Patrick J. Loll - Publications

Affiliations: 
2001 Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
 2001- Biochemistry & Molecular Biology Drexel University College of Medicine, Philadelphia, PA, United States 
Area:
Protein crystallography, antibiotic resistance
Website:
http://drexel.edu/medicine/faculty/profiles/Patrick-Loll/

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Maciunas LJ, Porter N, Lee PJ, Gupta K, Loll PJ. Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states. Acta Crystallographica. Section D, Structural Biology. 77: 1027-1039. PMID 34342276 DOI: 10.1107/S2059798321006288  1
2021 Lénon M, Ke N, Ren G, Meuser ME, Loll PJ, Riggs P, Berkmen M. A useful epitope tag derived from maltose binding protein. Protein Science : a Publication of the Protein Society. PMID 33896065 DOI: 10.1002/pro.4088  0.01
2019 Grasty KC, Weeks SD, Loll PJ. Structural insights into the activity and regulation of human Josephin-2. Journal of Structural Biology: X. 3: 100011. PMID 32647816 DOI: 10.1016/J.Yjsbx.2019.100011  1
2019 Tronin AY, Maciunas LJ, Grasty KC, Loll PJ, Ambaye HA, Parizzi AA, Lauter V, Geragotelis AD, Freites JA, Tobias DJ, Blasie JK. Voltage-Dependent Profile Structures of a Kv-Channel via Time-Resolved Neutron Interferometry. Biophysical Journal. PMID 31378315 DOI: 10.1016/J.Bpj.2019.07.011  1
2019 Jackson MR, Loll PJ, Jorns MS. X-Ray Structure of Human Sulfide:Quinone Oxidoreductase: Insights into the Mechanism of Mitochondrial Hydrogen Sulfide Oxidation. Structure (London, England : 1993). PMID 30905673 DOI: 10.1016/J.Str.2019.03.002  0.01
2019 Upton EC, Maciunas LJ, Loll PJ. Vancomycin does not affect the enzymatic activities of purified VanSA. Plos One. 14: e0210627. PMID 30677074 DOI: 10.1371/Journal.Pone.0210627  1
2018 Loll PJ. Structural Analysis of Anesthetics in Complex with Soluble Proteins. Methods in Enzymology. 603: 3-20. PMID 29673532 DOI: 10.1016/Bs.Mie.2018.01.016  0.01
2017 Rao MV, Williams DR, Cocklin S, Loll PJ. Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding. The Journal of Biological Chemistry. PMID 28939772 DOI: 10.1074/Jbc.M117.806281  1
2017 Bonneté F, Loll PJ. Characterization of New Detergents and Detergent Mimetics by Scattering Techniques for Membrane Protein Crystallization. Methods in Molecular Biology (Clifton, N.J.). 1635: 169-193. PMID 28755369 DOI: 10.1007/978-1-4939-7151-0_9  0.01
2017 Woll KA, Peng W, Liang Q, Zhi L, Jacobs JA, Maciunas L, Bhanu N, Garcia BA, Covarrubias M, Loll PJ, Dailey WP, Eckenhoff RG. Photoaffinity ligand for the inhalational anesthetic sevoflurane allows mechanistic insight into potassium channel modulation. Acs Chemical Biology. PMID 28333442 DOI: 10.1021/Acschembio.7B00222  1
2017 Bu W, Liang Q, Zhi L, Maciunas L, Loll PJ, Eckenhoff RG, Covarrubias M. Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels. Molecular Neurobiology. PMID 28204960 DOI: 10.1007/S12035-017-0437-2  1
2016 Kinde MN, Bondarenko V, Granata D, Bu W, Grasty KC, Loll PJ, Carnevale V, Klein ML, Eckenhoff RG, Tang P, Xu Y. Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac. Proceedings of the National Academy of Sciences of the United States of America. PMID 27856739 DOI: 10.1073/Pnas.1609939113  1
2016 Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884182 DOI: 10.1073/Pnas.1516967113  1
2014 Loll PJ. Membrane proteins, detergents and crystals: what is the state of the art? Acta Crystallographica. Section F, Structural Biology Communications. 70: 1576-83. PMID 25484203 DOI: 10.1107/S2053230X14025035  1
