Henry I. Mosberg - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Biochemistry

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Montgomery D, Anand JP, Griggs N, Fernandez TJ, Hartman JG, Sanchez-Santiago AA, Pogozheva ID, Traynor JR, Mosberg HI. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show In Vitro Kappa and Mu Opioid Receptor Agonism. Acs Chemical Neuroscience. PMID 31199621 DOI: 10.1021/acschemneuro.9b00250  0.52
2019 Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability  . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/acs.jmedchem.9b00219  0.4
2019 Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/acs.jmedchem.9b00378  0.4
2018 Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/acschemneuro.8b00139  0.4
2018 Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/bph.14148  0.4
2017 Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. Acs Chemical Neuroscience. PMID 28796483 DOI: 10.1021/acschemneuro.7b00284  0.52
2016 Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/acs.jmedchem.6b00308  1
2016 Anand JP, Boyer BT, Mosberg HI, Jutkiewicz EM. The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice. Psychopharmacology. PMID 27117141 DOI: 10.1007/s00213-016-4296-8  1
2015 Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. Acs Medicinal Chemistry Letters. 6: 1199-203. PMID 26713104 DOI: 10.1021/acsmedchemlett.5b00344  1
2015 Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/acs.jmedchem.5b01270  1
2015 Geng J, Pogozheva ID, Mosberg HI, Raghavan M. Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes. Journal of Immunology (Baltimore, Md. : 1950). 195: 3436-48. PMID 26324772 DOI: 10.4049/jimmunol.1500985  1
2015 Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/acschemneuro.5b00100  1
2014 Pogozheva ID, Mosberg HI, Lomize AL. Life at the border: adaptation of proteins to anisotropic membrane environment. Protein Science : a Publication of the Protein Society. 23: 1165-96. PMID 24947665 DOI: 10.1002/pro.2508  1
2014 Mosberg HI, Yeomans L, Anand JP, Porter V, Sobczyk-Kojiro K, Traynor JR, Jutkiewicz EM. Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. Journal of Medicinal Chemistry. 57: 3148-53. PMID 24641190 DOI: 10.1021/jm5002088  1
2014 Anand JP, Porter-Barrus VR, Waldschmidt HV, Yeomans L, Pogozheva ID, Traynor JR, Mosberg HI. Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers. 102: 107-14. PMID 24436042 DOI: 10.1002/bip.22437  1
2014 Ding B, Glukhova A, Sobczyk-Kojiro K, Mosberg HI, Tesmer JJ, Chen Z. Unveiling the membrane-binding properties of N-terminal and C-terminal regions of G protein-coupled receptor kinase 5 by combined optical spectroscopies. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 823-31. PMID 24401145 DOI: 10.1021/la404055a  1
2014 Bender AM, Clark MJ, Agius MP, Traynor JR, Mosberg HI. Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Bioorganic & Medicinal Chemistry Letters. 24: 548-51. PMID 24365161 DOI: 10.1016/j.bmcl.2013.12.021  1
2013 Pogozheva ID, Tristram-Nagle S, Mosberg HI, Lomize AL. Structural adaptations of proteins to different biological membranes. Biochimica Et Biophysica Acta. 1828: 2592-608. PMID 23811361 DOI: 10.1016/j.bbamem.2013.06.023  1
2013 Mosberg HI, Yeomans L, Harland AA, Bender AM, Sobczyk-Kojiro K, Anand JP, Clark MJ, Jutkiewicz EM, Traynor JR. Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands. Journal of Medicinal Chemistry. 56: 2139-49. PMID 23419026 DOI: 10.1021/jm400050y  1
2012 Anand JP, Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models. Chemical Biology & Drug Design. 80: 763-70. PMID 22882801 DOI: 10.1111/cbdd.12014  1
2012 Janovick JA, Pogozheva ID, Mosberg HI, Cornea A, Conn PM. Rescue of misrouted GnRHR mutants reveals its constitutive activity. Molecular Endocrinology (Baltimore, Md.). 26: 1179-88. PMID 22595961 DOI: 10.1210/me.2012-1089  1
2012 Lomize MA, Pogozheva ID, Joo H, Mosberg HI, Lomize AL. OPM database and PPM web server: resources for positioning of proteins in membranes. Nucleic Acids Research. 40: D370-6. PMID 21890895 DOI: 10.1093/nar/gkr703  1
2011 Girnys EA, Porter VR, Mosberg HI. Conformationally restricted analogs of the direct thrombin inhibitor FM 19. Bioorganic & Medicinal Chemistry. 19: 7425-34. PMID 22055408 DOI: 10.1016/j.bmc.2011.10.045  1
2011 Purington LC, Sobczyk-Kojiro K, Pogozheva ID, Traynor JR, Mosberg HI. Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide. Acs Chemical Biology. 6: 1375-81. PMID 21958158 DOI: 10.1021/cb200263q  1
