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Ronald D. Gorham, Ph.D. - Publications

Affiliations: 
2013 Bioengineering University of California, Riverside, Riverside, CA, United States 
Area:
Biomedical Engineering, General Biophysics, Bioinformatics Biology, Pharmacy
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Narkhede YB, Gautam AK, Hsu RV, Rodriguez W, Zewde NT, Harrison RES, Arantes PR, Gaieb Z, Gorham RD, Kieslich C, Morikis D, Sahu A, Palermo G. Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition. Frontiers in Molecular Biosciences. 8: 618068. PMID 33829039 DOI: 10.3389/fmolb.2021.618068  0.743
2018 Mohan RR, Wilson M, Gorham RD, Harrison RES, Morikis VA, Kieslich CA, Orr AA, Coley AV, Tamamis P, Morikis D. Virtual Screening of Chemical Compounds for Discovery of Complement C3 Ligands. Acs Omega. 3: 6427-6438. PMID 30221234 DOI: 10.1021/acsomega.8b00606  0.733
2018 Zwarthoff SA, Berends ETM, Mol S, Ruyken M, Aerts PC, Józsi M, de Haas CJC, Rooijakkers SHM, Gorham RD. Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models. Frontiers in Immunology. 9: 1691. PMID 30083158 DOI: 10.3389/Fimmu.2018.01691  0.336
2018 Praest P, Luteijn RD, Brak-Boer IGJ, Lanfermeijer J, Hoelen H, Ijgosse L, Costa AI, Gorham RD, Lebbink RJ, Wiertz EJHJ. The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins. Molecular Immunology. 101: 55-64. PMID 29879547 DOI: 10.1016/J.Molimm.2018.05.025  0.328
2017 Harrison RES, Mohan RR, Gorham RD, Kieslich CA, Morikis D. AESOP: A Python Library for Investigating Electrostatics in Protein Interactions. Biophysical Journal. 112: 1761-1766. PMID 28494947 DOI: 10.1016/J.Bpj.2017.04.005  0.756
2016 Mohan RR, Cabrera AP, Harrison RE, Gorham RD, Johnson LV, Ghosh K, Morikis D. Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. Molecular Vision. 22: 1280-1290. PMID 27829783  0.507
2016 Zewde N, Gorham RD, Dorado A, Morikis D. Quantitative Modeling of the Alternative Pathway of the Complement System. Plos One. 11: e0152337. PMID 27031863 DOI: 10.1371/Journal.Pone.0152337  0.575
2016 Koymans KJ, Vrieling M, Gorham RD, van Strijp JA. Staphylococcal Immune Evasion Proteins: Structure, Function, and Host Adaptation. Current Topics in Microbiology and Immunology. PMID 26919864 DOI: 10.1007/82_2015_5017  0.322
2016 Harrison RE, Gorham RD, Morikis D. Synergy of Putative Binding Modes in the Factor H (CCP 19-20) and C3d Complex Biophysical Journal. 110: 44a. DOI: 10.1016/J.Bpj.2015.11.303  0.639
2015 Gorham RD, Nunez V, Lin JH, Rooijakkers SH, Vullev VI, Morikis D. Discovery of small molecules for fluorescent detection of complement activation product C3d. Journal of Medicinal Chemistry. PMID 26613117 DOI: 10.1021/Acs.Jmedchem.5B01062  0.618
2015 Berends ET, Gorham RD, Ruyken M, Soppe JA, Orhan H, Aerts PC, de Haas CJ, Gros P, Rooijakkers SH. Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes. Bmc Biology. 13: 93. PMID 26552476 DOI: 10.1186/S12915-015-0203-8  0.347
2015 Chen CZ, Gorham RD, Gaieb Z, Morikis D. Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob. Molecular Biology International. 2015: 967465. PMID 26357573 DOI: 10.1155/2015/967465  0.654
2015 Bennett KM, Gorham RD, Gusti V, Trinh L, Morikis D, Lo DD. Hybrid flagellin as a T cell independent vaccine scaffold. Bmc Biotechnology. 15: 71. PMID 26265529 DOI: 10.1186/s12896-015-0194-0  0.501
2015 E S Harrison R, Gorham RD, Morikis D. Energetic evaluation of binding modes in the C3d and Factor H (CCP 19-20) complex. Protein Science : a Publication of the Protein Society. 24: 789-802. PMID 25628052 DOI: 10.1002/Pro.2650  0.647
2015 Gorham RD, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics. Journal of Medicinal Chemistry. 58: 814-26. PMID 25494040 DOI: 10.1021/Jm501345Y  0.604