2014 Loll PJ, Xu P, Schmidt JT, Melideo SL. Enhancing ubiquitin crystallization through surface-entropy reduction. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1434-42. PMID 25286958 DOI: 10.1107/S2053230X14019244  1
2014 Loll PJ, Upton EC, Nahoum V, Economou NJ, Cocklin S. The high resolution structure of tyrocidine A reveals an amphipathic dimer. Biochimica Et Biophysica Acta. 1838: 1199-207. PMID 24530898 DOI: 10.1016/J.Bbamem.2014.01.033  1
2014 Sha X, Xu X, Sohlberg K, Loll PJ, Penn LS. Evidence that three-regime kinetics is inherent to formation of a polymer brush by a grafting-to approach Rsc Advances. 4: 42122-42128. DOI: 10.1039/C4Ra05663A  1
2013 Economou NJ, Cocklin S, Loll PJ. High-resolution crystal structure reveals molecular details of target recognition by bacitracin. Proceedings of the National Academy of Sciences of the United States of America. 110: 14207-12. PMID 23940351 DOI: 10.1073/Pnas.1308268110  1
2013 Economou NJ, Zentner IJ, Lazo E, Jakoncic J, Stojanoff V, Weeks SD, Grasty KC, Cocklin S, Loll PJ. Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach. Acta Crystallographica. Section D, Biological Crystallography. 69: 520-33. PMID 23519660 DOI: 10.1107/S0907444912050469  1
2012 Sha X, Sun C, Xu X, Alexander L, Loll PJ, Penn LS. Quartz crystal microbalance (QCM): useful for developing procedures for immobilization of proteins on solid surfaces. Analytical Chemistry. 84: 10298-305. PMID 23121645 DOI: 10.1021/Ac302275R  1
2012 Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF. Structural basis for calmodulin as a dynamic calcium sensor. Structure (London, England : 1993). 20: 911-23. PMID 22579256 DOI: 10.1016/J.Str.2012.03.019  1
2012 Liu R, Bu W, Xi J, Mortazavi SR, Cheung-Lau JC, Dmochowski IJ, Loll PJ. Beyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritin. Acta Crystallographica. Section D, Biological Crystallography. 68: 497-504. PMID 22525747 DOI: 10.1107/S0907444912002740  1
2012 Bu W, Liu R, Cheung-Lau JC, Dmochowski IJ, Loll PJ, Eckenhoff RG. Ferritin couples iron and fatty acid metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2394-400. PMID 22362897 DOI: 10.1096/Fj.11-198853  1
2012 Oakley S, Vedula LS, Bu W, Meng QC, Xi J, Liu R, Eckenhoff RG, Loll PJ. Recognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis. Plos One. 7: e32070. PMID 22359658 DOI: 10.1371/Journal.Pone.0032070  1
2012 Economou NJ, Nahoum V, Weeks SD, Grasty KC, Zentner IJ, Townsend TM, Bhuiya MW, Cocklin S, Loll PJ. A carrier protein strategy yields the structure of dalbavancin. Journal of the American Chemical Society. 134: 4637-45. PMID 22352468 DOI: 10.1021/Ja208755J  1
2011 Ishino T, Economou NJ, McFadden K, Zaks-Zilberman M, Jost M, Baxter S, Contarino MR, Harrington AE, Loll PJ, Pasut G, Lievens S, Tavernier J, Chaiken I. A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α. Biochemistry. 50: 7546-56. PMID 21770429 DOI: 10.1021/Bi2009135  1
2011 Weeks SD, Grasty KC, Hernandez-Cuebas L, Loll PJ. Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. The Journal of Biological Chemistry. 286: 4555-65. PMID 21118805 DOI: 10.1074/Jbc.M110.177360  1
2011 Robinson AS, Loll PJ. Introduction Production of Membrane Proteins: Strategies For Expression and Isolation. 1-9. DOI: 10.1002/9783527634521.ch  1
2009 Weeks SD, Grasty KC, Hernandez-Cuebas L, Loll PJ. Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture. Proteins. 77: 753-9. PMID 19731378 DOI: 10.1002/Prot.22568  1
