| Year |
Citation |
Score |
| 2019 |
Paudel P, Zhang Q, Leung C, Greenberg HC, Guo Y, Chern YH, Dong A, Li Y, Vedadi M, Zhuang Z, Tong Y. Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. Proceedings of the National Academy of Sciences of the United States of America. PMID 30914461 DOI: 10.1073/Pnas.1815027116 |
0.414 |
|
| 2018 |
Gong P, Davidson GA, Gui W, Yang K, Bozza WP, Zhuang Z. Activity-based ubiquitin-protein probes reveal target protein specificity of deubiquitinating enzymes. Chemical Science. 9: 7859-7865. PMID 30429995 DOI: 10.1039/C8Sc01573B |
0.405 |
|
| 2018 |
Gui W, Ott CA, Yang K, Chung JS, Shen S, Zhuang Z. Cell-Permeable Activity-Based Ubiquitin Probes Enable Intracellular Profiling of Human Deubiquitinases. Journal of the American Chemical Society. PMID 30240200 DOI: 10.1021/Jacs.8B05147 |
0.326 |
|
| 2017 |
Li G, Yuan L, Zhuang Z. Chemical Synthesis of Activity-Based Diubiquitin Probes. Methods in Molecular Biology (Clifton, N.J.). 1513: 223-232. PMID 27807841 DOI: 10.1007/978-1-4939-6539-7_16 |
0.342 |
|
| 2016 |
Tencer AH, Liang Q, Zhuang Z. Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes. Biochemistry. PMID 27501351 DOI: 10.1021/Acs.Biochem.6B00033 |
0.386 |
|
| 2016 |
Yang K, Li G, Gong P, Gui W, Yuan L, Zhuang Z. Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues. Chembiochem : a European Journal of Chemical Biology. PMID 27113245 DOI: 10.1002/Cbic.201600042 |
0.383 |
|
| 2015 |
Tsutakawa SE, Yan C, Xu X, Zhuang Z, Todd Washington M, Tainer JA, Ivanov I. 112 Structurally distinct ubiquitin- and SUMO-modified PCNA: implications for their distinct roles in the DNA damage response. Journal of Biomolecular Structure & Dynamics. 33: 70-1. PMID 26103323 DOI: 10.1080/07391102.2015.1032745 |
0.369 |
|
| 2015 |
Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I. Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response. Structure (London, England : 1993). 23: 724-33. PMID 25773143 DOI: 10.1016/J.Str.2015.02.008 |
0.37 |
|
| 2014 |
Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A, Zhuang Z, Maloney DJ. Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. Journal of Medicinal Chemistry. 57: 8099-110. PMID 25229643 DOI: 10.1021/Jm5010495 |
0.324 |
|
| 2014 |
Yang K, Gong P, Gokhale P, Zhuang Z. Chemical protein polyubiquitination reveals the role of a noncanonical polyubiquitin chain in DNA damage tolerance. Acs Chemical Biology. 9: 1685-91. PMID 24918305 DOI: 10.1021/Cb500133K |
0.339 |
|
| 2014 |
Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, ... ... Zhuang Z, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nature Chemical Biology. 10: 298-304. PMID 24531842 DOI: 10.1038/Nchembio.1455 |
0.323 |
|
| 2014 |
Li G, Liang Q, Gong P, Tencer AH, Zhuang Z. Activity-based diubiquitin probes for elucidating the linkage specificity of deubiquitinating enzymes. Chemical Communications (Cambridge, England). 50: 216-8. PMID 24225431 DOI: 10.1039/C3Cc47382A |
0.418 |
|
| 2014 |
Dexheimer TS, Rosenthal AS, Luci D, Liang Q, Villamil MA, Jadhav A, Simeonov A, Zhuang Z, Maloney DJ. Abstract LB-11: Discovery, synthesis, and structure-activity relationship of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against non-small cell lung cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-11 |
0.339 |
|
| 2014 |
Tsutakawa S, Yan C, Xu X, Freudenthal B, Weinacht C, Zhuang Z, Washington T, Ivanov I. Structurally Distinct Complexes of Ubiquitin and Sumo-Modified PCNA Lead to Distinct DNA Damage Response Pathways Biophysical Journal. 106: 691a. DOI: 10.1016/J.Bpj.2013.11.3823 |
0.334 |
|
| 2013 |
Villamil MA, Liang Q, Zhuang Z. The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention. Cell Biochemistry and Biophysics. 67: 111-26. PMID 23797609 DOI: 10.1007/S12013-013-9637-1 |
0.383 |
|
| 2013 |
Burkhart RA, Peng Y, Norris ZA, Tholey RM, Talbott VA, Liang Q, Ai Y, Miller K, Lal S, Cozzitorto JA, Witkiewicz AK, Yeo CJ, Gehrmann M, Napper A, Winter JM, ... ... Zhuang Z, et al. Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival Molecular Cancer Research. 11: 901-911. PMID 23696131 DOI: 10.1158/1541-7786.Mcr-12-0699 |
