evaluation of their potential for visualization of cholesterol pools. Chembiochem : a European Journal of Chemical Biology. 15: 2087-96. PMID 25154602 DOI: 10.1002/cbic.201402042  1
2014 Fruhwürth S, Kovacs WJ, Bittman R, Messner S, Röhrl C, Stangl H. Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver. Histochemistry and Cell Biology. 142: 645-55. PMID 25059650 DOI: 10.1007/s00418-014-1251-9  1
2014 Fruhwürth S, Krieger S, Winter K, Rosner M, Mikula M, Weichhart T, Bittman R, Hengstschläger M, Stangl H. Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production. Biochimica Et Biophysica Acta. 1841: 944-53. PMID 24713582 DOI: 10.1016/j.bbalip.2014.03.014  1
2014 Samadder P, Byun HS, Bittman R, Arthur G. A fluorescent alkyllysophospholipid analog exhibits selective cytotoxicity against the hormone-insensitive prostate cancer cell line PC3. Anti-Cancer Agents in Medicinal Chemistry. 14: 528-38. PMID 24628239 DOI: 10.2174/1871520614666140309223603  1
2014 Arthur G, Bittman R. Glycosylated antitumor ether lipids: activity and mechanism of action. Anti-Cancer Agents in Medicinal Chemistry. 14: 592-606. PMID 24628233 DOI: 10.2174/1871520614666140309231144  1
2014 Ohotski J, Rosen H, Bittman R, Pyne S, Pyne NJ. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. Cellular Signalling. 26: 1040-7. PMID 24486401 DOI: 10.1016/j.cellsig.2014.01.023  1
2014 Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, et al. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 40: 105-16. PMID 24412610 DOI: 10.1016/j.immuni.2013.12.004  1
2014 Wang L, Sammani S, Moreno-Vinasco L, Letsiou E, Wang T, Camp SM, Bittman R, Garcia JG, Dudek SM. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Critical Care Medicine. 42: e189-99. PMID 24335440 DOI: 10.1097/CCM.0000000000000097  1
2014 Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The Febs Journal. 281: 1017-28. PMID 24314137 DOI: 10.1111/febs.12674  1
2014 Pyne NJ, Ohotski J, Bittman R, Pyne S. The role of sphingosine 1-phosphate in inflammation and cancer. Advances in Biological Regulation. 54: 121-9. PMID 24070975 DOI: 10.1016/j.jbior.2013.08.005  1
2013 Tonelli F, Alossaimi M, Natarajan V, Gorshkova I, Berdyshev E, Bittman R, Watson DG, Pyne S, Pyne NJ. The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells. Biomolecules. 3: 316-33. PMID 24970170 DOI: 10.3390/biom3020316  0.56
2013 Byun HS, Pyne S, Macritchie N, Pyne NJ, Bittman R. Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells. Medchemcomm. 4. PMID 24396570 DOI: 10.1039/C3MD00201B  1
2013 Scheidt HA, Meyer T, Nikolaus J, Baek DJ, Haralampiev I, Thomas L, Bittman R, Müller P, Herrmann A, Huster D. Cholesterol's aliphatic side chain modulates membrane properties. Angewandte Chemie (International Ed. in English). 52: 12848-51. PMID 24382636 DOI: 10.1002/anie.201306753  1
2013 Baek DJ, MacRitchie N, Anthony NG, Mackay SP, Pyne S, Pyne NJ, Bittman R. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 56: 9310-27. PMID 24164513 DOI: 10.1021/jm401399c  1
2013 García-Martínez V, Villanueva J, Torregrosa-Hetland CJ, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutiérrez LM. Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells. Plos One. 8: e75845. PMID 24073281 DOI: 10.1371/journal.pone.0075845  1
2013 Baek DJ, Bittman R. Synthesis of cholesterol analogs having varying length alkyl side chains including cholesterol-23, 23, 24, 24, 25, 26, 26, 26, 27, 27, 27-d(11) as probes of cholesterol's functions and properties. Chemistry and Physics of Lipids. 175: 99-104. PMID 24012903 DOI: 10.1016/j.chemphyslip.2013.08.003  1
2013 Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, ... ... Bittman R, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of Clinical Investigation. 123: 4144-57. PMID 23999433 DOI: 10.1172/JCI68951  1
2013 Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 122: 1923-34. PMID 23926298 DOI: 10.1182/blood-2013-03-492181  1
2013 Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, ... Bittman R, et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology. 84: 415-24. PMID 23793291 DOI: 10.1124/mol.113.087080  1
2013 Carter Ramirez DM, Kim YA, Bittman R, Johnston LJ. Lipid Phase Separation and Protein-Ganglioside Clustering in Supported Bilayers Are Induced by Photorelease of Ceramide. Soft Matter. 9: 4890-4899. PMID 23667384 DOI: 10.1039/C3SM50240F  1
2013 Milles S, Meyer T, Scheidt HA, Schwarzer R, Thomas L, Marek M, Szente L, Bittman R, Herrmann A, Günther Pomorski T, Huster D, Müller P. Organization of fluorescent cholesterol analogs in lipid bilayers - lessons from cyclodextrin extraction. Biochimica Et Biophysica Acta. 1828: 1822-8. PMID 23583923 DOI: 10.1016/j.bbamem.2013.04.002  1
2013 Liu Z, MacRitchie N, Pyne S, Pyne NJ, Bittman R. Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorganic & Medicinal Chemistry. 21: 2503-10. PMID 23541833 DOI: 10.1016/j.bmc.2013.02.042  1
2013 Martel C, Li W, Fulp B, Platt AM, Gautier EL, Westerterp M, Bittman R, Tall AR, Chen SH, Thomas MJ, Kreisel D, Swartz MA, Sorci-Thomas MG, Randolph GJ. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. The Journal of Clinical Investigation. 123: 1571-9. PMID 23524964 DOI: 10.1172/JCI63685  1
2013 Natarajan V, Dudek SM, Jacobson JR, Moreno-Vinasco L, Huang LS, Abassi T, Mathew B, Zhao Y, Wang L, Bittman R, Weichselbaum R, Berdyshev E, Garcia JG. Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. American Journal of Respiratory Cell and Molecular Biology. 49: 6-17. PMID 23449739 DOI: 10.1165/rcmb.2012-0411TR  1
2013 Ramirez DM, Pitre SP, Kim YA, Bittman R, Johnston LJ. Photouncaging of ceramides promotes reorganization of liquid-ordered domains in supported lipid bilayers. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 3380-7. PMID 23402522 DOI: 10.1021/la3039158  1
2013 Baek DJ, MacRitchie N, Pyne NJ, Pyne S, Bittman R. Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications (Cambridge, England). 49: 2136-8. PMID 23388656 DOI: 10.1039/c3cc00181d  1
2013 Ouro A, Arana L, Gangoiti P, Rivera IG, Ordoñez M, Trueba M, Lankalapalli RS, Bittman R, Gomez-Muñoz A. Ceramide 1-phosphate stimulates glucose uptake in macrophages. Cellular Signalling. 25: 786-95. PMID 23333242 DOI: 10.1016/j.cellsig.2013.01.009  1
2013 Watson DG, Tonelli F, Alossaimi M, Williamson L, Chan E, Gorshkova I, Berdyshev E, Bittman R, Pyne NJ, Pyne S. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells Cellular Signalling. 25: 1011-1017. PMID 23314175 DOI: 10.1016/j.cellsig.2013.01.002  1
2013 Tonelli F, Alossaimi M, Williamson L, Tate RJ, Watson DG, Chan E, Bittman R, Pyne NJ, Pyne S. The sphingosine kinaseinhibitor 2-(phyroxyanilino)-4-(pchlorophenyl) thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism British Journal of Pharmacology. 168: 1497-1505. PMID 23113536 DOI: 10.1111/bph.12035  1
2012 Byun HS, Bittman R. Practical multigram-scale synthesis of 4,6- and 4,8-sphingadienes, chemopreventive sphingoid bases. Chemistry and Physics of Lipids. 165: 794-801. PMID 23085149 DOI: 10.1016/j.chemphyslip.2012.10.002  1
2012 Liu Z, Courtney AN, Metelitsa LS, Bittman R. C-Glycosphingolipids with an exo-methylene substituent: stereocontrolled synthesis and immunostimulation of mouse and human natural killer T lymphocytes. Chembiochem : a European Journal of Chemical Biology. 13: 1733-7. PMID 22782839 DOI: 10.1002/cbic.201200374  1
2012 Walters JW, Anderson JL, Bittman R, Pack M, Farber SA. Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid. Chemistry & Biology. 19: 913-25. PMID 22749558 DOI: 10.1016/j.chembiol.2012.05.018  1