2009 Hamburger JB, Hoertz AJ, Lee A, Senturia RJ, McCafferty DG, Loll PJ. A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. Proceedings of the National Academy of Sciences of the United States of America. 106: 13759-64. PMID 19666597 DOI: 10.1073/Pnas.0904686106  1
2009 Nahoum V, Spector S, Loll PJ. Structure of ristocetin A in complex with a bacterial cell-wall mimetic. Acta Crystallographica. Section D, Biological Crystallography. 65: 832-8. PMID 19622867 DOI: 10.1107/S0907444909018344  1
2009 Vedula LS, Brannigan G, Economou NJ, Xi J, Hall MA, Liu R, Rossi MJ, Dailey WP, Grasty KC, Klein ML, Eckenhoff RG, Loll PJ. A unitary anesthetic binding site at high resolution. The Journal of Biological Chemistry. 284: 24176-84. PMID 19605349 DOI: 10.1074/Jbc.M109.017814  1
2009 Loll PJ, Derhovanessian A, Shapovalov MV, Kaplan J, Yang L, Axelsen PH. Vancomycin forms ligand-mediated supramolecular complexes. Journal of Molecular Biology. 385: 200-11. PMID 18983853 DOI: 10.1016/J.Jmb.2008.10.049  1
2008 Loll PJ, Swain E, Chen Y, Turner BT, Zhang JF. Structure of the SH3 domain of rat endophilin A2. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 243-6. PMID 18391417 DOI: 10.1107/S1744309108007574  1
2007 Weeks SD, Drinker M, Loll PJ. Ligation independent cloning vectors for expression of SUMO fusions. Protein Expression and Purification. 53: 40-50. PMID 17251035 DOI: 10.1016/J.Pep.2006.12.006  1
2006 Xi J, Liu R, Rossi MJ, Yang J, Loll PJ, Dailey WP, Eckenhoff RG. Photoactive analogues of the haloether anesthetics provide high-resolution features from low-affinity interactions. Acs Chemical Biology. 1: 377-84. PMID 17163775 DOI: 10.1021/Cb600207D  1
2006 Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM. Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. Journal of Molecular Recognition : Jmr. 19: 354-62. PMID 16775845 DOI: 10.1002/Jmr.784  1
2006 Gupta K, Selinsky BS, Loll PJ. 2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor. Acta Crystallographica. Section D, Biological Crystallography. 62: 151-6. PMID 16421446 DOI: 10.1107/S0907444905036309  1
2005 Liu R, Loll PJ, Eckenhoff RG. Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 567-76. PMID 15791007 DOI: 10.1096/Fj.04-3171Com  1
2005 Eckenhoff RG, Liu R, Johansson JS, Loll PJ. The four-helix bundle: An attractive fold International Congress Series. 1283: 15-20. DOI: 10.1016/j.ics.2005.06.079  1
2004 Zakharov SD, Eroukova VY, Rokitskaya TI, Zhalnina MV, Sharma O, Loll PJ, Zgurskaya HI, Antonenko YN, Cramer WA. Colicin occlusion of OmpF and TolC channels: outer membrane translocons for colicin import. Biophysical Journal. 87: 3901-11. PMID 15465872 DOI: 10.1529/Biophysj.104.046151  1
2004 Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ. Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 667-71. PMID 14741265 DOI: 10.1016/J.Bmcl.2003.11.034  1
2004 Gupta K, Selinsky BS, Kaub CJ, Katz AK, Loll PJ. The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase. Journal of Molecular Biology. 335: 503-18. PMID 14672659 DOI: 10.1016/J.Jmb.2003.10.073  1
2003 Loll PJ, Tretiakova A, Soderblom E. Compatibility of detergents with the microbatch-under-oil crystallization method. Acta Crystallographica. Section D, Biological Crystallography. 59: 1114-6. PMID 12777792 DOI: 10.1107/S0907444903008175  1
2003 Loll PJ. Membrane protein structural biology: the high throughput challenge. Journal of Structural Biology. 142: 144-53. PMID 12718926 DOI: 10.1016/S1047-8477(03)00045-5  1