2011 Janovick JA, Pogozheva ID, Mosberg HI, Conn PM. Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 338: 430-42. PMID 21527534 DOI: 10.1124/jpet.111.180869  1
2011 Lomize AL, Pogozheva ID, Mosberg HI. Anisotropic solvent model of the lipid bilayer. 1. Parameterization of long-range electrostatics and first solvation shell effects. Journal of Chemical Information and Modeling. 51: 918-29. PMID 21438609 DOI: 10.1021/ci2000192  1
2011 Lomize AL, Pogozheva ID, Mosberg HI. Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes. Journal of Chemical Information and Modeling. 51: 930-46. PMID 21438606 DOI: 10.1021/ci200020k  1
2010 René P, Le Gouill C, Pogozheva ID, Lee G, Mosberg HI, Farooqi IS, Valenzano KJ, Bouvier M. Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity. The Journal of Pharmacology and Experimental Therapeutics. 335: 520-32. PMID 20826565 DOI: 10.1124/jpet.110.172098  1
2010 Girnys EA, Sobczyk-Kojiro K, Mosberg HI. Structure-based design of residue 1 analogs of the direct thrombin inhibitor pentapeptide FM 19. Chemical Biology & Drug Design. 75: 35-9. PMID 19954432 DOI: 10.1111/j.1747-0285.2009.00915.x  1
2009 Purington LC, Pogozheva ID, Traynor JR, Mosberg HI. Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties. Journal of Medicinal Chemistry. 52: 7724-31. PMID 19788201 DOI: 10.1021/jm9007483  1
2009 Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. The Journal of Biological Chemistry. 284: 26732-41. PMID 19542234 DOI: 10.1074/jbc.M109.026922  1
2009 Roof RA, Roman DL, Clements ST, Sobczyk-Kojiro K, Blazer LL, Ota S, Mosberg HI, Neubig RR. A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen. Bmc Pharmacology. 9: 9. PMID 19463173 DOI: 10.1186/1471-2210-9-9  1
2009 Haskell-Luevano C, Xiang Z, Wilczynski AM, Haskell KR, Andreasen AM, Litherland SA, Millard WJ, Pogozheva ID, Mosberg HI, Sorenson NB. Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans. Advances in Experimental Medicine and Biology. 611: 509-10. PMID 19400288 DOI: 10.1007/978-0-387-73657-0_221  1
2009 Tan K, Pogozheva ID, Yeo GS, Hadaschik D, Keogh JM, Haskell-Leuvano C, O'Rahilly S, Mosberg HI, Farooqi IS. Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor. Endocrinology. 150: 114-25. PMID 18801902 DOI: 10.1210/en.2008-0721  1
2008 Proneth B, Pogozheva ID, Portillo FP, Mosberg HI, Haskell-Luevano C. Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity. Journal of Medicinal Chemistry. 51: 5585-93. PMID 18800761 DOI: 10.1021/jm800291b  1
2008 Roof RA, Sobczyk-Kojiro K, Turbiak AJ, Roman DL, Pogozheva ID, Blazer LL, Neubig RR, Mosberg HI. Novel peptide ligands of RGS4 from a focused one-bead, one-compound library. Chemical Biology & Drug Design. 72: 111-9. PMID 18637987 DOI: 10.1111/j.1747-0285.2008.00687.x  1
2008 Nieman MT, Burke F, Warnock M, Zhou Y, Sweigart J, Chen A, Ricketts D, Lucchesi BR, Chen Z, Di Cera E, Hilfinger J, Kim JS, Mosberg HI, Schmaier AH. Thrombostatin FM compounds: Direct thrombin inhibitors - Mechanism of action in vitro and in vivo Journal of Thrombosis and Haemostasis. 6: 837-845. PMID 18315550 DOI: 10.1111/j.1538-7836.2008.02937.x  1
2007 Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI. The role of hydrophobic interactions in positioning of peripheral proteins in membranes. Bmc Structural Biology. 7: 44. PMID 17603894 DOI: 10.1186/1472-6807-7-44  1
2007 Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C. Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms. Biochemistry. 46: 8273-87. PMID 17590021 DOI: 10.1021/bi7007382  1
2006 Burke FM, Warnock M, Schmaier AH, Mosberg HI. Synthesis of novel peptide inhibitors of thrombin-induced platelet activation. Chemical Biology & Drug Design. 68: 235-8. PMID 17177882 DOI: 10.1111/j.1747-0285.2006.00442.x  1
2006 Lomize AL, Pogozheva ID, Lomize MA, Mosberg HI. Positioning of proteins in membranes: a computational approach. Protein Science : a Publication of the Protein Society. 15: 1318-33. PMID 16731967 DOI: 10.1110/ps.062126106  1
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/j.1747-0285.2006.00373.x  1
2006 Proneth B, Xiang Z, Pogozheva ID, Litherland SA, Gorbatyuk OS, Shaw AM, Millard WJ, Mosberg HI, Haskell-Luevano C. Molecular mechanism of the constitutive activation of the L250Q human melanocortin-4 receptor polymorphism. Chemical Biology & Drug Design. 67: 215-29. PMID 16611215 DOI: 10.1111/j.1747-0285.2006.00362.x  1
2006 Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, Woods JH. Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. European Journal of Pharmacology. 531: 151-9. PMID 16442521 DOI: 10.1016/j.ejphar.2005.12.002  1