2012 Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochemical and Biophysical Research Communications. 424: 18-21. PMID 22727907 DOI: 10.1016/j.bbrc.2012.06.012  1
2012 Lim KG, Tonelli F, Berdyshev E, Gorshkova I, Leclercq T, Pitson SM, Bittman R, Pyne S, Pyne NJ. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. The International Journal of Biochemistry & Cell Biology. 44: 1457-64. PMID 22634604 DOI: 10.1016/j.biocel.2012.05.012  1
2012 Blom T, Li Z, Bittman R, Somerharju P, Ikonen E. Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case. Traffic (Copenhagen, Denmark). 13: 1234-43. PMID 22607065 DOI: 10.1111/j.1600-0854.2012.01379.x  0.6
2012 Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer. Carcinogenesis. 33: 1726-35. PMID 22581840 DOI: 10.1093/carcin/bgs174  0.96
2012 Perera MN, Lin SH, Peterson YK, Bielawska A, Szulc ZM, Bittman R, Colombini M. Bax and Bcl-xL exert their regulation on different sites of the ceramide channel. The Biochemical Journal. 445: 81-91. PMID 22494048 DOI: 10.1042/BJ20112103  1
2012 Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawski J, Bielawska A, Bittman R, Colombini M. Ceramide channels: influence of molecular structure on channel formation in membranes. Biochimica Et Biophysica Acta. 1818: 1291-301. PMID 22365970 DOI: 10.1016/j.bbamem.2012.02.010  1
2012 Liu Z, Bittman R. Synthesis of C-glycoside analogues of α-galactosylceramide via linear allylic C-H oxidation and allyl cyanate to isocyanate rearrangement. Organic Letters. 14: 620-3. PMID 22233351 DOI: 10.1021/ol2032448  1
2012 Arana L, Gangoiti P, Ouro A, Rivera IG, Ordoñez M, Trueba M, Lankalapalli RS, Bittman R, Gomez-Muñoz A. Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate. Experimental Cell Research. 318: 350-60. PMID 22155727 DOI: 10.1016/j.yexcr.2011.11.013  1
2012 Chang PP, Barral P, Fitch J, Pratama A, Ma CS, Kallies A, Hogan JJ, Cerundolo V, Tangye SG, Bittman R, Nutt SL, Brink R, Godfrey DI, Batista FD, Vinuesa CG. Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nature Immunology. 13: 35-43. PMID 22120117 DOI: 10.1038/ni.2166  1
2012 Röhrl C, Meisslitzer-Ruppitsch C, Bittman R, Li Z, Pabst G, Prassl R, Strobl W, Neumüller J, Ellinger A, Pavelka M, Stangl H. Combined light and electron microscopy using diaminobenzidine photooxidation to monitor trafficking of lipids derived from lipoprotein particles. Current Pharmaceutical Biotechnology. 13: 331-40. PMID 21470121 DOI: 10.2174/138920112799095338  1
2011 Samadder P, Byun HS, Bittman R, Arthur G. An active endocytosis pathway is required for the cytotoxic effects of glycosylated antitumor ether lipids. Anticancer Research. 31: 3809-18. PMID 22110203  1
2011 Patel O, Cameron G, Pellicci DG, Liu Z, Byun HS, Beddoe T, McCluskey J, Franck RW, Castaño AR, Harrak Y, Llebaria A, Bittman R, Porcelli SA, Godfrey DI, Rossjohn J. NKT TCR recognition of CD1d-α-C-galactosylceramide. Journal of Immunology (Baltimore, Md. : 1950). 187: 4705-13. PMID 21964029 DOI: 10.4049/jimmunol.1100794  1
2011 Liu Z, Byun HS, Bittman R. Total synthesis of α-1C-galactosylceramide, an immunostimulatory C-glycosphingolipid, and confirmation of the stereochemistry in the first-generation synthesis. The Journal of Organic Chemistry. 76: 8588-98. PMID 21958232 DOI: 10.1021/jo201450s  1
2011 Sankaranarayanan S, Kellner-Weibel G, de la Llera-Moya M, Phillips MC, Asztalos BF, Bittman R, Rothblat GH. A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol. Journal of Lipid Research. 52: 2332-40. PMID 21957199 DOI: 10.1194/jlr.D018051  1
2011 Pyne S, Bittman R, Pyne NJ. Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules. Cancer Research. 71: 6576-82. PMID 21940750 DOI: 10.1158/0008-5472.CAN-11-2364  1
2011 Kim YA, Ramirez DM, Costain WJ, Johnston LJ, Bittman R. A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide. Chemical Communications (Cambridge, England). 47: 9236-8. PMID 21761060 DOI: 10.1039/c1cc12345a  1
2011 Valentine WJ, Godwin VI, Osborne DA, Liu J, Fujiwara Y, Van Brocklyn J, Bittman R, Parrill AL, Tigyi G. FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2. The Journal of Biological Chemistry. 286: 30513-25. PMID 21719706 DOI: 10.1074/jbc.M111.263442  1
2011 Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, et al. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3388-400. PMID 21712494 DOI: 10.1096/fj.11-183970  1
2011 Lim KG, Sun C, Bittman R, Pyne NJ, Pyne S. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cellular Signalling. 23: 1590-5. PMID 21620961 DOI: 10.1016/j.cellsig.2011.05.010  1
2011 Lim KG, Tonelli F, Li Z, Lu X, Bittman R, Pyne S, Pyne NJ. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. The Journal of Biological Chemistry. 286: 18633-40. PMID 21464128 DOI: 10.1074/jbc.M111.220756  1
2011 Kumar A, Byun HS, Bittman R, Saba JD. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cellular Signalling. 23: 1144-52. PMID 21385609 DOI: 10.1016/j.cellsig.2011.02.009  0.96
2011 Wüstner D, Solanko L, Sokol E, Garvik O, Li Z, Bittman R, Korte T, Herrmann A. Quantitative assessment of sterol traffic in living cells by dual labeling with dehydroergosterol and BODIPY-cholesterol. Chemistry and Physics of Lipids. 164: 221-35. PMID 21291873 DOI: 10.1016/j.chemphyslip.2011.01.004  1
2011 Berdyshev EV, Goya J, Gorshkova I, Prestwich GD, Byun HS, Bittman R, Natarajan V. Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. Analytical Biochemistry. 408: 12-8. PMID 20804717 DOI: 10.1016/j.ab.2010.08.026  0.96
2010 Byun HS, Bittman R. Selective deuterium labeling of the sphingoid backbone: facile syntheses of 3,4,5-trideuterio-d-erythro-sphingosine and 3-deuterio-d-erythro-sphingomyelin. Chemistry and Physics of Lipids. 163: 809-13. PMID 20836998 DOI: 10.1016/j.chemphyslip.2010.09.001  1
2010 Bucki R, Ku?akowska A, Byfield FJ, Zendzian-Piotrowska M, Baranowski M, Marzec M, Winer JP, Ciccarelli NJ, Górski J, Drozdowski W, Bittman R, Janmey PA. Plasma gelsolin modulates cellular response to sphingosine 1-phosphate American Journal of Physiology - Cell Physiology. 299: C1516-C1523. PMID 20810916 DOI: 10.1152/ajpcell.00051.2010  1
2010 Mahendran A, Vuong A, Aebisher D, Gong Y, Bittman R, Arthur G, Kawamura A, Greer A. Synthesis, characterization, mechanism of decomposition, and antiproliferative activity of a class of PEGylated benzopolysulfanes structurally similar to the natural product varacin. The Journal of Organic Chemistry. 75: 5549-57. PMID 20704430 DOI: 10.1021/jo100870q  1
2010 Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cellular Signalling. 22: 1536-42. PMID 20570726 DOI: 10.1016/j.cellsig.2010.05.022  1
2010 Valentine WJ, Kiss GN, Liu J, E S, Gotoh M, Murakami-Murofushi K, Pham TC, Baker DL, Parrill AL, Lu X, Sun C, Bittman R, Pyne NJ, Tigyi G. (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Cellular Signalling. 22: 1543-53. PMID 20566326 DOI: 10.1016/j.cellsig.2010.05.023  1
2010 Habrukowich C, Han DK, Le A, Rezaul K, Pan W, Ghosh M, Li Z, Dodge-Kafka K, Jiang X, Bittman R, Hla T. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. The Journal of Biological Chemistry. 285: 26825-31. PMID 20558741 DOI: 10.1074/jbc.M110.147058  1
2010 Byun HS, Bittman R, Samadder P, Arthur G. Synthesis and antitumor activity of ether glycerophospholipids bearing a carbamate moiety at the sn-2 position: selective sensitivity against prostate cancer cell lines. Chemmedchem. 5: 1045-52. PMID 20533503 DOI: 10.1002/cmdc.201000060  1