2003 Jusuf S, Loll PJ, Axelsen PH. Configurational entropy and cooperativity between ligand binding and dimerization in glycopeptide antibiotics. Journal of the American Chemical Society. 125: 3988-94. PMID 12656635 DOI: 10.1021/Ja027780R  1
2002 Jusuf S, Loll PJ, Axelsen PH. The role of configurational entropy in biochemical cooperativity. Journal of the American Chemical Society. 124: 3490-1. PMID 11929222 DOI: 10.1021/Ja017259H  1
2002 Loll PJ, Hitscherich C, Aseyev V, Allaman M, Wiencek J. Assessing Micellar Interaction and Growth in Detergent Solutions Used to Crystallize Integral Membrane Proteins Crystal Growth and Design. 2: 533-539. DOI: 10.1021/Cg025563W  1
2001 Loll PJ, Sharkey CT, O'Connor SJ, Dooley CM, O'Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions. Molecular Pharmacology. 60: 1407-13. PMID 11723249  1
2001 Bevivino AE, Loll PJ. An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils. Proceedings of the National Academy of Sciences of the United States of America. 98: 11955-60. PMID 11572942 DOI: 10.1073/Pnas.211305198  1
2001 Mattoon D, Gupta K, Doyon J, Loll PJ, DiMaio D. Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene. 20: 3824-34. PMID 11439346 DOI: 10.1038/Sj.Onc.1204523  1
2001 Hitscherich C. J, Aseyev V, Wiencek J, Loll PJ. Effects of PEG on detergent micelles: Implications for the crystallization of integral membrane proteins Acta Crystallographica Section D: Biological Crystallography. 57: 1020-1029. PMID 11418772 DOI: 10.1107/S0907444901006242  1
2001 Loll PJ. De novo structure determination of vancomycin aglycon using the anomalous scattering of chlorine Acta Crystallographica Section D: Biological Crystallography. 57: 977-980. PMID 11418765 DOI: 10.1107/S0907444901007314  1
2001 FitzGerald GA, Loll P. COX in a crystal ball: current status and future promise of prostaglandin research. The Journal of Clinical Investigation. 107: 1335-7. PMID 11390412 DOI: 10.1172/Jci13037  0.01
2001 Kaplan J, Korty BD, Axelsen PH, Loll PJ. The role of sugar residues in molecular recognition by vancomycin Journal of Medicinal Chemistry. 44: 1837-1840. PMID 11356118 DOI: 10.1021/Jm0005306  1
2001 Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 40: 5172-80. PMID 11318639 DOI: 10.1021/Bi010045S  1
2001 Loll PJ, Allaman M, Wiencek J. Assessing the role of detergent-detergent interactions in membrane protein crystallization Journal of Crystal Growth. 232: 432-438. DOI: 10.1016/S0022-0248(01)01076-4  1
2000 Hitscherich C, Kaplan J, Allaman M, Wiencek J, Loll PJ. Static light scattering studies of OmpF porin: Implications for integral membrane protein crystallization Protein Science. 9: 1559-1566. PMID 10975577 DOI: 10.1110/Ps.9.8.1559  1
2000 Loll PJ, Axelsen PH. The structural biology of molecular recognition by vancomycin Annual Review of Biophysics and Biomolecular Structure. 29: 265-289. PMID 10940250 DOI: 10.1146/Annurev.Biophys.29.1.265  1
1999 Loll PJ, Kaplan J, Selinsky BS, Axelsen PH. Vancomycin binding to low-affinity ligands: Delineating a minimum set of interactions necessary for high-affinity binding Journal of Medicinal Chemistry. 42: 4714-4719. PMID 10579833 DOI: 10.1021/Jm990361T  1
1998 Loll PJ, Miller R, Weeks CM, Axelsen PH. A ligand-mediated dimerization mode for vancomycin Chemistry and Biology. 5: 293-298.  1
1997 Picot D, Loll PJ, Garavito RM. X-ray crystallographic study of the structure of prostaglandin H synthase. Advances in Experimental Medicine and Biology. 400: 107-11. PMID 9547544  1
1997 Funk CD, Loll PJ. A molecular dipstick? Nature Structural Biology. 4: 966-968. PMID 9406540  1