2006 Lomize MA, Lomize AL, Pogozheva ID, Mosberg HI. OPM: orientations of proteins in membranes database. Bioinformatics (Oxford, England). 22: 623-5. PMID 16397007 DOI: 10.1093/bioinformatics/btk023  1
2006 Torregrossa MM, Jutkiewicz EM, Mosberg HI, Balboni G, Watson SJ, Woods JH. Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats. Brain Research. 1069: 172-81. PMID 16364263 DOI: 10.1016/j.brainres.2005.11.005  1
2005 Pogozheva ID, Przydzial MJ, Mosberg HI. Homology modeling of opioid receptor-ligand complexes using experimental constraints. The Aaps Journal. 7: E434-48. PMID 16353922 DOI: 10.1208/aapsj070243  1
2005 Przydzial MJ, Pogozheva ID, Ho JC, Bosse KE, Sawyer E, Traynor JR, Mosberg HI. Design of high affinity cyclic pentapeptide ligands for kappa-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 255-62. PMID 16218993 DOI: 10.1111/j.1399-3011.2005.00295.x  1
2005 Pogozheva ID, Chai BX, Lomize AL, Fong TM, Weinberg DH, Nargund RP, Mulholland MW, Gantz I, Mosberg HI. Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists. Biochemistry. 44: 11329-41. PMID 16114870 DOI: 10.1021/bi0501840  1
2005 Przydzial MJ, Pogozheva ID, Bosse KE, Andrews SM, Tharp TA, Traynor JR, Mosberg HI. Roles of residues 3 and 4 in cyclic tetrapeptide ligand recognition by the kappa-opioid receptor. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 333-42. PMID 15787963 DOI: 10.1111/j.1399-3011.2005.00220.x  1
2005 Chai BX, Pogozheva ID, Lai YM, Li JY, Neubig RR, Mosberg HI, Gantz I. Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry. 44: 3418-31. PMID 15736952 DOI: 10.1021/bi0478704  1
2005 Jameson EE, Roof RA, Whorton MH, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues Journal of Biological Chemistry. 280: 7712-7719. PMID 15613467 DOI: 10.1074/jbc.M413810200  1
2004 Fowler CB, Pogozheva ID, Lomize AL, LeVine H, Mosberg HI. Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints. Biochemistry. 43: 15796-810. PMID 15595835 DOI: 10.1021/bi048413q  1
2004 Lomize AL, Pogozheva ID, Mosberg HI. Quantification of helix-helix binding affinities in micelles and lipid bilayers Protein Science. 13: 2600-2612. PMID 15340167 DOI: 10.1110/ps.04850804  1
2004 Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity. Methods in Enzymology. 389: 266-77. PMID 15313571 DOI: 10.1016/S0076-6879(04)89016-5  1
2004 Fowler CB, Pogozheva ID, LeVine H, Mosberg HI. Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites. Biochemistry. 43: 8700-10. PMID 15236578 DOI: 10.1021/bi036067r  1
2004 Jin Y, Zhong H, Omnaas JR, Neubig RR, Mosberg HI. Structure-based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors Journal of Peptide Research. 63: 141-146. PMID 15009535 DOI: 10.1111/j.1399-3011.2003.00114.x  1
2003 Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research. 20: 1381-8. PMID 14567631 DOI: 10.1023/A:1025745824632  1
2003 Ko MC, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN. Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. The Journal of Pharmacology and Experimental Therapeutics. 305: 173-9. PMID 12649366 DOI: 10.1124/jpet.102.044909  1
2002 Mosberg HI, Fowler CB. Development and validation of opioid ligand-receptor interaction models: The structural basis of mu vs. delta selectivity Journal of Peptide Research. 60: 329-335. PMID 12464111 DOI: 10.1034/j.1399-3011.2002.21061.x  1
2002 Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR. Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochemical and Biophysical Research Communications. 293: 1233-41. PMID 12054508 DOI: 10.1016/S0006-291X(02)00357-1  1
2002 Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR. NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. Biochemistry. 41: 3596-604. PMID 11888275 DOI: 10.1021/bi015811+  1
2001 Hicks ME, Gomez-Flores R, Wang C, Mosberg HI, Weber RJ. Differential effects of the novel non-peptidic opioid 4-tyrosylamido-6-benzyl-1,2,3,4 tetrahydroquinoline (CGPM-9) on in vitro rat t lymphocyte and macrophage functions Life Sciences. 68: 2685-2694. PMID 11405238 DOI: 10.1016/S0024-3205(01)01083-9  1
2000 McFadyen IJ, Sobczyk-Kojiro K, Schaefer MJ, Ho JC, Omnaas JR, Mosberg HI, Traynor JR. Tetrapeptide derivatives of [D-Pen(2),D-Pen(5)]-enkephalin (DPDPE) lacking an N-terminal tyrosine residue are agonists at the mu-opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 960-6. PMID 11082429  1
2000 McFadyen IJ, Ho JC, Mosberg HI, Traynor JR. Modifications of the cyclic mu receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]NH2 (Et): effects on opioid receptor binding and activation. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 255-61. PMID 10727108 DOI: 10.1034/j.1399-3011.2000.00177.x  1