2010 Liu Z, Byun HS, Bittman R. Asymmetric synthesis of D-ribo-phytosphingosine from 1-tetradecyne and (4-methoxyphenoxy)acetaldehyde. The Journal of Organic Chemistry. 75: 4356-64. PMID 20527744 DOI: 10.1021/jo100707d  1
2010 Liu Z, Byun HS, Bittman R. Synthesis of immunostimulatory alpha-C-galactosylceramide glycolipids via Sonogashira coupling, asymmetric epoxidation, and trichloroacetimidate-mediated epoxide opening. Organic Letters. 12: 2974-7. PMID 20518525 DOI: 10.1021/ol1009976  1
2010 Lankalapalli RS, Baksa A, Liliom K, Bittman R. Synthesis and properties of a photoactivatable analogue of psychosine (beta-Galactosylsphingosine). Chemmedchem. 5: 682-6. PMID 20209561 DOI: 10.1002/cmdc.201000018  1
2010 Bode C, Sensken SC, Peest U, Beutel G, Thol F, Levkau B, Li Z, Bittman R, Huang T, Tölle M, van der Giet M, Gräler MH. Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. Journal of Cellular Biochemistry. 109: 1232-43. PMID 20186882 DOI: 10.1002/jcb.22507  0.6
2010 Heller B, Adu-Gyamfi E, Smith-Kinnaman W, Babbey C, Vora M, Xue Y, Bittman R, Stahelin RV, Wells CD. Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain. The Journal of Biological Chemistry. 285: 12308-20. PMID 20080965 DOI: 10.1074/jbc.M109.096230  1
2010 Blom T, Bäck N, Mutka AL, Bittman R, Li Z, de Lera A, Kovanen PT, Diczfalusy U, Ikonen E. FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. Circulation Research. 106: 720-9. PMID 20056921 DOI: 10.1161/CIRCRESAHA.109.204396  0.6
2010 Liu Z, Gong Y, Byun HS, Bittman R. An improved two-step synthetic route to primary allylic alcohols from aldehydes New Journal of Chemistry. 34: 470-475. DOI: 10.1039/b9nj00710e  1
2009 Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Research. 69: 9457-64. PMID 19934323 DOI: 10.1158/0008-5472.CAN-09-2341  0.96
2009 Lankalapalli RS, Ouro A, Arana L, Gómez-Muñoz A, Bittman R. Caged ceramide 1-phosphate analogues: synthesis and properties. The Journal of Organic Chemistry. 74: 8844-7. PMID 19908915 DOI: 10.1021/jo902076w  1
2009 Camp SM, Bittman R, Chiang ET, Moreno-Vinasco L, Mirzapoiazova T, Sammani S, Lu X, Sun C, Harbeck M, Roe M, Natarajan V, Garcia JG, Dudek SM. Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro. The Journal of Pharmacology and Experimental Therapeutics. 331: 54-64. PMID 19592667 DOI: 10.1124/jpet.109.153544  1
2009 Jahreiss L, Renna M, Bittman R, Arthur G, Rubinsztein DC. 1-O-Hexadecyl-2-O-methyl-3-O-(2'-acetamido-2'-deoxy-beta-D-glucopyranosyl)-sn-glycerol (Gln) induces cell death with more autophagosomes which is autophagy-independent. Autophagy. 5: 835-46. PMID 19550143  0.56
2009 Lankalapalli RS, Eckelkamp JT, Sircar D, Ford DA, Subbaiah PV, Bittman R. Synthesis and antioxidant properties of an unnatural plasmalogen analogue bearing a trans O-vinyl ether linkage. Organic Letters. 11: 2784-7. PMID 19499908 DOI: 10.1021/ol9009078  1
2009 Samadder P, Bittman R, Byun HS, Arthur G. A glycosylated antitumor ether lipid kills cells via paraptosis-like cell death. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 87: 401-14. PMID 19370058 DOI: 10.1139/o08-147  1
2009 Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. The Journal of Biological Chemistry. 284: 16090-8. PMID 19357080 DOI: 10.1074/jbc.M807438200  1
2009 Ariola FS, Li Z, Cornejo C, Bittman R, Heikal AA. Membrane fluidity and lipid order in ternary giant unilamellar vesicles using a new bodipy-cholesterol derivative. Biophysical Journal. 96: 2696-708. PMID 19348752 DOI: 10.1016/j.bpj.2008.12.3922  0.6
2009 Lu X, Sun C, Valentine WJ, Shuyu E, Liu J, Tigyi G, Bittman R. Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720. The Journal of Organic Chemistry. 74: 3192-5. PMID 19296586 DOI: 10.1021/jo900023u  1
2009 Bandhuvula P, Li Z, Bittman R, Saba JD. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochemical and Biophysical Research Communications. 380: 366-70. PMID 19250638 DOI: 10.1016/j.bbrc.2009.01.106  1
2009 Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. The Journal of Biological Chemistry. 284: 5467-77. PMID 19119142 DOI: 10.1074/jbc.M805186200  1
2009 Subbaiah PV, Sircar D, Lankalapalli RS, Bittman R. Effect of double bond geometry in sphingosine base on the antioxidant function of sphingomyelin. Archives of Biochemistry and Biophysics. 481: 72-9. PMID 18952047 DOI: 10.1016/j.abb.2008.10.005  1
2008 Bartels T, Lankalapalli RS, Bittman R, Beyer K, Brown MF. Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy. Journal of the American Chemical Society. 130: 14521-32. PMID 18839945 DOI: 10.1021/ja801789t  1
2008 Marks DL, Bittman R, Pagano RE. Use of Bodipy-labeled sphingolipid and cholesterol analogs to examine membrane microdomains in cells. Histochemistry and Cell Biology. 130: 819-32. PMID 18820942 DOI: 10.1007/s00418-008-0509-5  1
2008 Hölttä-Vuori M, Uronen RL, Repakova J, Salonen E, Vattulainen I, Panula P, Li Z, Bittman R, Ikonen E. BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organisms. Traffic (Copenhagen, Denmark). 9: 1839-49. PMID 18647169 DOI: 10.1111/j.1600-0854.2008.00801.x  0.6
2008 Chiantia S, Ries J, Chwastek G, Carrer D, Li Z, Bittman R, Schwille P. Role of ceramide in membrane protein organization investigated by combined AFM and FCS. Biochimica Et Biophysica Acta. 1778: 1356-64. PMID 18346453 DOI: 10.1016/j.bbamem.2008.02.008  0.6
2008 Soni SP, LoCascio DS, Liu Y, Williams JA, Bittman R, Stillwell W, Wassall SR. Docosahexaenoic acid enhances segregation of lipids between : 2H-NMR study. Biophysical Journal. 95: 203-14. PMID 18339742 DOI: 10.1529/biophysj.107.123612  1
2008 Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. Journal of Lipid Research. 49: 597-606. PMID 18156591 DOI: 10.1194/jlr.M700414-JLR200  1
2007 Li Z, Bittman R. Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes Journal of Organic Chemistry. 72: 8376-8382. PMID 17914846 DOI: 10.1021/jo701475q  1
2007 Coelho RP, Payne SG, Bittman R, Spiegel S, Sato-Bigbee C. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. The Journal of Pharmacology and Experimental Therapeutics. 323: 626-35. PMID 17726159 DOI: 10.1124/jpet.107.123927  1
2007 Megha, Sawatzki P, Kolter T, Bittman R, London E. Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts). Biochimica Et Biophysica Acta. 1768: 2205-12. PMID 17574203 DOI: 10.1016/j.bbamem.2007.05.007  1
2007 Watterson KR, Berg KM, Kapitonov D, Payne SG, Miner AS, Bittman R, Milstien S, Ratz PH, Spiegel S. Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2818-28. PMID 17449719 DOI: 10.1096/fj.06-7326com  1
2007 Zhao Y, Kalari SK, Usatyuk PV, Gorshkova I, He D, Watkins T, Brindley DN, Sun C, Bittman R, Garcia JG, Berdyshev EV, Natarajan V. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. The Journal of Biological Chemistry. 282: 14165-77. PMID 17379599 DOI: 10.1074/jbc.M701279200  1
2007 Singh RD, Holicky EL, Cheng ZJ, Kim SY, Wheatley CL, Marks DL, Bittman R, Pagano RE. Inhibition of caveolar uptake, SV40 infection, and beta1-integrin signaling by a nonnatural glycosphingolipid stereoisomer. The Journal of Cell Biology. 176: 895-901. PMID 17371832 DOI: 10.1083/jcb.200609149  1
2007 Bittman R, Li Z, Samadder P, Arthur G. Anticancer activity of a ceramide analog containing a disulfide linkage. Cancer Letters. 251: 53-8. PMID 17141948 DOI: 10.1016/j.canlet.2006.10.026  1
2006 Lu X, Song L, Metelitsa LS, Bittman R. Synthesis and evaluation of an alpha-C-galactosylceramide analogue that induces Th1-biased responses in human natural killer T cells. Chembiochem : a European Journal of Chemical Biology. 7: 1750-6. PMID 17009272 DOI: 10.1002/cbic.200600197  1