0.337 |
|
| 2013 |
Yang K, Weinacht CP, Zhuang Z. Regulatory role of ubiquitin in eukaryotic DNA translesion synthesis. Biochemistry. 52: 3217-28. PMID 23634825 DOI: 10.1021/Bi400194R |
0.319 |
|
| 2012 |
Bozza WP, Liang Q, Gong P, Zhuang Z. Transient kinetic analysis of USP2-catalyzed deubiquitination reveals a conformational rearrangement in the K48-linked diubiquitin substrate. Biochemistry. 51: 10075-86. PMID 23211065 DOI: 10.1021/Bi3009104 |
0.444 |
|
| 2012 |
Villamil MA, Liang Q, Chen J, Choi YS, Hou S, Lee KH, Zhuang Z. Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. Biochemistry. 51: 9112-23. PMID 23116119 DOI: 10.1021/Bi300845S |
0.369 |
|
| 2012 |
Juhasz S, Balogh D, Hajdu I, Burkovics P, Villamil MA, Zhuang Z, Haracska L. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. Nucleic Acids Research. 40: 10795-808. PMID 22987070 DOI: 10.1093/Nar/Gks850 |
0.321 |
|
| 2012 |
Song F, Thoden JB, Zhuang Z, Latham J, Trujillo M, Holden HM, Dunaway-Mariano D. The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU. Biochemistry. 51: 7000-16. PMID 22873756 DOI: 10.1021/Bi301059M |
0.77 |
|
| 2012 |
Villamil MA, Chen J, Liang Q, Zhuang Z. A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated factor 1. Biochemistry. 51: 2829-39. PMID 22439892 DOI: 10.1021/Bi3000512 |
0.451 |
|
| 2012 |
Dong J, Zhuang Z, Song F, Dunaway-Mariano D, Carey PR. A Thioester Substrate Binds to the Enzyme Arthrobacter Thioesterase in Two Ionization States; Evidence from Raman Difference Spectroscopy. Journal of Raman Spectroscopy : Jrs. 43: 65-71. PMID 22347769 DOI: 10.1002/Jrs.3002 |
0.697 |
|
| 2012 |
Zhuang Z, Latham J, Song F, Zhang W, Trujillo M, Dunaway-Mariano D. Investigation of the catalytic mechanism of the hotdog-fold enzyme superfamily Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase. Biochemistry. 51: 786-94. PMID 22208697 DOI: 10.1021/Bi2013917 |
0.743 |
|
| 2011 |
Tsutakawa SE, Van Wynsberghe AW, Freudenthal BD, Weinacht CP, Gakhar L, Washington MT, Zhuang Z, Tainer JA, Ivanov I. Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA. Proceedings of the National Academy of Sciences of the United States of America. 108: 17672-7. PMID 22006297 DOI: 10.1073/Pnas.1110480108 |
0.375 |
|
| 2011 |
Bozza WP, Zhuang Z. Biochemical characterization of a multidomain deubiquitinating enzyme Ubp15 and the regulatory role of its terminal domains. Biochemistry. 50: 6423-32. PMID 21710968 DOI: 10.1021/Bi200529Z |
0.458 |
|
| 2011 |
Ai Y, Wang J, Johnson RE, Haracska L, Prakash L, Zhuang Z. A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase η. Molecular Biosystems. 7: 1874-82. PMID 21483899 DOI: 10.1039/C0Mb00355G |
0.357 |
|
| 2011 |
Chen J, Bozza W, Zhuang Z. Ubiquitination of PCNA and its essential role in eukaryotic translesion synthesis. Cell Biochemistry and Biophysics. 60: 47-60. PMID 21461937 DOI: 10.1007/S12013-011-9187-3 |
0.32 |
|
| 2010 |
Chen J, Ai Y, Wang J, Haracska L, Zhuang Z. Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis. Nature Chemical Biology. 6: 270-2. PMID 20208521 DOI: 10.1038/Nchembio.316 |
0.337 |
|
| 2009 |
Li Z, Song F, Zhuang Z, Dunaway-Mariano D, Anderson KS. Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry. Analytical Biochemistry. 394: 209-16. PMID 19635449 DOI: 10.1016/J.Ab.2009.07.030 |
0.683 |
|
| 2008 |
Zhuang Z, Johnson RE, Haracska L, Prakash L, Prakash S, Benkovic SJ. Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 5361-6. PMID 18385374 DOI: 10.1073/Pnas.0801310105 |
0.309 |
|
| 2008 |
Willis MA, Zhuang Z, Song F, Howard A, Dunaway-Mariano D, Herzberg O. Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase. Biochemistry. 47: 2797-805. PMID 18260643 DOI: 10.1021/Bi702336D |
0.724 |
|
| 2008 |
Zhuang Z, Song F, Zhao H, Li L, Cao J, Eisenstein E, Herzberg O, Dunaway-Mariano D. Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA. Biochemistry. 47: 2789-96. PMID 18247525 DOI: 10.1021/Bi702334H |
0.713 |
|
| 2007 |
