Lusong Luo, Ph.D. - Publications

Affiliations: 
2000 University of New Mexico, Albuquerque, NM, United States 
Area:
Biochemistry

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Guo Y, Liu Y, Hu N, Yu D, Zhou C, Shi G, Zhang B, Wei M, Liu J, Luo L, Tang Z, Song H, Guo Y, Liu X, Su D, et al. Discovery of Zanubrutinib (BGB-3111), a Novel, Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. Journal of Medicinal Chemistry. PMID 31381333 DOI: 10.1021/acs.jmedchem.9b00687  0.56
2016 Xu Z, Xu X, O'Laoi R, Ma H, Zheng J, Chen S, Luo L, Hu Z, He S, Li J, Zhang H, Zhang X. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold. Bioorganic & Medicinal Chemistry. PMID 27692509 DOI: 10.1016/j.bmc.2016.09.041  0.84
2015 Tang Z, Yuan X, Du R, Cheung SH, Zhang G, Wei J, Zhao Y, Feng Y, Peng H, Zhang Y, Du Y, Hu X, Gong W, Liu Y, Gao Y, ... ... Luo L, et al. BGB-283, a Novel RAF Kinase and EGFR inhibitor, Displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. Molecular Cancer Therapeutics. PMID 26208524 DOI: 10.1158/1535-7163.MCT-15-0262  0.84
2015 Yang Z, Ma H, Sun Z, Luo L, Tian S, Zheng J, Zhang X. Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 26119500 DOI: 10.1016/j.bmcl.2015.06.049  0.84
2012 Zhao H, Lim K, Choudry A, Latham JA, Pathak MC, Dominguez D, Luo L, Herzberg O, Dunaway-Mariano D. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry. 51: 6490-2. PMID 22871024 DOI: 10.1021/bi300968n  0.84
2011 Pappalardi MB, McNulty DE, Martin JD, Fisher KE, Jiang Y, Burns MC, Zhao H, Ho T, Sweitzer S, Schwartz B, Annan RS, Copeland RA, Tummino PJ, Luo L. Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites. The Biochemical Journal. 436: 363-9. PMID 21410436 DOI: 10.1042/BJ20101201  0.84
2011 Van Aller GS, Carson JD, Tang W, Peng H, Zhao L, Copeland RA, Tummino PJ, Luo L. Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor. Biochemical and Biophysical Research Communications. 406: 194-9. PMID 21300025 DOI: 10.1016/j.bbrc.2011.02.010  0.84
2010 Knight SD, Adams ND, Burgess JL, Chaudhari AM, Darcy MG, Donatelli CA, Luengo JI, Newlander KA, Parrish CA, Ridgers LH, Sarpong MA, Schmidt SJ, Van Aller GS, Carson JD, Diamond MA, ... ... Luo L, et al. Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. Acs Medicinal Chemistry Letters. 1: 39-43. PMID 24900173 DOI: 10.1021/ml900028r  0.84
2010 Qian X, McDonald A, Zhou HJ, Adams ND, Parrish CA, Duffy KJ, Fitch DM, Tedesco R, Ashcraft LW, Yao B, Jiang H, Huang JK, Marin MV, Aroyan CE, Wang J, ... ... Luo L, et al. Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295. Acs Medicinal Chemistry Letters. 1: 30-4. PMID 24900171 DOI: 10.1021/ml900018m  0.84
2010 Wood KW, Lad L, Luo L, Qian X, Knight SD, Nevins N, Brejc K, Sutton D, Gilmartin AG, Chua PR, Desai R, Schauer SP, McNulty DE, Annan RS, Belmont LD, et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proceedings of the National Academy of Sciences of the United States of America. 107: 5839-44. PMID 20167803 DOI: 10.1073/pnas.0915068107  0.84
2008 Van Aller GS, Carson JD, Fernandes C, Lehr R, Sinnamon RH, Kirkpatrick RB, Tummino PJ, Luo L. Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay. Analytical Biochemistry. 383: 311-5. PMID 18814837 DOI: 10.1016/j.ab.2008.08.037  0.84