2006 Singh RD, Liu Y, Wheatley CL, Holicky EL, Makino A, Marks DL, Kobayashi T, Subramaniam G, Bittman R, Pagano RE. Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry. The Journal of Biological Chemistry. 281: 30660-8. PMID 16893900 DOI: 10.1074/jbc.M606194200  1
2006 Shaw JE, Epand RF, Sinnathamby K, Li Z, Bittman R, Epand RM, Yip CM. Tracking peptide-membrane interactions: insights from in situ coupled confocal-atomic force microscopy imaging of NAP-22 peptide insertion and assembly. Journal of Structural Biology. 155: 458-69. PMID 16889981 DOI: 10.1016/j.jsb.2006.04.015  0.6
2006 Baker DL, Fujiwara Y, Pigg KR, Tsukahara R, Kobayashi S, Murofushi H, Uchiyama A, Murakami-Murofushi K, Koh E, Bandle RW, Byun HS, Bittman R, Fan D, Murph M, Mills GB, et al. Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. The Journal of Biological Chemistry. 281: 22786-93. PMID 16782709 DOI: 10.1074/jbc.M512486200  0.96
2006 Nylund M, Kjellberg MA, Molotkovsky JG, Byun HS, Bittman R, Mattjus P. Molecular features of phospholipids that affect glycolipid transfer protein-mediated galactosylceramide transfer between vesicles. Biochimica Et Biophysica Acta. 1758: 807-12. PMID 16777057 DOI: 10.1016/j.bbamem.2006.04.023  0.96
2006 Liu Y, Bittman R. Synthesis of fluorescent lactosylceramide stereoisomers. Chemistry and Physics of Lipids. 142: 58-69. PMID 16631151 DOI: 10.1016/j.chemphyslip.2006.03.001  1
2006 Sun C, Bittman R. A photoreactive analogue of the immunosuppressant FTY720 Journal of Organic Chemistry. 71: 2200-2202. PMID 16497020 DOI: 10.1021/jo0526237  1
2006 Li Z, Mintzer E, Bittman R. First synthesis of free cholesterol-BODIPY conjugates Journal of Organic Chemistry. 71: 1718-1721. PMID 16468832 DOI: 10.1021/jo052029x  1
2006 Mintzer E, Sargsyan H, Bittman R. Lysophosphatidic acid and lipopolysaccharide bind to the PIP2-binding domain of gelsolin Biochimica Et Biophysica Acta - Biomembranes. 1758: 85-89. PMID 16460666 DOI: 10.1016/j.bbamem.2005.12.009  1
2006 Li Z, Baker DL, Tigyi G, Bittman R. Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins Journal of Organic Chemistry. 71: 629-635. PMID 16408973 DOI: 10.1021/jo052030w  1
2006 Mehnert T, Jacob K, Bittman R, Beyer K. Structure and lipid interaction of N-palmitoylsphingomyelin in bilayer membranes as revealed by2H-NMR spectroscopy Biophysical Journal. 90: 939-946. PMID 16284259 DOI: 10.1529/biophysj.105.063271  1
2006 Byun HS, Lu X, Bittman R. Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors Synthesis. 2447-2474. DOI: 10.1055/s-2006-942475  1
2006 Lu X, Bittman R. Enantioselective synthesis of the phosphate esters of the immunosuppressive lipid FTY720 Tetrahedron Letters. 47: 825-827. DOI: 10.1016/j.tetlet.2005.11.092  1
2005 Lu X, Bittman R. Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. The Journal of Organic Chemistry. 70: 4746-50. PMID 15932314 DOI: 10.1021/jo050513u  1
2005 Lu X, Arthur G, Bittman R. Synthesis of a novel ceramide analogue via Tebbe methylenation and evaluation of its antiproliferative activity. Organic Letters. 7: 1645-8. PMID 15816773 DOI: 10.1021/ol0503440  1
2005 Arthur G, Samadder P, Bittman R. ET-18-OCH3 inhibits the phosphorylation and activation of p70 S6 kinase in MCF-7 cells. Anticancer Research. 25: 95-100. PMID 15816524  1
2005 Lu X, Bittman R. An efficient synthesis of D-ribo- and L-lyxo-phytosphingosine from D-tartaric acid Tetrahedron Letters. 46: 3165-3168. DOI: 10.1016/j.tetlet.2005.03.063  1
2005 Lu X, Bittman R. Efficient and versatile synthesis of (2S,3R)-sphingosine and its 2-azido-3-O-benzylsphingosine analogue Tetrahedron Letters. 46: 1873-1875. DOI: 10.1016/j.tetlet.2005.01.104  1
2004 Sun C, Bittman R. An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with α-lithiated alkylphosphonic esters Journal of Organic Chemistry. 69: 7694-7699. PMID 15497998 DOI: 10.1021/jo0487404  1
2004 Brockman HL, Momsen MM, Brown RE, He L, Chun J, Byun HS, Bittman R. The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior. Biophysical Journal. 87: 1722-31. PMID 15345551 DOI: 10.1529/biophysj.104.044529  0.96
2004 Lu X, Byun HS, Bittman R. Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon. The Journal of Organic Chemistry. 69: 5433-8. PMID 15287793 DOI: 10.1021/jo0493065  1
2004 Li Z, Mintzer E, Bittman R. The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine Chemistry and Physics of Lipids. 130: 197-201. PMID 15172836 DOI: 10.1016/j.chemphyslip.2004.03.001  1
2004 Samadder P, Bittman R, Byun HS, Arthur G. Synthesis and use of novel ether phospholipid enantiomers to probe the molecular basis of the antitumor Effects of alkyllysophospholipids: correlation of differential activation of c-Jun NH(2)-terminal protein kinase with antiproliferative effects in neuronal tumor cells. Journal of Medicinal Chemistry. 47: 2710-3. PMID 15115414 DOI: 10.1021/jm0302748  1
2004 Bittman R. The 2003 ASBMB-Avanti Award in Lipids Address: Applications of novel synthetic lipids to biological problems Chemistry and Physics of Lipids. 129: 111-131. PMID 15081855 DOI: 10.1016/j.chemphyslip.2004.01.004  1
2004 Johnson CR, Chun J, Bittman R, Jarvis WD. Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. The Journal of Pharmacology and Experimental Therapeutics. 309: 452-61. PMID 14724218 DOI: 10.1124/jpet.103.060665  1
2003 Crawford KW, Bittman R, Chun J, Byun HS, Bowen WD. Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared to normal breast epithelial cells. Cellular and Molecular Biology (Noisy-Le-Grand, France). 49: 1017-23. PMID 14682383  0.96
2003 Smit JM, Waarts BL, Bittman R, Wilschut J. Liposomes as Target Membranes in the Study of Virus Receptor Interaction and Membrane Fusion Methods in Enzymology. 372: 374-392. PMID 14610825 DOI: 10.1016/S0076-6879(03)72022-9  1
2003 Lu X, Cseh S, Byun HS, Tigyi G, Bittman R. Total synthesis of two photoactivatable analogues of the growth-factor-like mediator sphingosine 1-phosphate: differential interaction with protein targets. The Journal of Organic Chemistry. 68: 7046-50. PMID 12946147 DOI: 10.1021/jo034828q  1
2003 Samadder P, Richards C, Bittman R, Bhullar RP, Arthur G. The antitumor ether lipid 1-Q-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1. Anticancer Research. 23: 2291-5. PMID 12894505  1
2003 Chun J, Byun HS, Arthur G, Bittman R. Synthesis and growth inhibitory activity of chiral 5-hydroxy-2-N-acyl-(3E)-sphingenines: ceramides with an unusual sphingoid backbone. The Journal of Organic Chemistry. 68: 355-9. PMID 12530860 DOI: 10.1021/jo026242u  1
2003 Chun J, Byun HS, Bittman R. First asymmetric synthesis of 6-hydroxy-4-sphingenine-containing ceramides. Use of chiral propargylic alcohols to prepare a lipid found in human skin. The Journal of Organic Chemistry. 68: 348-54. PMID 12530859 DOI: 10.1021/jo026240+  1
2002 Harris JR, Bhakdi S, Meissner U, Scheffler D, Bittman R, Li G, Zitzer A, Palmer M. Interaction of the Vibrio cholerae cytolysin (VCC) with cholesterol, some cholesterol esters, and cholesterol derivatives: a TEM study. Journal of Structural Biology. 139: 122-35. PMID 12406694  1
2002 Waarts BL, Bittman R, Wilschut J. Sphingolipid and cholesterol dependence of alphavirus membrane fusion: Lack of correlation with lipid raft formation in target liposomes Journal of Biological Chemistry. 277: 38141-38147. PMID 12138173 DOI: 10.1074/jbc.M206998200  1