Song F, Zhuang Z, Dunaway-Mariano D. Structure-activity analysis of base and enzyme-catalyzed 4-hydroxybenzoyl coenzyme A hydrolysis. Bioorganic Chemistry. 35: 1-10. PMID 16962159 DOI: 10.1016/J.Bioorg.2006.07.002 |
0.704 |
|
| 2006 |
Smiley RD, Zhuang Z, Benkovic SJ, Hammes GG. Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation. Biochemistry. 45: 7990-7. PMID 16800624 DOI: 10.1021/Bi0603322 |
0.33 |
|
| 2006 |
Zhuang Z, Berdis AJ, Benkovic SJ. An alternative clamp loading pathway via the T4 clamp loader gp44/62-DNA complex. Biochemistry. 45: 7976-89. PMID 16800623 DOI: 10.1021/Bi0601205 |
0.321 |
|
| 2006 |
Zhuang Z, Yoder BL, Burgers PM, Benkovic SJ. The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer. Proceedings of the National Academy of Sciences of the United States of America. 103: 2546-51. PMID 16476998 DOI: 10.1073/Pnas.0511263103 |
0.346 |
|
| 2006 |
Song F, Zhuang Z, Finci L, Dunaway-Mariano D, Kniewel R, Buglino JA, Solorzano V, Wu J, Lima CD. Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI. The Journal of Biological Chemistry. 281: 11028-38. PMID 16464851 DOI: 10.1074/Jbc.M513896200 |
0.715 |
|
| 2005 |
Xi J, Zhang Z, Zhuang Z, Yang J, Spiering MM, Hammes GG, Benkovic SJ. Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome. Biochemistry. 44: 7747-56. PMID 15909989 DOI: 10.1021/Bi047296W |
0.304 |
|
| 2005 |
Yang J, Xi J, Zhuang Z, Benkovic SJ. The oligomeric T4 primase is the functional form during replication. The Journal of Biological Chemistry. 280: 25416-23. PMID 15897200 DOI: 10.1074/Jbc.M501847200 |
0.38 |
|
| 2005 |
Willis MA, Song F, Zhuang Z, Krajewski W, Chalamasetty VR, Reddy P, Howard A, Dunaway-Mariano D, Herzberg O. Structure of YciI from Haemophilus influenzae (HI0828) reveals a ferredoxin-like alpha/beta-fold with a histidine/aspartate centered catalytic site. Proteins. 59: 648-52. PMID 15779043 DOI: 10.1002/Prot.20411 |
0.63 |
|
| 2005 |
Xi J, Zhuang Z, Zhang Z, Selzer T, Spiering MM, Hammes GG, Benkovic SJ. Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly. Biochemistry. 44: 2305-18. PMID 15709743 DOI: 10.1021/Bi0479508 |
0.302 |
|
| 2004 |
Yang J, Zhuang Z, Roccasecca RM, Trakselis MA, Benkovic SJ. The dynamic processivity of the T4 DNA polymerase during replication. Proceedings of the National Academy of Sciences of the United States of America. 101: 8289-94. PMID 15148377 DOI: 10.1073/Pnas.0402625101 |
0.317 |
|
| 2004 |
Zhuang Z, Song F, Takami H, Dunaway-Mariano D. The BH1999 protein of Bacillus halodurans C-125 is gentisyl-coenzyme A thioesterase. Journal of Bacteriology. 186: 393-9. PMID 14702308 DOI: 10.1128/Jb.186.2.393-399.2004 |
0.7 |
|
| 2003 |
Thoden JB, Zhuang Z, Dunaway-Mariano D, Holden HM. The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU. The Journal of Biological Chemistry. 278: 43709-16. PMID 12907670 DOI: 10.1074/Jbc.M308198200 |
0.647 |
|
| 2003 |
Zhuang Z, Gartemann KH, Eichenlaub R, Dunaway-Mariano D. Characterization of the 4-hydroxybenzoyl-coenzyme A thioesterase from Arthrobacter sp. strain SU. Applied and Environmental Microbiology. 69: 2707-11. PMID 12732540 DOI: 10.1128/Aem.69.5.2707-2711.2003 |
0.598 |
|
| 2002 |
Zhuang Z, Song F, Zhang W, Taylor K, Archambault A, Dunaway-Mariano D, Dong J, Carey PR. Kinetic, Raman, NMR, and site-directed mutagenesis studies of the Pseudomonas sp. strain CBS3 4-hydroxybenzoyl-CoA thioesterase active site. Biochemistry. 41: 11152-60. PMID 12220180 DOI: 10.1021/Bi0262303 |
0.714 |
|
| 2002 |
Thoden JB, Holden HM, Zhuang Z, Dunaway-Mariano D. X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase. The Journal of Biological Chemistry. 277: 27468-76. PMID 11997398 DOI: 10.1074/Jbc.M203904200 |
0.674 |
|
| 2002 |
Zhuang Z, Song F, Martin BM, Dunaway-Mariano D. The YbgC protein encoded by the ybgC gene of the tol-pal gene cluster of Haemophilus influenzae catalyzes acyl-coenzyme A thioester hydrolysis. Febs Letters. 516: 161-3. PMID 11959124 DOI: 10.1016/S0014-5793(02)02533-4 |
0.653 |
|
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