1999 Mosberg HI. Complementarity of δ opioid ligand pharmacophore and receptor models Biopolymers - Peptide Science Section. 51: 426-439. PMID 10797231 DOI: 10.1002/(SICI)1097-0282(1999)51:6<426::AID-BIP5>3.0.CO;2-G  1
1999 Ko MC, Johnson MD, Butelman ER, Willmont KJ, Mosberg HI, Woods JH. Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 291: 1113-20. PMID 10565831  1
1999 Lomize AL, Pogozheva ID, Mosberg HI. Prediction of protein structure: The problem of fold multiplicity Proteins: Structure, Function and Genetics. 37: 199-203. PMID 10526369 DOI: 10.1002/(SICI)1097-0134(1999)37:3+<199::AID-PROT25>3.0.CO;2-Y  1
1999 Johnson MD, Ko M, Choo KS, Traynor JR, Mosberg HI, Naughton NN, Woods JH. The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats. Brain Research. 839: 194-8. PMID 10482814 DOI: 10.1016/S0006-8993(99)01708-4  1
1999 Lomize AL, Pogozheva ID, Mosberg HI. Structural organization of G-protein-coupled receptors Journal of Computer-Aided Molecular Design. 13: 325-353. PMID 10425600 DOI: 10.1023/A:1008050821744  1
1999 Ma W, Mosberg HI. Synthesis of 6- or 7-substituted 1,2,3,4-tetrahydroisoquinoline-3- carboxylic acids International Journal of Peptide Research and Therapeutics. 6: 179-183.  1
1998 Wang C, McFadyen IJ, Traynor JR, Mosberg HI. Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models. Bioorganic & Medicinal Chemistry Letters. 8: 2685-8. PMID 9873603 DOI: 10.1016/S0960-894X(98)00472-7  1
1998 Mosberg HI, Ho JC, Sobczyk-Kojiro K. A high affinity, Mu-opioid receptor-selective enkephalin analogue lacking an N-terminal tyrosine Bioorganic and Medicinal Chemistry Letters. 8: 2681-2684. PMID 9873602 DOI: 10.1016/S0960-894X(98)00476-4  1
1998 Pogozheva ID, Lomize AL, Mosberg HI. Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints Biophysical Journal. 75: 612-634. PMID 9675164  1
1998 Butelman ER, Ko MC, Sobczyk-Kojiro K, Mosberg HI, Van Bemmel B, Zernig G, Woods JH. kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception. The Journal of Pharmacology and Experimental Therapeutics. 285: 595-601. PMID 9580603  1
1997 Lomize AL, Mosberg HI. Thermodynamic model of secondary structure for α-helical peptides and proteins Biopolymers. 42: 239-269. PMID 9235002 DOI: 10.1002/(SICI)1097-0282(199708)42:2<239::AID-BIP12>3.0.CO;2-G  1
1997 Pogozheva ID, Lomize AL, Mosberg HI. The transmembrane 7-α-bundle of rhodopsin: Distance geometry calculations with hydrogen bonding constraints Biophysical Journal. 72: 1963-1985. PMID 9129801  1
1997 Mansour A, Taylor LP, Fine JL, Thompson RC, Hoversten MT, Mosberg HI, Watson SJ, Akil H. Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Journal of Neurochemistry. 68: 344-53. PMID 8978745  1
1996 Jewett DC, Mosberg HI, Woods JH. Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons. Psychopharmacology. 127: 225-30. PMID 8912400 DOI: 10.1007/s002130050080  1
1996 Mosberg HI, Dua RK, Pogozheva ID, Lomize AL. Development of a model for the δ-opioid receptor pharmacophore. 4. Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM- 13) confirm required gauche orientation of aromatic side chain Biopolymers. 39: 287-296. PMID 8756510 DOI: 10.1002/(SICI)1097-0282(199609)39:3<287::AID-BIP2>3.0.CO;2-K  1
1996 Lomize AL, Pogozheva ID, Mosberg HI. Development of a model for the δ-opioid receptor pharmacophore: 3. Comparison of the cyclic tetrapeptide, Tyr-c [D-Cys-Phe-D-Pen] OH with other conformationally constrained δ-receptor selective ligands Biopolymers. 38: 221-234. PMID 8589255  1
1995 Chenguang Wang, Mosberg HI. Synthesis of a novel series of topographically constrained amino acids: Benzo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids Tetrahedron Letters. 36: 3623-3626. DOI: 10.1016/0040-4039(95)00617-L  1
1994 Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6  1
1994 Mosberg HI, Omnaas JR, Lomize A, Heyl DL, Nordan I, Mousigian C, Davis P, Porreca F. Development of a model for the δ opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the Cyclic δ receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) Journal of Medicinal Chemistry. 37: 4384-4391. PMID 7996550  1
1994 Mosberg HI, Lomize AL, Wang C, Kroona H, Heyl DL, Sobczyk-Kojiro K, Ma W, Mousigian C, Porreca F. Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13). Journal of Medicinal Chemistry. 37: 4371-83. PMID 7996549  1