2002 Smit JM, Li G, Schoen P, Corver J, Bittman R, Lin KC, Wilschut J. Fusion of alphaviruses with liposomes is a non-leaky process. Febs Letters. 521: 62-6. PMID 12067727  1
2002 Chun J, Li G, Byun HS, Bittman R. Synthesis of new trans double-bond sphingolipid analogues: Delta(4,6) and Delta(6) ceramides. The Journal of Organic Chemistry. 67: 2600-5. PMID 11950306 DOI: 10.1021/jo0162639  1
2002 Mintzer EA, Waarts BL, Wilschut J, Bittman R. Behavior of a photoactivatable analog of cholesterol, 6-photocholesterol, in model membranes. Febs Letters. 510: 181-4. PMID 11801250 DOI: 10.1016/S0014-5793(01)03271-9  1
2002 Chun J, Byun HS, Bittman R. Preparation of chiral propargylic alcohols from α,β-unsaturated esters Tetrahedron Letters. 43: 8043-8045. DOI: 10.1016/S0040-4039(02)01968-8  1
2002 Chun J, Li G, Byun HS, Bittman R. A concise route to D-erythro-sphingosine from N-Boc-L-serine derivatives via sulfoxide or sulfone intermediates Tetrahedron Letters. 43: 375-377.  1
2001 Smit JM, Bittman R, Wilschut J. Deacylation of the transmembrane domains of Sindbis virus envelope glycoproteins E1 and E2 does not affect low-pH-induced viral membrane fusion activity Febs Letters. 498: 57-61. PMID 11389898 DOI: 10.1016/S0014-5793(01)02495-4  1
2001 Zhong N, Byun HS, Bittman R. Hydrophilic cholesterol-binding molecular imprinted polymers Tetrahedron Letters. 42: 1839-1841. DOI: 10.1016/S0040-4039(01)00045-4  1
2001 Li G, Samadder P, Arthur G, Bittman R. Synthesis and antiproliferative properties of a photoactivatable analogue of ET-18-OCH3 Tetrahedron. 57: 8925-8932. DOI: 10.1016/S0040-4020(01)00901-2  1
2001 Bittman R, Perkins WR, Swenson CE. TLC ELL-12. Oncolytic Drugs of the Future. 26: 1052-1058.  1
2000 Bittman R, Verbicky CA. Methanolysis of sphingomyelin: Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine Journal of Lipid Research. 41: 2089-2093. PMID 11108743  1
2000 Chun J, He L, Byun HS, Bittman R. Synthesis of ceramide analogues having the C(4)-C(5) bond of the long-chain base as part of an aromatic or heteroaromatic system. The Journal of Organic Chemistry. 65: 7634-40. PMID 11076626 DOI: 10.1021/jo001227f  1
2000 He L, Byun HS, Bittman R. Stereoselective preparation of ceramide and its skeleton backbone modified analogues via cyclic thionocarbonate intermediates derived by catalytic asymmetric dihydroxylation of alpha,beta-unsaturated ester precursors. The Journal of Organic Chemistry. 65: 7627-33. PMID 11076625 DOI: 10.1021/jo001226n  1
2000 He L, Byun HS, Bittman R. A stereocontrolled, efficient synthetic route to bioactive sphingolipids: synthesis of phytosphingosine and phytoceramides from unsaturated ester precursors via cyclic sulfate intermediates. The Journal of Organic Chemistry. 65: 7618-26. PMID 11076624 DOI: 10.1021/jo001225v  1
2000 Qin D, Sullivan R, Berkowitz WF, Bittman R, Rotenberg SA. Inhibition of protein kinase Cα by dequalinium analogues: Dependence on linker length and geometry Journal of Medicinal Chemistry. 43: 1413-1417. PMID 10753478 DOI: 10.1021/jm990340z  1
2000 Li G, Bittman R. Synthesis of novel phenoxy-linked diazirine glycero- and sphingolipid probes via trialkylaryltin intermediates Tetrahedron Letters. 41: 6737-6741.  1
2000 Byun HS, Zhong N, Bittman R. 6A-O-p-toluenesulfonyl-β-cyclodextrin: (β-Cyclodextrin, 6A-(4-methylbenzenesulfonate)) Organic Syntheses. 77: 225-230.  1
2000 Byun HS, He L, Bittman R. Cyclic sulfites and cyclic sulfates in organic synthesis Tetrahedron. 56: 7051-7091.  1
1999 Smit JM, Bittman R, Wilschut J. Low-pH-dependent fusion of Sindbis virus with receptor-free cholesterol- and sphingolipid-containing liposomes Journal of Virology. 73: 8476-8484. PMID 10482600  1
1999 He L, Wanunu M, Byun HS, Bittman R. Regioselective and stereospecific azidation of 1,2- and 1,3-diols by azidotrimethylsilane via a Mitsunobu reaction Journal of Organic Chemistry. 64: 6049-6055. DOI: 10.1021/jo9906375  1
1999 Qin D, Byun HS, Bittman R. Synthesis of plasmalogen via 2,3-bis-O-(4'-methoxybenzyl)-sn-glycerol Journal of the American Chemical Society. 121: 662-668. DOI: 10.1021/ja982837o  1
1998 Samadder P, Byun HS, Bittman R, Arthur G. Glycosylated antitumor ether lipids are more effective against oncogene-transformed fibroblasts than alkyllysophospholipids Anticancer Research. 18: 465-470. PMID 9568121  1
1998 Arthur G, Bittman R. The inhibition of cell signaling pathways by antitumor ether lipids Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1390: 85-102. PMID 9487143 DOI: 10.1016/S0005-2760(97)00163-X  1
1998 He L, Byun HS, Bittman R. A new synthetic route to chiral glycerolipid precursors using a cyclic sulfate synthon: Preparation of 1-o-hexadecyl-3-O-(4′-methoxyphenyl)-SN- glycerol and its 1-thio and 1-AZA analogues Journal of Organic Chemistry. 63: 5696-5699. DOI: 10.1021/jo980471s  1
1998 Leung LW, Vilchèze C, Bittman R. Synthesis of fluorescent phosphatidylinositols using a novel inositol H- phosphonate Tetrahedron Letters. 39: 2921-2924. DOI: 10.1016/S0040-4039(98)00418-3  1
1998 Zhong N, Byun HS, Bittman R. An improved synthesis of 6-O-monotosyl-6-deoxy-β-cyclodextrin Tetrahedron Letters. 39: 2919-2920. DOI: 10.1016/S0040-4039(98)00417-1  1
1998 He L, Byun HS, Bittman R. Efficient synthesis of chiral α,β-epoxyesters via a cyclic sulfate intermediate Tetrahedron Letters. 39: 2071-2074. DOI: 10.1016/S0040-4039(98)00190-7  1
1998 Byun HS, Sadlofsky JA, Bittman R. Enantioselective Synthesis of 3-Deoxy-(R)-sphingomyelin from (S)-1-(4′-Methoxyphenyl)glycerol Journal of Organic Chemistry. 63: 2560-2563.  1
1997 Leung LW, Bittman R. A convenient synthesis of D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and L-myo-inositol 1,4,5-trisphosphate (Ins(3,5,6)P3) Carbohydrate Research. 305: 171-179. PMID 9581273 DOI: 10.1016/S0008-6215(97)00267-X  1
1997 Bittman R. Has nature designed the cholesterol side chain for optimal interaction with phospholipids? Sub-Cellular Biochemistry. 28: 145-171. PMID 9090294  1
1996 Bittman R, Swords B, Liliom K, Tigyi G. Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids Journal of Lipid Research. 37: 391-398. PMID 9026536  1
1996 Ali S, Bittman R. Differential scanning calorimetry study of the influence of phospholipid analogs with a carbonyl-terminated sn-2 chain on the interdigitated phases formed by 1-stearoyl-2-capryl-sn-glycero-3-phosphatidylcholine (C18:C10-PC) Journal of Lipid Research. 37: 2305-2309. PMID 8978482  1
1996 Liliom K, Bittman R, Swords B, Tigyi G. N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors Molecular Pharmacology. 50: 616-623. PMID 8794902  1
1996 Berger A, Bittman R, Schmidt RR, Spiegel S. Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity. Molecular Pharmacology. 50: 451-7. PMID 8794881  1
1996 Zhou X, Lu X, Richard C, Xiong W, Litchfield DW, Bittman R, Arthur G. 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells. The Journal of Clinical Investigation. 98: 937-44. PMID 8770865 DOI: 10.1172/JCI118877  1
1996 Marino-Albernas JR, Bittman R, Peters A, Mayhew E. Synthesis and growth inhibitory properties of glycosides of 1-O- hexadecyl-2-O-methyl-sn-glycerol, analogs of the antitumor ether lipid ET- 18-OCH3 (edelfosine) Journal of Medicinal Chemistry. 39: 3241-3247. PMID 8765506 DOI: 10.1021/jm960164j  1
1996 Karasavvas N, Erukulla RK, Bittman R, Lockshin R, Zakeri Z. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine: The ceramide amide group is not required for apoptosis European Journal of Biochemistry. 236: 729-737. PMID 8612651  1