2015 Mohan RR, Gorham RD, Morikis D. A theoretical view of the C3d:CR2 binding controversy. Molecular Immunology. 64: 112-22. PMID 25433434 DOI: 10.1016/J.Molimm.2014.11.006  0.611
2015 Bennett KM, Gorham RD, Gusti V, Trinh L, Morikis D, Lo DD. Hybrid flagellin as a T cell independent vaccine scaffold Bmc Biotechnology. 15. DOI: 10.1186/s12896-015-0194-0  0.462
2014 Ojha H, Panwar HS, Gorham RD, Morikis D, Sahu A. Viral regulators of complement activation: structure, function and evolution. Molecular Immunology. 61: 89-99. PMID 24976595 DOI: 10.1016/J.Molimm.2014.06.004  0.574
2014 Gorham RD, Rodriguez W, Morikis D. Molecular analysis of the interaction between staphylococcal virulence factor Sbi-IV and complement C3d. Biophysical Journal. 106: 1164-73. PMID 24606940 DOI: 10.1016/J.Bpj.2014.01.033  0.638
2013 Gorham RD, Forest DL, Tamamis P, López de Victoria A, Kraszni M, Kieslich CA, Banna CD, Bellows-Peterson ML, Larive CK, Floudas CA, Archontis G, Johnson LV, Morikis D. Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures. Experimental Eye Research. 116: 96-108. PMID 23954241 DOI: 10.1016/J.Exer.2013.07.023  0.742
2013 El-Assaad AM, Kieslich CA, Gorham RD, Morikis D. Erratum to “Electrostatic exploration of the C3d–FH4 interaction using a computational alanine scan” [Mol. Immunol. 48 (2011) 1844–1850] Molecular Immunology. 53: 173-174. DOI: 10.1016/J.Molimm.2012.07.006  0.694
2012 Tamamis P, López de Victoria A, Gorham RD, Bellows-Peterson ML, Pierou P, Floudas CA, Morikis D, Archontis G. Molecular dynamics in drug design: new generations of compstatin analogs. Chemical Biology & Drug Design. 79: 703-18. PMID 22233517 DOI: 10.1111/J.1747-0285.2012.01324.X  0.641
2012 Gorham RD, Urbanus RT, Kuipers A, Morikis D, Rooijakkers SH. Formation of an immune complex resembling C5b-9 via coagulation factors and platelets Immunobiology. 217: 1171-1172. DOI: 10.1016/J.Imbio.2012.08.123  0.536
2012 de Victoria AL, Tamamis P, Gorham RD, Kieslich CA, Bellows-Peterson ML, Floudas CA, Archontis G, Morikis D. Computational and Experimental Analysis of the Interactions Between C3 and Compstatin Family Peptides Biophysical Journal. 102: 62a. DOI: 10.1016/J.Bpj.2011.11.371  0.751
2012 Gorham RD, Kieslich CA, Morikis D. CompleMent Inhibition by Staphylococcus aureus: Electrostatics of C3d-EfbC and C3d-Ehp association Cellular and Molecular Bioengineering. 5: 32-43. DOI: 10.1007/S12195-011-0195-6  0.742
2011 El-Assaad AM, Kieslich CA, Gorham RD, Morikis D. Electrostatic exploration of the C3d-FH4 interaction using a computational alanine scan. Molecular Immunology. 48: 1844-50. PMID 21683447 DOI: 10.1016/J.Molimm.2011.05.007  0.775
2011 Gorham RD, Kieslich CA, Nichols A, Sausman NU, Foronda M, Morikis D. An evaluation of Poisson-Boltzmann electrostatic free energy calculations through comparison with experimental mutagenesis data. Biopolymers. 95: 746-54. PMID 21538330 DOI: 10.1002/Bip.21644  0.75
2011 López de Victoria A, Gorham RD, Bellows-Peterson ML, Ling J, Lo DD, Floudas CA, Morikis D. A new generation of potent complement inhibitors of the Compstatin family. Chemical Biology & Drug Design. 77: 431-40. PMID 21352502 DOI: 10.1111/J.1747-0285.2011.01111.X  0.621
2011 Gorham RD, Kieslich CA, Morikis D. Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization. Annals of Biomedical Engineering. 39: 1252-63. PMID 21140293 DOI: 10.1007/S10439-010-0226-9  0.769
2011 Kieslich CA, Gorham RD, Morikis D. Is the rigid-body assumption reasonable?: Insights into the effects of dynamics on the electrostatic analysis of barnase-barstar Journal of Non-Crystalline Solids. 357: 707-716. DOI: 10.1016/J.Jnoncrysol.2010.05.087  0.748
2011 Hakkoymaz H, Kieslich CA, Gorham RD, Gunopulos D, Morikis D. Electrostatic similarity determination using multiresolution analysis Molecular Informatics. 30: 733-746. DOI: 10.1002/minf.201100002  0.699
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