1994 Mosberg HI, Omnaas JR, Sobczyk-Kojiro K, Dua R, Ho JC, Ma W, Bush P, Mousigian C, Lomize A. Pharmacophore elements of the TIPP class of delta opioid receptor antagonists Letters in Peptide Science. 1: 69-72. DOI: 10.1007/BF00126275  1
1994 Lomize AL, Flippen-Anderson JL, George C, Mosberg HI. Conformational analysis of the δ receptor-selective, cyclic opioid peptide, Tyr-cyclo[D-Cys-Phe-D-Pen]OH (JOM-13). Comparison of X-ray crystallographic structures, molecular mechanics simulations, and 1H NMR data Journal of the American Chemical Society. 116.  1
1993 Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic parameters for [D-Pen2,5]enkephalin at δ-opioid receptors in the mouse isolated vas deferens European Journal of Pharmacology: Molecular Pharmacology. 244: 231-238. PMID 8384567 DOI: 10.1016/0922-4106(93)90148-3  1
1993 Wild KD, Carlisi VJ, Mosberg HI, Bowen WD, Portoghese PS, Sultana M, Takemori AE, Hruby VJ, Porreca F. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens. The Journal of Pharmacology and Experimental Therapeutics. 264: 831-8. PMID 8382281  1
1993 Mosberg HI, Porreca F. A model for the structural basis of delta 2-opioid receptor selectivity Nida Research Monograph. 134: 268-280. PMID 8289883  1
1993 Comer SD, Hoenicke EM, Sable AI, McNutt RW, Chang KJ, De Costa BR, Mosberg HI, Woods JH. Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice. The Journal of Pharmacology and Experimental Therapeutics. 267: 888-95. PMID 8246164  1
1993 Comer SD, McNutt RW, Chang KJ, De Costa BR, Mosberg HI, Woods JH. Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 866-74. PMID 8246161  1
1993 Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Hruby VJ, Mosberg HI, Porreca F. Modulation of morphine antinociception by swim-stress in the mouse: involvement of supraspinal opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 267: 449-55. PMID 8229774  1
1993 Nanjappan P, Ramalingam K, Mosberg HI, Woodard RW. Syntheses of (2S,3S)-[4,4,4-2H3]- and (2S,3R)-[4,4,4-2H3]Penicillamine Synthesis. 421-425.  1
1992 Bai JPF, Hu M, Subramanian P, Mosberg HI, Amidon GL. Utilization of peptide carrier system to improve intestinal absorption: Targeting prolidase as a prodrug-converting enzyme Journal of Pharmaceutical Sciences. 81: 113-116. PMID 1545347  1
1992 DeLander GE, Mosberg HI, Porreca F. Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: Dissociation from gastrointestinal effects in mice Journal of Pharmacology and Experimental Therapeutics. 263: 1097-1104. PMID 1335055  1
1992 Raffa RB, Wild KD, Mosberg HI, Porreca F. Thermodynamic analysis of the temperature dependence of the dissociation constant of naloxone at opioid delta receptors in the mouse isolated vas deferens Journal of Pharmacology and Experimental Therapeutics. 263: 1030-1035. PMID 1335052  1
1992 Mosberg HI, Kroona HB. Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, δ opioid receptor selective tetrapeptide (JOM-13) enhances δ receptor binding affinity and selectivity Journal of Medicinal Chemistry. 35: 4498-4500. PMID 1333014  1
1992 Heyl DL, Mosberg HI. Modification of the Phe3 aromatic moiety in delta receptor-selective dermorphin/deltorphin-related tetrapeptides. Effects on opioid receptor binding International Journal of Peptide and Protein Research. 39: 450-457. PMID 1330964  1
1992 Porreca F, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI. Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 263: 147-52. PMID 1328602  1
1992 Vanderah TW, Wild KD, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics. 262: 190-7. PMID 1320682  1
1992 Heyl DL, Mosberg HI. Substitution on the Phe3 aromatic ring in cyclic δ opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: Electronic and lipophilic requirements for receptor affinity Journal of Medicinal Chemistry. 35: 1535-1541. PMID 1315870  1
1992 Hansen DW, Stapelfeld A, Savage MA, Reichman M, Hammond DL, Haaseth RC, Mosberg HI. Systemic analgesic activity and δ-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin Journal of Medicinal Chemistry. 35: 684-687. PMID 1311764  1
1992 Mattia A, Farmer SC, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Bowen WD, Porreca F. Spinal opioid delta antinociception in the mouse: mediation by a 5'-NTII-sensitive delta receptor subtype. The Journal of Pharmacology and Experimental Therapeutics. 260: 518-25. PMID 1310737  1
1991 Bai PF, Subramanian P, Mosberg HI, Amidon GL. Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino Group Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 593-599. PMID 1866373 DOI: 10.1023/A:1015848522228  1