1997 Loll PJ, Bevivino AE, Korty BD, Axelsen PH. Simultaneous recognition of a carboxylate-containing ligand and an intramolecular surrogate ligand in the crystal structure of an asymmetric vancomycin dimer Journal of the American Chemical Society. 119: 1516-1522. DOI: 10.1021/Ja963566P  1
1996 Loll PJ, Garavito RM, Carrell CJ, Carrell HL. 1-(4-iodobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid, an iodinated indomethacin analog. Acta Crystallographica. Section C, Crystal Structure Communications. 52: 455-7. PMID 8829363  1
1996 Loll PJ, Garavito RM, Carrell CJ, Carrell HL. 2-bromoacetoxybenzoic acid, a brominated aspirin analog. Acta Crystallographica. Section C, Crystal Structure Communications. 52: 375-7. PMID 8829360  1
1996 Garavito RM, Picot D, Loll PJ. Strategies for crystallizing membrane proteins. Journal of Bioenergetics and Biomembranes. 28: 13-27. PMID 8786233  1
1996 Loll PJ, Picot D, Ekabo O, Garavito RM. Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site. Biochemistry. 35: 7330-40. PMID 8652509 DOI: 10.1021/bi952776w  1
1996 Loll PJ, Garavito RM, Carrell CJ, Carrell HL. 2-bromoacetoxybenzoic acid, a brominated aspirin analog Acta Crystallographica Section C: Crystal Structure Communications. 52: 375-377.  1
1995 Garavito RM, Picot D, Loll PJ. Preliminary X-Ray Investigations Into NSAID-Binding to Cyclooxygenase-1. American Journal of Therapeutics. 2: 611-615. PMID 11854835  1
1995 Harlan JE, Picot D, Loll PJ, Garavito RM. Calibration of size-exclusion chromatography: use of a double Gaussian distribution function to describe pore sizes. Analytical Biochemistry. 224: 557-63. PMID 7733458 DOI: 10.1006/abio.1995.1087  1
1995 Garavito RM, Picot D, Loll PJ. The 3.1 A X-ray crystal structure of the integral membrane enzyme prostaglandin H2 synthase-1. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. 23: 99-103. PMID 7732912  1
1995 Loll PJ, Quirk S, Lattman EE, Garavito RM. X-ray crystal structures of staphylococcal nuclease complexed with the competitive inhibitor cobalt(II) and nucleotide. Biochemistry. 34: 4316-24. PMID 7703245  1
1995 Loll PJ, Picot D, Garavito RM. The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Nature Structural Biology. 2: 637-43. PMID 7552725 DOI: 10.1038/nsb0895-637  1
1994 Picot D, Loll PJ, Garavito RM. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367: 243-9. PMID 8121489 DOI: 10.1038/367243a0  1
1994 Garavito RM, Picot D, Loll PJ. Prostaglandin H synthase Current Opinion in Structural Biology. 4: 529-535. DOI: 10.1016/S0959-440X(94)90215-1  1
1994 Loll PJ, Garavito RM. The isoforms of cyclooxygenase: Structure and function Expert Opinion On Investigational Drugs. 3: 1171-1180.  1
1990 Loll PJ, Lattman EE. Active site mutant Glu-43 → Asp in staphylococcal nuclease displays nonlocal structureal changes Biochemistry. 29: 6866-6873. PMID 2397218 DOI: 10.1021/bi00481a016  1
1990 Loll PJ, Sparks RA, Lattman EE. Omega-scan artifact observed in Nicolet P3F diffractometers Journal of Applied Crystallography. 23: 212-214.  1
1989 Loll PJ, Lattman EE. The crystal structure of the ternary complex of staphylococcal nuclease, Ca2+, and the inhibitor pdTp, Refined at 1.65 Å Proteins: Structure, Function and Genetics. 5: 183-201. PMID 2780539  1
1988 Loll PJ, Meeker AK, Shortle D, Pease M, Lattman EE. Crystallization and preliminary X-ray analysis of a quadruple mutant of staphylococcal nuclease Journal of Biological Chemistry. 263: 18190-18192. PMID 3192532  1
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