2008 Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA. Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator. Journal of the American Chemical Society. 130: 7584-91. PMID 18491908 DOI: 10.1021/ja710889h  0.84
2008 Lad L, Luo L, Carson JD, Wood KW, Hartman JJ, Copeland RA, Sakowicz R. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 47: 3576-85. PMID 18290633 DOI: 10.1021/bi702061g  0.84
2008 Carson JD, Van Aller G, Lehr R, Sinnamon RH, Kirkpatrick RB, Auger KR, Dhanak D, Copeland RA, Gontarek RR, Tummino PJ, Luo L. Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase. The Biochemical Journal. 409: 519-24. PMID 17877460 DOI: 10.1042/BJ20070681  0.84
2007 Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, et al. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nature Chemical Biology. 3: 722-6. PMID 17922005 DOI: 10.1038/nchembio.2007.34  0.84
2007 Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, ... ... Luo L, et al. Novel ATP-competitive kinesin spindle protein inhibitors. Journal of Medicinal Chemistry. 50: 4939-52. PMID 17725339 DOI: 10.1021/jm070435y  0.84
2006 King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, ... ... Luo L, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Research. 66: 11100-5. PMID 17145850 DOI: 10.1158/0008-5472.CAN-06-2554  0.84
2006 Luo L, Pappalardi MB, Tummino PJ, Copeland RA, Fraser ME, Grzyska PK, Hausinger RP. An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation. Analytical Biochemistry. 353: 69-74. PMID 16643838 DOI: 10.1016/j.ab.2006.03.033  0.84
2004 Luo L, Carson JD, Dhanak D, Jackson JR, Huang PS, Lee Y, Sakowicz R, Copeland RA. Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition. Biochemistry. 43: 15258-66. PMID 15568818 DOI: 10.1021/bi048282t  0.84
2003 Dong J, Lu X, Wei Y, Luo L, Dunaway-Mariano D, Carey PR. The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation. Biochemistry. 42: 9482-90. PMID 12899635 DOI: 10.1021/bi0347656  0.84
2002 Dong J, Carey PR, Wei Y, Luo L, Lu X, Liu RQ, Dunaway-Mariano D. Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme A catalyzed by 4-chlorobenzoyl-coenzyme A dehalogenase. Biochemistry. 41: 7453-63. PMID 12044179 DOI: 10.1021/bi020186+  0.84
2002 Lewandowicz A, Rudzinski J, Luo L, Dunaway-Mariano D, Paneth P. Determination of the chlorine kinetic isotope effect on the 4-chlorobenzoyl-CoA dehalogenase-catalyzed nucleophilic aromatic substitution. Archives of Biochemistry and Biophysics. 398: 249-52. PMID 11831856 DOI: 10.1006/abbi.2001.2722  0.84
2001 Luo L, Taylor KL, Xiang H, Wei Y, Zhang W, Dunaway-Mariano D. Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis. Biochemistry. 40: 15684-92. PMID 11747444 DOI: 10.1021/bi011536f  0.84
2001 Zhang W, Wei Y, Luo L, Taylor KL, Yang G, Dunaway-Mariano D, Benning MM, Holden HM. Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis. Biochemistry. 40: 13474-82. PMID 11695894 DOI: 10.1021/bi0114426  0.84
1999 Xiang H, Luo L, Taylor KL, Dunaway-Mariano D. Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template. Biochemistry. 38: 7638-52. PMID 10387003 DOI: 10.1021/bi9901432  0.84
1999 Dong J, Xiang H, Luo L, Dunaway-Mariano D, Carey PR. Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group. Biochemistry. 38: 4198-206. PMID 10194336 DOI: 10.1021/bi982668k  0.84
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