1991 Heyl DL, Omnaas JR, Sobczyk-Kojiro K, Medzihradsky F, Smith CB, Mosberg HI. Opioid receptor affinity and selectivity effects of second residue and carboxy terminal residue variation in a cyclic disulfide-containing opioid tetrapeptide. International Journal of Peptide and Protein Research. 37: 224-9. PMID 1651290  1
1991 Mattia A, Vanderah T, Mosberg HI, Porreca F. Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin ii in mice: Evidence for delta receptor subtypes Journal of Pharmacology and Experimental Therapeutics. 258: 583-87. PMID 1650835  1
1991 Mattia A, Vanderah T, Mosberg HI, Omnaas JR, Bowen WD, Porreca F. Pharmacological characterization of [D-Ala2,Leu5,Ser6]enkephalin (DALES): antinociceptive actions at the δnon-complexed-opioid receptor European Journal of Pharmacology. 192: 371-375. PMID 1647317 DOI: 10.1016/0014-2999(91)90227-H  1
1991 Wild KD, Vanderah T, Mosberg HI, Porreca F. Opioid δ receptor subtypes are associated with different potassium channels European Journal of Pharmacology. 193: 135-136. PMID 1646729 DOI: 10.1016/0014-2999(91)90215-C  1
1991 Jiang Q, Takemori AE, Sultana M, Portoghese PS, Bowen WD, Mosberg HI, Porreca F. Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes. The Journal of Pharmacology and Experimental Therapeutics. 257: 1069-75. PMID 1646319  1
1990 Sheldon RJ, Riviere PJM, Malarchik ME, Mosberg HI, Burks TF, Porreca F. Opioid regulation of mucosal ion transport in the mouse isolated jejunum Journal of Pharmacology and Experimental Therapeutics. 253: 144-151. PMID 2329501  1
1990 Qi J, Mosberg HI, Porreca F. Selective modulation of morphine antinociception, but not development of tolerance, by δ receptor agonists European Journal of Pharmacology. 186: 137-141. PMID 2178093 DOI: 10.1016/0014-2999(90)94071-5  1
1990 Haaseth RC, Sobczyk-Kojiro K, Medzihradsky F, Smith CB, Mosberg HI. Single residue modifications of the delta opioid receptor selective peptide, [D-Pen2,D-Pen5]-enkephalin (DPDPE). Correlation of pharmacological effects with structural and conformational features. International Journal of Peptide and Protein Research. 36: 139-46. PMID 2177042  1
1990 Mosberg HI, Heyl DL, Haaseth RC, Omnaas JR, Medzihradsky F, Smith CB. Cyclic dermorphin-like tetrapeptides with delta-opioid receptor selectivity. 3. Effect of residue 3 modification on in vitro opioid activity. Molecular Pharmacology. 38: 924-8. PMID 2174509  1
1990 Jiang Q, Bowen WD, Mosberg HI, Rothman RB, Porreca F. Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: Selective actions at the delta(noncomplexed) site Journal of Pharmacology and Experimental Therapeutics. 255: 636-641. PMID 2173752  1
1990 Jiang Q, Mosberg HI, Porreca F. Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective δ agonist in vivo Life Sciences. 47. PMID 2170791 DOI: 10.1016/0024-3205(90)90545-3  1
1990 Jiang Q, Mosberg HI, Porreca F. Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse Journal of Pharmacology and Experimental Therapeutics. 254: 683-689. PMID 2166801  1
1990 Jiang Q, Mosberg HI, Porreca F. Modulation of the analgesic efficacy and potency of morphine by [D-Pen2, D-Pen5]enkephalin in mice Progress in Clinical and Biological Research. 328: 449-452. PMID 2154803  1
1990 Mosberg HI, Sobczyk-Kojiro K, Subramanian P, Crippen GM, Ramalingam K, Woodard RW. Combined use of stereospecific deuteration, NMR, distance geometry, and energy minimization for the conformational analysis of the highly δ opioid receptor selective peptide [D-Pen2,D-Pen5]enkephalin Journal of the American Chemical Society. 112: 822-829.  1
1989 Hu M, Subramanian P, Mosberg HI, Amidon GL. Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 66-70. PMID 2717522 DOI: 10.1023/A:1015855820488  1
1989 Heyman JS, Jiang Q, Rothman RB, Mosberg HI, Porreca F. Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists European Journal of Pharmacology. 169: 43-52. PMID 2557223 DOI: 10.1016/0014-2999(89)90815-7  1
1989 Heyman JS, Vaught JL, Mosberg HI, Haaseth RC, Porreca F. Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin European Journal of Pharmacology. 165: 1-10. PMID 2548877 DOI: 10.1016/0014-2999(89)90764-4  1
1988 Cowan A, Zhu XZ, Mosberg HI, Omnaas JR, Porreca F. Direct dependence studies in rats with agents selective for different types of opioid receptor Journal of Pharmacology and Experimental Therapeutics. 246: 950-955. PMID 2901490  1
1988 Tortella FC, Echevarria E, Robles L, Mosberg HI, Holaday JW. Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats Peptides. 9: 1177-1181. PMID 2854247 DOI: 10.1016/0196-9781(88)90104-0  1