1996 Gericke A, Brauner JW, Erukulla RK, Bittman R, Mendelsohn R. In-situ investigation of partially deuterated fatty acid and phospholipid monolayers at the air-water interface by IR reflection-absorption spectroscopy Thin Solid Films. 284: 428-431. DOI: 10.1016/S0040-6090(95)08358-8  1
1996 Byun HS, Bittman R. Efficient stereospecific synthesis of diamide analogs of phosphatidylcholine starting from 1-(4′-methoxyphenyl)-sn-glycerol Journal of Organic Chemistry. 61: 8706-8708.  1
1996 Qin D, Byun HS, Bittman R. Synthesis of half-deuterated palmitic and palmitoleic acids from THF-d8 Journal of Organic Chemistry. 61: 8709-8711.  1
1996 Gericke A, Moore DJ, Erukulla RK, Bittman R, Mendelsohn R. Partially deuterated phospholipids as IR structure probes of conformational order in bulk and monolayer phases Journal of Molecular Structure. 379: 227-239.  1
1995 Lister MD, Ruan Zs, Bittman R. Interaction of sphingomyelinase with sphingomyelin analogs modified at the C-1 and C-3 positions of the sphingosine backbone Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1256: 25-30. PMID 7742352 DOI: 10.1016/0005-2760(94)00249-X  1
1995 McMullen TPW, Vilcheze C, McElhaney RN, Bittman R. Differential scanning calorimetric study of the effect of sterol side chain length and structure on dipalmitoylphosphatidylcholine thermotropic phase behavior Biophysical Journal. 69: 169-176. PMID 7669894  1
1995 Erukulla RK, Byun HS, Bittman R. Three-step synthesis of platelet-activating factor from chiral glycidol via regioselective monophosphitylation of 1-O-hexadecyl-sn-glycerol Journal of Organic Chemistry. 60: 7706-7708. DOI: 10.1021/jo00128a055  1
1995 Byun HS, Bittman R. A short synthesis of antitumor ether thioglycolipids: Thioglycosidation of a glucose donor with a tributylstannyl sulfide acceptor Tetrahedron Letters. 36: 5143-5146. DOI: 10.1016/0040-4039(95)01015-A  1
1995 Vilchèze C, Bittman R. Diacetylenic sterols: New potentially photopolymerizable lipids Journal of the Chemical Society, Perkin Transactions 1. 91: 2937-2940.  1
1995 Erukulla RK, Byun HS, Locke DC, Bittman R. Stereospecific and regiospecific ring opening of glycidol with primary and secondary alcohols mediated by diisobutylaluminium hydride Journal of the Chemical Society, Perkin Transactions 1. 2199-2200.  1
1994 Lu X, Rengan K, Bittman R, Arthur G. The alpha-anomers and Beta-anomers of 1-o-hexadecyl-2-o-methyl-3-s-thioglucosyl-sn-glycerol inhibit the proliferation of epithelial cancer cell-lines. Oncology Reports. 1: 933-6. PMID 21607469  1
1994 Bittman R, Byun HS, Mercier B, Salari H. Isosteric phosphonate analogs of et-16-ome. synthesis and biological evaluation of the enantiomers of 2′-(trimethylammonio)ethyl 4-(hexadecyloxy)-3-methoxybutanephosphonate and 2′-(trimethylammonio)ethyl 4-(hexadecylthio)-3-methoxybutanephosphonate Journal of Medicinal Chemistry®. 37: 425-430. PMID 8308870  1
1994 Slotte JP, Jungner M, Vilchèze C, Bittman R. Effect of sterol side-chain structure on sterol-phosphatidylcholine interactions in monolayers and small unilamellar vesicles Bba - Biomembranes. 1190: 435-443. PMID 8142447 DOI: 10.1016/0005-2736(94)90105-8  1
1994 Vilcheze C, Bittman R. An efficient asymmetric synthesis of diacylglycerols Journal of Lipid Research. 35: 734-738. PMID 8006527  1
1994 Bittman R. Interaction of cholesterol with sphingomyelin in monolayers and vesicles Biochemistry. 33: 11776-11781. PMID 7918394  1
1994 Erukulla RK, Bittman R. A facile stereoselective synthesis of ether-linked ß -d-maltosyl- and (ß -d-lactosyl-glycerolipids via peracetylated disaccharide α -phosphoramidates Synthetic Communications. 24: 2765-2770. DOI: 10.1080/00397919408010593  1
1994 Kumar Erukulla R, Byun HS, Bittman R. Antitumor phospholipids: A one-pot introduction of a phosphocholine moiety into lipid hydroxy acceptors Tetrahedron Letters. 35: 5783-5784. DOI: 10.1016/S0040-4039(00)78183-4  1
1994 Chandraprakash Reddy K, Byun HS, Bittman R. Antitumor ether lipids: An improved synthesis of ilmofosine and an enantioselective synthesis of an ilmofosine analog Tetrahedron Letters. 35: 2679-2682. DOI: 10.1016/S0040-4039(00)77004-3  1
1994 Byun HS, Reddy KC, Bittman R. Improved syntheses of ethyl α-(bromomethyl)acrylate and 2-methylene-1,3-propanediol via ethyl α-(hydroxymethyl)acrylate Tetrahedron Letters. 35: 1371-1374. DOI: 10.1016/S0040-4039(00)76221-6  1
1994 Kumar ER, Byun HS, Wang S, Bittman R. Preparation of ether-linked 2-acetamido-2-deoxy β-glycolipids via zinc chloride promoted coupling of Ac4GlcNAcCl with lipid hydroxy groups Tetrahedron Letters. 35: 505-508. DOI: 10.1016/S0040-4039(00)75823-0  1
1994 Lohmeyer M, Bittman R. Antitumor ether lipids and alkylphosphocholines Drugs of the Future. 19: 1021-1037.  1
1994 Byun HS, Bittman R. Stereospecific synthesis of thioether glycerophospholipids. Catalytic asymmetric epoxidation followed by in situ borohydride-mediated opening of glycidol with hexadecylmercaptan Journal of Organic Chemistry. 59: 668-671.  1
1994 Byun HS, Kumar ER, Bittman R. Enantioselective syntheses of 1-O-benzyl-sn-glycerol and 1-O-hexadecyl-2-O-methyl-sn-glycerol via asymmetric dihydroxylation of allyl 4-methoxyphenyl ether. Use of AD-mix supplemented with potassium persulfate Journal of Organic Chemistry. 59: 2630-2633.  1
1994 Byun HS, Erukulla RK, Bittman R. Synthesis of sphingomyelin and ceramide 1-phosphate from ceramide without protection of the allylic hydroxyl group Journal of Organic Chemistry. 59: 6495-6498.  1
1994 Lu Xiaoli, Rengan K, Bittman R, Arthur G. The alpha and beta anomers of 1-O-hexadecyl-2-O-methyl-3-S-thioglucosyl-sn-glycerol inhibit the proliferation of epithelial cancer cell lines Oncology Reports. 1: 933-936.  1
1993 Bittman R, Byun HS, Mercier B, Salari H. 2'-(Trimethylammonio)ethyl 4-(hexadecyloxy)-3(S)-methoxybutane- phosphonate: A novel potent antineoplastic agent Journal of Medicinal Chemistry. 36: 297-299. PMID 8423601 DOI: 10.1021/jm00054a017  1
1993 Bittman R. Mycoplasma membrane lipids. Chemical composition and transbilayer distribution Sub-Cellular Biochemistry. 20: 29-52. PMID 8378993  1
1993 Joseph CK, Byun HS, Bittman R, Kolesnick RN. Substrate recognition by ceramide-activated protein kinase: Evidence that kinase activity is proline-directed Journal of Biological Chemistry. 268: 20002-20006. PMID 8376361  1
1993 Slotte JP, Östman AL, Kumar ER, Bittman R. Cholesterol interacts with lactosyl and maltosyl cerebrosides but not with glucosyl or galactosyl cerebrosides in mixed monolayers Biochemistry. 32: 7886-7892. PMID 8347594  1
1993 Byun HS, Bittman R. A one-pot synthesis of dimethyl 2, 3-o-bmjwwenzylidene-l-tartrate from l-tartaric acid Synthetic Communications. 23: 3201-3204. DOI: 10.1080/00397919308011180  1
1993 Berkowitz WF, Pan D, Bittman R. A new approach to archaebacterial lipid models Tetrahedron Letters. 34: 4297-4300. DOI: 10.1016/S0040-4039(00)79333-6  1
1993 Chia NC, Vilchèze C, Bittman R, Mendelsohn R. Interactions of cholesterol and synthetic sterols with phosphatidylcholines As deduced from infrared CH2 wagging progression intensities Journal of the American Chemical Society. 115: 12050-12055.  1
1992 Kan CC, Yan J, Bittman R. Rates of spontaneous exchange of synthetic radiolabeled sterols between lipid vesicles Biochemistry. 31: 1866-1874. PMID 1737039  1
1992 Rottenberg H, Bittman R, Li HL. Resistance to ethanol disordering of membranes from ethanol-fed rats is conferred by all phospholipid classes. Biochimica Et Biophysica Acta. 1123: 282-90. PMID 1536867 DOI: 10.1016/0005-2760(92)90008-J  1