1988 Mosberg HI, Haaseth RC, Ramalingam K, Mansour A, Akil H, Woodard RW. Role of steric interactions in the delta opioid receptor selectivity of [D-Pen2, D-Pen5]enkephalin. International Journal of Peptide and Protein Research. 32: 1-8. PMID 2851561  1
1988 Mosberg HI, Omnaas JR, Medzihradsky F, Smith CB. Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high delta opioid receptor selectivity and affinity. Life Sciences. 43: 1013-20. PMID 2845204 DOI: 10.1016/0024-3205(88)90547-4  1
1988 Heyman JS, Williams CL, Burks TF, Mosberg HI, Porreca F. Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: Studies with naloxonazine Journal of Pharmacology and Experimental Therapeutics. 245: 238-243. PMID 2834537  1
1987 Mosberg HI. 1H-n.m.r. investigation of conformational features of cyclic, penicillamine-containing enkephalin analogs International Journal of Peptide and Protein Research. 29: 282-288. PMID 3570668  1
1987 Mosberg HI, Omnaas JR, Goldstein A. Structural requirements for δ opioid receptor binding Molecular Pharmacology. 31: 599-602. PMID 3037296  1
1987 Porreca F, Heyman JS, Mosberg HI, Omnaas JR, Vaught JL. Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]Enkephalin in the mouse Journal of Pharmacology and Experimental Therapeutics. 241: 393-400. PMID 3033214  1
1987 Porreca F, Mosberg HI, Omnaas JR, Burks TF, Cowan A. Supraspinal and spinal potency of selective opioid agonists in the mouse writhing test Journal of Pharmacology and Experimental Therapeutics. 240: 890-894. PMID 3031278  1
1987 Tortella FC, Robles L, Mosberg HI. Evidence of Mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures Journal of Pharmacology and Experimental Therapeutics. 240: 571-577. PMID 3027318  1
1987 Heyman JS, Mulvaney SA, Mosberg HI, Porreca F. Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain Research. 420: 100-8. PMID 2823970 DOI: 10.1016/0006-8993(87)90244-7  1
1987 Mosberg HI, Omnaas JR, Ramalingam K, Woodard RW. Synthesis of deuterium labelled penicillamine and its use for the assignment of the 1H NMR spectra of two cyclic enkephalin analogs Journal of Labelled Compounds and Radiopharmaceuticals. 24: 1265-1271.  1
1986 Heyman JS, Koslo RJ, Mosberg HI, Tallarida RJ, Porreca F. Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists Life Sciences. 39: 1795-1803. PMID 3022095 DOI: 10.1016/0024-3205(86)90099-8  1
1986 Cowan A, Zhu XZ, Mosberg HI, Porreca F. Central infusion of rats with agents selective for different types of opioid receptor Nida Research Monograph Series. 132-137. PMID 3018570  1
1986 Spencer RL, Deupree D, Hsiao S, Mosberg HI, Hruby V, Burks TF, Porreca F. Centrally-administered opioid selective agonists inhibit drinking in the rat Pharmacology, Biochemistry and Behavior. 25: 77-82. PMID 2875475 DOI: 10.1016/0091-3057(86)90233-9  1
1986 Heyman JS, Mosberg HI, Porreca F. Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice Nida Research Monograph. 75: 442-445. PMID 2828989  1
1985 Gulya K, Gehlert DR, Wamsley JK, Mosberg HI, Hruby VJ, Duckles SP, Yamamura HI. Autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog. European Journal of Pharmacology. 111: 285-6. PMID 2990955 DOI: 10.1016/0014-2999(85)90770-8  1
1985 Hirning LD, Mosberg HI, Hurst R, Hruby VJ, Burks TF, Porreca F. Studies in vitro with ICI 174, 864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO) Neuropeptides. 5: 383-386. PMID 2987739 DOI: 10.1016/0143-4179(85)90034-4  1
1985 Akiyama K, Gee KW, Mosberg HI, Hruby VJ, Yamamura HI. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proceedings of the National Academy of Sciences of the United States of America. 82: 2543-7. PMID 2986120  1
1985 Mosberg HI, Omnaas JR. Dithioether-containing cyclic peptides Journal of the American Chemical Society. 107: 2986-2987.  1
1985 Porreca F, Burks TF, Mosberg HI, Cowan A. Potency of supraspinal & spinal selective opioids in the mouse writhing test Federation Proceedings. 44.  1
1985 Tortella FC, Robles L, Mosberg HI, Holaday JW. Mu (DAGO) but not delta (DPDPE or DPLPE) opioids induce nonconvulsive EEG seizures in rats Federation Proceedings. 44.  1
1984 Mosberg HI, Schiller PW. 1H n.m.r. investigation of conformational features of cyclic enkephalinamide analogs International Journal of Peptide and Protein Research. 23: 462-466. PMID 6735586  1
1984 Galligan JJ, Mosberg HI, Hurst R, Hruby VJ, Burks TF. Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids. The Journal of Pharmacology and Experimental Therapeutics. 229: 641-8. PMID 6327967  1
1984 Tortella FC, Robles L, Mosberg HI, Holaday JW. Electroencephalographic assessment of the role of δ receptors in opioid peptide - induced seizures Neuropeptides. 5: 213-216. PMID 6099500 DOI: 10.1016/0143-4179(84)90065-9  1
1984 Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF. Roles of Mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse Journal of Pharmacology and Experimental Therapeutics. 230: 341-348. PMID 6086883  1
1984 Burke TF, Mosberg HI, Hurst R. Spinal and supraspinal mediation of analgesia in the mouse Federation Proceedings. 43.  1
1983 Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF. A comparison of the analgesic and gastrointestinal transit effects of [D-Pen2, L-Cys5] enkephalin after intracerebroventricular and intrathecal administration to mice Life Sciences. 33: 457-460. PMID 6689355 DOI: 10.1016/0024-3205(83)90540-4  1
1983 Hruby VJ, Mosberg HI, Sawyer TK, Knittel JJ, Rockway TW, Ormberg J, Darman P, Chan WY, Hadley ME. Conformational and dynamic considerations in the design of peptide hormone analogs Biopolymers. 22: 517-530. PMID 6673771  1
1983 Mosberg HI, Hurst R, Hruby VJ, Gee K, Akiyama K, Yamamura HI, Galligan JJ, Burks TF. Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities. Life Sciences. 33: 447-50. PMID 6319901 DOI: 10.1016/0024-3205(83)90538-6  1
1983 Mosberg HI, Hurst R, Hruby VJ, Gee K, Yamamura HI, Galligan JJ, Burks TF. Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. Proceedings of the National Academy of Sciences of the United States of America. 80: 5871-4. PMID 6310598  1
1983 Mosberg HI, Hurst R, Hruby VJ, Galligan JJ, Burks TF, Gee K, Yamamura HI. Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity. Life Sciences. 32: 2565-9. PMID 6304440 DOI: 10.1016/0024-3205(83)90239-4  1
1982 Hruby VJ, Mosberg HI. Conformational and dynamic considerations in peptide structure-function studies Peptides. 3: 329-336. PMID 7122270 DOI: 10.1016/0196-9781(82)90095-X  1
1982 Hruby VJ, Mosberg HI, Fox JW, Tu AT. Conformational comparisons of oxytocin agonists, partial agonists, and antagonists using laser raman and circular dichroism spectroscopy. Examination of 1-penicillamine and diastereoisomeric analogues Journal of Biological Chemistry. 257: 4916-4924. PMID 7068672  1
1982 Mosberg HI, Hurst R, Hruby VJ, Galligan JJ, Burks TF, Gee K, Yamamura HI. [D-Pen2, L-Cys5]enkephalinamide and[D-Pen2, D-Cys5] enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity. Biochemical and Biophysical Research Communications. 106: 506-12. PMID 6285922 DOI: 10.1016/0006-291X(82)91139-1  1
1982 Mosberg HI. Long range spin-spin coupling as an aid for the assignment of aromatic residues in peptide 1H NMR spectra Biopolymers. 21: 2483-2486.  1
1982 Hruby VJ, Mosberg HI, Viswanatha V. Active-site studies of neurohypophyseal hormones: Comparison of oxytocin and arginine-vasopressin with analogues containing 4-D-glutamine Journal of the American Chemical Society. 104: 837-841.  1
1981 Mosberg HI, Hruby VJ, Meraldi JP. Conformational study of the potent peptide hormone antagonist [1-penicillamine,2-leucine]oxytocin in aqueous solution Biochemistry. 20: 2822-2828. PMID 7248250  1
1981 Fox JA, Tu AT, Hruby VJ, Mosberg HI. Raman study of crystalline peptides containing β turns Archives of Biochemistry and Biophysics. 211: 628-631. PMID 6171202 DOI: 10.1016/0003-9861(81)90498-7  1
1980 Mosberg HI, Scogin DA, Storm DR, Gennis RB. Proton nuclear magnetic resonance studies on bacitracin A and its interaction with zinc ion Biochemistry. 19: 3353-3357. PMID 7407048  1
1980 Scogin DA, Mosberg HI, Storm DR, Gennis RB. Binding of nickel and zinc ions to bacitracin A Biochemistry. 19: 3348-3352. PMID 7407047  1
1980 Hruby VJ, Mosberg HI, Hadley ME, Chan WY, Powell AM. Synthesis, pharmacological, conformational, and dynamic studies of the potent hormone antagonists [1-penicillamine, 4-threonine]-oxytocin and [1-penicillamine, 2-phenylalanine, 4-threonine]-oxytocin. Conformational and dynamic considerations in the design of antagonists International Journal of Peptide and Protein Research. 16: 372-381. PMID 7216613  1
1976 Mosberg HI, Beard CB, Schmidt PG. 1H NMR of succinate binding to aspartate transcarbamylase a comparison of results in D2O and H2O Biophysical Chemistry. 6: 1-8. PMID 13874 DOI: 10.1016/0301-4622(76)80055-5  1
1975 Mosberg HI, Schmidt PG, Seaver SS. Specifically deuterated l-malate as an NMR probe of the aspartate transcarbamylase catalytic site Journal of Magnetic Resonance (1969). 20: 82-88. DOI: 10.1016/0022-2364(75)90152-3  1
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