1992 Salari H, Howard S, Bittman R. Synthesis and antineoplastic properties of an ether glycerophosphonocholine, an analog of ET-18-OCH3-GPC Biochemical and Biophysical Research Communications. 187: 603-608. PMID 1530618 DOI: 10.1016/0006-291X(92)91237-K  1
1992 Rhodes DG, Xu Z, Bittman R. Structure of polymerizable lipid bilayers. V: synthesis, bilayer structure and properties of diacetylenic ether and ester lipids Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1128: 93-104. PMID 1390881 DOI: 10.1016/0005-2760(92)90262-T  1
1992 Salari H, Dryden P, Howard S, Bittman R. Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 70: 129-135. PMID 1324692  1
1992 Hui SW, Yu H, Xu Z, Bittman R. Microdomain structures in polymerizable and nonpolymerizable diacetylenic phosphatidylcholine monolayers Langmuir. 8: 2724-2729.  1
1991 Kan CC, Bittman R, Hajdu J. Phospholipids containing nitrogen- and sulfur-linked chains: kinetics of cholesterol exchange between vesicles Bba - Biomembranes. 1066: 95-101. PMID 2065074 DOI: 10.1016/0005-2736(91)90256-8  1
1991 Gronberg L, Ruan ZS, Bittman R, Slotte JP. Interaction of cholesterol with synthetic sphingomyelin derivatives in mixed monolayers Biochemistry. 30: 10746-10754. PMID 1931994  1
1991 Kan CC, Bittman R. Spontaneous rates of sitosterol and cholesterol exchange between phospholipid vesicles and between lysophospholipid dispersions: Evidence that desorption rate is impeded by the 24α-ethyl group of sitosterol Journal of the American Chemical Society. 113: 6650-6656.  1
1991 Xu Z, Byun HS, Bittman R. Synthesis of photopolymerizable long-chain conjugated diacetylenic acids and alcohols from butadiyne synthons Journal of Organic Chemistry. 56: 7183-7186.  1
1990 Bittman R, Clejan S, Hui SW. Increased rates of lipid exchange between Mycoplasma capricolum membranes and vesicles in relation to the propensity of forming nonbilayer lipid structures. The Journal of Biological Chemistry. 265: 15110-7. PMID 2394716  1
1990 Ali S, Bittman R. Synthesis of optically active 1-acyl-2-O-alkyl-sn-glycero-3-phosphocholine via 1-O-benzyl-sn-glycerol 3-arenesulfonate Biochemistry and Cell Biology. 68: 360-365. PMID 2350497  1
1990 Yan J, Bittman R. A facile synthesis of [14C]epicholesterol Journal of Lipid Research. 31: 160-162. PMID 2313200  1
1990 Halladay HN, Stark RE, Ali S, Bittman R. Magic-angle spinning NMR studies of molecular organization in multibilayers formed by 1-octadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine Biophysical Journal. 58: 1449-1461. PMID 2275962  1
1990 Kan CC, Bittman R. Constraint of the spontaneous intermembrane movement of sitosterol by its 24α-ethyl group Journal of the American Chemical Society. 112: 884-886.  1
1989 Bittman R, Witzke NM. Conversion of methylallyl alcohol into C2-methyl-1,2-di-O-hexadecylglycerophosphocholine, a conformationally restricted phospholipid Chemistry and Physics of Lipids. 50: 99-103. PMID 2766429 DOI: 10.1016/0009-3084(89)90032-7  1
1989 Pugh EL, Bittman R, Fugler L, Kates M. Comparison of steady-state fluorescence polarization and urea permeability of phosphatidylcholine and phosphatidylsulfocholine liposomes as a function of sterol structure Chemistry and Physics of Lipids. 50: 43-50. PMID 2758524 DOI: 10.1016/0009-3084(89)90024-8  1
1989 Ali S, Bittman R. Mixed-chain phosphatidylcholine analogues modified in the choline moiety: preparation of isomerically pure phospholipids with bulky head groups and one acyl chain twice as long as the other Chemistry and Physics of Lipids. 50: 11-21. PMID 2758523 DOI: 10.1016/0009-3084(89)90022-4  1
1989 Ali S, Lin HN, Bittman R, Huang CH. Binary mixtures of saturated and unsaturated mixed-chain phosphatidylcholines. A differential scanning calorimetry study Biochemistry. 28: 522-528. PMID 2713328  1
1989 Byun HS, Bittman R. A two-step synthesis of (R)- and (S)-benzylglycidyl ether Tetrahedron Letters. 30: 2751-2754. DOI: 10.1016/S0040-4039(00)99116-0  1
1989 Guivisdalsky PN, Bittman R. Regiospecific opening of glycidyl derivatives mediated by boron trifluoride. Asymmetric synthesis of ether-linked phospholipids Journal of Organic Chemistry. 54: 4637-4642.  1
1989 Guivisdalsky PN, Bittman R. Glycidyl derivatives as chiral C3 synthons. Ring opening catalyzed by BF3 etherate Journal of the American Chemical Society. 111: 3077-3079.  1
1989 Guivisdalsky PN, Bittman R. An efficient stereocontrolled route to both enantiomers of platelet activating factor and analogues with long-chain esters at C2: Saturated and unsaturated ether glycerolipids by opening of glycidyl arenesulfonates Journal of Organic Chemistry. 54: 4643-4648.  1
1988 Guivisdalsky PN, Bittman R. Novel enantioselective synthesis of platelet activating factor and its enantiomer via ring opening of glycidyl tosylate with 1-hexadecanol Tetrahedron Letters. 29: 4393-4396. DOI: 10.1016/S0040-4039(00)80503-1  1
1988 Ali S, Bittman R. Facile diacylation of glycidyl tosylate. Chiral synthesis of symmetric-chain glycerophospholipids Journal of Organic Chemistry. 53: 5547-5549.  1
1987 Mattai J, Witzke NM, Bittman R, Shipley GG. Structure and thermotropic properties of hydrated 1-eicosyl-2-dodecyl-rac-glycero-3-phosphocholine and 1-dodecyl-2-eicosyl-rac-glycero-3-phosphocholine bilayer membranes Biochemistry. 26: 623-633. PMID 3828326  1
1987 Bittman R, Clejan S. Kinetics of cholesterol and phospholipid exchange between mycoplasma membranes and lipid vesicles Israel Journal of Medical Sciences. 23: 398-402. PMID 3667216  1
1987 Bittman R, Clejan S, Fugler L. Interaction of cholesterol with glycerophosphono- and glycerophosphinocholines Annals of the New York Academy of Sciences. 494: 189-191.  1
1986 Bittman R, Clejan S, Fugler L, Rosenthal AF. The effect of cholesterol on glycerophosphono- and glycerophosphinocholines. Permeability measurements in lipid vesicles Bba - Biomembranes. 855: 265-270. PMID 3947623 DOI: 10.1016/0005-2736(86)90173-2  1
1986 Bittman R, Blau L. Permeability behavior of liposomes prepared from fatty acids and fatty acid methyl esters Bba - Biomembranes. 863: 115-120. PMID 3778908 DOI: 10.1016/0005-2736(86)90393-7  1
1986 Lewis EN, Bittman R, Levin IW. Methyl group substitution at C(1), C(2) or C(3) of the glycerol backbone of a diether phosphocholine: a comparative study of bilayer chain disorder in the gel and liquid-crystalline phases. Biochimica Et Biophysica Acta. 861: 44-52. PMID 3756154 DOI: 10.1016/0005-2736(86)90401-3  1
1986 Witzke NM, Bittman R. Convenient synthesis of racemic mixed-chain ether glycerophosphocholines from fatty alkyl allyl ethers: Useful analogs for biophysical studies Journal of Lipid Research. 27: 344-351. PMID 3734631  1
1986 Bittman R, Clejan S, Fugler L. Rates of lipid movement between mycoplasma cells and vesicles and between small unilamellar vesicles are decreased by sphingomyelin incorporation Annals of the New York Academy of Sciences. 372-374.  1
1985 Witzke NM, Bittman R. Synthesis of phosphatidylcholine analogs with an alkyl group at C1 or C3 of the glycerol moiety Journal of Lipid Research. 26: 623-628. PMID 4020301  1
1985 Bittman R, Clejan S, Robinson BP, Witzke NM. Kinetics of cholesterol and phospholipid exchange from membranes containing cross-linked proteins or cross-linked phosphatidylethanolamines Biochemistry. 24: 1403-1409. PMID 3986182  1
1985 Fugler L, Clejan S, Bittman R. Movement of cholesterol between vesicles prepared with different phospholipids or sizes Journal of Biological Chemistry. 260: 4098-4102. PMID 3980469  1
1985 Clejan S, Bittman R. Rates of amphotericin B and filipin association with sterols. A study of changes in sterol structure and phospholipid composition of vesicles Journal of Biological Chemistry. 260: 2884-2889. PMID 3972808  1
1985 Yang SY, Bittman R, Schulz H. Channeling of a β-oxidation intermediate on the large subunit of the fatty acid oxidation complex from Escherichia coli Journal of Biological Chemistry. 260: 2862-2868. PMID 3882701  1
1984 Bittman R, Clejan S, Lund-Katz S, Phillips MC. Influence of cholesterol on bilayers of ester- and ether-linked phospholipids Permeability and 13C-nuclear magnetic resonance measurements Bba - Biomembranes. 772: 117-126. PMID 6722139 DOI: 10.1016/0005-2736(84)90034-8  1
1984 Witzke NM, Bittman R. Dissociation kinetics and equilibrium binding properties of polyene antibiotic complexes with phosphatidylcholine/sterol vesicles Biochemistry. 23: 1668-1674. PMID 6722119  1
1984 Clejan S, Bittman R. Distribution and movement of sterols with different side chain structures between the two leaflets of the membrane bilayer of mycoplasma cells Journal of Biological Chemistry. 259: 449-455. PMID 6706946  1
1984 Clejan S, Bittman R. Kinetics of cholesterol and phospholipid exchange between Mycoplasma gallisepticum cells and lipid vesicles. Alterations in membrane cholesterol and protein content Journal of Biological Chemistry. 259: 441-448. PMID 6706945  1
1984 Clejan S, Bittman R. Decreases in rates of lipid exchange between Mycoplasma gallisepticum cells and unilamellar vesicles by incorporation of sphingomyelin Journal of Biological Chemistry. 259: 10823-10826. PMID 6469983  1
1984 Vambutas V, Beattie DS, Bittman R. Isolation of protein(s) containing chloride ion transport activity from thylakoid membranes Archives of Biochemistry and Biophysics. 232: 538-548. PMID 6465888 DOI: 10.1016/0003-9861(84)90571-X  1
1984 Blau L, Stern RB, Bittman R. The stoichiometry of A23187- and X537A-mediated calcium ion transport across lipid bilayers Bba - Biomembranes. 778: 219-223. PMID 6437447 DOI: 10.1016/0005-2736(84)90465-6  1
1984 Bittman R, Rosenthal AF, Vargas LA. Synthesis of phospholipids via dimethylphosphoryl chloride Chemistry and Physics of Lipids. 34: 201-205. DOI: 10.1016/0009-3084(84)90044-6  1
1983 Bittman R, Clejan S, Rottem S. Transbilayer distribution of sterols in mycoplasma membranes Yale Journal of Biology and Medicine. 56: 397-403. PMID 6382819  1
1982 Shirvan MH, Rottem S, Neeman Z, Bittman R. Isolation of mycoplasma membranes by dicyclohexylcarbodiimide-induced lysis Journal of Bacteriology. 149: 1124-1128. PMID 7061381  1
1982 Readio JD, Bittman R. Equilibrium binding of amphotericin B and its methyl ester and borate complex to sterols Bba - Biomembranes. 685: 219-224. PMID 7059605 DOI: 10.1016/0005-2736(82)90103-1  1
1982 Gross Z, Rottem S, Bittman R. Phospholipid interconversions in Mycoplasma capricolum European Journal of Biochemistry. 122: 169-174. PMID 6277632  1
1981 Rottem S, Shinar D, Bittman R. Symmetrical distribution and rapid transbilayer movement of cholesterol in Mycoplasma gallisepticum membranes Bba - Biomembranes. 649: 572-580. PMID 7317418 DOI: 10.1016/0005-2736(81)90161-9  1
1981 Bittman R, Blau L, Clejan S, Rottem S. Determination of cholesterol asymmetry by rapid kinetics of filipin-cholesterol association: effect of modification in lipids and proteins. Biochemistry. 20: 2425-32. PMID 7236612  1
1981 Clejan S, Bittman R, Rottem S. Effects of sterol structure and exogenous lipids on the transbilayer distribution of sterols in the membrane of Mycoplasma capricolum Biochemistry. 20: 2200-2204. PMID 7236590  1
1978 Bittman R. Sterol-polyene antibiotic complexation: Probe of membrane structure Lipids. 13: 686-691. PMID 723481 DOI: 10.1007/BF02533746  1
1978 Blau L, Bittman R. Cholesterol distribution between the two halves of the lipid bilayer of human erythrocyte ghost membranes Journal of Biological Chemistry. 253: 8366-8368. PMID 711757  1
1978 Rottem S, Slutzky GM, Bittman R. Cholesterol distribution and movement in the mycoplasma gallisepticum cell membrane Biochemistry. 17: 2723-2726. PMID 210781  1
1978 Clejan S, Bittman R, Deroo PW, Rosenthal AF. Permeability properties of liposomes prepared from diacyl, dialkoxy, dialkyl and acyl-alkoxy phospholipids with and without cholesterol Annals of the New York Academy of Sciences. 441.  1
1977 Chen WC, Bittman R. Kinetics of association of amphotericin B with vesicles Biochemistry. 16: 4145-4149. PMID 901763  1
1977 Blau L, Bittman R. Interaction of filipin with cholesterol in vesicles of saturated phospholipids Biochemistry. 16: 4139-4144. PMID 901762  1
1977 Wun TC, Bittman R. Ionophorous properties of neutral diamide ligands toward calcium Biochemistry. 16: 2080-2086. PMID 861198  1
1977 Wun TC, Bittman R, Borowitz IJ. Binding properties of neutral diamide ligands for alkaline-earth cations Biochemistry. 16: 2074-2079. PMID 861197  1
1977 Majuk Z, Bittman R, Landsberger FR, Compans RW. Effects of filipin on the structure and biological activity of enveloped viruses Journal of Virology. 24: 883-892. PMID 201781  1
1976 Bittman R, Rottem S. Distribution of cholesterol between the outer and inner halves of the lipid bilayer of mycoplasma cell membranes Biochemical and Biophysical Research Communications. 71: 318-324. PMID 962923 DOI: 10.1016/0006-291X(76)90285-0  1
1976 Bittman R, Blau L. Kinetics of solute permeability in phospholipid vesicles Journal of Chemical Education. 53: 259-261. PMID 943404  1
1975 Blau L, Bittman R. Equilibrium and kinetic measurements of actinomycin binding to deoxyribonucleic acid in the presence of competing drugs Molecular Pharmacology. 11: 716-721. PMID 128690  1
1975 Bittman R, Blau L. Stopped-flow kinetic studies of actinomycin binding to DNAs Biochemistry. 14: 2138-2145. PMID 50082  1
1975 Rosenthol AF, Vargas LA, Isaacson YA, Bittman R. A simple synthesis of phosphonate - containing lipids. Introduction of the phosphonic acid moiety into hydrolytically-labile compounds Tetrahedron Letters. 16: 977-980. DOI: 10.1016/S0040-4039(00)72621-9  1
1974 Bittman R, Chen WC, Blau L. Stopped-flow kinetic and equilibrium studies of filipin III binding to sterols Biochemistry. 13: 1374-1379. PMID 4819754  1
1974 Bittman R. Analysis of reducing sugars in breakfast cereal and other foods: A general chemistry experiment Journal of Chemical Education. 51: 46-47. PMID 4815392  1
1974 Bittman R, Chen WC, Anderson OR. Interaction of filipin III and amphotericin B with lecithin-sterol vesicles and cellular membranes. Spectral and electron microscope studies Biochemistry. 13: 1364-1373. PMID 4132123  1
1972 Bittman R, Blau L. The phospholipid-cholesterol interaction. Kinetics of water permeability in liposomes Biochemistry. 11: 4831-4839. PMID 4655255  1
1972 Bittman R, Fischkoff SA. Fluorescence studies of the binding of the polyene antibiotics filipin 3, amphotericin B, nystatin, and lagosin to cholesterol Proceedings of the National Academy of Sciences of the United States of America. 69: 3795-3799. PMID 4509341  1
1969 Bittman R. Studies of the binding of ethidium bromide to transfer ribonucleic acid: Absorption, fluorescence, ultracentrifugation and kinetic investigations Journal of Molecular Biology. 46. PMID 4902518  1
1967 Streitwieser A, Verbit L, Bittman R. Stereochemistry of the primary carbon. XVI. Optically active 1-butanol-1-d by hydroboration Journal of Organic Chemistry. 32: 1530-1532.  1
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